217 results on '"O. A. Yakovleva"'
Search Results
2. Inheritance of juvenile resistance to powdery mildew in barley accessions from Ethiopia
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R. A. Abdullaev, O. V. Yakovleva, and T. V. Lebedeva
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barley lines ,allele ,genotype ,resistance genes ,pathogen ,blumeria graminis f. sp. hordei ,Biotechnology ,TP248.13-248.65 ,Botany ,QK1-989 - Abstract
Background. Barley (Hordeum vulgare L.) is one of the key food crops, ranking fourth in the world in terms of sown area and production among cereals. Often, one of the main factors that reduces yield and product quality is the spread of fungal pathogens in commercial crops. Powdery mildew (causative agent: Blumeria graminis (DC.) Golovin ex Speer f. sp. hordei Marchal) is considered one of the most common and harmful among barley diseases. Plant resistance to B. graminis limits the spread of the disease, and the development of resistant cultivars prevents a decrease in plant productivity. The specificity of the host–pathogen relationship and the loss of efficiency in many genes determine the need for a continuous study of previously unexplored local barley forms and a search for new, most effective resistance genes.Materials and methods. The genetic control of juvenile resistance to B. graminis was studied in 14 accessions of spring barley from the Ethiopian (Abyssinian) center of crop origin. The natural population of the pathogen served as infectious material for infecting barley. The intensity and nature of sporulation as well as the qualitative reactions of plant tissues in response to the penetration of the fungus (necrosis and chlorosis) were accepted as indicators of resistance in the accessions. Powdery mildew resistance was assessed under laboratory and field conditions. The genetic control of the resistance trait was studied using the method of hybridological analysis followed by statistical processing.Results and conclusions. Barleys from the Ethiopian center of morphogenesis are characterized by great genetic diversity. Studying the inheritance of juvenile resistance to powdery mildew made it possible to ascertain the monogenic control of the trait in all studied forms. Ten barley accessions with one effective recessive resistance allele and four with the dominant control of the trait may be recommended for immunity-targeted breeding.
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- 2024
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3. Genetic diversity of wild barley (Hordeum spontaneum K. Koch) in the context of resistance to toxic aluminum ions
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O. V. Yakovleva
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wild barley ,aluminum ,ionic stress ,aluminum resistance ,Biotechnology ,TP248.13-248.65 ,Botany ,QK1-989 - Abstract
Background. The problem of resistance to aluminum toxicity of soils is very relevant for the cultivated type of barley. The area of acidic soils in Russia is about forty percent of the total area of arable land, so the toxicity of aluminum is one of the main factors that reduce the yield of barley. The study of wild relatives of the main crops, including barley, is of considerable interest for the development of stress-resistant cultivars. Wild barley Hordeum spontaneum K. Koch has biological characteristics similar to the cultivated H. vulgare L., grows in various ecogeographic zones, and is well adapted to local soil and climate conditions. All this makes it possible to use it as a new donor of source material for breeding high-yielding cultivars adapted to certain environmental conditions. The objective of this work was to search for H. spontaneum genotypes highly resistant to ionic (Al3+) toxicity.Materials and methods. One hundred accessions of H. spontaneum from the collection of the N.I. Vavilov All-Russian Institute of Plant Genetic Resources (VIR) were examined. The resistance of barley accessions to toxic aluminum ions was studied at the early stages of plant development by the root test method (185 mcМ Al3+, pH 4.0) with the calculation of root and sprout length indices.Results and conclusions. The studied fragment of the wild barley collection demonstrated broad genetic diversity in terms of resistance to phytotoxic aluminum ions. Laboratory assessment allowed us to identify barley genotypes differing in the reaction of their roots and sprouts at the early phases of ontogenesis. The identified genotypes with a high level of resistance to ion stress can be used as a valuable source of genetic material to improve existing cultivars and develop new ones by introgression of foreign resistance genes.
