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A spatial sampling design determines where sample locations are placed in a study area so that population parameters can be estimated with good precision. Spatially balanced designs draw samples with good spatial spread and provide precise results for commonly used estimators when surveying natural resources. In this article, we propose a new sampling strategy that incorporates ranking information from nearby locations into a spatially balanced sample. If the population exhibits spatial trends, our simple local ranking strategy can improve the precision of commonly used estimators. Numerical results on several test populations with different spatial structures show that local ranking can improve the performance of a spatially balanced design. To show that local ranking is simple and effective in practice, we provide an example application for the health and productivity assessment of a Shiraz vineyard in South Australia.Supplementary materials accompanying this paper appear online.

Digitalization of business processes of personnel management is investigated in this paper. The digital transformation of personnel management has changed the company’s business processes, created a digital work environment, and introduced modern digital technologies. Therefore, it is important to identify modern ways of digitizing business processes of personnel management by using HRM-systems, as well as identify their functionality and capabilities. Digital transformation of business processes in HR management through social, mobile, analytical and cloud technologies allows to optimize work with paper documents, improve procedures and operations of personnel management, reduce their complexity, make all HR activities more mobile. This makes it possible not only to improve the involvement and retention of employees, but also significantly increase the success of the company through continuous transformation, which is important for business as a whole. Capabilities of modern domestic and foreign HRM-systems are analyzed and their advantages and disadvantages are identified in this paper. Comparative analysis of modern HRM-systems allows to generalize the possibilities for automating personnel management’s main business processes. Recommendations for evaluating the effectiveness of HRM-systems into practice of modern company’s personnel management are proposed. Key areas and indicators that characterize the features of software for personnel management automation are identified. Implementation of the initiative on digital transformation of HR-processes is an important task for enterprises. In practice, it is crucial issue to have an assessment of the real picture for digitization process and its effectiveness. The digitalization of personnel management’s business processes involves the usage of platforms for personnel, which offer functionality to automate many HR processes. Companies use HRM-systems, which allow managing key HR-functions within centralized system that optimizes personnel management’s business processes and reporting. HRM systems are the most important applications used in companies of all sizes and in all types of economic activities. The methods and the ways for evaluating the effectiveness of HR-processes’ digitization are not yet sufficiently investigated, which in turn, gives prospects for further research in this area.

Today, it is relevant to search for new, better methods of surgical treatment of tumors and organ-preserving and video-assisted surgery is gaining more and more popularity. The aim of the study was to improve the results of surgical treatment of children with primary and secondary (metastatic) lung tumors using high-frequency live tissue welding (HF LTW) in order to increase the treatment effectiveness. Novelty of the study lies in the expanding the knowledge of the new researched method, for enhancement of survivability relatively to chemotherapy and radiation methods, that are studied in the previous works. Advantages of the introduced method are bloodless, fast, low traumatic operations 103 case reports in children with primary and metastatic lung tumors were analyzed, including 34 patients with benign and malignant lung tumors and 69 children with metastatic bronchial and pulmonary lesions undergoing treatment from 2002 to 2018 were examined. Benign lung tumors were diagnosed in 17 patients. Malignant tumors were observed in 17 patients, including 11 lung carcinoid tumors. Metastatic bronchial and pulmonary lesions most often occurred with osteosarcoma (28) and nephroblastoma (17). In 34 children with primary tumors, 37 were undergone surgical interventions. Most often, atypical resection was used – 16 (43.3%), in particular, with carcinoid – in 7 (43.8%) patients and with hamartoma – in 4 (25%) patients. In metastatic lesions, in most cases, the same resection was performed. From 58 resections 25 (43%) were performed for osteosarcoma and 15 (26%) for nephroblastoma. The HF LTW method was used in 29 patients for benign and malignant primary tumors and in 62 (73%) surgical procedures for lung metastases to remove a tumor, vascular coagulation and sealing of the lung tissue. Using HF LTW surgical operations of different directions and volumes can be performed effectively in benign, malignant and metastatic bronchial and pulmonary lesions in children.

