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Your search keyword '"OSTROWSKI, ROBERT P."' showing total 238 results
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238 results on '"OSTROWSKI, ROBERT P."'

2. Searching by Heterogeneous Agents

Author

Dereniowski, Dariusz, Kuszner, Łukasz, and Ostrowski, Robert

Subjects
Computer Science - Discrete Mathematics, Mathematics - Combinatorics, 68R10, 68W05, G.2.2
Abstract

In this work we introduce and study a pursuit-evasion game in which the search is performed by heterogeneous entities. We incorporate heterogeneity into the classical edge search problem by considering edge-labeled graphs: once a search strategy initially assigns labels to the searchers, each searcher can be only present on an edge of its own label. We prove that this problem is not monotone even for trees and we give instances in which the number of recontamination events is asymptotically quadratic in the tree size. Other negative results regard the NP-completeness of the monotone, and NP-hardness of an arbitrary (i.e., non-monotone) heterogeneous search in trees. These properties show that this problem behaves very differently from the classical edge search. On the other hand, if all edges of a particular label form a (connected) subtree of the input tree, then we show that optimal heterogeneous search strategy can be computed efficiently.

Published
2021

5. Subependymal Giant Cell Astrocytoma: The Molecular Landscape and Treatment Advances.

Author

Pucko, Emanuela, Sulejczak, Dorota, and Ostrowski, Robert P.

Subjects
GLIOMAS, ENZYME inhibitors, EARLY detection of cancer, TREATMENT effectiveness, TUBEROUS sclerosis, CELLULAR signal transduction, MAGNETIC resonance imaging, RNA, PHOSPHOTRANSFERASES, RAPAMYCIN, CELL receptors
Abstract

Simple Summary: Subependymal giant cell astrocytoma is a slow-growing brain tumor affecting children and young adults. Despite the characteristic molecular and clinical features, the severity of the disease varies from patient to patient, and, in addition, tumors in their early stages can be asymptomatic for a long time. Morbidity and mortality are due to the location of the tumor, which can obstruct the flow of cerebrospinal fluid, leading to progressive hydrocephalus and even death. The etiology and the response to treatment are still poorly understood due to the diversity of the background and the course of the disease. Therefore, this review aims to present and discuss the latest research on SEGA, its diagnosis, and treatment. Subependymal giant cell astrocytoma (SEGA) is most often found in patients with TSC (Tuberous Sclerosis Complex). Although it has been classified as a benign tumor, it may create a serious medical problem leading to grave consequences, including young patient demise. Surgery and chemotherapy belong to the gold standard of treatment. A broader pharmacological approach involves the ever-growing number of rapalogs and ATP-competitive inhibitors, as well as compounds targeting other kinases, such as dual PI3K/mTOR inhibitors and CK2 kinase inhibitors. Novel approaches may utilize noncoding RNA-based therapeutics and are extensively investigated to this end. The purpose of our review was to characterize SEGA and discuss the latest trends in the diagnosis and therapy of this disease. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Preconditioning for SAH

Author

Ostrowski, Robert P., Zhang, John H., Gidday, Jeffrey M., editor, Perez-Pinzon, Miguel A., editor, and Zhang, John H., editor

Published
2013
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20. Dexras1 Induces Dysdifferentiation of Oligodendrocytes and Myelin Injury by Inhibiting the cAMP-CREB Pathway after Subarachnoid Hemorrhage

Author

Xin, Yuanjun, primary, Chen, Jie, additional, Zhang, Hongxia, additional, Ostrowski, Robert P., additional, Liang, Yidan, additional, Zhao, Jun, additional, Xiang, Xiang, additional, Liang, Fuming, additional, Fu, Wenqiao, additional, Huang, Hao, additional, Wu, Xintong, additional, Su, Jun, additional, Deng, Jiewen, additional, and He, Zhaohui, additional

Published
2022
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