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1. WHO global research priorities for antimicrobial resistance in human health

Author

Aanensen, David, Alanio, Alexandre, Alastruey-Izquierdo, Ana, Alemayehu, Tinsae, Al-Hasan, Majdi, Allegaert, Karel, Al-Maani, Amal Saif, Al-Salman, Jameela, Alshukairi, Abeer Nizar, Amir, Afreenish, Applegate, Tanya, Araj, George F, Villalobos, Marlen Arce, Årdal, Christine, Ashiru-Oredope, Diane, Ashley, Elizabeth A, Babin, François-Xavier, Bachmann, Laura H, Bachmann, Till, Baker, Kate Susan, Balasegaram, Manica, Bamford, Colleen, Baquero, Fernando, Barcelona, Laura Isabel, Bassat, Quique, Bassetti, Matteo, Basu, Sulagna, Beardsley, Justin, Vásquez, Grey Benoit, Berkley, James A, Bhatnagar, Anuj K, Bielicki, Julia, Bines, Julie, Bongomin, Felix, Bonomo, Robert A, Bradley, John S, Bradshaw, Catriona, Brett, Ana, Brink, Adrian, Brown, Colin, Brown, Jeremy, Buising, Kirsty, Carson, Carolee, Carvalho, Anna Cristina, Castagnola, Elio, Cavaleri, Marco, Cecchini, Michele, Chabala, Chishala, Chaisson, Richard E, Chakrabarti, Arunaloke, Chandler, Clare, Chandy, Sujith John, Charani, Esmita, Chen, Lisa, Chiara, Francesca, Chowdhary, Anuradha, Chua, Arlene, Chuki, Pem, Chun, Doo Ryeon, Churchyard, Gavin, Cirillo, Daniela, Clack, Lauren, Coffin, Susan E, Cohn, Jennifer, Cole, Michelle, Conly, John, Cooper, Ben, Corso, Alejandra, Cosgrove, Sara E, Cox, Helen, Daley, Charles L, Darboe, Saffiatou, Darton, Tom, Davies, Gerry, de Egea, Viviana, Dedeić-Ljubović, Amela, Deeves, Miranda, Denkinger, Claudia, Dillon, Jo-Anne R, Dramowski, Angela, Eley, Brian, Roberta Esposito, Susanna Maria, Essack, Sabiha Y, Farida, Helmia, Farooqi, Joveria, Feasey, Nicholas, Ferreyra, Cecilia, Fifer, Helen, Finlayson, Heather, Frick, Mike, Gales, Ana Cristina, Galli, Luisa, Gandra, Sumanth, Gerber, Jeffrey S, Giske, Christian, Gordon, Bruce, Govender, Nelesh, Guessennd, Nathalie, Guindo, Ibrehima, Gurbanova, Elmira, Gwee, Amanda, Hagen, Ferry, Harbarth, Stephan, Haze, John, Heim, Jutta, Hendriksen, Rene, Heyderman, Robert Simon, Holt, Kathryn Elizabeth, Hönigl, Martin, Hook, Edward W, Hope, William, Hopkins, Heidi, Hughes, Gwenda, Ismail, Ghada, Issack, Mohammad Iqbal, Jacobs, Jan, Jasovský, Dušan, Jehan, Fyeza, Pearson, Antonieta Jimenez, Jones, Makoto, Joshi, Mohan P, Kapil, Arti, Kariuki, Samuel, Karkey, Abhilasha, Kearns, Gregory L, Keddy, Karen Helena, Khanna, Nina, Kitamura, Akiko, Kolho, Kaija-Leena, Kontoyiannis, Dimitrios P, Kotwani, Anita, Kozlov, Roman S, Kranzer, Katharina, Kularatne, Ranmini, Lahra, Monica M, Langford, Bradley J, Laniado-Laborin, Rafael, Larsson, D G Joakim, Lass-Flörl, Cornelia, Le Doare, Kirsty, Lee, Hyukmin, Lessa, Fernanda, Levin, Anna S, Limmathurotsakul, Direk, Lincopan, Nilton, Lo Vecchio, Andrea, Lodha, Rakesh, Loeb, Mark, Longtin, Yves, Lye, David Chien, Mahmud, Asif Mujtaba, Manaia, Célia, Manderson, Lenore, Mareković, Ivana, Marimuthu, Kalisvar, Martin, Irene, Mashe, Tapfumanei, Mei, Zeng, Meis, Jacques F, Lyra Tavares De Melo, Flávio Augusto, Mendelson, Marc, Miranda, Angelica Espinosa, Moore, David, Morel, Chantal, Moremi, Nyambura, Moro, Maria Luisa, Moussy, Francis, Mshana, Stephen, Mueller, Arno, Ndow, Francis J, Nicol, Mark, Nunn, Andrew, Obaro, Stephen, Obiero, Christina W, Okeke, Iruka N, Okomo, Uduak, Okwor, Tochi J, Oladele, Rita, Omulo, Sylvia, Ondoa, Pascale, Ortellado de Canese, Juana Medarda, Ostrosky-Zeichner, Luis, Padoveze, Maria Clara, Pai, Madhukar, Park, Benjamin, Parkhill, Julian, Parry, Christopher M, Peeling, Rosanna, Sobreira Vieira Peixe, Luísa Maria, Perovic, Olga, Pettigrew, Melinda M, Principi, Nicola, Pulcini, Céline, Puspandari, Nelly, Rawson, Timothy, Reddy, Denasha Lavanya, Reddy, Kessendri, Redner, Paulo, Rodríguez Tudela, Juan Luis, Rodríguez-Baño, Jesús, Van Katwyk, Susan Rogers, Roilides, Emmanuel, Rollier, Christine, Rollock, Leslie, Ronat, Jean-Baptiste, Ruppe, Etienne, Sadarangani, Manish, Salisbury, David, Salou, Mounerou, Samison, Luc Hervé, Sanguinetti, Maurizio, Sartelli, Massimo, Schellack, Natalie, Schouten, Jeroen, Schwaber, Mitchell J, Seni, Jeremiah, Senok, Abiola, Shafer, William M, Shakoor, Sadia, Sheppard, Donald, Shin, Jong-Hee, Sia, Sonia, Sievert, Dawn, Singh, Ishwar, Singla, Rupak, Skov, Robert Leo, Soge, Olusegun O, Sprute, Rosanne, Srinivasan, Arjun, Srinivasan, Subasree, Sundsfjord, Arnfinn, Tacconelli, Evelina, Tahseen, Sabira, Tangcharoensathien, Viroj, Tängdén, Thomas, Thursky, Karin, Thwaites, Guy, Tigulini de Souza Peral, Renata, Tong, Deborah, Tootla, Hafsah Deepa, Tsioutis, Constantinos, Turner, Katy M, Turner, Paul, Omar, Shaheed Vally, van de Sande, Wendy WJ, van den Hof, Susan, van Doorn, Rogier, Veeraraghavan, Balaji, Verweij, Paul, Wahyuningsih, Retno, Wang, Hui, Warris, Adilia, Weinstock, Hillard, Wesangula, Evelyn, Whiley, David, White, Peter J, Williams, Phoebe, Xiao, Yonghong, Moscoso, Martin Yagui, Yang, Hsu Li, Yoshida, Sachiyo, Yu, Yunsong, Żabicka, Dorota, Zignol, Matteo, Rudan, Igor, Bertagnolio, Silvia, Dobreva, Zlatina, Centner, Chad M, Olaru, Ioana Diana, Donà, Daniele, Burzo, Stefano, Huttner, Benedikt D, Chaillon, Antoine, Gebreselassie, Nebiat, Wi, Teodora, Hasso-Agopsowicz, Mateusz, Allegranzi, Benedetta, Sati, Hatim, Ivanovska, Verica, Kothari, Kavita U, Balkhy, Hanan H, Cassini, Alessandro, Hamers, Raph L, and Weezenbeek, Kitty Van

Published
2024
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2. The burden of bacterial antimicrobial resistance in the WHO African region in 2019: a cross-country systematic analysis