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- 2023
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4. New hulless oat variety ‘Azil’
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A. D. Kabashov, A. S. Kolupaeva, V. G. Zakharov, N. M. Vlasenko, O. G. Mishenkina, O. D. Yakovleva, Ya. G. Leybovich, Z. V. Filonenko, L. G. Razumovskaya, and P. M. Polityko
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hulless oats ,variety ,productivity ,grain quality ,resistance ,mycotoxins ,Agriculture (General) ,S1-972 - Abstract
The current paper has presented the study results of the new hulless oat variety ‘Azil’, which was developed by the method of individual-family selection from the hybrid population ‘Krestyansky local × ZALP’. The purpose of the current study was to identify economically valuable traits, physico-biochemical indicators of the grain of the new hulless oat variety ‘Azil’. According to the length of the vegetation period, ‘Azil’ is classified as a middle maturing variety. In the State Variety Testing, the realized productivity of the variety ‘Azil’ was 5.36 t/ha. During the study, there has been found that with intensive and high-intensity cultivation in compliance with the technological methods of protection against diseases, weeds and pests, the productivity of the variety ‘Azil’ improved in relation to the basic technology from 0.75 to 1.42 t/ha (or on 12 and 23 %, respectively). The estimation of groat properties has revealed a larger protein and oil percentage in grain of the new variety than that of the hulled and hulless standard varieties ‘Yakov’ and ‘Vyatsky’ (2.2 and 0.2 % of protein; 1.3 and 0.5 % of oil) . There has been identified high loose smut resistance of the variety ‘Azil’ (up to 6.4 % damage) on artificial and natural backgrounds. There has been established a fungi composition and mycotoxins’ content in grain of the standard oat varieties ‘Yakov’ and ‘Vyatsky’, as well as 13 hulless breeding lines of the Federal Research Center “Nemchinovka”. The variety ‘Azil’ has demonstrated an increased resistance to the accumulation of T-2 toxin. Using biochemical methods there has been found heterogeneity of the new variety, consisting of two biotypes. When conducting primary seed production, there has been recommended to use the method of individual-family selection with a double estimation of the progeny and maintaining spatial isolation with other hulless oats.
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- 2022
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5. Training of specialists of Health Technology Assessment: experience of foreign countries
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N. A. Bilousova, O. V. Getalo, and O. S. Yakovleva
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health technology assessment ,specialists ,postgraduate medical education ,vocational education ,non-formal education ,short-program ,trainings ,Therapeutics. Pharmacology ,RM1-950 ,Pharmacy and materia medica ,RS1-441 - Abstract
According to the main values of international HTA organizations regarding the development of scientific potential and training of specialists in this field and taking into account the conditions of implementation of medical technology assessment in Ukraine, the scientific interest includes the professional training of HTA users and developers. In this regard, the need of studying the foreign experience and best practices in the use of various curricula, the introduction of forms, methods and technologies is actualized. The author pays special attention to the issue of training these specialists in the system of postgraduate education. The aim of the article was to analyze the use of modern forms, methods and technologies in vocational education and training of specialists in the assessment of medical technologies. Materials and methods of the research were strategic programs of EU and Ukraine development, normative and legal documents regulating the implementation of HTA, legislative acts on education development in Ukraine, publications in scientometric databases of Scopus, Web of Science and others. Research methods used: systematic search of information using search engines, databases and websites by keywords; content analysis of documents; situational and comparative analysis; generalization; prognostication. According to the results of the analysis of scientific works, the study of international experience revealed that in foreign countries all types of education are used to train specialists in HTA: formal, non-formal, informal. It was found out that the most common forms of obtaining this specialty in the system of formal education are bachelor’s degree, master’s degree, training of doctors of philosophy. At the same time, for the training of such specialists in the middle-income countries, the programs of various duration in the system of non-formal education are used the most often. Among them: courses, trainings, seminars, internships, apprenticeships, mentoring, etc. Certification upon completion of the training is required. Based on the foreign experience and the analysis of scientific literature, the feasibility of creating and implementing various programs (long-term and short-term, in-service and non-in-service, distance, extramural, full-time, etc.) of the HTA specialists’ training in non-formal education completion of training was proved.
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- 2022
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6. Pedagogical management in the digital educational environment: Theoretical aspect
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S. S. Kulikova and O. V. Yakovleva
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цифровая образовательная среда ,педагогическое управление ,субъекты образования ,цифровые инструменты ,цифровые образовательные ресурсы ,цифровая образовательная коммуникация ,цифровые следы ,модель педагогического управления ,молодые педагоги ,Education - Abstract
Introduction. The digital educational environment is becoming not only a challenge of the new time, but also an important condition, a means of training a specialist of the new formation for the digital society. In the digital environment, a teacher will have to learn how to organise, accompany and support the educational activities of students, build network interaction, exercise control and assessment, and create flexible personalised mastering of content. For this, it is important to understand the new nature and features of the implementation of pedagogical management in the context of the global digitalisation process.Aim. The aim of the paper is to comprehend the systemic changes associated with pedagogical management in the digital educational environment, to study the new content of the structural components of pedagogical management.Methodology and research methods. The present research was carried out in reliance on the system-activity, subject-personal and environmental approaches. Theoretical and empirical research methods were used. The online survey method formed the basis of the research. The respondents were young practice teachers studying for a master degree in the direction of “Pedagogical Education”. They begin their professional activities at the stage of the formation of a digital society; they will have to implement blended (distance, digital) learning. The authors applied the methods of comparative and contrastive analysis (comparison of the nature of management in a classical (classroom) and digital environment), synthesis and systematisation of data, modelling. Additionally, the methods of statistical analysis were used.Results. The necessity of a systematic understanding of pedagogical management in the context of digitalisation was substantiated. The essence of the concept of “pedagogical management in digital educational environment” was clarified. The features and nature of pedagogical management in digital educational environment were determined, its structural components were highlighted: motivational-target, information-content, organisational-activity and control-evaluative. The vectors of strengthening the professional training of specialists in the field of education were determined.Scientific novelty. The novelty of the research lies in the systemic understanding of the category of pedagogical management in the new digital conditions; in the system-functional description of the digital educational environment management model. It manifests itself in the possibility of revising the professional training programme for future teachers in the context of the digital transformation of the educational process, as well as building innovative educational practices at different levels of education, taking into account the new model of pedagogical management in digital educational environment.Practical significance. It is advisable to use the results of the study to improve the quality of professional training of teachers in digital and blended learning, improve programmes and courses of advanced training, to increase the efficiency of autonomous educational and cognitive activities, implemented with digital tools and technologies, at different levels of education. The material of the article can be useful for specialists studying the issues of pedagogical management in vocational education.
