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4. An eosinophil peroxidase activity assay predicts acute exacerbations in post‐operative chronic rhinosinusitis.

Author

Massey, Conner J., Oakley, Gretchen M., Orlandi, Richard R., Ashby, Shaelene, Alt, Jeremiah A., Smith, Kristine A., and Pulsipher, Abigail

Subjects
*DISEASE exacerbation, *ENDOSCOPIC surgery, *DIAGNOSIS, *STEROID drugs, *EOSINOPHILS
Abstract

Key points: EPX activity has been correlated with eCRS diagnosis and baseline disease severity.Herein, EPX activity is shown to correlate with post‐operative antibiotic and steroid use in CRS.EPX activity has potential to act as a prognostic biomarker of CRS disease severity and control. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Chemokine CCL19 and Its Receptors CCR7 and CCRL1 in Chronic Rhinosinusitis

Author

Mahomva,Chengetai, Smith,Kristine, Minkah,Prince, Witt,Benjamin, Oakley,Gretchen, Orlandi,Richard, Alt,Jeremiah, Pulsipher,Abigail, Mahomva,Chengetai, Smith,Kristine, Minkah,Prince, Witt,Benjamin, Oakley,Gretchen, Orlandi,Richard, Alt,Jeremiah, and Pulsipher,Abigail

Abstract

Chengetai R Mahomva,1,* Kristine A Smith,1,* Prince AB Minkah,2 Benjamin L Witt,3 Gretchen M Oakley,1 Richard R Orlandi,1 Jeremiah A Alt,1,2,4 Abigail Pulsipher1,2,4 1Department of Otolaryngology-Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA; 2Department of Molecular Pharmaceutics, University of Utah College of Pharmacy, Salt Lake City, UT, USA; 3Cytopathology Section, University of Utah School of Medicine, Salt Lake City, UT, USA; 4Utah Center for Nanomedicine, University of Utah College of Pharmacy, Salt Lake City, UT, USA*These authors contributed equally to this workCorrespondence: Abigail Pulsipher, University of Utah School of Medicine, Department of Otolaryngology-Head and Neck Surgery, 36 South Wasatch Drive, Salt Lake City, UT, 84112, USA, Tel +1 4342493268, Fax +1 8015855744, Email abigail.pulsipher@utah.eduBackground: CCL19 has been shown to predict disease severity in COVID-19 and treatment response in rheumatoid arthritis. CCL19 can exert both pro- and anti-inflammatory effects and is elevated in chronic rhinosinusitis (CRS). However, its role in CRS remains unknown. This study sought to determine the transcriptional changes in CCL19, its receptors, and associated cytokines and their association with disease severity in CRS.Methods: A clinical database of control subjects and patients with CRS was examined. Lund-Kennedy, Lund-Mackay, Sinonasal Outcomes Test 22 (SNOT-22), and rhinosinusitis disability index (RSDI) scores were collected at enrollment. mRNA was extracted from sinonasal tissues and subjected to multiplex gene expression analysis. Gene transcript differences between patients with CRS and controls were compared and correlated with disease severity metrics. Immunohistochemical analyses of CCL19, CCR7, and CCRL1 were conducted to compare differences in protein expression between cohorts. A subgroup analysis was performed to compare transcriptional and protein expression difference

Published
2024

7. Investigation of the Genetic Determinants of Telangiectasia and Solid Organ Arteriovenous Malformation Formation in Hereditary Hemorrhagic Telangiectasia (HHT).

Author

Whitehead, Kevin J., Toydemir, Doruk, Wooderchak-Donahue, Whitney, Oakley, Gretchen M., McRae, Bryan, Putnam, Angelica, McDonald, Jamie, and Bayrak-Toydemir, Pinar

Subjects
HEREDITARY hemorrhagic telangiectasia, ARTERIOVENOUS malformation, TELANGIECTASIA, SOMATIC mutation, GALLBLADDER, LUNGS, CANCER genes
Abstract

