60 results on '"Obayashi N"'
Search Results
2. Report on Peace Education I in the 9th grade : Through war experiences(II:Teaching the General Human Studies aimed at Career Development)
- Author
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KAWATA, M., HARA, J., SHIGEMORI, H., OBAYASHI, N., and OKAMURA, A.
- Subjects
異文化理解 ,杉原千畝 ,フィールドワーク ,平和学習 ,被爆証言 ,広島 - Abstract
中学3年では国際理解と平和をテーマとし、前半は杉原千畝研究を軸に国際理解に重点をおき、後半は広島でのフィールドワークを中心に平和学習に取り組んだ。, 国立情報学研究所で電子化したコンテンツを使用している。
- Published
- 2008
3. Manabi no Mori Course : Guest Lecturer Series Collaborated with Nagoya University(V:Teaching the Advanced Science Project (ASP))
- Author
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ISHIKAWA, K., SUZUKI, K., TERAI, H., KATO, Y., OBAYASHI, N., SOGA, Y., KONDO, K., and OGUCHI, E.
- Subjects
先端的 ,大学連携 ,学びの杜 ,アドバンストサイエンスプロジェクト - Abstract
平成18年度より指定を受けたスーパーサイエンスハイスクールのプロジェクトの一環として、アドバンストサイエンスプロジェクト(ASP)を立ち上げた。発展的、先端的な内容を学びたい生徒のための大学教員による授業である。専門研究を担う名古屋大学の各研究科、教育研究を担う教育発達科学研究科、中等教育を担う附属学校の三位一体の教育実践・研究を行うことを目標としている。10回シリーズで本校の単位として認定される「学びの杜学術コース」と1回で完結する「学びの杜総合コース」がある。, 国立情報学研究所で電子化したコンテンツを使用している。
- Published
- 2008
4. A Report from Environmental Education II in the 10th Grade (II:Practice of General Human Studies)
- Author
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SAITO, A., KINOSHITA, M., OBAYASHI, N., TAKEUCHI, F., OKAMURA, A., and SATO, K.
- Subjects
フィールドワーク ,生き方 ,生命 ,キャリア形成 ,学び合い ,地球社会 ,環境 - Abstract
高校1年の総合人間科では、生命と環境につながる「個人テーマ」を持ち、フィールドワークをし、レポートにまとめ発表する。一年間の取り組みを通して、お互いに学び合うことで地球社会の様々な問題を考える。自覚的なキャリア形成の第一歩とする。, 国立情報学研究所で電子化したコンテンツを使用している。
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- 2006
5. A Report from Career Development Studies II in the 12th Grade (II. Practice of General Human Studies)
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Suzuki, K., Takeuchi, F., Terai, H., Obayashi, N., Fukutani, S., and Nakano, K.
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進路決定 ,満足感 ,研究テーマ ,一貫性 ,総合人間科 - Abstract
総合人間科において、高1から個人研究テーマに一貫性がある生徒は、高3時においてもより自分の夢や人生の目標に適った満足度の高い進路選択をすることを統計的に見た結果、その傾向が高いことがわかった。, 国立情報学研究所で電子化したコンテンツを使用している。
- Published
- 2005
6. A Report from Peace Education II in the 11th Grade (II. Practice of General Human Studies)
- Author
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Fujita, T., Mishima, T., Suzuki, Y., Kawata, M., Takeuchi, F., and Obayashi, N.
- Subjects
フィールドワーク ,感性 ,平和 ,共生 ,社会との関わり ,気づき ,市民 ,学び合い - Abstract
高校2年生では、沖縄をフィールドとして「平和」の問題を、沖縄戦、沖縄基地問題、沖縄の社会・経済、沖縄の歴史と教育、沖縄の生活様式、沖縄と世界という観点から学習し、世界の平和と共生の問題に自らどのように関わるかを考え、共に学ぶ機会を提供した。, 国立情報学研究所で電子化したコンテンツを使用している。
- Published
- 2004
7. A Report on Career Development Studies I in the 7th Grade(III : Practice of General Human Studies)
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KINOSHITA, M., OBAYASHI, N., HARA, J., YAMADA, T., and YAMADA, R.
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異学年との学び合い ,ともに学ぶ ,キヤリア形成 ,生き方を探る ,出会い - Abstract
平成14年度に新しい学習指導要領が幼稚園・小学校・中学校で導入され、全国一斉に「総合的な学習の時間」の取り組みが開始された。実際には、すでに多くの学校園において平成14年度以前の移行措置の期間に試行的な取り組みが行われてきている。平成14度に本校に入学してきた生徒たちの多くも、小学校時代に「総合的な学習の時間」の取り組みを行った経験を持っていた。主に集団(グループやクラス全体)で個別的なテーマに焦点を当てた小学校時代のトピック学習とは異なり、中学1年生では「生き方を探る」という大テーマのもと、キャリア形成につながるような「生き方を探る」学習を進めてきた。 2002年度の授業実践においては、プログラムの大まかな内容については例年の流れを継承しつつ、「ともに学ぶ」ことを重視する学年のテーマに沿った活動をすべく、同じ「生き方を探る」というテーマで総合人間科の学習を進める高校3年生の生徒を講師に迎え「生き方を探る講演会」を実施し、1年間の学習活動を締めくくった。同学年の仲間同士で学び合う活動を一歩広げ、他学年の生徒、それも高校生と「ともに学ぶ」ことによって、生徒たちに入口(中1)と出口(高3)が一本に結ばれた中高一貫カリキユラムの特質を意識させる試みとなった。, 国立情報学研究所で電子化したコンテンツを使用している。
- Published
- 2003
8. Tenth Annual Meeting of the European Association for the Study of Diabetes: Jerusalem, Israel, September 11–13, 1974
- Author
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Alberti, K. G. M. M., Iversen, J., Christensen, N. J., Andersson, A., Jarrousse, Claire, Andersson, Arne, Hellerström, Claes, Andreani, D., Tamburrano, G., Tamburrano, S., Gambardella, S., Ardill, Joy, Montgomery, D. A. D., Hadden, D. R., Assan, R., Attali, J. R., Selmi, A., Bourdillat, N., Soufflet, E., Girard, J. R., Bajaj, J. S., Chinna, G. S., Garg, S. K., Singh, Baldev, Balasse, E. O., Neef, M. A., Beischer, W., Melani, F., Keller, L., Hinz, M., Kroder, A., Maier, V., Pfeiffer, E. F., Bendayan, M., Sandborn, E., Rasio, E., Bensoussan, D., Levy-Toledano, S., Passa, P., Caen, J., Berger, M., Goodman, M. N., Hagg, S. A., Ruderman, N. B., Beyer, J., Cordes, U., Travniczek, H., Heider, W., Schöffling, K., Happ, J., Grimm, H., Pünchera, W., Althoff, P. H., Fröhlich, A., Bianco, A. R., Schwartz, R. H., Handwerger, B. S., Blackshear, P. J., Holloway, P. A. H., Williamson, D. H., Boquist, L., Hellman, Bo, Lernmark, Åke, Täljedabl, Inge-Bert, Bottermann, P., Schweigart, U., Zilker, Th., Hansen, W., Brachet, E., Rogister, C., Broer, Y., Freychet, P., Rosselin, G., Brunengraber, H., Vertongen, F., Boutry, M., Camu, F., Christacopoulos, P., Karamanos, B., Papadimitriou, P., Kardatos, Ch., Christensen, Niels Juel, Neubauer, Bent, Christophe, Jean, Winand, Jacques, Dehaye, Jean, Cuendet, G. S., Loten, E. G., Jeanrenaud, B., Davis, E., Yodaiken, Ralph E., Yanko, L., Herman, J. B., Garcia, S. Duran, Jarrousse, C., Ditzel, J., Daugaard, Niels Peters, Andersen, Haakon, Egeberg, J., Nerup, J., Andersen, O. O., Kromann, H., Bendixen, G., Poulsen, J. E., Eschwege, E., Falkmer, S., Emdin, S. O., Havu, N., Biuw, L. Winbladh, Sundby, F., Cutfield, J. F., Cutfield, S. M., Dodson, G. G., Peterson, J. D., Steiner, D. F., Fallucca, F., Menzinger, G., Iavicoli, M., Federspil, G., de Palo, C., Zago, E., Casara, D., Zaccaria, M., Scandellari, C., Felber, J. -P., Magnenat, G., Curchod, B., Pittet, Ph., Lytras, N., Müller-Hess, R., Geser, C. A., Jéquier, E., Flanagan, R. W. J., Buchanan, K. D., Murphy, R. F., Fölling, Ivar, Fromantin, M., Freyria, J., Bressac, F., Geisthövel, W., Niedergerke, U., Morgner, K. D., Willms, B., Mitzkat, H. J., Gey, K. F., Bühler, E., Sommer, P., Gey, K. F., Georgi, H., Sommer, P., Lengsfeld, H., Ghiea, D., Costiner, E., Simionescu, L., Oprescu, M., Grill, V., Cerasi, E., Gundersen, H. J. G., Gutman, A., Adler, J., Bar-Or, D., Gutzeit, A., Cerasi, E., Guy-Grand, B., Bigorie, B., Gylfe, Erik, Idahl, Lars-Åke, Hamosh, Margit, Hamosh, Paul, Hart, Adrian, Cohen, H., Thorp, J. M., Hedeskov, C. J., Capito, K., Forruby, B., Henquin, J. C., Lambert, A. B., Lambert, A. E., Henquin, J. C., Hepp, K. D., Renner, R., Häring, H. U., Mehnert, H., Kemmler, W., Löffler, G., Mehnert, H., Herchuelz, A., Mahy, M., Herrera, Emilip, Garcia-Rafanell, J., Morell, J., Heuclin, Ch., Attali, J. R., Girard, J. R., Assan, R., Hicks, B. H., Taylor, C. I., Vij, S. K., Pek, S., Knopf, R. F., Floyd, Jr., J. C., Fajans, S. S., Hockaday, T. D. R., Hockaday, J. M., Mann, J. I., Turner, R. C., Hockaday, T. D. R., Honour, A. J., Ikeda, Y., Saito, S., Matsuura, Y., Obayashi, N., Morimoto, Y., Sano, T., Abe, M., Jacouot, R., Felix, J. M., Legrele, C., Sutter-Dub, M. -Th., Sutter, B. Ch. J., Kammerer, L., Fehér, J., Lévai, J., Dénes, R., Stützel, M., Balázsi, I., Láng, I., Littmann, L., Karakash, C., Assimacopoulos, F., Katsilambros, N., Papadopoulos, G., Varonos, D., Daikos, G., Keen, H., Jarrett, R. J., Fuller, J. H., Kiesselbach, N. H. K., Puls, W., Keup, U., Kikkawa, Ryuichi, Duvillard, D., Ravazzola, M., Stauffacher, W., Köbberling, J., Kattermann, R., Kobberling, J., Creutzfeldt, W., Kohner, Eva M., Hamilton, A. M., Joplin, G. F., Blach, R. K., Fraser, T. R., Kolb, H. J., Weiss, L., Wieland, O. H., Korn, A., Waldhäusl, W., Bonelli, J., Magometsohnigg, D., Hitzenberger, G., Kramp, Robert C., Kremer, G. J., Atzpodien, W., Schnellbacher, B., Krug, B., Mialhe, P., Gross, R., Landgraf, R., Landgraf-Leurs, M., Klingenburg, M., Melamed, I., Hörl, R., Jun, István Láng, Littmann, László, Stützel, Mária, Balázsi, Imre, Langslow, Derek R., Buchanan, Keith D., Freeman, Barry M., Berezin, Meir, Mincu, I., Dumitrescu, C., Ionescu-Tirgoviste, C., Mihalache, N., Boboia, D., Stanescu, J., Ghise-Beer, E., Georgescu, St., Bruckner, I., Popa, I., Muggeo, M., Tiengo, A., Padovan, D., Molinari, M., Müller, Walter A., and Sharp, Geoffrey W. G.
