163 results on '"O. Mohamad"'
Search Results
2. Estimation of Some Genetic Parameters, Correlation and Heritability in Various Maize Traits
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Mohamed A. Hussain and Mohamed O. Mohamad
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Genetic Parameters ,Heritability ,Maize Traits ,Correlation ,Science - Abstract
The study was carried out using ten maize hybrids in spring 2015 and 2016 were planted at the field of Agriculture College, University of Duhok. All treatments arranged in Randomized Complete Block Design (RCBD) with three replications to determine the heritability, genetic advance, correlation and genetic parameters govering the inheritance of grain yield and related agronomic traits. The result showed significant difference among hybrids for studied traits in spring 2015 and 2016 and also the results revealed that hybrids and seasons interaction had a significant difference for all traits. The season’s spring 2015 was superior than spring 2016 in leaf area, days to 75% tasseling and silking, yield and its components. The hybrid (OH40 xIK8) was superior in No. of rows ear-1, No. of kernels row-1,300 kernel weight and kernel yield plant1. All studied traits recorded higher value of heritability, high genetic advance coupled with heritability was observed in leaf area and kernel yield plant-1, thus selection based on these traits will be effective in maize breeding program. Grain yield was positively correlated with leaf area and 300 kernel weight, also No. of row ear-1 exhibited positive correlation coefficient with leaf area, 300-kernell weight and kernel yield plant-1.
- Published
- 2017
- Full Text
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3. Preliminary study of sago fine waste as a sand replacement material for cement brick
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Izaan, I Hadi, Hani, A. Suraya, A. W., Norhayati, O., Mohamad Hairi, J., Zalipah, A. H., Noor Azlina, S., Norhafizah, Mia Wimala, Mia Wimala, Izaan, I Hadi, Hani, A. Suraya, A. W., Norhayati, O., Mohamad Hairi, J., Zalipah, A. H., Noor Azlina, S., Norhafizah, and Mia Wimala, Mia Wimala
- Abstract
This paper presented a preliminary results of utilization sago fine waste as a sand replacement material for cement bricks. Sago waste is a by-product of the extraction of sago starch. Usually, the bark is not utilized for other products and being dumped directly into the rivers or left for natural degradation. About 32,250 tons of sago bark waste annually. Sand however usually obtained by using machinery at the riverbank which greatly contribute to damaging the ecosystem of the river and contributing to global warming. For environmental protection and sustainable development, extensive research has been conducted on the production of bricks from waste materials. The replacement percentage of SFW are 0%, 5%, 10%, 15%, 20% and 25% with water content of 50% and 60%. Density, water absorption and compressive strength are the properties that have been investigated. From the results obtained, both density and compressive strength are decreasing as the percentages of SFW increasing. On the other hand, from the data of water absorption it was found that the percentage of water absorption of brick was increased correspond to the increasing percentages of the SFW. Based on the findings, the optimum brick properties are SFW1W0.6 with the strength 5.18 MPa that can be used as non-load bearing bricks and the optimum percentage of water absorption is at 13.33%. From this study, it was found that the replacement of sand by SFW give a significant impact on density, strength, and water absorption performance of concrete brick.
- Published
- 2022
4. Inheritance of kernel elongation in F2 rice populations crossed between Indian rice basmati 370 and selected Malaysian rice varieties
- Author
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A.G. Mohamad Bahagia, O. Mohamad, A Shamsiah, A Nur Suraya, A Asmah, and A A Noorshilawati
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Inheritance (object-oriented programming) ,Kernel (statistics) ,Statistics ,food and beverages ,Elongation ,Food Science ,Mathematics - Abstract
The speciality rice variety such as Basmati and Jasmine maybe not be very suitable to plant under the Malaysian climate because the growth may be influenced by the changes in the environmental conditions causing the changes of its physical and chemical characters and results in low yield. Thus, an attempt was made through a hybridisation program among selected Malaysian rice varieties consist of MRQ50, MRQ74, MRQ76, MR219, Mahsuri Mutant, and Mahsuri Mutant 98 with Indian traditional rice, Basmati 370 with the main objectives, to compare the kernel elongation ratio of each cross and to determine the potential and suitable combination among crosses rice for further evaluation program. The results of the study indicated that among parental lines, Basmati 370 posed the highest elongation ratio 2.00 which revealed its speciality elongation trait of cooked rice. A comparison between crosses, rice cross between Basmati 370 and Mahsuri Mutant 98 showed the highest elongation ratio with the value 2.12 and the lowest elongation ratio of about 1.96 was found in rice cross between Basmati 370 and MR219. However, all hybridised rice poses a value of elongation ratio more than 1.6 which is considered good kernel elongation. The segregation pattern of all crosses also posed a ratio 3:1 whereas three is low elongation and one is high elongation which demonstrated the Mendelian inheritance of monogenic cross. The results obtained from this study could contribute to the existing literature on speciality rice production in Malaysia and beneficial for future rice quality improvement program.
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- 2020
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5. Peer Review #2 of 'BengSentiLex and BengSwearLex: creating lexicons for sentiment analysis and profanity detection in low-resource Bengali language (v0.1)'
- Author
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O Mohamad Beigi
- Subjects
Bengali ,Computer science ,business.industry ,Low resource ,Sentiment analysis ,language ,Artificial intelligence ,business ,computer.software_genre ,computer ,Natural language processing ,language.human_language - Published
- 2021
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6. Prevalence of glucose-6-phosphate dehydrogenase deficiency (G6PDd), CareStart qualitative rapid diagnostic test performance, and genetic variants in two malaria-endemic areas in Sudan
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Leena Omereltinai, Muzamil Mahdi Abdel Hamid, Abdelrahim O. Mohamad, Sara B. Eltom, Nouh S. Mohamed, Musab M. Ali Albsheer, Andrew A. Lover, and Mohamed S. Muneer
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Male ,Plasmodium ,Primaquine ,Heredity ,Tafenoquine ,Plasmodium vivax ,RC955-962 ,Homozygosity ,Geographical Locations ,Sudan ,chemistry.chemical_compound ,Medical Conditions ,Spectrum Analysis Techniques ,Arctic medicine. Tropical medicine ,Medicine and Health Sciences ,Glucose-6-Phosphate Dehydrogenase Deficiency ,Rapid diagnostic test ,biology ,Drugs ,Anemia ,Hematology ,Middle Aged ,Genetic Mapping ,Infectious Diseases ,Spectrophotometry ,Point-of-Care Testing ,Population study ,Female ,Restriction fragment length polymorphism ,Public aspects of medicine ,RA1-1270 ,medicine.drug ,Research Article ,Adult ,medicine.medical_specialty ,Adolescent ,Genotype ,Variant Genotypes ,Glucosephosphate Dehydrogenase ,Research and Analysis Methods ,Young Adult ,Internal medicine ,Parasite Groups ,parasitic diseases ,medicine ,Parasitic Diseases ,Genetics ,Humans ,Pharmacology ,business.industry ,Diagnostic Tests, Routine ,Public Health, Environmental and Occupational Health ,Hemolytic Anemia ,Biology and Life Sciences ,Genetic Variation ,medicine.disease ,biology.organism_classification ,Tropical Diseases ,Malaria ,Cross-Sectional Studies ,Glucosephosphate Dehydrogenase Deficiency ,chemistry ,People and Places ,Africa ,Parasitology ,business ,Apicomplexa ,Glucose-6-phosphate dehydrogenase deficiency - Abstract
Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is the most common enzymopathy globally, and deficient individuals may experience severe hemolysis following treatment with 8-aminoquinolines. With increasing evidence of Plasmodium vivax infections throughout sub-Saharan Africa, there is a pressing need for population-level data at on the prevalence of G6PDd. Such evidence-based data will guide the expansion of primaquine and potentially tafenoquine for radical cure of P. vivax infections. This study aimed to quantify G6PDd prevalence in two geographically distinct areas in Sudan, and evaluating the performance of a qualitative CareStart rapid diagnostic test as a point-of-care test. Blood samples were analyzed from 491 unrelated healthy persons in two malaria-endemic sites in eastern and central Sudan. A pre-structured questionnaire was used which included demographic data, risk factors and treatment history. G6PD levels were measured using spectrophotometry (SPINREACT) and first-generation qualitative CareStart rapid tests. G6PD variants (202 G>A; 376 A>G) were determined by PCR/RFLP, with a subset confirmed by Sanger sequencing. The prevalence of G6PDd by spectrophotometry was 5.5% (27/491; at 30% of adjusted male median, AMM); 27.3% (134/491; at 70% of AMM); and 13.1% (64/490) by qualitative CareStart rapid diagnostic test. The first-generation CareStart rapid diagnostic test had an overall sensitivity of 81.5% (95%CI: 61.9 to 93.7) and negative predictive value of 98.8% (97.3 to 99.6). All persons genotyped across both study sites were wild type for the G6PD G202 variant. For G6PD A376G all participants in New Halfa had wild type AA (100%), while in Khartoum the AA polymorphism was found in 90.7%; AG in 2.5%; and GG in 6.8%. Phenotypic G6PD B was detected in 100% of tested participants in New Halfa while in Khartoum, the phenotypes observed were B (96.2%), A (2.8%), and AB (1%). The African A- phenotype was not detected in this study population. Overall, G6PDd prevalence in Sudan is low-to-moderate but highly heterogeneous. Point-of-care testing with the qualitative CareStart rapid diagnostic test demonstrated moderate performance with moderate sensitivity and specificity but high negative predicative value. The two sites harbored primarily the African B phenotype. A country-wide survey is recommended to understand GP6PD deficiencies more comprehensively in Sudan., Author summary Malaria is caused by five species of parasites; of these Plasmodium falciparum and P. vivax cause the majority of global morbidity and mortality. Plasmodium vivax infection is an emerging public health problem in sub-Saharan Africa, including Sudan. Primaquine and other 8-aminoquinolines including tafenoquine are the primary treatments to target the silent liver stage (hypnozoites) in P. vivax infections. However, these regimens can cause severe intravascular hemolysis in patients suffering from glucose-6-phosphate dehydrogenase deficiency (G6PDd). To support safe and efficacious use of primaquine, and potentially tafenoquine in Sudan, this study aimed to estimate the prevalence of G6PDd across two sites in Sudan using spectrophotometry and a qualitative CareStart rapid diagnostic test. Subsequent genetic analysis by PCR/RFLP and sequencing of G6PD genetic variants was performed. This survey found an overall prevalence was 5.5% (27/491; 30% of adjusted male median, AMM), and 27.3% (134/491; 70% of AMM) and 13.1% (64/490) by qualitative CareStart rapid diagnostic test. Important differences in distribution of genetic variants of G6PD were found across the two sites, and the African A- was not observed. In univariate analysis a few parameters showed significant association with G6PD deficiency. In conclusion the prevalence of G6PDd was low to moderate but heterogonous, and the first-generation qualitative CareStart rapid diagnostic test showed moderate performance in both males and females.