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- 2022
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7. Aluminum resistance of malting barley
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O. V. Yakovleva
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hordeum vulgare l. ,toxic aluminum ions ,drought resistance ,aluminum toxicity ,Biotechnology ,TP248.13-248.65 ,Botany ,QK1-989 - Abstract
Background. Barley is the second cereal crop in Russia in terms of its importance and production volume. It is used for food, feed, and industrial purposes. The production of malting barley in Russia exceeds 1.5 million tons; each year the area under this crop increases by 10–15%, reaching 600,000– 800,000 hectares. Barleys suitable for brewing must have certain physicochemical and technological properties. The main requirements for raw materials are presented in GOST 5060-86 (state standard for malting barley). An important condition for obtaining sustainable harvests is the development and utilization of cultivars resistant to a set of edaphic stressors. The purpose of this work was searching for resistant cultivars for use in targeted breeding.Materials and methods. The material for the study included 161 spring barley cultivars for brewing from the collection of plant genetic resources held by VIR. The laboratory assessment of aluminum tolerance in barley accessions was carried out at the initial phases of plant growth and development, using the method of calculating root and shoot length indices. The tested malting barley was classified into five resistance groups.Results and conclusions. Cultivars resistant to Al3+ ions were identified among different ecogeographic groups of malting barleys. The trait had a wide range of variability in terms of both the root length index (0.17–0.95) and shoot length index (0.47–0.99). Accessions with high resistance to ionic (Al3+) stress can be used in barley breeding targeted at the development of high-yielding malting cultivars most adapted to harmful environmental factors.
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- 2021
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8. Mythology of Parkinson’s disease: from levodopa phobia to dopamine agonist phobia
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O. S. Levin, A. Sh. Chimagomedova, and O. V. Yakovleva
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parkinson’s disease ,levodopa ,levodopa phobia ,dopamine agonists ,dopamine agonists phobia ,Medicine - Abstract
Any common disease (including Parkinson’s disease) is inevitably overgrown with myths. As a result, not scientifically grounded approaches based on the principles of evidence-based medicine, but irrational ideas, especially often of a pharmacophobic nature, begin to dominate in primary clinical practice among doctors and patients. In clinical practice, we can often face to a situation when doctors, dogmatically accepting the principle of delayed initiation of levodopa therapy, for a long time try to guide the patient on other antiparkinsonian drugs, despite the obvious ineffectiveness of such therapy and the increasingly growing immobility of the patient. This phenomenon, based on the irrational beliefs of not only doctors, but also patients in the toxicity of levodopa, is commonly referred to as levodopa phobia. Levodopa phobia, along with the emergence of a new generation of dopamine agonists (DAs), whose ability to delay the development of fluctuations and dyskinesias has been proven in a series of placebo-controlled studies, as well as the erroneous interpretation of the withdrawal syndrome of DAs as evidence of their high effectiveness, have led to the widespread use of this class. drugs. However, the use of DA turned out to be associated with an increased risk of such adverse events as daytime sleepiness, leg edema, impulsive-compulsive disorders, and withdrawal syndrome. All this served as the basis for the appearance of “dopamine agonists phobia”, which can lead to unjustifiably early prescription of levodopa and the development of dyskinesias. What is the optimal way for managementof PD patients today? In our opinion, the patient management formula that doctors should adhere to should be as follows: early prescription of dopaminergic drugs (more often DAs or levodopa) is necessary, which provides a quick possible, albeit incomplete, correction of a motor defect, which would be sufficient to preserve the patient’s motor activity, including his professional activity; as the symptoms increase, an escalation of antiparkinsonian therapy with the sequential addition of levodopa (or DAs), MAO B inhibitors, amantadines is necessary.