Telangiectases and arteriovenous malformations (AVMs) are the characteristic lesions of Hereditary Hemorrhagic Telangiectasia (HHT). Somatic second-hit loss-of-function variations in the HHT causative genes, ENG and ACVRL1, have been described in dermal telangiectasias. It is unclear if somatic second-hit mutations also cause the formation of AVMs and nasal telangiectasias in HHT. To investigate the genetic mechanism of AVM formation in HHT, we evaluated multiple affected tissues from fourteen individuals. DNA was extracted from fresh/frozen tissue of 15 nasal telangiectasia, 4 dermal telangiectasia, and 9 normal control tissue biopsies, from nine unrelated individuals with HHT. DNA from six formalin-fixed paraffin-embedded (FFPE) AVM tissues (brain, lung, liver, and gallbladder) from five individuals was evaluated. A 736 vascular malformation and cancer gene next-generation sequencing (NGS) panel was used to evaluate these tissues down to 1% somatic mosaicism. Somatic second-hit mutations were identified in three in four AVM biopsies (75%) or half of the FFPE (50%) samples, including the loss of heterozygosity in ENG in one brain AVM sample, in which the germline mutation occurred in a different allele than a nearby somatic mutation (both are loss-of-function mutations). Eight of nine (88.9%) patients in whom telangiectasia tissues were evaluated had a somatic mutation ranging from 0.68 to 1.96% in the same gene with the germline mutation. Six of fifteen (40%) nasal and two of four (50%) dermal telangiectasia had a detectable somatic second hit. Additional low-level somatic mutations in other genes were identified in several telangiectasias. This is the first report that nasal telangiectasias and solid organ AVMs in HHT are caused by very-low-level somatic biallelic second-hit mutations. [ABSTRACT FROM AUTHOR]

Published
2024
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9. International consensus statement on allergy and rhinology: Sinonasal tumors