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- 1974
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9. P-099: Single center experience with infliximab in Japanese children with ulcerative colitis
- Author
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Shimizu, H., primary, Yanagi, T., additional, Minowa, K., additional, Obayashi, N., additional, Hosoi, K., additional, and Arai, K., additional
- Published
- 2014
- Full Text
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10. アドバンスト・サイエンス・プロジェクト(ASP)学びの杜(V アドバンスト・サイエンス・プロジェクト(ASP)の取り組み)
- Author
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石川 久美, ISHIKAWA K., 鈴木 克彦, SUZUKI K., 寺井 一, TERAI H., 加藤 容子, KATO Y., 大林 直美, OBAYASHI N., 曽我 雄司, SOGA Y., 近藤 和雅, KONDO K., 大口 悦子, OGUCHI E., 石川 久美, ISHIKAWA K., 鈴木 克彦, SUZUKI K., 寺井 一, TERAI H., 加藤 容子, KATO Y., 大林 直美, OBAYASHI N., 曽我 雄司, SOGA Y., 近藤 和雅, KONDO K., 大口 悦子, and OGUCHI E.
- Abstract
平成18年度より指定を受けたスーパーサイエンスハイスクールのプロジェクトの一環として、アドバンストサイエンスプロジェクト(ASP)を立ち上げた。発展的、先端的な内容を学びたい生徒のための大学教員による授業である。専門研究を担う名古屋大学の各研究科、教育研究を担う教育発達科学研究科、中等教育を担う附属学校の三位一体の教育実践・研究を行うことを目標としている。10回シリーズで本校の単位として認定される「学びの杜学術コース」と1回で完結する「学びの杜総合コース」がある。, 国立情報学研究所で電子化したコンテンツを使用している。
- Published
- 2008
11. 中学3年生:国際理解と平和I : 戦争体験から(II. キャリア形成を軸とした総合人間科の取り組み)
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川田 基生, KAWATA M., 原 順子, HARA J., 薫森 英夫, SHIGEMORI H., 大林 直美, OBAYASHI N., 岡村 明, OKAMURA A., 川田 基生, KAWATA M., 原 順子, HARA J., 薫森 英夫, SHIGEMORI H., 大林 直美, OBAYASHI N., 岡村 明, and OKAMURA A.
- Abstract
中学3年では国際理解と平和をテーマとし、前半は杉原千畝研究を軸に国際理解に重点をおき、後半は広島でのフィールドワークを中心に平和学習に取り組んだ。, 国立情報学研究所で電子化したコンテンツを使用している。
- Published
- 2008
12. 3.A Report from ASP Group (VI.Interim Reports from Intramural Research Groups)
- Author
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ISHIKAWA, K., KONDO, K., SUZUKI, K., TERAI, H., OBAYASHI, N., KATO, Y., SOGA, Y., and OGUCHI, E.
- Abstract
国立情報学研究所で電子化したコンテンツを使用している。, 本文に記載されている著者のうち「大村直美」は「大林直美」が正しいため,本メタデータでは正しく表示した。
- Published
- 2006
13. Crystal structure of the N-terminal RecA-like domain of a DEAD-box RNA helicase, the -like gene B protein
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KURIMOTO, K, primary, MUTO, Y, additional, OBAYASHI, N, additional, TERADA, T, additional, SHIROUZU, M, additional, YABUKI, T, additional, AOKI, M, additional, SEKI, E, additional, MATSUDA, T, additional, and KIGAWA, T, additional
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- 2005
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14. Role of endothelium-derived nitric oxide and adenosine in functional myocardial hyperemia
- Author
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Maekawa, K., primary, Saito, D., additional, Obayashi, N., additional, Uchida, S., additional, and Haraoka, S., additional
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- 1994
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15. Quantitative characterization and potential function of membrane Fas/APO-1 (CD95) receptors on leukaemic cells from chronic B and T lymphoid leukaemias
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amihira, S himeru K, amada, Y asuaki Y, irakata, Y oichi H, suruda, K azuto T, ugahara, K azuyuki S, omonaga, M asao T, aeda, T akahiro M, sukasaki, K unihiro T, togami, S unao A, and obayashi, N obuyuki K
- Abstract
The expression and function of the Fas-receptor (Fas-R) were examined in chronic lymphocytic leukaemia (CLL), hairy cell leukaemia-variant (HCL-v) and adult T-cell leukaemia (ATL). The expression of Fas-R in freshly isolated leukaemic cells was qualitatively and quantitatively different between each disease; faint in B-CLL, moderate in HCL-v and strong in ATL. Both full-length and alternatively spliced truncated forms of Fas mRNA were detected even in CLL B cells with faint to negative Fas-R, and Fas mRNA was also shown to be capable of increasing in vitro expression, i.e. the message was functional. In contrast, Fas-R expression on ATL cells was heterogenous and usually intense with a mean density approximately 3-fold higher than that of normal T cells. Fas-R was confirmed to have the potential function for anti-Fas monoclonal antibody-mediated cell death in vitro in Fas-R+ ATL cells. The expression level of Fas-R on the cells was higher in chronic than acute ATL (10360 v 6260 antibody-binding capacity per cell, mFasABC; P < 0.05) and was inversely correlated with serum LDH activity, suggesting that the strong Fas-R accounts for the slow progression of chronic ATL and the negative Fas-R protects from Fas-mediated cell death. These results show that Fas-R expression on leukaemic cells is valuable in their characterization and perhaps their function, and may contribute to the progression and immune evasion of malignant clones.
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- 1997
16. Relationship of oral bacterial number with medical hospitalization costs in analysis of Diagnosis Procedure Combination database from single institution in Japan.
- Author
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Nishi H, Kajiya M, Ohta K, Shigeishi H, Obayashi T, Munenaga S, Obayashi N, Yoshioka Y, Konishi M, Naruse T, Matsumoto A, Odo A, Kitagawa M, Ando T, Shintani T, Tokikazu T, Ino N, Mihara N, Kakimoto N, Tsuga K, Tanimoto K, Ohge H, Kurihara H, and Kawaguchi H
- Subjects
- Humans, Female, Male, Japan epidemiology, Aged, Middle Aged, Mouth microbiology, Databases, Factual, Aged, 80 and over, Hospital Costs, Bacterial Load, Bacteria isolation & purification, Bacteria classification, Health Care Costs, Adult, Length of Stay economics, Hospitalization economics
- Abstract
Oral bacteria are known to be associated with perioperative complications during hospitalization. However, no presented reports have clarified the relationship of oral bacterial number with medical costs for inpatients. The Diagnosis Procedure Combination (DPC) database system used in Japan provides clinical information regarding acute hospital patients. The present study was conducted to determine the association of oral bacterial numbers in individual patients treated at a single institution with length of hospital stay and medical costs using DPC data. A total of 2369 patients referred by the medical department to the dental department at Hiroshima University Hospital were divided into the low (n = 2060) and high (n = 309) oral bacterial number groups. Length of hospital stay and medical costs were compared between the groups, as well as the associations of number of oral bacteria with Charlson comorbidity index (CCI)-related diseases in regard to mortality and disease severity. There was no significant difference in hospital stay length between the low (24.3 ± 24.2 days) and high (22.8 ± 20.1 days) oral bacterial number groups. On the other hand, the daily hospital medical cost in the high group was significantly greater (US$1456.2 ± 1505.7 vs. US$1185.7 ± 1128.6, P < 0.001). Additionally, there was no significant difference in CCI score between the groups, whereas the daily hospital medical costs for patients in the high group treated for cardiovascular disease or malignant tumors were greater than in the low number group (P < 0.05). Multivariate regression analysis was also performed, which showed that oral bacterial number, age, gender, BMI, cardiovascular disease, diabetes, malignant tumor, and hospital stay length were independently associated with daily hospitalization costs. Monitoring and oral care treatment to lower the number of oral bacteria in patients affected by cardiovascular disease or cancer may contribute to reduce hospitalization costs., (© 2024. The Author(s).)