- Published
- 2021
7. Prostate Cancer Risk Stratification in NRG Oncology Phase III Randomized Trials Using Multi-Modal Deep Learning with Digital Histopathology
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J.D. Tward, J. Zhang, A. Esteva, O. Mohamad, D. van der Wal, J. Simko, S. DeVries, H.C. Huang, E.M. Schaeffer, T.M. Morgan, H.A. Campbell, J. Monson, J. Wallace, M.J. Ferguson, J.P. Bahary, H.M. Sandler, D.E. Spratt, J. Rodgers, F.Y. Feng, and P.T. Tran
- Subjects
Cancer Research ,Radiation ,Oncology ,Radiology, Nuclear Medicine and imaging - Published
- 2022
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8. The Environmental Impact of a Hybrid Medical Conference: Reduced Carbon Emissions of ASTRO's Digital XP 2021 Conference Model
- Author
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K. Lichter, S. Demeulenaere, T. Drew, E. Wong, S. Grover, K. Gundling, O. Mohamad, and L. Singer
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Cancer Research ,Radiation ,Oncology ,Radiology, Nuclear Medicine and imaging - Published
- 2022
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9. Machine Learning for the Prediction of Distant Metastases Following Postprostatectomy Salvage Radiation Therapy
- Author
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A. Sabbagh, D. Tilki, J. Feng, J.C. Hong, M.H. Chen, J. Wu, H. Huland, M. Graefen, T. Wiegel, D. Böhmer, S. Washington, J. Cowan, M.R. Cooperberg, F.Y. Feng, P. Carroll, B. Trock, A.W. Partin, A.V. DAmico, and O. Mohamad
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Cancer Research ,Radiation ,Oncology ,Radiology, Nuclear Medicine and imaging - Published
- 2022
- Full Text
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10. Preliminary Study of Sago Fine Waste as a Sand Replacement Material for Cement Brick
- Author
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I Hadi Izaan, A Suraya Hani, A.W. Norhayati, O Mohamad Hairi, J Zalipah, AH Noor Azlina, S Norhafizah, and Mia Wimala
- Abstract
This paper presented a preliminary results of utilization sago fine waste as a sand replacement material for cement bricks. Sago waste is a by-product of the extraction of sago starch. Usually, the bark is not utilized for other products and being dumped directly into the rivers or left for natural degradation. About 32,250 tons of sago bark waste annually. Sand however usually obtained by using machinery at the riverbank which greatly contribute to damaging the ecosystem of the river and contributing to global warming. For environmental protection and sustainable development, extensive research has been conducted on the production of bricks from waste materials. The replacement percentage of SFW are 0%, 5%, 10%, 15%, 20% and 25% with water content of 50% and 60%. Density, water absorption and compressive strength are the properties that have been investigated. From the results obtained, both density and compressive strength are decreasing as the percentages of SFW increasing. On the other hand, from the data of water absorption it was found that the percentage of water absorption of brick was increased correspond to the increasing percentages of the SFW. Based on the findings, the optimum brick properties are SFW1W0.6 with the strength 5.18 MPa that can be used as non-load bearing bricks and the optimum percentage of water absorption is at 13.33%. From this study, it was found that the replacement of sand by SFW give a significant impact on density, strength, and water absorption performance of concrete brick.
- Published
- 2022
- Full Text
- View/download PDF
11. Prevalence of hydatid cyst in human and animals in Sulaimaniya city and Saedsadq distract
- Author
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Mohamad O. Mohamad, Lazem H. Al-taie, and Hersh A. Amin
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Ecchinococcosis, hydatidosis, ELISA, IHA, Sulaimaniya ,Medicine ,Medicine (General) ,R5-920 - Abstract
Background: Hydatid disease is widespread and considered endemic in the Middle East and the Mediterranean, Iraq is one of the countries with a high endemicity of this disease. Objectives: The aim of this study is to diagnose hydatidosis and to identify the prevalence in human and animals in two different areas Sulaimaniya governorate which include Sulaimaniya city and Saedsadq district., Methods: Seroepidemiological survey was conducted by using enzyme-linked immunosorbent assay (ELISA) and Indirect Haemagglutination IHA to detect anti Echinococcus granulosus antibody in random blood samples (536) of different sex, ages, and occupation out patients, in Sulaimaniya and Saedsadq. In the animal study inspection and examination of the internal organs (liver, lungs, spleen and heart) Results: The Seropositivty in Saedsadq was higher( 3.7% )than in Sulaimaniya( 2.5%), and in female (2.8%, 6.4%) were higher than in male (1.6%, 1.2%) respectively both in Sulaimaniya and Saedsadq. In animal study results revealed that In Sulaimaniya infection rates were (1.5% of sheep, 0.5% of goats and 0.2% of cattle), less than in Saedsadq (7.5%, 2.8% and 1.7%) respectively, Conclusion: The seropositive was higher in Saedsadq than Sulaimaniya , and higher among females than males in all age groups. The prevalence and fertility of hydatid cysts in sheep is higher than goat and cattle, sheep. Liver is the main involved organ.
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- 2008
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12. The Compressive Strength and Water Absorption of Railway’s Concrete Sleepers Containing Palm Oil Fuel Ash (POFA) as a Cement Replacement Material
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A H Noor Azlina, A Suraya Hani, A S Nurfarhanna, J Zalipah, S Norhafizah, A Anizahyati, and O Mohamad Hairi
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Cement ,Materials science ,Absorption of water ,Compressive strength ,Palm oil ,Composite material - Abstract
Railway’s concrete sleepers demand high consumption of cement which generates higher energy assumption and carbon emission. Meanwhile, in Malaysia, around 100 tonnes of palm oil fuel ash (POFA) were disposed of in the landfill, which endangering environmental health. However, this POFA have pozzolanic properties that can be employed as cementitious material. Therefore, this study aimed to produce a sustainable concrete sleeper by using POFA as a cement replacement material focusing on the compressive strength and water absorption performance. Concrete samples with a strength grade of 55MPa and w/c of 0.35 were prepared with three design mixes containing 0% (control), 20%(POFA20), and 40%(POFA40) of POFA. For the compressive strength test, a compression machine was used. Meanwhile, the water absorption was measured at atmospheric pressure. Both tests were conducted at 7 and 28 days of curing age. The results show that as the curing age increases, their water absorption and compressive strength improves, indicating a pozzolanic reaction. In terms of POFA content, the water absorption increases by 14% and 54% for POFA20 and POFA40, respectively. Meanwhile, the compressive strength reduced by 39% for POFA20 and 67% for POFA40. Since POFA20 meets the standards, it is however applicable in slab tracks.
