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173 results on '"O. Lourenço"'

1. Pseudoscalar mesons from a PNJL model at zero temperature

Author

R. M. Aguirre and O. Lourenço

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We study pseudoscalar $$\pi $$ π , K and $$\eta $$ η meson properties, such as masses and couplings, in dense matter at zero temperature. We use a recently proposed phenomenological quark model, known as the PNJL0, which takes into account the confinement/deconfinement phase transition by means of the traced Polyakov loop ( $$\varPhi $$ Φ ) which serves as an order parameter at zero temperature. We consider two different scenarios, namely, symmetric quark matter with equal chemical potentials for all the flavors, and the beta equilibrated matter. In the latter case the hadron-quark phase transition is implemented by a two model approach. For the hadron side we use a relativistic mean-field model with density dependent couplings. We show that $$\varPhi $$ Φ induces abrupt changes in the mesons properties with gap sizes regulated by the phenomenological gluonic sector of the model.

Published
2024
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2. Dark matter effects on hybrid star properties

Author

C. H. Lenzi, M. Dutra, O. Lourenço, L. L. Lopes, and D. P. Menezes

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract In the present work, we investigate the effects of dark matter (DM) on hybrid star properties. We assume that dark matter is mixed with both hadronic and quark matter and interacts with them through the exchange of a Higgs boson. The hybrid star properties are obtained from equations of state calculated with a Maxwell prescription. For the hadronic matter, we use the NL3* parameter set, and for the quark matter, the MIT bag model with a vector interaction. We see that dark matter does not influence the phase transition points (pressure and chemical potential) but shifts the discontinuity on the energy density, which ultimately reduces the minimum mass star that contains a quark core. Moreover, it changes considerably the star family mass-radius diagrams and moves the merger polarizability curves inside the confidence lines. Another interesting feature is the influence of DM in the quark core of the hybrid stars constructed. Our results show an increase of the core radius for higher values of the dark particle Fermi momentum.

Published
2023
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3. Thermodynamical phases in a PNJL model at zero temperature

Author

O. A. Mattos, T. Frederico, and O. Lourenço

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The confinement/deconfinement transition described the Polyakov–Nambu–Jona–Lasinio (PNJL) model is extended to be operative at zero temperature regime. In this study, the scalar and vector channel interaction strengths of the original PNJL model are modified by introducing a dependence on the traced Polyakov loop. In such a way the effective interactions depend on the quark phase and in turn provides a backreaction of the quarks to the gluonic sector, also at zero temperature. On general grounds from quantum chromodynamics this is an expected feature. The thermodynamics of the extended model (PNJL0) is studied in detail. It presents along with a suitable choice of the Polyakov potential, a first order confined/deconfined quark phase transition even at $$T=0$$ T = 0 . We also show that the vector channel plays an important role in order to allow $$\varPhi \ne 0$$ Φ ≠ 0 solutions for the PNJL0 model. Furthermore, the sensitivity of the combined quarkyonic and deconfinement phases to the vector interaction strength and the proposed parametrization of the Polyakov-loop potential at $$T=0$$ T = 0 allowed to set a window for the bulk values of the relevant parameters.

Published
2021
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4. Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma

Author

J. Bousquet, A. Bedbrook, W. Czarlewski, G. L. Onorato, S. Arnavielhe, D. Laune, E. Mathieu-Dupas, J. Fonseca, E. Costa, O. Lourenço, M. Morais-Almeida, A. Todo-Bom, M. Illario, E. Menditto, G. W. Canonica, L. Cecchi, R. Monti, L. Napoli, M. T. Ventura, G. De Feo, W. J. Fokkens, N. H. Chavannes, S. Reitsma, A. A. Cruz, J. da Silva, F. S. Serpa, D. Larenas-Linnemann, J. M. Fuentes Perez, Y. R. Huerta-Villalobos, D. Rivero-Yeverino, E. Rodriguez-Zagal, A. Valiulis, R. Dubakiene, R. Emuzyte, V. Kvedariene, I. Annesi-Maesano, H. Blain, P. Bonniaud, I. Bosse, Y. Dauvilliers, P. Devillier, J. F. Fontaine, J. L. Pépin, N. Pham-Thi, F. Portejoie, R. Picard, N. Roche, C. Rolland, P. Schmidt-Grendelmeier, P. Kuna, B. Samolinski, J. M. Anto, V. Cardona, J. Mullol, H. Pinnock, D. Ryan, A. Sheikh, S. Walker, S. Williams, S. Becker, L. Klimek, O. Pfaar, K. C. Bergmann, R. Mösges, T. Zuberbier, R. E. Roller-Wirnsberger, P. V. Tomazic, T. Haahtela, J. Salimäki, S. Toppila-Salmi, E. Valovirta, T. Vasankari, B. Gemicioğlu, A. Yorgancioglu, N. G. Papadopoulos, E. P. Prokopakis, I. G. Tsiligianni, S. Bosnic-Anticevich, R. O’Hehir, J. C. Ivancevich, H. Neffen, M. E. Zernotti, I. Kull, E. Melén, M. Wickman, C. Bachert, P. W. Hellings, G. Brusselle, S. Palkonen, C. Bindslev-Jensen, E. Eller, S. Waserman, L. P. Boulet, J. Bouchard, D. K. Chu, H. J. Schünemann, M. Sova, G. De Vries, M. van Eerd, I. Agache, I. J. Ansotegui, M. Bewick, T. Casale, M. Dykewick, M. Ebisawa, R. Murray, R. Naclerio, Y. Okamoto, D. V. Wallace, and The MASK study group

Subjects
App, Asthma, Care pathways, MASK, mHealth, Rhinitis, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Aims Mobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurred by the disease and to improve the digital transformation of health and care. The ultimate goal is to change the management strategy in chronic diseases. Methods MASK implements ICT technologies for individualized and predictive medicine to develop novel care pathways by a multi-disciplinary group centred around the patients. Stakeholders Include patients, health care professionals (pharmacists and physicians), authorities, patient’s associations, private and public sectors. Results MASK is deployed in 23 countries and 17 languages. 26,000 users have registered. EU grants (2018) MASK is participating in EU projects (POLLAR: impact of air POLLution in Asthma and Rhinitis, EIT Health, DigitalHealthEurope, Euriphi and Vigour). Lessons learnt (i) Adherence to treatment is the major problem of allergic disease, (ii) Self-management strategies should be considerably expanded (behavioural), (iii) Change management is essential in allergic diseases, (iv) Education strategies should be reconsidered using a patient-centred approach and (v) Lessons learnt for allergic diseases can be expanded to chronic diseases.

Published
2019
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5. GW170817 constraints analyzed with Gogny forces and momentum-dependent interactions

Author

O. Lourenço, M. Bhuyan, C.H. Lenzi, M. Dutra, C. Gonzalez-Boquera, M. Centelles, and X. Viñas

Subjects
Physics, QC1-999
Abstract

A set of equations of state obtained from finite-range Gogny forces and momentum-dependent interactions is used to investigate the recent observation of gravitational waves from the binary neutron star merger GW170817 event. For this set of interactions, we have calculated the neutron star tidal deformabilities (related to the second Love number), the mass-radius diagram, and the moment of inertia (I). The I-Love relation has been verified. We also have found strong correlations among the tidal deformability of the canonical neutron star, its radius, and the derivatives of the nuclear symmetry energy at the saturation density. Most of the obtained results are located within the constraints of the tidal deformabilities extracted from the GW170817 detection. Keywords: Equation of state, Finite-range interactions, Neutron star, Tidal deformability, Moment of inertia

Published
2020
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6. The holographic paradigm of hadron dynamics for medium modified nuclear matters

Author

W. de Paula, Chueng-Ryong Ji, J.P.B.C. de Melo, T. Frederico, and O. Lourenço

Subjects
Physics, QC1-999
Abstract

We propose a medium-modified holographic-hadron dynamics suitable for the study of symmetric nuclear matter, with a key property of a simple law for the evolution of the five dimensional mass with the scalar background field. We show that the model satisfies symmetric nuclear matter constraints, namely, incompressibility and density dependence of the pressure, with only three free adjustable parameters fitted to the free nucleon mass and the nuclear matter saturation properties. We found that the holographic nucleon swells and the UV behavior of the associated string amplitude is damped, with the scaling property at short distances softened. Both effects can also generate observable consequences reflecting an average leakage of partons to the nuclear medium when density is increased, in the route towards the deconfinement of the internal nucleon degrees of freedom. Keywords: AdS/QCD models, Nuclear matter, Equations of state

Published
2020
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7. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry