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- 2024
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17. Characteristics of dental materials in the oral cavities of Asian individuals between their 20s and early 40s living temporarily in Japan based on 38 case studies.
- Author
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Oka H, Obayashi N, Yoshikawa M, and Kakimoto N
- Subjects
- Humans, Japan, Adult, Young Adult, Male, Female, Asian People, Mouth, Dental Materials
- Abstract
Characterization of materials used in dental restorations and fixed prostheses is useful for personal identification. This study investigated the dental treatment trends and use of metal materials among non-Japanese Asian temporary residents and Japanese individuals aged from 20 to 40 years living in a city in Japan. Analysis of 38 participants from different Asian countries showed prominent use of resin fillings, with metal element analysis revealing nickel-chromium (Ni-Cr) or cobalt-chromium (Co-Cr) alloys. Among five Japanese participants of the same age with dental metal treatment scars, resin fillings and silver-palladium-copper-gold (Ag-Pd-Cu-Au) or silver-indium (Ag-In) alloys were observed. This study suggested some regional differences in dental material choices in Asia.
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- 2024
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18. Skin Symptoms That Appeared after Fixation with a Titanium Plate in a Jaw Deformity Patient Suffering from Palmoplantar Pustulosis: A Case Report.
- Author
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Obayashi F, Koizumi K, Ito N, Obayashi N, Shintani T, Kajiya M, and Yanamoto S
- Abstract
Palmoplantar pustulosis (PPP) is a stubborn skin disease involving repeated aseptic small pustules on the palms and soles of the feet, which is triggered and exacerbated by metals and dental focal infections. There are few reports of an exacerbation of PPP symptoms after orthognathic surgery. The patient is a 40-year-old female who consulted an orthodontist at our hospital, complaining of a protruding maxilla and malocclusion. Under the diagnosis of skeletal prognathism, she underwent surgery for jaw deformity. Although no allergic symptoms were observed during the orthodontic treatment prior to surgery, postoperative scaling on the palms and soles of her feet worsened, and itching was observed on the skin, especially on the titanium plate used to secure the bone fragments. Under the diagnosis of metal allergy, treatment with steroids and vitamin D ointment failed to improve the condition, so surgery was performed to replace the metal plate with a non-metallic absorbable plate in the third postoperative month. Afterwards, the pruritus resolved, and erythema and scale on the palms and soles nearly disappeared. In the present case, though, oral bacterial infection, a past history of smoking, and stress from surgery were also considered to be possible causes of PPP exacerbation, and we concluded that one of the causes of PPP exacerbation was metal allergy from the plates or screws used to fix the bone fragments.
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- 2023
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19. Non-contact robotic manipulation of floating objects: exploiting emergent limit cycles.
- Author
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Jacquart S, Obayashi N, and Hughes J
- Abstract
The study of non-contact manipulation in water, and the ability to robotically control floating objects has gained recent attention due to wide-ranging potential applications, including the analysis of plastic pollution in the oceans and the optimization of procedures in food processing plants. However, modeling floating object movements can be complex, as their trajectories are influenced by various factors such as the object's shape, size, mass, and the magnitude, frequency, and patterns of water waves. This study proposes an experimental investigation into the emergence ofrobotically controlled limit cycles in the movement of floating objects within a closed environment. The objects' movements are driven by robot fins, and the experiment plan set up involves the use of up to four fins and variable motor parameters. By combining energy quantification of the system with an open-loop pattern generation, it is possible to demonstrate all main water-object interactions within the enclosed environment. A study using dynamic time warping around floating patterns gives insights on possible further studies., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Jacquart, Obayashi and Hughes.)
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- 2023
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20. Taste-taste associations in chemotherapy-induced subjective taste alterations: findings from a questionnaire survey in an outpatient clinic.
- Author
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Obayashi N, Sugita M, Shintani T, Nishi H, Ando T, Kajiya M, Kawaguchi H, Ohge H, and Naito M
- Subjects
- Surveys and Questionnaires, Cross-Sectional Studies, Humans, Male, Female, Adult, Middle Aged, Aged, Aged, 80 and over, Dysgeusia chemically induced, Taste Perception, Neoplasms drug therapy, Antineoplastic Agents adverse effects
- Abstract
Purpose: Chemotherapy-induced taste alteration is a side effect that can result in malnutrition and reduced quality of life in cancer patients. However, the underlying causes of this phenomenon remain unclear, and evidence-based treatments have not been established. This study focused on patients' subjective symptoms of taste alterations aimed to explore how the sensitivity to basic tastes changes due to anticancer agents and how alterations in one taste perception are associated with changes in other tastes during chemotherapy., Methods: A cross-sectional questionnaire-based interview survey was conducted on 215 patients undergoing chemotherapy. The subjective sensitivity to each basic taste was assessed using a visual analog scale, and the incidence of taste alterations due to different chemotherapy regimens was calculated. Multivariate logistic regression analysis was performed to determine whether there were associations between changes in one taste sensitivity and changes in other taste sensitivities., Results: Approximately half (49.5%) of the patients experienced chemotherapy-induced taste alterations. An analysis of subjective changes in basic tastes revealed that the salt and umami taste systems were more sensitive to chemotherapy than other taste systems. Patients with altered sensitivity to sweet taste were significantly more likely to report altered sensitivity to salt, bitter, and sour tastes. Moreover, umami-salt and bitter-sour taste sensitivities were significantly related to each other., Conclusion: This study suggests that changes in subjective sensitivities to one basic taste during chemotherapy may be accompanied by changes in other tastes in specific combinations. Considering taste associations in dietary guidance may help improve the nutritional status of cancer patients experiencing taste alterations due to chemotherapy., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2023
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21. Resting saliva volume as a risk factor for hypogeusia: A retrospective study.
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Shintani T, Naito M, Obayashi N, Ando T, Kawaguchi H, Yanamoto S, Kajiya M, and Sugita M
- Subjects
- Humans, Saliva, Retrospective Studies, Taste, Risk Factors, Zinc, Taste Threshold, Ageusia etiology, Candidiasis, Oral complications
- Abstract
Objectives: The causes of hypogeusia include zinc deficiency, systemic illness, and consumption of drugs. Notably, patients with oral cavity diseases such as oral candidiasis and salivary gland hypofunction may present with risk factors that remain unreported. Hence, this study aimed to investigate the relationship between age, sex, smoking status, serum zinc concentration, oral candidiasis, saliva volume, and taste function in patients with hypogeusia., Subjects and Methods: Overall, 335 participants who complained of taste abnormalities underwent a taste test. Based on the recognition threshold value, the participants were classified as normal individuals (recognition threshold of 1 and 2) and patients with hypogeusia (recognition threshold of ≥3). The clinical characteristics, including resting saliva volume (RSV) and stimulated saliva volume (SSV), were compared, and a multivariate logistic regression analysis focusing on RSV was performed., Results: Patients with hypogeusia had a lower RSV than normal individuals for all tastes, but not for SSV. Based on the results of regression analysis, RSV was identified as an independent predictor of hypogeusia for salty and bitter tastes. Moreover, the proportion of patients with decreased RSV increased as the number of taste qualities exceeding the reference recognition threshold increased. Furthermore, a decrease in RSV was associated with an increase in the recognition threshold for salty and bitter tastes., Conclusions: Based on the results of the present study, moisturizing the oral cavity may be useful against hypogeusia., Competing Interests: Declaration of Competing Interest Authors have no relevant competing intereststo declare., (Copyright © 2023. Published by Elsevier Inc.)
- Published
- 2023
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22. A case report of allergic reaction with acute facial swelling: a rare complication of dental acrylic resin.
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Obayashi N, Shintani T, Kamegashira A, Oka H, Ando T, Miyata R, Kawaguchi H, and Kajiya M
- Subjects
- Female, Humans, Middle Aged, Methacrylates adverse effects, Inflammation, Acrylic Resins adverse effects, Hypersensitivity
- Abstract
Resin components, such as methyl methacrylate (MMA) can cause allergic contact dermatitis (ACD). Allergic reactions to resin are usually delayed. Only a few studies have reported dental resin allergy with acute symptoms. Here, a case of ACD with acute facial swelling after dental treatment using resin material is reported. A 55-year-old woman with a history of periungual inflammation when using gel nail polish had repeated episodes of facial swelling after dental treatment with resin material. The resin temporary crown was removed, and symptoms were alleviated with antihistamines and corticosteroids. With the suspicion of resin allergy, skin tests were performed. Patch testing revealed positive reactions to self-adhesive resin cement (primer and polymerized), self-curing acrylic resin (liquid and polymerized), 2-hydroxyethyl methacrylate (2-HEMA), and ethylene glycol dimethacrylate (EGDMA), whereas the prick test was negative for all allergens. Complement C4 and C1 inhibitor activity were reference values in the tests for hereditary angioedema. Based on these findings, the patient was diagnosed with ACD to 2-HEMA and EGDMA. Since diagnosis, no similar symptoms have been observed in subsequent dental treatment with non-resin materials. The use of dental resin materials may cause ACD with an acute reaction. This report alerts dentists who routinely use resin materials.
- Published
- 2023
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23. Effect of irinotecan administration on amiloride-sensitive sodium taste responses in mice.