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- 2020
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9. Resistance of barley cultivars approved for use in Russia to harmful organisms and toxic aluminum ions
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R. A. Abdullaev, B. A. Batasheva, N. V. Alpatieva, M. A. Chumakov, E. E. Radchenko, O. N. Kovaleva, and O. V. Yakovleva
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hordeum vulgare l. ,resistance ,powdery mildew ,leaf rust ,greenbug ,aluminum ,Biotechnology ,TP248.13-248.65 ,Botany ,QK1-989 - Abstract
Background. The most rational way to reduce barley crop losses from diseases, pests and adverse edaphic factors is cultivation of resistant varieties. The specificity of the host– pathogen interactions necessitates a constant search for new donors of resistance for breeding, and phytosanitary monitoring of cultivars.Materials and methods. The research material comprised 248 barley cultivars included in the State Register of Selection Achievements Admitted for Usage in the Russian Federation – 168 were developed domestically, and 80 by foreign breeders. Their resistance to powdery mildew and leaf rust was studied in under laboratory and field conditions. Barley cultivars distinguished for powdery mildew resistance were analyzed using molecular markers. In the laboratory, barley was screened for greenbug resistance. To study the sensitivity to toxic aluminum ions in barley, we used the laboratory method for the early diagnosis of the trait – the root test method.Results and conclusions. Field and laboratory screening revealed a fairly wide diversity of barley cultivated in Russia in terms of resistance to harmful organisms and the edaphic stressor. It was established that 24 barley cultivars were resistant to powdery mildew, and 14 accessions were carriers of the effective mlo11 allele. Two cultivars manifested combined resistance to powdery mildew and barley leaf rust. In 11 cultivars, a distinct greenbug resistance was revealed. High resistance to toxic aluminum ions according to the root and sprout length indices was observed in 26 cultivars. Accessions with the complex resistance to harmful organisms and the edaphic stressor were identified.
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- 2020
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10. Warfarin therapy in patients with coronary heart disease and atrial fibrillation: drug interactions and genetic sensitivity to warfarin
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O. A. Panibratiuk and O. А. Yakovleva
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bleeding on anticoagulation ,genetic polymorphism cyp2c9 ,interaction of warfarin ,slow metabolites ,warfarin ,Biochemistry ,QD415-436 ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
In this research work we examined the effect of various factors on the efficacy and safety of warfarin pharmacotherapy. Particular emphasis was placed on drug interaction in the standardized treatment of patients with coronary heart disease and atrial fibrillation. Since the administration of such drugs as digoxin and statins with warfarin leads to an increase in the blood level of all three drugs (they interact at the level of P-glycoprotein) and warfarin has a narrow therapeutic window, the risk of hemorrhagic complications is increased. For the first time in patients of the Podillya region of Ukraine, the genetic polymorphism of cytochrome CYP2C9 was determined, which is associated with the slow withdrawal of anticoagulant from the bloodstream and the possible risk of bleeding. For safe pharmacotherapy, patients were given significantly different doses of warfarin in all comparison groups, according to the International Normalized Ratiо (INR). For example, in the group with a CYP2C9 mutation present, the dose was 3.08 ± 0.25 mg versus 4.15 ± 0.22 mg in the non-mutation group (P = 0.008). In addition, in patients with genetic polymorphism of detoxification enzymes, significantly more bleeding events (light or clinically significant; critical organ bleeding) were observed, but among these patients bleeding occurred at an INR of 2.6 (despite the recommendations of the European Society of Cardiology, that the INR can be maintained within 2.0-3.0). Therefore, patients with CYP2C9 mutations require a personalized approach and control of the INR in a safer range (2.0 to 2.5) and consideration of drug interactions.
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- 2020
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11. Screening of powdery mildew resistant barley accessions from Ethiopia for tolerance to abiotic stressors
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R. A. Abdullaev, O. V. Yakovleva, I. A. Kosareva, E. E. Radchenko, and B. A. Batasheva
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hordeum vulgare ,blumeria graminis f. sp. hordei ,chloride salinity ,toxic aluminum ions ,Biotechnology ,TP248.13-248.65 ,Botany ,QK1-989 - Abstract
Background. Analyzing the adaptive potential of cultivated barley with the aim of using new genotypes selected and developed in the process of work is a priority trend in scientific research. The Ethiopian barleys adapted to a variety of soil and climate conditions are characterized by many valuable biological and agronomic traits. Of particular value are genotypes that combine resistance to harmful organisms and environmental stressors.Materials and methods. The collection accessions of Ethiopian barley possessing powdery mildew resistance were studied for tolerance to adverse edaphic factors (chloride salinity and high content of toxic aluminum ions in the soil). Resistance to abiotic stressors was assessed in laboratory experiments. In the study of salt tolerance, a ‘roll-based’ assessment technique was used, which takes into account the inhibition of root growth under salt (NaCl) stress conditions, compared with the reference conditions without salinization. Aluminum sensitivity of barley accessions was diagnosed in the early stages of plant development using the root test.Results and conclusions. A polymorphism of Ethiopian barleys for resistance to adverse edaphic factors was revealed. Twentyone new sources of barley resistance to toxic aluminum ions were identified, of which accessions k-8552 and k-22933 were classified as highly resistant. Accessions k-17554, k-19975, k-20029, k-20048, k-22752, k-23450 and k-25009 proved resistant to soil salinization. Barley accessions k-17554, k-22752 and k-25009 were characterized by complex resistance to powdery mildew, toxic aluminum ions, and chloride soil salinity.
