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Today, 89% of all parasitic diseases are caused by helminthiasis. The annual morbidityof helminthiasis in Ukraine is 1333 cases per 100 thousand population. Their influenceleads to the development of multiavitaminosis with decreased appetite, body weight andresistance to adverse factors and metabolic disorders. Therefore, the issues of effectiveprevention and treatment are extremely relevant.Objective - to conduct a marketing analysis of the range of antiparasitic phytodrugsavailable on the Ukrainian pharmaceutical market and to determine the prospects fortheir further use in medicine.Material and methods. The analysis of the range of drugs, dietary supplements andmedicinal plant raw materials with anthelmintic action available on the pharmaceuticalmarket of Ukraine was conductedResults. 102 trade names in various dosage forms were identified, according to theanalysis of the range of drugs, dietary supplements and medicinal plant raw materialswith anthelmintic action available on the pharmaceutical market of Ukraine. It has beenfound that the range of drugs is mainly represented only by biologically active additives(97.06%). It should be noted that among the drugs there are both one-component dietarysupplements (18.63%) and combined (81.37%). The ratio of shares in the production ofantiparasitic drugs is approximately the same, domestic producers - 48.04% and foreignmanufacturers - 51.96%.Therefore, taking into account the topicality of the parasitic diseases problem, it isadvisable to use phytodrugs because of the action complexity at the expense of thebiologically active substances of plants, the lack of toxicity in contradistinction tosynthetic antiparasitic drugs.Conclusions. The represented phytodrugs and dietary supplements can be used asadditional means for pharmacotherapy improvement of the worm infestations, as well asfor recurrence prevention.

Objective – to consider the method of organization and performance by the students ofthe Pharmacy Faculty of practical tasks when studying flat and round worms – humanparasites in biology classes with the bases of genetics.Brief description of the work. The article analyzes the methodological approaches tothe organization and implementation by students-pharmacists of practical tasks inbiology with the bases of genetics, concerning medical helminthology studied by them.An approximate list and content of tasks of independent educational and research work ofstudents, aimed at the formation of practical skills and competencies necessary for theirfuture professional activity, are adduced.Conclusion. Performing the above tasks of independent educational research in practicalclasses in biology with the bases of genetics, students-pharmacists do not only deepenand consolidate their theoretical knowledge about helminths – human parasites andtheir role in the development of parasitic diseases, but also develop practical skills toidentify them. main representatives, determining the place of helminthiasis among otherinvasive human diseases, measures for prevention of relevant diseases. In the processof performing practical tasks in medical helminthology by students-pharmacists, theformation of integral, general and special competencies is ensured in them.