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- 2021
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13. EFFECTS OF STEEPING CONDITIONS (TEMPERATURE, PARTICLE SIZE AND DURATION) USING WATER ON STEVIOL GLYCOSIDES CONTENT FROM Stevia rebaudiana AND SENSORY EVALUATION OF OPTIMISED SAMPLE
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AHNur Sabreena, O Mohamad, YNor Azma, and A Asmah
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chemistry.chemical_classification ,chemistry.chemical_compound ,Stevia rebaudiana ,chemistry ,Duration (music) ,Sample (material) ,Glycoside ,Steviol ,Food science ,Particle size ,Steeping - Published
- 2017
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14. ANALYSIS OF STEVIOL GLYCOSIDES FROM Stevia rebaudiana BY USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY AND REFRACTOMETER, HENCE THE CORRELATION BETWEEN BOTH ANALYSER
- Author
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A Asmah, YNor Azma, AHNur Sabreena, and O Mohamad
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chemistry.chemical_classification ,chemistry.chemical_compound ,Stevia rebaudiana ,Chromatography ,Refractometer ,Chemistry ,Analyser ,Glycoside ,Steviol ,High-performance liquid chromatography - Published
- 2017
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15. Study of Some Trace Elements and Electrolytes in Idiopathic Generalized Epilepsy Syndromes
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Shora Y. Mostafa, Abdelmonem M. Hosny, and Wael O. Mohamad
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Idiopathic generalized epilepsy ,Trace (semiology) ,Pediatrics ,medicine.medical_specialty ,business.industry ,medicine ,medicine.disease ,business ,Psychiatry - Published
- 2016
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16. Renal dysfunctions/injury in adult epilepsy patients treated with carbamazepine or valproate
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Suzan M Abou Elnour, Tarek A. Rageh, Sherifa A. Hamed, and Amany O Mohamad
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Urinary system ,030232 urology & nephrology ,Renal function ,Kidney Function Tests ,Gastroenterology ,Kidney Tubules, Proximal ,03 medical and health sciences ,Epilepsy ,chemistry.chemical_compound ,Young Adult ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,General Pharmacology, Toxicology and Pharmaceutics ,Adverse effect ,Subclinical infection ,Valproic Acid ,Creatinine ,business.industry ,General Medicine ,Carbamazepine ,Middle Aged ,medicine.disease ,Cross-Sectional Studies ,chemistry ,Anticonvulsants ,Female ,Kidney Diseases ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Objectives Clinical and subclinical laboratory evidence of renal proximal tubular dysfunction had been reported in children with epilepsy as an adverse effect of some antiepileptic drugs (AEDs). This study aimed to determine kidney function in adult patients with monosymptomatic epilepsy of unknown etiology and treated with valproate (VPA) or carbamazepine (CBZ). Methods This study included 60 patients [mean age of 33.97 ± 6.70 years and treated with VPA (n = 24) or CBZ (n = 36) for mean duration of treatment of 6.03 ± 2.81years. Measurements of serum creatinine (sCr), urinary creatinine, creatinine clearance (CrCl) and serum kidney injury molecule 1 (KIM-1), markers of renal dysfunction/injury were done. Results Compared to controls, patients had higher sCr, KIM-1 and lower CrCl levels. Compared to patients on VPA, those on CBZ had relatively higher KIM-1 and lower CrCl levels. We reported only significant correlations between KIM-1 with sCr (r = 0.324, p = 0.001) and duration of treatment with AEDs (r = 0.301, p = 0.02). Conclusion Chronic VPA and CBZ therapy may be associated with subclinical renal glomerular and/or proximal tubular dysfunctions or injuries. The treating neurologist have to consider this while selection of AED on start treating patients or modifying the AED for patients at high risk of kidney injury.
- Published
- 2018
17. Assessing Predictors for Health Insurance Purchase Among Malaysian Public Sector Employees
- Author
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S. Norhasmah, O. Mohamad Amim, and A. R. Husniyah
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Government ,Data collection ,Actuarial science ,business.industry ,media_common.quotation_subject ,Multistage sampling ,Public sector ,Personality ,Sample (statistics) ,Business ,Investment (macroeconomics) ,Socioeconomic status ,media_common - Abstract
Challenges are faced by individuals in making financial decisions throughout their life to be financially well. Managing risk such as health risks may incur high cost to remain healthy. Individuals make decisions on having protection against health risks in the long run which depends on several factors. This study focused on the behavioral aspects of finance which attempts to assess factors predicting health insurance purchase among Malaysian public sector employees. The likelihood of personality and health risks factors in predicting health insurance purchase were determined. Multistage random sampling based on four zones in Peninsular Malaysia was utilized to sample 500 respondents from four states. Selected departments in the states were contacted prior to the data collection for their consent. Respondents identified by liaison officers in each department were given self-administered questionnaires resulting in 356 usable questionnaires. Apart from socioeconomic characteristics and health insurance purchase, data on investment, personality and health status were collected. Personalities measured were self-esteem, risk-averse and future-orientation, while health risks were measured through health status using SF-36. The primarily measures and the aggregate measures of health were analyzed in two separate binomial logistic regressions where both analyses revealed that income was the strongest predictor as compared to investment activity or self-esteem. None of the indicators for health risks was found to be significant in predicting health insurance purchase. Both models were justified as fit by being moderately correctly classified and were more than 25% improvement over the chance accuracy rate. It is concluded that the decision on protection against health risks using health insurance is not based on their health risks instead the decision depends more on their income. As these are employees in the public sector, it may reflect high reliance on the government health service. Nevertheless, the public sector is considered as a potential market for health insurance industry.
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- 2017
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18. Financial Risk Tolerance as a Predictor for Malaysian Employees’ Gold Investment Behavior
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S. Mohamad Fazli, A. R. Husniyah, Ahmad Fauzi, and O. Mohamad Amim
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Finance ,business.industry ,media_common.quotation_subject ,Financial risk ,Public sector ,Investment (macroeconomics) ,Product (business) ,Unit trust ,Promotion (rank) ,Market risk ,Gold as an investment ,Business ,health care economics and organizations ,media_common - Abstract
Economic uncertainty has led to the decision of investing in a much safer investment such as gold investment. Gold in the investment portfolio is perceived to safeguard individual investors against market risk. The Malaysian government has launched unit trust schemes under the Amanah Saham group which is a government-backed fail-safe investment. Gold investment, however, is a new phenomenon with very little promotion. The central bank has introduced the gold coin series while the private banking sector released few gold-related products. This study is performed to identify the purpose of investing, barriers to invest in gold and to ascertain financial risk tolerance as one of the predictor affecting gold investment behavior among Malaysian employees. Respondents in Peninsular Malaysia were sampled via a multistage random among urban public sector employees. Data from self-administered questionnaires revealed the main purpose to invest on gold was to have savings in the form of physical product. More than one-third of the 403 respondents reasoned out inavailability of funds for gold investment followed by the complication of gold investment procedures which they are not very familiar as the main barriers to gold investing. The significant predictors for gold investment behavior revealed were financial risk tolerance, gold investment attitude, subjective norms and perceived behavioral control with an explained variance of 30.4%. As gold investment is perceived as a safe investment, the result of financial risk tolerance as a positive significant predictor is not as expected. In addition, gold investment subjective norms surpassed the others in predicting gold investment behavior however gold investment knowledge is not significant in predicting investment on gold. It can be concluded that peer group is very important in determining a person’s intention to invest in gold. The results from this study may be utilised in marketing practices and business decisions.
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- 2017
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19. A Fellow’s Fate: Employment Outcomes of Radiation Oncology Fellowship Graduates
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O. Mohamad, K. Doke, S. Marcrom, A.M. Chen, T.J. Royce, and J.J. Meyer
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Cancer Research ,Radiation ,Oncology ,Radiology, Nuclear Medicine and imaging - Published
- 2018
- Full Text
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20. Identification of critical erosion prone areas in Temengor Reservoir Basin using Universal Soil Loss Equation (USLE) and Geographic Information System (GIS)
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E. Mohammad Basri, Su Yean Teh, O Mohamad Adam, and W. O. Wan Maznah
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Hydrology ,Identification (information) ,Universal Soil Loss Equation ,Geographic information system ,business.industry ,Erosion ,Environmental science ,General Medicine ,General Chemistry ,Structural basin ,business - Abstract
In this study, the Geographic Information System (GIS) was integrated with the Universal Soil Loss Equation (USLE) model to identify the risk of erosion at 360,000 ha in the Temengor Reservoir Basin. GIS was utilized as a tool for generating, manipulating and spatializing data from government agencies for sediment yield modelling and offering spatial input data to the erosion model. Meanwhile, USLE was used to predict the spatial distribution of the sediment yield on the grid basis. The five main parameters used in this study were the rainfall erosivity factor (R), topographic factor (LS), soil erodibility factor (K), crop management factor (C) and practice support factor (P). The R factor was calculated based on the annual rainfall data of the study area. The soil survey data was used to generate the K value and Digital Improvement Model (DEM) of the study area was used to generate LS factor. The values of C and P factors were derived from the land use map. After generating all parameters, analysis was performed to estimate the soil erosion using USLE model with spatial information analysis approach. It was discovered that the average annual soil loss in the study area was 8 t ha-1year-1and only 4% of the total area was under extreme erosion risk.
- Published
- 2019
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21. Strength and water absorption properties of lightweight concrete brick
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S Shahiron, J Zalipah, A H Noor Azlina, A Suraya Hani, K Nurul Amirah, W A Mohamad Nor Akasyah, M Y Nurain Izzati, A Sallehuddin Shah, and O Mohamad Hairi
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Brick ,Materials science ,Absorption of water ,Compressive strength ,Volume (thermodynamics) ,Composite material ,Expanded polystyrene ,Load bearing - Abstract
This study presented the strength and water absorption properties of lightweight concrete brick containing Expanded Polystyrene (EPS) as the material replacement for sand. EPS has been widely used by the construction industries in the production of lightweight building materials such as wall panel and lightweight concrete blocks. Hence, in this study, EPS has been used as the replacement material in the production of lightweight concrete brick. Replacement of sand by EPS was based on volume. The replacement percentage of EPS was 0%, 20%, 30%, 40% and 50%. The brick properties that have been investigated in this study were density, water absorption and compressive strength. Based on the experimental results, the density and compressive strength of the brick was decreased as the percentage of the replacement increased. Meanwhile, for water absorption properties, it was found that water absorption of the brick was decreased as the percentage of EPS increased. However, the properties obtained has satisfied the requirement where the brick density for lightweight should be less than 1680 kg/m3 and the strength for load bearing and non-load bearing brick is 11.7 MPa and 3.45 MPa for each individual unit. Meanwhile, for water absorption, the percentage of water absorption of brick should be less than 12% [1,2]. From this study, it was found that, the replacement of sand by EPS give significant impact towards strength and water absorption performance of concrete brick.