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Obayashi N, Sakayori N, Kawaguchi H, and Sugita M
- Subjects
- Mice, Animals, Sodium metabolism, Sodium pharmacology, Taste, Irinotecan metabolism, Irinotecan pharmacology, Dysgeusia, Amiloride pharmacology, Amiloride metabolism, Taste Buds
- Abstract
Taste alteration is a frequently reported side effect in patients receiving the chemotherapeutic agent, irinotecan. However, the way in which irinotecan causes taste disturbance and the type of taste impairment that is affected remain elusive. Here, we used the two-bottle preference test to characterize behavioral taste responses and employed immunohistochemical analyses to clarify the types and mechanisms of taste alteration induced, in mice, by irinotecan administration. Irinotecan administration resulted in a reduced intake of sodium taste solution but had no effect on sweet taste responses, as determined in the two-bottle preference test. In the presence of amiloride, which inhibits the function of the epithelial sodium channel (ENaC) in the periphery, the intake of sodium taste solution was comparable between the irinotecan-treated and control groups. Immunohistochemical analyses revealed that α-ENaC immunoreactivity detected in taste bud cells decreased slowly after irinotecan administration, and that administration of irinotecan had little effect on the number of cells expressing the cellular proliferation marker, Ki67, within or around taste buds. Our results imply that irinotecan administration may be responsible for altered behavioral sodium taste responses originating from ENaC function in the periphery, while being accompanied by the reduction of α-ENaC expression at the apical membrane of taste receptor cells without disturbing taste cell renewal., (© 2023 Scandinavian Division of the International Association for Dental Research. Published by John Wiley & Sons Ltd.)
- Published
- 2023
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24. Robotic automation and unsupervised cluster assisted modeling for solving the forward and reverse design problem of paper airplanes.
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Obayashi N, Junge K, Ilić S, and Hughes J
- Abstract
Although often regarded a childhood toy, the design of paper airplanes is subtly complex. The design space and mapping from geometry to distance flown is highly nonlinear and probabilistic where a single airplane design exhibits a multitude of trajectory forms and flight distances. This makes optimization and understanding of their behavior challenging for humans. By understanding the behavior of paper airplanes and predicting flight behavior, there is a potential to improve the design of aerial vehicles that operate at low Reynolds numbers. By developing a robotic system that can fabricate, test, analyze, and model the flight behavior in an unsupervised fashion, a wide design space can be reliably characterized. We find there are discrete behavioral groups that result in different trajectories: nose dive, glide, and recovery glide. Informed by this characterization we propose a method of using Gaussian mixture models to extract the clusters of the design space that map to these different behaviors. This allows us to solve both the forward and reverse design problem for paper airplanes, and also to perform efficient optimization of the geometry for a given target flight distance., (© 2023. The Author(s).)
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- 2023
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25. Enhanced polarotaxis can explain water-entry behaviour of mantids infected with nematomorph parasites.
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Obayashi N, Iwatani Y, Sakura M, Tamotsu S, Chiu MC, and Sato T
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- Animals, Mantodea physiology, Photic Stimulation, Host-Parasite Interactions physiology, Light, Mantodea parasitology, Mantodea radiation effects, Parasites physiology, Phototaxis radiation effects, Water
- Abstract
A wide range of parasites manipulate the behaviours of their hosts in order to complete their life cycle
1 . Alteration of phototaxis is thought to be involved in host manipulation in many cases2 , 3 . However, very little is known about what features of the light (intensity, spectrum, polarization) alter behaviour. Here we report that arboreal mantids (Hierodula patellifera) infected by nematomorph parasites (Chordodes sp.) are attracted to horizontally polarized light, which could induce the mantids to enter water, where the parasites can then emerge and reproduce. In a two-choice test, infected mantids were attracted to horizontally but not vertically polarized light. Uninfected mantids were not attracted to either. In a field experiment, 14 infected mantids entered a deep pool, where the water surface strongly reflected horizontally polarized light. By contrast, only two mantids entered a shallow pool, where the surface reflection had higher light intensity but weaker polarization. To our knowledge, this is the first study demonstrating that a manipulative parasite can take advantage of its hosts' ability to perceive polarized light stimuli to alter host behaviour. VIDEO ABSTRACT., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2021 Elsevier Inc. All rights reserved.)- Published
- 2021
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26. Host response genes associated with nodular gastritis in Helicobacter pylori infection.
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Ikuse T, Ohtsuka Y, Obayashi N, Jimbo K, Aoyagi Y, Kudo T, Asaoka D, Hojo M, Nagahara A, Watanabe S, Blanchard TG, Czinn SJ, and Shimizu T
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Female, Gastritis complications, Genetic Predisposition to Disease, Helicobacter pylori, Humans, Male, Middle Aged, Oligonucleotide Array Sequence Analysis methods, Gastritis genetics, Helicobacter Infections complications, Stomach pathology
- Abstract
Background: Chronic Helicobacter pylori infection in children induces lymphoid hyperplasia called nodular gastritis (NG) at the antral gastric mucosa. The aim of this study was to evaluate genes in gastric biopsy on microarray analysis, to identify molecules associated with NG on comparison with NG-negative pediatric corpus tissue and with H. pylori-infected adult tissue with atrophic gastritis (AG)., Methods: Eight pediatric and six adult H. pylori-infected patients, as well as six pediatric and six adult uninfected patients were evaluated. All infected adults had AG. NG was observed in the antrum of all eight pediatric patients and in the corpus of three patients. Adult and uninfected patients were free of NG; that is, only pediatric H. pylori-infected patients had NG. Total RNA was purified from gastric biopsy, and microarray analysis was performed to compare gene expression between groups. The three infected children with NG in both the antrum and corpus were excluded from analysis of corpus samples., Results: The number of genes significantly up- or downregulated (fold change >3, P < 0.01) compared with uninfected controls varied widely: 72 in pediatric antrum, 45 in pediatric corpus, 103 in adult antrum and 71 in adult corpus. Nineteen genes had significantly altered expression in the antrum of NG tissue compared with NG-negative pediatric corpus tissue and adult AG tissue. The CD20 B-cell specific differentiation antigen had the most pronounced increase. Previously described regulators of NG development were not predominantly upregulated in the NG mucosa., Conclusions: CD20 overexpression may play an important role in lymphoid follicle enlargement and NG., (© 2018 Japan Pediatric Society.)
- Published
- 2018
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27. Comparison of Gene Expression Between Pediatric and Adult Gastric Mucosa with Helicobacter pylori Infection.
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Obayashi N, Ohtsuka Y, Hosoi K, Ikuse T, Jimbo K, Aoyagi Y, Fujii T, Kudo T, Asaoka D, Hojo M, Nagahara A, Watanabe S, and Shimizu T
- Subjects
- Adolescent, Adult, Biopsy, Child, Child, Preschool, Endoscopy, Gastrointestinal, Female, Humans, Immunohistochemistry, Japan, Male, Microarray Analysis, Middle Aged, Real-Time Polymerase Chain Reaction, Gastric Mucosa pathology, Gene Expression Profiling, Helicobacter Infections pathology
- Abstract
Background: Although Helicobacter pylori infection among adults is a major risk factor for the development of gastric cancer and initial infection with H. pylori may occur before 5 years of age, the direct effects of H. pylori infection since childhood on gastric mucosa are unknown. The aim of this study was to evaluate gene expression in the H. pylori-infected gastric mucosa of children., Methods: Gastric mucosal samples were obtained from 24 patients (12 adults and 12 children) who had undergone endoscopic evaluation of chronic abdominal complaints and were examined by the adult and pediatric gastroenterologists at Juntendo University Hospital. Six adult and pediatric patients with and six without H. pylori infection were enrolled. Their gastric mucosal samples obtained from the antrum and corpus were used for microarray, real-time polymerase chain reaction, and immunohistochemical analyses to examine the expression of inflammatory carcinogenic molecules., Results: The expression of inflammatory molecules was upregulated in the H. pylori-infected gastric mucosa from both adults and children. The expression of olfactomedin-4 was only upregulated in adult patients, while that of pim-2, regenerating islet-derived 3 alpha, lipocalin-2, and C-X-C motif chemokine ligand 13 was equally upregulated in the infected gastric mucosa of both adults and children., Conclusions: Because several carcinogenic molecules are upregulated in H. pylori-infected gastric mucosa even in children, early eradication therapy from childhood may be beneficial to decrease the incidence of gastric cancer. Although increased expression of olfactomedin-4 can be important in suppressing gastric cancer in adults, the increase was not detected in children., (© 2015 John Wiley & Sons Ltd.)
- Published
- 2016
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28. Leopard Skin-Like Colonic Mucosa: A Novel Endoscopic Finding of Chronic Granulomatous Disease-Associated Colitis.
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Obayashi N, Arai K, Nakano N, Mizukami T, Kawai T, Yamamoto S, Shimizu H, Nunoi H, Shimizu T, Tang J, and Onodera M
- Subjects
- Abdominal Pain etiology, Abdominal Pain pathology, Adolescent, Child, Child, Preschool, Colonoscopy, Crohn Disease complications, Crohn Disease surgery, Diarrhea etiology, Diarrhea pathology, Gastrointestinal Hemorrhage etiology, Gastrointestinal Hemorrhage pathology, Granulomatous Disease, Chronic complications, Granulomatous Disease, Chronic surgery, Humans, Macrophages pathology, Male, Retrospective Studies, Young Adult, Colon pathology, Crohn Disease pathology, Granulomatous Disease, Chronic pathology, Intestinal Mucosa pathology, Pigmentation
- Abstract
Background: Chronic granulomatous disease (CGD) is a rare inherited disorder in which phagocytes are unable to eradicate pathogens because of a deficit of nicotinamide adenine dinucleotide phosphate oxidase. Among CGD patients, ∼ 30% to 50% develop severe gastrointestinal tract symptoms. Although characteristic histologic findings of CGD-associated colitis have been reported, information on endoscopic features remained vague., Methods: A total of 8 male patients with CGD (ages 2-23 years) from 2 Japanese institutions underwent colonoscopy for the evaluation of their fever, diarrhea, bloody stool, and abdominal pain. The endoscopic and histologic findings were retrospectively reviewed., Results: The endoscopic findings of CGD-associated colitis appeared varied. Notably, brownish dots over a yellowish edematous mucosa were observed in 3 of the 8 patients. Prominent pigment-laden macrophages were noted histologically on the mucosa., Conclusions: Although nonspecific endoscopic findings of CGD-associated colitis have been reported before, our observation of brownish dots spread across a yellowish edematous mucosa, termed "leopard sign," could be a unique feature of this condition.