Author

Sartorius, Benn, Gray, Authia P, Davis Weaver, Nicole, Robles Aguilar, Gisela, Swetschinski, Lucien R, Ikuta, Kevin S, Mestrovic, Tomislav, Chung, Erin, Wool, Eve E, Han, Chieh, Gershberg Hayoon, Anna, Araki, Daniel T, Abd-Elsalam, Sherief, Aboagye, Richard Gyan, Adamu, Lawan Hassan, Adepoju, Abiola Victor, Ahmed, Ayman, Akalu, Gizachew Taddesse, Akande-Sholabi, Wuraola, Amuasi, John H, Amusa, Ganiyu Adeniyi, Argaw, Ayele Mamo, Aruleba, Raphael Taiwo, Awoke, Tewachew, Ayalew, Melese Kitu, Azzam, Ahmed Y, Babin, Francois-Xavier, Banerjee, Indrajit, Basiru, Afisu, Bayileyegn, Nebiyou Simegnew, Belete, Melaku Ashagrie, Berkley, James A, Bielicki, Julia A, Dekker, Denise, Demeke, Dessalegn, Demsie, Desalegn Getnet, Dessie, Anteneh Mengist, Dunachie, Susanna J, Ed-Dra, Abdelaziz, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, El Sayed, Iman, Elhadi, Muhammed, Elsohaby, Ibrahim, Eyre, David, Fagbamigbe, Adeniyi Francis, Feasey, Nicholas A, Fekadu, Ginenus, Fell, Frederick, Forrest, Karen M, Gebrehiwot, Mesfin, Gezae, Kebede Embaye, Ghazy, Ramy Mohamed, Hailegiyorgis, Tewodros Tesfa, Haines-Woodhouse, Georgina, Hasaballah, Ahmed I, Haselbeck, Andrea Haekyung, Hsia, Yingfen, Iradukunda, Arnaud, Iregbu, Kenneth Chukwuemeka, Iwu, Chidozie C D, Iwu-Jaja, Chinwe Juliana, Iyasu, Assefa N, Jaiteh, Fatoumatta, Jeon, Hyonjin, Joshua, Charity Ehimwenma, Kassa, Gebrehiwot G, Katoto, Patrick DMC, Krumkamp, Ralf, Kumaran, Emmanuelle A P, Kyu, Hmwe Hmwe, Manilal, Aseer, Marks, Florian, May, Jürgen, McLaughlin, Susan A, McManigal, Barney, Melese, Addisu, Misgina, Kebede Haile, Mohamed, Nouh Saad, Mohammed, Mustapha, Mohammed, Shafiu, Mohammed, Shikur, Mokdad, Ali H, Moore, Catrin E, Mougin, Vincent, Mturi, Neema, Mulugeta, Temesgen, Musaigwa, Fungai, Musicha, Patrick, Musila, Lillian A, Muthupandian, Saravanan, Naghavi, Pirouz, Negash, Hadush, Nuckchady, Dooshanveer C, Obiero, Christina W, Odetokun, Ismail A, Ogundijo, Oluwaseun Adeolu, Okidi, Lawrence, Okonji, Osaretin Christabel, Olagunju, Andrew T, Olufadewa, Isaac Iyinoluwa, Pak, Gi Deok, Perovic, Olga, Pollard, Andrew, Raad, Mathieu, Rafaï, Clotaire, Ramadan, Hazem, Redwan, Elrashdy Moustafa Mohamed, Roca, Anna, Rosenthal, Victor Daniel, Saleh, Mohamed A, Samy, Abdallah M, Sharland, M, Shittu, Aminu, Siddig, Emmanuel Edwar, Sisay, Eskinder Ayalew, Stergachis, Andy, Tesfamariam, Wegen Beyene, Tigoi, Caroline, Tincho, Marius Belmondo, Tiruye, Tenaw Yimer, Umeokonkwo, Chukwuma David, Walsh, Timothy, Walson, Judd L, Yusuf, Hadiza, Zeru, Naod Gebrekrstos, Hay, Simon I, Dolecek, Christiane, Murray, Christopher J L, and Naghavi, Mohsen

Published
2024
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3. Safety reporting in neonatal clinical trials: reflections towards optimal, globally relevant approaches.

Author

Hill, Louise F., Obiero, Christina W., Bekker, Adrie, Walker, Ann Sarah, Bielicki, Julia A., Sharland, Mike, and Schiavone, Francesca

Subjects
*PUBLIC health, *DRUG development, *MEDICAL sciences, *CLINICAL trials, *NEWBORN infants
Abstract

Adverse event (AE) collection is a key part of evidence generation in clinical trials and an integral element of safety reporting. AE assessment and documentation is particularly challenging in neonates who are a heterogeneous population with high rates of co-morbidities. Neonatal research is finally gaining the attention of regulators regarding drug development and the need for optimal dosing specific to this population. However, further efforts are necessary to ensure that adverse events (AEs) are adequately collected, allowing for the generation of essential safety data. It is also crucial that the methodology used aligns with the intended trial outcomes to minimise the burden on trial sites. In resource-constrained settings, where pharmacovigilance implementation can be particularly challenging, a pragmatic approach to safety reporting is even more important given the significant public health need for effective drugs. This commentary reflects on some of the challenges and potential areas of improvement in safety reporting that could be addressed in future neonatal-focused trials. [ABSTRACT FROM AUTHOR]

Published
2025
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4. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Author

Murray, Christopher J L, Ikuta, Kevin Shunji, Sharara, Fablina, Swetschinski, Lucien, Robles Aguilar, Gisela, Gray, Authia, Han, Chieh, Bisignano, Catherine, Rao, Puja, Wool, Eve, Johnson, Sarah C, Browne, Annie J, Chipeta, Michael Give, Fell, Frederick, Hackett, Sean, Haines-Woodhouse, Georgina, Kashef Hamadani, Bahar H, Kumaran, Emmanuelle A P, McManigal, Barney, Achalapong, Sureeruk, Agarwal, Ramesh, Akech, Samuel, Albertson, Samuel, Amuasi, John, Andrews, Jason, Aravkin, Aleskandr, Ashley, Elizabeth, Babin, François-Xavier, Bailey, Freddie, Baker, Stephen, Basnyat, Buddha, Bekker, Adrie, Bender, Rose, Berkley, James A, Bethou, Adhisivam, Bielicki, Julia, Boonkasidecha, Suppawat, Bukosia, James, Carvalheiro, Cristina, Castañeda-Orjuela, Carlos, Chansamouth, Vilada, Chaurasia, Suman, Chiurchiù, Sara, Chowdhury, Fazle, Clotaire Donatien, Rafai, Cook, Aislinn J, Cooper, Ben, Cressey, Tim R, Criollo-Mora, Elia, Cunningham, Matthew, Darboe, Saffiatou, Day, Nicholas P J, De Luca, Maia, Dokova, Klara, Dramowski, Angela, Dunachie, Susanna J, Duong Bich, Thuy, Eckmanns, Tim, Eibach, Daniel, Emami, Amir, Feasey, Nicholas, Fisher-Pearson, Natasha, Forrest, Karen, Garcia, Coralith, Garrett, Denise, Gastmeier, Petra, Giref, Ababi Zergaw, Greer, Rachel Claire, Gupta, Vikas, Haller, Sebastian, Haselbeck, Andrea, Hay, Simon I, Holm, Marianne, Hopkins, Susan, Hsia, Yingfen, Iregbu, Kenneth C, Jacobs, Jan, Jarovsky, Daniel, Javanmardi, Fatemeh, Jenney, Adam W J, Khorana, Meera, Khusuwan, Suwimon, Kissoon, Niranjan, Kobeissi, Elsa, Kostyanev, Tomislav, Krapp, Fiorella, Krumkamp, Ralf, Kumar, Ajay, Kyu, Hmwe Hmwe, Lim, Cherry, Lim, Kruy, Limmathurotsakul, Direk, Loftus, Michael James, Lunn, Miles, Ma, Jianing, Manoharan, Anand, Marks, Florian, May, Jürgen, Mayxay, Mayfong, Mturi, Neema, Munera-Huertas, Tatiana, Musicha, Patrick, Musila, Lilian A, Mussi-Pinhata, Marisa Marcia, Naidu, Ravi Narayan, Nakamura, Tomoka, Nanavati, Ruchi, Nangia, Sushma, Newton, Paul, Ngoun, Chanpheaktra, Novotney, Amanda, Nwakanma, Davis, Obiero, Christina W, Ochoa, Theresa J, Olivas-Martinez, Antonio, Olliaro, Piero, Ooko, Ednah, Ortiz-Brizuela, Edgar, Ounchanum, Pradthana, Pak, Gideok D, Paredes, Jose Luis, Peleg, Anton Yariv, Perrone, Carlo, Phe, Thong, Phommasone, Koukeo, Plakkal, Nishad, Ponce-de-Leon, Alfredo, Raad, Mathieu, Ramdin, Tanusha, Rattanavong, Sayaphet, Riddell, Amy, Roberts, Tamalee, Robotham, Julie Victoria, Roca, Anna, Rosenthal, Victor Daniel, Rudd, Kristina E, Russell, Neal, Sader, Helio S, Saengchan, Weerawut, Schnall, Jesse, Scott, John Anthony Gerard, Seekaew, Samroeng, Sharland, Mike, Shivamallappa, Madhusudhan, Sifuentes-Osornio, Jose, Simpson, Andrew J, Steenkeste, Nicolas, Stewardson, Andrew James, Stoeva, Temenuga, Tasak, Nidanuch, Thaiprakong, Areerat, Thwaites, Guy, Tigoi, Caroline, Turner, Claudia, Turner, Paul, van Doorn, H Rogier, Velaphi, Sithembiso, Vongpradith, Avina, Vongsouvath, Manivanh, Vu, Huong, Walsh, Timothy, Walson, Judd L, Waner, Seymour, Wangrangsimakul, Tri, Wannapinij, Prapass, Wozniak, Teresa, Young Sharma, Tracey E M W, Yu, Kalvin C, Zheng, Peng, Sartorius, Benn, Lopez, Alan D, Stergachis, Andy, Moore, Catrin, Dolecek, Christiane, and Naghavi, Mohsen