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- 2020
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12. THE ROLE OF RIOCIGUAT IN THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONNECTIVE TISSUE DISEASE
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O. Ya. Vasiltseva, K. I. Ivanov, E. A. Devetyarova, and O. E. Yakovleva
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pulmonary hypertension (ph) ,pulmonary arterial hypertension (pah) ,pulmonary arterial hypertension associated with systemic connective tissue diseases (pah ctd) ,pah-specific therapy ,riociguat ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). Binding NO with sGC - enzyme catalyzes the synthesis of a signal molecule of cyclic guanosine monophosphate (cGMP), which plays an important role in the regulation of processes that affect vascular tone, proliferation, fibrosis and inflammation. Impaired bioavailability and/or responsiveness to endogenous NO has been implicated in the pathogenesis of cardiovascular and other diseases. Pulmonary arterial hypertension (PAH) is a well-known complication of systemic connective tissue diseases (CTD) and ranks second among the most common types of PAH after idiopathic PAH (IPAH). The usage of organic nitrates and other NO donors has limitations, including non-specific interactions of NO with various biomolecules, lack of response and the development of tolerance following prolonged administration. Compounds that activate sGC in NO-independent manner might therefore provide considerable therapeutic advantages. The purpose of this article is to provide contemporary data on the management and treatment of patients, as well as the role of specific therapy and the place of riociguat in the treatment of patients with CTD associated PAH
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- 2019
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13. EXPERIENCE OF IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION PATIENTS MANAGEMENT IN URAL FEDERAL DISTRICT: FEATURES OFOUTPATIENT-HOSPITAL INTERACTIONS
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S. V. Shalaev, M. V. Arkhipov, A. L. Iofin, A. N. Bykov, L. V. Evrgafova, O. E. Yakovleva, D. F. Nizamova, V. A. Balina, and E. V. Milovanova
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pulmonary arterial hypertension (pah) ,idiopathic pulmonary arterial hypertension (ipah) ,registry ,epidemiology ,treatment ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Idiopathic pulmonary arterial hypertension (IPAH) is a severe chronic and rapidly progressive disease with increasing pulmonary vascular resistance (PVR) due to the ongoing pathogenic processes in the vascular wall that lead to obstruction of small pulmonary arteries and arterioles. IPAH takes a small part in the structure among all forms of pulmonary hypertension (PH), the median survival of patients with IPAH before any PAH-specific therapy became available were about 2,8 years, and the average time from the manifestation of the disease to its diagnosis took 2-3 years. This article is an attempt to present an unified data of adult patients with IPAH in Ural Federal district, and describe PH patients medical care service. The article presents the experience of PH Medical Centers across Ural Federal District.
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- 2019
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14. Te questionnaire designed to measure structure and severity of emotional burnout among mothers of adolescents with schizophrenia
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K. V. Kmit, Y. V. Popov, V. V. Bocharov, and O. V Yakovleva
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emotional burnout ,maternal burnout ,adolescents ,schizophrenia ,questionnaire to measure burnout. ,Psychiatry ,RC435-571 - Abstract
Tis work is devoted to the problem of emotional burnout in the context of parent-child relationship. Te possibility of applying the concept of burnout is being considered in order to describe the processes that occur in parents whose children suffer from a chronic psychiatric disorder, the author’s point of view on the matter is being presented. Te necessity of creating a questionnaire to measure emotional burnout among mothers of children with schizophrenia is being justifed, the procedure of creation of the new questionnaire is described, and the results of its approbation are performed.