Author

Kuan, Edward C., primary, Wang, Eric W., additional, Adappa, Nithin D., additional, Beswick, Daniel M., additional, London, Nyall R., additional, Su, Shirley Y., additional, Wang, Marilene B., additional, Abuzeid, Waleed M., additional, Alexiev, Borislav, additional, Alt, Jeremiah A., additional, Antognoni, Paolo, additional, Alonso‐Basanta, Michelle, additional, Batra, Pete S., additional, Bhayani, Mihir, additional, Bell, Diana, additional, Bernal‐Sprekelsen, Manuel, additional, Betz, Christian S., additional, Blay, Jean‐Yves, additional, Bleier, Benjamin S., additional, Bonilla‐Velez, Juliana, additional, Callejas, Claudio, additional, Carrau, Ricardo L., additional, Casiano, Roy R., additional, Castelnuovo, Paolo, additional, Chandra, Rakesh K., additional, Chatzinakis, Vasileios, additional, Chen, Simon B., additional, Chiu, Alexander G., additional, Choby, Garret, additional, Chowdhury, Naweed I., additional, Citardi, Martin J., additional, Cohen, Marc A., additional, Dagan, Roi, additional, Dalfino, Gianluca, additional, Dallan, Iacopo, additional, Dassi, Camila Soares, additional, de Almeida, John, additional, Tos, Angelo P. Dei, additional, DelGaudio, John M., additional, Ebert, Charles S., additional, El‐Sayed, Ivan H., additional, Eloy, Jean Anderson, additional, Evans, James J., additional, Fang, Christina H., additional, Farrell, Nyssa F., additional, Ferrari, Marco, additional, Fischbein, Nancy, additional, Folbe, Adam, additional, Fokkens, Wytske J., additional, Fox, Meha G., additional, Lund, Valerie J., additional, Gallia, Gary L., additional, Gardner, Paul A., additional, Geltzeiler, Mathew, additional, Georgalas, Christos, additional, Getz, Anne E., additional, Govindaraj, Satish, additional, Gray, Stacey T., additional, Grayson, Jessica W., additional, Gross, Bradley A., additional, Grube, Jordon G., additional, Guo, Ruifeng, additional, Ha, Patrick K., additional, Halderman, Ashleigh A., additional, Hanna, Ehab Y., additional, Harvey, Richard J., additional, Hernandez, Stephen C., additional, Holtzman, Adam L., additional, Hopkins, Claire, additional, Huang, Zhigang, additional, Huang, Zhenxiao, additional, Humphreys, Ian M., additional, Hwang, Peter H., additional, Iloreta, Alfred M., additional, Ishii, Masaru, additional, Ivan, Michael E., additional, Jafari, Aria, additional, Kennedy, David W., additional, Khan, Mohemmed, additional, Kimple, Adam J., additional, Kingdom, Todd T., additional, Knisely, Anna, additional, Kuo, Ying‐Ju, additional, Lal, Devyani, additional, Lamarre, Eric D., additional, Lan, Ming‐Ying, additional, Le, Hien, additional, Lechner, Matt, additional, Lee, Nancy Y., additional, Lee, Jivianne K., additional, Lee, Victor H., additional, Levine, Corinna G., additional, Lin, Jin‐Ching, additional, Lin, Derrick T., additional, Lobo, Brian C., additional, Locke, Tran, additional, Luong, Amber U., additional, Magliocca, Kelly R., additional, Markovic, Svetomir N., additional, Matnjani, Gesa, additional, McKean, Erin L., additional, Meço, Cem, additional, Mendenhall, William M., additional, Michel, Loren, additional, Na'ara, Shorook, additional, Nicolai, Piero, additional, Nuss, Daniel W., additional, Nyquist, Gurston G., additional, Oakley, Gretchen M., additional, Omura, Kazuhiro, additional, Orlandi, Richard R., additional, Otori, Nobuyoshi, additional, Papagiannopoulos, Peter, additional, Patel, Zara M., additional, Pfister, David G., additional, Phan, Jack, additional, Psaltis, Alkis J., additional, Rabinowitz, Mindy R., additional, Ramanathan, Murugappan, additional, Rimmer, Ryan, additional, Rosen, Marc R., additional, Sanusi, Olabisi, additional, Sargi, Zoukaa B., additional, Schafhausen, Philippe, additional, Schlosser, Rodney J., additional, Sedaghat, Ahmad R., additional, Senior, Brent A., additional, Shrivastava, Raj, additional, Sindwani, Raj, additional, Smith, Timothy L., additional, Smith, Kristine A., additional, Snyderman, Carl H., additional, Solares, C. Arturo, additional, Sreenath, Satyan B., additional, Stamm, Aldo, additional, Stölzel, Katharina, additional, Sumer, Baran, additional, Surda, Pavol, additional, Tajudeen, Bobby A., additional, Thompson, Lester D. R., additional, Thorp, Brian D., additional, Tong, Charles C. L., additional, Tsang, Raymond K., additional, Turner, Justin H., additional, Turri‐Zanoni, Mario, additional, Udager, Aaron M., additional, van Zele, Thibaut, additional, VanKoevering, Kyle, additional, Welch, Kevin C., additional, Wise, Sarah K., additional, Witterick, Ian J., additional, Won, Tae‐Bin, additional, Wong, Stephanie N., additional, Woodworth, Bradford A., additional, Wormald, Peter‐John, additional, Yao, William C., additional, Yeh, Chien‐Fu, additional, Zhou, Bing, additional, Palmer, James N., additional, Abiri, Arash, additional, Adams, Carrie D., additional, Ayoub, Noel F., additional, Bitner, Benjamin F., additional, Boyd, Jacob T., additional, Chang, Michael T., additional, Chapurin, Nikita, additional, Chaskes, Mark B., additional, Chua, Andy, additional, Chung, Sei Y., additional, Contrera, Kevin J., additional, Dilley, Katelyn K., additional, Dutra, André Zanette, additional, Eide, Jacob G., additional, Fenberg, Rachel, additional, Godse, Neal R., additional, Jawad, Basit, additional, Johnson, Jared, additional, Johnson, B. Jake, additional, Judd, Ryan, additional, Khalife, Sarah, additional, Khosravi, Pooya, additional, Kolarski, Mirko Manojlovic, additional, Kong, Keonho A., additional, Kshirsagar, Rijul S., additional, Lee, Joseph S., additional, Lin, Tian‐Yun, additional, McCormick, Justin P., additional, Melder, Katie, additional, Morse, Elliot, additional, Nguyen, Theodore V., additional, Norwood, Timothy G., additional, Pang, Jonathan C., additional, Parsel, Sean M., additional, Patel, Prayag S., additional, Ringel, Barak, additional, Schneider, Alexander L., additional, Spielman, Daniel B., additional, Spock, Todd, additional, and Vasudev, Milind, additional

Published
2023
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17. International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Author

