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2. Correction to: Toxicogenomics directory of chemically exposed human hepatocytes

Author

Grinberg, Marianna, Stöber, Regina M., Edlund, Karolina, Rempel, Eugen, Godoy, Patricio, Reif, Raymond, Widera, Agata, Madjar, Katrin, Schmidt-Heck, Wolfgang, Marchan, Rosemarie, Sachinidis, Agapios, Spitkovsky, Dimitry, Hescheler, Jürgen, Carmo, Helena, Arbo, Marcelo D., van de Water, Bob, Wink, Steven, Vinken, Mathieu, Rogiers, Vera, Escher, Sylvia, Hardy, Barry, Mitic, Dragana, Apic, Gordana, Myatt, Glenn, Waldmann, Tanja, Mardinoglu, Adil, Damm, Georg, Seehofer, Daniel, Nüssler, Andreas, Weiss, Thomas S., Oberemm, Axel, Lampen, ·Alfons, Schaap, Mirjam M., Luijten, Mirjam, van Steeg, Harry, Thasler, Wolfgang E., Kleinjans, Jos C. S., Stierum, Rob H., Leist, ·Marcel, Rahnenführer, Jörg, and Hengstler, Jan G.

Published
2022
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6. Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

Author

Albrecht, Wiebke, Kappenberg, Franziska, Brecklinghaus, Tim, Stoeber, Regina, Marchan, Rosemarie, Zhang, Mian, Ebbert, Kristina, Kirschner, Hendrik, Grinberg, Marianna, Leist, Marcel, Moritz, Wolfgang, Cadenas, Cristina, Ghallab, Ahmed, Reinders, Jörg, Vartak, Nachiket, van Thriel, Christoph, Golka, Klaus, Tolosa, Laia, Castell, José V., Damm, Georg, Seehofer, Daniel, Lampen, Alfonso, Braeuning, Albert, Buhrke, Thorsten, Behr, Anne-Cathrin, Oberemm, Axel, Gu, Xiaolong, Kittana, Naim, van de Water, Bob, Kreiling, Reinhard, Fayyaz, Susann, van Aerts, Leon, Smedsrød, Bård, Ellinger-Ziegelbauer, Heidrun, Steger-Hartmann, Thomas, Gundert-Remy, Ursula, Zeigerer, Anja, Ullrich, Anett, Runge, Dieter, Lee, Serene M. L., Schiergens, Tobias S., Kuepfer, Lars, Aguayo-Orozco, Alejandro, Sachinidis, Agapios, Edlund, Karolina, Gardner, Iain, Rahnenführer, Jörg, and Hengstler, Jan G.

Published
2019
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8. Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes

Author

Grinberg, Marianna, Stöber, Regina M., Albrecht, Wiebke, Edlund, Karolina, Schug, Markus, Godoy, Patricio, Cadenas, Cristina, Marchan, Rosemarie, Lampen, Alfonso, Braeuning, Albert, Buhrke, Thorsten, Leist, Marcel, Oberemm, Axel, Hellwig, Birte, Kamp, Hennicke, Gardner, Iain, Escher, Sylvia, Taboureau, Olivier, Aguayo-Orozco, Alejandro, Sachinidis, Agapios, Ellinger-Ziegelbauer, Heidrun, Rahnenführer, Jörg, and Hengstler, Jan G.

Published
2018
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13. Application of human biomonitoring to assess occupational exposure to polycyclic aromatic hydrocarbons in Europe: a literature review

Author

Louro, Henriqueta, Gomes, Bruno Costa, Saber, Anne Thoustrup, Iamiceli, Anna Laura, Göen, Thomas, Jones, Kate, Katsonouri, Andromachi, Neophytou, Christiana, Vogel, Ulla, Ventura, Célia, Oberemm, Axel, Duca, Radu Corneliu, Fernandez, Mariana F., Olea, Nicolas, Santonen, Tiina, Viegas, Susana, and Silva, Maria João