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- 2019
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15. Phytotoxicity of aluminum ions
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O. V. Yakovleva
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toxicity ,acid soil ,aluminum ,Biotechnology ,TP248.13-248.65 ,Botany ,QK1-989 - Published
- 2019
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16. Comparative Assessment of Augmentation of Antidepressant Therapy with Actovegin and Cerebrolysin in Hospital Psychogeriatric Practice
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T. P. Safarova, S. I. Gavrilova, and O. B. Yakovleva
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Psychiatry and Mental health ,Clinical Psychology ,Biological Psychiatry - Abstract
Background: depressions in elderly and senile patients often occur against the background of cerebral changes of vascular and atrophic origin and are combined with impaired cognitive functions. It is known that a decrease in the production of neurotrophic factors is one of the leading mechanisms in the pathogenesis of depression. Previously, the effectiveness of combined therapy with antidepressants and drugs with neuroprotective properties has been shown, but a differentiated approach to the appointment of neuroprotective adjuvants needs substantiation. The aim of the study was to carry out comparative evaluation of the effectiveness of two augmentation methods of antidepressant therapy with the inclusion of different neuroprotectors (actovegin or cerebrolysin) in the treatment of depression in the elderly. Patients and methods: the study included 2 groups of patients with a depressive episode of mild and moderate severity, comparable in terms of basic demographic and clinical parameters. Patients of the 1st group received antidepressants in combination with actovegin for a month. Patients of the 2nd group received cerebrolysin simultaneously with antidepressants. The effectiveness of therapy was assessed on the HAMD-17 and HARS scales; the level of cognitive functioning of patients was assessed using the MMSE scale. Results: the effectiveness of both used types of complex antidepressant therapy was demonstrated: both with the inclusion of actovegin and with the inclusion of cerebrolysin. In patients of both groups, against the background of a reduction in depressive symptoms, a significant (p < 0.01) improvement in cognitive functioning (according to the MMSE scale) was noticed by the end of therapy (without statistically significant differences between the groups). The inclusion of actovegin in the antidepressant therapy regimen for elderly patients proved to be effective regardless of the type of depression, but especially in the reduction of anxiety symptoms. Administration of cerebrolysin to depressed patients was more effective in anergic, asthenic, apathetic and adynamic depressions. Conclusion: augmentation of antidepressant therapy with actovegin and cerebrolysin should be considered effective and recommended for use in a psychogeriatric hospital.
- Published
- 2023
17. EVALUATION OF THE TRANSPARENCY OF LOCAL GOVERNMENT ACTIVITIES IN THE CONTEXT OF IMPROVING THE ELECTRONIC GOVERNANCE MECHANISM
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T. М. Lozynska and O. S. Yakovleva
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General Earth and Planetary Sciences ,General Environmental Science - Published
- 2023
18. The effect of the firing rate on the properties of chamotte from kaolin Kyshtym deposit
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O. V. Yakovleva, I. D. Kashcheev, and K. G. Zemlyanoi
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General Engineering - Abstract
Исследовано влияние скорости обжига обогащенного каолина Кыштымского месторождения на свойства шамота. Спецификой каолина Кыштымского месторождения является петрографическое разнообразие исходных пород, что отрицательно сказывается на его качестве как огнеупорного сырья. Изучены пластические свойства каолина, позволяющие формовать брикет без дополнительного использования связующих, включая воду. Исследования скорости, конечной температуры обжига и длительности выдержки при конечной температуре показали, что скорость подъема температуры в процессе обжига шамота несущественно влияют на качество получаемого шамота. В то же время повышение конечной температуры обжига и выдержки существенно влияет на качество и фазовый состав шамота, закономерно снижая его водопоглощение, увеличивая выход муллита и уменьшая количество непереродившегося свободного SiO2. Установлено, что максимальная температура обжига обогащенного каолина Кыштымского месторождения на шамот составляет 1350‒1400 оС, скорость подъема температуры 35‒45 оС/мин.
- Published
- 2022
19. Strategies of students’ information behaviour in the context of lifelong learning
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T. N. Noskova, O. V. Yakovleva, T. B. Pavlova, and E. Smyrnova-Trybulska
- Subjects
information behaviour ,strategies ,students ,ict tools ,lifelong learning ,electronic education environment ,teacher education ,Special aspects of education ,LC8-6691 - Abstract
Research objective. The research objective was to identify and analyse the general trends, manifested in the information behaviour of students in terms of realising and taking advantage of lifelong learning in the digital society. The authors attempted to answer the question: What is the specificity of modern students’ information behaviour strategies? Materials and methods. The research was based on the concept of “information behaviour”, considered by the authors as a system of actions to implement the processes of interaction with the information environment. In the conditions of digital society development, the effectiveness of information strategies largely depends on the adoption of the values of lifelong learning. In the context of the activity approach, information behaviour includes the motivational aspect (acceptance of the lifelong learning paradigm, motives of educational activity, relations, interests and orientations within the current learning stage) and the activity aspect (general learning strategies, approaches to new information acquisition, self-management strategies in the learning process, as well as the possession of modern tools to implement these strategies – ICT tools). The research methods included a survey and statistical analysis. During the survey, Russian and Polish students were asked to relate the degree of information behaviour characteristics to a five-point scale. Statistical analysis comprised descriptive statistics, including the distribution of answers for all respondents, comparative statistics for Polish and Russian students, and correlation analysis.Results of the study. The research results have showed that students understand the importance of lifelong learning and accept it as a value and requirement of the 21st century. However, their information behaviour is not always based on effective strategies. Educational activity is insufficiently supported by the use of ICT tools for self-management, goal setting, and construction of an individual educational route. Direct correlations were revealed between the readiness for lifelong learning and the development of initiative, responsibility, self-management, including the active use of specialised electronic tools. Information behaviour is associated with future professional activities. For example, for socially oriented professions, information behaviour comprises such features as openness and empathy.Conclusion. Based on the results obtained, recommendations for lecturers can be formulated to support the process of mastering the advanced strategies of information behaviour by students. Firstly, it is necessary to encourage students to use open electronic resources, not only to access the newest information, but to join the processes of qualitatively new knowledge creation in collaborate work (self-directed learning, learning in partnership, collaborative learning). Secondly, it is important to create conditions for the expansion of professional experience through the strengthening of the practice-oriented assignments role, as well as the inclusion of students in project, competitive and grant activities.