- Published
- 2016
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29. Management of tacrolimus-associated food allergy after liver transplantation.
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Obayashi N, Suzuki M, Yokokura T, Naritaka N, Nakano S, Ohtsuka Y, Sugo H, Kawasaki S, and Shimizu T
- Subjects
- Enzyme Inhibitors therapeutic use, Female, Food Hypersensitivity drug therapy, Humans, Immunosuppressive Agents adverse effects, Immunosuppressive Agents therapeutic use, Infant, Tacrolimus therapeutic use, Cyclosporine therapeutic use, Food Hypersensitivity etiology, Graft Rejection prevention & control, Liver Cirrhosis surgery, Liver Transplantation adverse effects, Tacrolimus adverse effects
- Abstract
Increasingly, food allergy associated with tacrolimus after pediatric living-donor liver transplantation (LT) has been reported. Tacrolimus prevents the activation of T cells by blocking calcineurin, thus producing an immunosuppressive effect, but tacrolimus induces an imbalance in T-helper type 1 (Th1) and Th2 cells in the food allergy process. This report describes a case of tacrolimus-associated food allergy after pediatric living-donor LT. The patient was a 7-year-old Japanese girl who had undergone living-donor LT at 12 months of age, and whom we first saw in the clinic at age 18 months. She received immunosuppressive therapy by tacrolimus after transplantation. Atopic dermatitis developed in post-transplant month 18. Stridor, facial edema, lip swelling, and skin erythema after consuming tempura udon containing wheat occurred in post-transplant month 39, and she was subsequently diagnosed with anaphylactic shock. Eosinophilic leukocyte and serum immunoglobulin (Ig)E increased, and specific IgE was positive for some food allergens. Pharmacotherapy was therefore changed from tacrolimus to cyclosporine A, after which eosinophilic leukocyte and serum IgE decreased and atopic dermatitis improved., (© 2015 Japan Pediatric Society.)
- Published
- 2015
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30. Validation of predictive equations for resting energy expenditure in Japanese pediatric Crohn's disease patients: preliminary study.
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Arai K, Funayama R, Takahashi M, Sakai R, Shimizu H, Obayashi N, and Matsui A
- Subjects
- Adolescent, Asian People, Body Composition, Calorimetry, Indirect methods, Child, Female, Humans, Japan, Male, Predictive Value of Tests, Regression Analysis, Crohn Disease physiopathology, Energy Metabolism physiology
- Abstract
Background: Predictive equations are often used to estimate resting energy expenditure (REE). Determining the appropriate equation for different patient types, however, remains inconclusive, as in the case of Japanese children with Crohn's disease (CD). The aim of this study was to identify an appropriate predictive equation for measuring REE in Japanese children with CD., Methods: Twelve Japanese children with CD managed at the National Center for Child Health and Development in Tokyo, Japan, were studied. REE (kcal/day) was measured using indirect calorimetry. The predictive equations used were the Japanese Dietary Reference Intakes (2010), the Schofield equation, the Food and Agriculture Organization/World Health Organization/United Nations University (FAO/WHO/UNU) equation and the Cunningham equation. Difference between predicted and measured REE was analyzed on Bland-Altman plot., Results: Japanese Dietary Reference Intakes (2010) had the smallest difference between predicted and measured REE. Weight was the primary predictor of REE on multiple regression analysis. As well, Japanese Dietary Reference Intakes (2010) had the highest ratio of weight to predicted REE (98.5%)., Conclusions: Of the four equations, Japanese Dietary Reference Intakes (2010) appeared to be the most practical and accurate predictive equation for REE in Japanese children with CD., (© 2014 Japan Pediatric Society.)
- Published
- 2015
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31. Romiplostim treatment allows for platelet transfusion-free liver transplantation in pediatric thrombocytopenic patient with primary sclerosing cholangitis.
- Author
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Minowa K, Arai K, Kasahara M, Sakamoto S, Shimizu H, Nakano N, Ito R, Obayashi N, Nakazawa A, and Ishiguro A
- Subjects
- Child, Preschool, Female, Humans, Immunosuppressive Agents therapeutic use, Platelet Transfusion, Cholangitis, Sclerosing surgery, Liver Transplantation, Receptors, Fc therapeutic use, Recombinant Fusion Proteins therapeutic use, Thrombocytopenia surgery, Thrombopoietin therapeutic use
- Abstract
Thrombocytopenia is a major risk factor for cirrhotic liver disease. Patients with thrombocytopenia may have esophageal or gastric varices secondary to portal hypertension, leading to variceal bleeding which exposes the liver to further damage. Here, we present a female pediatric patient with PSC and CD, whose progressive thrombocytopenia was successfully controlled by romiplostim, a TPO receptor agonist. The patient developed bloody diarrhea at four yr of age, and was subsequently diagnosed with PSC and CD when seven yr old. While CD was well-controlled by immunomodulators, the patient's thrombocytopenia gradually progressed resulting in petechiae (platelet count of 11 × 10(9) /L) when she was 10 yr and four months old. She responded poorly to immunoglobulin and corticosteroids. Weekly subcutaneous injection of romiplostim was therefore initiated, and platelet counts were maintained over at 50 × 10(9) /L. She was able to undergo successful LDLT without platelet transfusion seven months after the initiation of romiplostim. Romiplostim was not required after LDLT with improved platelet counts. This case report suggests that romiplostim may be effective in the treatment of thrombocytopenic children with liver cirrhosis and portal hypertension, and in eliminating the need for platelet transfusion during the peri-transplant period., (© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2014
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32. Microarray analysis of gastric mucosa among children with Helicobacter pylori infection.
- Author
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Ikuse T, Ohtsuka Y, Kudo T, Hosoi K, Obayashi N, Jimbo K, Aoyagi Y, Fujii T, Nagata S, and Shimizu T
- Subjects
- Adolescent, Child, Female, Gastric Mucosa, Humans, Male, Microarray Analysis, Real-Time Polymerase Chain Reaction, Helicobacter Infections diagnosis, Helicobacter pylori
- Abstract
Background: Although initial infection with Helicobacter pylori may occur before 5 years of age, the pediatric mucosal immune response against H. pylori is not clear. The aim of the present study was to evaluate immune responses in the H. pylori-infected gastric mucosa of children using microarray and real-time polymerase chain reaction (PCR) analysis of pediatric gastric samples., Methods: Gastric samples were obtained from 12 patients undergoing routine endoscopy of chronic abdominal complaints. Six patients (three boys, three girls) aged 10.1-14.6 years had evidence of H. pylori infection, and the remaining six (three boys, three girls) aged 10.3-15.5 years had no evidence of infection and presented no histological changes associated with gastritis. Microarray and real-time PCR analyses were performed, and the changes in gene expression-related immune response were also analyzed., Results: Using microarray analysis, the total number of significantly upregulated and downregulated genes (fold change >5, P < 0.01) was 21 in the antrum and 16 in the corpus when comparing patients with or without infection. Using real-time PCR, the expression of lipocalin-2 (Lcn2), C-C motif chemokine ligand (CCL) 18, C-X-C motif chemokine ligand (CXCL) 9 and CXCL11 was upregulated, while the expression of pepsinogen (PG) I and PGII was downregulated when comparing patients with or without infection., Conclusions: Lcn2, CCL18, CXCL9, CXCL11, PGI and PGII play important roles in childhood H. pylori infection., (© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.)
- Published
- 2012
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33. Accuracy of orthodontic miniscrew implantation guided by stereolithographic surgical stent based on cone-beam CT-derived 3D images.
- Author
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Qiu L, Haruyama N, Suzuki S, Yamada D, Obayashi N, Kurabayashi T, and Moriyama K
- Subjects
- Bone Screws, Dental Arch surgery, Humans, Image Processing, Computer-Assisted methods, Mandible surgery, Maxilla surgery, Orthodontic Anchorage Procedures standards, Patient Care Planning, Phantoms, Imaging, Reproducibility of Results, Surgery, Computer-Assisted, Tooth Root anatomy & histology, User-Computer Interface, Computer-Aided Design, Cone-Beam Computed Tomography methods, Imaging, Three-Dimensional methods, Orthodontic Anchorage Procedures instrumentation, Stents standards
- Abstract
Objective: To develop surgical stents for cone-beam computed tomography (CBCT) 3-dimensional (3D) image-based stent-guided orthodontic miniscrew implantation and to evaluate its accuracy., Materials and Methods: Ten surgical stents were fabricated with stereolithographic appliances (SLAs) according to 3D CBCT image-based virtual implantation plans. Thirty self-drilling miniscrews were implanted at two to three positions on each side of the maxillary or mandibular posterior arches in three phantoms: 20 guided by 10 surgical stents in two phantoms (stent group) and 10 guided freehand in one phantom (freehand group). Six parameters (mesiodistal and vertical deviations at the corona and apex and mesiodistal and vertical angular deviations) were measured to compare variations between the groups., Results: No root damage was found in the stent group, whereas four of 10 miniscrews contacted with roots in the freehand group. In the stent group, deviations in the mesiodistal and vertical directions were 0.15 ± 0.09 and 0.19 ± 0.19 mm at the corona, respectively, and 0.28 ± 0.23 and 0.33 ± 0.25 mm at the apex, respectively; angular deviations in the mesiodistal and vertical directions were 1.47° ± 0.92° and 2.13° ± 1.48°, respectively. In the freehand group, the corresponding results were 0.48 ± 0.46 mm and 0.94 ± 0.87 mm (corona), 0.81 ± 0.61 mm and 0.78 ± 0.49 mm (apex), and 7.49° ± 6.09° and 6.31° ± 3.82°. Significant differences were found in all six parameters between the two groups (Student's t-test, P < .05)., Conclusions: 3D CBCT image-based SLA-fabricated surgical stents can provide a safe and accurate method for miniscrew implantation.