A system of two differential equations which describes the movement of fluid in a pipe with a variable flow rate and the conditions for the fluid outflow through the walls of drainage pipelines into the surrounding soil is considered. It is reasoned that the second term in the original equation, which takes into account energy losses associated with a flow rate variation along the length, can be neglected without a substantial error. The considered system is reduced to dimensionless form by introducing original variables. The coefficient of collecting drainage pipeline resistance «ζl» and the generalized parameter «A», which take into account the structural and hydraulic characteristics of the considered flow, are two main parameters used in the analysis. The concept of an infinitely long drainage pipeline (a pipeline with an infinite walls filtration capacity) is introduced in the article. Also it is noted that such pipeline will have a maximum throughput comparing to pipes of the same diameter but limited length. Quite simple and practical calculated dependencies for the determination of the nature of flow rate variation and pressure drop along the length of the pipeline were received on the basis of the conducted analysis. Important characteristics of pressure distribution pipelines were calculated on the basis of offered formulas. Corresponding graphical dependencies were built for visibility. In particular, graphs of the flow rate variation at the end of the distributor, depending on the design and filtration characteristics of the «soil-drain» system, are presented. Graph that shows the dependence of the variation in the flow rate distribution unevenness along the length of the drainage pipe at various ​​hydraulic conductivity values of the surrounding soil is important for understanding the drainage pipelines particularity. The necessity to take into account the nature of the flow rate connection unevenness along the length for obtaining reliable results for real drainage pipelines calculation is demonstrated.

The intensive development of information and control technologies, as well as their integration into a single information space, leads to an increase in the role of such technologies in the processes of control of troops (forces) and weapons, including high-precision ones. At the same time, the electronic material base of the information infrastructure created within the concept of network-centric warfare is potentially vulnerable to electronic warfare. In this article, the authors analyze the approaches to the impact of electronic warfare on network-centric control systems. In the course of the study, the authors solved the following interrelated tasks: identified information restrictions on the implementation of the network-centric war concept; the prospects for the development of electronic warfare systems that are focused on disruption of the operation of network-centric systems of military control and the prospective scientific and methodological approaches to substantiate the methods of radio-electronic impact on network-centric control systems. In the course of this research, the authors used the basic principles of electronic warfare theory, signal theory, communication theory, queuing systems and classical methods of scientific cognition – analysis and synthesis. According to the results of the study, the following conclusions can be drawn: perspective directions for the development of radio-electronic impact, oriented on the transport layer of communication networks, can be implemented as complexes of territorially distributed means of electronic control, implementing fundamentally new methods of suppression, and special software and bookmarks software (viruses) that are introduced into the telecommunications network equipment. It should be noted that the use of all the above radio-electronic effects is advisable only against packet networks with advanced topology. The use of such impacts against networks with tree topology is pointless since there is a possibility of attaining the suppression effect by“classical” channel suppression.

Subject and Purpose. One of the ways to gain in the efficiency of the hyperthermia technique is through the synthesis of new magnetic nanomaterials offering high coercive force without affecting biocompatibility. A proven technology is the doping of biocompatible materials, such as Fe3O4, with atoms of highly coercive substances, such as Co atoms. Despite it has been the theme of much investigation, magnetic state of such nanoparticles is still not completely understood. The present study is devoted to the magnetic and magnetic resonance properties of Fe1–xCoxFe2O4 nanoparticles synthesized by the precipitation from diethylene glycol at two, T = 200 °C and 500 °C, temperatures. The purpose is to study magnetic and magnetic resonance properties of Fe1-xCoxFe2O4 nanoparticles at various concentrations x. Method and Methodology. The magnetometric method and the electron spin resonance method were employed to obtain, correspondingly, magnetic hysteresis loops of magnetic nanoparticles and ferromagnetic resonance (FMR) spectra in the frequency band f = 8…20 GHz at the temperature T = 294 K. Transmission electron microscopy was used for nanoparticle observations. Results. The analysis of the measuring results has shown that among Fe1–xCoxFe2O4 nanoparticle samples with concentrations x = 0.0, 0.5, and 1.0, the total magnetic anisotropy field at x = 0.5 is the largest of the three because its crystalline anisotropy field is the largest compared to x = 0.0 and 1.0. Conclusion. The presented results have advanced our understanding of the fundamental interaction between magnetic Co and Fe atoms inside the crystal lattice of AFe2O4, where A is Co or Fe. The gained knowledge can contribute to the development of magnetically controlled high-frequency filters and frequency selectors.

