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693 results on '"OHKUBO, KIMIE"'

2. Low alanine aminotransferase levels are independently associated with mortality risk in patients with atrial fibrillation

Author

Saito, Yuki, Okumura, Yasuo, Nagashima, Koichi, Fukamachi, Daisuke, Yokoyama, Katsuaki, Matsumoto, Naoya, Tachibana, Eizo, Kuronuma, Keiichiro, Oiwa, Koji, Matsumoto, Michiaki, Nishida, Toshihiko, Kojima, Toshiaki, Hanada, Shoji, Nomoto, Kazumiki, Sonoda, Kazumasa, Arima, Ken, Takahashi, Fumiyuki, Kotani, Tomobumi, Ohkubo, Kimie, Fukushima, Seiji, Itou, Satoru, Kondo, Kunio, Ando, Hideyuki, Ohno, Yasumi, Onikura, Motoyuki, and Hirayama, Atsushi

Published
2022
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3. Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls

Author

Walsh, Roddy, Lahrouchi, Najim, Tadros, Rafik, Kyndt, Florence, Glinge, Charlotte, Postema, Pieter G., Amin, Ahmad S., Nannenberg, Eline A., Ware, James S., Whiffin, Nicola, Mazzarotto, Francesco, Škorić-Milosavljević, Doris, Krijger, Christian, Arbelo, Elena, Babuty, Dominique, Barajas-Martinez, Hector, Beckmann, Britt M., Bézieau, Stéphane, Bos, J. Martijn, Breckpot, Jeroen, Campuzano, Oscar, Castelletti, Silvia, Celen, Candan, Clauss, Sebastian, Corveleyn, Anniek, Crotti, Lia, Dagradi, Federica, de Asmundis, Carlo, Denjoy, Isabelle, Dittmann, Sven, Ellinor, Patrick T., Ortuño, Cristina Gil, Giustetto, Carla, Gourraud, Jean-Baptiste, Hazeki, Daisuke, Horie, Minoru, Ishikawa, Taisuke, Itoh, Hideki, Kaneko, Yoshiaki, Kanters, Jørgen K., Kimoto, Hiroki, Kotta, Maria-Christina, Krapels, Ingrid P.C., Kurabayashi, Masahiko, Lazarte, Julieta, Leenhardt, Antoine, Loeys, Bart L., Lundin, Catarina, Makiyama, Takeru, Mansourati, Jacques, Martins, Raphaël P., Mazzanti, Andrea, Mörner, Stellan, Napolitano, Carlo, Ohkubo, Kimie, Papadakis, Michael, Rudic, Boris, Molina, Maria Sabater, Sacher, Frédéric, Sahin, Hatice, Sarquella-Brugada, Georgia, Sebastiano, Regina, Sharma, Sanjay, Sheppard, Mary N., Shimamoto, Keiko, Shoemaker, M.Benjamin, Stallmeyer, Birgit, Steinfurt, Johannes, Tanaka, Yuji, Tester, David J., Usuda, Keisuke, van der Zwaag, Paul A., Van Dooren, Sonia, Van Laer, Lut, Winbo, Annika, Winkel, Bo G., Yamagata, Kenichiro, Zumhagen, Sven, Volders, Paul G.A., Lubitz, Steven A., Antzelevitch, Charles, Platonov, Pyotr G., Odening, Katja E., Roden, Dan M., Roberts, Jason D., Skinner, Jonathan R., Tfelt-Hansen, Jacob, van den Berg, Maarten P., Olesen, Morten S., Lambiase, Pier D., Borggrefe, Martin, Hayashi, Kenshi, Rydberg, Annika, Nakajima, Tadashi, Yoshinaga, Masao, Saenen, Johan B., Kääb, Stefan, Brugada, Pedro, Robyns, Tomas, Giachino, Daniela F., Ackerman, Michael J., Brugada, Ramon, Brugada, Josep, Gimeno, Juan R., Hasdemir, Can, Guicheney, Pascale, Priori, Silvia G., Schulze-Bahr, Eric, Makita, Naomasa, Schwartz, Peter J., Shimizu, Wataru, Aiba, Takeshi, Schott, Jean-Jacques, Redon, Richard, Ohno, Seiko, Probst, Vincent, Arnaout, Alain Al, Amelot, Mathieu, Anselme, Frédéric, Billon, Olivier, Defaye, Pascal, Dupuis, Jean-Marc, Jesel, Laurence, Laurent, Gabriel, Maury, Philippe, Pasquie, Jean-Luc, Wiart, Francois, Behr, Elijah R., Barc, Julien, and Bezzina, Connie R.