- Published
- 2019
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22. Strength and water absorption properties of lightweight concrete brick containing expanded polystyrene and palm oil fuel ash
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K Nurul Amirah, A Sallehuddin Shah, A J Mohamad Luthfi, O Mohamad Hairi, W A Mohamad Nor Akasyah, M Y Nurain Izzati, A Mohd Sufyan, S Shahiron, J Zalipah, and A Suraya Hani
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Cement ,Brick ,Materials science ,Absorption of water ,Bearing (mechanical) ,Compressive strength ,law ,Palm oil ,Cementitious ,Composite material ,Expanded polystyrene ,law.invention - Abstract
This paper is focusing on strength and water absorption properties of lightweight concrete brick containing Expanded Polystyrene (EPS) and Palm Oil Fuel Ash (POFA) as partial replacement materials of fine aggregates and cement respectively. EPS has been chosen as lightweight aggregates material due to its characteristic which is extremely light. Meanwhile, POFA has been chosen as cement replacement due to the cementitious characteristic which could act as the binder in the concrete mixture. The replacement percentage of EPS is 0%, 20%, 30%, 40% and 50% whilst the replacement percentage of POFA is 0%, 5%, 10%, 15%, 20% and 25%. The brick properties that have been investigated in this study are density, water absorption and compressive strength. Based on the experimental results, the density and compressive strength of the brick is decreased as the percentage of the replacement increased. Meanwhile, for water absorption, it was found that the percentage of water absorption of brick was increased as the percentage of POFA increased, and it was decreased as the percentage of EPS increased. Based on the findings, the properties obtained has satisfied the requirement where the brick density for lightweight should be less than 1680 kg/m3 and the strength for load bearing and non-load bearing brick is 11.7 MPa and 3.45 MPa for each individual unit. Meanwhile, for water absorption, the percentage of water absorption of brick should be less than 12% [1,2]. From this study, it was found that, the replacement of sand and cement by EPS and POFA give significant impact towards density, strength and water absorption performance of concrete brick.
- Published
- 2019
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23. AEROLLER: HERBICIDES ROLLER MACHINE FOR AEROBIC RICE WEED CONTROL
- Author
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O Mohamad Fakhrul Zaman, M. Shahril Shah Gs., A Mohd Hashim, M I Mohamed Fauzi, K Mohd Khusairy, Cindy Chan, H Ayob, M Abdul Rasad, O Azlan, and M N Saifulizan
- Subjects
Engineering ,Non target ,Agronomy ,Moisture ,business.industry ,Spray drift ,Soil preparation ,General Engineering ,Weed control ,business ,Weed ,Rice plant - Abstract
As wet land rice, aerobic rice is also faced with the problem of weeds management. The absences of stagnant water facilitating more weed species to survive and compete with rice plants. Therefore, soil preparation is crucial for reduce weed problems in addition to manual control, which focuses on the rate of herbicides, the growth of rice plants, plant moisture and weed species. The risk of spray drift would be eliminated if herbicides were wiped on to weeds rather than sprayed. A machine designed to apply herbicides using rolling wipers were assessed for their ability to apply constant amounts of herbicide to treated surfaces. The machine designed by developed a structure consist of weed ball applicator, a hose connect to a 300 liter reservoir tank which attached to the transplanter prime mover. Weed ball applicator treated strips 15cm wide and having a roller 100 cm length. Adjustments to the flow rate as the reservoir can be made using a control valve at weed ball devices and control valve at the reservoir tank. AeRoller application used by wipe the herbicide onto weeds instead of spraying. The risk of damage to nearby non target plant would be almost eliminated and treatment under windy conditions would be possible by wiping herbicide on to weeds rather than spraying. A field evaluation of the Aeroller showed that it had good potential for the applications of herbicides for controlling weeds on aerobic rice farm. The use of this rollers device system saves chemicals, reduce labor, reduce pollution on the environment and reduce worker exposure to dangerous herbicides.
- Published
- 2016
- Full Text
- View/download PDF
24. Enhancement of Detecting Wicked Website Through Intelligent Methods
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Salwa O. Mohamad and Tarik A. Rashid
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business.industry ,Computer science ,Intelligent decision support system ,02 engineering and technology ,Incitement ,Random forest ,World Wide Web ,Support vector machine ,Work (electrical) ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,The Internet ,State (computer science) ,business ,Hacker - Abstract
Noticeably, different environments of wicked website include different types of information which could be a threat for all web users such as incitement for hacking sites and encouraging them for spreading notions through learning theft networks, Wi-Fi, websites, internet forums, Facebook, email accounts, etc. The proposed work deals with sites to protect from hacking through designing a method that takes full advantage of machine learning and intelligent systems’ capabilities to realize the informative contents. The ultimate goal of this work of research is to understand the system behavior and determine the best solution to secure the vulnerable users, state and society via Random Forest (RF) and Support Vector Machines (SVM) methods instead of traditional methods. Random Forest exhibited Promising Results in terms of accuracy.
- Published
- 2016
- Full Text
- View/download PDF
25. Evaluation of Genotype x Environment Interaction on Morphological Characteristics of Eight Selected Labisia pumila var. alata Clones (Kacip Fatimah) by Francis and Kannenbergs Method
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S Norhayati, Fazwa, Farah, O Mohamad, and Syafiqah Nabilah
- Published
- 2016
- Full Text
- View/download PDF
26. Determination of the Optimum Time for Preparation of Half-Boiled Eggs Free from Salmonella Enterica Enteritidis
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A. M. Nurdiyana Syahirah, N. M. S. Siti Nurnajwa, A. M. N. Siti Farah, N. A. Nur Farhah, Zaini Mohd Zain, A. O. Mohamad Fithri, and Norsuhaida Zakaria
- Subjects
business.industry ,embryonic structures ,General Earth and Planetary Sciences ,Food science ,Microbial contamination ,Biology ,Food safety ,business ,Salmonella enterica serovar enteritidis ,General Environmental Science ,Food contaminant - Abstract
Introduction: Consuming half-boiled eggs during breakfast is popular among Malaysians. The eggs are usually prepared by submerging them in freshly boiled water for about 20 minutes duration. As chickens have the likelihood of harbouring Salmonella enterica Serovar Enteritidis in their eggs, it is feared that consumption of half-boiled eggs contaminated with S. Enteritidis could lead to gastroenteritis. Hence, this study was carried out to determine the optimum time required for boiled water to kill S. Enteritidis in half-boiled eggs. Methods: Grade C chicken eggs (average weight 54.5 g) were obtained from a local sundry shop and were confirmed to be Salmonella-free prior to the experiment. Fifteen eggs that were previously spiked with 106 colony-forming units (CFU) of S. Enteritidis were completely submerged into freshly-boiled water (≈100ºC) for a maximum of 20 min. Positive controls consisted of eggs that were inoculated but were not treated. At every 5 min interval, three eggs were taken out and checked for presence of viable S. Enteritidis on MacConkey agar, and the respective water temperature was recorded. Results: Results of two independent trials showed that after 10 min of submerging the eggs in the hot water, there were an average of 3 log reductions in the CFU of S. Enteritidis but after 15 min, no viable S. Enteritidis was detected. Conclusion: A half-boiled egg should be prepared by submerging it in freshly boiled water for at least 15 min to ensure that it is safe to be consumed.
- Published
- 2018
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27. PRELIMINARY PHYTOCHEMICAL SCREENING OF POLYSACCHARIDES CONTENT FOR SELECTION OF HIGH QUALITY PLANTING MATERIALS: Eurycoma longifolia
- Author
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A. Mohd Zaki, A. G. Ab. Rasip, M. A. Farah Fazwa, A. Mohd Radzi, L. Abdul Rashid, R. Nurnadiah, O Mohamad, J. Regina Mariah, N. Mohamad Lokmal, W. Nor Fadilah, and M. S. Ahmad Fauzi
- Subjects
chemistry.chemical_classification ,Actual weight ,Provenance ,Horticulture ,chemistry ,biology ,Phytochemical ,General Engineering ,Sowing ,Eurycoma longifolia ,Polysaccharide ,biology.organism_classification - Abstract
Provenance trial of Eurycoma longifolia is currently being carried out in order to provide necessary information for breeding strategies, which is crucially needed for the production of high quality planting materials. Assessment of polysaccharides content in the root part of the plant is taken among the important characteristics in the selection of the best provenance. Polysaccharides compound is chosen as bioactive marker due to the non-toxicity nature of the compound and potential pharmacological properties possessed. Polysaccharides compound of the root part is extracted by using water extract procedure from nine selected provenances (Johor, Melaka, Pahang A, Pahang B, Pahang D, Perak, Pulau Pinang, Selangor and Terengganu) of E. longifolia collected throughout forest reserves of Peninsular Malaysia. The analysis of the actual weight of the compound is conducted using phenol-sulfuric acid method by UV-VIS and High Performance Liquid Chromatography (HPLC) is used for the detection of structural components of the polysaccharides compound. The assessment showed that polysaccharides content in the root part of Terengganu provenance significantly has the highest with 1.06 % actual weight of polysaccharides (out of 30 g extracted dry roots). Meanwhile, there are four provenances showed undetectable range of polysaccharide content which were Melaka, Pahang A, Pulau Pinang and Selangor. In a nutshell, based on the preliminary assessment of polysaccharide content alone, Terengganu provenance has the potential to be declared among the best provenances that has high quality. The provenance trial also has taken into considerations several important parameters such as the growth performances variation and the tolerance of the plants to pests and diseases besides the phytochemical screening. Provenance trial of E. longifolia is still ongoing, data for various parameters are still being collected, and thus it is still too early to derive a conclusion of which is the best provenance.
- Published
- 2015
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28. Genetics of yield and its components in egg plant (Solanum melongena L.)