Subjects
Exposição Humana, Saúde Ocupacional, Hidrocarbonetos Aromáticos Policíclicos, Genotoxicidade Ambiental, Biomonitorização Humana, Europa
Abstract

Os hidrocarbonetos aromáticos policíclicos (HAPs) são produtos químicos com impacto em saúde ocupacional, pelo que a avaliação da exposição humana através de estudos de biomonitorização tem aumentado nos últimos anos. No entanto, os dados obtidos são ainda insuficientes para os reguladores e decisores políticos. Este trabalho, no contexto da Iniciativa Europeia em Biomonitorização Humana (HBM4EU), descreve uma revisão da literatura sobre a exposição ocupacional aos HAPs na Europa, entre 2008 e 2022, com o objetivo de identificar as vantagens e limitações dos vários biomarcadores de exposição e /ou de efeito, bem como o conhecimento em falta para melhorar a regulamentação. Os resultados da análise dos 42 artigos elegíveis para inclusão nesta revisão demonstram que o biomarcador de exposição mais utilizado é o 1-hidroxipireno urinário, sendo os biomarcadores de efeito mais comuns, biomarcadores de stresse oxidativo e genotoxicidade. Globalmente, verificou-se a necessidade de desenvolver novas abordagens de recolha de dados e amostras, bem como a seleção apropriada de biomarcadores de forma a obter dados fiáveis e comparáveis em diferentes setores industriais. Além disso, a aplicação de biomarcadores de efeito contribui para a identificação de ambientes de trabalho ou atividades de alto risco, possibilitando medidas de mitigação e gestão de risco. Polycyclic aromatic hydrocarbons (PAHs) are chemicals with impact on occupational health, therefore the assessment of human exposure using biomonitoring has increased in recent years. However, the data obtained are still insufficient to be useful to regulators and policy makers. This work, in the context of the Human Biomonitoring for Europe Initiative (HBM4EU), describes a review of the literature on occupational exposure to PAHs in Europe, between 2008 and 2022, with the aim of identifying the advantages and limitations of the various biomarkers of exposure and/or effect, as well as the missing knowledge to improve regulation in occupational settings. The results of the analysis of the 42 articles eligible for inclusion in this review demonstrate that the most used biomarker of exposure is urinary 1-hydroxypyrene, with the most common biomarkers of effect being the measurement of oxidative stress and genotoxicity. Overall, it was noted the need to develop new approaches to samples and data collection, as well as the appropriate selection of biomarkers in order to obtain reliable and comparable data in different industrial sectors. In addition, the application of effect biomarkers contributes to the identification of high-risk work environments or activities, enabling measures of risk mitigation and management. Este estudo recebeu financiamento do programa de investigação e inovação Horizonte 2020 da União Europeia sob o acordo de subvenção n.º 733032 e recebeu cofinanciamento das organizações dos autores. info:eu-repo/semantics/publishedVersion

Published
2022

14. A Comprehensive Review

Author

Louro, Henriqueta, Gomes, Bruno Costa, Saber, Anne Thoustrup, Iamiceli, Anna Laura, Göen, Thomas, Jones, Kate, Katsonouri, Andromachi, Neophytou, Christiana M, Vogel, Ulla, Ventura, Célia, Oberemm, Axel, Duca, Radu Corneliu, Fernandez, Mariana F, Olea, Nicolas, Santonen, Tiina, Viegas, Susana, Silva, Maria João, Centre for Toxicogenomics and Human Health (ToxOmics), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Escola Nacional de Saúde Pública (ENSP), Centro de Investigação em Saúde Pública (CISP/PHRC), and Comprehensive Health Research Centre (CHRC) - Pólo ENSP

Subjects
exposure biomarker, effect biomarker, SDG 3 - Good Health and Well-being, human biomonitoring, polycyclic aromatic hydrocarbons, occupational exposure
Abstract