- Published
- 2018
- Full Text
- View/download PDF
20. THE CHANGE OF QUALITY OF SPRING SOFT WHEAT GRAIN DURING THE BREEDING
- Author
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V. G. Zakharov and O. D. Yakovleva
- Subjects
spring soft wheat ,grain quality ,crop rotation ,variety ,protein ,gluten ,Agriculture (General) ,S1-972 - Abstract
The article has presented the study results of grain quality of 14 spring soft wheat varieties as a variety change of the crop in the Ulyanovsk region. It has been shown that during the 60-year period the productivity increased on 1.02 t/ha due to zonation of the variety ‘Lyutestcens62’ and it had been increasing on 0.22 t/ha at each new stage of the variety change. In contrast to the productivity, the change of the grain qualitative indexes has a different tendency. It has been noted the increase of all physical indexes of grain quality, first of all 1000-kernel weight, which increased on 0.9 g as a result of breeding. The results of the correlation analysis showed that 1000-kernel weight has got a positive correlation with the kernels productivity (r=0.69**), uniformity (r=0.70**) and volume of bread (r=0.50). The content of protein and gluten tends to decrease. The difference in the content of protein among the varieties of the first and the sixth stages was 1.3%; the difference in the content of gluten was 3.3%. During the stages of the variety change the content of protein decreased on 0.25%, gluten on 0.27% without improvement of its quality. With the increase of the potential of new variety productivity the gross yield of protein and gluten per unit of square increases. The correlation analysis established a significant negative connection of the content of protein with productivity (r=-0.76*) and 1000-kernel weight (r=-0.55***). Due to the variety changes there is an improvement of volume of bread and general baking valuation. Among the varieties of different periods of the variety change, there have been found the varieties with high biochemical and baking traits.
- Published
- 2018
21. SURGICAL CORRECTION OF ISTHMIC CERVICAL INSUFFICIENCY IN NON-PREGNANT WOMEN: A CLINICAL CASE
- Author
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A. G. Yashuk, R. A. Naftulovich, R. M. Zainullina, E. M. Popova, and O. V. Yakovleva
- Subjects
pregnancy ,isthmic сervical incompetence ,miscarriage ,pretem birth ,cervical defects ,lash procedure ,Gynecology and obstetrics ,RG1-991 - Abstract
Clinicians often see a recurrent miscarriage caused by isthmic cervical incompetence. Today, obstetric pessaries and surgical sutures are widely used to correct cervical incompetence during pregnancy. The occurrence rate of this abnormality continues to rise, which emphasizes the need to diagnose and correct cervical incompetence prior to the upcoming pregnancy. In the available literature there is little information about the «hidden» defects of the cervix that can lead to miscarriage in the I-III trimesters of pregnancy. Here we present a case of two different pregnancy outcomes in a single patient with cervical incompetence before and after surgical correction of the cervix by the LASH procedure. The present case supports the importance of surgical correction of cervical incompetence in non-pregnant women.