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O. Suhana, O. Mohamad, M. Abd. Rahman, M.A. Zubaid Akbar, O. Suhana, O. Mohamad, M. Abd. Rahman, and M.A. Zubaid Akbar
- Abstract
Inheritance study for yield and its components were conducted in five selected parents of brinjal namely MTE 1, MTE 2, Terung Bujur, Terung Telunjuk and NTH080077. Parents, F1 and F2 progenies were evaluated under field condition at MARDI, Serdang. Data on vegetative and yield components were recorded for parents F1 and F2 populations. Genetics study for inheritance were evaluated, and it showed that days to flower, fruit number per plant and fruit weight were observed as additive gene effect. Whereas, plant height and yield per plant were dominance gene effect. High heritability and high genetic advance were observed for fruit number per plant, fruit weight and yield per plant. Low and moderate phenotypic and coefficient of variations were observed for all traits. Moderate phenotypic and coefficient of variations were expressed by fruit number per plant, fruit weight and yield per plant. The selection of genotypes with high heritability coupled with genetic advance for these traits indicates the potential for crop improvement through selection.
- Published
- 2016
29. Optimization of Aging Time and Temperature for Four Malaysian Rice Cultivars
- Author
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Golam Faruq ., O. Mohamad ., M. Hadzim ., and C. A. Meisner .
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Horticulture ,Nutrition and Dietetics ,genetic structures ,Kernel (statistics) ,Botany ,information science ,Public Health, Environmental and Occupational Health ,food and beverages ,natural sciences ,Cultivar ,Elongation ,Food Science ,Mathematics - Abstract
Aging is a process that can develop rice-cooking quality. Specially, it helps to increase kernel elongation rate during cooking time. We have aged four popular Malaysian rice cultivars in different time and temperature conditions and we have observed that maximum good kernel elongation ratio for Mahsuri and Mahsuri Mutant are 100 C for 5 hours. In 9192, maximum kernel elongation ratio was observed at 110 C o o
- Published
- 2003
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30. Trends in Radiation Oncology Fellowship Training in the United States
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O. Mohamad and J.J. Meyer
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Cancer Research ,Radiation ,Oncology ,Radiology, Nuclear Medicine and imaging - Published
- 2017
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- View/download PDF
31. About ISCEE 2016
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A. Mohd Shalahuddin, L. Alvin John Meng Siang, M.J. Zainorizuan, O. Mohamad Hanifi, L. Yee Yong, and R. Siti Nazahiyah
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lcsh:TA1-2040 ,Engineering ethics ,lcsh:Engineering (General). Civil engineering (General) ,Engineering physics - Published
- 2017
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- View/download PDF
32. AEROLLER: HERBICIDES ROLLER MACHINE FOR AEROBIC RICE WEED CONTROL
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K., Mohd Khusairy, primary, H., Ayob, additional, C. S., Chan, additional, M. I., Mohamed Fauzi, additional, O., Mohamad Fakhrul Zaman, additional, GS., M. Shahril Shah, additional, O., Azlan, additional, M., Abdul Rasad, additional, A., Mohd Hashim, additional, and M. N., Saifulizan, additional
- Published
- 2016
- Full Text
- View/download PDF
33. Removal of patulin from apple juice using inactivated lactic acid bacteria
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S, Hatab, T, Yue, and O, Mohamad
- Subjects
Beverages ,Patulin ,Lactobacillaceae ,Malus ,Spectroscopy, Fourier Transform Infrared ,Humans ,Food Contamination ,Adsorption - Abstract
Apples and apple products are the most notably commodities contaminated with patulin (PAT), which cause detrimental effects on human health and economic problems. The primary objective of this study was to investigate the removal of PAT contamination from apple juice using 10 different inactivated lactic acid bacteria (LAB) strains.Significant quantities of PAT ranging from 47 to 80% were bound to all tested bacterial strains, whereas Lactobacillus rhamnosus 6224 and Enterococcus faecium 21605 caused a decrease of PAT by 80·4 and 64·5%, respectively. The results showed that the binding of PAT depends on the initial concentration of toxin and the adsorption temperature, also the differences in biomass existed among the 10 bacterial strains. IR analysis was performed to identify potential functional groups and the possible binding sites related to PAT adsorption.The removal of PAT was observed to be strain specific. The results indicated that the biosorption process did not affect the quality of juice. FTIR analysis showed that the cell wall plays a key role in PAT adsorption.Our results proof that inactivated LAB have the potential as a novel and promising adsorbent to bind PAT effectively.
- Published
- 2012
34. 2,2′-{1,1′-[2,2′-Oxalylbis(hydrazin-2-yl-1-ylidene)]diethylidyne}dipyridinium bis(perchlorate) dihydrate
- Author
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Goran N. Kaluderović, Rabia O. Mohamad Eshkourfu, Santiago Gómez-Ruiz, Dragana Mitić, and Katarina K. Andelković
- Subjects
Crystallography ,QD901-999 - Abstract
The title salt, C16H18N6O22+·2ClO4−·2H2O, was obtained unintentionally as a major product in the reaction of Zn(ClO4)2·6H2O with the N′,N′2-bis[(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (H2L) ligand. The (H4L)2+ cation lies across a centre of inversion. The pyridiniumimine fragments of (H4L)2+ adopt syn orientations. Intramolecular N—H...N and N—H...O hydrogen bonds lead to the formation of S(5) motifs. In the crystal, neighbouring cations are connected by π–π interactions between pyridinium units with a centroid–centroid distance of 3.600 (1) Å. Moreover, the crystal components are assembled into two-dimensional layers via N—H...O and O—H...O hydrogen bonds, with no direct hydrogen-bonding interactions between cations.
- Published
- 2010
35. Abstracts of Posters Presentations
- Author
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T. E. Bureau, G. S. Khush, S. R. Wessler, A. S. Reddy, F. Cordesse, M. Delseny, A. Kanno, K. Hattori, A. Hirai, Y. Sano, R. Sano, H. -Y. Hirano, T. Ishii, T. Terachi, N. Mori, K. Tsunewaki, J. P. Gustafson, C. L. Mclntyre, J. E. Dillé, Jinshui Yang, Koulin Ge, Yunzhu Wang, C. C. Tan, Shanbao Chen, Xiaolan Duan, Changsheng Yan, Guandang Xing, Yan Zhang, B. Wang, H. G. Zheng, Q. F. Xu, J. Z. Wang, D. D. Li, S. T. Li, Z. T. Zhang, O. Panaud, G. Magpantay, E. Galinato, D. Mahapatra, L. A. Sitch, S. Yoshimura, A. Yoshimura, N. Iwata, A. Saito, N. Kishimoto, M. Kawase, M. Nakagahra, M. Yano, N. Mitsukawa, K. Tanaka, E. C. Cocking, S. L. Kothari, H. Zhang, P. T. Lynch, P. S. Eyles, E. L. Rech, M. R. Davey, I. H. Slamet, R. P. Finch, K. -I. Mori, T. Kinoshita, A. Tanaka, S. Tano, A. B. Mendoza, Y. Futsuhara, Y. Takeoka, Wang Zixuan, E. Guiderdoni, P. B. Kavi Kishor, G. M. Reddy, N. R. Yadav, D. R. Sharma, J. B. Chowdhury, Jiadao Wu, Zhongxiang Huang, Zuling Liu, Leya Zheng, Jianbo Yan, Yan Chen, K. Fukui, K. Iijima, H. Fukuoka, Y. Kageyama, K. Yamamoto, G. Takeda, I. Imuta, F. Kikuchi, I. Watanabe, M. Yusa, O. Kamijima, H. Kitano, Y. Nagato, S. Kikuchi, H. Satoh, I. Takamure, S. Oba, M. Ichii, Shui Shan Li, H. Hasegawa, A. Matsuzaki, T. Takano, T. Kato, D. A. Vaughan, K. K. Jena, D. S. Multani, A. Ghesquiere, P. Barbier, A. Ishihama, A. A. Flores-Nimedez, K. Dörffling, B. S. Vergara, T. Nagamine, K. Watanabe, T. Nishimura, T. Ogawa, R. E. Tabien, T. Yamamoto, G. A. Busto, R. Ikeda, C. Hamamatsu, Y. -I. Sato, H. Morishima, J. Abadassi, J. C. Glaszmann, J. L. Notteghem, B. Courtois, O. Mohamad, M. Z. Abdullah, O. Othman, K. Hadzim, J. Mahmud, O. Ramli, J. L. Minocha, J. S. Sidhu, R. K. Gupta, H. Sano, S. Youssefian, I. Kamada, M. Itoh, M. T. Mei, Q. F. Zuo, Y. G. Lu, H. Deng, T. C. Yang, T. Tanisaka, H. Yamagata, B. Mishra, J. P. Tilquin, J. P. Chapeaux, J. F. Detry, Yi-Shin Chen, Chia-Yi Aes, Bui Chi Buu, Thai Thi Hanh, Minghong Gu, Aiqing You, Xuebiao Pan, Zu-bai Qi, Ye-Tong Cai, Bao-jian Li, T. Nomura, K. Yonezawa, T. Sato, N. Watanabe, R. B. Austin, C. L. Morgan, Y. Okumoto, Y. Shimamoto, Shih-Cheng Lin, K. Hinata, M. Oka, M. P. Pandey, D. V. Seshu, M. Akbar, Moo Young Eun, Yong Gu Cho, Yong Kwon Kim, Tae Young Chung, Gun-Sik Chung, Sae-Jun Yang, Byeong-Geun Oh, G. L. Shrestha, S. Mallik, A. M. Aguilar, G. Kochert, and I. Nakamura
- Published
- 2008
- Full Text
- View/download PDF
36. Aerobic rice mechanization: techniques for crop establishment
- Author
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K M Khusairy, H Ayob, C S Chan, M I Mohamed Fauzi, Z O Mohamad Fakhrul, G S M Shahril Shah, O Azlan, M A Rasad, A M Hashim, Z Arshad, E Ibrahim E, and M N Saifulizan
- Subjects
Engineering ,business.industry ,fungi ,food and beverages ,Sowing ,Staple food ,Seeder ,Crop ,Water resources ,Agronomy ,Agriculture ,Paddy field ,business ,Mechanization - Abstract
Rice being the staple food crops, hundreds of land races in it makes the diversity of rice crops. Aerobic rice production was introduced which requires much less water input to safeguard and sustain the rice production and conserve water due to decreasing water resources, climatic changes and competition from urban and industrial users. Mechanization system plays an important role for the success of aerobic rice cultivation. All farming activities for aerobic rice production are run on aerobic soil conditions. Row seeder mechanization system is developed to replace conventional seeding technique on the aerobic rice field. It is targeted for small and the large scale aerobic rice farmers. The aero - seeder machine is used for the small scale aerobic rice field, while the accord - seeder is used for the large scale aerobic rice field. The use of this mechanization machine can eliminate the tedious and inaccurate seeding operations reduce labour costs and increases work rate. The machine is easy to operate and it can increase crop establishment rate. It reduce missing hill, increasing planting and crop with high yield can be produce. This machine is designed for low costs maintenance and it is easy to dismantle and assemble during maintenance and it is safe to be used.