- Published
- 2012
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34. [Reversible posterior leukoencephalopathy syndrome with the neuroradiological abnormalities predominantly in the brainstem].
- Author
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Abiko M, Ikawa F, Obayashi N, Kajiwara Y, Mitsuhara T, Ichinose N, and Inagawa T
- Subjects
- Antihypertensive Agents administration & dosage, Diagnosis, Differential, Humans, Hypertension complications, Hypertension drug therapy, Infusions, Intravenous, Magnetic Resonance Imaging, Male, Middle Aged, Nicardipine administration & dosage, Posterior Leukoencephalopathy Syndrome drug therapy, Posterior Leukoencephalopathy Syndrome etiology, Posterior Leukoencephalopathy Syndrome pathology, Treatment Outcome, Brain Stem pathology, Posterior Leukoencephalopathy Syndrome diagnosis
- Published
- 2008
35. MRI features of mandibular osteomyelitis: practical criteria based on an association with conventional radiography features and clinical classification.
- Author
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Ariji Y, Izumi M, Gotoh M, Naitoh M, Katoh M, Kuroiwa Y, Obayashi N, Kurita K, Shimozato K, and Ariji E
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Bone Marrow diagnostic imaging, Child, Facial Pain diagnostic imaging, Facial Pain etiology, Facial Pain surgery, Facial Paralysis etiology, Female, Humans, Lip Diseases, Male, Mandibular Diseases diagnostic imaging, Mandibular Diseases surgery, Middle Aged, Osteomyelitis diagnostic imaging, Osteomyelitis surgery, Paralysis etiology, Radiography, Recurrence, Retrospective Studies, Toothache diagnostic imaging, Toothache etiology, Magnetic Resonance Imaging methods, Mandibular Diseases diagnosis, Osteomyelitis diagnosis
- Abstract
Objectives: The aims of this study were (1) to assess the diagnostic power of magnetic resonance imaging (MRI) for mandibular osteomyelitis through comparison with conventional techniques and (2) to establish practical MRI diagnostic criteria in relation to treatment and clinical outcome., Study Design: In 55 subjects, clinically suspected as mandibular osteomyelitis, signal intensities (SI) were evaluated on T1-weighted/short T1 inversion recovery (STIR) images., Results: Forty-seven subjects were definitively diagnosed as having osteomyelitis by pathology studies or clinical course. For the acute or subacute stage, positively associated appearances were low SI on T1-weighted image and extensive high or focal high SI on the STIR image. For chronic stage, appearances of low SI on both T1-weighted and STIR images should be added to those for the acute or subacute stage. These findings support the at-present accepted imaging diagnostic criteria based on bony changes for detection of osteomyelitis., Conclusion: This study confirms that T1-weighted/STIR images are useful for the detection of mandibular osteomyelitis.
- Published
- 2008
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36. Roots of the maxillary first and second molars in horizontal relation to alveolar cortical plates and maxillary sinus: computed tomography assessment for infection spread.
- Author
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Ariji Y, Obayashi N, Goto M, Izumi M, Naitoh M, Kurita K, Shimozato K, and Ariji E
- Subjects
- Adolescent, Adult, Aged, Child, Disease Progression, Female, Humans, Male, Middle Aged, Periapical Diseases physiopathology, Periodontitis physiopathology, Respiratory Mucosa diagnostic imaging, Tooth Diseases physiopathology, Alveolar Process diagnostic imaging, Focal Infection, Dental physiopathology, Maxilla diagnostic imaging, Maxillary Sinus diagnostic imaging, Molar diagnostic imaging, Tomography, X-Ray Computed, Tooth Root diagnostic imaging
- Abstract
The purposes of this study were to investigate the horizontal relationship of the roots of maxillary molars with the cortical plates and the maxillary sinus and to investigate the influence of these relationships on the spread of odontogenic infection. Computed tomography images of 120 control subjects and 49 patients with infection originating in the maxillary first or second molar were investigated. In the control group, more than 60% of the first molar roots contacted both palatal and buccal cortical plates (type A), while such contact was not seen in more than 60% of second molars. The floor of maxillary sinus was most frequently observed at the level between the bifurcation and apices of roots in both first and second molars. In patients with infection, cortical changes were more frequently seen on the buccal side than on the palatal side, and 80% of patients with buccal cortical change showed the position in which the buccal roots were close to the buccal cortical plate. Mucosal thickening of the maxillary sinus was found in 87.8%. The buccopalatal spread of odontogenic infection originating in the maxillary first and second molars was influenced by the horizontal root position in relation to the cortices.
- Published
- 2006
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37. Potential role of chemo-radiation with oral capecitabine in a breast cancer patient with central nervous system relapse.
- Author
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Hikino H, Yamada T, Johbara K, Obayashi N, and Ozaki N
- Subjects
- Administration, Oral, Antimetabolites, Antineoplastic administration & dosage, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Breast Neoplasms pathology, Breast Neoplasms radiotherapy, Capecitabine, Carcinoma, Ductal, Breast radiotherapy, Carcinoma, Ductal, Breast secondary, Combined Modality Therapy, Cyclophosphamide administration & dosage, Deoxycytidine administration & dosage, Deoxycytidine therapeutic use, Doxorubicin administration & dosage, Female, Fluorouracil analogs & derivatives, Humans, Lymphatic Metastasis, Meningeal Neoplasms radiotherapy, Meningeal Neoplasms secondary, Middle Aged, Antimetabolites, Antineoplastic therapeutic use, Breast Neoplasms drug therapy, Carcinoma, Ductal, Breast drug therapy, Deoxycytidine analogs & derivatives, Meningeal Neoplasms drug therapy
- Abstract
A 54-year-old woman underwent mastectomy and axillary lymph node dissection for infiltrating ductal carcinoma with multiple lymph node involvement. The patient received adriamycin 60 mg/m(2) and cyclophosphamide 600 mg/m(2) (AC) followed by weekly paclitaxel 80 mg/m(2) and external irradiation to the local lymph node regions as adjuvant treatment. After 1 year and 5 months, the patient suffered her first recurrence, developing multiple brain and meningeal metastases. CNS involvement was well controlled by oral capecitabine (2400 mg twice daily, on days 1-21 of a 28-day cycle) and external whole brain irradiation of 50 Gy with minimal toxicity. We suggest that capecitabine contributed to the favorable clinical course in this patient and believe that, as an oral agent, this drug may benefit patients with CNS metastases of breast cancer by allowing home-based therapy.
- Published
- 2006
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38. Expression, purification, crystallization and preliminary X-ray diffraction analysis of galactokinase from Pyrococcus horikoshii.
- Author
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Inagaki E, Sakamoto K, Obayashi N, Terada T, Shirouzu M, Bessho Y, Kuroishi C, Kuramitsu S, Shinkai A, and Yokoyama S
- Subjects
- Apoenzymes biosynthesis, Apoenzymes chemistry, Apoenzymes genetics, Apoenzymes isolation & purification, Archaeal Proteins biosynthesis, Archaeal Proteins chemistry, Crystallization, Crystallography, X-Ray, Escherichia coli enzymology, Escherichia coli genetics, Galactokinase biosynthesis, Galactokinase chemistry, Kinetics, Pyrococcus horikoshii genetics, Recombinant Proteins biosynthesis, Recombinant Proteins chemistry, Recombinant Proteins isolation & purification, Archaeal Proteins genetics, Archaeal Proteins isolation & purification, Galactokinase genetics, Galactokinase isolation & purification, Gene Expression Regulation, Archaeal, Pyrococcus horikoshii enzymology
- Abstract
Galactokinase (EC 2.7.1.6) catalyzes the ATP-dependent phosphorylation of alpha-D-galactose to alpha-D-galactose-1-phosphate, in an additional metabolic branch of glycolysis. The apo-form crystal structure of the enzyme has not yet been elucidated. Crystals of galactokinase from Pyrococcus horikoshii were prepared in both the apo form and as a ternary complex with alpha-D-galactose and an ATP analogue. Diffraction data sets were collected to 1.24 A resolution for the apo form and to 1.7 A for the ternary complex form using synchrotron radiation. The apo-form crystals belong to space group C2, with unit-cell parameters a = 108.08, b = 38.91, c = 81.57 A, beta = 109.8 degrees. The ternary complex form was isomorphous with the apo form, except for the length of the a axis. The galactokinase activity of the enzyme was confirmed and the kinetic parameters at 323 K were determined.
- Published
- 2006
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39. Crystal structure of the N-terminal RecA-like domain of a DEAD-box RNA helicase, the Dugesia japonica vasa-like gene B protein.