Published
2022
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5. Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS)

Author

Russell, Neal J., Stöhr, Wolfgang, Plakkal, Nishad, Cook, Aislinn, Berkley, James A., Adhisivam, Bethou, Agarwal, Ramesh, Ahmed, Nawshad Uddin, Balasegaram, Manica, Ballot, Daynia, Bekker, Adrie, Berezin, Eitan Naaman, Bilardi, Davide, Boonkasidecha, Suppawat, Carvalheiro, Cristina G., Chami, Neema, Chaurasia, Suman, Chiurchiu, Sara, Colas, Viviane Rinaldi Favarin, Cousens, Simon, Cressey, Tim R., de Assis, Ana Carolina Dantas, Dien, Tran Minh, Ding, Yijun, Dung, Nguyen Trong, Dong, Han, Dramowski, Angela, DS, Madhusudhan, Dudeja, Ajay, Feng, Jinxing, Glupczynski, Youri, Goel, Srishti, Goossens, Herman, Hao, Doan Thi Huong, Khan, Mahmudul Islam, Huertas, Tatiana Munera, Islam, Mohammad Shahidul, Jarovsky, Daniel, Khavessian, Nathalie, Khorana, Meera, Kontou, Angeliki, Kostyanev, Tomislav, Laoyookhon, Premsak, Lochindarat, Sorasak, Larsson, Mattias, Luca, Maia De, Malhotra-Kumar, Surbhi, Mondal, Nivedita, Mundhra, Nitu, Musoke, Philippa, Mussi-Pinhata, Marisa M., Nanavati, Ruchi, Nakwa, Firdose, Nangia, Sushma, Nankunda, Jolly, Nardone, Alessandra, Nyaoke, Borna, Obiero, Christina W., Owor, Maxensia, Ping, Wang, Preedisripipat, Kanchana, Qazi, Shamim, Qi, Lifeng, Ramdin, Tanusha, Riddell, Amy, Romani, Lorenza, Roysuwan, Praewpan, Saggers, Robin, Roilides, Emmanuel, Saha, Samir K., Sarafidis, Kosmas, Tusubira, Valerie, Thomas, Reenu, Velaphi, Sithembiso, Vilken, Tuba, Wang, Xiaojiao, Wang, Yajuan, Yang, Yonghong, Zunjie, Liu, Ellis, Sally, Bielicki, Julia A., Walker, A. Sarah, Heath, Paul T., and Sharland, Mike

Subjects
Diagnosis, Care and treatment, Prevention, Dosage and administration, Forecasts and trends, Market trend/market analysis, Infant mortality -- Forecasts and trends -- Prevention, Hospital patients -- Care and treatment, Antibiotics -- Dosage and administration, Sepsis -- Diagnosis -- Care and treatment, Infants -- Patient outcomes
Abstract

Author(s): Neal J. Russell 1,*, Wolfgang Stöhr 2, Nishad Plakkal 3, Aislinn Cook 1, James A. Berkley 4,5,6, Bethou Adhisivam 3, Ramesh Agarwal 7, Nawshad Uddin Ahmed 8, Manica Balasegaram [...], Background There is limited data on antibiotic treatment in hospitalized neonates in low- and middle-income countries (LMICs). We aimed to describe patterns of antibiotic use, pathogens, and clinical outcomes, and to develop a severity score predicting mortality in neonatal sepsis to inform future clinical trial design. Methods and findings Hospitalized infants A total of 3,204 infants were enrolled, with median birth weight of 2,500 g (IQR 1,400 to 3,000) and postnatal age of 5 days (IQR 1 to 15). 206 different empiric antibiotic combinations were started in 3,141 infants, which were structured into 5 groups based on the World Health Organization (WHO) AWaRe classification. Approximately 25.9% (n = 814) of infants started WHO first line regimens (Group 1-Access) and 13.8% (n = 432) started WHO second-line cephalosporins (cefotaxime/ceftriaxone) (Group 2-"Low" Watch). The largest group (34.0%, n = 1,068) started a regimen providing partial extended-spectrum beta-lactamase (ESBL)/pseudomonal coverage (piperacillin-tazobactam, ceftazidime, or fluoroquinolone-based) (Group 3-"Medium" Watch), 18.0% (n = 566) started a carbapenem (Group 4-"High" Watch), and 1.8% (n = 57) a Reserve antibiotic (Group 5, largely colistin-based), and 728/2,880 (25.3%) of initial regimens in Groups 1 to 4 were escalated, mainly to carbapenems, usually for clinical deterioration (n = 480; 65.9%). A total of 564/3,195 infants (17.7%) were blood culture pathogen positive, of whom 62.9% (n = 355) had a gram-negative organism, predominantly Klebsiella pneumoniae (n = 132) or Acinetobacter spp. (n = 72). Both were commonly resistant to WHO-recommended regimens and to carbapenems in 43 (32.6%) and 50 (71.4%) of cases, respectively. MRSA accounted for 33 (61.1%) of 54 Staphylococcus aureus isolates. Overall, 350/3,204 infants died (11.3%; 95% CI 10.2% to 12.5%), 17.7% if blood cultures were positive for pathogens (95% CI 14.7% to 21.1%, n = 99/564). A baseline NeoSep Severity Score had a C-index of 0.76 (0.69 to 0.82) in the validation sample, with mortality of 1.6% (3/189; 95% CI: 0.5% to 4.6%), 11.0% (27/245; 7.7% to 15.6%), and 27.3% (12/44; 16.3% to 41.8%) in low (score 0 to 4), medium (5 to 8), and high (9 to 16) risk groups, respectively, with similar performance across subgroups. A related NeoSep Recovery Score had an area under the receiver operating curve for predicting death the next day between 0.8 and 0.9 over the first week. There was significant variation in outcomes between sites and external validation would strengthen score applicability. Conclusion Antibiotic regimens used in neonatal sepsis commonly diverge from WHO guidelines, and trials of novel empiric regimens are urgently needed in the context of increasing antimicrobial resistance (AMR). The baseline NeoSep Severity Score identifies high mortality risk criteria for trial entry, while the NeoSep Recovery Score can help guide decisions on regimen change. NeoOBS data informed the NeoSep1 antibiotic trial (ISRCTN48721236), which aims to identify novel first- and second-line empiric antibiotic regimens for neonatal sepsis. Trial registration ClinicalTrials.gov, (NCT03721302).