Author

Jitendra PS. Sawhney, Veerappa A. Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S. Pieper, A. John Camm, Ajay K. Kakkar, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Gloria Kayani, Keith A.A. Fox, Bernard J. Gersh, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, Alex Spyropoulos, John Eikelboom, Ramon Corbalan, Dayi Hu, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Sanjay Kakkar, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, D.Y. Hu, K.N. Chen, Y.S. Zhao, H.Q. Zhang, J.Z. Chen, S.P. Cao, D.W. Wang, Y.J. Yang, W.H. Li, Y.H. Yin, G.Z. Tao, P. Yang, Y.M. Chen, S.H. He, Ying Wang, Yong Wang, G.S. Fu, X. Li, T.G. Wu, X.S. Cheng, X.W. Yan, R.P. Zhao, M.S. Chen, L.G. Xiong, P. Chen, Y. Jiao, Y. Guo, L. Xue, F.Z. Wang, H. Li, Z.M. Yang, C.L. Bai, J. Chen, J.Y. Chen, X. Chen, S. Feng, Q.H. Fu, X.J. Gao, W.N. Guo, R.H. He, X.A. He, X.S. Hu, X.F. Huang, B. Li, J. Li, L. Li, Y.H. Li, T.T. Liu, W.L. Liu, Y.Y. Liu, Z.C. Lu, X.L. Luo, T.Y. Ma, J.Q. Peng, X. Sheng, X.J. Shi, Y.H. Sun, G. Tian, K. Wang, L. Wang, R.N. Wu, Q. Xie, R.Y. Xu, J.S. Yang, L.L. Yang, Q. Yang, Y. Ye, H.Y. Yu, J.H. Yu, T. Yu, H. Zhai, Q. Zhan, G.S. Zhang, Q. Zhang, R. Zhang, Y. Zhang, W.Y. Zheng, B. Zhou, Z.H. Zhou, X.Y. Zhu, S. Kakkar, J.P.S. Sawhney, P. Jadhav, R. Durgaprasad, A.G. Ravi Shankar, R.K. Rajput, K. Bhargava, R. Sarma, A. Srinivas, D. Roy, U.M. Nagamalesh, M. Chopda, R. Kishore, G. Kulkarni, P. Chandwani, R.A. Pothiwala, M. Padinhare Purayil, S. Shah, K. Chawla, V.A. Kothiwale, B. Raghuraman, G. Vijayaraghavan, V.M. Vijan, G. Bantwal, V. Bisne, A. Khan, J.B. Gupta, S. Kumar, D. Jain, S. Abraham, D. Adak, A. Barai, H. Begum, P. Bhattacharjee, M. Dargude, D. Davies, B. Deshpande, P. Dhakrao, V. Dhyani, S. Duhan, M. Earath, A. Ganatra, S. Giradkar, V. Jain, R. Karthikeyan, L. Kasala, S. Kaur, S. Krishnappa, A. Lawande, B. Lokesh, N. Madarkar, R. Meena, P. More, D. Naik, K. Prashanth, M. Rao, N.M. Rao, N. Sadhu, D. Shah, M. Sharma, P. Shiva, S. Singhal, S. Suresh, V. Vanajakshamma, S.G. Panse, Y. Koretsune, S. Kanamori, K. Yamamoto, K. Kumagai, Y. Katsuda, K. Sadamatsu, F. Toyota, Y. Mizuno, I. Misumi, H. Noguchi, S. Ando, T. Suetsugu, M. Minamoto, Hiroshi Oda, K. Shiraishi, S. Adachi, K. Chiba, H. Norita, M. Tsuruta, T. Koyanagi, H. Ando, T. Higashi, K. Okada, S. Azakami, S. Komaki, K. Kumeda, T. Murayama, J. Matsumura, Y. Oba, R. Sonoda, K. Goto, K. Minoda, Y. Haraguchi, H. Suefuji, H. Miyagi, H. Kato, Tadashi Nakamura, Tsugihiro Nakamura, H. Nandate, R. Zaitsu, Yoshihisa Fujiura, A. Yoshimura, H. Numata, J. Ogawa, H. Tatematsu, Y. Kamogawa, K. Murakami, Y. Wakasa, M. Yamasawa, H. Maekawa, S. Abe, H. Kihara, S. Tsunoda, Katsumi Saito, Kazuyuki Saito, T. Fudo, K. Obunai, H. Tachibana, I. Oba, T. Kuwahata, S. Higa, M. Gushiken, T. Eto, H. Yoshida, D. Ikeda, Yoshitake Fujiura, M. Ishizawa, M. Nakatsuka, K. Murata, C. Ogurusu, M. Shimoyama, M. Akutsu, I. Takamura, F. Hoshino, N. Yokota, T. Iwao, K. Tsuchida, M. Takeuchi, Y. Hatori, Y. Kitami, Yoichi Nakamura, R. Oyama, M. Ageta, Hiroyuki Oda, Y. Go, K. Mishima, T. Unoki, S. Morii, Yuhei Shiga, H. Sumi, T. Nagatomo, K. Sanno, K. Fujisawa, Y. Atsuchi, T. Nagoshi, T. Seto, T. Tabuchi, M. Kameko, K. Nii, K. Oshiro, H. Takezawa, S. Nagano, N. Miyamoto, M. Iwaki, Yuichiro Nakamura, M. Fujii, M. Okawa, Masahiko Abe, Masatake Abe, Mitsunori Abe, T. Saito, T. Mito, K. Nagao, J. Minami, T. Mita, I. Sakuma, T. Taguchi, S. Marusaki, H. Doi, M. Tanaka, T. Fujito, M. Matsuta, T. Kusumoto, S. Kakinoki, K. Ashida, N. Yoshizawa, J. Agata, O. Arasaki, M. Manita, M. Ikemura, S. Fukuoka, H. Murakami, S. Matsukawa, Y. Hata, T. Taniguchi, T. Ko, H. Kubo, M. Imamaki, M. Akiyama, M. Inagaki, H. Odakura, T. Ueda, Y. Katsube, A. Nakata, H. Watanabe, M. Techigawara, M. Igarashi, K. Taga, T. Kimura, S. Tomimoto, M. Shibuya, M. Nakano, K. Ito, T. Seo, S. Hiramitsu, H. Hosokawa, M. Hoshiai, M. Hibino, K. Miyagawa, Hajime Horie, N. Sugishita, Yukio Shiga, A. Soma, K. Neya, Tetsuro Yoshida, Tomoki Yoshida, M. Mizuguchi, M. Ishiguro, T. Minagawa, M. Wada, H. Mukawa, F. Okuda, S. Nagasaka, Y. Abe, Sen Adachi, Susumu Adachi, T. Adachi, K. Akahane, T. Amano, K. Aoki, T. Aoyama, H. Arai, S. Arima, T. Arino, H. Asano, T. Asano, J. Azuma, T. Baba, T. Betsuyaku, H. Chibana, H. Date, J. Doiuchi, Y. Emura, M. Endo, Y. Fujii, R. Fujiki, A. Fujisawa, Y. Fujisawa, T. Fukuda, T. Fukui, N. Furukawa, T. Furukawa, W. Furumoto, T. Goto, M. Hamaoka, N. Hanazono, K. Hasegawa, T. Hatsuno, Y. Hayashi, K. Higuchi, K. Hirasawa, H. Hirayama, M. Hirose, S. Hirota, M. Honda, Hideki Horie, T. Ido, O. Iiji, H. Ikeda, K. Ikeda, K. Ikeoka, M. Imaizumi, H. Inaba, T. Inoue, F. Iseki, A. Ishihara, N. Ishioka, N. Ito, T. Iwase, H. Kakuda, J. Kamata, H. Kanai, H. Kanda, M. Kaneko, H. Kano, T. Kasai, T. Kato, Y. Kato, Y. Kawada, K. Kawai, K. Kawakami, S. Kawakami, T. Kawamoto, S. Kawano, J. Kim, T. Kira, H. Kitazawa, H. Kitazumi, T. Kito, T. Kobayashi, T. Koeda, J. Kojima, H. Komatsu, I. Komatsu, Y. Koshibu, T. Kotani, T. Kozuka, Y. Kumai, T. Kumazaki, I. Maeda, K. Maeda, Y. Maruyama, S. Matsui, K. Matsushita, Y. Matsuura, K. Mineoi, H. Mitsuhashi, N. Miura, S. Miyaguchi, S. Miyajima, H. Miyamoto, A. Miyashita, S. Miyata, I. Mizuguchi, A. Mizuno, T. Mori, O. Moriai, K. Morishita, O. Murai, Sho Nagai, Shunichi Nagai, E. Nagata, H. Nagata, A. Nakagomi, S. Nakahara, M. Nakamura, R. Nakamura, N. Nakanishi, T. Nakayama, R. Nakazato, T. Nanke, J. Nariyama, Y. Niijima, H. Niinuma, Y. Nishida, Y. Nishihata, K. Nishino, H. Nishioka, K. Nishizawa, I. Niwa, K. Nomura, S. Nomura, M. Nozoe, T. Ogawa, N. Ohara, M. Okada, K. Okamoto, H. Okita, M. Okuyama, H. Ono, T. Ono, Y. Onuki Pearce, S. Oriso, A. Ota, E. Otaki, Y. Saito, H. Sakai, N. Sakamoto, Y. Sakamoto, Y. Samejima, Y. Sasagawa, H. Sasaguri, A. Sasaki, T. Sasaki, Kazuki Sato, Kiyoharu Sato, M. Sawano, S. Seki, Y. Sekine, Y. Seta, K. Sezaki, N. Shibata, Y. Shiina, H. Shimono, Y. Shimoyama, T. Shindo, H. Shinohara, R. Shinohe, T. Shinozuka, T. Shirai, T. Shiraiwa, Y. Shozawa, T. Suga, C. Sugimoto, Kazuo Suzuki, Keita Suzuki, Shu Suzuki, Shunji Suzuki, Susumu Suzuki, Y. Suzuki, M. Tada, A. Taguchi, T. Takagi, Y. Takagi, K. Takahashi, S. Takahashi, H. Takai, C. Takanaka, S. Take, H. Takeda, K. Takei, K. Takenaka, T. Tana, G. Tanabe, K. Taya, H. Teragawa, S. Tohyo, S. Toru, Y. Tsuchiya, T. Tsuji, K. Tsuzaki, H. Uchiyama, O. Ueda, Y. Ueyama, N. Wakaki, T. Wakiyama, T. Washizuka, M. Watanabe, T. Yamada, T. Yamagishi, H. Yamaguchi, Kenichi Yamamoto, Kentaro Yamamoto, Kunihiko Yamamoto, T. Yamamoto, M. Yamaura, M. Yamazoe, K. Yasui, Y. Yokoyama, K. Yoshida, T.W. Lim, C.K. Ching, C.G. Foo, J.H. Chow, D.D. Chen, F.R. Jaufeerally, Y.M. Lee, G. Lim, W.T. Lim, S. Thng, S.Y. Yap, C. Yeo, S. Oh, H.N. Pak, J.-B. Kim, J.H. Kim, S.-W. Jang, D.H. Kim, D.R. Ryu, S.W. Park, D.-K. Kim, D.J. Choi, Y.S. Oh, M.-C. Cho, S.-H. Kim, H.-K. Jeon, D.-G. Shin, J.S. Park, H.K. Park, S.-J. Han, J.H. Sung, J.-G. Cho, G.-B. Nam, Y.K. On, H.E. Lim, J.J. Kwak, T.-J. Cha, T.J. Hong, S.H. Park, J.H. Yoon, N.-H. Kim, K.-S. Kim, B.C. Jung, G.-S. Hwang, C.-J. Kim, D.B. Kim, J.J. Ahn, H.J. An, H. Bae, A.L. Baek, W.J. Chi, E.A. Choi, E.H. Choi, H.K. Choi, H.S. Choi, S. Han, E.S. Heo, K.O. Her, S.W. Hwang, E.M. Jang, H.-S. Jang, S. Jang, H.-G. Jeon, S.R. Jeon, Y.R. Jeon, H.K. Jeong, I.-A. Jung, Hyeon Jeong Kim, Hyun Ju Kim, Ji Seon Kim, Jung Sook Kim, J.A. Kim, K.T. Kim, M.S. Kim, Sang Hee Kim, Sang Hyun Kim, Y.-I. Kim, C.S. Lee, E.H. Lee, G.H. Lee, H.Y. Lee, H.-Y. Lee, K.H. Lee, K.R. Lee, M.S. Lee, M.-Y. Lee, R.W. Lee, S.E. Lee, S.H. Lee, S. Lee, W.Y. Lee, I.K. Noh, A.R. Park, B.R. Park, H.N. Park, J.H. Park, M. Park, Y. Park, S.-Y. Seo, J. Shim, J.H. Sim, Y.M. Sohn, W.S. Son, Y.S. Son, H.J. Song, H.K. Wi, J.J. Woo, S. Ye, K.H. Yim, K.M. Yoo, E.J. Yoon, S.Y. Yun, P. Angchaisuksiri, S. Chawanadelert, P. Mongkolwongroj, K. Kanokphatcharakun, S. Cheewatanakornkul, T. Laksomya, S. Pattanaprichakul, T. Chantrarat, S. Rungaramsin, S. Silaruks, W. Wongcharoen, K. Siriwattana, K. Likittanasombat, P. Katekangplu, W. Boonyapisit, D. Cholsaringkarl, B. Chatlaong, P. Chattranukulchai, Y. Santanakorn, P. Hutayanon, P. Khunrong, T. Bunyapipat, S. Jai-Aue, P. Kaewsuwanna, P. Bamungpong, S. Gunaparn, S. Hongsuppinyo, R. Inphontan, R. Khattaroek, K. Khunkong, U. Kitmapawanont, C. Kongsin, B. Naratreekoon, S. Ninwaranon, J. Phangyota, A. Phrommintikul, P. Phunpinyosak, K. Pongmorakot, S. Poomiphol, N. Pornnimitthum, S. Pumprueg, S. Ratchasikaew, K. Sanit, K. Sawanyawisuth, B. Silaruks, R. Sirichai, A. Sriwichian, W. Suebjaksing, P. Sukklad, T. Suttana, A. Tangsirira, O. Thangpet, W. Tiyanon, Y. Vorasettakarnkij, T. Wisaratapong, W. Wongtheptien, A. Wutthimanop, S. Yawila, A. Oto, A. Altun, I. Ozdogru, K. Ozdemir, O. Yilmaz, A. Aydinlar, M.B. Yilmaz, E. Yeter, Z. Ongen, M. Cayli, H. Pekdemir, M. Ozdemir, M. Sucu, T. Sayin, M. Demir, H. Yorgun, M. Ersanli, E. Okuyan, D. Aras, H. Abdelrahman, O. Aktas, D. Alpay, F. Aras, M.F. Bireciklioglu, S. Budeyri, M. Buyukpapuc, S. Caliskan, M. Esen, M.A. Felekoglu, D. Genc, B. Ikitimur, E.B. Karaayvaz, S. Kılıç Karataş, S. Okutucu, E. Ozcelik, A. Quisi, H. Sag, L. Sahiner, B.Y. Sayin, T. Seker, D. Uzun Alkan, E. Yildirim, R. Yildirim, F. Yilmaz, V. Yuksekdag, H.L. Luciardi, N. Vensentini, A.C. Ingaramo, G.A. Sambadaro, V. Fernandez Caputi, S.G. Berman, P. Dragotto, A.J. Kleiban, N. Centurion, G. Giacomi, R.A. Ahuad Guerrero, D. Conde, G. Zapata, L.A. Di Paola, J.L. Ramos, R.D. Dran, J. Egido, A.A. Fernandez, M.J. Fosco, S. Sassone, V.A. Sinisi, L.R. Cartasegna, M.A. Berli, O.A. Gomez Vilamajo, F. Ferroni, E.D. Alaguibe, A. Alvarez D'Amelio, C. Arabetti, L. Arias, J.A. Belardi, L. Bergesio, F. Berli, M. Berli, S. Borchowiec, C. Buzzetti, R. Cabrini, V. Campisi, A.L. Cappi, R. Carrizo, F. Colombo Berra, J.P. Costabel, O.J.A. Costamagna, A.A. Damonte, I.N. De Urquiza, F. Diez, M.F. Edén, M. Fanuele, F. Fernandez Voena, M. Foa Torres, C. Funosas, M.P. Giacomi, C.H. Gimenez, E.P. Gurfinkel, M. de L.M. Had, V. Hansen, A.D. Hrabar, M. Ingratta, A. Lopez, G. Maehara, L. Maffei, A. Martinelli, C. Martinelli, J. Matkovich, B. Mautner, A. Meirino, R. Munguia, A. Navarro, V. Novas, G. Perez Prados, J. Pontoriero, R.N. Potito, C. Ricotti, M.A. Rodriguez, F. Rolandi, M.E. Said Palladino, M. Salinger, L.S. Sanziani, P.O. Schygiel, A. Sossich, J.F. Tinto, L. Tonelli, A.L. Tufare, M. Vallejo, M.E. Yunis, M. Zillo, F.J. Zurbrigk, A.C.P. Barretto, D.C. Sobral Filho, J. Jaber, D. Armaganijan, J. Faria Neto, A. Steffens, W. Kunz Sebba Barroso de Souza, J.D. de Souza Neto, J.M. Ribeiro, M. Silveira Teixeira, P.R. Ferreira Rossi, L. Pires, D. Moreira, J.C. Moura Jorge, A. Menezes Lorga Filho, L.C. Bodanese, M. Westerlund Montera, C.H. Del Carlo, T. Da Rocha Rodrigues, F.A. Alves da Costa, A. Lopes, R. Lopes, G.R. Araújo, E.R. Fernandes Manenti, J.F. Kerr Saraiva, J.C. Ferreira Braga, A. Negri, L. Souto, C. Moncada, D. Bertolim Precoma, F. Roquette, G. Reis, R.A. Ramos Filho, E. Lanna Figueiredo, R. Vieira Botelho, C. Munhoz da Fontoura Tavares, C.R. Costantini Frack, J. Abdalla Saad, H.C. Finimundi, C. Pisani, D. Chemello, M. Pereira Martins, C.C. Broilo França, F. Alban, G.B. Aranha Rosito, J.B. de Moura Xavier Moraes Junior, R.T. Tumelero, L. Nigro Maia, R. Simões de Almeida, N.C. do Carmo Borges, L.G. Gomes Ferreira, P. Agliardi, J. Alves de Oliveira Gomes, V. Araujo, M. Arruda Nakazone, T. Barbosa, S. Barroso, E. Belisario Falchetto, H. Bellotti Lopes, M.A. Benez Teixeira Lemos, G. Biazus, L. Borges Queiroz, F.E. Camazzola, M. Caporale, S. Cardoso Boscato, F. Chieza, M.O. Chokr, R. Clemente Mingireanov, N. Codonho Góes, C. Correa, M. Costa, C. Costantini Ortiz, L.S. da Silva, F. da Silva Paulitsch, J.A. da Silveira, E. Daros, G.R. de Araújo, M.I. Del Monaco, C. Dias, M.A. Dias, A.P. Drummond Wainstein, P. Ely Pizzato, D.C. Esteves, P. Fabri, T. Félix Lorenzato Fonseca, E. Fernandes, C. Fonseca, C.R. Frack Costantini, R. Franchin Ferraz, F. Freire, P. Gottardo, D. Guanaes, S. Guizzardi, E. Hettwer Magedanz, F. Igansi, F. Jannuzzi, G. Junior, D. Komar, E.G. Lino, D. Lopes, O. Lourenço da Silva Júnior, E. Lustosa, A.P. Macagnan, M.C. Marinho, M. Mazzoni, G. Melo, L. Mortari, O.M.C.C. Mouco, C. Nanzer Vital, C. Ormundo, S. Oss Emmer, E. Palmegiani, R. Pavani, L. Pereira, V.L. Pereira, R. Perreira, S. Poletti, S.C. Quaia Fortunato, C. Queirantes, N. Ramos Pereira, R.L. Rech, S. Ribeiro, A. Rodrigues, H. Roesch, T. Ruaro Reichert, D. Santos, I. Santos, M. Santos, M.V. Seroqui, S. Silva, L. Soares, L. Spolaor, C. Stoll, N. Toazza Duda, L. Trama, B. Unterkircher, M.V. Valois, T. Vargas, T. Viana, C. Vicente, L. Vidal Armaganijan, R. Vieira Homem, L.G. Vieira Torres, L. Vila Boas, F. Villaça Guimarães Filho, R. Corbalan, G. Eggers, C. Bugueño Gutiérrez, G. Arriagada, S. Potthoff Cardenas, B.A.J. Stockins Fernandez, C. Conejeros, C. Houzvic, P. Marin Cuevas, H. Montecinos, A. Forero, F. Lanas, M. Larico Gómez, G. Charme Vilches, C. Rey, C. Astudillo, J. Aguilar, Y. Campisto, C. Lara, E. Molina, J. Munoz Oyarzon, V. Olguin, M. Vergara, C. Villan, C.J. Sánchez Díaz, J. Illescas Diaz, R. Leal Cantú, M.G. Ramos Zavala, R. Cabrera Jardines, N. Espinola Zavaleta, S. Villarreal Umaña, E. López Rosas, G. Llamas Esperón, G. Pozas, E. Cardona Muñoz, N. Matadamas Hernández, A. Leyva Rendón, N. García Hernández, M. de los Ríos Ibarra, L. Virgen Carrillo, D. López Villezca, C. Hernández Herrera, J.J. López Prieto, R. Gaona Rodríguez, E. Villeda Espinosa, D. Flores Martínez, J. Velasco Barcena, R. Yong, I. Rodríguez Briones, J.L. Leiva Pons, H. Álvarez López, R. Olvera Ruiz, C. Díaz de la Vega, C. Cantú Brito, E. Chuquiure Valenzuela, R. Reyes-Sanchez, A. Bazzoni Ruiz, O. Nandayapa Flores, M. Benavides Gonzalez, R. Arriaga Nava, J.D. Morales Cerda, O. Fierro Fierro, P. Fajardo Campos, T.A.A. Alfaro, S. Altamirano Bellorin, R. Avena, M. Chavarria, I. Espinosa, F. Flores Silva, R.H. Garcia Nava, K. Godoy, E.J. Gonzalez Felix, C.L. Gonzalez Garcia, L.G. Gonzalez Salas, P. Guajardo, S. Hernandez Gonzalez, T. Izquierdo, M.C. Mancilla Ortiz, D. Martinez Vasquez, N. Mendoza, J. Morales, N. Nikitina, S. Ochoa Aybar, A. Ortiz, P. Padilla Macias, F. Perez, J.A. Perez Sanchez, S. Piña Toledano, M. Ramos Gonzalez, C. Rivera Ramos, V. Roa Castro, G. Romero Cardona, M. Ruiz Cornejo, A. Salinas, G. Santana, P. Sida Perez, A.C. Tovar Castaneda, R. Trujillo Cortes, M. Brodmann, K. Lenz, H. Drexel, J. Foechterle, C. Hagn, A. Podczeck-Schweighofer, K. Huber, M. Winkler, B. Schneeweiß, A. Gegenhuber, W. Lang, S. Eichinger-Hasenauer, P. Kaserer, J. Sykora, H. Rasch, M. Pichler, E. Schaflinger, B. Strohmer, R. Breier, K.-M. Ebner, L. Eischer, F. Freihoff, A. Lischka-Lindner, T. Mark, A. Mirtl, A. Said, C. Stöcklöcker, B. Vogel, A. Vonbank, C. Wöhrer, D. Zanolin, F. Cools, G. Paparella, P. Vandergoten, J.-L. Parqué, L. Capiau, G. Vervoort, B. Wollaert, P. Desfontaines, G. Mairesse, T. Boussy, P. Godart, A. De Wolf, J. Voet, A. Heyse, G. Hollanders, W. Anné, J. Vercammen, P. Purnode, I. Blankoff, D. Faes, Y. Balthazar, M. Beutels, P. Maréchal, S. Verstraete, O. Xhaet, H. Striekwold, J. Thoeng, K. Hermans, B. Alzand, A.-K. Ascoop, F. Banaeian, A.-M. Barbuto, A.C. Billiaux, M. Blockmans, C. Bouvy, C. Brike, H. Capiau, T. Casier, A. Conde Y Bolado, D. De Cleen, M. De Coninck, M. de Vos, N. de Weerdt, M. Delforge, M. Delvigne, D. Denie, K. Derycker, E. Deweerd, F. Dormal, S. Drieghe, M. Everaert, T. Eykerman, E. Feys, M. Ghekiere, F. Gits, S. Hellemans, L. Helvasto, C. Jacobs, S. Lips, I. Mestdagh, J. Nimmegeers, V. Piamonte, P. Pollet, A. Postolache, M. Raepers, E. Raymenants, J. Richa, H. Rombouts, J. Salembier, C. Scheurwegs, O. Semeraro, N. Simons, C. Smessaert, W. Smolders, I. Stockman, S. Tahon, V. Thyssen, G. Tincani, F. Van Durme, D. Van Lier, H. Vandekerckhove, Y. Vandekerckhove, D. Vandenbroeck, A. Vandorpe, E. Vanhalst, B. Vanhauwaert, C. Vantomme, L. Vergauwen, H. Verloove, T. Vydt, T. Weyn, P. Jansky, P. Reichert, R. Spacek, V. Machova, E. Zidkova, O. Ludka, J. Olsr, L. Kotik, K. Plocova, B. Racz, R. Ferkl, J. Hubac, I. Kotik, Z. Monhart, H. Burianova, O. Jerabek, J. Pisova, I. Petrova, V. Dedek, M. Honkova, P. Podrazil, J. Spinar, J. Vitovec, M. Novak, J. Lastuvka, V. Durdil, P. Antonova, L. Bockova, J. Bultas, J. Chlumsky, L. Dastychova, T. Drasnar, J. Honek, M. Horejsi, V. Hubacova, L. Janska, I. Kopeckova, R. Kratochvilova, E. Krcova, R. Labrova, A. Lindourkova, J. Lipoldova, H. Lubanda, A. Ludkova, L. Mahdalikova, M. Majerníkova, D. Michalik, P. Potuznik, E. Prochazkova, A. Sulc, J. Sveceny, M. Valtova, M. Zidek, J. Zika, J. Nielsen, H. Nielsen, S. Husted, U. Hintze, S. Rasmussen, A. Bremmelgaard, J. Markenvard, J. Boerger, J. Solgaard, P. Simonsen, T. Loekkegaard, M. Bruun, J. Mertz, H. Domínguez, K. Skagen, K. Egstrup, H. Ibsen, I. Raymond, T. Bang-Hansen, C. Ellervik, E. Eriksen, L. Jensen, M. Jensen, M. Leth, A. Nygaard, J. Park, M. Schou, A. Therkelsen, J. Tilma, K. Vesterager, P. Raatikainen, J. Airaksinen, O. Arola, J. Koistinen, H. Nappila, K. Peltomäki, V. Rasanen, T. Vasankari, J.-Y. Le Heuzey, M. Galinier, Y. Gottwalles, F. Paganelli, P. Loiselet, J.-J. Muller, M.B. Koujan, A. Marquand, S. Destrac, O. Piot, N. Delarche, J.-P. Cebron, S. Boveda, M. Guenoun, D. Guedj-Meynier, D. Galley, J. Ohayon, S. Assouline, M. Zuber, P. Amarenco, E. Ellie, J. Kadouch, P.-Y. Fournier, J.-P. Huberman, M. Lemaire, G. Rodier, L. Milandre, X. Vandamme, I. Sibon, J.-P. Neau, M.H. Mahagne, A. Mielot, M. Bonnefoy, J.-B. Churet, V. Navarre, F. Sellem, G. Monniot, J.-P. Boyes, B. Doucet, M. Martelet, D. Obadia, B. Crousillat, J. Mouallem, E. Bearez, P. Nazeyrollas, J.P. Brugnaux, A. Fedorowsky, F. Casassus, J.-B. Berneau, F. Chemin, N. Falvo, J.-M. Perron, J.-E. Poulard, A. Barreau, C. Beltra, E. Corrihons, N. Decarsin, B. Dubois, E. Ducasse, X. Giry, A. Kemmel, S. Ledure, N. Lemaire, F. Robin, N. Rosolin, D. Sanchez, A. Suissa, H. Darius, G. Königer, J. Purr, U. Gerbaulet, B.-T. Kellner, A. Kopf, T. Schäfer, H. Zauzig, P. Riegel, H. Hohensee, E. Eißfeller, W. Eder, G. Rehling, D. Glatzel, S. Zutz, G.-U. Heinz, H. Menke, A. Pustelnik, P. Sandow, N. Ludwig, H. Wiswedel, W. Wildenauer, C. Axthelm, T. Schwarz, A. Babyesiza, G. Stuchlik, H.-H. Zimny, M. Kropp, F. Kahl, A. Caspar, S. Omankowsky, T. Läßig, H.-J. Hartmann, G. Lehmann, H.-W. Bindig, G. Hergdt, D. Reimer, J. Hauk, W. Dorsch, J. Dshabrailov, H. Michel, K.-A. Rapp, R. Vormann, P. Mayer, U. Horstmeier, V. Eissing, H. Hey, H. Leuchtgens, V. Lilienweiß, K. Kolitsch, C. Schubert, H. Lauer, T. Buchner, G. Brauer, S. Kamin, K. Müller, M. Abdel-Qader, S. Baumbach, H.-H. Ebert, C. Schwencke, S. Schellong, P. Bernhardt, L. Karolyi, B. Sievers, W. Haverkamp, P. Salbach, J.-U. Röhnisch, S. Schoen, W. Erdle, T. Mueller, H. Mueller, V. Mitrovic, Z. Babjakova, K. Bergner, S. Boehme, K. Bonin, D. Buckert, F. Busch, U. Dichristin, S. Diez, A. Fleck, K. Flint, H. Floegel, C. Fritz, R. Frommhold, J. Gehre, J. Geyer, A. Grytzmann, M. Hahn, K. Helgert, K. Hubert, K. Kirchner-Volker, V. Klein, D. Kroll, A. Krueger, R. Lehmann, L. Mann, A. Maselli, G. Menken, K. Mikes, H. Mortan, N. Nasser, D. Nicolaus, A. Plauskat, L. Pomper, A. Quietzsch, C. Ravenhorst, C. Reichelt, C. Reimer, B. Schaefer, S. Scharrer, K. Schirmer, K. Schmidt, R. Schoene, J. Schulze, M. Schuppe, S. Simon, S. Sommer, K. Spranger, A. Talkenberger, K. Tauber, A. Tetlak, T. Toennishoff, R. Voelkel-Babyesiza, B. Voigts, U. Weiser, S. Wesendorf, S. Wildenauer, T. Wolf, J. Wurziger, J. Zak, H.-D. Zauzig, S. Ziefle, S. Zincke, M. Keltai, S. Vangel, G. Szalai, B. Merkely, S. Kancz, Z. Boda, A. Nagy, Z. Laszlo, A. Matoltsy, B. Gaszner, P. Polgar, T. Habon, E. Noori, G. Juhasz, N. Kanakaridisz, I. Szentpeteri, F. Juhasz, A. Vertes, A. Papp, Z. May, J. Ferenczi, M. Egyutt, E. Kis, G. Engelthaler, G. Szantai, E. Fulop, P. Gombos, D. Gulyas, P. Jen, E. Kiralyhazine Gyorke, M. Kovacs, S. Kovacsne Levang, S. Marianna, Z. Radics, N. Sydó, R. Szalo, A. Szilagyi, F. Sztanyik, B. Vandrus, G. Agnelli, G. Ambrosio, E. Tiraferri, R. Santoro, S. Testa, G. Di Minno, M. Moia, T.M. Caimi, G. Martini, M. Tessitori, R. Cappelli, D. Poli, R. Quintavalla, F. Melone, F. Cosmi, A. Pizzini, G. Piseddu, R. Fanelli, C. Latella, R. Santi, L. Pancaldi, R. De Cristofaro, G. Palareti, A. De Blasio, J. Salerno Uriarte, F. Minetti, E.M. Pogliani, L.M. Lonati, M. Accogli, N. Ciampani, S. Malengo, M. Feola, A. Raisaro, L. Fattore, P. Grilli, F. Germini, M. Settimi, M. Alunni, G. Duranti, L. Tedeschi, G. Baglioni, G. Avanzino, M. Berardi, V. Pannacci, A. Giombolini, S. Nicoli, T. Scarponi, B. Allasia, P. Ricciarini, R. Nasorri, A. Argena, P. Bossolasco, P. Ronchini, A. Filippi, F. Tradati, C. Bulla, L. Donzelli, L. Foppa, M.L. Bottarelli, A. Tomasello, A. Mauric, C. Femiano, R. Reggio, F. Lillo, A. Mariani, F. Forcignanò, M. Volpe, M. D'Avino, M.G. Bongiorni, S. Severi, A. Capucci, C. Lodigiani, E. Salomone, G. Serviddio, C. Tondo, P. Golino, C. Mazzone, S. Iacopino, V. Pengo, M. Galvani, L. Moretti, P. Ambrosino, E. Banfi, V. Biagioli, A. Bianchi, G. Boggian, M. Breschi, S. Brusorio, F. Calcagnoli, G. Campagna, M. Carpenedo, C. Ciabatta, G. Ciliberti, G. Cimmino, C. D'Arienzo, L. Di Gennaro, M. Fedele, P.M. Ferrini, K. Granzow, G. Guazzaloca, F. Guerra, A. Lo Buglio, S. Longo, F. Macellari, E. Mesolella, E. Mollica Poeta, P. Occhilupo, V. Oriana, G. Rangel, L. Salomone, A. Scaccianoce, C. Scarone, L. Segreti, G. Sottilota, R. Villani, C. Zecca, H. ten Cate, J.H. Ruiter, H. Klomps, M. Bongaerts, M.G.C. Pieterse, C. Guldener, J.-P. Herrman, G. Lochorn, A. Lucassen, H. Adriaansen, S.H.K. The, P.R. Nierop, P.A.M. Hoogslag, W. Hermans, B.E. Groenemeijer, W. Terpstra, C. Buiks, L.V.A. Boersma, M. Boersma-Slootweg, F. Bosman, M. Bosschaert, S. Bruin, I. Danse, J. De Graaf, J. de Graauw, M. Debordes, S. Dols, F. Geerlings, K. Gorrebeeck, A. Jerzewski, W. Jetten, M. Kelderman, T. Kloosterman, E.M. Koomen, J. Krikken, P. Melman, R. Mulder, A. Pronk, A. Stallinga-de Vos, J. te Kaat, P. Tonino, B. Uppelschoten, R. van de Loo, T. van der Kley, G. van Leeuwen, J.J. van Putten, L. Westerman, D. Atar, E. Berge, P.A. Sirnes, E. Gjertsen, T. Hole, K. Erga, A. Hallaråker, G. Skjelvan, A. Østrem, B. Ghezai, A. Svilaas, P. Christersson, T. Øien, S. Høegh Henrichsen, J. Berg-Johansen, J.E. Otterstad, H. Antonsen, K. Ausen, H. Claussen, I. Dominguez, A. Jekthammer, A.B. Lensebraaten, V. Nilsen, M. O'Donovan, K. Ringdalen, S. Strand, J. Stepinska, R. Korzeniak, A. Gieroba, M. Biedrzycka, Marcin Ogorek, B. Wozakowska-Kaplon, K. Loboz-Grudzien, J. Kosior, W. Supinski, J. Kuzniar, R. Zaluska, J. Hiczkiewicz, L. Swiatkowska-Byczynska, L. Kucharski, M. Gruchala, P. Minc, M. Olszewski, G. Kania, M. Krzciuk, Z. Lajkowski, B. Ostrowska-Pomian, J. Lewczuk, E. Zinka, A. Karczmarczyk, M. Chmielnicka-Pruszczynska, M. Trusz-Gluza, G. Opolski, M. Bronisz, Michal Ogorek, G. Glanowska, P. Ruszkowski, K. Jaworska, R. Sciborski, B. Okopien, P. Kukla, I. Wozniak-Skowerska, K. Galbas, K. Cymerman, J. Jurowiecki, P. Miekus, W. Myszka, S. Mazur, R. Lysek, J. Baszak, T. Rusicka-Piekarz, G. Raczak, E. Domanska, J. Nessler, J. Lesnik, M. Ambicka, D. Andrzejewski, J. Araminowicz, A. Barszcz, R. Bartkowiak, J. Bartnik, M. Basiak, E. Bekieszczuk, L. Bernat, L. Biedrzycki, A. Biernacka, D. Blaszczyk, E. Broton, W. Brzozowski, M. Brzustowska, R. Bzymek, A. Chmielowski, P. Chojnowski, R. Cichomski, K. Cieslak, A. Cieszynska, B. Curyllo, M. Czamara, L. Danilowicz-Szymanowicz, B. Dolecka, L. Drelich, B. Dudzik-Richter, T. Dybala, M. Dziuba, W. Faron, M. Figura-Chmielewska, A. Frankiewicz, W. Gadzinski, E. Gasior, B. Gosciniecka, P. Gutknecht, M. Guziewicz, A. Jackun-Podlesna, G. Jaguszewska, J. Jankielewicz, A. Jaremczuk-Kaczmarczyk, M. Jargiello-Baszak, A. Jarzebowski, E. Jaskulska-Niedziela, M. Jaworska-Drozdowska, J. Kabat, A. Kaczmarzyk-Radka, K. Kalin, R. Kaliszczak, M. Kiliszek, M. Klata, M. Kluczewski, I. Kobielusz-Gembala, E. Kochanska, D. Kociolek, A. Kolodzinska, A. Komlo, A. Konopka, E. Korczowska, E. Kowal, H.K. Kowalczyk, E. Kremis, D. Kruczyk, A. Krzesiak-Lodyga, M. Krzyzanowski, W. Kurdzielewicz, D. Kustrzycka-Kratochwil, D. Lesniewska-Krynska, J. Leszczynski, E. Lewicka, E. Lichota, K. Lip, M. Loboz-Rudnicka, J. Luka, A. Lysek-Jozefowicz, M. Machnikowska, K. Majewska, R. Mariankowski, A. Markiewicz, M. Mazur, A. Metzgier-Gumiela, E. Miedlar, M. Mielcarek, J. Neubauer-Geryk, J. Niedek, A. Niemirycz-Makurat, A. Nowak, S. Nowak, B. Opielowska-Nowak, M. Ozgowicz, A. Pawelska-Buczen, E. Pawlik-Rak, R. Piotrowicz, P. Ptaszynski, A. Raczynska, W. Rogowski, J. Romanek, R. Romaszkiewicz, P. Rostoff, N. Roszczyk, D. Rozewska-Furmanek, J. Rychta, B. Rzyczkowska, A. Sidor, J. Skalska, M. Smichura, M. Splawski, P. Staneta, E. Staniszewska, J. Starak-Marciniak, M. Stopyra-Poczatek, M. Sukiennik-Kujawa, J. Szafranski, P. Szalecki, A. Szczepanska, W. Szkrobka, E. Szuchnik, A. Szulowska, G. Szumczyk-Muszytowska, M. Szwoch, T. Traczyk, M. Troszczynska, G. Trzcinski, S. Tybura, P. Walasik, M. Wegrzynowska, K. Wesolowska, W. Wieczorek, A. Wierzbicka, P. Wilczewski, M. Wilgat-Szecowka, P. Wojewoda, L. Wojnowski, M. Wrobel, K. Zakutynska-Kowalczyk, M. Zyczynska-Szmon, E. Panchenko, V. Eltishcheva, R. Libis, S. Tereshchenko, S. Popov, G. Kamalov, D. Belenky, A. Zateyshchikova, E. Kropacheva, A. Kolesnikova, K. Nikolaev, L. Egorova, A. Khokhlov, E. Yakupov, M. Poltavskaya, D. Zateyshchikov, O. Drapkina, A. Vishnevsky, O. Barbarash, O. Miller, E. Aleksandrova, P. Chizhov, M. Sergeev, E. Shutemova, E. Mazur, K. Zrazhevskiy, T. Novikova, V. Kostenko, Y. Moiseeva, E. Polkanova, K. Sobolev, M. Rossovskaya, G. Zubeeva, Y. Shapovalova, O. Nagibovich, A. Edin, A. Agakhanyan, R. Batalov, Y. Belenkova, F. Bitakova, S. Chugunnaya, A. Dumikyan, S. Erofeeva, E. Gorbunova, T. Gorshkova, A. Gubanov, M. Gurmach, Y. Ivanova, T. Kolesova, D. Konyushenko, O. Korneeva, O. Kropova, P. Kuchuk, O. Kungurtseva, T. Kupriyanova, B. Kurylo, M. Kuvanova, O. Lebedeva, E. Lileeva, O. Machilskaya, T. Medvedeva, G. Monako, I. Motylev, G. Nagibovich, E. Novikova, Y. Orlov, Y. Osmolovskaya, A. Ovsannikova, D. Platonov, S. Rachkova, O. Sinitsina, S. Speshilova, O. Suslova, A. Ushakov, O. Volodicheva, O. Zemlianskaia, I. Zhirov, E. Zhuravleva, I. Zotova, X. Viñolas, P. Alvarez Garcia, M.F. López Fernández, L. Tercedor, S. Tranche Iparraguirre, P. Torán Monserrat, E. Márquez Contreras, J. Isart Rafecas, J. Motero Carrasco, P. García Pavía, C. Gómez Pajuelo, C. Moro Serrano, L.F. Iglesias Alonso, A. Grande Ruiz, J. Mercé Klein, J.R. Gonzalez Juanatey, G. Barón Esquivias, I. Monte Collado, H. Palacín Piquero, C. Brotons Cuixart, M. Rodríguez Morató, J. Bayo I Llibre, C. Corros Vicente, M. Vida Gutierrez, F. Epelde Gonzalo, C.A. Almeida Fernández, N. Del Val Plana, E. Escrivá Montserrat, J.J. Montero Alía, M. Barreda González, M.A. Moleiro Oliva, J. Iglesias Sanmartín, M. Jiménez González, M. Rodriguez Álvarez, J. Herreros Melenchon, T. Ripoll Vera, F. Ridocci Soriano, L. Garcia Riesco, M.D. Marco Macian, J. Quiles Granado, M. Jimenez Navarro, J. Cosin Sales, J.V. Vaquer Perez, M. Vazquez Caamano, M.F. Arcocha Torres, G. Marcos Gomez, A. Iñiguez Romo, M.A. Prieto Diaz, Carmela Alonso, Concepcion Alonso, D. Alvarez, M. Alvarez, M. Amaro, N. Andere, J. Aracil Villar, R. Armitano Ochoa, A. Austria, S. Barbeira, E. Barraquer Feu, A. Bartes, V. Becerra Munoz, F.J. Bermudez Jimenez, A. Branjovich Tijuan, J. Cabeza Ramirez, M. Cabrera Ramos, E. Calvo Martinez, M. Campo Moreno, G. Cancho Corchado, M. Casanova Gil, M. Castillo Orive, D. Castro Fernandez, M. Cebollada del Misterio, R. Codinachs Alsina, A. Cortada Cabrera, J. Costa Pinto Prego de Faria, S. Costas, M.I. Cotilla Marco, M. Dachs, C.M. Diaz Lopez, A. Domenech Borras, A. Elorriaga Madariaga, A. Espallargas, M. Fernandez, E. Fernandez Escobar, E. Fernandez Mas, A. Ferrer, J. Fosch, M. Garcia Bermudez, V. Garcia Millan, M. Gavira Saenz, C. Gines Garcia, C. Gomez, Y. Gomez Perez, A. Gonzales Segovia, P. Gonzalez, L. Grigorian, A. Guerrero Molina, M. del C. Gutierrez del Val, B. Herrero Maeso, E. Hevia Rodriguez, A. Iglesias Garcia, M.J. Jimenez Fernandez, B. Jimeno Besa, P. Juan Salvadores, M.B. Lage Bouzamayor, I. Lasuncion, L.E. Lezcano Gort, M. Llobet Molina, M. Lopez, A. Manzanal Rey, J. Mara Guerra, S. Marcus, A. Martin Vila, M. Martinez Mena, P. Mazon, F. Mendez Zurita, G. Millán, M. Molina, P. Montero Alia, D. Montes, M. Moure Gonzalez, R.B. Munoz Munoz, A. Negrete Palma, H.N. Orellana Figueroa, V.M. Ortega, C. Ortiz Cortes, D. Otero Tomera, N. Palomo Merchan, I. Pareja Ibar, E. Pena Garcia, M. Pereda Armayor, M. Perez Carasa, I. Prieto, V. Quintern, R. Renom, L.M. Rincon Diaz, V. Rios, L. Riquelme Sola, R. Rivera, X. Robiro Robiro, M. Roca, C. Roca Saumell, C. Rodrigo, E. Rodriguez, M. Rodriguez Garcia, S. Saez Jimenez, P. Sanchez Calderon, L. Sanchez Mendez, S. Sanchez Parra, C. Santolaya, M.R. Senan Sanz, A. Seoane Blanco, E. Serralvo, N. Sierra, C. Simon Valero, J. Sorribes Lopez, M. Teixido Fontanillas, M. Terns Riera, G. Tobajas, C. Torres, J. Torres Marques, M. Ubeda Pastor, M. Rosenqvist, A. Wirdby, J. Linden, K. Henriksson, M. Elmersson, A. Egilsson, U. Börjesson, G. Svärd, B. Liu, A. Lindh, L.-B. Olsson, M. Gustavsson, Lars Andersson, Lisbeth Andersson, L. Benson, C. Bothin, A. Hajimirsadeghi, K. Kadir, M. Ericsson, A. Ohlsson, H. Lindvall, P. Svensson, K. Thorne, H. Handel, P. Platonov, B. Eriksson, I. Timberg, K. Romberg, M. Crisby, J.-E. Karlsson, S.A. Jensen, A. Andersson, L. Malmqvist, B. Martinsson, F. Bernsten, J. Engdahl, J. Thulin, A. Hot-Bjelac, P. Stalby, H. Aaröe, E. Ahbeck, H. Ahlmark, F. Al-Khalili, G. Bonkowski, S. Dzeletovic, A.-B. Ekstrand, G.-B. Eriksson, K. Floren, C. Grässjö, S. Hahn, P. Jaensson, B. Jansson, J.-H. Jansson, R.-M. Kangert, A. Koch, D. Kusiak, A. Lettenström, A. Lindberg, C.-J. Lindholm, A. Mannermyr, K. Mansson, M. Millborg, C. Nilsson, A.-M. Ohlin, A. Olofsson, A. Osberg, A. Pedersen, K. Risbecker, K. Rosenberg, J. Samuelsson, M. Shayesteh, K. Skoglund, M. Stjernberg, C. Thorsen, J. Steffel, J.H. Beer, J. Debrunner, D. Amstutz, J. Bruegger, G. Elise, A. Grau, A. Guinand, I. Henriette, E. Saga, S. Winnik, A. Parkhomenko, I. Rudyk, V. Tseluyko, O. Karpenko, S. Zhurba, I. Kraiz, I. Kupnovytska, N. Serediuk, Y. Mostovoy, O. Ushakov, O. Koval, I. Kovalskyi, Y. Svyshchenko, O. Sychov, M. Stanislavchuk, O. Kraydashenko, A. Yagensky, S. Tykhonova, I. Fushtey, R. Belegai, G. Berko, L. Burdeuna, O. Chabanna, I. Daniuk, A. Ivanov, E. Kamenska, P. Kaplan, O. Khyzhnyak, S. Kizim, O. Matova, O. Medentseva, V. Mochonyi, M. Mospan, V. Nemtsova, T. Ovdiienko, O. Palamarchuk, M. Pavelko, R. Petrovskyy, D. Plevak, O. Proshak, S. Pyvovar, L. Rasputina, O. Romanenko, O. Romanova, A. Sapatyi, O. Shumakov, R. Stets, L. Todoriuk, V. Varenov, D. Fitzmaurice, N. Chauhan, D. Goodwin, P. Saunders, R. Evans, J. Leese, P.S. Jhittay, A. Ross, M.S. Kainth, G. Pickavance, J. McDonnell, A. Williams, T. Gooding, H. Wagner, S. Suryani, A. Singal, S. Sircar, R. Bilas, P. Hutchinson, A. Wakeman, M. Stokes, N. Paul, M. Aziz, C. Ramesh, P. Wilson, S. Franklin, S. Fairhead, J. Thompson, V. St Joseph, G. Taylor, D. Tragen, D. Seamark, C. Paul, M. Richardson, A. Jefferies, H. Sharp, H. Jones, C. Giles, M. Page, O. Oginni, J. Aldegather, S. Wetherwell, W. Lumb, P. Evans, F. Scouller, N. Macey, Y. Stipp, R. West, S. Thurston, P. Wadeson, J. Matthews, P. Pandya, A. Gallagher, T. Railton, B. Sinha, D. Russell, J.A. Davies, P. Ainsworth, C.P. Jones, P. Weeks, J. Eden, D. Kernick, W. Murdoch, L. Lumley, R.P. Patel, S.W. Wong, M. Saigol, K. Ladha, K. Douglas, D.F. Cumberlidge, C. Bradshaw, G. Van Zon, K.P. Jones, M.J. Thomas, E. Watson, B. Sarai, N. Ahmad, W. Willcock, J. Cairns, S. Sathananthan, N. de Kare-Silver, A. Gilliland, E. Strieder, A. Howitt, B. Vishwanathan, N. Bird, D. Gray, M. Clark, J. Bisatt, J. Litchfield, E. Fisher, T. Fooks, A.R. Kelsall, E. Alborough, J. Wakeling, M. Parfitt, K. Milne, S. Rogers, R. Priyadharshan, J.L. Oliver, E. Davies, S. Abushal, M. Jacobs, C. Hutton, N.I. Walls, R. Thompson, C. Chigbo, S.M.A. Zaidi, M. Howard, K.C. Butter, S. Barrow, H. Little, I.U. Haq, L. Gibbons, S. Glencross, A.J. McLeod, K. Poland, C. Mulholland, A. Warke, P. Conn, G. Burns, R.N. Smith, S. Lowe, R. Kamath, H.S. Dau, J. Webster, I. Hodgins, S. Vercoe, P.C. Roome, H. Pinnock, J.R.A. Patel, A. Ali, N. Hart, R. Davies, E. Stuart, C.A. Neden, M. Danielsen, R. Heath, P. Sharma, S. Galloway, C. Hawkins, R. Oliver, M. Aylward, S. Mannion, M. Braddick, D. Edwards, A.C. Rothwell, A. Sabir, F. Choudhary, S. Khalaque, A. Wilson, S. Peters, W. Coulson, N. Roberts, A. Heer, S. Coates, B. Ward, D. Jackson, S. Walton, D. Shepherd, M. Sterry, T. Wong, M. Boon, R. Bunney, R. Haria-Shah, R.T. Baron, S. Davies, T. Schatzberger, N. Hargreaves, T. Stephenson, H. Choi, R. Batson, L. Lucraft, T. Myhill, S. Estifano, D. Geatch, J. Wilkinson, R. Veale, K. Forshaw, T. Davies, K. Zaman, P. Vinson, C. Liley, M. Bandrapalli, P. McGinty, R. Wastling, P. McEleny, A. Beattie, P. Cooke, M. Wong, J. Gunasegaram, M. Pugsley, S. Ahmad, C. A'Court, J. Ayers, J. Bennett, S. Cartwright, S. Dobson, C. Dooldeniya, A. Flynn, R. Fox, J. Goram, A. Halpin, A. Hay, P. Jacobs, L. Jeffers, L. Lomax, I. Munro, R. Muvva, M. Nadaph, K. Powell, S. Randfield, D. Redpath, R. Reed, M. Rickenbach, G. Rogers, P.B. Saunders, C. Seamark, J. Shewring, P. Simmons, H. Simper, H. Stoddart, A. Sword, N. Thomas, A. Thomson, H. Gibbs, A. Blenkhorn, B. Singh, W. Van Gaal, W. Abhayaratna, R. Lehman, P. Roberts-Thomson, J. Kilian, D. Coulshed, A. Catanchin, D. Colquhoun, H. Kiat, D. Eccleston, J. French, L. Zimmett, B. Ayres, T. Phan, P. Blombery, D. Crimmins, D. O'Donnell, A. Choi, P. Astridge, M. Arstall, N. Jepson, M. Binnekamp, A. Lee, J. Rogers, G. Starmer, P. Carroll, J. Faunt, A. Aggarwala, L. Barry, C. Batta, R. Beveridge, A. Black, M. Bonner, J. Boys, E. Buckley, M. Campo, L. Carlton, A. Connelly, B. Conway, D. Cresp, H. Dimitri, S. Dixon, M. Dolman, M. Duroux, M. Eskandari, R. Eslick, A. Ferreira-Jardim, T. Fetahovic, D. Fitzpatrick, R. Geraghty, J. Gibbs, T. Grabek, M.H. Modi, K. Hayes, M.P. Hegde, L. Hesketh, B. Hoffmann, B. Jacobson, K. Johnson, C. Juergens, I. Kassam, V. Lawlor, M. Lehman, S. Lehman, D. Leung, S. Mackay, M. MacKenzie, C. McCarthy, C. McIntosh, L. McKeon, H. Morrison, C. Mussap, J.-D. Myers, V. Nagalingam, G. Oldfield, V. O'May, J. Palmer, L. Parsons, K. Patching, T. Patching, V. Paul, M. Plotz, S. Preston, H. Rashad, M. Ratcliffe, S. Raynes, J. Rose, L. Sanders, M. Seremetkoska, H. Setio, S. Shone, P. Shrestha, C. Singh, C. Singleton, N. Stoyanov, S. Sutcliffe, K. Swaraj, J. Tarrant, S. Thompson, I.M. Tsay, M. Vorster, A. Waldman, L. Wallis, E. Wilford, K. Wong, S.J. Connolly, A. Spyropoulos, J. Eikelboom, R. Luton, M. Gupta, A.S. Pandey, S. Cheung, R. Leader, P. Beaudry, F. Ayala-Paredes, J. Berlingieri, J. Heath, G. Poirier, M. Du Preez, R. Nadeau, G. Dresser, R. Dhillon, T. Hruczkowski, B. Schweitzer, B. Coutu, P. Angaran, P. MacDonald, S. Vizel, S. Fikry, R. Parkash, A. Lavoie, J. Cha, B. Ramjattan, J. Bonet, K. Ahmad, L. Aro, T. Aves, K. Beaudry, C. Bergeron, J. Bigcanoe, N. Bignell, L. Breakwell, E. Burke, L. Carroll, B. Clarke, T. Cleveland, S. Daheb, P. Dehghani, I. Denis, Z. Djaidani, P. Dorian, S. Douglass, J. Dunnigan, A. Ewert, D. Farquhar, A. Fearon, L. Ferleyko, D. Fournier, B. Fox, M.-C. Grenier, W. Gulliver, K. Haveman, C. Hines, K. Hines, A.M. Jackson, C. Jean, G. Jethoo, R. Kahlon, S. Kelly, R. Kim, V. Korley, J. Kornder, L. Kwan, J. Largy, C. Lewis, S. Lewis, I. Mangat, R. Moor, J. Navratil, I. Neas, J. Otis, R. Otis, M. Pandey, F. Petrie, A. Pinter, M. Raines, P. Roberts, M. Robinson, G. Sas, S. Schulman, L. Snell, S. Spearson, J. Stevenson, T. Trahey, S. Wong, D. Wright, H. Ragy, A. Abd El-Aziz, S.K. Abou Seif, M.G. El Din, S. El Etriby, A. Elbahry, A. El-Etreby, M. Elkhadem, A. Katta, T. Khairy, A. Mowafy, M. Nawar, A. Ohanissian, A. Reda, M. Reda, H. Salem, N. Sami, S. Samir, M. Setiha, M. Sobhy, A. Soliman, N. Taha, M. Tawfik, E. Zaatout, D. Kettles, J. Bayat, H. Siebert, A. Horak, Y. Kelfkens, R. Garda, T. Pillay, M. Guerra, L. van Zyl, H. Theron, A. Murray, R. Louw, D. Greyling, P. Mntla, V. Ueckermann, R. Loghdey, S. Ismail, F. Ahmed, J. Engelbrecht, A. Ramdass, S. Maharajh, W. Oosthuysen, G. Angel, C. Bester, M. Booysen, C. Boshoff, C. Cannon, S. Cassimjee, C. Chami, G. Conway, A. Davids, L. de Meyer, G. Du Plessis, T. Ellis, L. Henley, M. Karsten, E. Loyd, J. Marks, L. Mavhusa, M. Mostert, A. Page, L. Rikhotso, M. Salie, J. Sasto, F. Shaik, A. Skein, L. Smith, G. Tarr, T. Tau, F. van Zyl, W. Al Mahmeed, G. Yousef, A. Agrawal, M. Nathani, M. Ibrahim, E.M. Esheiba, R. Singh, A. Naguib, M. Abu-Mahfouz, M. Al Omairi, A. Al Naeemi, R. Maruthanayagam, N. Bazargani, A. Wassef, R. Gupta, M. Khan, B. Subbaraman, A. Abdul, A. Al Mulla, S. El Bardisy, P. Haridas, S. Jadhav, K. Magdaluyo, M. Makdad, I. Maqsood, R. Mohamed, N. Sharma, R. Sharma, M. Thanzeel, S.Z. Goldhaber, R. Canosa, P. Rama, E. Blumberg, J. Garcia, P. Mullen, V. Wilson, A. Quick, K. Ferrick, W.M. Kutayli, M. Cox, M. Franco, S. Falkowski, R. Mendelson, M. Williams, S. Miller, S. Beach, A. Alfieri, T. Gutowski, I. Haque, R. Reddy, W. Ahmed, P. Delafontaine, D. Diercks, D. Theodoro, K. Remmel, M. Alberts, R. Ison, H. Noveck, P. Duffy, S. Pitta, D. Nishijima, C. Treasure, N. Asafu-Adjaye, K. Ball, M. Bartlett, M. Bentley, S. Bowers, A. Brown, A. Browne, J. Cameron-Watts, M. Canova, D. Cassidy, K. Cervellione, S. Congal, J. DePauw, A. Dickerson, M. Eley, L. Evans, S. Felpel, K. Ferdinand, D. Fielder, P. Gentry, A. Haideri, F. Hakimi, T. Harbour, E. Hartranft, B. Hawkins, M. Headlee, L. Henson, C. Herrick, T. Hicks, S. Jasinski, A. Jones, L. Jones, P. Jones, S. Karl, M. Keeling, J. Kerr, P. Knowles, J. Langdon, M. Lay, J.A. Lee, T. Lincoln, E. Malone, A. Merliss, D. Merritt, J. Minardo, B. Mooso, C. Orosco, V. Palumbo, M. Parker, T. Parrott, S. Paserchia, G. Pearl, J. Peterson, N. Pickelsimer, T. Purcell, J. Raynor, S. Raziano, C. Richard, T. Richardson, C. Robertson, A. Sage, T. Sanghera, P. Shaw, J. Shoemaker, K. Smith, B. Stephanie, A. Thatcher, H. Theobald, N. Thompson, L. Treasure, T. Tripti, C. Verdi, and V. Worthy