- Author
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Kurimoto K, Muto Y, Obayashi N, Terada T, Shirouzu M, Yabuki T, Aoki M, Seki E, Matsuda T, Kigawa T, Okumura H, Tanaka A, Shibata N, Kashikawa M, Agata K, and Yokoyama S
- Subjects
- Amino Acid Sequence, Animals, Helminth Proteins classification, Molecular Sequence Data, Molecular Structure, Phylogeny, Protein Structure, Tertiary, RNA Helicases classification, Rec A Recombinases classification, Helminth Proteins chemistry, Planarians enzymology, RNA Helicases chemistry, Rec A Recombinases chemistry
- Abstract
The Dugesia japonica vasa-like gene B (DjVLGB) protein is a DEAD-box RNA helicase of a planarian, which is well known for its strong regenerative capacity. DjVLGB shares sequence similarity to the Drosophila germ-line-specific DEAD-box RNA helicase Vasa, and even higher similarity to its paralogue, mouse PL10. In this study, we solved the crystal structure of the DjVLGB N-terminal RecA-like domain. The overall fold and the structures of the putative ATPase active site of the DjVLGB N-terminal RecA-like domain are similar to those of the previously reported DEAD-box RNA helicase structures. In contrast, the surface structure of the side opposite to the putative ATPase active site is different from those of the other DEAD-box RNA helicases; the characteristic hydrophobic pockets are formed with aromatic and proline residues. These pocket-forming residues are conserved in the PL10-subfamily proteins, but less conserved in the Vasa orthologues and not conserved in the DEAD-box RNA helicases. Therefore, the structural features that we found are characteristic of the PL10-subfamily proteins and might contribute to their biological roles in germ-line development.
- Published
- 2005
- Full Text
- View/download PDF
40. Spread of odontogenic infection originating in the maxillary teeth: computerized tomographic assessment.
- Author
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Obayashi N, Ariji Y, Goto M, Izumi M, Naitoh M, Kurita K, Shimozato K, and Ariji E
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Alveolar Process diagnostic imaging, Bicuspid diagnostic imaging, Cuspid diagnostic imaging, Facial Muscles diagnostic imaging, Fascia diagnostic imaging, Female, Humans, Incisor diagnostic imaging, Lip diagnostic imaging, Male, Masticatory Muscles diagnostic imaging, Maxillary Sinus diagnostic imaging, Middle Aged, Molar diagnostic imaging, Mouth diagnostic imaging, Palate diagnostic imaging, Focal Infection, Dental diagnostic imaging, Maxilla diagnostic imaging, Tomography, X-Ray Computed, Tooth Diseases diagnostic imaging
- Abstract
Objective: The aim of this study was to investigate the pathways of infection originating in the maxillary teeth through the interpretation of computerized tomographic (CT) appearances., Study Design: CT images of 78 patients were analyzed with reference to lateral asymmetry of shape and density of fascial spaces and tissues., Results: Changes in the alveolar cortical plates were observed more frequently in the labial/buccal side than in the palatal side. The facial expression muscles were involved in 23 (19.4%) patients. Infection caused by anterior teeth often spread into the levator labii superioris and levator anguli oris muscles. Deep spread into the fascial space was found in 9 (11.5%) patients. Masticator space changes were predominantly seen in the patients with infection caused by molars. Maxillary sinus changes were found in 57 (71.3%) patients with infection originating in the canines, premolars and molars., Conclusion: Infection spread characteristics are related to the causal teeth, and the pathways were clearly demonstrated on CT images.
- Published
- 2004
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- View/download PDF
41. Solution structure of a BolA-like protein from Mus musculus.
- Author
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Kasai T, Inoue M, Koshiba S, Yabuki T, Aoki M, Nunokawa E, Seki E, Matsuda T, Matsuda N, Tomo Y, Shirouzu M, Terada T, Obayashi N, Hamana H, Shinya N, Tatsuguchi A, Yasuda S, Yoshida M, Hirota H, Matsuo Y, Tani K, Suzuki H, Arakawa T, Carninci P, Kawai J, Hayashizaki Y, Kigawa T, and Yokoyama S
- Subjects
- Amino Acid Sequence, Animals, Humans, Mice, Models, Molecular, Molecular Sequence Data, Protein Structure, Secondary, Sequence Homology, Amino Acid, Solutions chemistry, Nuclear Magnetic Resonance, Biomolecular, Proteins chemistry
- Abstract
The BolA-like proteins are widely conserved from prokaryotes to eukaryotes. The BolA-like proteins seem to be involved in cell proliferation or cell-cycle regulation, but the molecular function is still unknown. Here we determined the structure of a mouse BolA-like protein. The overall topology is alphabetabetaalphaalphabetaalpha, in which beta(1) and beta(2) are antiparallel, and beta(3) is parallel to beta(2). This fold is similar to the class II KH fold, except for the absence of the GXXG loop, which is well conserved in the KH fold. The conserved residues in the BolA-like proteins are assembled on the one side of the protein.
- Published
- 2004
- Full Text
- View/download PDF
42. New index for grading the severity of aortic regurgitation based on the cross-sectional area of vena contracta measured by color Doppler flow mapping.
- Author
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Nozaki S, Mizushige K, Taminato T, Obayashi N, and Matsuo H
- Subjects
- Aged, Aged, 80 and over, Echocardiography, Doppler, Color standards, Humans, Middle Aged, Prospective Studies, Reproducibility of Results, Sensitivity and Specificity, Aortic Valve Insufficiency diagnosis, Echocardiography, Doppler, Color methods, Severity of Illness Index
- Abstract
This study was designed to examine whether the cross-sectional area of vena contracta measured by color Doppler flow mapping (CFM) could be used for assessing aortic regurgitation (AR) and developing an index for grading AR. The 75 study patients with AR were classified into quadrant grades according to New York Heart Association functional class, regurgitant fraction, left ventricular (LV) end-diastolic dimension and LV end-systolic dimension. Using CFM, the cross-sectional area of the vena contracta was measured and it could distinguish all grades without significant overlap. An area of less than 0.10 cm(2) corresponded to Grade 1, 0.10-0.19 cm(2) corresponded to Grade 2, 0.20-0.29 cm(2) corresponded to Grade 3 and an area of more than 0.30 cm(2) corresponded to Grade 4. An area of vena contracta of more than 0.30 cm(2) identified high-scoring AR (Grade 4) in 11 of 11 (sensitivity 100%) and correctly predicted the absence of high-scoring AR in 60 of 64 (specificity 94%). Conversely, there was considerable overlap between the jet distances with the clinical grades. The cross-sectional area of the vena contracta measured by CFM can provide a simple quantitative assessment of AR that correlates well with the clinical grade of AR.
- Published
- 2003
- Full Text
- View/download PDF
43. Effects of nipradilol on venous hemodynamics: evaluation with a Doppler blood flow method.
- Author
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Maekawa K, Saito D, Kobayashi H, Mizuo K, Obayashi N, Uchida S, and Haraoka S
- Subjects
- Adult, Echocardiography, Doppler, Humans, Male, Propranolol pharmacology, Respiration, Hemodynamics drug effects, Propanolamines pharmacology
- Abstract
Nipradilol is a newly synthesized beta-blocker which has a propranolol-like structure and contains a nitrate moiety. To examine the effect of nipradilol on venous blood flow, a single oral dose of nipradilol (6 mg) and propranolol (20 mg) was administered in the same 15 normal volunteers on separate days. Peak flow velocities, flow velocity integrals, and the diameter of the right brachiocephalic vein were measured before and 2 h after drug administration using Doppler echocardiography. These two beta-blockers significantly decreased systolic blood pressure to the same extent as they did heart rate. Nipradilol dilated the venous diameter by 8% and decreased peak flow velocity by 8% during systole and 9% during diastole. The flow velocity integral in one cardiac cycle also decreased significantly by 14%. Propranolol, however, failed to modify these parameters. These results suggest that nipradilol decreased venous return through its nitroglycerin-like direct vasodilating action.
- Published
- 1994
- Full Text
- View/download PDF
44. Effects of inosine on adenosine-induced coronary vasodilation in the open chest dog.
- Author
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Saito D, Mima T, Obayashi N, Uchida S, Maekawa K, Sato T, Mizuo K, Kobayashi H, and Haraoka S
- Subjects
- Adenosine administration & dosage, Adenosine Deaminase metabolism, Animals, Blood Pressure drug effects, Dogs, Female, Heart drug effects, Heart Conduction System drug effects, Heart Rate drug effects, Hypoxanthines pharmacology, Infusions, Intra-Arterial, Inosine administration & dosage, Male, Myocardium enzymology, Myocardium metabolism, Theophylline analogs & derivatives, Theophylline pharmacology, Adenosine pharmacology, Coronary Circulation drug effects, Inosine pharmacology, Vasodilation drug effects
- Abstract
The effects of inosine (CAS 58-63-9) on adenosine-induced coronary vasodilation were studied in open-chest dogs. Inosine and hypoxanthine were infused into the coronary artery at a rate to obtain respective calculated coronary plasma concentrations of 10(-5) mol/l, and the dose-coronary flow response of adenosine was recorded with and without inosine or hypoxanthine infusion. When the maximum coronary dilation was obtained, 10 ml of 2 x 10(-3) mol/l 8-phenyltheophylline (8-PT) solution was injected into the femoral vein. Additionally, adenosine deaminase activity was measured in vitro in the presence of various concentrations of either inosine or hypoxanthine. It was found that inosine, but not hypoxanthine, intensified the coronary vasodilatory effect of adenosine, which was abolished by 8-PT injection: EC50 of adenosine was reduced from 10(-5.43) mol/l to 10(-5.90) mol/l by inosine. Inosine and hypoxanthine did not affect adenosine deaminase activity at concentrations of 10(-4) mol/l or less. These findings indicate that inosine intensifies the coronary vasoactivity of adenosine, independent of inhibition of adenosine deaminase activity.
- Published
- 1993
45. Relationship between pressure-rate product and myocardial oxygen consumption of normal and hypertrophic right ventricles in open-chest dogs.