Funding: This project has received funding from the European Unions’ Horizon 2020 research and innovation Programme under grant agreement No 733032. HBM4EU. Polycyclic aromatic hydrocarbons (PAHs) are among the chemicals with proven impact on workers' health. The use of human biomonitoring (HBM) to assess occupational exposure to PAHs has become more common in recent years, but the data generated need an overall view to make them more usable by regulators and policymakers. This comprehensive review, developed under the Human Biomonitoring for Europe (HBM4EU) Initiative, was based on the literature available from 2008-2022, aiming to present and discuss the information on occupational exposure to PAHs, in order to identify the strengths and limitations of exposure and effect biomarkers and the knowledge needs for regulation in the workplace. The most frequently used exposure biomarker is urinary 1-hydroxypyrene (1-OH-PYR), a metabolite of pyrene. As effect biomarkers, those based on the measurement of oxidative stress (urinary 8-oxo-dG adducts) and genotoxicity (blood DNA strand-breaks) are the most common. Overall, a need to advance new harmonized approaches both in data and sample collection and in the use of appropriate biomarkers in occupational studies to obtain reliable and comparable data on PAH exposure in different industrial sectors, was noted. Moreover, the use of effect biomarkers can assist to identify work environments or activities of high risk, thus enabling preventive risk mitigation and management measures. publishersversion published

Published
2022

16. The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review

Author

Louro, Henriqueta, primary, Gomes, Bruno Costa, additional, Saber, Anne Thoustrup, additional, Iamiceli, Anna Laura, additional, Göen, Thomas, additional, Jones, Kate, additional, Katsonouri, Andromachi, additional, Neophytou, Christiana M., additional, Vogel, Ulla, additional, Ventura, Célia, additional, Oberemm, Axel, additional, Duca, Radu Corneliu, additional, Fernandez, Mariana F., additional, Olea, Nicolas, additional, Santonen, Tiina, additional, Viegas, Susana, additional, and Silva, Maria João, additional

Published
2022
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17. Toxicogenomics directory of chemically exposed human hepatocytes (vol 88, pg 2261, 2014)

Author

Grinberg, Marianna, Stoeber, Regina M., Edlund, Karolina, Rempel, Eugen, Godoy, Patricio, Reif, Raymond, Widera, Agata, Madjar, Katrin, Schmidt-Heck, Wolfgang, Marchan, Rosemarie, Sachinidis, Agapios, Spitkovsky, Dimitry, Hescheler, Juergen, Carmo, Helena, Arbo, Marcelo D., van de Water, Bob, Wink, Steven, Vinken, Mathieu, Rogiers, Vera, Escher, Sylvia, Hardy, Barry, Mitic, Dragana, Apic, Gordana, Myatt, Glenn, Waldmann, Tanja, Mardinoglu, Adil, Damm, Georg, Seehofer, Daniel, Nuessler, Andreas, Weiss, Thomas S., Oberemm, Axel, Lampen, Alfons, Schaap, Mirjam M., Luijten, Mirjam, van Steeg, Harry, Thasler, Wolfgang E., Kleinjans, Jos C. S., Stierum, Rob H., Leist, Marcel, Rahnenfuehrer, Joerg, Hengstler, Jan G., Grinberg, Marianna, Stoeber, Regina M., Edlund, Karolina, Rempel, Eugen, Godoy, Patricio, Reif, Raymond, Widera, Agata, Madjar, Katrin, Schmidt-Heck, Wolfgang, Marchan, Rosemarie, Sachinidis, Agapios, Spitkovsky, Dimitry, Hescheler, Juergen, Carmo, Helena, Arbo, Marcelo D., van de Water, Bob, Wink, Steven, Vinken, Mathieu, Rogiers, Vera, Escher, Sylvia, Hardy, Barry, Mitic, Dragana, Apic, Gordana, Myatt, Glenn, Waldmann, Tanja, Mardinoglu, Adil, Damm, Georg, Seehofer, Daniel, Nuessler, Andreas, Weiss, Thomas S., Oberemm, Axel, Lampen, Alfons, Schaap, Mirjam M., Luijten, Mirjam, van Steeg, Harry, Thasler, Wolfgang E., Kleinjans, Jos C. S., Stierum, Rob H., Leist, Marcel, Rahnenfuehrer, Joerg, and Hengstler, Jan G.

