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Your search keyword '"ONORATO, M. E."' showing total 15 results
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15 results on '"ONORATO, M. E."'

4. ChemInform Abstract: Synthesis, Biotransformation and Stereochemistry of 6β‐ Sesquiterpene Lactones: Syntheses of 6β‐Artepaulin (‐)‐(III), 11, 13‐Dihydro‐6β‐tuberiferin (‐)‐(V), 5,15‐Dihydro‐6β‐oopodin (‐ )‐(VI), 4‐epi‐6β‐Vulgarin (‐)‐(VIII) and 6β‐Vulgarin (X).

Author

AMATE, Y., primary, BRETON, J. L., additional, GARCIA‐GRANADOS, A., additional, MARTINEZ, A., additional, ONORATO, M. E., additional, and SAENZ DE BURUAGA, A., additional

Published
1991
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15. New polyoxygenated ent-manoyl oxides obtained by biotransformation with filamentous fungi.

Author

García-Granados A, Liñán E, Martínez A, Onorato ME, and Arias JM

Subjects
Biotransformation, Colforsin chemistry, Colforsin isolation & purification, Colforsin metabolism, Culture Media chemistry, Fusarium chemistry, Magnetic Resonance Spectroscopy, Mucorales chemistry, Colforsin analogs & derivatives, Fusarium metabolism, Mucorales metabolism
Abstract

Incubation of methyl (13R)-ent-16-hydroxy-8 alpha,13-epoxylabd-14-en-18-oate [4] with Curvularia lunata yielded ent-1 beta-hydroxy [6] and ent-6 beta-hydroxy [7] derivatives, and that of methyl (13S)-ent-16-dihydroxy-8 alpha,13-epoxylabd-14-en-18-oate [5] with the same organism gave ent-11 beta-hydroxy [8], ent-6 beta-hydroxy [9], and ent-6 beta,11 beta-dihydroxy [10] derivatives. The incubation of substrates 4 and 5 with Fusarium moniliforme afforded ent-1 beta-hydroxy derivatives (6 and 14, respectively). Cunninghamella elegans produced ent-3 beta-hydroxy, ent-1 beta-hydroxy and ent-1 beta,3 beta-dihydroxy derivatives, and led to epoxidation of the double bond of the substrates. In addition, ent-3 beta,11 alpha-dihydroxy (as the acetoxy derivative 17) and ent-3 beta,11 beta-dihydroxy [12] derivatives were isolated from incubations of substrates 4 and 5, respectively. Compounds 7, 9-11, 14, 16-18, and 21 were characterized as new polyoxygenated ent-manoyl oxides.

Published
1995
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