- Published
- 2015
- Full Text
- View/download PDF
37. Comparison of Reference Current Generation Techniques for Non-active Power Compensation Under Distorted and Unbalanced Conditions
- Author
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K. Chariff, O. Rafael, O. Mohamad, and S. Daniel
- Subjects
Engineering ,Electric power system ,Control theory ,business.industry ,Harmonic ,Power factor ,Voltage source ,AC power ,business ,Active filter ,Voltage ,Reference frame - Abstract
This article presents a comparison of two reference non-active current generation techniques for power compensation under unbalanced and distorted source voltage conditions and unbalanced loads. Two techniques are evaluated: Fryze's General Equation (FGE) and the Positive Sequence Magnitude by the Synchronous Reference Frame Method (PSM-SRF). These techniques are evaluated in terms of the compensation performance of a three-phase shunt active filter in a four wire power system. The reference current generation techniques are stated theoretically and the comparison is evaluated on simulation and experimental results. The more important results are that both techniques allow harmonic and reactive components elimination under any conditions, the unity power factor correction is achieved only by the FGE technique, but this technique balances the source currents only under distorted voltage and unbalanced load conditions, and source currents balancing and neutral current elimination are achieved under any condition only by the PSM-SFR technique.
- Published
- 2006
- Full Text
- View/download PDF
38. Investigating the Effect of Pressure on Water Leakage by Drip Irrigation without a Pump in Four Different Ejectors
- Author
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M. khast, M. Hesam, A. Hezarjaribi, and O. Mohamadi
- Subjects
irrigation kit ,drip irrigation ,discharge ,uniformity factor ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
Due to the increasing number of small crops, the system of irrigation without a pump can be an economical way. Therefore, in this research, the effects of the type of droplet and the height of water supply system utilization on the characteristics of water distribution (discharge, dispersion uniformity coefficient (CU) and coefficients of variation of discharge) were investigated. In this research, the pressure functions of 1, 2, 3 and 4 meters and three irrigation repeats were investigated; also, the discharge characteristics of jet pots of 2 and 8 nozzles, easy dripper and netafim were addressed. The results indicated that at 1 m pressure, drippers of pots of 2 and 8 nozzles with the uniformity coefficients of distribution were equal to 89.39 and 99.30%, and the discharge rate was 3.60 and 3.62 liters per hour at a pressure of 2 m. An easy-drain drip with a discharge rate of 3.85 L / h and a uniform distribution of 99.44%, at a height of 3 and 4 m, the droplets of the netafim with an outlet discharge were 3.87 and 3.97 liters per hour and the uniformity coefficients of 99.32 and 99.47 percent had the best broadcast conditions. According to these significant differences (P
- Published
- 2020
39. 2,2 '-{1,1 '-[2,2 '-Oxalylbis(hydrazin-2-yl-1-ylidene)]diethylidyne}dipyridinium bis(perchlorate) dihydrate
- Author
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Kaluđerović, Goran N., Eshkourfu, Rabia O. Mohamad, Gomez-Ruiz, Santiago, Mitić, Dragana, Anđelković, Katarina K., Kaluđerović, Goran N., Eshkourfu, Rabia O. Mohamad, Gomez-Ruiz, Santiago, Mitić, Dragana, and Anđelković, Katarina K.
- Abstract
The title salt, C(16)H(18)N(6)O(2)(2+)center dot 2ClO(4)(-)center dot 2H(2)O, was obtained unintentionally as a major product in the reaction of Zn(ClO(4))(2)center dot 6H(2)O with the N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (H(2)L) ligand. The (H(4)L)(2+) cation lies across a centre of inversion. The pyridiniumimine fragments of (H(4)L)(2+) adopt syn orientations. Intramolecular N-H center dot center dot center dot N and N-H center dot center dot center dot O hydrogen bonds lead to the formation of S(5) motifs. In the crystal, neighbouring cations are connected by pi-pi interactions between pyridinium units with a centroid-centroid distance of 3.600 (1) angstrom. Moreover, the crystal components are assembled into two-dimensional layers via N-H center dot center dot center dot O and O-H center dot center dot center dot O hydrogen bonds, with no direct hydrogen-bonding interactions between cations.
- Published
- 2010
40. Evaluation of COD and BOD5 Removal Efficiency by Combined Treatment Aerobic-Anaerobic (AO) on Sewage of Metal Industries
- Author
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O. Mohamadi, M. Heidarpour, and S. Jamali
- Subjects
anaerobic biological treatment ,biological oxygen demand ,chemical oxygen demand ,hydraulic retention time ,unconventional water ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
Shortage of water resources and renewable per capita in last 30 years is put Iran on crisis threshold. Wastewater reuse is one of the battle solutions for water shortage and prevents wastewater depletion and environmental pollution. Thus, a pilot scale experiment was carried out to evaluate an integrated anaerobic/aerobic treatment for removal of BOD5 and COD, also to reduction of hydraulic retention time by considering optimum removal efficiency. The pilot was an anaerobic/aerobic bioreactor type under continuous-feeding regime based on a central composite design. The pilot was studied in different retention time and aeration was carried out between 5-15 hours. According to different retention times for COD removal efficiency, 24 hours was selected as optimum hydraulic retention time, that it is comparable to those obtained for 48 hours and over in plant roughly and could remove COD and BOD in acceptable ranges, results showed that average removal efficiency for BOD5 were 63.86 and 83.99 percent in aerobic and anaerobic phases, respectively. The average removal efficiency for COD was 76.5 and 74.35 percent for anaerobic and aerobic sections, respectively. The average removal efficiency for BOD5 and COD in this integrated aerobic-anaerobic pilot 95.24 and 94.8 percent, respectively.
- Published
- 2019
41. Optimization of Aging Time and Temperature for Four Malaysian Rice Cultivars
- Author
-
., Golam Faruq, primary, ., O. Mohamad, additional, ., M. Hadzim, additional, and ., C. A. Meisner, additional
- Published
- 2003
- Full Text
- View/download PDF
42. Strength and water absorption properties of lightweight concrete brick.
- Author
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M Y Nurain Izzati, A Suraya Hani, S Shahiron, A Sallehuddin Shah, O Mohamad Hairi, J Zalipah, A H Noor Azlina, W A Mohamad Nor Akasyah, and K Nurul Amirah
- Published
- 2019
- Full Text
- View/download PDF
43. Strength and water absorption properties of lightweight concrete brick containing expanded polystyrene and palm oil fuel ash.
- Author
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A Suraya Hani, M Y Nurain Izzati, A Sallehuddin Shah, S Shahiron, O Mohamad Hairi, A Mohd Sufyan, A J Mohamad Luthfi, J Zalipah, W A Mohamad Nor Akasyah, and K Nurul Amirah