Published
2021
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4. Association of patient satisfaction with direct oral anticoagulants and the clinical outcomes: Findings from the SAKURA AF registry

Author

Hori, Koichiro, Okumura, Yasuo, Koichi, Nagashima, Yokoyama, Katsuaki, Matsumoto, Naoya, Tachibana, Eizo, Kuronuma, Keiichiro, Oiwa, Koji, Matsumoto, Michiaki, Kojima, Toshiaki, Arima, Ken, Kotani, Tomobumi, Nomoto, Kazumiki, Ohkubo, Kimie, Fukushima, Seiji, Onikura, Motoyuki, Suzuki, Yasuko, Fujita, Masami, Ando, Hideyuki, Ishikawa, Norikazu, and Hirayama, Atsushi

Published
2020
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5. University hospitals, general hospitals, private clinics: Place-based differences in patient characteristics and outcomes of AF—A SAKURA AF Registry Substudy

Author

Kogawa, Rikitake, Okumura, Yasuo, Yokoyama, Katsuaki, Matsumoto, Naoya, Tachibana, Eizo, Kuronuma, Keiichiro, Oiwa, Koji, Nishida, Toshihiko, Matsumoto, Michiaki, Kojima, Toshiaki, Hanada, Shoji, Nomoto, Kazumiki, Sonoda, Kazumasa, Arima, Ken, Takahashi, Fumiyuki, Kotani, Tomobumi, Ohkubo, Kimie, Fukushima, Seiji, Itou, Satoru, Kondo, Kunio, Chiku, Masaaki, Ohno, Yasumi, Onikura, Motoyuki, and Hirayama, Atsushi

Published
2020
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8. Cardiac Emerinopathy: A Non-syndromic Nuclear Envelopathy with Increased Risk of Thromboembolic Stroke due to Progressive Atrial Standstill and Left Ventricular Non-compaction

Author

Ishikawa, Taisuke, Mishima, Hiroyuki, Barc, Julien, Takahashi, Masanori P., Hirono, Keiichi, Terada, Shigenori, Kowase, Shinya, Sato, Teruki, Mukai, Yasushi, Yui, Yoshiaki, Ohkubo, Kimie, Kimoto, Hiroki, Watanabe, Hiroyuki, Hata, Yukiko, Aiba, Takeshi, Ohno, Seiko, Chishaki, Akiko, Shimizu, Wataru, Horie, Minoru, Ichida, Fukiko, Nogami, Akihiko, Yoshiura, Koh-Ichiro, Schott, Jean-Jacques, and Makita, Naomasa

Published
2020
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10. Characteristics of tissue temperature during ablation with THERMOCOOL SMARTTOUCH SF versus TactiCath versus QDOT MICRO catheters (Qmode and Qmode+): An in vivo porcine study

Author

Otsuka, Naoto, primary, Okumura, Yasuo, additional, Kuorkawa, Sayaka, additional, Nagashima, Koichi, additional, Wakamatsu, Yuji, additional, Hayashida, Satoshi, additional, Ohkubo, Kimie, additional, Nakai, Toshiko, additional, Takahashi, Rie, additional, and Taniguchi, Yoshiki, additional

Published
2023
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21. Characteristics of tissue temperature during ablation with THERMOCOOL SMARTTOUCH SF versus TactiCath versus QDOT MICRO catheters (Qmode and Qmode+): An in vivo porcine study.

