1. Parieto-occipital sulcus widening differentiates posterior cortical atrophy from typical Alzheimer disease
- Author
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Tiziana Carandini, Elio Scarpini, Matteo Mercurio, Annalisa Colombi, Andrea Arighi, Paola Basilico, Elisa Scola, Luca Sacchi, Marta Scarioni, Fabio Triulzi, Daniela Galimberti, Giorgio G. Fumagalli, Giorgio Conte, Anna M. Pietroboni, Neurology, and Amsterdam Neuroscience - Neurodegeneration
- Subjects
Visual rating scale ,genetic structures ,FDG, fluorodeoxyglucose ,CON, Controls ,Precuneus ,Audiology ,PCA, Posterior cortical atrophy ,lcsh:RC346-429 ,PA, Posterior scale ,PET, Positron emission tomography ,LBD, Lewy Body Dementia ,0302 clinical medicine ,Gray Matter ,Cerebral Cortex ,VOSP, Visual object and space perception test ,AUC, Area under the ROC Curve ,05 social sciences ,Regular Article ,MTA, Medial temporal scale ,Sulcus ,Magnetic Resonance Imaging ,MMSE, Mini Mental State Examination ,medicine.anatomical_structure ,Neurology ,lcsh:R858-859.7 ,Occipital Lobe ,Parieto-occipital sulcus ,Alzheimer Disease ,Differential Diagnosis ,Posterior Cortical Atrophy ,Voxel based morphometry ,medicine.medical_specialty ,MNI, Montreal Neurological Institute ,Cognitive Neuroscience ,Grey matter ,lcsh:Computer applications to medicine. Medical informatics ,050105 experimental psychology ,03 medical and health sciences ,Atrophy ,medicine ,OF, Orbito-Frontal scale ,Humans ,0501 psychology and cognitive sciences ,Radiology, Nuclear Medicine and imaging ,AT, Anterior temporal scale ,PCS, Posterior cingulate sulcus scale ,WM, white matter ,lcsh:Neurology. Diseases of the nervous system ,FEW, Family wise error ,PRE, Precuneus scale ,AD, Alzheimer disease ,business.industry ,POS, Parieto-occipital sulcus scale ,Posterior cortical atrophy ,GM, grey matter ,Voxel-based morphometry ,medicine.disease ,Posterior cingulate ,VBM, Voxel Based Morphometry ,Neurology (clinical) ,business ,MRI, magnetic resonance imaging ,CSF, Cerebrospinal Fluid ,030217 neurology & neurosurgery - Abstract
Highlights • Parieto-occipital sulcus visual rating scale can distinguish PCA from typical AD. • Visual rating scales have been validated using VBM and Brainvisa Morphologist. • Visual rating score reflects sulcal widening rather than grey matter reduction., Objectives Posterior Cortical Atrophy (PCA) is an atypical presentation of Alzheimer disease (AD) characterized by atrophy of posterior brain regions. This pattern of atrophy is usually evaluated with Koedam visual rating scale, a score developed to enable visual assessment of parietal atrophy on magnetic resonance imaging (MRI). However, Koedam scale is complex to assess and its utility in the differential diagnosis between PCA and typical AD has not been demonstrated yet. The aim of this study is therefore to spot a simple and reliable MRI element able to differentiate between PCA and typical AD using visual rating scales. Methods 15 patients who presented with progressive complex visual disorders and predominant occipitoparietal hypometabolism on PET-FDG were selected from our centre and compared with 30 typical AD patients and 15 healthy subjects. We used previously validated visual rating scales including Koedam scale, which we divided into three major components: posterior cingulate, precuneus and parieto-occipital. Subsequently we validated the results using the automated software Brainvisa Morphologist and Voxel Based Morphometry (VBM). Results Patients with PCA, compared to typical AD, showed higher widening of the parieto-occipital sulcus, assessed both with visual rating scales and Brainvisa. In the corresponding areas, the VBM analysis showed an inverse correlation between the results obtained from the visual evaluation scales with the volume of the grey matter and a direct correlation between the same results with the cerebrospinal fluid volume. Conclusions A visually based rating scale for parieto-occipital sulcus can distinguish Posterior Cortical Atrophy from typical Alzheimer disease.
- Published
- 2020
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