Orlandi, Richard, Kingdom, Todd T., Smith, Timothy L., Bleier, Benjamin, DeConde, Adam, Luong, Amber, Poetker, David M., Soler, Zachary, Welch, Kevin C., Wise, Sarah K., Adappa, Nithin, Alt, Jeremiah A., Anselmo-Lima, Wilma Terezinha, Bachert, Claus, Baroody, Fuad M., Batra, Pete S., Bernal-Sprekelsen, Manuel, Beswick, Daniel, Bhattacharyya, Neil, Chandra, Rakesh K., Chang, Eugene, Chiu, Alexander, Chowdhury, Naweed, Citardi, Martin J., Cohen, Noam, Conley, David B., DelGaudio, John, Desrosiers, Martin, Douglas, Richard, Anderson Eloy, Jean, Fokkens, Wytske J., Gray, Stacey T., Gudis, David A., Hamilos, Daniel L., Han, Joseph K., Harvey, Richard, Hellings, Peter, Holbrook, Eric H., Hopkins, Claire, Hwang, Peter, Javer, Amin R., Jiang, Rong-San, Kennedy, David, Kern, Robert, Laidlaw, Tanya, Lal, Devyani, Lane, Andrew, Lee, Heung-Man, Lee, Jivianne T., Levy, Joshua M., Lin, Sandra Y., Lund, Valerie, McMains, Kevin C., Metson, Ralph, Mullol, Joaquim, Naclerio, Robert, Oakley, Gretchen, Otori, Nobuyoshi, Palmer, James N., Parikh, Sanjay R., Passali, Desiderio, Patel, Zara, Peters, Anju, Philpott, Carl, Psaltis, Alkis J., Ramakrishnan, Vijay R., Ramanathan, Murugappan, Roh, Hwan-Jung, Rudmik, Luke, Sacks, Raymond, Schlosser, Rodney J., Sedaghat, Ahmad, Senior, Brent, Sindwani, Raj, Smith, Kristine, Snidvongs, Kornkiat, Stewart, Michael, Suh, Jeffrey, Tan, Bruce K., Turner, Justin H., van Drunen, Cornelis M., Voegels, Richard, Wang, De-Yun, Woodworth, Bradford A., Wormald, Peter-John, Wright, Erin D., Yan, Carol, Zhang, Luo, and Zhou, Bing

Abstract

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS.

Published
2021

19. sj-docx-1-ajr-10.1177_19458924211046719 - Supplemental material for Cystic Fibrosis Increases Long-Term Revision Rates of Endoscopic Sinus Surgery in Patients With Comorbid Chronic Rhinosinusitis

Author

Smith, Kristine A., Gill, Amarbir S., Beswick, Daniel M., Meeks, Huong, Oakley, Gretchen M., Yim, Michael, Curtin, Karen, Orlandi, Richard R., and Alt, Jeremiah A.

Subjects
110315 Otorhinolaryngology, FOS: Clinical medicine, humanities
Abstract

Supplemental material, sj-docx-1-ajr-10.1177_19458924211046719 for Cystic Fibrosis Increases Long-Term Revision Rates of Endoscopic Sinus Surgery in Patients With Comorbid Chronic Rhinosinusitis by Kristine A. Smith, Amarbir S. Gill, Daniel M. Beswick, Huong Meeks, Gretchen M. Oakley, Michael Yim, Karen Curtin, Richard R. Orlandi and Jeremiah A. Alt in American Journal of Rhinology & Allergy

Published
2021
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20. sj-pdf-1-aor-10.1177_00034894211005986 – Supplemental material for Sleep Dysfunction is an Independent Predictor of Productivity Losses in Patients with Chronic Rhinosinusitis

Author

Oakley, Gretchen M., Smith, Kristine A., Shaelene Ashby, Orlandi, Richard R., and Alt, Jeremiah A.

Subjects
110315 Otorhinolaryngology, FOS: Clinical medicine
Abstract

Supplemental material, sj-pdf-1-aor-10.1177_00034894211005986 for Sleep Dysfunction is an Independent Predictor of Productivity Losses in Patients with Chronic Rhinosinusitis by Gretchen M. Oakley, Kristine A. Smith, Shaelene Ashby, Richard R. Orlandi and Jeremiah A. Alt in Annals of Otology, Rhinology & Laryngology

Published
2021
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23. Transcriptional Changes in Chronic Rhinosinusitis with Asthma Favor a Type 2 Molecular Endotype Independent of Polyp Status [Corrigendum]

Author

Gill,Amarbir S, Pulsipher,Abigail, Sumsion,Jorgen S, Oakley,Gretchen M, Leclair,Laurie W, Howe,Heather, Orlandi,Richard R, Alt,Jeremiah A, Gill,Amarbir S, Pulsipher,Abigail, Sumsion,Jorgen S, Oakley,Gretchen M, Leclair,Laurie W, Howe,Heather, Orlandi,Richard R, and Alt,Jeremiah A