Author

Otsuka, Naoto, Okumura, Yasuo, Kuorkawa, Sayaka, Nagashima, Koichi, Wakamatsu, Yuji, Hayashida, Satoshi, Ohkubo, Kimie, Nakai, Toshiko, Takahashi, Rie, and Taniguchi, Yoshiki

Subjects
ESOPHAGEAL injuries, ATRIAL fibrillation diagnosis, HEAT, VENA cava superior, IN vivo studies, ANIMAL experimentation, ATRIAL fibrillation, CATHETER ablation, SWINE, PEARSON correlation (Statistics), CHI-squared test, DESCRIPTIVE statistics, RESEARCH funding, PULMONARY veins, RECEIVER operating characteristic curves, DATA analysis software, CATHETERS, PHRENIC nerve
Abstract

Introduction: High‐power short‐duration (HPSD) ablation at 50 W, guided by ablation index (AI) or lesion size index (LSI), and a 90 W/4 s very HSPD (vHPSD) setting are available for atrial fibrillation (AF) treatment. Yet, tissue temperatures during ablation with different catheters around venoatrial junction and collateral tissues remain unclear. Methods: In this porcine study, we surgically implanted thermocouples on the epicardium near the superior vena cava (SVC), right pulmonary vein, and esophagus close to the inferior vena cava. We then compared tissue temperatures during 50W‐HPSD guided by AI 400 or LSI 5.0, and 90 W/4 s‐vHPSD ablation using THERMOCOOL SMARTTOUCH SF (STSF), TactiCath ablation catheter, sensor enabled (TacthCath), and QDOT MICRO (Qmode and Qmode+ settings) catheters. Results: STSF produced the highest maximum tissue temperature (Tmax), followed by TactiCath, and QDOT MICRO in Qmode and Qmode+ (62.7 ± 12.5°C, 58.0 ± 10.1°C, 50.0 ± 12.1°C, and 49.2 ± 8.4°C, respectively; p =.005), achieving effective transmural lesions. Time to lethal tissue temperature ≥50°C (t−T ≥ 50°C) was fastest in Qmode+, followed by TacthCath, STSF, and Qmode (4.3 ± 2.5, 6.4 ± 1.9, 7.1 ± 2.8, and 7.7 ± 3.1 s, respectively; p <.001). The catheter tip‐to‐thermocouple distance for lethal temperature (indicating lesion depth) from receiver operating characteristic curve analysis was deepest in STSF at 5.2 mm, followed by Qmode at 4.3 mm, Qmode+ at 3.1 mm, and TactiCath at 2.8 mm. Ablation at the SVC near the phrenic nerve led to sudden injury at t−T ≥ 50°C in all four settings. The esophageal adventitia injury was least deep with Qmode+ ablation (0.4 ± 0.1 vs. 0.8 ± 0.4 mm for Qmode, 0.9 ± 0.3 mm for TactiCath, and 1.1 ± 0.5 mm for STSF, respectively; p =.005), correlating with Tmax. Conclusion: This study revealed distinct tissue temperature patterns during HSPD and vHPSD ablations with the three catheters, affecting lesion effectiveness and collateral damage based on Tmax and/or t−T ≥ 50°C. These findings provide key insights into the safety and efficacy of AF ablation with these four settings. [ABSTRACT FROM AUTHOR]

Published
2024
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27. In vivo tissue temperatures during 90 W/4 sec‐very high power‐short‐duration (vHPSD) ablation versus ablation index‐guided 50 W‐HPSD ablation: A porcine study

Author

Otsuka, Naoto, primary, Okumura, Yasuo, additional, Kuorkawa, Sayaka, additional, Nagashima, Koichi, additional, Wakamatsu, Yuji, additional, Hayashida, Satoshi, additional, Ohkubo, Kimie, additional, Nakai, Toshiko, additional, Hao, Hiroyuki, additional, Takahashi, Rie, additional, and Taniguchi, Yoshiki, additional

Published
2022
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39. Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers

