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48 results on '"Oakhill, Anthony"'

13. Minimal residual disease status as a predictor of relapse after allogeneic bone marrow transplantation for children with acute lymphoblastic leukaemia

Author

Knechtli, Christopher J. C., Goulden, Nicholas J., Hancock, Jeremy P., Harris, Emma L., Garland, Russell J., Jones, Claire G., Grandage, Victoria L. G., Rowbottom, Anthony W., Green, Ann F., Clarke, Emer, Lankester, Alan W., Potter, Michael N., Cornish, Jacqueline M., Pamphilon, Derwood H., Steward, Colin G., and Oakhill, Anthony

Published
1998

21. Decline in incidence of medulloblastoma in children

Author

Thorne, Robert N., Pearson, Andrew D.J., Nicoll, James A.R., Coakham, Hugh B., Oakhill, Anthony, Mott, Martin G., and Foreman, Nicholas K.

Subjects
Medulloblastoma -- Demographic aspects, Tumors in children -- Demographic aspects, Vitamin therapy -- Usage, Folic acid -- Usage, Health
Abstract

Background. Medulloblastoma is one of the most common intracranial tumors in children. The perception that the incidence of this tumor has declined is reinforced by a decline in enrollment to international trials for the disease. Methods. A retrospective population-based study of children younger than 15 years whose brain tumors were reviewed histopathologically was performed in the county of Avon, in the southwest region of England from 1976 to 1991. Then, the incidence of medulloblastoma was studied in the noncontiguous southwest and northern regions of England, with a combined childhood population base of 20.0 million child years for the period 1976-1991. Results. In Avon, 16 children with medulloblastoma presented in the period 1976-1984 and 2 in the period 1985-1991, representing a decrease in incidence from 9.6 per million per year to 1.7 per million per year. The incidence of medulloblastoma in the combined southwest and northern regions showed a significant (P = 0.006) decline from 5.5 per million per year in the period 1976-1984 to 2.8 in the period 1985-1991. Considered individually, the decline in the southwest (from 6.2 per million per year to 2.8 per million per year) was significant but that in the Northern region (from 4.7 to 2.7) was not. Conclusions. In this report, a decline in the incidence of medulloblastoma was shown. In a recent case control study, a protective effect of maternal folate, iron, and multivitamin supplementation against primitive neuroectodermal tumors, including medulloblastoma was found. The introduction of periconceptional multivitamin supplementation in the 1980s may have caused this significant decline in the incidence of medulloblastoma.

Published
1994

23. Children With Acute Lymphoblastic Leukemia Who Receive T-Cell–Depleted HLA Mismatched Marrow Allografts From Unrelated Donors Have an Increased Incidence of Primary Graft Failure but a Similar Overall Transplant Outcome

Author

Green, Ann, Clarke, Emer, Hunt, Linda, Canterbury, Andrew, Lankester, Alan, Hale, Geoff, Waldmann, Herman, Goodman, Sally, Cornish, Jacqueline M., Marks, David I., Steward, Colin G., Oakhill, Anthony, and Pamphilon, Derwood H.

Published
1999
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29. CMV Specific Immunotherapy: How Many Patients Will Benefit?.

Author

Garland, Russell J., primary, Diamanti, Paraskevi, additional, West, Samantha E., additional, Green, Ann, additional, Carrington, David, additional, Groves, Sarah J., additional, Winship, Kerri L., additional, Robinson, Stephen P., additional, Oakhill, Anthony, additional, Cornish, Jacqueline M., additional, Pamphilon, Derwood H., additional, Marks, David I., additional, Goulden, Nicholas J., additional, Blair, Allison G., additional, and Steward, Colin G., additional

Published
2004
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30. Alemtuzumab (Campath IH) in Conditioning Therapy with Cyclophosphamide and Total Body Irradiation in Matched and Mismatched Unrelated Donor Transplantation of Children with Acute Lymphoblastic Leukaemia: A Report from 3 U.K. Centres.

Author

Gharib, Maged I., primary, Greenfield, Hayley M., additional, Wynn, Robert F., additional, Veys, Paul, additional, Naik, Paru, additional, Will, Andrew M., additional, Cornish, Jacqueline M., additional, Oakhill, Anthony, additional, and Goulden, Nicholas J., additional

Published
2004
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33. Minimal Residual Disease Status Before Allogeneic Bone Marrow Transplantation Is an Important Determinant of Successful Outcome for Children and Adolescents With Acute Lymphoblastic Leukemia

Author

Knechtli, Christopher J.C., primary, Goulden, Nicholas J., additional, Hancock, Jeremy P., additional, Grandage, Victoria L.G., additional, Harris, Emma L., additional, Garland, Russell J., additional, Jones, Claire G., additional, Rowbottom, Anthony W., additional, Hunt, Linda P., additional, Green, Ann F., additional, Clarke, Emer, additional, Lankester, Alan W., additional, Cornish, Jacqueline M., additional, Pamphilon, Derwood H., additional, Steward, Colin G., additional, and Oakhill, Anthony, additional

Published
1998
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35. Decline in incidence of medulloblastoma in children

Author

Morland, Bruce J., primary, Parkes, Sheila E., additional, Thorne, Robert N., additional, Pearson, Andrew D. J., additional, Nicoll, James A. R., additional, Coakham, Hugh B., additional, Oakhill, Anthony, additional, Mott, Martin G., additional, and Foreman, Nicholas K., additional

Published
1995
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41. Chemotherapy in the management of infantile fibrosarcoma

Author

Kynaston, J. Anne, primary, Malcolm, Archie J., additional, Craft, Alan W., additional, Davies, Stella M., additional, Jones, Patricia H. Morris, additional, King, Derek J., additional, Mitchell, Christopher D., additional, Oakhill, Anthony, additional, and Stiller, Charles A., additional

Published
1993
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43. The use of stimulated granulocyte transfusions to prevent recurrence of past severe infections after allogeneic stem cell transplantation.

Author

Paul Kerr, J., Liakopolou, Effie, Brown, Jessica, Cornish, Jacqueline M., Fleming, David, Massey, Edwin, Oakhill, Anthony, Pamphilon, Derwood H., Robinson, Stephen P., Totem, April, Valencia, Alexandra M.P.I., and Marks, David I.

Subjects
ASPERGILLOSIS, STEM cell transplantation, GRANULOCYTES, BLOOD transfusion
Abstract

Summary. The predictable neutropenia that follows allogeneic stem cell transplantation (ASCT) may be associated with recurrence of previous life-threatening infection. We describe nine patients with either previous invasive aspergillosis (IA) or considered to be at high risk of developing IA who underwent ASCT with prophylactic granulocyte transfusions. The study group, when compared with a control group, had a significant reduction in the incidence and duration of fevers (P < 0·05) and maximum C-reactive protein (P < 0·05). There were significantly fewer days of neutropenia (P < 0·05). There was also radiological improvement of pulmonary infiltrates in four out of seven assessable patients. No serious toxicity was encountered in donors or recipients. We conclude that prophylactic granulocyte donations can be given safely, and that they significantly reduce the number of days of neutropenia. Further investigation is warranted to determine whether granulocyte donations can prevent the recurrence of IA in patients at risk of fungal infection. [ABSTRACT FROM AUTHOR]

Published
2003
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