Published
2023
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6. WHO global research priorities for antimicrobial resistance in human health

Author

Bertagnolio, Silvia, Dobreva, Zlatina, Centner, Chad M, Olaru, Ioana Diana, Donà, Daniele, Burzo, Stefano, Huttner, Benedikt D, Chaillon, Antoine, Gebreselassie, Nebiat, Wi, Teodora, Hasso-Agopsowicz, Mateusz, Allegranzi, Benedetta, Sati, Hatim, Ivanovska, Verica, Kothari, Kavita U, Balkhy, Hanan H, Cassini, Alessandro, Hamers, Raph L, Weezenbeek, Kitty Van, Aanensen, David, Alanio, Alexandre, Alastruey-Izquierdo, Ana, Alemayehu, Tinsae, Al-Hasan, Majdi, Allegaert, Karel, Al-Maani, Amal Saif, Al-Salman, Jameela, Alshukairi, Abeer Nizar, Amir, Afreenish, Applegate, Tanya, Araj, George F, Villalobos, Marlen Arce, Årdal, Christine, Ashiru-Oredope, Diane, Ashley, Elizabeth A, Babin, François-Xavier, Bachmann, Laura H, Bachmann, Till, Baker, Kate Susan, Balasegaram, Manica, Bamford, Colleen, Baquero, Fernando, Barcelona, Laura Isabel, Bassat, Quique, Bassetti, Matteo, Basu, Sulagna, Beardsley, Justin, Vásquez, Grey Benoit, Berkley, James A, Bhatnagar, Anuj K, Bielicki, Julia, Bines, Julie, Bongomin, Felix, Bonomo, Robert A, Bradley, John S, Bradshaw, Catriona, Brett, Ana, Brink, Adrian, Brown, Colin, Brown, Jeremy, Buising, Kirsty, Carson, Carolee, Carvalho, Anna Cristina, Castagnola, Elio, Cavaleri, Marco, Cecchini, Michele, Chabala, Chishala, Chaisson, Richard E, Chakrabarti, Arunaloke, Chandler, Clare, Chandy, Sujith John, Charani, Esmita, Chen, Lisa, Chiara, Francesca, Chowdhary, Anuradha, Chua, Arlene, Chuki, Pem, Chun, Doo Ryeon, Churchyard, Gavin, Cirillo, Daniela, Clack, Lauren, Coffin, Susan E, Cohn, Jennifer, Cole, Michelle, Conly, John, Cooper, Ben, Corso, Alejandra, Cosgrove, Sara E, Cox, Helen, Daley, Charles L, Darboe, Saffiatou, Darton, Tom, Davies, Gerry, de Egea, Viviana, Dedeić-Ljubović, Amela, Deeves, Miranda, Denkinger, Claudia, Dillon, Jo-Anne R, Dramowski, Angela, Eley, Brian, Roberta Esposito, Susanna Maria, Essack, Sabiha Y, Farida, Helmia, Farooqi, Joveria, Feasey, Nicholas, Ferreyra, Cecilia, Fifer, Helen, Finlayson, Heather, Frick, Mike, Gales, Ana Cristina, Galli, Luisa, Gandra, Sumanth, Gerber, Jeffrey S, Giske, Christian, Gordon, Bruce, Govender, Nelesh, Guessennd, Nathalie, Guindo, Ibrehima, Gurbanova, Elmira, Gwee, Amanda, Hagen, Ferry, Harbarth, Stephan, Haze, John, Heim, Jutta, Hendriksen, Rene, Heyderman, Robert Simon, Holt, Kathryn Elizabeth, Hönigl, Martin, Hook, Edward W, Hope, William, Hopkins, Heidi, Hughes, Gwenda, Ismail, Ghada, Issack, Mohammad Iqbal, Jacobs, Jan, Jasovský, Dušan, Jehan, Fyeza, Pearson, Antonieta Jimenez, Jones, Makoto, Joshi, Mohan P, Kapil, Arti, Kariuki, Samuel, Karkey, Abhilasha, Kearns, Gregory L, Keddy, Karen Helena, Khanna, Nina, Kitamura, Akiko, Kolho, Kaija-Leena, Kontoyiannis, Dimitrios P, Kotwani, Anita, Kozlov, Roman S, Kranzer, Katharina, Kularatne, Ranmini, Lahra, Monica M, Langford, Bradley J, Laniado-Laborin, Rafael, Larsson, Joakim, Lass-Flörl, Cornelia, Le Doare, Kirsty, Lee, Hyukmin, Lessa, Fernanda, Levin, Anna S, Limmathurotsakul, Direk, Lincopan, Nilton, Lo Vecchio, Andrea, Lodha, Rakesh, Loeb, Mark, Longtin, Yves, Lye, David Chien, Mahmud, Asif Mujtaba, Manaia, Célia, Manderson, Lenore, Mareković, Ivana, Marimuthu, Kalisvar, Martin, Irene, Mashe, Tapfumanei, Mei, Zeng, Meis, Jacques F, Lyra Tavares De Melo, Flávio Augusto, Mendelson, Marc, Miranda, Angelica Espinosa, Moore, David, Morel, Chantal, Moremi, Nyambura, Moro, Maria Luisa, Moussy, Francis, Mshana, Stephen, Mueller, Arno, Ndow, Francis J, Nicol, Mark, Nunn, Andrew, Obaro, Stephen, Obiero, Christina W, Okeke, Iruka N, Okomo, Uduak, Okwor, Tochi J, Oladele, Rita, Omulo, Sylvia, Ondoa, Pascale, Ortellado de Canese, Juana Medarda, Ostrosky-Zeichner, Luis, Padoveze, Maria Clara, Pai, Madhukar, Park, Benjamin, Parkhill, Julian, Parry, Christopher M, Peeling, Rosanna, Sobreira Vieira Peixe, Luísa Maria, Perovic, Olga, Pettigrew, Melinda M, Principi, Nicola, Pulcini, Céline, Puspandari, Nelly, Rawson, Timothy, Reddy, Denasha Lavanya, Reddy, Kessendri, Redner, Paulo, Rodríguez Tudela, Juan Luis, Rodríguez-Baño, Jesús, Van Katwyk, Susan Rogers, Roilides, Emmanuel, Rollier, Christine, Rollock, Leslie, Ronat, Jean-Baptiste, Ruppe, Etienne, Sadarangani, Manish, Salisbury, David, Salou, Mounerou, Samison, Luc Hervé, Sanguinetti, Maurizio, Sartelli, Massimo, Schellack, Natalie, Schouten, Jeroen, Schwaber, Mitchell J, Seni, Jeremiah, Senok, Abiola, Shafer, William M, Shakoor, Sadia, Sheppard, Donald, Shin, Jong-Hee, Sia, Sonia, Sievert, Dawn, Singh, Ishwar, Singla, Rupak, Skov, Robert Leo, Soge, Olusegun O, Sprute, Rosanne, Srinivasan, Arjun, Srinivasan, Subasree, Sundsfjord, Arnfinn, Tacconelli, Evelina, Tahseen, Sabira, Tangcharoensathien, Viroj, Tängdén, Thomas, Thursky, Karin, Thwaites, Guy, Tigulini de Souza Peral, Renata, Tong, Deborah, Tootla, Hafsah Deepa, Tsioutis, Constantinos, Turner, Katy M, Turner, Paul, Omar, Shaheed Vally, van de Sande, Wendy WJ, van den Hof, Susan, van Doorn, Rogier, Veeraraghavan, Balaji, Verweij, Paul, Wahyuningsih, Retno, Wang, Hui, Warris, Adilia, Weinstock, Hillard, Wesangula, Evelyn, Whiley, David, White, Peter J, Williams, Phoebe, Xiao, Yonghong, Moscoso, Martin Yagui, Yang, Hsu