Abstract

Gill AS, Pulsipher A, Sumsion JS, et al. J Asthma Allergy. 2021;14:405– 413   The authors have advised that they missed including a Funding statement in their paper. The following statement should have been included on page 412 of the published paper. Funding This study was funded by the Flight Attendant Medical Research Institute (CIA160008 to J.A.A.). The authors apologize for this error.   Read the original article

Published
2021

24. Cell Adhesion Molecules are Upregulated and May Drive Inflammation in Chronic Rhinosinusitis with Nasal Polyposis

Author

Blight,Brennan J, Gill,Amarbir S, Sumsion,Jorgen S, Pollard,Chelsea E, Ashby,Shaelene, Oakley,Gretchen M, Alt,Jeremiah A, Pulsipher,Abigail, Blight,Brennan J, Gill,Amarbir S, Sumsion,Jorgen S, Pollard,Chelsea E, Ashby,Shaelene, Oakley,Gretchen M, Alt,Jeremiah A, and Pulsipher,Abigail

Abstract

Brennan J Blight, Amarbir S Gill, Jorgen S Sumsion, Chelsea E Pollard, Shaelene Ashby, Gretchen M Oakley, Jeremiah A Alt, Abigail Pulsipher Division of Otolaryngology-Head and Neck Surgery, Rhinology-Sinus and Skull Base Surgery Program, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USACorrespondence: Abigail PulsipherDivision of Otolaryngology-Head and Neck Surgery, Rhinology-Sinus and Skull Base Surgery Program, Department of Surgery, University of Utah School of Medicine, 50 North Medical Drive, Room 3C120, Salt Lake City, UT, 84132, USAEmail abigail.pulsipher@utah.eduPurpose: Chronic rhinosinusitis with nasal polyps (CRSwNP) is predominantly characterized by eosinophil- and T helper 2 cell (Th2)-biased inflammation. Integrins and intercellular adhesion molecules (ICAMs) are superfamilies of cell adhesion molecules (CAMs) that facilitate the recruitment and trafficking of immune cells and have been implicated in coordinating eosinophil and Th2 cell adhesion and signaling in asthma. The roles of CAMs in CRSwNP, however, remain poorly understood. The purpose of this study was to characterize the systemic and local expression of CAMs and identify which CAMs are potentially involved in CRSwNP pathology.Materials and Methods: A prospective observational study was conducted using peripheral blood and anterior ethmoid tissues of patients with CRSwNP (n=32) and controls (n=15). Multiplex gene analysis and Pearson correlations were performed to identify associations between systemically and locally expressed CAMs. Based on the gene expression results, immunohistochemical evaluation and quantification of cells expressing integrins ITGAM, ITGAX, and ITGB2, as well as ICAM-3 in sinonasal tissues were conducted to compare local protein expression patterns.Results: Integrin and ICAM genes were significantly elevated in the blood (p< 0.001 to p< 0.05) and sinuses (p< 0.0003 to p< 0.05) of patients with CRSwNP compa

Published
2021

25. Transcriptional Changes in Chronic Rhinosinusitis with Asthma Favor a Type 2 Molecular Endotype Independent of Polyp Status

Author

Gill,Amarbir S, Pulsipher,Abigail, Sumsion,Jorgen S, Oakley,Gretchen M, Leclair,Laurie W, Howe,Heather, Orlandi,Richard R, Alt,Jeremiah A, Gill,Amarbir S, Pulsipher,Abigail, Sumsion,Jorgen S, Oakley,Gretchen M, Leclair,Laurie W, Howe,Heather, Orlandi,Richard R, and Alt,Jeremiah A

