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16 results on '"Oakeshott, Stephen"'

4. Cognitive Deficits in Transgenic and Knock-in HTT Mice Parallel those in Huntington's Disease

Author

Farrar, Andrew M., primary, Murphy, Carol A., additional, Paterson, Neil E., additional, Oakeshott, Stephen, additional, He, Dansha, additional, Alosio, William, additional, McConnell, Kristi, additional, Menalled, Liliana B., additional, Ramboz, Sylvie, additional, Park, Larry C., additional, Howland, David, additional, and Brunner, Dani, additional

Published
2014
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5. High-throughput automated phenotyping of two genetic mouse models of huntington's disease

Author

Balcı, Fuat (ORCID 0000-0003-3390-9352 & YÖK ID 51269), Oakeshott, Stephen; Shamy, Jul Lea T;. El-Khodor, Bassem Fouad; Filippov, Igor V.; Mushlin, Richard A.; Port, Russell G.; Connor, David; Paintdakhi, Ahmad; Menalled, Liliana B.; Ramboz, Sylvie; Howland, David S.; Kwak, Seung; Brunner, Dani, College of Social Sciences and Humanities, Department of Psychology, Balcı, Fuat (ORCID 0000-0003-3390-9352 & YÖK ID 51269), Oakeshott, Stephen; Shamy, Jul Lea T;. El-Khodor, Bassem Fouad; Filippov, Igor V.; Mushlin, Richard A.; Port, Russell G.; Connor, David; Paintdakhi, Ahmad; Menalled, Liliana B.; Ramboz, Sylvie; Howland, David S.; Kwak, Seung; Brunner, Dani, College of Social Sciences and Humanities, and Department of Psychology

Abstract

Phenotyping with traditional behavioral assays constitutes a major bottleneck in the primary screening, characterization, and validation of genetic mouse modelsof disease, leading to downstream delays in drug discovery efforts. We present a novel and comprehensive one-stop approach to phenotyping, the PhenoCube™. This system simultaneously captures the cognitive performance, motor activity, and circadian patterns of group-housed mice by use of home-cage operant conditioning modules (IntelliCage) and custom-built computer vision software. We evaluated two different mouse models of Huntington's Disease (HD), the R6/2 and the BACHD in the PhenoCube™ system. Our results demonstrated that this system can efficiently capture and track alterations in both cognitive performance and locomotor activity patterns associated with these disease models. This work extends our prior demonstration that PhenoCube™ can characterize circadian dysfunction in BACHD mice and shows that this system, with the experimental protocols used, is a sensitive and efficient tool for a first pass high-throughput screening of mouse disease models in general and mouse models of neurodegeneration in particular, NA

Published
2013

6. Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington’s Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits

Author

Kudwa, Andrea E., primary, Menalled, Liliana B., additional, Oakeshott, Stephen, additional, Murphy, Carol, additional, Mushlin, Richard, additional, Fitzpatrick, John, additional, Miller, Sam F., additional, McConnell, Kristi, additional, Port, Russell, additional, Torello, Justin, additional, Howland, David, additional, Ramboz, Sylvie, additional, and Brunner, Dani, additional

Published
2013
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7. High-Throughput Automated Phenotyping of Two Genetic Mouse Models of Huntington's Disease

Author

Balci, Fuat, primary, Shamy, Jul Lea, additional, El-Khodor, Bassem F., additional, Filippov, Igor, additional, Mushlin, Richard, additional, Port, Russell, additional, Connor, David, additional, Paintdakhi, Ahmad, additional, Menalled, Liliana, additional, Ramboz, Sylvie, additional, Howland, David, additional, Kwak, Seung, additional, Brunner, Dani, additional, and Oakeshott, Stephen, additional

Published
2013
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11. Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease

Author

Oakeshott, Stephen, primary, Balci, Fuat, additional, Filippov, Igor, additional, Murphy, Carol, additional, Port, Russell, additional, Connor, David, additional, Paintdakhi, Ahmad, additional, LeSauter, Joseph, additional, Menalled, Liliana, additional, Ramboz, Sylvie, additional, Kwak, Seung, additional, Howland, David, additional, Silver, Rae, additional, and Brunner, Dani, additional

Published
2011
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16. High-throughput automated phenotyping of two genetic mouse models of huntington's disease

Author

Liliana B. Menalled, Fuat Balcı, Stephen Oakeshott, Dani Brunner, David Howland, Jul Lea Shamy, David A. Connor, Russell G. Port, Sylvie Ramboz, Bassem F. El-Khodor, Ahmad Paintdakhi, Seung Kwak, Richard Mushlin, Igor Filippov, Balcı, Fuat (ORCID 0000-0003-3390-9352 & YÖK ID 51269), Oakeshott, Stephen, Shamy, Jul Lea T, El-Khodor, Bassem Fouad, Filippov, Igor V., Mushlin, Richard A., Port, Russell G., Connor, David, Paintdakhi, Ahmad, Menalled, Liliana B., Ramboz, Sylvie, Howland, David S., Kwak, Seung, Brunner, Dani, College of Social Sciences and Humanities, and Department of Psychology

Subjects
Drug discovery, Neurodegeneration, Medicine (miscellaneous), Throughput, Disease, Biology, medicine.disease, Bioinformatics, Locomotor activity, Huntington's disease, medicine, Motor activity, Animal experiment, Animal model, Article, Behavior, Controlled study, Female, Genotype, Habituation, High throughput sequencing, Huntington chorea, Licking, Light dark cycle, Light intensity, Locomotion, Motor performance, Mouse, Nerve degeneration, Nonhuman, Phenotype, Polymerase chain reaction, Reversal reaction, Scoring system, Neuroscience, Medicine, Circadian rhythm, Cognition, Primary screening, HD Models
Abstract

Phenotyping with traditional behavioral assays constitutes a major bottleneck in the primary screening, characterization, and validation of genetic mouse modelsof disease, leading to downstream delays in drug discovery efforts. We present a novel and comprehensive one-stop approach to phenotyping, the PhenoCube™. This system simultaneously captures the cognitive performance, motor activity, and circadian patterns of group-housed mice by use of home-cage operant conditioning modules (IntelliCage) and custom-built computer vision software. We evaluated two different mouse models of Huntington's Disease (HD), the R6/2 and the BACHD in the PhenoCube™ system. Our results demonstrated that this system can efficiently capture and track alterations in both cognitive performance and locomotor activity patterns associated with these disease models. This work extends our prior demonstration that PhenoCube™ can characterize circadian dysfunction in BACHD mice and shows that this system, with the experimental protocols used, is a sensitive and efficient tool for a first pass high-throughput screening of mouse disease models in general and mouse models of neurodegeneration in particular, NA

Published
2013

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