Published
2022

18. The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe:A Comprehensive Review

Author

Louro, Henriqueta, Gomes, Bruno Costa, Saber, Anne Thoustrup, Iamiceli, Anna Laura, Göen, Thomas, Jones, Kate, Katsonouri, Andromachi, Neophytou, Christiana M., Vogel, Ulla, Ventura, Célia, Oberemm, Axel, Duca, Radu Corneliu, Fernandez, Mariana F., Olea, Nicolas, Santonen, Tiina, Viegas, Susana, Silva, Maria João, Louro, Henriqueta, Gomes, Bruno Costa, Saber, Anne Thoustrup, Iamiceli, Anna Laura, Göen, Thomas, Jones, Kate, Katsonouri, Andromachi, Neophytou, Christiana M., Vogel, Ulla, Ventura, Célia, Oberemm, Axel, Duca, Radu Corneliu, Fernandez, Mariana F., Olea, Nicolas, Santonen, Tiina, Viegas, Susana, and Silva, Maria João

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are among the chemicals with proven impact on workers' health. The use of human biomonitoring (HBM) to assess occupational exposure to PAHs has become more common in recent years, but the data generated need an overall view to make them more usable by regulators and policymakers. This comprehensive review, developed under the Human Biomonitoring for Europe (HBM4EU) Initiative, was based on the literature available from 2008-2022, aiming to present and discuss the information on occupational exposure to PAHs, in order to identify the strengths and limitations of exposure and effect biomarkers and the knowledge needs for regulation in the workplace. The most frequently used exposure biomarker is urinary 1-hydroxypyrene (1-OH-PYR), a metabolite of pyrene. As effect biomarkers, those based on the measurement of oxidative stress (urinary 8-oxo-dG adducts) and genotoxicity (blood DNA strand-breaks) are the most common. Overall, a need to advance new harmonized approaches both in data and sample collection and in the use of appropriate biomarkers in occupational studies to obtain reliable and comparable data on PAH exposure in different industrial sectors, was noted. Moreover, the use of effect biomarkers can assist to identify work environments or activities of high risk, thus enabling preventive risk mitigation and management measures.

Published
2022

19. Toxicogenomics directory of chemically exposed human hepatocytes

Author

Grinberg, Marianna, Stöber, Regina M., Edlund, Karolina, Rempel, Eugen, Godoy, Patricio, Reif, Raymond, Widera, Agata, Madjar, Katrin, Schmidt-Heck, Wolfgang, Marchan, Rosemarie, Sachinidis, Agapios, Spitkovsky, Dimitry, Hescheler, Jürgen, Carmo, Helena, Arbo, Marcelo D., van de Water, Bob, Wink, Steven, Vinken, Mathieu, Rogiers, Vera, Escher, Sylvia, Hardy, Barry, Mitic, Dragana, Myatt, Glenn, Waldmann, Tanja, Mardinoglu, Adil, Damm, Georg, Seehofer, Daniel, Nüssler, Andreas, Weiss, Thomas S., Oberemm, Axel, Lampen, Alfons, Schaap, Mirjam M., Luijten, Mirjam, van Steeg, Harry, Thasler, Wolfgang E., Kleinjans, Jos C. S., Stierum, Rob H., Leist, Marcel, Rahnenführer, Jörg, and Hengstler, Jan G.

Published
2014
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20. PROTEOMIC ANALYSIS OF HEPATIC EFFECTS OF OKADAIC ACID IN HEPARG HUMAN LIVER CELLS.