Abstract

Amarbir S Gill, 1 Abigail Pulsipher, 1 Jorgen S Sumsion, 2 Gretchen M Oakley, 1 Laurie W Leclair, 3 Heather Howe, 3 Richard R Orlandi, 1 Jeremiah A Alt 1 1Division of Otolaryngology – Head and Neck Surgery, Department of Surgery, University of Utah, Salt Lake City, UT, USA; 2School of Medicine, University of Utah, Salt Lake, USA; 3Department of Pulmonology/Critical Care Medicine, University of Utah, Salt Lake City, UT, USACorrespondence: Jeremiah A AltDivision of Otolaryngology – Head & Neck Surgery, Department of Surgery, University of Utah School of Medicine, 50 North Medical Drive, Room 3C120, Salt Lake City, UT, 84132, USATel +1 801 585-7143Fax +1 801 585-5744Email jeremiah.alt@hsc.utah.eduBackground: Data regarding the inflammatory profile of patients with asthma and chronic rhinosinusitis (CRS-A) with (CRSwNP-A) and without (CRSsNP-A) nasal polyposis remain limited.Objective: Define and compare systemic transcriptional changes in patients with CRS-A to those with non-asthma-related CRS with (CRSwNP) and without nasal polyposis (CRSsNP).Methods: Thirty-four patients with CRS-A (n=19) and CRS (n=15) were prospectively enrolled into an observational study. Demographic information and subjective and objective disease severity measures were recorded. Multiplex gene expression analysis of mRNA extracted from peripheral blood was performed. A total of 594 genes associated with innate/adaptive immunity were analyzed using NanoString technology. Gene expression ratios were reported for genes that were differentially expressed among these cohorts. Linear regression analysis was used to compare the mRNA transcript copy numbers for each gene with disease severity.Results: There was no significant difference in age, gender, nasal polyposis, or health-related quality of life measures between the two groups (p> 0.05). HLA class II histocompatibility antigen, DRB3-1 beta chain (HLA-DRB3) was significantly upregulated in the peripheral blood

Published
2021

29. International consensus statement on allergy and rhinology: rhinosinusitis 2021

Author

Orlandi, Richard R., primary, Kingdom, Todd T., additional, Smith, Timothy L., additional, Bleier, Benjamin, additional, DeConde, Adam, additional, Luong, Amber U., additional, Poetker, David M., additional, Soler, Zachary, additional, Welch, Kevin C., additional, Wise, Sarah K., additional, Adappa, Nithin, additional, Alt, Jeremiah A., additional, Anselmo‐Lima, Wilma Terezinha, additional, Bachert, Claus, additional, Baroody, Fuad M., additional, Batra, Pete S., additional, Bernal‐Sprekelsen, Manuel, additional, Beswick, Daniel, additional, Bhattacharyya, Neil, additional, Chandra, Rakesh K., additional, Chang, Eugene H., additional, Chiu, Alexander, additional, Chowdhury, Naweed, additional, Citardi, Martin J., additional, Cohen, Noam A., additional, Conley, David B., additional, DelGaudio, John, additional, Desrosiers, Martin, additional, Douglas, Richard, additional, Eloy, Jean Anderson, additional, Fokkens, Wytske J., additional, Gray, Stacey T., additional, Gudis, David A., additional, Hamilos, Daniel L., additional, Han, Joseph K., additional, Harvey, Richard, additional, Hellings, Peter, additional, Holbrook, Eric H., additional, Hopkins, Claire, additional, Hwang, Peter, additional, Javer, Amin R., additional, Jiang, Rong‐San, additional, Kennedy, David, additional, Kern, Robert, additional, Laidlaw, Tanya, additional, Lal, Devyani, additional, Lane, Andrew, additional, Lee, Heung‐Man, additional, Lee, Jivianne T., additional, Levy, Joshua M., additional, Lin, Sandra Y., additional, Lund, Valerie, additional, McMains, Kevin C., additional, Metson, Ralph, additional, Mullol, Joaquim, additional, Naclerio, Robert, additional, Oakley, Gretchen, additional, Otori, Nobuyoshi, additional, Palmer, James N., additional, Parikh, Sanjay R., additional, Passali, Desiderio, additional, Patel, Zara, additional, Peters, Anju, additional, Philpott, Carl, additional, Psaltis, Alkis J., additional, Ramakrishnan, Vijay R., additional, Ramanathan, Murugappan, additional, Roh, Hwan‐Jung, additional, Rudmik, Luke, additional, Sacks, Raymond, additional, Schlosser, Rodney J., additional, Sedaghat, Ahmad R., additional, Senior, Brent A., additional, Sindwani, Raj, additional, Smith, Kristine, additional, Snidvongs, Kornkiat, additional, Stewart, Michael, additional, Suh, Jeffrey D., additional, Tan, Bruce K., additional, Turner, Justin H., additional, van Drunen, Cornelis M., additional, Voegels, Richard, additional, Wang, De Yun, additional, Woodworth, Bradford A., additional, Wormald, Peter‐John, additional, Wright, Erin D., additional, Yan, Carol, additional, Zhang, Luo, additional, and Zhou, Bing, additional

Published
2021
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37. Cystic Fibrosis Increases Long-Term Revision Rates of Endoscopic Sinus Surgery in Patients With Comorbid Chronic Rhinosinusitis.