Li, Yoshida, Sachiyo, Yu, Yunsong, Żabicka, Dorota, Zignol, Matteo, Bertagnolio, Silvia, Dobreva, Zlatina, Centner, Chad M, Olaru, Ioana Diana, Donà, Daniele, Burzo, Stefano, Huttner, Benedikt D, Chaillon, Antoine, Gebreselassie, Nebiat, Wi, Teodora, Hasso-Agopsowicz, Mateusz, Allegranzi, Benedetta, Sati, Hatim, Ivanovska, Verica, Kothari, Kavita U, Balkhy, Hanan H, Cassini, Alessandro, Hamers, Raph L, Weezenbeek, Kitty Van, Aanensen, David, Alanio, Alexandre, Alastruey-Izquierdo, Ana, Alemayehu, Tinsae, Al-Hasan, Majdi, Allegaert, Karel, Al-Maani, Amal Saif, Al-Salman, Jameela, Alshukairi, Abeer Nizar, Amir, Afreenish, Applegate, Tanya, Araj, George F, Villalobos, Marlen Arce, Årdal, Christine, Ashiru-Oredope, Diane, Ashley, Elizabeth A, Babin, François-Xavier, Bachmann, Laura H, Bachmann, Till, Baker, Kate Susan, Balasegaram, Manica, Bamford, Colleen, Baquero, Fernando, Barcelona, Laura Isabel, Bassat, Quique, Bassetti, Matteo, Basu, Sulagna, Beardsley, Justin, Vásquez, Grey Benoit, Berkley, James A, Bhatnagar, Anuj K, Bielicki, Julia, Bines, Julie, Bongomin, Felix, Bonomo, Robert A, Bradley, John S, Bradshaw, Catriona, Brett, Ana, Brink, Adrian, Brown, Colin, Brown, Jeremy, Buising, Kirsty, Carson, Carolee, Carvalho, Anna Cristina, Castagnola, Elio, Cavaleri, Marco, Cecchini, Michele, Chabala, Chishala, Chaisson, Richard E, Chakrabarti, Arunaloke, Chandler, Clare, Chandy, Sujith John, Charani, Esmita, Chen, Lisa, Chiara, Francesca, Chowdhary, Anuradha, Chua, Arlene, Chuki, Pem, Chun, Doo Ryeon, Churchyard, Gavin, Cirillo, Daniela, Clack, Lauren, Coffin, Susan E, Cohn, Jennifer, Cole, Michelle, Conly, John, Cooper, Ben, Corso, Alejandra, Cosgrove, Sara E, Cox, Helen, Daley, Charles L, Darboe, Saffiatou, Darton, Tom, Davies, Gerry, de Egea, Viviana, Dedeić-Ljubović, Amela, Deeves, Miranda, Denkinger, Claudia, Dillon, Jo-Anne R, Dramowski, Angela, Eley, Brian, Roberta Esposito, Susanna Maria, Essack, Sabiha Y, Farida, Helmia, Farooqi, Joveria, Feasey, Nicholas, Ferreyra, Cecilia, Fifer, Helen, Finlayson, Heather, Frick, Mike, Gales, Ana Cristina, Galli, Luisa, Gandra, Sumanth, Gerber, Jeffrey S, Giske, Christian, Gordon, Bruce, Govender, Nelesh, Guessennd, Nathalie, Guindo, Ibrehima, Gurbanova, Elmira, Gwee, Amanda, Hagen, Ferry, Harbarth, Stephan, Haze, John, Heim, Jutta, Hendriksen, Rene, Heyderman, Robert Simon, Holt, Kathryn Elizabeth, Hönigl, Martin, Hook, Edward W, Hope, William, Hopkins, Heidi, Hughes, Gwenda, Ismail, Ghada, Issack, Mohammad Iqbal, Jacobs, Jan, Jasovský, Dušan, Jehan, Fyeza, Pearson, Antonieta Jimenez, Jones, Makoto, Joshi, Mohan P, Kapil, Arti, Kariuki, Samuel, Karkey, Abhilasha, Kearns, Gregory L, Keddy, Karen Helena, Khanna, Nina, Kitamura, Akiko, Kolho, Kaija-Leena, Kontoyiannis, Dimitrios P, Kotwani, Anita, Kozlov, Roman S, Kranzer, Katharina, Kularatne, Ranmini, Lahra, Monica M, Langford, Bradley J, Laniado-Laborin, Rafael, Larsson, Joakim, Lass-Flörl, Cornelia, Le Doare, Kirsty, Lee, Hyukmin, Lessa, Fernanda, Levin, Anna S, Limmathurotsakul, Direk, Lincopan, Nilton, Lo Vecchio, Andrea, Lodha, Rakesh, Loeb, Mark, Longtin, Yves, Lye, David Chien, Mahmud, Asif Mujtaba, Manaia, Célia, Manderson, Lenore, Mareković, Ivana, Marimuthu, Kalisvar, Martin, Irene, Mashe, Tapfumanei, Mei, Zeng, Meis, Jacques F, Lyra Tavares De Melo, Flávio Augusto, Mendelson, Marc, Miranda, Angelica Espinosa, Moore, David, Morel, Chantal, Moremi, Nyambura, Moro, Maria Luisa, Moussy, Francis, Mshana, Stephen, Mueller, Arno, Ndow, Francis J, Nicol, Mark, Nunn, Andrew, Obaro, Stephen, Obiero, Christina W, Okeke, Iruka N, Okomo, Uduak, Okwor, Tochi J, Oladele, Rita, Omulo, Sylvia, Ondoa, Pascale, Ortellado de Canese, Juana Medarda, Ostrosky-Zeichner, Luis, Padoveze, Maria Clara, Pai, Madhukar, Park, Benjamin, Parkhill, Julian, Parry, Christopher M, Peeling, Rosanna, Sobreira Vieira Peixe, Luísa Maria, Perovic, Olga, Pettigrew, Melinda M, Principi, Nicola, Pulcini, Céline, Puspandari, Nelly, Rawson, Timothy, Reddy, Denasha Lavanya, Reddy, Kessendri, Redner, Paulo, Rodríguez Tudela, Juan Luis, Rodríguez-Baño, Jesús, Van Katwyk, Susan Rogers, Roilides, Emmanuel, Rollier, Christine, Rollock, Leslie, Ronat, Jean-Baptiste, Ruppe, Etienne, Sadarangani, Manish, Salisbury, David, Salou, Mounerou, Samison, Luc Hervé, Sanguinetti, Maurizio, Sartelli, Massimo, Schellack, Natalie, Schouten, Jeroen, Schwaber, Mitchell J, Seni, Jeremiah, Senok, Abiola, Shafer, William M, Shakoor, Sadia, Sheppard, Donald, Shin, Jong-Hee, Sia, Sonia, Sievert, Dawn, Singh, Ishwar, Singla, Rupak, Skov, Robert Leo, Soge, Olusegun O, Sprute, Rosanne, Srinivasan, Arjun, Srinivasan, Subasree, Sundsfjord, Arnfinn, Tacconelli, Evelina, Tahseen, Sabira, Tangcharoensathien, Viroj, Tängdén, Thomas, Thursky, Karin, Thwaites, Guy, Tigulini de Souza Peral, Renata, Tong, Deborah, Tootla, Hafsah Deepa, Tsioutis, Constantinos, Turner, Katy M, Turner, Paul, Omar, Shaheed Vally, van de Sande, Wendy WJ, van den Hof, Susan, van Doorn, Rogier, Veeraraghavan, Balaji, Verweij, Paul, Wahyuningsih, Retno, Wang, Hui, Warris, Adilia, Weinstock, Hillard, Wesangula, Evelyn, Whiley, David, White, Peter J, Williams, Phoebe, Xiao, Yonghong, Moscoso, Martin Yagui, Yang, Hsu Li, Yoshida, Sachiyo, Yu, Yunsong, Żabicka, Dorota, and Zignol, Matteo