Subjects
Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P

Published
2018
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8. MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence

Author

J. Bousquet, S. Arnavielhe, A. Bedbrook, M. Bewick, D. Laune, E. Mathieu-Dupas, R. Murray, G. L. Onorato, J. L. Pépin, R. Picard, F. Portejoie, E. Costa, J. Fonseca, O. Lourenço, M. Morais-Almeida, A. Todo-Bom, A. A. Cruz, J. da Silva, F. S. Serpa, M. Illario, E. Menditto, L. Cecchi, R. Monti, L. Napoli, M. T. Ventura, G. De Feo, D. Larenas-Linnemann, M. Fuentes Perez, Y. R. Huerta Villabolos, D. Rivero-Yeverino, E. Rodriguez-Zagal, F. Amat, I. Annesi-Maesano, I. Bosse, P. Demoly, P. Devillier, J. F. Fontaine, J. Just, T. P. Kuna, B. Samolinski, A. Valiulis, R. Emuzyte, V. Kvedariene, D. Ryan, A. Sheikh, P. Schmidt-Grendelmeier, L. Klimek, O. Pfaar, K. C. Bergmann, R. Mösges, T. Zuberbier, R. E. Roller-Wirnsberger, P. Tomazic, W. J. Fokkens, N. H. Chavannes, S. Reitsma, J. M. Anto, V. Cardona, T. Dedeu, J. Mullol, T. Haahtela, J. Salimäki, S. Toppila-Salmi, E. Valovirta, B. Gemicioğlu, A. Yorgancioglu, N. Papadopoulos, E. P. Prokopakis, S. Bosnic-Anticevich, R. O’Hehir, J. C. Ivancevich, H. Neffen, E. Zernotti, I. Kull, E. Melen, M. Wickman, C. Bachert, P. Hellings, S. Palkonen, C. Bindslev-Jensen, E. Eller, S. Waserman, M. Sova, G. De Vries, M. van Eerd, I. Agache, T. Casale, M. Dykewickz, R. N. Naclerio, Y. Okamoto, D. V. Wallace, and MASK study group

Subjects
App, ARIA, Asthma, Care pathways, MASK, mHealth, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract mHealth, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching the goals. Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the best evidence-based approach to care pathways suited to real-life using mobile technology in allergic rhinitis (AR) and asthma multimorbidity. Patients largely use over-the-counter medications dispensed in pharmacies. Shared decision making centered around the patient and based on self-management should be the norm. Mobile Airways Sentinel networK (MASK), the Phase 3 ARIA initiative, is based on the freely available MASK app (the Allergy Diary, Android and iOS platforms). MASK is available in 16 languages and deployed in 23 countries. The present paper provides an overview of the methods used in MASK and the key results obtained to date. These include a novel phenotypic characterization of the patients, confirmation of the impact of allergic rhinitis on work productivity and treatment patterns in real life. Most patients appear to self-medicate, are often non-adherent and do not follow guidelines. Moreover, the Allergy Diary is able to distinguish between AR medications. The potential usefulness of MASK will be further explored by POLLAR (Impact of Air Pollution on Asthma and Rhinitis), a new Horizon 2020 project using the Allergy Diary.

Published
2018
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9. Dark particle mass effects on neutron star properties from a short-range correlated hadronic model

Author

M Dutra, C H Lenzi, and O Lourenço

Subjects
Nuclear Theory (nucl-th), High Energy Astrophysical Phenomena (astro-ph.HE), High Energy Physics - Phenomenology, High Energy Physics - Phenomenology (hep-ph), Nuclear Theory, Space and Planetary Science, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

In this work we study a relativistic mean-field (RMF) hadronic model, with nucleonic short-range correlations (SRC) included, coupled to dark matter (DM) through the Higgs boson. We study different parametrizations of this model by running the dark particle Fermi momentum, and its mass in the range of $50$ GeV $\leqslant M_\chi\leqslant 500$ GeV, compatible with experimental spin-independent scattering cross-sections. By using this RMF-SRC-DM model, we calculate some neutron star quantities, namely, mass-radius profiles, dimensionless tidal deformabilities, and crustal properties. Our findings show that is possible to construct RMF-SRC-DM parametrizations in agreement with constraints provided by LIGO and Virgo collaboration (LVC) on the GW170817 event, and recent observational data from the NICER mission. Furthermore, we show that the increase of $M_\chi$ favors the model to attain data from LVC regarding the tidal deformabilities. Higher values of $M_\chi$ also induce a reduction of the neutron star crust (mass and thickness), and cause a decrease of the crustal fraction of the moment of inertia ($I_{\rm{\tiny crust}}/I$). Nevertheless, we show that some RMF-SRC-DM parametrizations still exhibit $I_{\rm{\tiny crust}}/I>7\%$, a condition that explains the glitch activity in rotation-powered pulsars such as the Vela one. Therefore, dark matter content can also be used for describing such a phenomenon., Comment: 10 pages, 8 figures. Published in Monthly Notices of the Royal Astronomical Society

Published
2022

10. N-doped sponge-like biochar: a promising CO2 sorbent for CO₂/CH₄ and CO2/N₂ gas separation

Author

Mirtha A. O. Lourenço, Tânia Frade, Marta Bordonhos, Micaela Castellino, Moisés Pinto, and Sergio Bocchini

Subjects
Biochar, Pyrolyzed chitosan, Gas adsorption-separation, CO2 capture
Abstract

Sponge-like biochar sorbents were prepared from the dissolution of chitosan followed by freeze-drying methodology and pyrolysis at three different temperatures (400, 600, and 800 °C) to produce sustainable N-enriched carbon materials with enhanced CO2 uptake from CO2/CH4 and CO2/N2 gas mixtures. The pyrolysis process was reproduced by operando TGA-IR to study the gas evolved from the pyrolysis process. It was found that the pyrolysis temperature highly influences the textural properties of the chitosan sponge-like biochar materials, impacting mainly the amount and type of the N-species on the sample but also at the microporosity. XPS revealed the transformation of the amino groups from chitosan into pyridinic-N, pyrrolic-N, graphitic center-N, and graphitic valley-N or pyridine-N oxide species during the pyrolysis process. Increasing the pyrolysis temperature enhanced the quantity of the latter two N-type species. All sponge-like biochars adsorbed higher amounts of CO2 compared with CH4 and N2 gases, with maximum CO2 uptake (∼1.6 mmol⋅g−1) at 100 kPa and 25 °C for the sample pyrolyzed at 600 °C (named CTO_P600). Biochar produced at 800 °C showed no longer adsorption capacity for CH4 and N2, having the highest selectivity value for CO2/N2 separation under continuous flux conditions among all prepared biochar sorbents. Isobaric CO2 adsorption measurements on the CTO_P600 sorbent revealed that physisorption phenomena predominantly governed the CO2 adsorption process, which was confirmed by its consistent adsorption capacity after 10 consecutive adsorption–desorption cycles. Moreover, the biochar exhibited tolerance to water vapor adsorption, indicating its suitability to work under moisture-rich conditions. published

Published
2023

13. Thin film and surface preparation chamber for the low energy muons spectrometer

Author

Hanna Teuschl, Angelo Di Bernardo, Leandro M. O. Lourenço, Thomas Prokscha, Ricardo B. L. Vieira, and Zaher Salman

Subjects
History, Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, ddc:530, Computer Science Applications, Education
Abstract

We have designed and constructed a thin film preparation chamber with base pressure of $, Comment: 8 pages, 7 figures, muSR2020 conference proceedings

Published
2023

15. Multiscale computational approaches toward the understanding of materials

Author

Marta Bordonhos, Tiago L. P. Galvão, José R. B. Gomes, José D. Gouveia, Miguel Jorge, Mirtha A. O. Lourenço, José M. Pereira, Germán Pérez‐Sánchez, Moisés L. Pinto, Carlos M. Silva, João Tedim, and Bruno Zêzere

Subjects
Statistics and Probability, Numerical Analysis, Multidisciplinary, Modeling and Simulation
Abstract

Herewith, an overview of the group's collaborative research efforts on the development and deployment of computational approaches to understand materials and tools at different length and time scales is presented. The techniques employed range from quantum mechanical approaches based on the density functional theory to classical atomistic and coarse-grained force field methods, targeting molecular systems composed of a few to several million atoms at different levels of detail. These new tools and molecular models are presented to the computational materials science community so they can be used in more realistic molecular modelling studies of the properties of materials and their dependence on subtle modifications of their structures. The review concludes by presenting a selection of recent computational case-studies oriented toward the understanding of the synthesis of materials, the interpretation of unexpected experimental results, the prediction of material properties, and the materials selection based on their characteristics for applications in areas such as gas adsorption/separation, corrosion protection, and catalysis. published

Published
2022

17. Anti-Viral Photodynamic Inactivation of T4-like Bacteriophage as a Mammalian Virus Model in Blood

Author

Patrícia Santos, Ana T. P. C. Gomes, Leandro M. O. Lourenço, Maria A. F. Faustino, Maria G. P. M. S. Neves, and Adelaide Almeida

Subjects
Photosensitizing Agents, Porphyrins, Organic Chemistry, General Medicine, Catalysis, Computer Science Applications, Inorganic Chemistry, Methylene Blue, Anti-Infective Agents, Photochemotherapy, Bacteriophages, Physical and Theoretical Chemistry, Molecular Biology, antimicrobial photodynamic therapy, viral inactivation, blood, plasma, photosensitizers, porphyrins, methylene blue, Spectroscopy
Abstract

The laboratorial available methods applied in plasma disinfection can induce damage in other blood components. Antimicrobial photodynamic therapy (aPDT) represents a promising approach and is approved for plasma and platelet disinfection using non-porphyrinic photosensitizers (PSs), such as methylene blue (MB). In this study, the photodynamic action of three cationic porphyrins (Tri-Py(+)-Me, Tetra-Py(+)-Me and Tetra-S-Py(+)-Me) towards viruses was evaluated under white light irradiation at an irradiance of 25 and 150 mW·cm−2, and the results were compared with the efficacy of the approved MB. None of the PSs caused hemolysis at the isotonic conditions, using a T4-like phage as a model of mammalian viruses. All porphyrins were more effective than MB in the photoinactivation of the T4-like phage in plasma. Moreover, the most efficient PS promoted a moderate inactivation rate of the T4-like phage in whole blood. Nevertheless, these porphyrins, such as MB, can be considered promising and safe PSs to photoinactivate viruses in blood plasma.

Published
2022

18. Dark matter effects on tidal deformabilities and moment of inertia in a hadronic model with short-range correlations

Author

O. Lourenço, C. H. Lenzi, T. Frederico, and M. Dutra

Subjects
Nuclear Theory (nucl-th), High Energy Astrophysical Phenomena (astro-ph.HE), Nuclear Theory, FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena
Abstract

In this work we study the outcomes related to dimensionless tidal deformability $(\Lambda)$ obtained through a relativistic mean-field (RMF) hadronic model including short-range correlations (SRC) and dark matter (DM) content [Phys. Rev. D 105, 023008 (2022)]. As a dark particle candidate, we use the lightest neutralino interacting with nucleons through the Higgs boson exchange. In particular, we test the model against the constraints regarding the observation of gravitational waves from the binary neutron star merger GW170817 event provided by LIGO and Virgo collaboration (LVC). We show that $\Lambda$ decreases as the dark particle Fermi momentum ($k_F^{DM}$) increases. This feature favors the RMF-SRC-DM model used here to satisfy the limits of $\Lambda_{1.4}=190^{+390}_{-120}$ ($\Lambda$ of a $1.4M_\odot$ neutron star), and $\tilde{\Lambda}=300^{+420}_{-230}$ given by the LVC. We also show that as $k_F^{DM}$ increases, $\Lambda_1$ and $\Lambda_2$, namely, tidal deformabilities of the binary system, are also moved to the direction of the GW170817 observational data. Finally, we verify that the inclusion of DM in the system does not destroy the \mbox{$I$-Love} relation (correlation between $\Lambda$ and dimensionless moment of inertia, $\bar{I}$). The observation data for $\bar{I}_\star\equiv\bar{I}(M_\star)=11.10^{+3.68}_{-2.28}$, with $M_\star=1.338M_\odot$, is attained by the RMF-SRC-DM model., Comment: 8 pages, 4 figures. Published in Phys. Rev. D

Published
2022

19. Graphene Quantum Dots and Phthalocyanines Turn-OFF-ON Photoluminescence Nanosensor for ds-DNA

Author

Ana M. Santiago, Carla I. M. Santos, Leandro M. O. Lourenço, Inês F. A. Mariz, João P. C. Tomé, and Ermelinda Maçôas

Subjects
General Chemical Engineering, sensor, graphene quantum dot, phthalocyanine, DNA, photoluminescence, General Materials Science
Abstract

Supramolecular hybrids of graphene quantum dots (GQDs) and phthalocyanine (Pc) dyes were studied as turn-OFF-ON photoluminescence nanosensors for detection of ds-DNA. Pcs with four (Pc4) and eight (Pc8) positive charges were selected to interact with negatively charged GQDs. The photoluminescence of the GQDs was quenched upon interaction with the Pcs, due to the formation of non-emissive complexes. In the presence of ds-DNA, the Pcs interacted preferentially with the negatively charged ds-DNA, lifting the quenching effect over the photoluminescence of the GQDs and restoring their emission intensity. The best performance as a sensor of ds-DNA was registered for the GQD-Pc8, with a limit of detection (LOD) in the picomolar range. The LOD for GQD-Pc8 was more than one order of magnitude lower and its sensitivity was about a factor of three higher than that of the analogue GQD-Pc4 nanosensor. The sensitivity and selectivity of this simple GQD-Pc8 nanosensor is comparable to those of the more sophisticated carbon-based nanosensors for DNA reported previously.