Toxocariasis is usually transmitted by ingesting invasive eggs from the soil, howeverrecent reports indicate that the pathogen can also be transmitted by ingesting raw meatfrom infected chicken, rabbit or lamb. Also, the infection of infants through mother's milkand transplacental is very relevant now.Objective. The aim of the study was to determine the state of clinical and laboratoryparameters in the case of Toxocara canis invasion in infants, to optimize the principlesof diagnosis and prevention of toxocariasis in infants based on the study of the epidemiological, clinical and immunological characteristics of the course of the invasion,assessment of the severity of the general condition and natural resistance of the organism.Material and methods. 38 children (24 boys and 14 girls) aged from 6 to 12 monthswere examined. During clinical and laboratory examination of children, clinical andepidemiological, biochemical, serological, immunological research methods were used.ELISA samples with an antibody titer of 1:800 and higher were considered diagnosticallypositive. In addition to the history of life and illness, much attention was paid to theepidemiological, allergic and obstetric history.Results. To analyze the frequency and nature of clinical and laboratory manifestations,their correlation with the results of serological studies, all sick children were divided into3 groups. The first group consisted of 16 children with a seropositive reaction and a scoreof 28.94±1.2 (from 24.5 to 34). The second group included 17 children with a seronegativereaction and a score of 6.91±3.1 (from 2 to 11.5). The third group consisted of 5 childrenwith a seronegative reaction and a score of 19.5±1.4 (from 15.5 to 23). An analysis ofthe results obtained and a comparative assessment of the frequency of manifestation ofthe revealed disorders in each group made it possible to establish that such clinical andlaboratory indicators as hypergammaglobulinemia, hypoalbuminemia and leukocytosiswere significantly more often (5, 8 and more times) observed in children of group 1.Anemia and enlargement of the liver were equally common in all three groups. There wereno significant differences in the frequency of manifestations in children of groups 1 and 3of such clinical and laboratory parameters as recurrent fever, increased ESR, pulmonarysyndrome, radiological signs of lung damage, abdominal syndrome, neurologicaldisorders, lymphadenopathy, eosinophilia, which were significantly less common or werenot detected in group 2 children in general. As for eosinophils in the blood, at the samefrequency, more stable and high eosinophilia was observed in children with toxocariasis(from 20 to 42%) than with food allergies (11-20%). Similar results were obtained whenevaluating clinical and laboratory parameters in points (by Glikman). In all children withtoxocariasis and food allergy, the sum of clinical and laboratory parameters exceeded 12scores and significantly differed from the results of group 2. At the same time, the sum ofpoints in children of group 1 was 28.94±3.1 (from 24.5 to 34), and in children of group3 it was 19.5±2.3 (from 19.5 to 23). As for skin manifestations, they were more commonwith food allergies than with toxocariasis.Conclusions. In infants, invasion by toxocara larvae is possible. In addition to theusual routes of infection, there is the possibility of transplacental invasion from amother infected with toxocariasis. For the timely detection of toxocariasis, infants withhypergammaglobulinemia, hypoalbuminemia, leukocytosis with persistent eosinophiliaabove 20% and a score above 20 (according to Glikman) should be examined fortoxocariasis. To clarify the diagnosis and exclude toxocariasis in both the child andmother, it is necessary to conduct serological tests for toxocariasis.

In Ukraine, about 100,000 cases of geohelminthiasis are registered annually, 80%of which are children under 17 years of age. Symptoms of helminthiasis are mild orcompletely absent, but harmful to the body, however, infection of the child's body isespecially dangerous.Objective - to conduct a marketing study of drugs, used for treatment, and identify themain problems of this pathology prevention.Material and methods. A marketing research and analysis of the trade names’ market,analysis of 52 medical records of inpatients and outpatients (children aged 12 to 17years) for worm infestations and medical records of medical institutions in Chernivtsihave been carried out.Results. At the first stage of the research, a statistical study of invasive diseases state wasconducted and the main risk factors for infection were identified. We studied the rangeof antiparasitic drugs available on the domestic pharmaceutical market. Albendazole ismost often used as an active anthelmintic agent, 75% of which are domestic and 25% ofimported production. Preparations with the active substance pyrantel pamoate accountfor 42.8% of domestic production, all others are imported. According to the results of theprocessed medical records of patients several of the most common treatment regimens,which include anthelmintic therapy, the use of enterosorbents and the appointment ofa 5-day course prescription of H1-histamine receptor blockers were chosen. Havinganalyzed the average cost of the day treatment of nematode infestations, we came to theconclusion that the most available complex of group II drugs, the main antihelmintic drugis Zentel.One of the measures to prevent helminthiasis is the use of phytopreparations anddietary supplements based on medicinal plant materials, which, unlike chemicals, arecharacterized by milder properties and less toxicity, the ability not only to affect thepathogen directly, but also to restore the functional state of the organs and systemsaffected by worm infestation.Conclusions. From the offered schemes of pharmacotherapy the most accessible is theuse of a complex which structure includes Сarbowhite, Rolinoz, Zentel. It is promising tostudy the use of phytomedicines both during medical therapy and for prevention.