Abstract

The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.

Published
2024

8. Where do those data go? Reuse of screening results from clinical trials to estimate population prevalence of HBV infection in adults in Kilifi, Kenya

Author

Downs, Louise O., primary, Campbell, Cori, additional, Abouyannis, Michael, additional, Otiende, Mark, additional, Kapulu, Melissa, additional, Obiero, Christina W., additional, Hamaluba, Mainga, additional, Ngetsa, Caroline, additional, Andersson, Monique I., additional, Githinji, George, additional, Warimwe, George, additional, Baisley, Kathy, additional, Scott, J. Anthony G., additional, Matthews, Philippa C., additional, and Etyang, Anthony, additional

Published
2023
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9. Challenges in the Implementation of the NeoOBS Study, a Global Pragmatic Observational Cohort Study, to Investigate the Aetiology and Management of Neonatal Sepsis in the Hospital Setting

Author

Riddell, Amy, primary, Cook, Aislinn, additional, Khavessian, Nathalie, additional, Ellis, Sally, additional, Bilardi, Davide, additional, Correia, Erika, additional, Kostyanev, Tomislav, additional, Nardone, Alessandra, additional, Russell, Neal, additional, Vilken, Tuba, additional, Stohr, Wolfgang, additional, Adhisivam, Bethou, additional, Moraes, Iana Rosa Alves de, additional, Ahmed, Nawshad Uddin, additional, Bekker, Adrie, additional, Berezin, Eitan Naaman, additional, Boonkasidecha, Suppawat, additional, Carvalheiro, Cristina G., additional, Chauhan, Prachi, additional, Chiurchiù, Sara, additional, Chorafa, Elisavet, additional, Dramowski, Angela, additional, DS, Madhusudhan, additional, Feng, Jinxing, additional, Jia, Shengnan, additional, Kong, Yuan, additional, Kyohere, Mary, additional, Kontou, Angeliki, additional, Lochindarat, Sorasak, additional, De Luca, Maia, additional, Mphaphuli, Aripfani, additional, Mussi-Pinhata, Marisa M., additional, Murunga, Sheila, additional, Nakwa, Firdose Lambey, additional, Nangia, Sushma, additional, Nassolo, Erinah, additional, Hoang, Ngoc Thi Bin, additional, Obiero, Christina W., additional, Olson, Linus, additional, Ping, Wang, additional, Plakkal, Nishad, additional, Prasad, Priyanka, additional, Preedisripipat, Kanchana, additional, Rahman, Sheikh Wasik, additional, Seef, Tiffany, additional, Sukrakanchana, Pra-ornsuda, additional, Thomas, Reenu, additional, Yu, Zhang, additional, Zhang, Qiaoru, additional, Walker, A. Sarah, additional, Bielicki, Julia, additional, Heath, Paul T., additional, Sharland, Michael, additional, and Munera-Huertas, Tatiana, additional

Published
2023
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13. Complement-mediated serum bactericidal activity of antibodies elicited by the Shigella sonnei GMMA vaccine in adults from a shigellosis-endemic country: Exploratory analysis of a Phase 2a randomized study

Author

Kapulu, Melissa C., primary, Nakakana, Usman, additional, Sciré, Antonella S., additional, Sarakinou, Eleanna, additional, Conti, Valentino, additional, Rossi, Omar, additional, Acquaviva, Alessandra, additional, Necchi, Francesca, additional, Obiero, Christina W., additional, Martin, Laura B., additional, Bejon, Philip, additional, Njuguna, Patricia, additional, Micoli, Francesca, additional, and Podda, Audino, additional

Published
2022
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14. The NeoSep Severity and Recovery scores to predict mortality in hospitalized neonates and young infants with sepsis derived from the global NeoOBS observational cohort study

Author

Russell, Neal, primary, Stöhr, Wolfgang, additional, Cook, Aislinn, additional, Berkley, James A, additional, Adhisivam, Bethou, additional, Agarwal, Ramesh, additional, Ahmed, Nawshad Uddin, additional, Balasegaram, Manica, additional, Chami, Neema, additional, Bekker, Adrie, additional, Bilardi, Davide, additional, Carvalheiro, Cristina G., additional, Chaurasia, Suman, additional, Favarin Colas, Viviane Rinaldi, additional, Cousens, Simon, additional, Dantas de Assis, Ana Carolina, additional, Dong, Han, additional, Dramowski, Angela, additional, Dung, Nguyen Trong, additional, Feng, Jinxing, additional, Glupczynski, Youri, additional, Goel, Srishti, additional, Goossens, Herman, additional, Huong Hao, Doan Thi, additional, Hasan, Mahmudul, additional, Huertas, Tatiana Munera, additional, Khavessian, Nathalie, additional, Kontou, Angeliki, additional, Kostyanev, Tomislav, additional, Laoyookhon, Premsak, additional, Lochindarat, Sorasak, additional, De Luca, Maia, additional, Malhotra-Kumar, Surbhi, additional, Mondal, Nivedita, additional, Mundhra, Nitu, additional, Musoke, Philippa, additional, Mussi-Pinhata, Marisa M., additional, Nanavati, Ruchi, additional, Nakwa, Firdose L., additional, Nangia, Sushma, additional, Nardone, Alessandra, additional, Nyaoke, Borna, additional, Obiero, Christina W, additional, Ping, Wang, additional, Preedisripipat, Kanchana, additional, Qazi, Shamim, additional, Qi, Lifeng, additional, Riddell, Amy, additional, Romani, Lorenza, additional, Roysuwan, Praewpan, additional, Saggers, Robin, additional, Saha, Samir, additional, Sarafidis, Kosmas, additional, Tusibira, Valerie, additional, Velaphi, Sithembiso, additional, Vilken, Tuba, additional, Wang, Xiaojiao, additional, Wang, Yajuan, additional, Yang, Yonghong, additional, Ellis, Sally, additional, Bielicki, Julia, additional, Walker, A Sarah, additional, Heath, Paul T., additional, and Sharland, Mike, additional

Published
2022
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15. Patterns of antibiotic use, pathogens and clinical outcomes in hospitalised neonates and young infants with sepsis in the NeoOBS global neonatal sepsis observational cohort study

Author

Russell, Neal, primary, Stöhr, Wolfgang, additional, Plakkal, Nishad, additional, Cook, Aislinn, additional, Berkley, James A, additional, Adhisivam, Bethou, additional, Agarwal, Ramesh, additional, Balasegaram, Manica, additional, Ballot, Daynia, additional, Bekker, Adrie, additional, Berezin, Eitan Naaman, additional, Bilardi, Davide, additional, Boonkasidecha, Suppawat, additional, Carvalheiro, Cristina G., additional, Chaurasia, Suman, additional, Chiurchiu, Sara, additional, Cousens, Simon, additional, Cressey, Tim R., additional, Dien, Tran Minh, additional, Ding, Yijun, additional, Dramowski, Angela, additional, DS, Madhusudhan, additional, Dudeja, Ajay, additional, Feng, Jinxing, additional, Glupczynski, Youri, additional, Goossens, Herman, additional, Huertas, Tatiana Munera, additional, Islam, Mohammad Shahidul, additional, Jarovsky, Daniel, additional, Khavessian, Nathalie, additional, Khorana, Meera, additional, Kostyanev, Tomislav, additional, Larsson, Mattias, additional, Luca, Maia De, additional, Malhotra-Kumar, Surbhi, additional, Mussi-Pinhata, Marisa M., additional, Nanavati, Ruchi, additional, Nangia, Sushma, additional, Nankunda, Jolly, additional, Nardone, Alessandra, additional, Nyaoke, Borna, additional, Obiero, Christina W, additional, Owor, Maxensia, additional, Ping, Wang, additional, Preedisripipat, Kanchana, additional, Qazi, Shamim, additional, Ramdin, Tanusha, additional, Riddell, Amy, additional, Roilides, Emmanuel, additional, Saha, Samir K, additional, Sarafidis, Kosmas, additional, Thomas, Reenu, additional, Velaphi, Sithembiso, additional, Vilken, Tuba, additional, Wang, Yajuan, additional, Yang, Yonghong, additional, Zunjie, Liu, additional, Ellis, Sally, additional, Bielicki, Julia, additional, Walker, A Sarah, additional, Heath, Paul T., additional, and Sharland, Mike, additional

Published
2022
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16. Randomised controlled trial of fosfomycin in neonatal sepsis: pharmacokinetics and safety in relation to sodium overload