Published
2022
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20. The Surprisingly Positive Effect of Zinc-Phthalocyanines With High Photodynamic Therapy Efficacy of Melanoma Cancer

Author

Kelly A. D. F. Castro, Juliana A. Prandini, Juliana Cristina Biazzotto, João P. C. Tomé, Roberto S. da Silva, and Leandro M. O. Lourenço

Subjects
General Chemistry
Abstract

Phthalocyanine (Pc) dyes are photoactive molecules that can absorb and emit light in the visible spectrum, especially in the red region of the spectrum, with great potential for biological scopes. For this target, it is important to guarantee a high Pc solubility, and the use of suitable pyridinium units on their structure can be a good strategy to use effective photosensitizers (PSs) for photodynamic therapy (PDT) against cancer cells. Zn(II) phthalocyanines (ZnPcs) conjugated with thiopyridinium units (1–3) were evaluated as PS drugs against B16F10 melanoma cells, and their photophysical, photochemical, and in vitro photobiological properties were determined. The photodynamic efficiency of the tetra- and octa-cationic ZnPcs 1–3 was studied and compared at 1, 2, 5, 10, and 20 µM. The different number of charge units, and the presence/absence of a-F atoms on the Pc structure, contributes for their PDT efficacy. The 3-(4′,5′-dimethylthiazol-2′-yl)-2,5-diphenyl tetrazolium bromide (MTT) assays on B16F10 melanoma cells show a moderate to high capacity to be photoinactivated by ZnPcs 1–3 (ZnPc 1 > ZnPc 2 > ZnPc 3). The best PDT conditions were found at a Pc concentration of 20 μM, under red light (λ = 660 ± 20 nm) at an irradiance of 4.5 mW/cm2 for 667 s (light dose of 3 J/cm2). In these conditions, it is noteworthy that the cationic ZnPc 1 shows a promising photoinactivation ratio, reaching the detection limit of the MTT method. Moreover, these results are comparable to the better ones in the literature.

Published
2022
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21. Photocatalytic Synthesis of Nitrogen‐Containing Heterocycles

Author

Leandro M. O. Lourenço, Kelly A D F Castro, Roberto Santana da Silva, and João P. C. Tomé

Subjects
Chemistry, Photocatalysis, chemistry.chemical_element, Brønsted–Lowry acid–base theory, Photochemistry, Gliocladin C, Nitrogen
Published
2020

22. Photoinactivation of Escherichia coli with Water-Soluble Ammonium-Substituted Phthalocyanines

Author

Sara R.D. Gamelas, Ana C. Gomes, Maria A. F. Faustino, João P. C. Tomé, Leandro M. O. Lourenço, Adelaide Almeida, and Augusto C. Tomé

Subjects
Gram-negative bacteria, biology, Chemistry, Biochemistry (medical), Biomedical Engineering, chemistry.chemical_element, General Chemistry, Zinc, biology.organism_classification, medicine.disease_cause, Medicinal chemistry, Biomaterials, medicine, Escherichia coli
Abstract

Zinc(II) phthalocyanines (Pcs) peripherally decorated with 2,4,6-tris(dimethylaminomethyl)phenoxy groups (Pcs 1 and 3) and the corresponding quaternized derivatives (Pcs 2 and 4) were synthesized a...

Published
2020

23. Supramolecular graphene–phthalocyanine assemblies for technological breakthroughs

Author

Joana M.D. Calmeiro, João P. C. Tomé, and Leandro M. O. Lourenço

Subjects
Materials science, Graphene, Supramolecular chemistry, chemistry.chemical_element, Nanotechnology, General Chemistry, law.invention, chemistry.chemical_compound, chemistry, law, Materials Chemistry, Phthalocyanine, Surface modification, Carbon
Abstract

Since the discovery of the well-structured carbon material, graphene (G), a huge research effort has been made to use it in several technological applications, such as photonic and nanoelectronic materials, due to its electrical, mechanical and thermal properties. The supramolecular functionalization of graphene with other molecules, such as phthalocyanines (Pcs), results in nanohybrids with improved photophysical properties. This review intends to show the impact of the scientific investigation that has been done on G–Pc supramolecular assemblies, in an attempt to improve their electronic performance, introducing new opportunities to their application in nanotechnology.

Published
2020

24. Synthesis and characterization of novel 5-monocarbohydrate-10,20-bis-aryl-porphyrins

Author

João P. C. Tomé, José A. S. Cavaleiro, Flávio Figueira, Leandro M. O. Lourenço, and Maria G. P. M. S. Neves

Subjects
Acrylate, chemistry.chemical_compound, chemistry, Singlet oxygen, Aryl, Galactose, Polymer chemistry, General Chemistry
Abstract

The synthesis of derivatives bearing glucose or galactose units linked by an acrylate spacer to one free meso position of a bis-aryl-porphyrin macrocycle was developed and characterized by standard spectroscopic techniques. The new mono-substituted gluco- and galacto-porphyrin derivatives 5–8 present an alternative to the widespread tetra-aryl porphyrin functionalization. Singlet oxygen studies showed a comparable singlet oxygen production with TPP. Furthermore, the less bulky architectures here synthesized present an opportunity to enhance the PDT and PDI capabilities of glycoporphyrins with a simple synthetic modification at one of the meso positions.

Published
2020

25. Photoinactivation of

Author

Sara R D, Gamelas, Ana T P C, Gomes, Maria Amparo F, Faustino, Augusto C, Tomé, João P C, Tomé, Adelaide, Almeida, and Leandro M O, Lourenço

Abstract

Zinc(II) phthalocyanines (Pcs) peripherally decorated with 2,4,6-tris(dimethylaminomethyl)phenoxy groups (Pcs

Published
2022

26. Unique multiphthalocyanine coordination systems: vibrationally hot excited states and charge transfer states that power high energy triplet charge separated states

Author

Jan Joseph, Leandro M. O. Lourenço, João P. C. Tomé, Tomás Torres, and Dirk M. Guldi

Subjects
General Materials Science
Abstract

Controlling the molecular architecture of well-organized organic building blocks and linking their functionalities with the impact of solar-light converting systems constitutes a grand challenge in materials science. Strong absorption cross-sections across the visible range of the solar spectrum as well as a finely balanced energy- and redox-gradient are all important features that pave the way for either funneling excited state energy or transducing charges. In light of this, we used thiopyridyl-phthalocyanines (PcSPy) and ruthenium (

Published
2022

27. Photoinactivation of Planktonic and Biofilm Forms of Escherichia coli through the Action of Cationic Zinc(II) Phthalocyanines

Author

Catarina I. V. Ramos, Maria G. P. M. S. Neves, Maria A. F. Faustino, João P. C. Tomé, Ângela Cunha, Leandro M. O. Lourenço, Maria C. Gomes, Deisy M. G. C. Rocha, Filipe A. Almeida Paz, and Adelaide Almeida

Subjects
chemistry.chemical_classification, Reactive oxygen species, Chemistry, Singlet oxygen, Organic Chemistry, Cationic polymerization, Biofilm, chemistry.chemical_element, Zinc, medicine.disease_cause, Analytical Chemistry, chemistry.chemical_compound, Biochemistry, medicine, Physical and Theoretical Chemistry, Escherichia coli
Published
2019

29. Biochar waste-based ZnO materials as highly efficient photocatalysts for water treatment

Author

Nuno P.F. Goncalves, Mirtha A. O. Lourenço, Simone R. Baleuri, Stefano Bianco, Pravin Jagdale, and Paola Calza

Subjects
History, Polymers and Plastics, Process Chemistry and Technology, Advanced oxidation processes, Pollution, Industrial and Manufacturing Engineering, Contaminants of emerging concern, Biochar, Zinc oxide, Chemical Engineering (miscellaneous), Business and International Management, Photocatalysis, Waste Management and Disposal
Published
2022

30. Influence of the meso-substituents of zinc porphyrins in dye-sensitized solar cell efficiency with improved performance under short periods of white light illumination

Author

Gabriel Gira, Ana Lucia Pinto, Joana M.D. Calmeiro, Francisco M. Ferraz, Leandro M. O. Lourenço, Cláudia C. L. Pereira, Sara Fernandes, and João P. C. Tomé

Subjects
Dye sensitized solar cells (DSSCs), Materials science, General Chemical Engineering, chemistry.chemical_element, 02 engineering and technology, Zinc, 010402 general chemistry, Photochemistry, 01 natural sciences, White light, Photoconversion efficiency, TiO2, Dyes, Process Chemistry and Technology, Photovoltaic system, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Ruthenium, Improved performance, Light intensity, Dye-sensitized solar cell, chemistry, Metalloporphyrin, Carboxylic acid anchoring group, 0210 nano-technology, Solar energy conversion efficiency, Macrocycles
Abstract

The sensitization activity of four zinc metalloporphyrin dyes: meso-tetrakis(4-pyridyl)porphyrinato Zn(II) (a), meso-triphenyl-(4-carboxyphenyl)porphyrinato Zn(II) (b), meso-tetrakis(4-carboxyphenyl)porphyrinato Zn(II) (c) and meso-tripyridyl(4-carboxyphenyl)porphyrinato Zn(II) (d) is reported here, in terms of current-potential curve, open-circuit potential, fill factor, and overall solar energy conversion efficiency which have been evaluated under 100 mW/cm2 light intensity and their performances compared to the benchmark N719 (di-tetrabutylammonium cis-bis(isothiocyanato)bis(2,2′-bipyridyl-4,4′-dicarboxylato) ruthenium(II)). This work focus the structural aspects of dyes with anchoring groups using TiO2-based Dye Sensitized Solar Cells (DSSCs), which includes pyridyl and carboxyphenyl acid groups and argue how the combination of both anchoring groups, in the same structure, may allow relevant optimization of DSSCs performance in the near future. Also, a noticeable improvement in the photovoltaic performance of all dyes, reaching a maximum increase from 25% to 69% in the overall DSSC efficiency under short periods of white light illumination is discussed.

Published
2020

31. Unsymmetrical cationic porphyrin-cyclodextrin bioconjugates for photoinactivation of Escherichia coli

Author

Sara R.D. Gamelas, Maria A. F. Faustino, Leandro M. O. Lourenço, Cláudia Ribeiro, João P. C. Tomé, Ana T. P. C. Gomes, and Adelaide Almeida

Subjects
Gram-negative bacteria, Porphyrins, Light, 030303 biophysics, Biophysics, Dermatology, Conjugated system, medicine.disease_cause, 030207 dermatology & venereal diseases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Escherichia coli, Pharmacology (medical), Photosensitizer, chemistry.chemical_classification, 0303 health sciences, Reactive oxygen species, Cyclodextrins, Photosensitizing Agents, Cyclodextrin, biology, Cationic polymerization, biology.organism_classification, Combinatorial chemistry, Porphyrin, Oncology, chemistry, Photochemotherapy
Abstract

Photodynamic inactivation (PDI) of microorganisms has been used for the treatment of bacterial infection. PDI is based on the combination of three non-toxic elements: a photosensitizer (PS), light and molecular oxygen, which lead to the formation of reactive oxygen species (ROS) that cause lethal oxidative damage into the target pathogenic bacteria. For that, clinical approved tetrapyrrolic macrocycles, with particular emphasis on photoactive porphyrin (Por) dyes, have been used as PS in PDI for different biomedical applications. Two novel unsymmetrical free-base thiopyridyl Pors conjugated with α- or γ-CD units (Pors 2 and 3) were prepared and the corresponding cationic ones (Pors 2a and 3a) were assessed as water-soluble photosensitizer (PS) agents by photophysical, photochemical and E. coli photobiological studies. The presence of the CD unit and the positive charges on the Por periphery (2a and 3a) enhance their solubility in aqueous media. The photoactivity of the two cationic Pors 2a and 3a ensures their potential as PDI drugs against Gram-negative bacteria model, a bioluminescent E. coli, which the best PDI efficiency was determined for Por 3a that achieved the highest bacterial reduction of 4.0 log10 (ANOVA, p < 0.0001), reaching the detection limit of the method after 15 min.

Published
2020

32. Study protocol to investigate biomolecular muscle profile as predictors of long-term urinary incontinence in women with gestational diabetes mellitus

Author

Marilza V. C. Rudge, Fátima P. Souza, Joelcio F. Abbade, Raghavendra L. S. Hallur, João Paulo C. Marcondes, Fernanda Piculo, Gabriela Marini, Giovana Vesentini, Lehana Thabane, Steven S. Witkin, Iracema M. P. Calderon, Angélica M. P. Barbosa, The Diamater Study Group, M. V. Rudge, A. M. P. Barbosa, I. M. P. Calderon, F. P. Souza, J. F. Abbade, L. S. R. Hallur, F. Piculo, G. Marini, G. Vesentini, L. Thabane, M. S. Palma, C. F. O. Graeff, R. K. Arni, R. D. Herculano, D. F. Salvadori, S. Mateus, M. Dal Pai Silva, C. G. Magalhães, R. A. Costa, S. A. M. Lima, S. L. Felisbino, W. Barbosa, A. Atallah, M. J. B. Girão, Z. Di Bella, S. M. Uchoa, S. Payão, A. Hijas, B. Berghman, R. De Bie, L. Sobrevia, B. Junginger, F. C. B. Alves, P. S. Rossignoli, C. B. Prudencio, M. I. G. Orlandi, M. I. Gonçalves, S. K. Nunes, B. B. Catinelli, S. Quiroz, B. V. Sarmento, F. A. Pinheiro, C. I. Sartorão, R. R. Lucas, D. R. A. Reyes, S. B. C. V. Quiroz, E. M. A. Enriquez, R. G. Oliveira, J. F. Floriano, J. P. C. Marcondes, S. Barneze, T. D. Dangió, T. Pascon, P. Rossignoli, J. V. Freitas, L. Takano, F. Reis, T. D. Caldeirão, J. N. Fernandes, A. M. Carr, M. V. C. Gaitero, J. E. Corrente, H. R. C. Nunes, A. F. Candido, S. M. B. Costa, J. V. F. Melo, F. V. D. S. Reis, G. A. Garcia, G. B. Rabadan, H. C. M. Bassin, K. S. Suyama, L. N. Damasceno, M. L. S. Takemoto, M. D. Menezes, D. G. Bussaneli, V. K. C. Nogueira, P. R. Lima, I. O. Lourenço, J. Marostica de Sá, R. A. Megid, I. P. Caruso, L. T. Rasmussen, G. M. Prata, M. A. Arantes, G. A. R. Ferraz, L. P. Camargo, M. R. Kron, Universidade Estadual Paulista (Unesp), FIB, Universidade Do Sagrado Coração (USC), McMaster University, St Joseph's Healthcare-Hamilton, Weill Cornell Medicine, and Universidade de São Paulo (USP)

Subjects
Proteomics, endocrine system diseases, Rectus Abdominis, Urinary incontinence, Gestational diabetes mellitus, Cohort Studies, Study Protocol, 0302 clinical medicine, Pregnancy, 030212 general & internal medicine, Palpation, 030219 obstetrics & reproductive medicine, Pelvic floor, Obstetrics, Postpartum Period, Obstetrics and Gynecology, Gestational Weight Gain, Pelvic floor muscles, Gestational diabetes, medicine.anatomical_structure, Vagina, Female, Collagen, medicine.symptom, Brazil, Maternal Age, Muscle Contraction, Hyperglycemic myopathy, Cohort study, Adult, medicine.medical_specialty, Gestational Age, lcsh:Gynecology and obstetrics, Rectus abdominis muscles, 03 medical and health sciences, Muscular Diseases, Diabetes mellitus, medicine, Humans, Muscle Strength, Myopathy, lcsh:RG1-991, Cesarean Section, Electromyography, business.industry, Pelvic Floor, medicine.disease, Diabetes, Gestational, business, Body mass index, Transmission electron microscopy
Abstract

Made available in DSpace on 2020-12-12T01:58:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-02-19 Background: Pelvic floor muscles (PFM) and rectus abdominis muscles (RAM) of pregnant diabetic rats exhibit atrophy, co-localization of fast and slow fibers and an increased collagen type I/III ratio. However, the role of similar PFM or RAM hyperglycemic-related myopathy in women with gestational diabetes mellitus (GDM) remains poorly investigated. This study aims to assess the frequency of pelvic floor muscle disorders and pregnancy-specific urinary incontinence (PS-UI) 12 months after the Cesarean (C) section in women with GDM. Specifically, differences in PFM/RAM hyperglycemic myopathy will be evaluated. Methods: The Diamater is an ongoing cohort study of four groups of 59 pregnant women each from the Perinatal Diabetes Research Centre (PDRC), Botucatu Medical School (FMB)-UNESP (São Paulo State University), Brazil. Diagnosis of GDM and PS-UI will be made at 24-26 weeks, with a follow-up at 34-38 weeks of gestation. Inclusion in the study will occur at the time of C-section, and patients will be followed at 24-48 h, 6 weeks and 6 and 12 months postpartum. Study groups will be classified as (1) GDM plus PS-UI; (2) GDM without PS-UI; (3) Non-GDM plus PS-UI; and (4) Non-GDM without PS-UI. We will analyze relationships between GDM, PS-UI and hyperglycemic myopathy at 12 months after C-section. The mediator variables to be evaluated include digital palpation, vaginal squeeze pressure, 3D pelvic floor ultrasound, and 3D RAM ultrasound. RAM samples obtained during C-section will be analyzed for ex-vivo contractility, morphological, molecular and OMICS profiles to further characterize the hyperglycemic myopathy. Additional variables to be evaluated include maternal age, socioeconomic status, educational level, ethnicity, body mass index, weight gain during pregnancy, quality of glycemic control and insulin therapy. Discussion: To our knowledge, this will be the first study to provide data on the prevalence of PS-UI and RAM and PFM physical and biomolecular muscle profiles after C-section in mothers with GDM. The longitudinal design allows for the assessment of cause-effect relationships between GDM, PS-UI, and PFMs and RAMs myopathy. The findings may reveal previously undetermined consequences of GDM. Department of Gynecology and Obstetrics Botucatu Medical School (FMB) São Paulo State University (UNESP) Physics Department Institute of Biosciences Letters and Exact Sciences Multiuser Center for Biomolecular Innovation UNESP-São Paulo State University Physiotherapy Department Faculdades Integradas de Bauru FIB Universidade Do Sagrado Coração (USC), Jardim Brasil Department of Health Research Methods Evidence and Impact McMaster University Biostatistics Unit Father Sean o'Sullivan Research Centre St Joseph's Healthcare-Hamilton Department of Obstetrics and Gynecology Weill Cornell Medicine Institute of Tropical Medicine University of Sao Paulo Medical School School of Philosophy and Sciences Department of Physiotherapy and Occupational Therapy UNESP-São Paulo State University Department of Gynecology and Obstetrics Botucatu Medical School (FMB) São Paulo State University (UNESP) Physics Department Institute of Biosciences Letters and Exact Sciences Multiuser Center for Biomolecular Innovation UNESP-São Paulo State University School of Philosophy and Sciences Department of Physiotherapy and Occupational Therapy UNESP-São Paulo State University

Published
2020

33. Comparative photodynamic inactivation of bioluminescent E. coli by pyridinium and inverted pyridinium chlorins

Author

Leandro M. O. Lourenço, João P. C. Tomé, Catarina I. V. Ramos, Maria A. F. Faustino, Adelaide Almeida, Joana M.D. Calmeiro, and Cristina J. Dias

Subjects
Detection limit, Process Chemistry and Technology, General Chemical Engineering, Cationic polymerization, chemistry.chemical_element, Context (language use), 02 engineering and technology, Zinc, 010402 general chemistry, 021001 nanoscience & nanotechnology, medicine.disease_cause, Photochemistry, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, chemistry, medicine, Bioluminescence, Fluence rate, Pyridinium, 0210 nano-technology, Escherichia coli
Abstract

Photodynamic inactivation (PDI) is a therapeutic approach in study due to the ability to reduce or completely eliminate the bacterial strains without the development of resistance mechanisms. In this therapeutic methodology the cationic chlorins (Chls) with pyridinium or inverted pyridinium moieties are one of the photosensitizers exploited in our biological approaches. In this context, we synthesized and characterized new free-base and zinc(II) complexes of pyridinium or inverted pyridinium Chl derivatives (1b, 2, 2a and 2b, respectively) for the inactivation of Escherichia coli (E. coli). The PDI assay was performed with white light irradiation delivered at a fluence rate of 25 mW cm−2. The obtained results of this study demonstrate high PDI efficiency of the zinc(II) metallated Chl 1b, reaching the detection limit of the bioluminescent method (5.2 log reduction) in 45 min of irradiation.

Published
2020

34. Phthalocyanines for G-quadruplex aptamers binding

Author

Jéssica Lopes-Nunes, Jean-Louis Mergny, Maria G. P. M. S. Neves, Leandro M. O. Lourenço, Carla Cruz, Catarina I. V. Ramos, João P. C. Tomé, João A. Queiroz, Joana Figueiredo, Josué Carvalho, and Gilmar F. Salgado

Subjects
Indoles, Cell Survival, Aptamer, Sequence (biology), Antineoplastic Agents, Isoindoles, G-quadruplex, 01 natural sciences, Biochemistry, Nucleobase, Cell Line, chemistry.chemical_compound, Neoplasms, Drug Discovery, Organometallic Compounds, Humans, Viability assay, Cytotoxicity, Molecular Biology, Gel electrophoresis, 010405 organic chemistry, Organic Chemistry, Aptamers, Nucleotide, Combinatorial chemistry, 0104 chemical sciences, G-Quadruplexes, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, chemistry, Oligodeoxyribonucleotides, Zinc Compounds, Phthalocyanine, HeLa Cells
Abstract

The G-quadruplex (G4)-forming sequence within the AS1411 derivatives with alternative nucleobases and backbones can improve the chemical and biological properties of AS1411. Zn(II) phthalocyanine (ZnPc) derivatives have potential as high-affinity G4 ligands because they have similar size and shape to the G-quartets. The interactions of four Zn(II) phthalocyanines with the G4 AS1411 aptamer and its derivatives were determined by biophysical techniques, molecular docking and gel electrophoresis. Cell viability assay was carried out to evaluate the antiproliferative effects of Zn(II) phthalocyanines and complexes. CD experiments showed structural changes after addition of ZnPc 4, consistent with multiple binding modes and conformations shown by NMR and gel electrophoresis. CD melting confirmed that ZnPc 2 and ZnPc 4, both containing eight positive charges, are able to stabilize the AT11 G4 structure (ΔTm > 30 °C and 18.5 °C, respectively). Molecular docking studies of ZnPc 3 and ZnPc 4 suggested a preferential binding to the 3′- and 5′-end, respectively, of the AT11 G4. ZnPc 3 and its AT11 and AT11-L0 complexes revealed pronounced cytotoxic effect against cervical cancer cells and no cytotoxicity to normal human cells. Zn(II) phthalocyanines provide the basis for the development of effective therapeutic agents as G4 ligands.

Published
2020

35. Microalgae culture collections, strain maintenance, and propagation

Author

Sergio O. Lourenço

Subjects
business.industry, Strain (biology), Chemical diversity, Identification (biology), Biology, business, Biological materials, Biotechnology
Abstract

Microalgae cultures are fundamental tools for the elucidation of innumerable ecological, ontogenetic, physiological, biochemical, and behavioral processes, among others, as well as for the generation of biomass for animal and human feeding and the production of substances of industrial importance. Once isolated from the natural environment, microalgae can be maintained indefinitely in culture. Whatever the use of microalgae cultures, their viability depends directly or indirectly on the existence of special laboratories for deposit, secure identification, propagation, and distribution to the public. Microalgae culture collections provide certified biological materials with quality, consistency, and safe information for users. These living libraries of biological resources enable immediate uses of microalgae strains, without the need for new isolations of nature and subsequent efforts of identification and adaptation to controlled growing conditions. In addition, microalgae culture collections provide an overview of the genetic, morphological, physiological, and chemical diversity known in nature. The maintenance of microalgae culture collections requires the organization of a technical team, a schedule for maintenance of stocks, and the periodic propagation of cultures. There are hundreds of collections of microalgae cultures around the world. Some of them count on thousands of strains, professionally organized services of diverse technicians and scientists, computerized collection, and international distribution of cultures of microalgae. On the other hand, some culture collections present only a few dozen strains, provide biological materials in a restricted way, and virtually all work is performed by a single person who accumulates all existing functions. Basic characteristics of culture collections of microalgae and their ways of functioning are presented in this chapter.

Published
2020

37. Overview of cationic phthalocyanines for effective photoinactivation of pathogenic microorganisms

Author

Leandro M. O. Lourenço and Cláudia Ribeiro

Subjects
Aqueous solution, Singlet oxygen, Organic Chemistry, Cationic polymerization, Thio, Quantum yield, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Phthalocyanine, Molecule, Pyridinium, Physical and Theoretical Chemistry, 0210 nano-technology
Abstract

Phthalocyanine (Pc) dyes are photoactive compounds that can absorb and emit light in a large range of the UV–vis spectrum, with recognized potential for medical applications. Considering the low solubility of Pc macrocycles in water, it is important to use cationic symptoms on their skeleton to improve their amphiphilicity for biomedical applications. The use of suitable pyridinium groups on Pc is a good strategy to solve this drawback and make them more eff ;ective to photoinactivate microorganisms via a photodynamic inactivation (PDI) approach. This review focuses the synthesis of quaternized Pc dyes, their photophysical and photochemical properties, and their antimicrobial photoinactivation efficiency. This innovative study compares, for the first time, different cationic moieties on Pc taking into account the efficiency of singlet oxygen (1O2), quantum yield (ΦΔ) generation, fluorescence quantum yield (ΦF), (photo)stability, light irradiation type (visible/white and/or red light), maximized overlapped absorption effect of Pc (S- and/or Q-band) vs light system irradiation type, and water solubility (n-octanol/water partition coefficient, Po/w), when these parameters are determined and provided in the multidisciplinary reports. This approach is also relevant to conjugate free-base (H2Pc) and metalated phthalocyanines (MPc, M = Zn2+, Mg2+, In3+, Ga3+, Ge3+, Si4+, etc.) with aromatic or aliphatic substituents linked by N, O or S atoms on the peripheral or axial positions of the Pc structures, such as e.g. (methoxy, oxy, or thio)pyridinium, ammonium, or benzimidazolium units, etc. Here, the influence of the structural peripheral (α- and/or β-position of Pc) or axial substituents type, number and positive charge position that can affect the PDI process will be analysed. These aspects are important to design versatile molecules that can interact with pathogenic microorganisms of variable size, subcellular architecture, biochemical composition, and susceptibility to externally added chemical agents. This review highlights the important developments of several modifications of cationic Pc dyes for the PDI of microorganisms, such as pathogenic bacteria, fungi, and virus.