Pharmacotherapy of diabetes mellitus is an extremely important problem of medicine and pharmacy due to its deficient safety and imperfection in maintaining optimal glycemia, frequent changes of which lead to the development of diabetes angiopathies. Therefore, the optimization of existing treatments with herbal collections is appropriate because of their low toxicity and the complex effect of the number of biologically active substances on the pathogenesis of diabetes and its complications. The aim of the research was to determine the qualitative composition and quantitative content of flavonoids in the herbal antidiabetic collections № 3 and № 4. Materials and methods. The objects of the study were the herbal antidiabetic collection № 3, which consists of folium Urticae, radix Cichorii, fructus Rosae majalis, rhizoma Erytrigiae repens, radix Taraxaci officinale , and the herbal antidiabetic collection № 4, which consists of radix Arctii lappa, rhizoma Erytrigiae repens, styli cum stigmatis Zeae maydis, flores Helichrysi arenarium, fructus Rosae majalis . The qualitative composition and quantitative content of flavonoids were determined by the method of high-performance chromatography using liquid chromatograph Agilent Technologies 1200. Results. It was identified 6 flavonoid and it was established their quantitative content, among which the rutin (0.36 %), neohesperidin (0.31 %), luteolin (0.17 %), quercetin (0.05 %), isoquercetrin 0.04 % and naringenin 0.04 % in the herbal antidiabetic collection № 3. It was identified 4 flavonoid and it was established their quantitative content, among which luteolin (0.42 %), rutin (0.29 %), quercetin (0.63 %) and isoquercetrin (0.63 %) in the herbal antidiabetic collection № 4. Conclusions . For the first time, it was determined the qualitative composition and quantitative content of the main flavonoids in the herbal antidiabetic collections № 3 and № 4 by the method of high-performance liquid chromatography. The results of the study showed that the herbal antidiabetic collection № 3 contains 6 flavonoids with a predominance of rutin and neohesperidin, and the herbal antidiabetic collection № 4 – 4 flavonoids, among which luteolin, rutin, and quercetin predominate. This gives reason to conclude about the antidiabetic activity by the pathogenetic mechanism of influence, which indicates that the feasibility of further study of these collections as promising herbal remedies for the treatment and prevention of diabetes mellitus.

Метою статті є комплексне дослідження зв’язку деонтологічних аспектів професійної діяльності працівників Національної поліції України та базових етичних засад діяльності у сфері забезпечення правопорядку. Методологія. Ключовим методологічним підходом у дослідженні є антропологічний. Системно-структурний підхід надав можливість комплексно розглянути феномен етичної поведінки працівників Національної поліції України. У цьому дослідженні акцентовано на структуруванні та проведенні комплексного аналізу деонтологічних аспектів етичної поведінки поліцейського й особливостей її реалізації у сфері забезпечення правопорядку. Наукова новизна. Вихідне антропологічно-правове та професійно-етичне положення дослідження полягає в тому, що до працівників Національної поліції традиційно висувають суворіші вимоги й обмеження – від умов прийому на роботу до практики реалізації прав людини, адже авторитет державної влади безпосередньо залежить від індивідуальної професіональної компетенції поліцейського. Зміна в стратегії правоохоронної діяльності обов’язково має супроводжуватися відповідним реформуванням системи професійної підготовки правоохоронців. Служба суспільству та забезпечення громадської безпеки передбачають відмову від агресивної моделі правоохоронної практики. Рівень відносин суспільства й силових структур потребує не тільки правильного виконання встановлених правил і процедур у площині закону, а й того, щоб ці дії ґрунтувалися на морально виправданих із погляду суспільства рішеннях. Поліцейський повинен не лише нести відповідальність за прийняті ним рішення, а й добре усвідомлювати моральне підґрунтя цих рішень. З огляду на результати наукових досліджень за проблематикою статті та систематизуючи висновки, було доведено вагоме значення й важливість дотримання морально-етичних норм поведінки й усвідомлення загальнолюдських цінностей працівниками поліції та персоналом, задіяним у сфері забезпечення правопорядку, оскільки це безпосередньо позначається не лише на ефективності службової діяльності, а й на розвитку морально-професійних якостей особистості правоохоронця. Ключові слова: професійна етика; деонтологія; честь; гідність; професійна деформація; моральні норми; Національна поліція України; професійна діяльність; етичні принципи; професійний відбір.