Author

Smith, Kristine A., Gill, Amarbir S., Beswick, Daniel M., Meeks, Huong, Oakley, Gretchen M., Yim, Michael, Curtin, Karen, Orlandi, Richard R., and Alt, Jeremiah A.

Subjects
ENDOSCOPIC surgery, CYSTIC fibrosis, COMORBIDITY, PROPORTIONAL hazards models, LOGISTIC regression analysis, SINUSITIS
Abstract

Background: Comorbid chronic rhinosinusitis (CRS) of adulthood is increasing among patients with cystic fibrosis (CF) due to improved median survival. However, little is known about the natural history of endoscopic sinus surgery (ESS) in this cohort. The objective of this study was to evaluate the revision rate of ESS and associated risk factors among adults with CRS and CF (CRSwCF). Methods: The Utah Population Database was queried for patients age >18 with CRS who underwent at least one ESS between 1996 and 2018. Demographic information and ESS history were collected and compared for CRSwCF versus CRS without CF (CRSsCF) using chi-square and t-tests. Risk factors for revision were analyzed using Cox proportional hazard models and logistic regression analysis. Results: A total of 34 050 patients (33 639 CRSsCF and 411 CRSwCF) were included in the final analysis. The mean duration of follow-up was 9.3 and 9.3 years, respectively (P =.98). Adult patients with CF were significantly more likely to undergo revision ESS (18.7%) than those without CF (13.4%; P <.01). Logistic regression analysis indicated that a diagnosis of CF independently elevated the risk for revision ESS in the absence of nasal polyps (odds ratio [OR] 2.18, confidence interval [CI] 1.34-3.54), asthma (OR 1.36, CI 0.94-1.98), and allergies (OR 1.29, CI 0.90-1.73). Conclusion: In the era before highly effective modulator therapies, the mean revision rate of ESS among adults with CRSwCF was 18.7%, significantly greater than that of adults with CRSsCF. CF was an independent risk factor for revision ESS in the absence of nasal polyps, asthma, and allergies. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Comorbidities Known to Affect Physical Function Negatively Impact Baseline Health-Related Quality-of-Life in Patients With Chronic Rhinosinusitis.

Author

Gill, Amarbir S., Ashby, Shaelene, Oakley, Gretchen M., Steele, Toby O., Menjivar, Dennis, Orlandi, Richard R., and Alt, Jeremiah A.

Abstract

Background: Medical comorbidities are commonly encountered in chronic rhinosinusitis (CRS) and may impact both physical function and patient reported health-related quality-of-life (HRQOL). The functional comorbidity index (FCI) is designed to elucidate the role of comorbidities on functional prognosis. The objective of this study was to understand the impact of comorbidities known to impact physical function on baseline HRQOL using the FCI. Methodology: Patients meeting diagnostic criteria for CRS were prospectively enrolled in a cross-sectional study. Responses from the Sinonasal Outcomes Test-22 (SNOT-22), a measure of patient HRQOL, as well as the Lund-Kennedy and Lund-Mackay scores were recorded at enrollment. FCI was calculated retrospectively using the electronic medical record. Information was collected and compared for patients without (CRSsNP) and with nasal polyps (CRSwNP) using chi-square and t-tests. Spearman's correlations, followed by multivariate regression analysis, were used to assess the association between FCI and SNOT-22 scores. Results: One hundred and three patients met inclusion criteria for analysis. There were no significant differences in age, gender, and SNOT-22 scores between patients with CRSsNP and those with CRSwNP. FCI was significantly and independently associated with worse SNOT-22 scores (P =.012). FCI did not correlate with endoscopy and computed tomography scores. The mean FCI for patients with CRSsNP and CRSwNP was 2.02 and 2.24, respectively, and did not differ significantly between the two cohorts (P =.565). Conclusions: Major medical comorbidities known to affect physical function are associated with worse SNOT-22 scores in patients with CRS as measured by the FCI. [ABSTRACT FROM AUTHOR]

Published
2022
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