Published
2021

38. Pyrazole-pyridinium porphyrins and chlorins as powerful photosensitizers for photoinactivation of planktonic and biofilm forms of E. coli

Author

Sara R.D. Gamelas, Isabela Santos, Cátia Vieira, Ana C. Gomes, Maria A. F. Faustino, Adelaide Almeida, Leandro M. O. Lourenço, and João P. C. Tomé

Subjects
biology, Chemistry, Process Chemistry and Technology, General Chemical Engineering, medicine.medical_treatment, Biofilm, Photodynamic therapy, biology.organism_classification, Antimicrobial, medicine.disease, medicine.disease_cause, chemistry.chemical_compound, medicine, Biophysics, Photosensitizer, Pyridinium, Cell damage, Escherichia coli, Bacteria
Abstract

In nature, microorganisms can form highly structured complexes designed as biofilms, that cause severe and chronic infectious in humans. The formation of biofilms provides microbes many advantages, resulting in a higher tolerance to the conventional treatments. Antimicrobial photodynamic therapy (aPDT) is an efficient therapeutic alternative to eradicate microbial cells, which combines a photosensitizer (PS), like porphyrins (Pors) or chlorins (Chls), oxygen and light to induce the formation of reactive oxygen species (ROS) that can lead to cell damage and even death. For this purpose, cationic Pors and Chls (1a and 2a, respectively) bearing 4-(1H-pyrazol-3-yl)pyridinium groups were synthesized and characterized, and their aPDT efficiency investigated against planktonic and biofilm forms of Escherichia coli, a Gram-negative bacterium. The obtained results demonstrate that Por 1a and Chl 2a exhibit high aPDT efficacy towards planktonic and biofilm forms of E. coli. For the planktonic cells, both PSs at 2.0 μM caused a bacterial photoinactivation till the detection limit of the method, after 30 min of red light irradiation at an irradiance of 14 mW cm−2 (25.2 J cm−2). However, under white light (25 mW cm−2), the aPDT efficiency of Por 1a was improved and completely inactivated E. coli after 10 min (15 J cm−2) of treatment. On the other hand, the photodynamic efficiency of Chl 2a at 2.0 μM has similar behaviour under the different light conditions. For the biofilm's assays, a complete photoinactivation was obtained by increasing the concentration of 1a and 2a to 10 and 5.0 μM, respectively, after 60 min under white light at an irradiance of 100 mW cm−2. The compound 1a exhibited a higher antimicrobial efficiency against the planktonic cells of E. coli, while 2a derivative was more efficient towards biofilms. This photodynamic efficiency can be related with the higher levels of 1O2 produced by 1a, as well as with the higher absorption in the red region exhibited by 2a, that might allow a better penetration in the biofilm structure. The potential of theses PSs is magnified with the low PS concentration and low light doses required, when compared with other cationic PSs, to achieve the total inactivation for both planktonic and biofilm forms of E. coli, which is a clear advantage for a clinical application.

Published
2021

39. An effective and potentially safe blood disinfection protocol using tetrapyrrolic photosensitizers

Author

Maria Af Faustino, Lúcia Marciel, Adelaide Almeida, João P. C. Tomé, Luís Teles, Mário Pacheco, Beatriz Moreira, Leandro M. O. Lourenço, and Maria G. P. M. S. Neves

Subjects
Staphylococcus aureus, Erythrocytes, Indoles, Porphyrins, Light, Blood Safety, medicine.medical_treatment, Photodynamic therapy, Isoindoles, Pharmacology, 010402 general chemistry, Photochemistry, 01 natural sciences, Plasma, chemistry.chemical_compound, Drug Discovery, Isotonic, Escherichia coli, medicine, Humans, Alternative methods, Photosensitizing Agents, biology, 010405 organic chemistry, Antimicrobial, biology.organism_classification, Porphyrin, 0104 chemical sciences, Disinfection, Blood, chemistry, Molecular Medicine, Bacteria
Abstract

Aim: Conventional disinfection techniques, considered safe for plasma, are usually associated with collateral damages on concentrated platelets and erythrocytes. Alternative methods are required and antimicrobial photodynamic therapy (aPDT) seems promising. In this study the effectiveness of two photosensitizers (PS), a porphyrin and a phthalocyanine, to disinfect blood products was evaluated. Results: The cationic porphyrin was more effective in the photoinactivation of bacteria. Also, no significant osmotic stress was found for samples treated with PS at 5.0 µM in isotonic conditions after antimicrobial photodynamic therapy. Conclusion: Effective reduction of Gram-positive bacteria at 5.0 µM of PS provided promising indications toward its safe use to disinfect blood samples. For Gram-negative bacteria, lower PS concentrations, between 5.0 and 10 µM, must be tested.

Published
2017

40. Biochemical and histopathological impacts of rutile and anatase (TiO

Author

Carla, Leite, Francesca, Coppola, Rui, Monteiro, Tania, Russo, Gianluca, Polese, Mirtha A O, Lourenço, Mariana R F, Silva, Paula, Ferreira, Amadeu M V M, Soares, Rosa, Freitas, and Eduarda, Pereira

Subjects
Mytilus, Titanium, Oxidative Stress, Animals, Water Pollutants, Chemical
Abstract

Titanium dioxide (TiO

Published
2019

41. Versatile thiopyridyl/pyridinone porphyrins combined with potassium iodide and thiopyridinium/methoxypyridinium porphyrins on E. coli photoinactivation

Author

Leandro M. O. Lourenço, João P. C. Tomé, Maria G. P. M. S. Neves, Maria A. F. Faustino, Joana M.D. Calmeiro, Ana T. P. C. Gomes, Adelaide Almeida, and Sara R.D. Gamelas

Subjects
chemistry.chemical_classification, Detection limit, Process Chemistry and Technology, General Chemical Engineering, Cationic polymerization, Salt (chemistry), chemistry.chemical_element, Context (language use), 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Iodine, medicine.disease_cause, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, medicine, Molecule, Pyridinium, 0210 nano-technology, Escherichia coli
Abstract

Porphyrins (Pors) are well-known photoactive molecules with recognized features to be explored as photosensitisers in the photodynamic inactivation (PDI) of microorganisms. The use of appropriate moieties like pyridinium groups is a remarkable strategy to add peripheral and internal positive charges in the Por structure making them more effective PSs against Gram-negative bacteria like Escherichia coli (E. coli). In this context, an easy synthetic access to obtain cationic Zn(II) porphyrins bearing thiopyridinium and inverted methoxypyridinium units (ZnPors 1c and 2c) was developed and their photo-physical and photo-chemical properties were evaluated. The photodynamic effectiveness of these complexes against a E. coli strain was also studied and compared with the efficacy of the corresponding free-bases (Pors 1b and 2b) and of the neutral precursors (Pors 1, 1a, 2, 2a), these last ones in the absence and in the presence of potassium iodide salt (KI). The obtained results demonstrate high PDI efficiency with the cationic free-base 1b and the ZnPor 2c; both derivatives were able to photoinactivate E. coli till the detection limit of the method at a concentration of 1.0 μM after 20 and 15 min of white light irradiation (25 mW cm−2), respectively. Interestingly, under the same experimental conditions (1.0 μM and white light), the neutral Pors (1, 1a, 2 and 2a) with addition of KI salt show a fast inactivation rate, reaching the detection limit of the method after 5 min of irradiation.