The problem of parasitosis is quite pressing today, as the morbidity remains one of the most common in the world. According to the statistics, every third inhabitant of the planet is infected with one or another helminth, often 2-3 or even more of their species. In Ukraine 400-600 thousand patients with helminthiasis are registered each year, which is 53% of all infectious diseases, 80% of the identified patients are children. However, based on sales of anthelmintic drugs, the number of infected parasites can be several times higher. Objective - to optimize the reduction of helminthiasis treatment cost by conducting a pharmacoeconomic analysis of the anthelmintic drugs use. Material and methods. In order to monitor the state of the pharmaceutical market of antiparasitic drugs, we analyzed 83 medical records of inpatients (children aged 1 to 14 years) for worm infestations and medical records of medical institutions in Chernivtsi. Results. According to the results of pharmacoeconomic analysis "cost minimization", it was found that in the age category of 1-2 years while using a suspension of «Vormil» and «Zentel», there was no significant difference in the price of drugs for the treatment course. «Angelmex» (45%), «Vormil» (35%) and «Zentel» (15%) are used in the age group of 2-6 years. In the age group of 6-12 years, the choice of drug depends mostly on the dosage form, in 20% of cases more often they choose chewable tablets, due to the more comfortable way of use, regardless of the drug’s price. In the second stage of the research, a pharmacoeconomic analysis of the dietary supplements use for the helminthiasis prevention was performed. The cheapest for the treatment course was «Phytoglistocide» in the form of capsules (126,83 UAH) and syrup (275,88 UAH), and the most expensive - «Vormil Phyto» in the form of syrup (444,6 UAH). Conclusions. According to the results of the conducted researches it has been established that enterobiasis remains the most widespread in the Chernivtsi region area. Albendazole group agents in the form of tablets and suspensions are most commonly used in these helminthiasis treatment. The drugs of choice are «Algelmex», «Vormil», «Zentel», the choice of which depends on the age category.

Today, the parasitic diseases are the most common in the world and occupy one of the first places in terms of prevalence and economic losses. The reasons for this situation, according to experts, are low-quality epidemiologically dangerous water and low compliance with sanitary and hygienic standards. The problem of prevention and treatment remains relevant for almost all countries, including Ukraine. Objective - to conduct a marketing analysis of the range of the domestic pharmaceutical market of antiparasitic drugs. Material and methods. A marketing analysis was conducted using structural, logical, graphical, systematic and content analysis of data from the State Register of Drugs. Results. The first stage of the research was to study the range of antiparasitic drugs represented on the pharmaceutical market of Ukraine. It has been determined that in the pharmaceutical market, according to the State Register of Drugs of Ukraine, 22 names of anthelmintic drugs are registered. It has been established that the drugs, supplied to the domestic pharmaceutical market from every corner of the world, are 12 trade names, among which the leading positions in terms of supply are India and France (23% respectively). Antiparasitic drugs are presented in 3 dosage forms, among which the largest share are tablets - 65.2%, oral suspensions - 30.4%, the least in the pharmaceutical market are phytodrugs with antihelmintic activity (4.6%). The analysis of the registered antihelmintic drugs has shown that 95.6% of the study drugs are available by prescription. Conclusions. It has been found that the largest share of drugs are benzimidazole derivatives, which account for 47.8% of the total range of the studied drugs, the most common among anthelmintic drugs are dosage forms in tablets (65.2%).

Enormous pollution of the environment exacerbates the parasitic situation, which stipulates its urgency. Objective – to generalize medical and biological problems of helminthiasis and to determine the main directions of the disease prevention and treatment. The problem of helminthiasis spread, mechanisms of parasite infection were considered,information concerning parasite development cycles and life expectancy of helminths in the human body were generalized, the impact on the human body and changes in organs and tissues that occur in helminthiasis were determined, peculiarity of the clinical manifestations and disease diagnosis were indicated at, specific features of preventive measures with enterobiosis and the main causes of high incidence of helminthiasis were determined. Conclusion. Development and implementation of a modern strategy of parasitic control, the use of the latest detection methods, timely diagnosis and treatment of patients with helminthiasis and prevention of helminthiasis are the main tasks to ensure the safety of the human life.

The work of Medical Biology Department of Bukovinian State Medical University over 70 years has been analysed. General directions of teaching, researching and educational work at the junction of two centuries have been characterised.