- Published
- 2019
- Full Text
- View/download PDF
44. Challenges in Construction Over Soft Soil - Case Studies in Malaysia.
- Author
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N O Mohamad, C E Razali, A A A Hadi, P P Som, B C Eng, M B Rusli, and F R Mohamad
- Published
- 2016
- Full Text
- View/download PDF
45. Prevalence of glucose-6-phosphate dehydrogenase deficiency (G6PDd), CareStart qualitative rapid diagnostic test performance, and genetic variants in two malaria-endemic areas in Sudan
- Author
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Musab M. Ali Albsheer, Andrew A. Lover, Sara B. Eltom, Leena Omereltinai, Nouh Mohamed, Mohamed S. Muneer, Abdelrahim O. Mohamad, and Muzamil Mahdi Abdel Hamid
- Subjects
Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is the most common enzymopathy globally, and deficient individuals may experience severe hemolysis following treatment with 8-aminoquinolines. With increasing evidence of Plasmodium vivax infections throughout sub-Saharan Africa, there is a pressing need for population-level data at on the prevalence of G6PDd. Such evidence-based data will guide the expansion of primaquine and potentially tafenoquine for radical cure of P. vivax infections. This study aimed to quantify G6PDd prevalence in two geographically distinct areas in Sudan, and evaluating the performance of a qualitative CareStart rapid diagnostic test as a point-of-care test. Blood samples were analyzed from 491 unrelated healthy persons in two malaria-endemic sites in eastern and central Sudan. A pre-structured questionnaire was used which included demographic data, risk factors and treatment history. G6PD levels were measured using spectrophotometry (SPINREACT) and first-generation qualitative CareStart rapid tests. G6PD variants (202 G>A; 376 A>G) were determined by PCR/RFLP, with a subset confirmed by Sanger sequencing. The prevalence of G6PDd by spectrophotometry was 5.5% (27/491; at 30% of adjusted male median, AMM); 27.3% (134/491; at 70% of AMM); and 13.1% (64/490) by qualitative CareStart rapid diagnostic test. The first-generation CareStart rapid diagnostic test had an overall sensitivity of 81.5% (95%CI: 61.9 to 93.7) and negative predictive value of 98.8% (97.3 to 99.6). All persons genotyped across both study sites were wild type for the G6PD G202 variant. For G6PD A376G all participants in New Halfa had wild type AA (100%), while in Khartoum the AA polymorphism was found in 90.7%; AG in 2.5%; and GG in 6.8%. Phenotypic G6PD B was detected in 100% of tested participants in New Halfa while in Khartoum, the phenotypes observed were B (96.2%), A (2.8%), and AB (1%). The African A- phenotype was not detected in this study population. Overall, G6PDd prevalence in Sudan is low-to-moderate but highly heterogeneous. Point-of-care testing with the qualitative CareStart rapid diagnostic test demonstrated moderate performance with moderate sensitivity and specificity but high negative predicative value. The two sites harbored primarily the African B phenotype. A country-wide survey is recommended to understand GP6PD deficiencies more comprehensively in Sudan. Author summary Malaria is caused by five species of parasites; of these Plasmodium falciparum and P. vivax cause the majority of global morbidity and mortality. Plasmodium vivax infection is an emerging public health problem in sub-Saharan Africa, including Sudan. Primaquine and other 8-aminoquinolines including tafenoquine are the primary treatments to target the silent liver stage (hypnozoites) in P. vivax infections. However, these regimens can cause severe intravascular hemolysis in patients suffering from glucose-6-phosphate dehydrogenase deficiency (G6PDd). To support safe and efficacious use of primaquine, and potentially tafenoquine in Sudan, this study aimed to estimate the prevalence of G6PDd across two sites in Sudan using spectrophotometry and a qualitative CareStart rapid diagnostic test. Subsequent genetic analysis by PCR/RFLP and sequencing of G6PD genetic variants was performed. This survey found an overall prevalence was 5.5% (27/491; 30% of adjusted male median, AMM), and 27.3% (134/491; 70% of AMM) and 13.1% (64/490) by qualitative CareStart rapid diagnostic test. Important differences in distribution of genetic variants of G6PD were found across the two sites, and the African A- was not observed. In univariate analysis a few parameters showed significant association with G6PD deficiency. In conclusion the prevalence of G6PDd was low to moderate but heterogonous, and the first-generation qualitative CareStart rapid diagnostic test showed moderate performance in both males and females.
- Published
- 2021
46. Effect of concomitant medications on treatment response and survival in non-metastatic castrate resistant prostate cancer: Exploratory analysis of the SPARTAN trial.
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Roy S, Saad F, Sun Y, Malone S, Spratt DE, Kishan AU, Wallis CJD, Jia AY, Mohamad O, Swami U, Ong M, Agarwal N, Chowdhury S, and Morgan SC
- Subjects
- Humans, Male, Aged, Metformin therapeutic use, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Aspirin therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Middle Aged, Androgen Antagonists therapeutic use, Proton Pump Inhibitors therapeutic use, Prostatic Neoplasms, Castration-Resistant drug therapy, Prostatic Neoplasms, Castration-Resistant mortality, Prostatic Neoplasms, Castration-Resistant pathology, Thiohydantoins therapeutic use
- Abstract
Background: We performed an exploratory analysis of the SPARTAN trial to determine whether concomitant exposure to several classes of commonly prescribed medications influenced the effect of apalutamide on overall survival (OS) and metastasis-free survival (MFS) in patients with non-metastatic castration-resistant prostate cancer (nmCRPC)., Patients and Methods: SPARTAN was a phase III randomized controlled trial in which nmCRPC patients were randomly assigned in a 2:1 ratio to receive androgen deprivation therapy with or without apalutamide. We focused on 5 commonly prescribed classes of medications: metformin, statins, angiotensin converting enzyme inhibitors (ACEI), acetylsalicylic acid (ASA), and proton pump inhibitors (PPI) based on a plausible biological and clinical rationale. To determine the potential effect modification, we applied multivariable Cox regression models for OS and MFS separately with additional interaction terms. To determine the independent association of concomitant medications with OS and MFS, we used IPTW-based log-rank test. A 2-sided p < 0.01 was considered statistically significant., Results: We did not find statistically significant differences in effect from apalutamide on OS across subgroups stratified by concomitant exposure to any of the medication classes. While there was some difference in the treatment effect from apalutamide on MFS between patients with concomitant statins (adjusted hazard ratio [aHR]: 0.20; 95 % CI: 0.15-0.28) versus without concomitant statins (aHR: 0.31 [0.24-0.39]), this did not reach the pre-specified threshold of statistical significance (p = 0.011). On IPTW-based analysis, patients treated concomitantly with metformin (median: not reached versus 31 months; p = 0.002), or ACEI (median: 37 versus 29 months, p = 0.006) had significantly improved MFS., Conclusions: In this post-hoc exploratory analysis of SPARTAN, effects of apalutamide on MFS and OS were consistent across subgroups stratified by exposure to concomitant medications. Exposure to concomitant metformin and ACEI was independently associated with a significant improvement in MFS., Competing Interests: Declaration of Competing Interest Dr. Roy reports Young Investigator Award from the Prostate Cancer Foundation which funded this research. In addition, Dr. Roy reports research grant from Swim Across America and honorarium from Varian. Dr. Spratt reports personal fees from Blue Earth, personal fees from Janssen, personal fees from AstraZeneca, Gammatile, Varian, and Boston Scientific, outside the submitted work. Dr. Kishan reported receiving personal fees from ViewRay, Inc, Varian Medical Systems, and Boston Scientific; receiving speaking honoraria, consulting fees, and research support from Varian Medical Systems, ViewRay, Inc, and Intelligent Automation; receiving grants from Janssen and Point Biopharma; and receiving research funding from ViewRay, Inc, outside the submitted work. Dr. Agarwal reports consulting or advisory roles for Pfizer, Medivation/Astellas, Bristol Myers Squibb, AstraZeneca, Nektar, Lilly, Bayer, Pharmacyclics, Foundation Medicine, Astellas Pharma, Lilly, Exelixis, Merck, Novartis, Eisai, Seagen, EMD Serono, Janssen Oncology, AVEO, Calithera Biosciences, MEI Pharma, Genentech, Astellas Pharma, Foundation Medicine, Gilead Sciences and research funding from Bayer, Bristol Myers Squibb, Takeda, Pfizer, Exelixis, Amgen, AstraZeneca, Calithera Biosciences, Celldex, Eisai, Immunomedics, Janssen, Merck, Lilly, Nektar, ORIC Pharmaceuticals, crispr therapeutics, and Arvinas. Dr. Chowdhury, receiving honoraria, fees for serving on a speaker’s bureau, consulting fees, and travel support from Johnson and Johnson, Astellas Pharma, and Sanofi and grant support, honoraria, fees for serving on a speaker’s bureau, consulting fees, and travel support from Clovis Oncology. Dr. Jia reports personal fees from Blue Earth, and Myovant. Dr. Ong reports personal fees from Janssen, Bayer, AstraZeneca, and Pfizer. Dr. Morgan reports personal fees from Astellas, Bayer, Janssen, and TerSera and a research grant (institutional) from Knight Therapeutics, outside the submitted work. Dr. Swami reports consultancy to Astellas, Exelixis, Seattle Genetics, Imvax, Sanofi, Pfizer, AstraZeneca and Gilead and research funding to institute from Janssen, Exelixis and Astellas/Seattle Genetics. Dr. Saad reports grants, personal fees, and non-financial support from Janssen, during the conduct of the study; grants, personal fees, and non-financial support from Astellas, grants, personal fees, and non-financial support from Bayer, outside the submitted work. Dr. Wallis has received honoraria from AbbVie, Astellas, Astra Zeneca, Bayer, EMD Serono, Knight Therapeutics, Merck, Haymarket Media, Science & Medicine Canada, TerSera Canada, and Tolmar Pharmaceuticals Canada; reports consulting fees from Janssen Oncology, SESEN Bio, and Precision Point Specialty LLC; and has received research funding from Knight Therapeutics and Tolmar Pharmaceuticals, outside the submitted work. Dr. Malone has received honoraria from Astellas, Bayer, Janssen, and Sanofi; and travel and accommodations support from TerSera and Sanofi. There are no other conflicts of interest among the other authors., (Copyright © 2024. Published by Elsevier Ltd.)
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- 2024
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47. Machine learning and explainable artificial intelligence to predict pathologic stage in men with localized prostate cancer.