Published
2020

42. Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology

Author

Karin C. Lødrup Carlsen, L. Cecchi, F. Portejoie, T. Vontetsianos, Olivier Vandenplas, M. van Hague, D. Mora Bogado, M. Illario, Dana Wallace, L. Namazova-Baranova, E. Asayag, I. Ribeirinho, E. Costa, Shona Pedersen, Inger Kull, Davor Plavec, M. Morais-Almeida, Mickael Bewick, N.H. Chavannes, I. J. Ansotegui, G. De Carlo, K. S. Bennoor, Faradiba Sarquis Serpa, S. Arnavielle, F. Corti, Moises A. Calderon, Martín Bedolla-Barajas, Mette Sørensen, Isabella Annesi-Maesano, Elaine Colgan, Przemyslaw Kardas, M. van Eerd, Jorge Maspero, Valérie Siroux, Isabelle Momas, Ralph Mösges, Yves Dauvilliers, T. Keil, T. Bieber, Marit Westman, Rachel Nadif, O. Pfaar, A.C. Carvalho Coehlo, R. M. Cortés-Grimaldo, I. Skrindo, Piotr Kuna, Nicola Scichilone, Antonella Muraro, Kimihiro Okubo, Paulo Augusto Moreira Camargos, C. Cartier, Oliver Pfaar, K. Ohta, Barbara P. Yawn, Igor Kaidashev, Michel Thibaudon, X. Basagana, I. Kaidashev, Bilun Gemicioglu, S. Genova, Hae-Sim Park, J.J. Matta Campos, Simon Walker, Ulf Darsow, Fulvio Braido, J. Salimäki, T. Zuberbier, Raphaël Chiron, Mohammad Reza Masjedi, G.D. Marshall, Branislava Milenkovic, W. J. Fokkens, Eric D. Bateman, Robert M. Naclerio, Steve Montefort, M. de Fátima Emerson, T. Werfel, Cemal Cingi, A. Szylling, Martin Wagenmann, I. Baiardini, L. T. T. Le, N. Khaltaev, Ki-Suck Jung, Agnieszka Lipiec, Panayiotis K. Yiallouros, A Valero, R. Gerth van Wijk, L. Hernández, Marek L. Kowalski, C. Zubrinich, Sinthia Bosnic-Anticevich, Miguel A. Sierra, Erik Melén, T. Haahtela, Rute Almeida, Violeta Kvedariene, R. Pawankar, T.A. Popov, Flore Amat, Sanna Toppila-Salmi, M. Gotua, A. Sheikh, A. Bedbrook, Torsten Zuberbier, B. De Martino, Gérard Dray, Francesca Avolio, E. Mandajieva, B. Samolinski, Petr Panzner, P. Kuna, Philippe-Jean Bousquet, T. D. Nyembue, Luo Zhang, Leyla Namazova-Baranova, Ana Maria Carriazo, João Fonseca, E. Van Ganse, Roland Buhl, M. Bochenska Marciniak, Cristiana Stellato, J. da Silva, J. E. Gereda, Han-Jung Park, M.C. Costa-Dominguez, W. Carr, Dirceu Solé, S. Forti, Nanshan Zhong, Jordi Sunyer, Alain Didier, Y. Z. Chen, Thomas B. Casale, Jim Phillips, Isabelle Bosse, Manuel Teixeira Veríssimo, D. Y. Wang, U. Trama, Cristina Bárbara, David Somekh, T. Camuzat, R. N. Naclerio, Enrico Novellino, Leszek Klimek, M. Rodriguez Gonzalez, Holger J. Schünemann, Mario Barbagallo, D. Larenas-Linnemann, Mario Sánchez-Borges, Massimo Triggiani, Y. Okamoto, E. Mathieu-Dupas, N. Di Carluccio, S. Toppila-Salmi, Omer Kalayci, Rudolf Valenta, J. Coll, F. de Blay, Wienczyslawa Czarlewski, W. Pohl, Piotr Wroczyński, Kian Fan Chung, Nikolaos G. Papadopoulos, Pascal Demoly, Hubert Blain, M. Crescenzo, O. Kalayci, Leocadio Rodríguez-Mañas, G. Moda, L. Cox, Z. Gutter, A. Mair, Andrew Bush, Maria-Dolores Mogica-Martinez, Giorgio Walter Canonica, Antonio Valero, Daniel Laune, A. Zurkuhlen, Paul C. Potter, D. Wallace, Gabrielle L. Onorato, Mihaela Zidarn, E.P. Prokopakis, Anne Lise Courbis, Sergio Bonini, Ruta Dubakiene, A. Papi, Y. El-Gamal, Jacques Mercier, Wytske Fokkens, Rodolphe Bourret, S. Palkonen, A. Yorgancioglu, G. Vezzani, J. A. Rizzo, D. Plavec, D. Caillot, G. De Feo, E. Menditto, Caterina Bucca, A. C. Pozzi, Hironori Sagara, I. Grisle, I. Pin, Christopher E. Brightling, Ludger Klimek, F.F. Morato-Castro, Désirée Larenas-Linnemann, Alessandro Vatrella, A. A. Cruz, Guy Joos, E.D. Bateman, Erendira Rodriguez-Zagal, H. Douagui, T. To, Edgardo Jares, C. Bindslev-Jensen, G. Levato, J. O. B. Hourihane, R. Rajabian-Soderlund, C. Odzhakova, J. Bousquet, M. T. Ventura, Arzu Yorgancioglu, Osman M. Yusuf, H. J. Zar, Giovanni Rolla, Sebastian L. Johnston, M.S. Dykewicz, Esben Eller, A. Gamkrelidze, Filip Raciborski, Renzo Angles, Rafael Stelmach, M. Nogues, David Price, Mário Morais-Almeida, Tari Haahtela, Teresa To, D. Conforti, Stephen R. Durham, S. Gonzalez Diaz, V. Cardona, Werner Aberer, B. Milenkovic, Luigi Napoli, K. C. Bergmann, P W Hellings, M. Lessa, P. Panzner, Alfonso M. Cepeda Sarabia, M. Guidacci, A.L. Matos, Todor A. Popov, C. Suppli Ulrik, Diana Deleanu, N. de Paula Motta Rubini, Carsten Bindslev-Jensen, I. Majer, Ioana Agache, B. A. Barreto, R. Picard, Erkka Valovirta, A. Fink-Wagner, L. Colas, João O. Malva, Thomas Keil, M. T. Burguete Cabañas, Bolesław Samoliński, M.H. Garcia-Cruz, L.P. Boulet, K. Nekam, Edyta Krzych-Fałta, P. Devillier, J. Ferreira de Mello, Jussi Karjalainen, I. Bogus-Buczynska, Susan Waserman, Marcus Maurer, Tomas Chivato, Elena Bacci, M. Przemecka, Olga Lourenço, José Miguel Fuentes-Pérez, M. Zidarn, Talant Sooronbaev, J.M. Anto, W. Czarlewski, R. Murray, Luís Nogueira-Silva, G. Passalacqua, E. Chkhartishvili, Oscar Mayora, Victoria Cardona, M. Sondermann, Piotr Lacwik, S. Ouedraogo, I. Baroni, Artur Z. Białoszewski, G Scadding, J. Strozek, R. Emuzyte, Neven Miculinic, Ruby Pawankar, Ken Ohta, I. Agache, J.L. Gálvez-Romero, Nikos G. Papadopoulos, E. O. Meltzer, I. Annesi-Maesano, E. De Manuel Keenoy, Jorge A. Luna-Pech, Ana Margarida Pereira, Paul Potter, M. Ortega Cisneros, J. Li, K. F. Rabe, M. Rottem, Mikael Benson, Ali Fuat Kalyoncu, Dermot Ryan, Dieter Maier, C.Y. García-Cobas, S. Bialek, G. Du Toit, S. Shamai, S. Mavale-Manuel, Rojin Rajabian-Soderlund, Maddalena Illario, Philippe Devillier, F. Rodenas, Emmanuel P. Prokopakis, De Yun Wang, Niels H. Chavannes, E.H.D. Bel, Bianca Beghe, Sietze Reitsma, John Wright, O. Lourenço, L.T.T. Le, Josep M. Antó, T. Casale, Paul K. Keith, K. C. Lødrup Carlsen, P. Demoly, Mikael Kuitunen, Marc Humbert, A. M. Cepeda Sarabia, Ignacio J. Ansotegui, M.C. Rizzo, Davide Caimmi, Milan Sova, Nick A. Guldemond, P. Yakovliev, Judah A. Denburg, Jaime Correia de Sousa, Elisabete Melo-Gomes, Aziz Sheikh, I. Bosse, M. M. Ciaravolo, S. Di Capua Ercolano, Alpana Mair, P. Lieberman, Isabella Pali-Schöll, Leif Bjermer, G. De Vries, M. Roman Rodriguez, Johanna Salimäki, Carmen Panaitescu, F. Mihaltan, Giulia De Feo, F. E. R. Simons, A. Blua, B. Mahboub, D. Ryan, M. Bewick, Anabela Mota-Pinto, J.A. Fonseca, Neil Wilson, Marek Jutel, Dennis M. Williams, M. Akdis, Menachem Rottem, Marcello Persico, J. C. Ivancevich, Nelson Rosario, A. Farsi, Alvaro A. Cruz, Liguo Zhang, Anna Bedbrook, L. Bertorello, Magnus Wickman, Marilyn Urrutia-Pereira, O. Spranger, René Maximiliano Gómez, C. Bachert, Renaud Louis, Musa Khaitov, C. Stellato, Constantinos Pitsios, Roland Buonaiuto, A. Romano, Sîan A Williams, R. Puy, Daniela Rivero-Yeverino, Y. Mohammad, J. Farrell, Jan Brozek, Ricardo Pio Monti, E. Paulino, J. Correia de Sousa, Miguel Alejandro Medina-Ávalos, Jocelyne Just, Peter Valentin Tomazic, Jean-François Ferrero, Antoine Magnan, S. Waserman, J Rosado-Pinto, Maciek Kupczyk, C.S. Bosnic-Anticevich, T. Dedeu, Tommi Vasankari, R. Mösges, Robin O'Hehir, Ema Paulino, Peter Hellings, A. Neou, M. Wickman, D. Lauri, Jean Bousquet, A. Ciceran, Jacques Bouchard, Yehia El-Gamal, M.G. Dominguez-Silva, M.R. Alberti, Jean-Louis Pépin, Kimi Okubo, Juan Carlos Ivancevich, Patrik Eklund, Benoit Pugin, C. Dario, Mussa Khaitov, Luisa Brussino, A.G. Chuchalin, Elísio Costa, Susanna Palkonen, Lars Münter, Pedro Carreiro-Martins, R.E. Pulido Ross, Ettore Novellino, Kai-Håkon Carlsen, María Antonieta Guzmán, G.W. Canonica, Gabriel Onorato, Giuseppe De Carlo, R.E. Roller-Wirnsberger, Brian J. Lipworth, M. A. Guzman, J.N. Tebyriçá, Adnan Custovic, Yoshitaka Okamoto, Rimantas Stukas, P. Manning, J. Sastre-Dominguez, Caroline L.S. George, Robyn E O'Hehir, K. Maciej, Bassam Mahboub, J. F. Fontaine, Arũnas Valiulis, Xavier Rodó, D. Vicheva, G. Canfora, Vitalis Briedis, S. Rodrigues Valle, Mark S. Dykewicz, Joanne Rimmer, G. Castellano, B. Pigearias, A. L. Boner, Yunuen Rocío Huerta-Villalobos, Christine Rolland, H. Neffen, H. Arshad, Javier Gómez-Vera, P. Moura Santo, Frederic Viart, F. Blasi, J. Garcia-Aymerich, Lorenzo Cecchi, V. Niedeberger, Giorgio Ciprandi, F. Caballero-Fonseca, Jean-François Fontaine, J Mullol, Maurizio Romano, M. Viegi, Mario E. Zernotti, Arunas Valiulis, Anna Asarnoj, Antonio Nieto, J. Lavrut, D. Dokic, V. Kvedariene, Ewa Jassem, Cezmi A. Akdis, Ruth Murray, Claus Bachert, Peter Schmid-Grendelmeier, Emilie Burte, Joaquim Mullol, Guido Iaccarino, J. Kleine-Tebbe, P. V. Tomazic, E. Eller, Alessandro Fiocchi, H.J. Schunemann, M. Sorlini, C. Robalo-Cordeiro, Ana-Maria Todo-Bom, J. Brozek, Marco Nalin, Matteo Bonini, J. C. Sisul, S.E. Dahlen, F. Amat, Juan Carlos Sisul, Jawad Hajjam, Ana Todo-Bom, Enrica Menditto, Bousquet J., Hellings P.W., Agache I., Amat F., Annesi-Maesano I., Ansotegui I.J., Anto J.M., Bachert C., Bateman E.D., Bedbrook A., Bennoor K., Bewick M., Bindslev-Jensen C., Bosnic-Anticevich S., Bosse I., Brozek J., Brussino L., Canonica G.W., Cardona V., Casale T., Cepeda Sarabia A.M., Chavannes N.H., Cecchi L., Correia de Sousa J., Costa E., Cruz A.A., Czarlewski W., De Carlo G., De Feo G., Demoly P., Devillier P., Dykewicz M.S., El-Gamal Y., Eller E.E., Fonseca J.A., Fontaine J.-F., Fokkens W.J., Guzman M.-A., Haahtela T., Illario M., Ivancevich J.-C., Just J., Kaidashev I., Khaitov M., Kalayci O., Keil T., Klimek L., Kowalski M.L., Kuna P., Kvedariene V., Larenas-Linnemann D., Laune D., Le L.T.T., Carlsen K.L., Lourenco O., Mahboub B., Mair A., Menditto E., Milenkovic B., Morais-Almeida M., Mosges R., Mullol J., Murray R., Naclerio R., Namazova-Baranova L., Novellino E., O'Hehir R.E., Ohta K., Okamoto Y., Okubo K., Onorato G.L., Palkonen S., Panzner P., Papadopoulos N.G., Park H.-S., Paulino E., Pawankar R., Pfaar O., Plavec D., Popov T.A., Potter P., Prokopakis E.P., Rottem M., Ryan D., Salimaki J., Samolinski B., Sanchez-Borges M., Schunemann H.J., Sheikh A., Sisul J.-C., Rajabian-Soderlund R., Sooronbaev T., Stellato C., To T., Todo-Bom A.-M., Tomazic P.-V., Toppila-Salmi S., Valero A., Valiulis A., Valovirta E., Ventura M.-T., Wagenmann M., Wang D.Y., Wallace D., Waserman S., Wickman M., Yorgancioglu A., Zhang L., Zhong N., Zidarn M., Zuberbier T., Aberer W., Akdis C.A., Akdis M., Alberti M.R., Almeida R., Angles R., Arnavielle S., Asayag E., Asarnoj A., Arshad H., Avolio F., Bacci E., Baiardini I., Barbara C., Barbagallo M., Baroni I., Barreto B.A., Basagana X., Bedolla-Barajas M., Beghe B., Bel E.H., Bergmann K.C., Benson M., Bertorello L., Bialoszewski A.Z., Bieber T., Bialek S., Bjermer L., Blain H., Blasi F., Blua A., Bochenska Marciniak M., Bogus-Buczynska I., Boner A.L., Bonini M., Bonini S., Bouchard J., Boulet L.P., Bourret R., Braido F., Briedis V., Brightling C.E., Bucca C., Buhl R., Buonaiuto R., Panaitescu C., Burguete Cabanas M.T., Burte E., Bush A., Caballero-Fonseca F., Caillot D., Caimmi D., Calderon M.A., Camargos P.A.M., Camuzat T., Canfora G., Carreiro-Martins P., Carriazo A.M., Carr W., Cartier C., Castellano G., Chen Y., Chiron R., Chivato T., Chkhartishvili E., Chuchalin A.G., Chung K.F., Ciaravolo M.M., Ciceran A., Cingi C., Ciprandi G., Carvalho Coehlo A.C., Colas L., Colgan E., Coll J., Conforti D., Cortes-Grimaldo R.M., Corti F., Costa-Dominguez M.C., Courbis A.L., Cox L., Crescenzo M., Custovic A., Dahlen S.E., Dario C., da Silva J., Dauvilliers Y., Darsow U., De Blay F., Dedeu T., de Fatima Emerson M., De Vries G., De Martino B., de Paula Motta Rubini N., Deleanu D., Denburg J.A., Di Capua Ercolano S., Di Carluccio N., Didier A., Dokic D., Dominguez-Silva M.G., Douagui H., Dray G., Dubakiene R., Durham S.R., Du Toit G., Eklund P., Emuzyte R., Farrell J., Farsi A., Ferreira de Mello J., Ferrero J., Fink-Wagner A., Fiocchi A., Forti S., Fuentes-Perez J.M., Galvez-Romero J.L., Gamkrelidze A., Garcia-Aymerich J., Garcia-Cobas C.Y., Garcia-Cruz M.H., Gemicioglu B., Genova S., George C., Gereda J.E., Gerth van Wijk R., Gomez R.M., Gomez-Vera J., Gonzalez Diaz S., Gotua M., Grisle I., Guidacci M., Guldemond N.A., Gutter Z., Hajjam J., Hernandez L., Hourihane J.O., Huerta-Villalobos Y.R., Humbert M., Iaccarino G., Jares E.J., Jassem E., Johnston S.L., Joos G., Jung K.S., Jutel M., Kalyoncu A.F., Karjalainen J., Kardas P., Keith P.K., Khaltaev N., Kleine-Tebbe J., Kuitunen M., Kull I., Kupczyk M., Krzych-Falta E., Lacwik P., Lauri D., Lavrut J., Lessa M., Levato G., Li J., Lieberman P., Lipiec A., Lipworth B., Lodrup Carlsen K.C., Louis R., Luna-Pech J.A., Maciej K., Magnan A., Maier D., Majer I., Malva J., Mandajieva E., Manning P., De Manuel Keenoy E., Marshall G.D., Masjedi M.R., Maspero J.F., Mathieu-Dupas E., Matta Campos J.J., Matos A.L., Maurer M., Mavale-Manuel S., Mayora O., Medina-Avalos M.A., Melen E., Melo-Gomes E., Meltzer E.O., Mercier J., Miculinic N., Mihaltan F., Moda G., Mogica-Martinez M.D., Mohammad Y., Momas I., Montefort S., Monti R., Mora Bogado D., Morato-Castro F.F., Mota-Pinto A., Moura Santo P., Munter L., Muraro A., Nadif R., Nalin M., Napoli L., Neffen H., Niedeberger V., Nekam K., Neou A., Nieto A., Nogueira-Silva L., Nogues M., Nyembue T.D., Odzhakova C., Ortega Cisneros M., Ouedraogo S., Pali-Scholl I., Papi A., Passalacqua G., Pedersen S., Pepin J.L., Pereira A.M., Persico M., Phillips J., Picard R., Pigearias B., Pin I., Pitsios C., Pohl W., Portejoie F., Pozzi A.C., Price D., Puy R., Pugin B., Pulido Ross R.E., Przemecka M., Rabe K.F., Raciborski F., Reitsma S., Ribeirinho I., Rimmer J., Rivero-Yeverino D., Rizzo J.A., Rizzo M.C., Robalo-Cordeiro C., Rodenas F., Rodo X., Rodriguez Gonzalez M., Rodriguez-Manas L., Rolland C., Rodrigues Valle S., Roman Rodriguez M., Romano A., Rodriguez-Zagal E., Rolla G., Roller-Wirnsberger R.E., Romano M., Rosado-Pinto J., Rosario N., Sagara H., Sastre-Dominguez J., Scadding G.K., Scichilone N., Schmid-Grendelmeier P., Serpa F.S., Shamai S., Sierra M., Simons F.E.R., Siroux V., Skrindo I., Sole D., Somekh D., Sondermann M., Sova M., Sorensen M., Sorlini M., Spranger O., Stelmach R., Stukas R., Sunyer J., Strozek J., Szylling A., Tebyrica J.N., Thibaudon M., Trama U., Triggiani M., Suppli Ulrik C., Urrutia-Pereira M., Valenta R., van Eerd M., van Ganse E., van Hague M., Vandenplas O., Vezzani G., Vasankari T., Vatrella A., Verissimo M.T., Viart F., Viegi M., Vicheva D., Vontetsianos T., Walker S., Werfel T., Westman M., Williams D.M., Williams S., Wilson N., Wright J., Wroczynski P., Yakovliev P., Yawn B.P., Yiallouros P.K., Yusuf O.M., Zar H.J., Zernotti M.E., Zubrinich C., Zurkuhlen A., Bousquet, Jean, Hellings, Peter W., Agache, Ioana, Amat, Flore, Annesi-Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Clau, Bateman, Eric D., Bedbrook, Anna, Bennoor, Kazi, Bewick, Mickael, Bindslev-Jensen, Carsten, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Brozek, Jan, Brussino, Luisa, Canonica, Giorgio W., Cardona, Victoria, Casale, Thoma, Cepeda Sarabia, Alfonso M., Chavannes, Niels H., Cecchi, Lorenzo, Correia de Sousa, Jaime, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, De Carlo, Giuseppe, De Feo, Giulia, Demoly, Pascal, Devillier, Philippe, Dykewicz, Mark S., El-Gamal, Yehia, Eller, Esben E., Fonseca, Joao A., Fontaine, Jean-Françoi, Fokkens, Wytske J., Guzmán, Maria-Antonieta, Haahtela, Tari, Illario, Maddalena, Ivancevich, Juan-Carlo, Just, Jocelyne, Kaidashev, Igor, Khaitov, Musa, Kalayci, Omer, Keil, Thoma, Klimek, Ludger, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Desiree, Laune, Daniel, Le, Lan T. T., Carlsen, Karin Lodrup, Lourenço, Olga, Mahboub, Bassam, Mair, Alpana, Menditto, Enrica, Milenkovic, Branislava, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Murray, Ruth, Naclerio, Robert, Namazova-Baranova, Leyla, Novellino, Ettore, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Onorato, Gabrielle L., Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikos G., Park, Hae-Sim, Paulino, Ema, Pawankar, Ruby, Pfaar, Oliver, Plavec, Davor, Popov, Ted A., Potter, Paul, Prokopakis, Emmanuel P., Rottem, Menachem, Ryan, Dermot, Salimäki, Johanna, Samolinski, Boleslaw, Sanchez-Borges, Mario, Schunemann, Holger J., Sheikh, Aziz, Sisul, Juan-Carlo, Rajabian-Söderlund, Rojin, Sooronbaev, Talant, Stellato, Cristiana, To, Teresa, Todo-Bom, Ana-Maria, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Aruna, Valovirta, Erkka, Ventura, Maria-Teresa, Wagenmann, Martin, Wang, De Yun, Wallace, Dana, Waserman, Susan, Wickman, Magnu, Yorgancioglu, Arzu, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Zuberbier, Torsten, Bousquet, J., Hellings, P. W., Aberer, W., Agache, I., Akdis, C. A., Akdis, M., Alberti, M. R., Almeida, R., Amat, F., Angles, R., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Bachert, C., Baiardini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B. A., Basagana, X., Bateman, E. D., Bedolla-Barajas, M., Bedbrook, A., Bewick, M., Beghé, B., Bel, E. H., Bergmann, K. C., Bennoor, K. S., Benson, M., Bertorello, L., Białoszewski, A. Z., Bieber, T., Bialek, S., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Blua, A., Bochenska Marciniak, M., Bogus-Buczynska, I., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevich, C. S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, P. J., Braido, F., Briedis, V., Brightling, C. E., Brozek, J., Bucca, C., Buhl, R., Buonaiuto, R., Panaitescu, C., Burguete Cabañas, M. T., Burte, E., Bush, A., Caballero-Fonseca, F., Caillot, D., Caimmi, D., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Canfora, G., Canonica, G. W., Cardona, V., Carlsen, K. H., Carreiro-Martins, P., Carriazo, A. M., Carr, W., Cartier, C., Casale, T., Castellano, G., Cecchi, L., Cepeda Sarabia, A. M., Chavannes, N. H., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciaravolo, M. M., Ciceran, A., Cingi, C., Ciprandi, G., Carvalho Coehlo, A. C., Colas, L., Colgan, E., Coll, J., Conforti, D., Correia de Sousa, J., Cortés-Grimaldo, R. M., Corti, F., Costa, E., Costa-Dominguez, M. C., Courbis, A. L., Cox, L., Crescenzo, M., Cruz, A. A., Custovic, A., Czarlewski, W., Dahlen, S. E., Dario, C., da Silva, J., Dauvilliers, Y., Darsow, U., De Blay, F., De Carlo, G., Dedeu, T., de Fátima Emerson, M., De Feo, G., De Vries, G., De Martino, B., de Paula Motta Rubini, N., Deleanu, D., Demoly, P., Denburg, J. A., Devillier, P., Di Capua Ercolano, S., Di Carluccio, N., Didier, A., Dokic, D., Dominguez-Silva, M. G., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Du Toit, G., Dykewicz, M. S., El-Gamal, Y., Eklund, P., Eller, E., Emuzyte, R., Farrell, J., Farsi, A., Ferreira de Mello, J., Ferrero, J., Fink-Wagner, A., Fiocchi, A., Fokkens, W. J., Fonseca, J. A., Fontaine, J. F., Forti, S., Fuentes-Perez, J. M., Gálvez-Romero, J. L., Gamkrelidze, A., Garcia-Aymerich, J., García-Cobas, C. Y., Garcia-Cruz, M. H., Gemicioğlu, B., Genova, S., George, C., Gereda, J. E., Gerth van Wijk, R., Gomez, R. M., Gómez-Vera, J., González Diaz, S., Gotua, M., Grisle, I., Guidacci, M., Guldemond, N. A., Gutter, Z., Guzmán, M. A., Haahtela, T., Hajjam, J., Hernández, L., Hourihane, J. O. 'B., Huerta-Villalobos, Y. R., Humbert, M., Iaccarino, G., Illario, M., Ivancevich, J. C., Jares, E. J., Jassem, E., Johnston, S. L., Joos, G., Jung, K. S., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Karjalainen, J., Kardas, P., Keil, T., Keith, P. K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., Kowalski, M. L., Kuitunen, M., Kull, I., Kuna, P., Kupczyk, M., Kvedariene, V., Krzych-Fałta, E., Lacwik, P., Larenas-Linnemann, D., Laune, D., Lauri, D., Lavrut, J., Le, L. T. T., Lessa, M., Levato, G., Li, J., Lieberman, P., Lipiec, A., Lipworth, B., Lodrup Carlsen, K. C., Louis, R., Lourenço, O., Luna-Pech, J. A., Maciej, K., Magnan, A., Mahboub, B., Maier, D., Mair, A., Majer, I., Malva, J., Mandajieva, E., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Maspero, J. F., Mathieu-Dupas, E., Matta Campos, J. J., Matos, A. L., Maurer, M., Mavale-Manuel, S., Mayora, O., Medina-Avalos, M. A., Melén, E., Melo-Gomes, E., Meltzer, E. O., Menditto, E., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M. D., Mohammad, Y., Momas, I., Montefort, S., Monti, R., Mora Bogado, D., Morais-Almeida, M., Morato-Castro, F. F., Mösges, R., Mota-Pinto, A., Moura Santo, P., Mullol, J., Münter, L., Muraro, A., Murray, R., Naclerio, R., Nadif, R., Nalin, M., Napoli, L., Namazova-Baranova, L., Neffen, H., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, T. D., O'Hehir, R. E., Odzhakova, C., Ohta, K., Okamoto, Y., Okubo, K., Onorato, G. L., Ortega Cisneros, M., Ouedraogo, S., Pali-Schöll, I., Palkonen, S., Panzner, P., Papadopoulos, N. G., Park, H. S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pépin, J. L., Pereira, A. M., Persico, M., Pfaar, O., Phillips, J., Picard, R., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Pozzi, A. C., Price, D., Prokopakis, E. P., Puy, R., Pugin, B., Pulido Ross, R. E., Przemecka, M., Rabe, K. F., Raciborski, F., Rajabian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Rivero-Yeverino, D., Rizzo, J. A., Rizzo, M. C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Rodriguez Gonzalez, M., Rodriguez-Mañas, L., Rolland, C., Rodrigues Valle, S., Roman Rodriguez, M., Romano, A., Rodriguez-Zagal, E., Rolla, G., Roller-Wirnsberger, R. E., Romano, M., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Sagara, H., Salimäki, J., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schunemann, H. J., Scichilone, N., Schmid-Grendelmeier, P., Serpa, F. S., Shamai, S., Sheikh, A., Sierra, M., Simons, F. E. R., Siroux, V., Sisul, J. C., Skrindo, I., Solé, D., Somekh, D., Sondermann, M., Sooronbaev, T., Sova, M., Sorensen, M., Sorlini, M., Spranger, O., Stellato, C., Stelmach, R., Stukas, R., Sunyer, J., Strozek, J., Szylling, A., Tebyriçá, J. N., Thibaudon, M., To, T., Todo-Bom, A., Tomazic, P. V., Toppila-Salmi, S., Trama, U., Triggiani, M., Suppli Ulrik, C., Urrutia-Pereira, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., van Eerd, M., van Ganse, E., van Hague, M., Vandenplas, O., Ventura, M. T., Vezzani, G., Vasankari, T., Vatrella, A., Verissimo, M. T., Viart, F., Viegi, M., Vicheva, D., Vontetsianos, T., Wagenmann, M., Walker, S., Wallace, D., Wang, D. Y., Waserman, S., Werfel, T., Westman, M., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B. P., Yiallouros, P. K., Yorgancioglu, A., Yusuf, O. M., Zar, H. J., Zhang, L., Zhong, N., Zernotti, M. E., Zidarn, M., Zuberbier, T., Zubrinich, C., Zurkuhlen, A., CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Laboratory of clinical immunology, Department of Allergy and Clinical Immunology, Transylvania University of Brasov, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Epidémiologie, Systèmes d'Information, Modélisation, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Department of Allergy and Immunology, Hospital Quirónsalud Bizkaia [Bilbao], Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hacettepe University = Hacettepe Üniversitesi, Mechanobiology Institute [Singapore] (MBI), National University of Singapore (NUS), Department of Clinical Epidemiology and Biostatistics and Medicine, McMaster University [Hamilton, Ontario], Department of Dermatology [Graz, Austria], Medical University Graz, Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Department Engineering Quimica (ICEMS), Ghent University Hospital, Istituto Nazionale di Fisica Nucleare, sezione di Bari (INFN, sezione di Bari), Istituto Nazionale di Fisica Nucleare (INFN), IMIM-Hospital del Mar, Generalitat de Catalunya, University of Cape Town, Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton-School of Medicine, Centre de gérontologie, Department of Pathophysiology and Transplantation, Università degli Studi di Milano = University of Milan (UNIMI), Istituto di Geoscienze e Georisorse, Pavia, Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II = Università degli studi di Napoli Federico II, Woolcock Institute of Medical Research [Sydney], The University of Sydney, Université Laval [Québec] (ULaval), Departments of Clinical Epidemiology and Biostatistics and Medicine [Ontario], Service greffe de moelle osseuse, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Royal Brompton Hospital, Région Languedoc-Roussillon-Midi-Pyrénées, Vall d'Hebron University Hospital [Barcelona], University of South Florida [Tampa] (USF), Università degli Studi di Firenze = University of Florence (UniFI), University of Michigan, Department of Atmospheric, Centres de Ressources et de Compétences de la Mucoviscidose [Montpellier] (CRCM [Montpellier]), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve-Service des Maladies Respiratoires, Russian State Medical University, Universidade do Porto, Instituto de Biologia Molecular e Celular (IBMC), UCB Pharma, Colombes, Hôpital Gui de Chauliac [CHU Montpellier], CHU Strasbourg, European Federation of Allergy (EFA), Airways Diseases Patients' Associations, Università degli Studi di Salerno = University of Salerno (UNISA), Laboratoire de recherche sur les mécanismes moléculaires et pharmacologiques de l’obstruction bronchique (LOBIP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Linköping University (LIU), Department of Dermatology and Allergy Centre, Odense University Hospital, Vilnius University [Vilnius], Center of Research in Health Technologies and Information Systems (CINTESIS), Universidade do Porto = University of Porto, Institut d'Electronique du Solide et des Systèmes (InESS), Centre National de la Recherche Scientifique (CNRS), Son Pisa Primary Care Centre, IB-Salut Balearic Health Service, Center for Allergy and Immunology Research [Tbilisi], Department of Dermatology, Helsinki University Hospital-Skin and Allergy Hospital, Swedish Meteorological and Hydrological Institute (SMHI), CORYSS-TESS, Ukrainina Medical Stomatological Academy [Poltava, Ukraine], Institute of Social Medicine, Epidemiology and Health Economics-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Biologie des organismes marins et écosystèmes (BOME), Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), NRC Institute of immunology FMBA, Moscow Russian federation, Allergy and Asthma Center Westend, German Society for Otorhinolaryngology HNS, Rheinische Friedrich-Wilhelms-Universität Bonn, The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Medical University of Łódź (MUL), Hospital Medica Sur, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Applied Physical Chemistry Laboratory (APCLab), Institute of Geophysics and Planetary Physics [Los Angeles] (IGPP), University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), Équipe de Recherche en Textes, Informatique, Multilinguisme (ERTIM), Institut National des Langues et Civilisations Orientales (Inalco), Institute of Oceanology [China], University of Beira Interior [Portugal] (UBI), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Pulmonary and allergy unit, American University of Sharjah-Rashid Hospital-Dubai Health Authority (DHA), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Sysdiag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic (SysDiag ), BIO-RAD-Centre National de la Recherche Scientifique (CNRS), 'Federico II' University of Naples Medical School, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Pneumology Department, Marius Nasta Institute of Pneumology, Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw - Poland-Faculté de Pharmacie de Paris, Allergy and Clinical Immunology Department, Hospital CUF Descobertas, Universität zu Köln = University of Cologne, Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Section of Otolaryngology-Head & Neck Surgery (OHNS), University of Chicago, Department of Pharmacy Naples, Université de Naples, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital-Monash University Building, AMREP, Dept. of Electronic Engineering, Chubu University, Department of Otorhinolaryngology, Chiba University Hospital, Department of Allergology and Clinical Immunology, Charles University [Prague] (CU)-Medical Faculty in Pilsen, Department of Earth and Planetary Sciences [Cambridge, USA] (EPS), Harvard University, Allergy and Respiratory Diseases, Università degli studi di Genova = University of Genoa (UniGe), Department of Pediatrics, Nippon Medical School, Centre Hospitalier Universitaire [Grenoble] (CHU), Department of Otorhinolaryngology, Head and Neck Surgery [Mannheim, Germany], University Hospital Mannheim, Laboratoire de physique et chimie des nano-objets (LPCNO), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), CHU Grenoble, Children’s Hospital Srebrnjak [Zagreb, Croatia], Department of Physics [UMIST Manchester], University of Manchester Institute of Science and Technology (UMIST), Laboratori Nazionali del Sud (LNS), Getafe University Hospital, Madrid, Karl-Franzens-Universität Graz, Ecologie comportementale (EC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes (UR)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Allergy Asthma and Immunology [Haifa, Israel], Ha'Emek Medical Center, Afula-Rappaport Faculty of Medicine, University of Edinburgh, Medical University of Warsaw - Poland, Department of Allergy and Clinical Immunology [Caracas, Venezuela], Centro Médico Docente La Trinidad, Department of Computer Science [Haifa], University of Haifa [Haifa], Allergy and Respiratory Research Group, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), National Centre of Cardiology and Internal Medicine, Ministry of Health Kyrgyz Republic, Réseau National de Surveillance Aérobiologique (RNSA), Berkeley Seismological Laboratory, Division of Clinical Immunology and Allergy, University of Naples Federico II = Università degli studi di Napoli Federico II, CIRCE, Ctr Res Energy Resources & Consumpt, Zaragoza 50018, Spain, Vilnius University Clinic of Children's Diseases, Suomen Terveystalo Allergy Clinic, Health Service and Performance Research (HESPER), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre d'EPistémologie et d'ERgologie Comparatives (CEPERC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institute for Climate and Atmospheric Science [Leeds] (ICAS), School of Earth and Environment [Leeds] (SEE), University of Leeds-University of Leeds, Nova Southeastern University (NSU), Department of Otolaryngology, National University of Singapore (NUS)-Yong Loo Lin School of Medicine, Sachs' Children's Hospital, IAES, Department of Pulmonology, Manisa Celal Bayar University, Center for Evolutionary and Theoretical Immunology [Albuquerque, New Mexico] (CETI), The University of New Mexico [Albuquerque], National Key State Laboratory for ThermoStructural Composites (TSCM), Northwestern Polytechnical University [Xi'an] (NPU), Respiratory and Allergic Diseases, University Clinic of Respiratory and Allergic Diseases Golnik, University Hospital of Cologne [Cologne], Supported by the European Innovation Partnership on Active and Healthy Ageing and POLLAR (EIT Health, European Union)., European Project: 643803,H2020,H2020-HCO-2014,PROEIPAHA(2015), UCL - (MGD) Service de pneumologie, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidemiology of Allergic and Respiratory Diseases Department [Paris] (EPAR), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospital Quiròn Bizkaia Erandio, Université Pierre et Marie Curie - Paris 6 (UPMC), University of Milan, University of Naples Federico II-CNR, Rome, Italy and Department of Medicine, Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Hôpital Gui de Chauliac, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Università degli Studi di Salerno (UNISA), Institut de Physique du Globe de Paris (IPGP), Centre National de la Recherche Scientifique (CNRS)-Université de La Réunion (UR)-Université Paris Diderot - Paris 7 (UPD7)-IPG PARIS-Institut national des sciences de l'Univers (INSU - CNRS), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]-Epidemiology and Health Economics, Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN), University of California-University of California, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospital CUF-Descobertas, Universität zu Köln, Medical Faculty in Pilsen-Charles University in Prague - the First Faculty of Medicine, Harvard University [Cambridge], University of Genoa (UNIGE), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), University of Graz, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université Claude Bernard Lyon 1 (UCBL), Centro Medico-Docente La Trinidad, Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Università degli studi di Napoli Federico II, Center for Evolutionary and theoretical Immunology, Biology, National Institute for Health Research, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II, Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Karl-Franzens-Universität [Graz, Autriche], Department of Dermatology, Allergology and Venereology, Clinicum, University of Helsinki, Children's Hospital, Faculty of Law, HUS Children and Adolescents, HUS Inflammation Center, University Hospitals Leuven [Leuven], Universitat Pompeu Fabra [Barcelona]-Catalunya ministerio de salud, University of Zürich [Zürich] (UZH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), University of South Florida (USF), Università degli Studi di Firenze = University of Florence [Firenze], Laboratoire Magmas et Volcans (LMV), Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Universidade do Porto [Porto], Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin -Epidemiology and Health Economics, Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Sondra, CentraleSupélec, Université Paris-Saclay (COmUE) (SONDRA), ONERA-CentraleSupélec-Université Paris Saclay (COmUE), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), RNSA, Centre d'EPistémologie et d'ERgologie Comparatives - UMR 7304 (CEPERC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Ear, Nose and Throat, AII - Inflammatory diseases, Pulmonology, Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), National Institute for Nuclear Physics (INFN), Université Laval, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Università degli Studi di Firenze [Firenze], University of Salerno (UNISA), Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Sondra, CentraleSupélec, Université Paris-Saclay (SONDRA), ONERA-CentraleSupélec-Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), École normale supérieure - Paris (ENS Paris)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes 1 (UR1), Universidade do Minho, İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, uBibliorum, and Internal Medicine

Subjects
Allergy, Medicina Básica [Ciências Médicas], asthma -- guideline, Allergic asthma, DECISION-MAKING, Allergic Rhinitis and Its Impact on Asthma, GUIDELINES, Medical and Health Sciences, Medical Records, 0302 clinical medicine, Health care, Immunology and Allergy, 030212 general & internal medicine, asthma, Change management, rhinitis, Immunology, MASK-RHINITIS, ComputingMilieux_MISCELLANEOUS, Rinitis, mobilne aplikacije, upravljanje sprememb, Medical record, GLOBAL STRATEGY, WORK PRODUCTIVITY, Telemedicine, mobile applications, 3. Good health, Asma alérgica, rhiniti, 1107 Immunology, Ciências Médicas::Medicina Básica, klinične poti, allergic -- guideline, Life Sciences & Biomedicine, Human, PATIENT PARTICIPATION, Allergic Rhinitis, medicine.medical_specialty, animal structures, multimorbidity, EUROPEAN INNOVATION PARTNERSHIP, Change Management, [object Object], Settore MED/10 - Malattie Dell'Apparato Respiratorio, Asthma/diagnosis, CHRONIC DISEASES, MACVIA-ARIA, 03 medical and health sciences, medicine, multimorbidnost, QUALITY, Humans, critical pathways, astma -- smernica, Patient participation, Asma, udc:616.2, Asthma, Science & Technology, ARIA, business.industry, Multimorbidity, Rhinitis, Allergic, Settore MED/09 - MEDICINA INTERNA, change management, Mobile Airways Sentinel Network (MASK) Study Group, Guideline, ta3121, medicine.disease, Rinite alérgica, Rhinitis, Allergic/diagnosis, Integrated care, alergijski rinitis -- smernica, Allergic Rhinitis and Its Impact on Asthma, asthma, Change management, rhinitis, Immunology and Allergy, Immunology, 030228 respiratory system, Family medicine, 3121 General medicine, internal medicine and other clinical medicine, Medical Record, Clinical Medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Impact on Asthma
Abstract

Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional., EAACI -European Academy of Allergy and Clinical Immunology(undefined), info:eu-repo/semantics/acceptedVersion

Published
2018

43. Management and 1‐Year Outcomes of Patients With Newly Diagnosed Atrial Fibrillation and Chronic Kidney Disease: Results From the Prospective GARFIELD‐AF Registry