Author

Nishiuchi, Suguru, Makiyama, Takeru, Aiba, Takeshi, Nakajima, Kenzaburo, Hirose, Sayako, Kohjitani, Hirohiko, Yamamoto, Yuta, Harita, Takeshi, Hayano, Mamoru, Wuriyanghai, Yimin, Chen, Jiarong, Sasaki, Kenichi, Yagihara, Nobue, Ishikawa, Taisuke, Onoue, Kenji, Murakoshi, Nobuyuki, Watanabe, Ichiro, Ohkubo, Kimie, Watanabe, Hiroshi, Ohno, Seiko, Doi, Takahiro, Shizuta, Satoshi, Minamino, Tohru, Saito, Yoshihiko, Oginosawa, Yasushi, Nogami, Akihiko, Aonuma, Kazutaka, Kusano, Kengo, Makita, Naomasa, Shimizu, Wataru, Horie, Minoru, and Kimura, Takeshi

Published
2017
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40. Abstract 21144: Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers in Japan

Author

Nishiuchi, Suguru, Aiba, Takeshi, Makiyama, Takeru, Nakajima, Kenzaburo, Yagihara, Nobue, Ishikawa, Taisuke, Onoue, Kenji, Murakoshi, Nobuyuki, Watanabe, Ichiro, Ohkubo, Kimie, Watanabe, Hiroshi, Ohno, Seiko, Doi, Takahiro, Shizuta, Satoshi, Minamino, Tohru, Saito, Yoshihiko, Oginosawa, Yasushi, Nogami, Akihiko, Aonuma, Kazutaka, Kusano, Kengo, Makita, Naomasa, Shimizu, Wataru, Horie, Minoru, and Kimura, Takeshi

Published
2017

45. In vivo tissue temperatures during 90 W/4 sec‐very high power‐short‐duration (vHPSD) ablation versus ablation index‐guided 50 W‐HPSD ablation: A porcine study.

Author

Otsuka, Naoto, Okumura, Yasuo, Kuorkawa, Sayaka, Nagashima, Koichi, Wakamatsu, Yuji, Hayashida, Satoshi, Ohkubo, Kimie, Nakai, Toshiko, Hao, Hiroyuki, Takahashi, Rie, and Taniguchi, Yoshiki

Subjects
ESOPHAGEAL injuries, ESOPHAGEAL surgery, ATRIAL fibrillation diagnosis, BODY temperature, IN vivo studies, VENA cava superior, ANIMAL experimentation, ATRIAL fibrillation, CATHETER ablation, SWINE, THORACOTOMY, DESCRIPTIVE statistics, PULMONARY veins
Abstract

Introduction: Neither the actual in vivo tissue temperatures reached with 90 W/4 s‐very high‐power short‐duration (vHPSD) ablation for atrial fibrillation nor the safety and efficacy profile have been fully elucidated. Methods: We conducted a porcine study (n = 15) in which, after right thoracotomy, we implanted 6–8 thermocouples epicardially in the superior vena cava, right pulmonary vein, and esophagus close to the inferior vena cava. We compared tissue temperatures close to a QDOT MICRO catheter, between during 90 W/4 s‐vHPSD ablation during ablation index (AI: target 400)‐guided 50 W‐HPSD ablation, both targeting a contact force of 8–15 g. Results: Maximum tissue temperature reached during 90 W/4 s‐vHPSD ablation did not differ significantly from that during 50 W‐HPSD ablation (49.2 ± 8.4°C vs. 50.0 ± 12.1°C; p =.69) and correlated inversely with distance between the catheter tip and the thermocouple, regardless of the power settings (r = −0.52 and r = −0.37). Lethal temperature (≥50°C) was best predicted at a catheter tip‐to‐thermocouple distance cut‐point of 3.13 and 4.27 mm, respectively. All lesions produced by 90 W/4 s‐vHPSD or 50 W‐HPSD ablation were transmural. Although there was no difference in the esophageal injury rate (50% vs. 66%, p =.80), the thermal lesion was significantly shallower with 90 W/4 s‐vHPSD ablation than with 50W‐HPSD ablation (381.3 ± 127.3 vs. 820.0 ± 426.1 μm from the esophageal adventitia; p =.039). Conclusion: Actual tissue temperatures reached with 90 W/4 s‐vHPSD ablation appear similar to those with AI‐guided 50 W‐HPSD ablation, with the distance between the catheter tip and target tissue being shorter for the former. Although both ablation settings may create transmural lesions in thin atrial tissues, any resulting esophageal thermal lesions appear shallower with 90 W/4 s‐vHPSD ablation. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Actual tissue temperature during ablation index‐guided high‐power short‐duration ablation versus standard ablation: Implications in terms of the efficacy and safety of atrial fibrillation ablation