Author

Wuerger, Leonie T. D., Birkholz, Greta, Oberemm, Axel, Sieg, Holger, and Braeuning, Albert

Subjects
LIVER cells, POISONS, SEAFOOD poisoning, ADIPOSE tissues, PROTEIN expression, HOMEOSTASIS, PROTEOMICS
Abstract

The marine biotoxin okadaic acid (OA) is produced by dinoflagellates and enters the human food chain by accumulating in the fatty tissue of filter-feeding shellfish. Consumption of highly contaminated shellfish can lead to diarrheic shellfish poisoning. However, apart from the acute effects in the intestine, OA can also provoke toxic effects in the liver, as it is able to pass the intestinal barrier into the blood stream. However, molecular details of OA-induced hepatotoxicity are still insufficiently characterized, and especially at the proteomic level data are scarce. In this study, we used human HepaRG liver cells and exposed them to non-cytotoxic OA concentrations for 24 hours. Global changes in protein expression were analyzed using 2-dimensional gel electrophoresis in combination with mass-spectrometric protein identification. The results constitute the first proteomic analysis of OA effects in human liver cells and indicate, amongst others, that OA affects the energy homeostasis, induces oxidative stress, and induces cytoskeletal changes. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes

Author

Schug, Markus, Stöber, Regina, Heise, Tanja, Mielke, Hans, Gundert-Remy, Ursula, Godoy, Patricio, Reif, Raymond, Blaszkewicz, Meinolf, Ellinger-Ziegelbauer, Heidrun, Ahr, Hans-Jürgen, Selinski, Silvia, Günther, Georgia, Marchan, Rosemarie, Blaszkewicz, Meinolf, Sachinidis, Agapios, Nüssler, Andreas, Oberemm, Axel, and Hengstler, Jan G.

Published
2013
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22. Biomarkers of effect as determined in human biomonitoring studies on hexavalent chromium and cadmium in the period 2008–2020

Author

Ventura, Célia, primary, Gomes, Bruno Costa, additional, Oberemm, Axel, additional, Louro, Henriqueta, additional, Huuskonen, Pasi, additional, Mustieles, Vicente, additional, Fernández, Mariana F., additional, Ndaw, Sophie, additional, Mengelers, Marcel, additional, Luijten, Mirjam, additional, Gundacker, Claudia, additional, and Silva, Maria João, additional

Published
2021
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34. Comparative proteomic analysis of silver nanoparticle effects in human liver and intestinal cells.

Author

Braeuning, Albert, Oberemm, Axel, Görte, Josephine, Böhmert, Linda, Juling, Sabine, and Lampen, Alfonso

Subjects
PROTEOMICS, SILVER nanoparticles, LIVER, FOOD additives, BIOINFORMATICS, CELL lines
Abstract

Abstract: Consumers are orally exposed to nanoparticulate or soluble species of the non‐essential element silver due to its use in food contact materials or as a food additive. Potential toxicity of silver nanoparticles has gained special scientific attention. A fraction of ingested ionic or particulate silver is taken up in the intestine and transported to the liver, where it may induce oxidative stress and elicit subsequent adverse responses. Here, we present a comprehensive analysis of global proteomic changes induced in human Hep G2 hepatocarcinoma cells by different concentrations of AgPURE silver nanoparticles or by corresponding concentrations of ionic silver. Bioinformatic analysis of proteomic data confirms and substantiates previous findings on silver‐induced alterations related to redox stress, mitochondrial dysfunction, intermediary metabolism, inflammatory responses, posttranslational protein modification and other cellular parameters. Similarities between the effects exerted by the two silver species are in line with the assumption that silver ions released from nanoparticles substantially contribute to their toxicity. Moreover, a comparative bioinformatic evaluation of proteomic effects in hepatic and intestinal cells exerted either by silver nanoparticles or bionic silver is presented. Our results show that, despite remarkable differences at the level of affected proteins in the different cell lines, highly similar biological consequences, corresponding to previous in vivo findings, can be deduced by applying appropriate bioinformatic data mining. [ABSTRACT FROM AUTHOR]

Published
2018
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39. Proteomic responses of human intestinal Caco-2 cells exposed to silver nanoparticles and ionic silver.