Author

Goto, Shinya, primary, Angchaisuksiri, Pantep, additional, Bassand, Jean‐Pierre, additional, Camm, A. John, additional, Dominguez, Helena, additional, Illingworth, Laura, additional, Gibbs, Harry, additional, Goldhaber, Samuel Z., additional, Goto, Shinichi, additional, Jing, Zhi‐Cheng, additional, Haas, Sylvia, additional, Kayani, Gloria, additional, Koretsune, Yukihiro, additional, Lim, Toon Wei, additional, Oh, Seil, additional, Sawhney, Jitendra P. S., additional, Turpie, Alexander G. G., additional, van Eickels, Martin, additional, Verheugt, Freek W. A., additional, Kakkar, Ajay K., additional, Fitzmaurice, David A., additional, Hacke, Werner, additional, Mantovani, Lorenzo G., additional, Misselwitz, Frank, additional, Pieper, Karen S., additional, Fox, Keith A. A., additional, Gersh, Bernard J., additional, Luciardi, Hector Lucas, additional, Brodmann, Marianne, additional, Cools, Frank, additional, Barretto, Antonio Carlos Pereira, additional, Connolly, Stuart J., additional, Spyropoulos, lex, additional, Eikelboom, John, additional, Corbalan, Ramon, additional, Hu, Dayi, additional, Jansky, Petr, additional, Nielsen, Jørn Dalsgaard, additional, Ragy, Hany, additional, Raatikainen, Pekka, additional, Le Heuzey, Jean‐Yves, additional, Darius, Harald, additional, Keltai, Matyas, additional, Kakkar, Sanjay, additional, Agnelli, Giancarlo, additional, Ambrosio, Giuseppe, additional, Sánchez Díaz, Carlos Jerjes, additional, Ten Cate, Hugo, additional, Atar, Dan, additional, Stepinska, Janina, additional, Panchenko, Elizaveta, additional, Jacobson, Barry, additional, Viñolas, Xavier, additional, Rosenqvist, Marten, additional, Steffel, Jan, additional, Oto, Ali, additional, Parkhomenko, Alex, additional, Mahmeed, Wael Al, additional, Fitzmaurice, David, additional, Chen, K. N., additional, Zhao, Y. S., additional, Zhang, H. Q., additional, Chen, J. Z., additional, Cao, S. P., additional, Wang, D. W., additional, Yang, Y. J., additional, Li, W. H., additional, Yin, Y. H., additional, Tao, G. Z., additional, Yang, P., additional, Chen, Y. M., additional, He, S. H., additional, Wang, Y. (Ying), additional, Wang, Y. (Yong), additional, Fu, G. S., additional, Li, X., additional, Wu, T. G., additional, Cheng, X. S., additional, Yan, X. W., additional, Zhao, R. P., additional, Chen, M. S., additional, Xiong, L. G., additional, Chen, P., additional, Jiao, Y., additional, Guo, Y., additional, Xue, L., additional, Wang, F. Z., additional, Li, H., additional, Yang, Z. M., additional, Bai, C. L., additional, Chen, J., additional, Chen, J. Y., additional, Chen, X., additional, Feng, S., additional, Fu, Q. H., additional, Gao, X. J., additional, Guo, W. N., additional, He, R. H., additional, He, X. A., additional, Hu, X. S., additional, Huang, X. F., additional, Li, B., additional, Li, J., additional, Li, L., additional, Li, Y. H., additional, Liu, T. T., additional, Liu, W. L., additional, Liu, Y. Y., additional, Lu, Z. C., additional, Luo, X. L., additional, Ma, T. Y., additional, Peng, J. Q., additional, Sheng, X., additional, Shi, X. J., additional, Sun, Y. H., additional, Tian, G., additional, Wang, K., additional, Wang, L., additional, Wu, R. N., additional, Xie, Q., additional, Xu, R. Y., additional, Yang, J. S., additional, Yang, L. L., additional, Yang, Q., additional, Ye, Y., additional, Yu, H. Y., additional, Yu, J. H., additional, Yu, T., additional, Zhai, H., additional, Zhan, Q., additional, Zhang, G. S., additional, Zhang, Q., additional, Zhang, R., additional, Zhang, Y., additional, Zheng, W. Y., additional, Zhou, B., additional, Zhou, Z. H., additional, Zhu, X. Y., additional, Oda, H. (Hiroshi), additional, Nakamura, (Tadashi), additional, Nakamura, T. (Tsugihiro), additional, Fujiura, Y. (Yoshihisa), additional, Saito, K. (Katsumi), additional, Saito, K. (Kazuyuki), additional, Fujiura, Y. (Yoshitake), additional, Nakamura, Y. (Yoichi), additional, Oda, H. (Hiroyuki), additional, Morii, S., additional, Shiga, Y. (Yuhei), additional, Nii, K., additional, Nakamura, Y. (Yuichiro), additional, Fujii, M., additional, Abe, M. (Masahiko), additional, Abe, M. (Masatake), additional, Abe, M. (Mitsunori), additional, Saito, T., additional, Mito, T., additional, Nagao, K., additional, Minami, J., additional, Mita, T., additional, Sakuma, I., additional, Taguchi, T., additional, Marusaki, S., additional, Doi, H., additional, Tanaka, M., additional, Fujito, T., additional, Matsuta, M., additional, Kusumoto, T., additional, Kakinoki, S., additional, Ashida, K., additional, Yoshizawa, N., additional, Agata, J., additional, Arasaki, O., additional, Manita, M., additional, Ikemura, M., additional, Fukuoka, S., additional, Murakami, H., additional, Matsukawa, S., additional, Hata, Y., additional, Taniguchi, T., additional, Ko, T., additional, Kubo, H., additional, Imamaki, M., additional, Akiyama, M., additional, Inagaki, M., additional, Odakura, H., additional, Ueda, T., additional, Katsube, Y., additional, Nakata, A., additional, Watanabe, H., additional, Techigawara, M., additional, Igarashi, M., additional, Taga, K., additional, Kimura, T., additional, Tomimoto, S., additional, Shibuya, M., additional, Nakano, M., additional, Ito, K., additional, Seo, T., additional, Hiramitsu, S., additional, Hosokawa, H., additional, Hoshiai, M., additional, Hibino, M., additional, Miyagawa, K., additional, Horie, H. (Hajime), additional, Sugishita, N., additional, Shiga, Y. (Yukio), additional, Soma, A., additional, Neya, K., additional, Yoshida, T. (Tetsuro), additional, Yoshida, T. (Tomoki), additional, Mizuguchi, M., additional, Ishiguro, M., additional, Minagawa, T., additional, Wada, M., additional, Mukawa, H., additional, Okuda, F., additional, Nagasaka, S., additional, Abe, Y., additional, Adachi, S. (Sen), additional, Adachi, S. (Susumu), additional, Adachi, T., additional, Akahane, K., additional, Amano, T., additional, Aoki, K., additional, Aoyama, T., additional, Arai, H., additional, Arima, S., additional, Arino, T., additional, Asano, H., additional, Asano, T., additional, Azuma, J., additional, Baba, T., additional, Betsuyaku, T., additional, Chibana, H., additional, Date, H., additional, Doiuchi, J., additional, Emura, Y., additional, Endo, M., additional, Fujii, Y., additional, Fujiki, R., additional, Fujisawa, A., additional, Fujisawa, Y., additional, Fukuda, T., additional, Fukui, T., additional, Furukawa, N., additional, Furukawa, T., additional, Furumoto, W., additional, Goto, T., additional, Hamaoka, M., additional, Hanazono, N., additional, Hasegawa, K., additional, Hatsuno, T., additional, Hayashi, Y., additional, Higuchi, K., additional, Hirasawa, K., additional, Hirayama, H., additional, Hirose, M., additional, Hirota, S., additional, Honda, M., additional, Horie, H. (Hideki), additional, Ido, T., additional, Iiji, O., additional, Ikeda, H., additional, Ikeda, K., additional, Ikeoka, K., additional, Imaizumi, M., additional, Inaba, H., additional, Inoue, T., additional, Iseki, F., additional, Ishihara, A., additional, Ishioka, N., additional, Ito, N., additional, Iwase, T., additional, Kakuda, H., additional, Kamata, J., additional, Kanai, H., additional, Kanda, H., additional, Kaneko, M., additional, Kano, H., additional, Kasai, T., additional, Kato, T., additional, Kato, Y., additional, Kawada, Y., additional, Kawai, K., additional, Kawakami, K., additional, Kawakami, S., additional, Kawamoto, T., additional, Kawano, S., additional, Kim, J., additional, Kira, T., additional, Kitazawa, H., additional, Kitazumi, H., additional, Kito, T., additional, Kobayashi, T., additional, Koeda, T., additional, Kojima, J., additional, Komatsu, H., additional, Komatsu, I., additional, Koshibu, Y., additional, Kotani, T., additional, Kozuka, T., additional, Kumai, Y., additional, Kumazaki, T., additional, Maeda, I., additional, Maeda, K., additional, Maruyama, Y., additional, Matsui, S., additional, Matsushita, K., additional, Matsuura, Y., additional, Mineoi, K., additional, Mitsuhashi, H., additional, Miura, N., additional, Miyaguchi, S., additional, Miyajima, S., additional, Miyamoto, H., additional, Miyashita, A., additional, Miyata, S., additional, Mizuguchi, I., additional, Mizuno, A., additional, Mori, T., additional, Moriai, O., additional, Morishita, K., additional, Murai, O., additional, Nagai, S. (Sho), additional, Nagai, S. (Shunichi), additional, Nagata, E., additional, Nagata, H., additional, Nakagomi, A., additional, Nakahara, S., additional, Nakamura, M., additional, Nakamura, R., additional, Nakanishi, N., additional, Nakayama, T., additional, Nakazato, R., additional, Nanke, T., additional, Nariyama, J., additional, Niijima, Y., additional, Niinuma, H., additional, Nishida, Y., additional, Nishihata, Y., additional, Nishino, K., additional, Nishioka, H., additional, Nishizawa, K., additional, Niwa, I., additional, Nomura, K., additional, Nomura, S., additional, Nozoe, M., additional, Ogawa, T., additional, Ohara, N., additional, Okada, M., additional, Okamoto, K., additional, Okita, H., additional, Okuyama, M., additional, Ono, H., additional, Ono, T., additional, Onuki Pearce, Y., additional, Oriso, S., additional, Ota, A., additional, Otaki, E., additional, Saito, Y., additional, Sakai, H., additional, Sakamoto, N., additional, Sakamoto, Y., additional, Samejima, Y., additional, Sasagawa, Y., additional, Sasaguri, H., additional, Sasaki, A., additional, Sasaki, T., additional, Sato, K. (Kazuki), additional, Sato, K. (Kiyoharu), additional, Sawano, M., additional, Seki, S., additional, Sekine, Y., additional, Seta, Y., additional, Sezaki, K., additional, Shibata, N., additional, Shiina, Y., additional, Shimono, H., additional, Shimoyama, Y., additional, Shindo, T., additional, Shinohara, H., additional, Shinohe, R., additional, Shinozuka, T., additional, Shirai, T., additional, Shiraiwa, T., additional, Shozawa, Y., additional, Suga, T., additional, Sugimoto, C., additional, Suzuki, K. (Kazuo), additional, Suzuki, K. (Keita), additional, Suzuki, S. (Shu), additional, Suzuki, S. (Shunji), additional, Suzuki, S. (Susumu), additional, Suzuki, Y., additional, Tada, M., additional, Taguchi, A., additional, Takagi, T., additional, Takagi, Y., additional, Takahashi, K., additional, Takahashi, S., additional, Takai, H., additional, Takanaka, C., additional, Take, S., additional, Takeda, H., additional, Takei, K., additional, Takenaka, K., additional, Tana, T., additional, Tanabe, G., additional, Taya, K., additional, Teragawa, H., additional, Tohyo, S., additional, Toru, S., additional, Tsuchiya, Y., additional, Tsuji, T., additional, Tsuzaki, K., additional, Uchiyama, H., additional, Ueda, O., additional, Ueyama, Y., additional, Wakaki, N., additional, Wakiyama, T., additional, Washizuka, T., additional, Watanabe, M., additional, Yamada, T., additional, Yamagishi, T., additional, Yamaguchi, H., additional, Yamamoto, K. (Kenichi), additional, Yamamoto, K. (Kentaro), additional, Yamamoto, K. (Kunihiko), additional, Yamamoto, T., additional, Yamaura, M., additional, Yamazoe, M., additional, Yasui, K., additional, Yokoyama, Y., additional, Yoshida, K., additional, Ching, C. K., additional, Foo, C. G., additional, Chow, J. H., additional, Chen, D. D., additional, Jaufeerally, F. R., additional, Lee, Y. M., additional, Lim, G., additional, Lim, W. T., additional, Thng, S., additional, Yap, S. Y., additional, Yeo, C., additional, Pak, H. N., additional, Kim, J.‐B., additional, Kim, J. H., additional, Jang, S.‐W., additional, Kim, D. H., additional, Ryu, D. R., additional, Park, S. W., additional, Kim, D.‐K., additional, Choi, D. J., additional, Oh, Y. S., additional, Cho, M.‐C., additional, Kim, S.‐H., additional, Jeon, H.‐K., additional, Shin, D.‐G., additional, Park, J. S., additional, Park, H. K., additional, Han, S.‐J., additional, Sung, J. H., additional, Cho, J.‐G., additional, Nam, G.‐B., additional, On, Y. K., additional, Lim, H. E., additional, Kwak, J. J., additional, Cha, T.‐J., additional, Hong, T. J., additional, Park, S. H., additional, Yoon, J. H., additional, Kim, N.‐H., additional, Kim, K.‐S., additional, Jung, B. C., additional, Hwang, G.‐S., additional, Kim, C.‐J., additional, Kim, D. B., additional, Ahn, J. J., additional, An, H. J., additional, Bae, H., additional, Baek, A. L., additional, Chi, W. J., additional, Choi, E. A., additional, Choi, E. H., additional, Choi, H. K., additional, Choi, H. S., additional, Han, S., additional, Heo, E. S., additional, Her, K. O., additional, Hwang, S. W., additional, Jang, E. M., additional, Jang, H.‐S., additional, Jang, S., additional, Jeon, H.‐G., additional, Jeon, S. R., additional, Jeon, Y. R., additional, Jeong, H. K., additional, Jung, I.‐A., additional, Kim, H. J. (Hyeon Jeong), additional, Kim, H. J. (Hyun Ju), additional, Kim, J. S. (Ji Seon), additional, Kim, J. S. (Jung Sook), additional, Kim, J. A., additional, Kim, K. T., additional, Kim, M. S., additional, Kim, S. H. (Sang Hee), additional, Kim, S. H. (Sang Hyun), additional, Kim, Y.‐I., additional, Lee, C. S., additional, Lee, E. H., additional, Lee, G. H., additional, Lee, H. Y., additional, Lee, H.‐Y., additional, Lee, K. H., additional, Lee, K. R., additional, Lee, M. S., additional, Lee, M.‐Y., additional, Lee, R. W., additional, Lee, S. E., additional, Lee, S. H., additional, Lee, S., additional, Lee, W. Y., additional, Noh, I. K., additional, Park, A. R., additional, Park, B. R., additional, Park, H. N., additional, Park, J. H., additional, Park, M., additional, Park, Y., additional, Seo, S.‐Y., additional, Shim, J., additional, Sim, J. H., additional, Sohn, Y. M., additional, Son, W. S., additional, Son, Y. S., additional, Song, H. J., additional, Wi, H. K., additional, Woo, J. J., additional, Ye, S., additional, Yim, K. H., additional, Yoo, K. M., additional, Yoon, E. J., additional, Yun, S. Y., additional, Chawanadelert, S., additional, Mongkolwongroj, P., additional, Kanokphatcharakun, K., additional, Cheewatanakornkul, S., additional, Laksomya, T., additional, Pattanaprichakul, S., additional, Chantrarat, T., additional, Rungaramsin, S., additional, Silaruks, S., additional, Wongcharoen, W., additional, Siriwattana, K., additional, Likittanasombat, K., additional, Katekangplu, P., additional, Boonyapisit, W., additional, Cholsaringkarl, D., additional, Chatlaong, B., additional, Chattranukulchai, P., additional, Santanakorn, Y., additional, Hutayanon, P., additional, Khunrong, P., additional, Bunyapipat, T., additional, Jai‐Aue, S., additional, Kaewsuwanna, P., additional, Bamungpong, P., additional, Gunaparn, S., additional, Hongsuppinyo, S., additional, Inphontan, R., additional, Khattaroek, R., additional, Khunkong, K., additional, Kitmapawanont, U., additional, Kongsin, C., additional, Naratreekoon, B., additional, Ninwaranon, S., additional, Phangyota, J., additional, Phrommintikul, A., additional, Phunpinyosak, P., additional, Pongmorakot, K., additional, Poomiphol, S., additional, Pornnimitthum, N., additional, Pumprueg, S., additional, Ratchasikaew, S., additional, Sanit, K., additional, Sawanyawisuth, K., additional, Silaruks, B., additional, Sirichai, R., additional, Sriwichian, A., additional, Suebjaksing, W., additional, Sukklad, P., additional, Suttana, T., additional, Tangsirira, A., additional, Thangpet, O., additional, Tiyanon, W., additional, Vorasettakarnkij, Y., additional, Wisaratapong, T., additional, Wongtheptien, W., additional, Wutthimanop, A., additional, Yawila, S., additional, Altun, A., additional, Ozdogru, I., additional, Ozdemir, K., additional, Yilmaz, O., additional, Aydinlar, A., additional, Yilmaz, M. B., additional, Yeter, E., additional, Ongen, Z., additional, Cayli, M., additional, Pekdemir, H., additional, Ozdemir, M., additional, Sucu, M., additional, Sayin, T., additional, Demir, M., additional, Yorgun, H., additional, Ersanli, M., additional, Okuyan, E., additional, Aras, D., additional, Abdelrahman, H., additional, Aktas, O., additional, Alpay, D., additional, Aras, F., additional, Bireciklioglu, M. F., additional, Budeyri, S., additional, Buyukpapuc, M., additional, Caliskan, S., additional, Esen, M., additional, Felekoglu, M. A., additional, Genc, D., additional, Ikitimur, B., additional, Karaayvaz, E. B., additional, Kılıç Karataş, S., additional, Okutucu, S., additional, Ozcelik, E., additional, Quisi, A., additional, Sag, H., additional, Sahiner, L., additional, Sayin, B. Y., additional, Seker, T., additional, Uzun Alkan, D., additional, Yildirim, E., additional, Yildirim, R., additional, Yilmaz, F., additional, Yuksekdag, V., additional, Vensentini, N., additional, Ingaramo, A. C., additional, Sambadaro, G. A., additional, Fernandez Caputi, V., additional, Berman, S. G., additional, Dragotto, P., additional, Kleiban, A. J., additional, Centurion, N., additional, Giacomi, G., additional, Ahuad Guerrero, R. A., additional, Conde, D., additional, Zapata, G., additional, Di Paola, L. A., additional, Ramos, J. L., additional, Dran, R. D., additional, Egido, J., additional, Fernandez, A. A., additional, Fosco, M. J., additional, Sassone, S., additional, Sinisi, V. A., additional, Cartasegna, L. R., additional, Berli, M. A., additional, Gomez Vilamajo, O. A., additional, Ferroni, F., additional, Alaguibe, E. D., additional, D'Amelio, A. Alvarez, additional, Arabetti, C., additional, Arias, L., additional, Belardi, J. A., additional, Bergesio, L., additional, Berli, F., additional, Berli, M., additional, Borchowiec, S., additional, Buzzetti, C., additional, Cabrini, R., additional, Campisi, V., additional, Cappi, A. L., additional, Carrizo, R., additional, Colombo Berra, F., additional, Costabel, J. P., additional, Costamagna, O. J. A., additional, Damonte, A. A., additional, De Urquiza, I. N., additional, Diez, F., additional, Edén, M. F., additional, Fanuele, M., additional, Fernandez Voena, F., additional, Foa Torres, M., additional, Funosas, C., additional, Giacomi, M. P., additional, Gimenez, C. H., additional, Gurfinkel, E. P., additional, Had, M. de L. M., additional, Hansen, V., additional, Hrabar, A. D., additional, Ingratta, M., additional, Lopez, A., additional, Maehara, G., additional, Maffei, L., additional, Martinelli, A., additional, Martinelli, C., additional, Matkovich, J., additional, Mautner, B., additional, Meirino, A., additional, Munguia, R., additional, Navarro, A., additional, Novas, V., additional, Prados, G. Perez, additional, Pontoriero, J., additional, Potito, R. N., additional, Ricotti, C., additional, Rodriguez, M. A., additional, Rolandi, F., additional, Palladino, . E. Said, additional, Salinger, M., additional, Sanziani, L. S., additional, Schygiel, P. O., additional, Sossich, A., additional, Tinto, J. F., additional, Tonelli, L., additional, Tufare, A. L., additional, Vallejo, M., additional, Yunis, M. E., additional, Zillo, M., additional, Zurbrigk, F. J., additional, Sobral Filho, D. C., additional, Jaber, J., additional, Armaganijan, D., additional, Faria Neto, J., additional, Steffens, A., additional, de Souza, W. Kunz Sebba Barroso, additional, de Souza Neto, J. D., additional, Ribeiro, J. M., additional, Silveira Teixeira, M., additional, Ferreira Rossi, P. R., additional, Pires, L., additional, Moreira, D., additional, Moura Jorge, J. C., additional, Lorga Filho, A. Menezes, additional, Bodanese, L. C., additional, Montera, M. Westerlund, additional, Del Carlo, C. H., additional, Da Rocha Rodrigues, T., additional, Alves da Costa, F. A., additional, Lopes, A., additional, Lopes, R., additional, Araújo, G. R., additional, Fernandes Manenti, E. R., additional, Kerr Saraiva, J. F., additional, Ferreira Braga, J. C., additional, Negri, A., additional, Souto, L., additional, Moncada, C., additional, Precoma, D. Bertolim, additional, Roquette, F., additional, Reis, G., additional, Ramos Filho, R. A., additional, Figueiredo, E. Lanna, additional, Botelho, R. Vieira, additional, Tavares, C. Munhoz da Fontoura, additional, Costantini Frack, C. R., additional, Abdalla Saad, J., additional, Finimundi, H. C., additional, Pisani, C., additional, Chemello, D., additional, Pereira Martins, M., additional, Broilo França, C. C., additional, Alban, F., additional, Aranha Rosito, G. B., additional, de Moura Xavier Moraes Junior, J. B., additional, Tumelero, R. T., additional, Maia, L. Nigro, additional, de Almeida, R. Simões, additional, do Carmo Borges, N. C., additional, Gomes Ferreira, L. G., additional, Agliardi, P., additional, de Oliveira Gomes, J. Alves, additional, Araujo, V., additional, Nakazone, M. Arruda, additional, Barbosa, T., additional, Barroso, S., additional, Falchetto, E. Belisario, additional, Lopes, H. Bellotti, additional, Benez Teixeira Lemos, M. A., additional, Biazus, G., additional, Borges Queiroz, L., additional, Camazzola, F. E., additional, Caporale, M., additional, Boscato, S. Cardoso, additional, Chieza, F., additional, Chokr, M. O., additional, Mingireanov, R. Clemente, additional, Góes, N. Codonho, additional, Correa, C., additional, Costa, M., additional, Costantini Ortiz, C., additional, da Silva, L. S., additional, da Silva Paulitsch, F., additional, da Silveira, J. A., additional, Daros, E., additional, de Araújo, G. R., additional, Del Monaco, M. I., additional, Dias, C., additional, Dias, M. A., additional, Drummond Wainstein, A. P., additional, Pizzato, P. Ely, additional, Esteves, D. C., additional, Fabri, P., additional, Félix Lorenzato Fonseca, T., additional, Fernandes, E., additional, Fonseca, C., additional, Costantini, C. R. Frack, additional, Ferraz, R. Franchin, additional, Freire, F., additional, Gottardo, P., additional, Guanaes, D., additional, Guizzardi, S., additional, Magedanz, E. Hettwer, additional, Igansi, F., additional, Jannuzzi, F., additional, Junior, G., additional, Komar, D., additional, Lino, E. G., additional, Lopes, D., additional, da Silva Júnior, O. Lourenço, additional, Lustosa, E., additional, Macagnan, A. P., additional, Marinho, M. C., additional, Mazzoni, M., additional, Melo, G., additional, Mortari, L., additional, Mouco, O. M. C. C., additional, Nanzer Vital, C., additional, Ormundo, C., additional, Oss Emmer, S., additional, Palmegiani, E., additional, Pavani, R., additional, Pereira, L., additional, Pereira, V. L., additional, Perreira, R., additional, Poletti, S., additional, Quaia Fortunato, S. C., additional, Queirantes, C., additional, Pereira, N. Ramos, additional, Rech, R. L., additional, Ribeiro, S., additional, Rodrigues, A., additional, Roesch, H., additional, Reichert, T. Ruaro, additional, Santos, D., additional, Santos, I., additional, Santos, M., additional, Seroqui, M. V., additional, Silva, S., additional, Soares, L., additional, Spolaor, L., additional, Stoll, C., additional, Duda, N. Toazza, additional, Trama, L., additional, Unterkircher, B., additional, Valois, M. V., additional, Vargas, T., additional, Viana, T., additional, Vicente, C., additional, Armaganijan, L. Vidal, additional, Homem, R. Vieira, additional, Vieira Torres, L. G., additional, Boas, L. Vila, additional, Guimarães Filho, F. Villaça, additional, Eggers, G., additional, Gutiérrez, C. Bugueño, additional, Arriagada, G., additional, Cardenas, S. Potthoff, additional, Stockins Fernandez, B. A. J., additional, Conejeros, C., additional, Houzvic, C., additional, Cuevas, P. Marin, additional, Montecinos, H., additional, Forero, A., additional, Lanas, F., additional, Gómez, M. Larico, additional, Vilches, G. Charme, additional, Rey, C., additional, Astudillo, C., additional, Aguilar, J., additional, Campisto, Y., additional, Lara, C., additional, Molina, E., additional, Oyarzon, J. Munoz, additional, Olguin, V., additional, Vergara, M., additional, Villan, C., additional, Illescas Diaz, J., additional, Leal Cantú, R., additional, Ramos Zavala, M. G., additional, Cabrera Jardines, R., additional, Espinola Zavaleta, N., additional, Villarreal Umaña, S., additional, López Rosas, E., additional, Llamas Esperón, G., additional, Pozas, G., additional, Cardona Muñoz, E., additional, Matadamas Hernández, N., additional, Leyva Rendón, A., additional, García Hernández, N., additional, de los Ríos Ibarra, M., additional, Virgen Carrillo, L., additional, López Villezca, D., additional, Hernández Herrera, C., additional, López Prieto, J. J., additional, Gaona Rodríguez, R., additional, Villeda Espinosa, E., additional, Flores Martínez, D., additional, Velasco Barcena, J., additional, Yong, R., additional, Rodríguez Briones, I., additional, Leiva Pons, J. L., additional, Álvarez López, H., additional, Olvera Ruiz, R., additional, Díaz de la Vega, C., additional, Cantú Brito, C., additional, Chuquiure Valenzuela, E., additional, Reyes‐Sanchez, R., additional, Bazzoni Ruiz, A., additional, Nandayapa Flores, O., additional, Benavides Gonzalez, M., additional, Arriaga Nava, R., additional, Morales Cerda, J. D., additional, Fierro Fierro, O., additional, Fajardo Campos, P., additional, Alfaro, T. A. A., additional, Altamirano Bellorin, S., additional, Avena, R., additional, Chavarria, M., additional, Espinosa, I., additional, Flores Silva, F., additional, Garcia Nava, R. H., additional, Godoy, K., additional, Gonzalez Felix, E. J., additional, Gonzalez Garcia, C. L., additional, Gonzalez Salas, L. G., additional, Guajardo, P., additional, Hernandez Gonzalez, S., additional, Izquierdo, T., additional, Mancilla Ortiz, M. C., additional, Martinez Vasquez, D., additional, Mendoza, N., additional, Morales, J., additional, Nikitina, N., additional, Ochoa Aybar, S., additional, Ortiz, A., additional, Padilla Macias, P., additional, Perez, F., additional, Perez Sanchez, J. A., additional, Piña Toledano, S., additional, Ramos Gonzalez, M., additional, Rivera Ramos, C., additional, Roa Castro, V., additional, Romero Cardona, G., additional, Ruiz Cornejo, M., additional, Salinas, A., additional, Santana, G., additional, Sida Perez, P., additional, Tovar Castaneda, A. C., additional, Trujillo Cortes, R., additional, Lenz, K., additional, Drexel, H., additional, Foechterle, J., additional, Hagn, C., additional, Podczeck‐Schweighofer, A., additional, Huber, K., additional, Winkler, M., additional, Schneeweiß, B., additional, Gegenhuber, A., additional, Lang, W., additional, Eichinger‐Hasenauer, S., additional, Kaserer, P., additional, Sykora, J., additional, Rasch, H., additional, Pichler, M., additional, Schaflinger, E., additional, Strohmer, B., additional, Breier, R., additional, Ebner, K.‐M., additional, Eischer, L., additional, Freihoff, F., additional, Lischka‐Lindner, A., additional, Mark, T., additional, Mirtl, A., additional, Said, A., additional, Stöcklöcker, C., additional, Vogel, B., additional, Vonbank, A., additional, Wöhrer, C., additional, Zanolin, D., additional, Paparella, G., additional, Vandergoten, P., additional, Parqué, J.‐L., additional, Capiau, L., additional, Vervoort, G., additional, Wollaert, B., additional, Desfontaines, P., additional, Mairesse, G., additional, Boussy, T., additional, Godart, P., additional, De Wolf, A., additional, Voet, J., additional, Heyse, A., additional, Hollanders, G., additional, Anné, W., additional, Vercammen, J., additional, Purnode, P., additional, Blankoff, I., additional, Faes, D., additional, Balthazar, Y., additional, Beutels, M., additional, Maréchal, P., additional, Verstraete, S., additional, Xhaet, O., additional, Striekwold, H., additional, Thoeng, J., additional, Hermans, K., additional, Alzand, B., additional, Ascoop, A.‐K., additional, Banaeian, F., additional, Barbuto, A.‐M., additional, Billiaux, A. C., additional, Blockmans, M., additional, Bouvy, C., additional, Brike, C., additional, Capiau, H., additional, Casier, T., additional, Conde Y Bolado, A., additional, De Cleen, D., additional, De Coninck, M., additional, de Vos, M., additional, de Weerdt, N., additional, Delforge, M., additional, Delvigne, M., additional, Denie, D., additional, Derycker, K., additional, Deweerd, E., additional, Dormal, F., additional, Drieghe, S., additional, Everaert, M., additional, Eykerman, T., additional, Feys, E., additional, Ghekiere, M., additional, Gits, F., additional, Hellemans, S., additional, Helvasto, L., additional, Jacobs, C., additional, Lips, S., additional, Mestdagh, I., additional, Nimmegeers, J., additional, Piamonte, V., additional, Pollet, P., additional, Postolache, A., additional, Raepers, M., additional, Raymenants, E., additional, Richa, J., additional, Rombouts, H., additional, Salembier, J., additional, Scheurwegs, C., additional, Semeraro, O., additional, Simons, N., additional, Smessaert, C., additional, Smolders, W., additional, Stockman, I., additional, Tahon, S., additional, Thyssen, V., additional, Tincani, G., additional, Van Durme, F., additional, Van Lier, D., additional, Vandekerckhove, H., additional, Vandekerckhove, Y., additional, Vandenbroeck, D., additional, Vandorpe, A., additional, Vanhalst, E., additional, Vanhauwaert, B., additional, Vantomme, C., additional, Vergauwen, L., additional, Verloove, H., additional, Vydt, T., additional, Weyn, T., additional, Reichert, P., additional, Spacek, R., additional, Machova, V., additional, Zidkova, E., additional, Ludka, O., additional, Olsr, J., additional, Kotik, L., additional, Plocova, K., additional, Racz, B., additional, Ferkl, R., additional, Hubac, J., additional, Kotik, I., additional, Monhart, Z., additional, Burianova, H., additional, Jerabek, O., additional, Pisova, J., additional, Petrova, I., additional, Dedek, V., additional, Honkova, M., additional, Podrazil, P., additional, Spinar, J., additional, Vitovec, J., additional, Novak, M., additional, Lastuvka, J., additional, Durdil, V., additional, Antonova, P., additional, Bockova, L., additional, Bultas, J., additional, Chlumsky, J., additional, Dastychova, L., additional, Drasnar, T., additional, Honek, J., additional, Horejsi, M., additional, Hubacova, V., additional, Janska, L., additional, Kopeckova, I., additional, Kratochvilova, R., additional, Krcova, E., additional, Labrova, R., additional, Lindourkova, A., additional, Lipoldova, J., additional, Lubanda, H., additional, Ludkova, A., additional, Mahdalikova, L., additional, Majerníkova, M., additional, Michalik, D., additional, Potuznik, P., additional, Prochazkova, E., additional, Sulc, A., additional, Sveceny, J., additional, Valtova, M., additional, Zidek, M., additional, Zika, J., additional, Nielsen, H., additional, Husted, S., additional, Hintze, U., additional, Rasmussen, S., additional, Bremmelgaard, A., additional, Markenvard, J., additional, Boerger, J., additional, Solgaard, J., additional, Simonsen, P., additional, Loekkegaard, T., additional, Bruun, M., additional, Mertz, J., additional, Domínguez, H., additional, Skagen, K., additional, Egstrup, K., additional, Raymond, H. Ibsen I., additional, Bang‐Hansen, T., additional, Ellervik, C., additional, Eriksen, E., additional, Jensen, L., additional, Jensen, M., additional, Leth, M., additional, Nygaard, A., additional, Park, J., additional, Schou, M., additional, Therkelsen, A., additional, Tilma, J., additional, Vesterager, K., additional, Airaksinen, J., additional, Arola, O., additional, Koistinen, J., additional, Nappila, H., additional, Peltomäki, K., additional, Rasanen, V., additional, Vasankari, T., additional, Le Heuzey, J.‐Y., additional, Galinier, M., additional, Gottwalles, Y., additional, Paganelli, F., additional, Loiselet, P., additional, Muller, J.‐J., additional, Koujan, M. B., additional, Marquand, A., additional, Destrac, S., additional, Piot, O., additional, Delarche, N., additional, Cebron, J.‐P., additional, Boveda, S., additional, Guenoun, M., additional, Guedj‐Meynier, D., additional, Galley, D., additional, Ohayon, J., additional, Assouline, S., additional, Zuber, M., additional, Amarenco, P., additional, Ellie, E., additional, Kadouch, J., additional, Fournier, P.‐Y., additional, Huberman, J.‐P., additional, Lemaire, M., additional, Rodier, G., additional, Milandre, L., additional, Vandamme, X., additional, Sibon, I., additional, Neau, J.‐P., additional, Mahagne, M. H., additional, Mielot, A., additional, Bonnefoy, M., additional, Churet, J.‐B., additional, Navarre, V., additional, Sellem, F., additional, Monniot, G., additional, Boyes, J.‐P., additional, Doucet, B., additional, Martelet, M., additional, Obadia, D., additional, Crousillat, B., additional, Mouallem, J., additional, Bearez, E., additional, Nazeyrollas, P., additional, Brugnaux, J. P., additional, Fedorowsky, A., additional, Casassus, F., additional, Berneau, J.‐B., additional, Chemin, F., additional, Falvo, N., additional, Perron, J.‐M., additional, Poulard, J.‐E., additional, Barreau, A., additional, Beltra, C., additional, Corrihons, E., additional, Decarsin, N., additional, Dubois, B., additional, Ducasse, E., additional, Giry, X., additional, Kemmel, A., additional, Ledure, S., additional, Lemaire, N., additional, Robin, F., additional, Rosolin, N., additional, Sanchez, D., additional, Suissa, A., additional, Königer, G., additional, Purr, J., additional, Gerbaulet, U., additional, Kellner, B.‐T., additional, Kopf, A., additional, Schäfer, T., additional, Zauzig, H., additional, Riegel, P., additional, Hohensee, H., additional, Eißfeller, E., additional, Eder, W., additional, Rehling, G., additional, Glatzel, D., additional, Zutz, S., additional, Heinz, G.‐U., additional, Menke, H., additional, Pustelnik, A., additional, Sandow, P., additional, Ludwig, N., additional, Wiswedel, H., additional, Wildenauer, W., additional, Axthelm, C., additional, Schwarz, T., additional, Babyesiza, A., additional, Stuchlik, G., additional, Zimny, H.‐H., additional, Kropp, M., additional, Kahl, F., additional, Caspar, A., additional, Omankowsky, S., additional, Läßig, T., additional, Hartmann, H.‐J., additional, Lehmann, G., additional, Bindig, H.‐W., additional, Hergdt, G., additional, Reimer, D., additional, Hauk, J., additional, Dorsch, W., additional, Dshabrailov, J., additional, Michel, H., additional, Rapp, K.‐A., additional, Vormann, R., additional, Mayer, P., additional, Horstmeier, U., additional, Eissing, V., additional, Hey, H., additional, Leuchtgens, H., additional, Lilienweiß, V., additional, Kolitsch, K., additional, Schubert, C., additional, Lauer, H., additional, Buchner, T., additional, Brauer, G., additional, Kamin, S., additional, Müller, K., additional, Abdel‐Qader, M., additional, Baumbach, S., additional, Ebert, H.‐H., additional, Schwencke, C., additional, Schellong, S., additional, Bernhardt, P., additional, Karolyi, L., additional, Sievers, B., additional, Haverkamp, W., additional, Salbach, P., additional, Röhnisch, J.‐U., additional, Schoen, S., additional, Erdle, W., additional, Mueller, T., additional, Mueller, H., additional, Mitrovic, V., additional, Babjakova, Z., additional, Bergner, K., additional, Boehme, S., additional, Bonin, K., additional, Buckert, D., additional, Busch, F., additional, Dichristin, U., additional, Diez, S., additional, Fleck, A., additional, Flint, K., additional, Floegel, H., additional, Fritz, C., additional, Frommhold, R., additional, Gehre, J., additional, Geyer, J., additional, Grytzmann, A., additional, Hahn, M., additional, Helgert, K., additional, Hubert, K., additional, Kirchner‐Volker, K., additional, Klein, V., additional, Kroll, D., additional, Krueger, A., additional, Lehmann, R., additional, Mann, L., additional, Maselli, A., additional, Menken, G., additional, Mikes, K., additional, Mortan, H., additional, Nasser, N., additional, Nicolaus, D., additional, Plauskat, A., additional, Pomper, L., additional, Quietzsch, A., additional, Ravenhorst, C., additional, Reichelt, C., additional, Reimer, C., additional, Schaefer, B., additional, Scharrer, S., additional, Schirmer, K., additional, Schmidt, K., additional, Schoene, R., additional, Schulze, J., additional, Schuppe, M., additional, Simon, S., additional, Sommer, S., additional, Spranger, K., additional, Talkenberger, A., additional, Tauber, K., additional, Tetlak, A., additional, Toennishoff, T., additional, Voelkel‐Babyesiza, R., additional, Voigts, B., additional, Weiser, U., additional, Wesendorf, S., additional, Wildenauer, S., additional, Wolf, T., additional, Wurziger, J., additional, Zak, J., additional, Zauzig, H.‐D., additional, Ziefle, S., additional, Zincke, S., additional, Vangel, S., additional, Szalai, G., additional, Merkely, B., additional, Kancz, S., additional, Boda, Z., additional, Nagy, A., additional, Laszlo, Z., additional, Matoltsy, A., additional, Gaszner, B., additional, Polgar, P., additional, Habon, T., additional, Noori, E., additional, Juhasz, G., additional, Kanakaridisz, N., additional, Szentpeteri, I., additional, Juhasz, F., additional, Vertes, A., additional, Papp, A., additional, May, Z., additional, Ferenczi, J., additional, Egyutt, M., additional, Kis, E., additional, Engelthaler, G., additional, Szantai, G., additional, Fulop, E., additional, Gombos, P., additional, Gulyas, D., additional, Jen, P., additional, Kiralyhazine Gyorke, E., additional, Kovacs, M., additional, Kovacsne Levang, S., additional, Marianna, S., additional, Radics, Z., additional, Sydó, N., additional, Szalo, R., additional, Szilagyi, A., additional, Sztanyik, F., additional, Vandrus, B., additional, Rangel, G., additional, Bosman, F., additional, Bosschaert, M., additional, Bruin, S., additional, Danse, I., additional, De Graaf, J., additional, de Graauw, J., additional, Debordes, M., additional, Dols, S., additional, Geerlings, F., additional, Gorrebeeck, K., additional, Jerzewski, A., additional, Jetten, W., additional, Kelderman, M., additional, Kloosterman, T., additional, Koomen, E. M., additional, Krikken, J., additional, Melman, P., additional, Mulder, R., additional, Pronk, A., additional, Stallinga‐de Vos, A., additional, te Kaat, J., additional, Tonino, P., additional, Uppelschoten, B., additional, van de Loo, R., additional, van der Kley, T., additional, van Leeuwen, G., additional, van Putten, J. J., additional, Westerman, L., additional, Berge, E., additional, Sirnes, P. A., additional, Gjertsen, E., additional, Hole, T., additional, Erga, K., additional, Hallaråker, A., additional, Skjelvan, G., additional, Østrem, A., additional, Ghezai, B., additional, Svilaas, A., additional, Christersson, P., additional, Øien, T., additional, Høegh Henrichsen, S., additional, Berg‐Johansen, J., additional, Otterstad, J. E., additional, Antonsen, H., additional, Ausen, K., additional, Claussen, H., additional, Dominguez, I., additional, Jekthammer, A., additional, Lensebraaten, A. B., additional, Nilsen, V., additional, O'Donovan, M., additional, Ringdalen, K., additional, Strand, S., additional, Korzeniak, R., additional, Gieroba, A., additional, Biedrzycka, M., additional, Ogorek, M. (Marcin), additional, Wozakowska‐Kaplon, B., additional, Loboz‐Grudzien, K., additional, Kosior, J., additional, Supinski, W., additional, Kuzniar, J., additional, Zaluska, R., additional, Hiczkiewicz, J., additional, Swiatkowska‐Byczynska, L., additional, Kucharski, L., additional, Gruchala, M., additional, Minc, P., additional, Olszewski, M., additional, Kania, G., additional, Krzciuk, M., additional, Lajkowski, Z., additional, Ostrowska‐Pomian, B., additional, Lewczuk, J., additional, Zinka, E., additional, Karczmarczyk, A., additional, Chmielnicka‐Pruszczynska, M., additional, Trusz‐Gluza, M., additional, Opolski, G., additional, Bronisz, M., additional, Ogorek, M. (Michal), additional, Glanowska, G., additional, Ruszkowski, P., additional, Jaworska, K., additional, Sciborski, R., additional, Okopien, B., additional, Kukla, P., additional, Wozniak‐Skowerska, I., additional, Galbas, K., additional, Cymerman, K., additional, Jurowiecki, J., additional, Miekus, P., additional, Myszka, W., additional, Mazur, S., additional, Lysek, R., additional, Baszak, J., additional, Rusicka‐Piekarz, T., additional, Raczak, G., additional, Domanska, E., additional, Nessler, J., additional, Lesnik, J., additional, Ambicka, M., additional, Andrzejewski, D., additional, Araminowicz, J., additional, Barszcz, A., additional, Bartkowiak, R., additional, Bartnik, J., additional, Basiak, M., additional, Bekieszczuk, E., additional, Bernat, L., additional, Biedrzycki, L., additional, Biernacka, A., additional, Blaszczyk, D., additional, Broton, E., additional, Brzozowski, W., additional, Brzustowska, M., additional, Bzymek, R., additional, Chmielowski, A., additional, Chojnowski, P., additional, Cichomski, R., additional, Cieslak, K., additional, Cieszynska, A., additional, Curyllo, B., additional, Czamara, M., additional, Danilowicz‐Szymanowicz, L., additional, Dolecka, B., additional, Drelich, L., additional, Dudzik‐Richter, B., additional, Dybala, T., additional, Dziuba, M., additional, Faron, W., additional, Figura‐Chmielewska, M., additional, Frankiewicz, A., additional, Gadzinski, W., additional, Gasior, E., additional, Gosciniecka, B., additional, Gutknecht, P., additional, Guziewicz, M., additional, Jackun‐Podlesna, A., additional, Jaguszewska, G., additional, Jankielewicz, J., additional, Jaremczuk‐Kaczmarczyk, A., additional, Jargiello‐Baszak, M., additional, Jarzebowski, A., additional, Jaskulska‐Niedziela, E., additional, Jaworska‐Drozdowska, M., additional, Kabat, J., additional, Kaczmarzyk‐Radka, A., additional, Kalin, K., additional, Kaliszczak, R., additional, Kiliszek, M., additional, Klata, M., additional, Kluczewski, M., additional, and Kobielusz‐Gembala, I., additional