Objective - to study the ability of 2,6-dimethylpyridine-N-oxide to modify the cytogenetic effects in mouse bone marrow cells caused by the pro-oxidant mutagen Dioxidine. The cytogenetic activity and mutagen-modifying effect of the plant growth regulator 2,6-dimethylpyridine-N-oxide (Ivin) were studied by the method of accounting for chromosomal aberrations in the bone marrow cells of CD-1 mice (males) with a single joint exposure with Dioxidine. Ivin was administered single orally in the form of an aqueous solution at doses of 710, 71, and 0.7 mg/kg bw, which corresponds to 1/2, 1/20, 1/2000 of LD50 after intraperitoneally administered of Dioxidine at a dose 100 mg/kg. The animals of the positive control group were treated Dioxidine intraperitoneally at a dose of 100 mg/kg bw. Intact animals (negative control group) were orally administered purified, UV-sterilized, deionized water. It was shown that when combined with Dioxidine, Ivin at doses of 710, 71, and 0,7 mg/kg bw significally reduced the frequency of metaphases chromosome aberrations, relative to positive control by 55,56%, 66,70%, and 74,08% respectively. No multi-aberrant and polyploid cells were observed. In all variants of the experiment, only chromatid-type chromosome aberrations with single fragments were detected in the spectrum of chromosome aberrations. The severity of this effect had an inverse dose dependence: with a decrease in the dose of Ivin, the cytogenetic effects of Dioxidine decreased to a greater extent than with high doses of Ivin. The high antimutagenic effect of Ivin was confirmed, which is expressed to a greater extent when it is combined with Dioxidine than with Cyclophosphamide. These findings may be associated with the genoprotective effect of Ivin, due to the stabilization of membranes and its antioxidant effect.

Мета: шляхом аналізу суспільно-політичних та соціально-економічних трансформаційних процесів на Тернопільщині в 1939–1941 рр. та їх наслідків формувати у студентів-медиків почуття патріотизму, компетентності під час програмного вивчення новітньої історії України. Матеріали і методи. На основі історико-порівняльного та бібліосемантичного методів проведено систематичний аналіз наукових джерел вітчизняних дослідників та істориків діаспори, архівних матеріалів щодо інформації про події передвоєнного періоду на території Тернопільщини. Результати. У запропонованій статті авторами розкрито природу та мотиви нової радянської влади, яка збройно вcтупила на територію Західної України 17 вересня 1939 р. і шляхом насилля запроваджувала свої реформи місцевому населенню. Встановлено, що думки дослідників розходяться в трактуванні визвольного походу Червоної армії на захід та виявлено взаємозв’язок загальнодержавних і регіональних чинників радянізації Тернопільщини. Висновки. Авторами зроблено власний внесок у розкриття мотивів та наслідків діяльності тодішньої радянської влади на території краю.

