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Under the conditions of sanctions, the development of petrochemical production in Under the conditions of sanctions, petrochemical production development in Russia is especially important both from the point of view of high-grade products growth with increased margins and the need to increase demand for hydrocarbons within the country with a decrease in export supplies. The purpose of the study is to analyze the existing and identify the main possible incentive measures of state support to enhance investment activities in modernization and creation of new production facilities of Russian petrochemical complex. Methods such as generalization, analysis and synthesis, classification and modeling were used in the work. As a study result, main problems and challenges facing the industry have been identified. Priority areas of oil and gas companies’ activity necessary for petrochemistry accelerated development, positive examples of cooperation in the field of gas processing and gas chemistry, as well as industrial clusters creation have been presented. Project financing mechanisms of the state corporation VEB.RF have been analyzed. The need to attract competent specialized Russian EPC contractors from the register recommended by VEB.RF for implementing projects in the field of petrochemistry has been explained. Using the example of methanol production and its use as a raw material for high-grade products creation, importance of long-term contractual relations between the state and business, such as agreements on protection and promotion of capital investments and special investment contracts, has been shown. The need to ensure continuity of state support measures at all stages of creating and implementing technologies for developing and improving petrochemical products has been formulated.

The article discusses promising areas that contribute to the formation of a closed-cycle economy or, in other words, a circular economy in the Russian fuel and energy complex. The basic principles of the circular economy model aimed at preserving the environment through the transition from linear business models to more closedones and by increasing the efficiency of natural resources use have been outlined. The data on the estimates of the negative impact combustion of associated petroleum gas have been presented, the methods of its rational utilization and further use as raw materials for high-grade products have been analyzed. The petrochemical complex is presented as one of the fundamental elements of the circular economy. The advantages of using biogas as a supplement and alternative to fossil natural gas when moving towards a circular economy have been substantiated. The importance of implementing biogas projects in Russia in modern conditions has been emphasized. Factors’ number of constraining the development pace of the circular economy in the fuel and energy complex sectors have been identified. The key support measures and stimulation of companies by the state have been outlined.

The implementation of the programme for modernisation of Russian oil refineries, launched in 2011, has already significantly increased the depth of oil refining and the quality of petroleum products. It has had a positive effect on reducing the country’s dependence on crude oil exports and has made it possible to obtain a significant positive environmental effect. However, at the same time, there has been a decrease in marginality. At the present stage, the main problems of the Russian oil refining, which affect, among other things, the implementation of modernisation projects, are associated with a ban on the supply of equipment and software for oil refining, the imposition of an embargo and a price ceiling for oil products. The article analyses the results of the implementation of the modernisation programme in terms of the impact on economic and environmental performance of oil refineries and the impact of sanction restrictions on the further modernisation of enterprises. It also considers possible ways to solve problems through the development and implementation of modern production technologies in combination with digital solutions.

Due to the fact that the sanctions regime of Western countries is aimed at destroying Russia’s foreign trade relations and restraining the economic development of Russia, the article considers the increased importance of the main aspects of energy stability and presents a state assessment of Russian Federation energy security in conjunction with energy availability and environmental sustainability using the energy trilemma index. A number of urgent problems that have arisen in the fuel and energy complex as a result of sanctions have been identified. The general scheme of fuel and energy complex transformation is presented and possible ways of solving problems are given. The necessity of carrying out a set of measures for the transformation of the fuel and energy complex, including short- and medium-term measures necessary to ensure the state of energy security and sustainable economic development of Russia is substantiated.

Against the background of the decline structure of hydrocarbon reserves in Russia, the maintenance of a stable level of production and enhanced oil recovery at mature fields is associated with the introduction of technologies of the fourth industrial revolution (Industry 4.0). The real and possible impact of digitalization on the oil recovery factor and impact of the technological solutions on the development hard-to-recover reserves have been сonsidered in the article. Special attention has been paid to the transition to intellectual methods of management, within the framework of digitalization, which ensure the effective management for all company’s processes, provide objective and transparent information for making accurate and operational management decisions. To ensure a significant effect from the digital transformation of the industry, it is necessary to create favorable investment conditions, including government regulation and stimulation.

Transgenic Drosophila melanogaster lines modeling the main neuromorphological markers of Alzheimer's disease were used to study the neuroprotective properties of nicotinic acid. Thirty days old flies treated with nicotinic acid showed better survival rate and reduced neurodegeneration.