Published
2019
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44. Decorating graphene nanosheets with electron accepting pyridyl-phthalocyanines

Author

Maria G. P. M. S. Neves, João P. C. Tomé, Dirk M. Guldi, Leandro M. O. Lourenço, Georgios Katsukis, Alexandra Roth, José A. S. Cavaleiro, Leonie Wibmer, and Tomás Torres

Subjects
Materials science, Graphene, Nanotechnology, Context (language use), Photochemistry, Exfoliation joint, law.invention, Photoexcitation, Electron transfer, symbols.namesake, law, Ultrafast laser spectroscopy, symbols, General Materials Science, Spectroscopy, Raman spectroscopy
Abstract

We describe herein the preparation of novel exfoliated graphene–phthalocyanine nanohybrids, and the investigation of their photophysical properties. Pyridyl-phthalocyanines (Pcs) 1–3 are presented as novel electron accepting building blocks of variable strengths with great potential for the exfoliation of graphite via their immobilization onto the basal plane of graphene in dimethylformamide (DMF) affording single layered and turbostratic graphene based G1–G3. G1–G3 were fully characterized (AFM, TEM, Raman, steady-state and pump probe transient absorption spectroscopy) and were studied in terms of electron donor–acceptor interactions in the ground and excited states. In this context, electron transfer upon photoexcitation from graphene to the electron accepting Pcs with dynamics, for example, in G2 of

Published
2015

45. Gross Chemical Profile and Calculation of Nitrogen-to-Protein Conversion Factors for Five Tropical Seaweeds

Author

João Oiano-Neto, Sidney Pacheco, Sergio O. Lourenço, Elisabete Barbarino, Graciela S. Diniz, GRACIELA S. DINIZ, DEPTO. BIOLOGIA MARINHA, UFF, RJ., ELISABETE BARBARINO, DETO. BIOLOGIA MARINHA, UFF, RJ., JOAO OIANO NETO, CPPSE, SIDNEY PACHECO, CTAA, and SERGIO O. LOURENÇO, DEPTO. BIOLOGIA MARINHA, UFF, RJ.

Subjects
Nitrogen to Protein Conversion Factors, chemistry.chemical_classification, Chaetomorpha aerea, biology, Protein, Tropical Environment, Phosphorus, chemistry.chemical_element, Seaweeds, General Medicine, Red algae, Element Composition, biology.organism_classification, Nitrogen, Amino acid, Amino Acid, Algae, chemistry, Botany, Asparagopsis taxiformis, Chemical composition
Abstract

Despite decades of research on marine algae, there are still significant gaps in basic knowledge about chemical com-position of these organisms, especially in tropical environments. In this study, the amino acid composition and contents of total nitrogen, phosphorus, lipid, carbohydrate and protein were determined in Asparagopsis taxiformis, Centroceras clavulatum, Chaetomorpha aerea, Sargassum filipendula and Spyridia hypnoides. The seaweeds showed low lipid con-tents (lower than 5.5% d.w. in all species) and were rich in carbohydrates (more than 16% d.w. in all seaweeds). The percentage of nitrogen, phosphorus and protein varied widely among species, which red algae showed the highest con-centrations. The amino acid composition was similar among the seaweeds, which glutamic acid, aspartic acid and leu-cine as the most abundant. All species are poor in histidine. An average of 24.2% of the total nitrogen is non-proteinaceous. From data of total amino acid and total nitrogen, specific nitrogen-to-protein conversion factors were calculated for each species. The nitrogen-to-protein conversion factors calculated ranged from 4.51 to 5.21, with an overall average of 4.86. These findings show that the traditional conversion factor of 6.25 should be avoided for seaweeds, since it overestimates the actual protein content. Made available in DSpace on 2022-07-26T18:19:50Z (GMT). No. of bitstreams: 1 PROCIJON2011.00116.pdf: 353511 bytes, checksum: 348eb05b8e4656debd9db211fda48603 (MD5) Previous issue date: 2011

Published
2011

46. Muscular and Metabolic Responses to Resistance-Training with Eccentric Overload

Author

Bernardo Neme Ide, o Lourenço, Thiago Fern, René Brenzikofer, and Denise Vaz de Macedo

Subjects
Gerontology, business.industry, Strength training, Endurance training, Anesthesia, Maximal strength, Resistance training, Medicine, Eccentric, VO2 max, business, Respiratory compensation
Abstract

Objective: The main aim of the study was to observe the responses to a resistance-training program with an eccentric overload (EO) on muscular and metabolic parameters determinants for endurance training performance. Methods: Eight physically active subjects (3 women - age: 23.8 ±2.6 years; body mass: 70.9 ± 12.7 kg; height: 1.6 ± 0.08 m; % body fat: 29.6 ± 4.3; and 5 men - age: 23.8 ± 2.6 years; body mass: 75.1 ± 11.2 kg; height: 1.8 ± 0.1 m; % body fat: 20.0 ± 4.9) performed thirteen EO sessions twice a week and 48 hours apart. Maximal strength (MS), strength endurance (SE), and maximal oxygen consumption (VO2) tests were performed prior the beginning of the program, 96 hours Post the last training session (P13), seven and fourteen days afterwards as well (7D, and 14D). Results: The main findings of this study were MS presented significant (P

Published
2017

47. Synthesis, characterization and electrochemical properties of meso-thiocarboxylate-substituted porphyrin derivatives

Author

João P. C. Tomé, Kelly Aparecida Dias de Freitas Castro, Mário Lima, António F. da Cunha, Shirley Nakagaki, Bernardo A. Iglesias, José A. S. Cavaleiro, Maria G. P. M. S. Neves, Joao Resende, and Leandro M. O. Lourenço

Subjects
chemistry.chemical_element, General Chemistry, Photochemistry, Electrochemistry, Sulfur, Combinatorial chemistry, Porphyrin, Characterization (materials science), chemistry.chemical_compound, chemistry, Nucleophile, Atom, Fluorine, Molecule
Abstract

Considering the versatility of 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin (TPPF20) to react with nucleophiles we highlight here the synthesis and characterization of several mono- and tetra-thiocarboxylate derivatives. The selective displacement of the para-fluorine groups in TPPF20 by thiocarboxylic acids demonstrates that TPPF20 is an ideal platform for the rapid formation of thiocarboxylate porphyrins. The optical and electrochemical features of the thiocarboxylate derivatives were also examined thinking on their potential use in photovoltaic devices. From their electrochemical characterization the following parameters were taken into account: (i) electronegative induced effect of the thiocarboxylate dyes owing the presence of the fluorine and sulfur atoms on the molecular structure of the porphyrin; and (ii) the free rotation and flexibility features that such S atom gives to the porphyrin relatively to the semiconductor.

Published
2014

48. Proximate composition of marine invertebrates from tropical coastal waters, with emphasis on the relationship between nitrogen and protein contents

Author

Sergio O. Lourenço, Graciela S. Diniz, Elisabete Barbarino, Sidney Pacheco, and João Oiano-Neto

Subjects
chemistry.chemical_classification, biology, Echinometra lucunter, Phosphorus, chemistry.chemical_element, Marine invertebrates, Aquatic Science, Oceanography, biology.organism_classification, Amino acid, chemistry, Dry weight, Botany, Mollusca, Invertebrate, Lytechinus variegatus
Abstract

The chemical profiles of Desmapsamma anchorata, Hymeniacidon heliophila (Porifera), Bunodosoma caissarum, Renilla muelleri (Cnidaria), Aplysia brasiliana, Eledone massyae, Isognomon bicolor (Mollusca), Echinaster brasiliensis, Echinometra lucunter, Holothuria grisea, Lytechinus variegatus (Echinodermata), and Phallusia nigra (Chordata) were determined. Hydrosoluble protein was the most abundant class of substances for all species, except for the ascidian Phallusia nigra, in which the carbohydrate content was higher. The percentages of hydrosoluble protein (dry weight, dw) varied widely among the invertebrates, ranging from 5.88% (R. muelleri) to 47.6% (Eledone massyae) of the dw .The carbohydrate content fluctuated from 1.3% (R. muelleri) to 18.4% (Aplysia brasiliana) of the dw. For most of the species, lipid was the second most abundant class of substances, varying from 2.8% (R. muelleri) to 25.3% (Echinaster brasiliensis) of the dw. Wide variations were also found for the invertebrates nitrogen content, with the lowest value recorded in the cnidarian R. muelleri (2.02% of the dw) and the highest in the molluscan E. massyae (12.7% of the dw). The phosphorus content of the dw varyed from 0.24% (R. muelleri) to 1.16% (E. massyae). The amino acid composition varied largely among the species, but for most of the species glycine, arginine, glutamic acid, and aspartic acid were the most abundant amino acids, with histidine and tyrosine among the less abundant amino acids. The actual content of total protein in the samples was calculated by the sum of amino acid residues, establishing dw values that fluctuated from 11.1% (R. muelleri) to 66.7% (E. massyae). The proteinaceous nitrogen content was high in all species, with an average value of 97.3% of the total nitrogen. From data of total amino acid residues and total nitrogen, specific nitrogen-to-protein conversion factors were calculated for each species. The nitrogen-to-protein conversion factors ranged from 5.10 to 6.15, with an overall average of 5.45. The use of the specific nitrogen-to-protein conversion factors established here is recommended, since it would yield more accurate determinations of total protein in the species tested in this study.

Published
2014

49. An assessment of the usefulness of the cyanobacterium Synechococcus subsalsus as a source of biomass for biofuel production

Author

Fabio B. Passos, Elisabete Barbarino, Sergio O. Lourenço, and Bruno R.S. Setta

Subjects
productivity, QH301-705.5, chemistry.chemical_element, Biomass, SH1-691, Context (language use), biodiesel, GC1-1581, Aquatic Science, Oceanography, cyanobacteria, chemistry.chemical_compound, Laboratory flask, cianobacteria, lipid, cultivo, Aquaculture. Fisheries. Angling, Food science, Biology (General), lípidos, productividad, biology, biomass, Phosphorus, microalgae, Synechococcus, biology.organism_classification, Nitrogen, biomasa, chemistry, cultivation, microalgas, Biodiesel production, Carbon dioxide
Abstract

Nowadays algal biofuels are considered one of the most promising solutions of global energy crisis and climate change for the years to come. By manipulation of the culture conditions, many algal species can be induced to accumulate high concentrations of particular biomolecules and can be directed to the desired output for each fuel. In this context, the present study involved the assessment of the effects of CO 2 availability and nitrogen starvation on growth and chemical composition of the cyanobacterium Synechococcus subsalsus , testing a fast-growing native strain. The control experiments were performed with Conway culture medium in 12-day batch cultures, in 6-liter flasks and 12 h photoperiod, with addition of 2 L min -1 filtered air to each flask. Other two experimental conditions were also tested: (i) the placement into the cultures of additional dissolved nutrients except nitrogen, one week after the start of growth (N-), and (ii) the input of pure CO 2 into the flasks from the 5th day of growth (C+). In all cultures, daily cell counts were done throughout the cultivation, as well as measurements of pH and cell biovolumes. Maximum cell yield were found in N-experiments, while cell yields of C+ and control were similar. Dissolved nitrogen was exhausted before the end of the experiments, but dissolved phosphorus was not totally consumed. Protein and chlorophyll-a concentrations decreased from the exponential to the stationary growth phase of all experiments, except for protein in the control. In all experiments, carbohydrate, lipid and total carotenoid increased from the exponential to the stationary growth phase, as an effect of nitrogen limitation. Increments in carbohydrate concentrations were remarkable, achieving more than 42% of the dry weight (dw), but concentrations of lipid were always lower than 13% dw. The addition of pure CO 2 did not cause a significant increase in biomass of S. subsalsus nor generated more lipid and carbohydrate than the other treatments. Nitrogen starvation caused an intense accumulation of carbohydrate, but the increments of lipid were small. Despite the fast growth, the cyanobacterium S. subsalsus has a virtually null potential for biodiesel production, given its low lipid concentrations. The high concentrations of carbohydrate combined with fast growth point to the potential use of this species as raw material for other possible biotechnological processes, after a demonstration of technical and economic viability.

Published
2014

50. Synthetic approaches to glycophthalocyanines

Author

João P. C. Tomé, Maria G. P. M. S. Neves, Leandro M. O. Lourenço, and José A. S. Cavaleiro

Subjects
chemistry.chemical_compound, Aqueous solution, chemistry, biology, Singlet oxygen, Organic Chemistry, Drug Discovery, PEG ratio, biology.protein, Organic chemistry, Diglyme, Bovine serum albumin, Biochemistry
Published
2014

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