The purpose of the article is a comprehensive study of the professional deformation of the moral consciousness of employees of the National Police of Ukraine, which is due, first of all, to the fact that the process of professional self-determination and realization in anthropological dimension is not only one of the ways of personal development of a person, but for many – the realization of the meaning of life, whereas the change of moral the consciousness of employees in connection with the peculiarities of their professional activity transform the value orientations of the social subject as a legal person. Methodology. The pivotal methodological approach in the study is anthropological. The system-structural approach allowed to consider comprehensively the phenomenon of professional deformation of the National Police of Ukraine. Relying on research material on specific issues and summarizing the findings, it was noted that the most dangerous consequences are precisely the professional deformation of law enforcement officers, since it directly affects the morale of the individual. Morality in the scientific literature is considered as a complex phenomenon through various forms having a certain structure. First of all, objective standards of morality, which regulate social relations, which are defined differently by different authors, namely: moral requirement, moral law, ideal moral guidelines, higher moral values, moral principles, moral ideals, moral criteria, moral norms, moral rules of behavior, ethical ideas, moral necessity. The scientific novelty of this research stems from the problem of the phenomenon, as well as from the purpose, which is closely related to the proposed approaches, methodology and tasks, which reflect the value basis of the research. The authors say that the most prone to deformation are representatives of the following professions: law enforcement, military, leaders, deputies, officials, social workers, lawyers, educators, physicians, salespeople, psychologists. When it comes to the deformation of the moral consciousness and professional justice of law enforcement officers, most often they refer to the negative phenomena, traits that are formed spontaneously or consciously by some representatives of this professional group contrary to social, state requirements, standards of professional activity and behavior. Naturally, they are hidden, but express a new setting of individual value consciousness and are realized in behavior, actions in the absence of external control. Such guidelines and actions may be of a socially undesirable, inadmissible or dangerous, unlawful nature. This study focuses on structuring and conducting a comprehensive analysis of the factors and factors that lead to the professional deformation of National Police officers, as well as providing recommendations on the results of the work done, with the aim of preventing and preventing professional deformation of law enforcement officers. Conclusions. After analyzing the available information on a number of certain violations and checking statistics on such events, it was concluded that the violations of the law, as a rule, are a result of professional and moral deformation of individual employees of the National Police of Ukraine, lack of effective control mechanism and demand from some leaders, low level of organization of educational work, moral and psychological preparation and training of personnel. In preparation of the program of prevention of professional deformation of employees of the National Police of Ukraine, it is advisable, first of all, to improve the normative and legal bases of the functioning of law enforcement agencies, the order of service of different categories of employees; to envisage amendments to the existing acts, and, secondly, to provide for measures within the existing legal framework with a focus on the grassroots. Keywords: anthropology of law; professional deformation; moral consciousness; National Police of Ukraine; moral standards and principles; professional ethics.

A Correction to this paper has been published: 10.1007/s13253-022-00501-6

Heart failure - severe, common clinical syndrome that is the result of many heart diseases is progressive, significantly reduces the life expectancy of patients and impairs its quality. Leading nosological forms the structure of coronary heart disease for many years, is a myocardial infarction. Growing proportion of elderly in most populations, increased survival after acute myocardial infarction (AMI) resulted in a significant increase in the number of patients with chronic heart failure (CHF). Increased tone of the sympathetic division precedes the development of chronic cerebral ischemia and, therefore, may complicate the course of disease in the presence of chronic heart failure.

У статті представлені методи побудови та впровадження автоматизованої електронної системи збору та аналізу інформації про різні фізичні параметри навколишнього середовища в умовах тривалих безперервних вимірювань. Система розроблена на базі мікропроцесорних пристроїв з використанням бездротових технологій з реалізацією алгоритму EKF SLAM для локалізації місць з нерівномірним розподілом параметрів навколишнього середовища для мінімізації забруднення чистих приміщень. Крім того, вона може передавати сигнали через комп'ютер оператора до елементів управління приміщенням. Таким чином, здійснюється мінімізація факторів зовнішнього середовища для фізичних зразків та високоточного обладнання, тим самим продовжуючи термін її служби. The article presents methods for constructing and implementing an automated electronic system for collecting and analyzing information about various physical parameters of the environment under conditions of long-term continuous measurements. The system is based on microprocessor devices using wireless technologies with the implementation of the EKF SLAM algorithm for localizing places with an uneven distribution of environmental parameters to minimize pollution of cleanrooms. Also, it can then transmit signals through the operator's computer to the control elements of the room. Thus, the minimization of environmental factors for physical diseases and high-precision equipment is carried out, thereby extending its service life.