- Author
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Saito D, Uchida S, Obayashi N, Maekawa K, Mizuo K, Kobayashi H, Tani H, and Haraoka S
- Subjects
- Animals, Coronary Circulation physiology, Dogs, Female, Hemodynamics physiology, Male, Pressure, Hypertrophy, Right Ventricular physiopathology, Myocardium metabolism, Oxygen Consumption physiology, Ventricular Function
- Abstract
There are few reports on the relationship between right ventricular performance and its myocardial oxygen consumption (RVMVO2). The present study was conducted to investigate the relationship between RVMVO2 and the mechanical performance of normal and hypertrophic right ventricles in open-chest dogs. Right ventricular hypertrophy (RVH) was induced by producing chronic right ventricular pressure overload by banding the pulmonary arteries of 8 puppies for 6 months. The experiment was performed under basal conditions and after increasing the RVMVO2 in the eight dogs with RVH as well as in 20 normal dogs. The RVMVO2 showed significant positive relationships with right coronary (RCA) flow, right ventricular systolic pressure, and right ventricular pressure-rate product (PRP) in both the normal right ventricle and RVH hearts. However, the slope between the PRP and RVMVO2 was significantly steeper in the normal right ventricle (RV) than in the hypertrophic RV. When the PRP was normalized for the thickness of the right ventricular free wall, the slope of the two regression lines merged into a single line of fit. These results suggest that the pressure-rate product can be used to predict myocardial oxygen demand not only in the normal RV but also in well-compensated, hypertrophic RV. Isoproterenol induced smaller increases in cardiac output in the dogs with RVH than in those with normal RV. It also appears that the cardiac output of the hypertrophic RV is less sensitive to beta-adrenoceptor stimulation than that of the normal RV.
- Published
- 1993
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- View/download PDF
46. [A case of an idiopathic enlargement of the right atrium, lacking in prominent right atrium contour and mimicking left pericardial defect on the chest X ray].
- Author
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Uchida S, Saito D, Obayashi N, Kobayashi H, Mizuo K, Sato T, Maekawa K, Yamanari H, Matsubara K, and Haraoka S
- Subjects
- Cardiomegaly diagnostic imaging, Diagnosis, Differential, Electrocardiography, Heart Atria, Humans, Male, Middle Aged, Pericardium abnormalities, Radiography, Thoracic, Tomography, X-Ray Computed, Cardiomegaly diagnosis
- Abstract
A 47-year-old man was admitted for evaluation of heart murmur in 1982. On admission, two-dimensional echocardiogram showed a giant right atrium with mild tricuspid regurgitation, but a chest X ray showed no prominent right atrium contour. Echocardiographic finding at various postures and chest X ray with artificial pneumothorax indicated little likelihood of left pericardial defect. An angiocardiogram and computed tomography showed the dilated right atrium with clockwise rotation. There was no indication of right atrial overload. Therefore, we made the diagnosis of an idiopathic enlargement of the right atrium. For about 10 years after discharge, we have followed up this patient. He has received no treatment and has been asymptomatic. On the other hand, echocardiography shows that the right atrium has gradually enlarged. Electrocardiogram has clearly revealed only a tall and slender peaked P wave in chest leads for the last 5 years. This may indicate not only an increasing load on the right atrium but also that the enlarged atrium is getting closer to the walls of the chest. We report this case of an idiopathic enlargement of the right atrium lacking in prominent right atrium contour, and mimicking left pericardial defect on chest X ray.
- Published
- 1993
47. Effects of oral theophylline on sick sinus syndrome.
- Author
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Saito D, Matsubara K, Yamanari H, Obayashi N, Uchida S, Maekawa K, Sato T, Mizuo K, Kobayashi H, and Haraoka S
- Subjects
- Administration, Oral, Adult, Aged, Drug Evaluation, Electrocardiography, Ambulatory drug effects, Female, Follow-Up Studies, Heart Rate drug effects, Humans, Male, Middle Aged, Sick Sinus Syndrome physiopathology, Theophylline administration & dosage, Theophylline pharmacology, Treatment Outcome, Sick Sinus Syndrome drug therapy, Theophylline therapeutic use
- Abstract
Objectives: We sought to determine the effect of theophylline on cardiac pauses in sick sinus syndrome., Background: Sick sinus syndrome, a relatively benign condition, is usually treated with pacemaker implantation without any proved effectiveness. Thus, an appropriate pharmacologic therapy would be useful., Methods: Theophylline (200 to 400 mg/day for 1 month) was initially administered orally to 17 patients with sick sinus syndrome, which is manifested by sinus pauses of > 2.5 s. Eleven of the 17 patients subsequently received theophylline for an additional 8 to 37 months. Twenty-four-hour Holter recordings were obtained before treatment, at the end of 1 month of treatment and then at 6-month intervals., Results: Theophylline decreased the frequency of sinus pauses from 256 +/- 230 to 23 +/- 62 pauses per 24 h and decreased the duration of the longest pauses from 4.7 +/- 1.8 to 2.2 +/- 0.97 s after 1 month of treatment. Subjective symptoms associated with cardiac pauses disappeared in 16 of 17 patients. Ventricular premature beats increased in frequency but did not last longer than two beats. Three patients experienced adverse effects. Nine of the 11 patients receiving long-term treatment had a good outcome, but 2 patients required a pacemaker because of the reappearance of long sinus pauses., Conclusions: The results suggest that oral theophylline may be beneficial for the treatment of patients with sick sinus syndrome.
- Published
- 1993
- Full Text
- View/download PDF
48. Morning increase in hemodynamic response to exercise in patients with angina pectoris.
- Author
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Saito D, Matsubara K, Yamanari H, Uchida S, Obayashi N, Mizuo K, Sato T, Kobayashi H, Maekawa K, and Fukushima K
- Subjects
- Adult, Aged, Electrocardiography, Female, Humans, Male, Middle Aged, Myocardium metabolism, Oxygen Consumption physiology, Reference Values, Angina Pectoris physiopathology, Circadian Rhythm physiology, Exercise Test, Hemodynamics physiology, Myocardial Infarction physiopathology
- Abstract
The present study was conducted to determine whether or not there is diurnal variation in the hemodynamic responses to stimuli that increase myocardial oxygen demand, and the effects of such variation on electrocardiograms (ECG). Fifteen patients with angina pectoris, 17 patients with old myocardial infarction, and 8 healthy controls were examined in this study. Graded exercise stress testing was conducted in the supine position, once in the morning and once in the afternoon, using a bicycle ergometer. A standard 12-lead ECG was recorded before, immediately after, and 3, 5, and 10 min after the end of the exercise. The exercise ECG and blood pressure changes were compared among the groups and, within each group, the results after morning and afternoon exercise were compared. Hemodynamic responses, including heart rate, blood pressure, and the pressure-rate product, showed greater increases in the morning than in the afternoon in angina patients and controls, in association with greater depression of the electrocardiographic ST-segment. In contrast, patients with old myocardial infarction exhibited no difference in hemodynamic responses or the ST-pattern from morning to afternoon. The results suggest that diurnal variation of hemodynamic responses to increased oxygen demand may explain, at least partly, why myocardial ischemia of effort angina is more severe in the morning than in the afternoon.
- Published
- 1993
- Full Text
- View/download PDF
49. Fractal dimensions of ductal patterns in the parotid glands of normal subjects and patients with Sjögren syndrome.
- Author
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Honda E, Domon M, Sasaki T, Obayashi N, and Ida M
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Radiography, Parotid Gland diagnostic imaging, Sjogren's Syndrome diagnostic imaging
- Abstract
Rationale and Objectives: The sialographic ductal patterns of the parotid glands in patients with Sjögren syndrome were compared with those of normal patients by measuring the fractal dimensions., Methods: Fractal dimensions were estimated using the modified pixel dilation method., Results: The mean fractal dimension was 1.64 +/- 0.06 for the normal glands and 1.39 +/- 0.10 for the glands with Sjögren syndrome (P < .005). No correlation between the age or sex and fractal dimension was observed for both groups. In Sjögren syndrome, a significant difference in the fractal dimension was observed between the subgroup having punctuate fillings with a diameter less than 1 mm and the subgroup from 1 to 2 mm (P < .001)., Conclusion: The fractal dimension is useful as a numeric grading of the complexity of the ductal pattern and the progression of parotid disease.
- Published
- 1992
- Full Text
- View/download PDF
50. Papillary fibroelastoma in the left ventricular outflow tract.
- Author
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Uchida S, Obayashi N, Yamanari H, Matsubara K, Saito D, and Haraoka S
- Subjects
- Connective Tissue pathology, Elastic Tissue pathology, Endothelium, Vascular pathology, Female, Fibroma pathology, Fibroma surgery, Heart Neoplasms pathology, Heart Neoplasms surgery, Heart Ventricles pathology, Heart Ventricles surgery, Humans, Middle Aged, Echocardiography, Fibroma diagnostic imaging, Heart Neoplasms diagnostic imaging, Heart Ventricles diagnostic imaging
- Abstract
We report a case of a papillary fibroelastoma originating from the left ventricular endocardium in the outflow tract which was discovered by echocardiography in an asymptomatic patient. Two echocardiographic features were observed: (1) the tumor surface was smooth, and characteristic papillary formation was not detected; and (2) the outline of the mass was clearly defined as a dense echo, with the central, radiolucent, portion surrounded by a highly refractive linear echo at the level of the maximum diameter of the mass. The excised tumor was covered with a gelatinous substance that masked multiple papillae on the surface, but its echolucent center could not be explained by the pathology of the tumor which was solid centrally. Our case indicates that a papillary fibroelastoma may sometimes show echocardiographic findings similar to those of a myxoma, although other investigators have not noted the smooth surface and the echolucent center makes it indistinguishable from a myxoma. Thus, in some cases, it is difficult to distinguish papillary fibroelastoma from myxoma by echocardiography.
- Published
- 1992
- Full Text
- View/download PDF
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