Author

Obiero, Christina W, primary, Williams, Phoebe, additional, Murunga, Sheila, additional, Thitiri, Johnstone, additional, Omollo, Raymond, additional, Walker, Ann Sarah, additional, Egondi, Thaddaeus, additional, Nyaoke, Borna, additional, Correia, Erika, additional, Kane, Zoe, additional, Gastine, Silke, additional, Kipper, Karin, additional, Standing, Joseph F, additional, Ellis, Sally, additional, Sharland, Mike, additional, and Berkley, James Alexander, additional

Published
2022
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17. Answer to Paredes et al. commenting on “COVID-19 vaccines under the International Health Regulations — We must use the WHO International Certificate of Vaccination or Prophylaxis”

Author

Petersen, Eskild, primary, Lucey, Daniel, additional, Blumberg, Lucille, additional, Kramer, Laura D., additional, Al-Abri, Seif, additional, Lee, Shui Shan, additional, Pinto, Tatiana de Castro Abreu, additional, Obiero, Christina W., additional, Rodriguez-Morales, Alfonso J., additional, Yapi, Richard, additional, Abubakar, Aisha, additional, Tambyah, Paul Anantharajah, additional, Holmes, Allison, additional, and Chen, Lin H., additional

Published
2021
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18. Complement-mediated serum bactericidal activity of antibodies elicited by the Shigella sonnei GMMA vaccine in adults from a shigellosisendemic country: Exploratory analysis of a Phase 2a randomized study.

Author

Kapulu, Melissa C., Nakakana, Usman, Sciré, Antonella S., Sarakinou, Eleanna, Conti, Valentino, Rossi, Omar, Acquaviva, Alessandra, Necchi, Francesca, Obiero, Christina W., Martin, Laura B., Bejon, Philip, Njuguna, Patricia, Micoli, Francesca, and Podda, Audino

Subjects
NEUTRALIZATION tests, ORAL rehydration therapy, SHIGELLA, IMMUNOGLOBULINS, IMMUNOGLOBULIN G, ENZYME-linked immunosorbent assay, KENYANS
Abstract

Shigella is associated with a significant burden of disease worldwide among individuals of all ages and is the major cause of moderate and severe diarrhea in children under five years of age in low- and middle-income countries. Several candidate vaccines against Shigella species are currently under clinical development. The investigational 1790GAHB vaccine against Shigella sonnei is based on GMMA (Generalized Modules for Membrane Antigens) technology. The vaccine was well tolerated and induced high antibody levels in early-phase clinical trials in both Shigella-endemic and non-endemic settings. The present analysis assessed the bactericidal activity of antibodies induced by 1790GAHB in healthy Kenyan adults during a phase 2a, controlled, randomized study (NCT02676895). Participants received two doses of 1790GAHB 4 weeks apart containing either 1.5/25 µg or 6/100 µg O antigen/protein, or active comparator vaccines (Control). Serum bactericidal activity (SBA) against S. sonnei was assessed at pre-vaccination (D1), 28 days post-first dose (D29) and 28 days post-second dose (D57), using a luminescence-based assay. Most participants had SBA titers above the lower limit of quantification of the assay at D1. SBA geometric mean titers increased 3.4-fold in the 1.5/25 µg group and 6.3-fold in the 6/100 µg group by D29 and were maintained at D57. There was no increase in SBA geometric mean titers in the Control group. A strong correlation was observed between SBA titers and anti-S. sonnei lipopolysaccharide serum immunoglobulin G antibody concentrations (Pearson correlation coefficient = 0.918), indicating that SBA can effectively complement enzyme-linked immunosorbent assay data by indicating the functionality of 1790GAHB-induced antibodies. [ABSTRACT FROM AUTHOR]

Published
2022
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19. COVID-19 vaccines under the International Health Regulations – We must use the WHO International Certificate of Vaccination or Prophylaxis

Author

Petersen, Eskild, primary, Lucey, Daniel, additional, Blumberg, Lucille, additional, Kramer, Laura D., additional, Al-Abri, Seif, additional, Lee, Shui Shan, additional, Pinto, Tatiana de Castro Abreu, additional, Obiero, Christina W., additional, Rodriguez-Morales, Alfonso J., additional, Yapi, Richard, additional, Abubakar, Aisha, additional, Tambyah, Paul Anantharajah, additional, Holmes, Allison, additional, and Chen, Lin H., additional

Published
2021
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20. Clinical Presentation and 28-Day Mortality in Hospitalized Neonates and Young Infants with Clinical Sepsis: The Global NeoOBS Observational Cohort

Author

Russell, Neal, primary, Stöhr, Wolfgang, additional, Plakkal, Nishad, additional, Cook, Aislinn, additional, Berkley, James A., additional, Adhisivam, Bethou, additional, Agarwal, Ramesh, additional, Balasegaram, Manica, additional, Ballot, Daynia, additional, Bekker, Adrie, additional, Berezin, Eitan Naaman, additional, Bilardi, Davide, additional, Boonkasidecha, Suppawat, additional, Carvalheiro, Cristina G., additional, Chaurasia, Suman, additional, Chiurchiu, Sara, additional, Cousens, Simon, additional, Cressey, Tim R., additional, Dien, Trah Minh, additional, Ding, Yijun, additional, Dramowski, Angela, additional, DS, Madhusudhan, additional, Dudeja, Ajay, additional, Feng, Jinxing, additional, Glupczynski, Youri, additional, Goossens, Herman, additional, Islam, Mohammad Shahidul, additional, Jarovsky, Daniel, additional, Khavessian, Nathalie, additional, Khorona, Meera, additional, Kostyanev, Tomislav, additional, Larsson, Matthias, additional, Luca, Maia De, additional, Malhotra-Kumar, Surbhi, additional, Mussi-Pinhata, Marisa M., additional, Nanavati, Ruchi, additional, Nangia, Sushma, additional, Nankunda, Jolly, additional, Nyaoke, Borna, additional, Obiero, Christina W., additional, Owor, Maxensia, additional, Ping, Wang, additional, Preedisripipat, Kanchana, additional, Qazi, Shamim, additional, Ramdin, Tanusha, additional, Riddell, Amy, additional, Roilides, Emmanuel, additional, Saha, Samir, additional, Sarafidis, Kosmas, additional, Thomas, Reenu, additional, Velaphi, Sithembiso Christopher, additional, Vilken, Tuba, additional, Wang, Yajuan, additional, Yang, Yonghong, additional, Zunjie, Liu, additional, Ellis, Sally, additional, Bielicki, Julia, additional, Walker, Sarah, additional, Heath, Paul T., additional, and Sharland, Mike, additional

Published
2021
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21. Analysis from the NeoOBS Global Neonatal Sepsis Prospective Observational Cohort Study Across 19 Hospitals in 11 Countries; Clinical Presentation, Treatment, Mortality Outcomes and Development of the NeoSEP Sepsis Severity Score

Author

Russell, Neal, primary, Stöhr, Wolfgang, additional, Plakkal, Nishad, additional, Cook, Aislinn, additional, Berkley, James A., additional, Adhisivam, Bethou, additional, Agarwal, Ramesh, additional, Balasegaram, Manica, additional, Ballot, Daynia, additional, Bekker, Adrie, additional, Berezin, Eitan Naaman, additional, Bilardi, Davide, additional, Boonkasidecha, Suppawat, additional, Carvalheiro, Cristina G., additional, Chaurasia, Suman, additional, Chiurchiu, Sara, additional, Cousens, Simon, additional, Cressey, Tim R., additional, Dien, Trah Minh, additional, Ding, Yijun, additional, Dramowski, Angela, additional, Ds, Madhusudhan, additional, Dudeja, Ajay, additional, Feng, Jinxing, additional, Glupczynski, Youri, additional, Goossens, Herman, additional, Islam, Mohammad Shahidul, additional, Jarovsky, Daniel, additional, Khavessian, Nathalie, additional, Khorona, Meera, additional, Kostyanev, Tomislav, additional, Larsson, Matthias, additional, Luca, Maia De, additional, Malhotra-Kumar, Surbhi, additional, Mussi-Pinhata, Marisa M., additional, Nanavati, Ruchi, additional, Nangia, Sushma, additional, Nankunda, Jolly, additional, Nyaoke, Borna, additional, Obiero, Christina W., additional, Owor, Maxensia, additional, Ping, Wang, additional, Preedisripipat, Kanchana, additional, Qazi, Shamim, additional, Ramdin, Tanusha, additional, Riddell, Amy, additional, Roilides, Emmanuel, additional, Saha, Samir, additional, Sarafidis, Kosmas, additional, Thomas, Reenu, additional, Velaphi, Sithembiso Christopher, additional, Vilken, Tuba, additional, Wang, Yajuan, additional, Yang, Yonghong, additional, Zunjie, Liu, additional, Ellis, Sally, additional, Bielicki, Julia, additional, Walker, Sarah, additional, Heath, Paul T., additional, and Sharland, Mike, additional

Published
2021
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23. Clinical features to distinguish meningitis among young infants at a rural Kenyan hospital.