Objective - to study the ability of N-oxide-2,6-dimethylpyridine to modify the cytogenetic effects in mouse bone marrow cells caused by an alkylating antitumor cytostatic cyclophosphamide.; The cytogenetic activity and mutagen-modifying effect of the plant growth regulator N-oxide-2,6-dimethylpyridine (Ivin) were studied by the method of accounting for chromosomal aberrations in the bone marrow cells of CD-1 mice (males) with a single joint exposure to cyclophosphamide. In the first variant of the research, Ivin was administered single orally in the form of an aqueous solution at doses of 710, 71, 7.1, 0.7, and 0.07 mg/kg bw, which corresponds to 1/2, 1/20, 1/200, 1/2000 and 1/20000 from LD50. In the second variant - Ivin was administered together with Cyclophosphamide (Ivin - in the same way as in the first research variant, cyclophosphamide was administered intraperitoneally at a dose of 40 mg/kg bw the same as the positive control group). Intact animals (negative control group) were orally administered purified, UV-sterilized, deionized water.; It was shown that with isolated administration of Ivin in the studied doses did not show mutagenic activity. When combined with Cyclophosphamide, Ivin at a dose of 710 mg/kg bw did not induce the frequency of metaphases with chromosome aberrations and at a dose of 71 mg/kg bw reduced the frequency of metaphases with chromosome aberrations by 1.8 times in comparison with the positive control. In both of these dose groups, Ivin reduced the number of chromatid-type aberrations and polyploid cells but increased the number of multi-aberrant cells. This is probably due to the additional chemical load and physicochemical state of the Ivin molecule. When combined with Cyclophosphamide, Ivin at low dose levels (7.1, 0.7 and 0.07 mg/kg bw) significantly reduced the frequency of metaphases with chromosome aberrations (by 55.7%, 62.9% и 72.9%, respectively), the amount of chromatid-type aberrations, polyploid, and multi-aberrant cells. This may be due to the gene protective effect of Ivin, because of the stabilization of membranes and its antioxidant effect.

Ukrainian breeders evolved and have been evolving meat breeds but at the same time in the nearest future the main part of beef will be produced in dairy cattle- breeding as a by-product of milk production. The aim of the research was to study the productive and technological qualities of the mixed breeds of cattle produced from crossing of the cows of the Ukrainian Red dairy breed with the bulls of meat breeds: Aberdin Angus, Ukrainian, Volynian and the Southern breed of Znamensky type. Scientific and production experiment was carried out on the research farm “Stepove” Kirovograd region, at the research agricultural station and 64 bulls of different breed combinations and 16 purebred bulls of Ukrainian Red dairy breed were taken for the experiment. The bulls under investigation were kept in accordance with the technology and the rules adopted on the farm, they were fed by the same diet. The ration of the bulls was balanced by the detailed standards (Kalashnikov, 1985) that provided the daily weight gains at the level of 900 g and more. The composition of the feeds was changed depending on the season of the year and the period of animal growing. The analysis of the change of the live weight of the young cattle kept in the similar technological conditions has shown that the animals of different genotypes had different dynamics of growth. One of the reasons for that was the fact that they had had different live weights at birth. The calves of Aberdin Angus mixed breed had the lowest live weight at birth (Р< 0,05), due to their high energy of growth they surpassed the animals of the control group in the live weight. They had the highest relative rate of growth from birth to 18-month-old age. The mixed bulls produced from the bull of the Ukrainian Red meat breed had the highest absolute weight gain (554,5 kg) and, respectively, the highest daily weight gain (1014 g). The data of the results of the slaughter proved high meat productivity of bulls in all the groups. All groups of mixed bulls had higher slaughtering output by 1,4-3,9% as compared to the bulls of the control group. As for the level of profitability of beef production even without donation the bulls produced from crossing the cows of Ukrainian Red dairy breed with the bulls of the Ukrainian meat breed had the best results (51,3%), the mixed bulls produced from crossing with Aberdin Angus breed had a little lower values (50,4%) than with Volynian meat breed (47,5%) and Znamensky type of the Southern meat breed (46,0%).

У статті відображено вплив інвестиційних процесів на економічний розвиток України. Розглянуто сутність та формування «загальної податкової ставки» в Україні, податкове навантаження та фіскальну політику держави. Проведено аналіз стану української економіки у світовому рейтингу. Виділено переваги залучення інвестиційних ресурсів та надання пропозицій щодо поліпшення інвестиційного клімату в Україні.