Author

Oberemm, Axel, Hansen, Ulf, Böhmert, Linda, Meckert, Christine, Braeuning, Albert, Thünemann, Andreas F., and Lampen, Alfonso

Subjects
PROTEOMICS, SILVER nanoparticles, GEL electrophoresis, MASS spectrometry, OXIDATIVE stress, CELL culture, PHYSIOLOGY
Abstract

Even although quite a number of studies have been performed so far to demonstrate nanoparticle-specific effects of substances in living systems, clear evidence of these effects is still under debate. The present study was designed as a comparative proteomic analysis of human intestinal cells exposed to a commercial silver nanoparticle reference material and ions from AgNO3. A two-dimensional gel electrophoresis/MALDI mass spectrometry (MS)-based proteomic analysis was conducted after 24-h incubation of differentiated Caco-2 cells with non-cytotoxic and low cytotoxic silver concentrations (2.5 and 25 µg ml−1 nanosilver, 0.5 and 5 µg ml−1 AgNO3). Out of an overall number of 316 protein spots differentially expressed at a fold change of ≥ 1.4 or ≤ −1.4 in all treatments, 169 proteins could be identified. In total, 231 spots were specifically deregulated in particle-treated groups compared with 41 spots, which were limited to AgNO3-treatments. Forty-four spots (14 %) were commonly deregulated by both types of treatment. A considerable fraction of the proteins differentially expressed after treatment with nanoparticles is related to protein folding, synthesis or modification of proteins as well as cellular assembly and organization. Overlays of networks obtained for particulate and ionic treatments showed matches, indicating common mechanisms of combined particle and ionic silver exposure and exclusive ionic silver treatment. However, proteomic responses of Caco-2 cells treated with higher concentrations of silver species also showed some differences, for example regarding proteins related to fatty acid and energy metabolism, suggesting an induction of also some different molecular mechanisms for particle exposure and ionic treatment. Copyright © 2015 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2016
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40. Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes

Author

Schug, Markus, primary, Stöber, Regina, additional, Heise, Tanja, additional, Mielke, Hans, additional, Gundert-Remy, Ursula, additional, Godoy, Patricio, additional, Reif, Raymond, additional, Blaszkewicz, Meinolf, additional, Ellinger-Ziegelbauer, Heidrun, additional, Ahr, Hans-Jürgen, additional, Selinski, Silvia, additional, Günther, Georgia, additional, Marchan, Rosemarie, additional, Sachinidis, Agapios, additional, Nüssler, Andreas, additional, Oberemm, Axel, additional, and Hengstler, Jan G., additional

Published
2012
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46. Differential signatures of protein expression in marmoset liver and thymus induced by single-dose TCDD treatment

Author

Oberemm, Axel, primary, Meckert, Christine, additional, Brandenburger, Linda, additional, Herzig, Andrea, additional, Lindner, Yvonne, additional, Kalenberg, Kareen, additional, Krause, Eberhard, additional, Ittrich, Carina, additional, Kopp-Schneider, Annette, additional, Stahlmann, Ralf, additional, Richter-Reichhelm, Hans-Bernhard, additional, and Gundert-Remy, Ursula, additional

Published
2005
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48. Establishing Causality between Pollution and Effects at Different Levels of Biological Organization: The VALIMAR Project

Author

Triebskorn, Rita, primary, Adam, Stefan, additional, Behrens, Anja, additional, Beier, Stefanie, additional, Böhmer, Jürgen, additional, Braunbeck, Thomas, additional, Casper, Heidi, additional, Dietze, Uwe, additional, Gernhöfer, Maike, additional, Honnen, Wolfgang, additional, Köhler, Heinz-R., additional, Körner, Wolfgang, additional, Konradt, Jens, additional, Lehmann, Reinhold, additional, Luckenbach, Till, additional, Oberemm, Axel, additional, Schwaiger, Julia, additional, Segner, Helmut, additional, Strmac, Marija, additional, Schüürmann, Gerrit, additional, Siligato, Simonetta, additional, and Traunspurger, Walter, additional

Published
2003
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