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Semwal H, Ladbury C, Sabbagh A, Mohamad O, Tilki D, Amini A, Wong J, Li YR, Glaser S, Yuh B, and Dandapani S
- Abstract
Background: Though several nomograms exist, machine learning (ML) approaches might improve prediction of pathologic stage in patients with prostate cancer. To develop ML models to predict pathologic stage that outperform existing nomograms that use readily available clinicopathologic variables., Methods: Patients with prostate adenocarcinoma who underwent surgery were identified in the National Cancer Database. Seven ML models were trained to predict organ-confined (OC) disease, extracapsular extension, seminal vesicle invasion (SVI), and lymph node involvement (LNI). Model performance was measured using area under the curve (AUC) on a holdout testing data set. Clinical utility was evaluated using decision curve analysis (DCA). Performance metrics were confirmed on an external validation data set., Results: The ML-based extreme gradient boosted trees model achieved the best performance with an AUC of 0.744, 0.749, 0.816, 0.811 for the OC, ECE, SVI, and LNI models, respectively. The MSK nomograms achieved an AUC of 0.708, 0.742, 0.806, 0.802 for the OC, ECE, SVI, and LNI models, respectively. These models also performed the best on DCA. Findings were consistent on both a holdout internal validation data set as well as an external validation data set., Conclusions: Our ML models better predicted pathologic stage relative to existing nomograms at predicting pathologic stage. Accurate prediction of pathologic stage can help oncologists and patients determine optimal definitive treatment options for patients with prostate cancer., (© 2024 Wiley Periodicals LLC.)
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- 2024
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48. The Relationship Between Travel Distance for Treatment and Outcomes in Patients Undergoing Radiation Therapy: A Systematic Review.
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Silverwood SM, Waeldner K, Demeulenaere SK, Keren S, To J, Chen JJ, Kouzi ZE, Ayoub A, Grover S, Lichter KE, and Mohamad O
- Abstract
Purpose: Although recent technological advances in radiation therapy have significantly improved treatment outcomes, the global distribution of radiation therapy is unbalanced, making access especially challenging for patients in rural or low-resource settings because of travel burden. This systematic review aimed to explore the impact of geographic distance to treatment facilities on survival, as well as other treatment outcomes, among patients undergoing radiation therapy., Methods and Materials: A search of four databases (PubMed, Embase, CINAHL, and Web of Science) was performed. Studies were included if they were primary literature, published between May 2000 and May 2023, and reported the travel distances for patients undergoing radiation therapy for malignant conditions and its influence on survival outcomes. Studies were excluded if they did not report primary outcomes, were published before 2000, or were non-English., Results: After review, 23 studies were included. Most studies were conducted in the United States, with cervical cancer being the most frequently studied disease site. Data suggested that travel distances vary significantly, with patients often traveling a median distance of 20 miles to radiation therapy. Among the studies, 5 reported a negative impact on overall survival, often associating greater travel with nonadherence to recommended care. Other survival metrics, including progression-free survival and all-cause mortality, were also assessed, demonstrating similar variability in relation to travel distance. Conversely, seven studies found no significant impact on overall survival, and four suggested a positive impact on overall survival, with improved outcomes at centers with higher case volumes. Some data also revealed an inverse correlation between travel distance and the likelihood of receiving guideline-concordant radiation therapy., Conclusions: The impact of travel distance on radiation therapy outcomes is varied. Our findings underscore the challenges posed by travel in accessing radiation therapy and the disparities affecting particular patient demographic groups. Additional studies are needed to thoroughly assess the impacts of geographic disparities and to identify effective measures to address these challenges., (© 2024 The Authors.)
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- 2024
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49. Prostate Cancer Risk Stratification in NRG Oncology Phase III Randomized Trials Using Multimodal Deep Learning With Digital Histopathology.
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Tward JD, Huang HC, Esteva A, Mohamad O, van der Wal D, Simko JP, DeVries S, Zhang J, Joun S, Showalter TN, Schaeffer EM, Morgan TM, Monson JM, Wallace JA, Bahary JP, Sandler HM, Spratt DE, Rodgers JP, Feng FY, and Tran PT
- Subjects
- Humans, Male, Risk Assessment methods, Aged, Randomized Controlled Trials as Topic, Middle Aged, Clinical Trials, Phase III as Topic, Prostatic Neoplasms pathology, Deep Learning
- Abstract
Purpose: Current clinical risk stratification methods for localized prostate cancer are suboptimal, leading to over- and undertreatment. Recently, machine learning approaches using digital histopathology have shown superior prognostic ability in phase III trials. This study aims to develop a clinically usable risk grouping system using multimodal artificial intelligence (MMAI) models that outperform current National Comprehensive Cancer Network (NCCN) risk groups., Materials and Methods: The cohort comprised 9,787 patients with localized prostate cancer from eight NRG Oncology randomized phase III trials, treated with radiation therapy, androgen deprivation therapy, and/or chemotherapy. Locked MMAI models, which used digital histopathology images and clinical data, were applied to each patient. Expert consensus on cut points defined low-, intermediate-, and high-risk groups on the basis of 10-year distant metastasis rates of 3% and 10%, respectively. The MMAI's reclassification and prognostic performance were compared with the three-tier NCCN risk groups., Results: The median follow-up for censored patients was 7.9 years. According to NCCN risk categories, 30.4% of patients were low-risk, 25.5% intermediate-risk, and 44.1% high-risk. The MMAI risk classification identified 43.5% of patients as low-risk, 34.6% as intermediate-risk, and 21.8% as high-risk. MMAI reclassified 1,039 (42.0%) patients initially categorized by NCCN. Despite the MMAI low-risk group being larger than the NCCN low-risk group, the 10-year metastasis risks were comparable: 1.7% (95% CI, 0.2 to 3.2) for NCCN and 3.2% (95% CI, 1.7 to 4.7) for MMAI. The overall 10-year metastasis risk for NCCN high-risk patients was 16.6%, with MMAI further stratifying this group into low-, intermediate-, and high-risk, showing metastasis rates of 3.4%, 8.2%, and 26.3%, respectively., Conclusion: The MMAI risk grouping system expands the population of men identified as having low metastatic risk and accurately pinpoints a high-risk subset with elevated metastasis rates. This approach aims to prevent both overtreatment and undertreatment in localized prostate cancer, facilitating shared decision making.
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- 2024
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50. Prior Local Therapy and First-Line Apalutamide in Patients With Nonmetastatic Castration-Resistant Prostate Cancer: A Secondary Analysis of the SPARTAN Randomized Clinical Trial.
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Roy S, Malone S, Wing K, Chowdhury S, Kishan AU, Sun Y, Wallis CJD, Mohamad O, Jia AY, Swami U, Zaorsky NG, Morgan SC, Ong M, Agarwal N, Spratt DE, Small EJ, and Saad F
- Subjects
- Humans, Male, Aged, Middle Aged, Prostatectomy methods, Double-Blind Method, Antineoplastic Agents therapeutic use, Thiohydantoins therapeutic use, Prostatic Neoplasms, Castration-Resistant drug therapy, Prostatic Neoplasms, Castration-Resistant mortality
- Abstract
Importance: Preclinical studies suggest that exposure to prostate-directed local therapy (LT) may influence the efficacy of subsequent systemic therapy including androgen receptor pathway inhibitors. However, there is insufficient clinical evidence to support this premise in patients with nonmetastatic castrate-resistant prostate cancer (nmCRPC)., Objective: To determine whether exposure to prior prostate-directed LT (radical prostatectomy [RP], radiation therapy [RT], or both) played any effect-modifying role in the treatment effect of apalutamide on metastasis-free survival (MFS) and overall survival (OS) in patients with nmCRPC., Design, Setting, and Participants: This post hoc secondary analysis used individual patient data from SPARTAN (Study of Apalutamide [ARN-509] in Men With Non-Metastatic Castration-Resistant Prostate Cancer), a phase 3, double-blinded, placebo-controlled randomized clinical trial conducted at 332 sites in 26 countries. Between October 14, 2013, and December 15, 2016, patients with nmCRPC and a prostate-specific antigen doubling time of 10 months or less were randomly assigned to apalutamide vs placebo; all patients received androgen deprivation therapy. The final data analysis was performed on December 31, 2023., Exposure: Prior prostate-directed LT., Main Outcomes and Measures: Separate Cox proportional hazards regression models were constructed for OS and MFS, which included prior LT, treatment group, and an interaction term, in addition to a minimally sufficient set of confounders. Adjusted hazard ratios (HRs) with 95% CIs for MFS and OS were determined for the apalutamide groups with or without prior LT., Results: Among the 1179 evaluable patients included in this analysis, 795 received prior LT and 384 did not. The median age of patients with and without prior LT was 70 (IQR, 45-90) years and 75 (IQR, 50-95) years, respectively. The median follow-up was 52.0 (IQR, 51.5-52.8) months. A differential treatment effect of apalutamide on MFS was observed between patients with and without prior LT (P for interaction = .009), with greater benefits for those with prior LT (adjusted HR, 0.22 [95% CI, 0.17-0.27]) compared with those without prior LT (adjusted HR, 0.35 [95% CI, 0.25-0.51]). However, there was insufficient evidence of a differential treatment effect on OS among subgroups stratified by exposure to prior LT (P for interaction = .23), with improved OS in the subgroup with prior LT (adjusted HR, 0.72 [95% CI, 0.57-0.92]) but no significant difference in OS in the subgroup without prior LT (adjusted HR, 0.92 [95% CI, 0.64-1.31])., Conclusions and Relevance: This post hoc analysis of the SPARTAN trial provides evidence of an interaction between prior LT and apalutamide in patients with nmCRPC, with a clinically significant and more favorable treatment effect from apalutamide on MFS among patients with prior LT. Further studies are needed to validate these findings., Trial Registration: ClinicalTrials.gov Identifier: NCT01946204.
- Published
- 2024
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