The application of adaptive drives in working units of various technological and mobile machines is considered. The results of theoretical and experimental research have proved the effectiveness of their use for improving the dynamic characteristics of machines, reducing unproductive power losses during their operation.

The article spotlights decisive factors of the Syrian-Turkish interstate relations evolution after the end of the Cold War, special attention was given to clarify place of the water and the Kurdish problems in the relations between the two countries. After World War I in Syria and many other Arab states the Republic of Turkey was seen primarily as a legal successor of the Ottoman Empire that for several centuries colonized these countries and prevented their civilizational development. With the collapse of the bipolar system of international relations between Syria and Turkey broke a serious struggle for influence in the region. An important security problem in the Syrian-Turkish relations was left water, ie the distribution of resources river Euphrates because hydrographic feature of the Middle East is extremely uneven distribution of freshwater. Normalization of bilateral interstate relations delineated only with coming to power in Republic of Turkey the moderate Islamist Justice and Development Party led by Recep Tayyip Erdogan, whose foreign policy aimed at establishing closer ties with the Middle East countries and a visible mediating role in resolving the Arab-Israeli conflict. Immediately after the consolidation of the power vertical Justice and Development Party began to distance itself from Israel in order to establish a more open dialogue with Mashriq states.

Atherosclerotic cardiovascular disease is the leading cause of mortality worldwide. Evidence suggests that the risk of atherosclerosis complications associated not only with local changes within atherosclerotic plaque (such as the state necrotic core or fibrous cap), but also with the state of blood or systemic factors. Circulating levels of cytokines, prothrombotic factors or acute phase reactants may play a role in the occurrence of acute stroke in the presence of affected vessels, even in the absence of stenosis. For example, increased serum biomarkers such as C-reactive protein, cytokines - predict the progression of atherosclerosis and risk of stroke. Stroke, may be caused by atherosclerosis of large arteries supplying the brain, or it may affect smaller branches inside the skull.

Проаналізовано результати обстеження та лікування 294 дітей із доброякісними пухлинами та кістами межистіння. Виділено два різновиди клінічного перебігу: асимптомний і типовий. Типовий перебіг проявлявся синдромом медіастинальної компресії. За умов переважного компресування органів або структур відповідної системи, виділено п’ять основних органоспецифічних симптомокомплексів: респіраторний, гемодинамічний, дисфагічний, нейрогенний, остеогенний. Провідним органоспецифічним симптомокомплексом був респіраторний. У патогенезі останнього, в період обмеженої органоспецифічної симптоматики, визначено ланку «місцевої іммобілізації», відповідно до локалізації утвору, як перший ступінь компресії повітряпровідних шляхів та пусковий механізм респіраторного симптомокомплексу. Провідними методами діагностики утворів межистіння є променеві. Лікування доброякісних утворів межистіння – оперативне.

Optical near-field nano-polishing of the surface of a quartz substrate using dipole-dipole interaction of atomic chlorine with quartz particles is studied. A method to obtain atomic chlorine by the local photodissociation of the hypochlorite anion by the optical near-field of the quartz substrate nano-inhomogeneities is proposed. The polarization of chlorine atoms and quartz particles by means of an evanescent wave, which is generated on the substrate surface, is investigated. A method is proposed to obtain the most optimal orientation of the dipoles of atomic chlorine and quartz particles, using the features of the optical near-field, to maximally efficiently destroy the quartz substrate nano-inhomogeneities. The surface roughness of the quartz substrate was significantly reduced by using the proposed nano-polishing method for 20 minutes: $R_{\mathrm{a}}$ from 56.33 nm to 27.33 nm (by 51.48%), $R_{\mathrm{z}}$ from 247.51 nm to 138.51 nm (by 44.04%) and $R_{\max}$ from 317.22 nm to 156.22 nm (by 50.75%). The near-field nano-localization of photochemical etching processes theoretically has no dimensional limitations up to the size of single atoms. The use of an optical near field (including an evanescent wave) allows the nano-localization of chemical reactions. This method can be used in nanochemistry and nanotechnology.