Author

Otsuka, Naoto, primary, Okumura, Yasuo, additional, Kuorkawa, Sayaka, additional, Nagashima, Koichi, additional, Wakamatsu, Yuji, additional, Hayashida, Satoshi, additional, Ohkubo, Kimie, additional, Nakai, Toshiko, additional, Hao, Hiroyuki, additional, Takahashi, Rie, additional, and Taniguchi, Yoshiki, additional

Published
2021
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50. In vivo tissue temperature during lesion size index‐guided 50W ablation versus 30W ablation: A porcine study.

Author

Otsuka, Naoto, Okumura, Yasuo, Kuorkawa, Sayaka, Nagashima, Koichi, Wakamatsu, Yuji, Hayashida, Satoshi, Ohkubo, Kimie, Nakai, Toshiko, Hao, Hiroyuki, Takahashi, Rie, and Taniguchi, Yoshiki

Subjects
TEMPERATURE, IN vivo studies, VENA cava superior, STAINS & staining (Microscopy), ATRIAL fibrillation, CATHETER ablation, THORACOTOMY, FISHER exact test, T-test (Statistics), TISSUES, DESCRIPTIVE statistics, PULMONARY veins, VENA cava inferior, RECEIVER operating characteristic curves, DATA analysis software
Abstract

Background: Neither the actual in vivo tissue temperatures reached with lesion size index (LSI)‐guided high‐power short‐duration (HPSD) ablation for atrial fibrillation nor the safety profile has been elucidated. Methods: We conducted a porcine study (n = 7) in which, after right thoracotomy, we implanted 6–8 thermocouples epicardially in the superior vena cava, right pulmonary vein, and esophagus close to the inferior vena cava. We compared tissue temperatures reached during 50 W‐HPSD ablation with those reached during standard (30 W) ablation, both targeting an LSI of 5.0 (5–15 g contact force). Results: Tmax (maximum tissue temperature when the thermocouple was located ≤5 mm from the catheter tip) reached during HPSD ablation was modestly higher than that reached during standard ablation (58.0 ± 10.1°C vs. 53.6 ± 9.2°C; p =.14) and peak tissue temperature correlated inversely with the distance between the catheter tip and the thermocouple, regardless of the power settings (HPSD: r = −0.63; standard: r = −0.66). Lethal temperature (≥50°C) reached 6.3 ± 1.8 s and 16.9 ± 16.1 s after the start of HPSD and standard ablation, respectively (p =.002), and it was best predicted at a catheter tip‐to‐thermocouple distance cut point of 2.8 and 5.3 mm, respectively. All lesions produced by HPSD ablation and by standard ablation were transmural. There was no difference between HPSD ablation and standard ablation in the esophageal injury rate (70% vs. 75%, p =.81), but the maximum distance from the esophageal adventitia to the injury site tended to be shorter (0.94 ± 0.29 mm vs. 1.40 ± 0.57 mm, respectively; p =.09). Conclusions: Actual tissue temperatures reached with LSI‐guided HPSD ablation appear to be modestly higher, with a shorter distance between the catheter tip and thermocouple achieving lethal temperature, than those reached with standard ablation. HPSD ablation lasting <6 s may help minimize lethal thermal injury to the esophagus lying at a close distance. [ABSTRACT FROM AUTHOR]

Published
2023
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