Author

Obiero, Christina W., Mturi, Neema, Mwarumba, Salim, Ngari, Moses, Newton, Charles, van Hensbroek, Michael Boele, Berkley, James Alexander, and Boele van Hensbroek, Michael

Subjects
MENINGITIS, RURAL hospitals, HEALTH facilities, INFANTS, MIDDLE-income countries, RESEARCH, RURAL health services, RESEARCH methodology, RETROSPECTIVE studies, EVALUATION research, MEDICAL cooperation, BACTERIAL meningitis, COMPARATIVE studies, CHILD health services, DISEASE prevalence, RESEARCH funding, ROUTINE diagnostic tests, LONGITUDINAL method
Abstract

Background: Detection of meningitis is essential to optimise the duration and choice of antimicrobial agents to limit mortality and sequelae. In low and middle-income countries most health facilities lack laboratory capacity and rely on clinical features to empirically treat meningitis.Objective: We conducted a diagnostic validation study to investigate the performance of clinical features (fever, convulsions, irritability, bulging fontanel and temperature ≥39°C) and WHO-recommended signs (drowsiness, lethargy, unconsciousness, convulsions, bulging fontanel, irritability or a high-pitched cry) in discriminating meningitis in young infants.Design: Retrospective cohort study.Setting: Kilifi County Hospital.Patients: Infants aged <60 days hospitalised between 2012 and 2016.Main Outcome Measure: Definite meningitis defined as positive cerebrospinal fluid (CSF) culture, microscopy or antigen test, or leucocytes ≥0.05 x 10∧9/L.Results: Of 4809 infants aged <60 days included, 81 (1.7%) had definite meningitis. WHO-recommended signs had sensitivity of 58% (95% CI 47% to 69%) and specificity of 57% (95% CI 56% to 59%) for definite meningitis. Addition of history of fever improved sensitivity to 89% (95% CI 80% to 95%) but reduced specificity to 26% (95% CI 25% to 27%). Presence of ≥1 of 5 previously identified signs had sensitivity of 79% (95% CI 69% to 87%) and specificity of 51% (95% CI 50% to 53%).Conclusions: Despite a lower prevalence of definite meningitis, the performance of previously identified signs at admission in predicting meningitis was unchanged. Presence of history of fever improves the sensitivity of WHO-recommended signs but loses specificity. Careful evaluation, repeated assessment and capacity for lumbar puncture and CSF microscopy to exclude meningitis in most young infants with potential signs are essential to management in this age group. [ABSTRACT FROM AUTHOR]

Published
2021
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24. A Phase 2a Randomized Study to Evaluate the Safety and Immunogenicity of the 1790GAHB Generalized Modules for Membrane Antigen Vaccine against Shigella sonnei Administered Intramuscularly to Adults from a Shigellosis-Endemic Country

Author

Obiero, Christina W., primary, Ndiaye, Augustin G. W., additional, Sciré, Antonella Silvia, additional, Kaunyangi, Bonface M., additional, Marchetti, Elisa, additional, Gone, Ann M., additional, Schütte, Lena Dorothee, additional, Riccucci, Daniele, additional, Auerbach, Joachim, additional, Saul, Allan, additional, Martin, Laura B., additional, Bejon, Philip, additional, Njuguna, Patricia, additional, and Podda, Audino, additional

Published
2017
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25. Should first-line empiric treatment strategies cover coagulase-negative staphylococcal infections in severely malnourished or HIV-infected children in Kenya?

Author

Obiero, Christina W., primary, Seale, Anna C., additional, Jones, Kelsey, additional, Ngari, Moses, additional, Bendon, Charlotte L., additional, Morpeth, Susan, additional, Mohammed, Shebe, additional, Mturi, Neema, additional, Fegan, Greg, additional, and Berkley, James A., additional

Published
2017
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28. Additional file 1 of Clinical features of bacterial meningitis among hospitalised children in Kenya

Author

Obiero, Christina W., Mturi, Neema, Mwarumba, Salim, Ngari, Moses, Newton, Charles R., van Hensbroek, Michaël Boele, and Berkley, James A.

Subjects
3. Good health
Abstract

Additional file 1: Table S1. Comparison of annual admissions, lumbar punctures and meningitis cases during our study period and our previous analysis. Table S2. Sensitivity Analysis of Potential Screening Criteria at Admission for Meningitis.

29. Additional file 1 of Clinical features of bacterial meningitis among hospitalised children in Kenya

Author

Obiero, Christina W., Mturi, Neema, Mwarumba, Salim, Ngari, Moses, Newton, Charles R., van Hensbroek, Michaël Boele, and Berkley, James A.

Subjects
3. Good health
Abstract

Additional file 1: Table S1. Comparison of annual admissions, lumbar punctures and meningitis cases during our study period and our previous analysis. Table S2. Sensitivity Analysis of Potential Screening Criteria at Admission for Meningitis.

30. Effect of tropical climates on the quality of commonly used antibiotics: the protocol for a systematic review and meta-analysis.

Author

Suleman S, Hasen G, Melaku T, Belew S, Thitiri J, Shangala J, Obiero CW, Ngari M, and Berkley JA

Subjects
Meta-Analysis as Topic, Research Design, Systematic Reviews as Topic, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents standards, Drug Storage standards, Tropical Climate adverse effects
Abstract

Introduction: Medicine quality can be influenced by environmental factors. In low- and middle-income countries (LMICs) with tropical climates, storage facilities of medicines in healthcare settings and homes may be suboptimal. However, knowledge of the effects of temperature and other climatic and environmental factors on the quality of medicines is limited. A better understanding of the effects of climates may assist in the development of control strategies to help reduce factors contributing to poor-quality medicines. Therefore, this systematic review aims to synthesise data from published studies describing the effects of storage conditions on the quality of antibiotic medicines commonly used in LMICs., Methods and Analysis: We will search literature from databases, including the PubMed, Web of Science, Scopus and Google Scholar, and grey literature between 1987 and 2022. Experimental studies that evaluate the influence of temperature, humidity and sunlight on the quality of antibiotics applicable to Africa and South Asia will be included. Experimental studies that assess naturally occurring and simulated storage conditions and medicines prepared from powder with water and stored in hospitals or at home to be used across several doses will be also included. The key search terms related to the tropical climate, quality and commonly used antibiotics, such as temperature, storage condition, humidity, sunlight and moisture; quality, assay, purity, dissolution, disintegration, hardness, friability, weight variation, weight uniformity, degradation, impurities and stability; and amoxicillin, ceftriaxone, azithromycin, ciprofloxacin, doxycycline, metronidazole, trimethoprim-sulfamethoxazole, erythromycin, ampicillin and gentamicin, respectively, will be connected using the appropriate Boolean operators (OR, AND). The search terms will be used in correspondence with Medical Subject Heading terms by keyword arrangement. The available evidence for the poor quality of commonly used antibiotics is summarised by the type of diagnosis, type of drug and region. Meta-analysis using random effects will be performed using RevMan software to determine the pooled effects of environmental exposures. The degree of heterogeneity will be evaluated by the inverse of variance (I 2 ). Forest plots will be used to present the meta-analysis data., Ethics and Dissemination: Ethical approval is not required as the study is a systematic review. This review will be disseminated through open-access peer-reviewed publication., Prospero Registration Number: CRD42023432848., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.)

Published
2025
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