- Published
- 2018
- Full Text
- View/download PDF
22. Analysis of adverse drug reactions of therapy with anticoagulants and basic drugs in coronary heart disease against the background of atrial fibrillation
- Author
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O. А. Yakovleva and O. A. Panibratiuk
- Subjects
General Medicine - Abstract
Annotation. The issue of effectiveness and safety of pharmacotherapy is extremely important for the patient. The doctor’s awareness of the selection of the most compatible drugs makes it possible to reduce the number of adverse drug reactions and increases his adherence to treatment. The purpose of the study is to assess the frequency of adverse drug reactions during therapy with anticoagulants: warfarin, rivaroxaban, dabigatran in the complex therapy of coronary heart disease and atrial fibrillation, if necessary to comply with ESC recommendations. For a comprehensive examination of the patient, the following research methods were used: anamnestic, laboratory screening of key body systems, instrumental, functional diagnostics, survey of the patient according to 60 key parameters of drug tolerance, pharmacogenetic method. Statistical data processing was carried out using variance analysis - One way ANOVA & LSD test. The intergroup reliability of the difference in quantitative values was calculated by % - according to the χ2 criterion. Indicators were evaluated in four comparison groups: Rivoroxaban, Dabigatran, Warfarin group with the presence of a genetic mutation of polymorphic alleles of SYP2C9 (SYP2C9*2, SYP2C9*3), which were associated with a slower metabolism of Warfarin and a higher frequency of hemorrhagic complications; and Warfarin group without mutations. Unfortunately, about 2% of patients have bleeding on the background of the use of 2 or more different anticoagulants in a separate period of time. And about 2.5% have ischemic complications on the background of their admission. From 0.25% to 1% die from complications of such therapy. Among other serious complications, there were complaints about the functioning of the digestive system (dysfunction of the pancreas, liver, biliary tract), nervous system, and kidneys. These complaints were present in all groups, but prevailed in the Warfarin group with an existing mutation, probably due to the slowing of the elimination of drugs metabolized by cytochromes CYP2C9, CYP3A4 or greater influence of interaction with P-glycoprotein (due to interaction with digoxin and statins). This requires additional study in order to optimize ways of correcting unwanted reactions in cariological patients. It is obvious that promising genetic research should also be more widely implemented in medical practice.
- Published
- 2022
23. Effect of Firing Rate on the Properties of Chamotte from Kyshtym Deposit Kaolin
- Author
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O. V. Yakovleva, I. D. Kashcheev, and K. G. Zemlyanoi
- Subjects
Materials Chemistry ,Ceramics and Composites - Published
- 2022
24. Levels of Protein Carbonylation and Activity of Proteases in the Brain of Newborn Rats with Prenatal Hyperhomocysteinemia
- Author
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A. V. Yakovlev, S. A. Dmitrieva, A. N. Krasnova, O. V. Yakovleva, and G. F. Sitdikova
- Subjects
Cellular and Molecular Neuroscience ,Molecular Biology ,Biochemistry - Published
- 2022
25. PEDAGOGICAL ACTIVITY TOOLS IN ELECTRONIC ENVIRONMENT
- Author
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T. N. Noskova, T. B. Pavlova, and O. V. Yakovleva
- Subjects
electronic educational environment ,pedagogical ict tools ,electronic educational resources ,pedagogical ict competences ,irnet project ,Education - Abstract
The paper introduces the concept of "pedagogical ICT tools", which makes it possible to identify the necessary professional teacher activity transformations in electronic educational environment. The paper presents the typology of tools and describes their features. The introduction of the concept allows revealing the range of opportunities and transformations of the university teachers' activity in electronic environment. Experimental data on the use of pedagogical ICT tools by teachers of European universities was obtained during the implementation ofthe European IRNet project.
- Published
- 2017
26. SURGICAL AND COMBINED TREATMENT OF CANCER OF THE THORACIC ESOPHAGUS IN PATIENTS OVER 60 YEARS OLD
- Author
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R. G. Badykov, V. V. Loboda, V. F. Chizhikov, R. R. Badykov, R. V. Safiullin, and O. G. Yakovleva
- Subjects
пищевод ,рак ,хирургическое и комбинированное лечение ,больные старше 60 лет ,Surgery ,RD1-811 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Results of surgery performed over a 15-year period on 328 patients over 60 years old with cancer of the thoracic esophagus are analyzed. Concomitant diseases, results of functional observation are reported. Data of surgical and combined treatment of cancer of the esophagus are presented. Types of operation, modification of resection and esophagoplasty are considered. Direct and remote results of treatment are considered.
- Published
- 2017
- Full Text
- View/download PDF
27. Difficulties in diagnosis of alcoholic fatty liver disease and metabolically associated fatty liver disease
- Author
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T. M. Masloyid, G. M. Mazur, Y. M. Pashinskyi, O. O. Yakovleva, and K. V. Pivtorak
- Subjects
General Medicine - Abstract
Annotation. According to many researchers, non-alcoholic fatty liver disease as an independent disease is underestimated by a large percentage of both patients and physicians. Asymptomatic course, lack of specific complaints leads to the fact that non-alcoholic fatty liver disease is detected by chance on the basis of the detected increase in transaminases or hepatomegaly, which is detected during examination for other pathologies. The high prevalence of the disease, as well as the increase in cardiovascular risk and the risk of hepatocellular carcinoma in non-alcoholic fatty liver disease requires the search for simple and reliable methods of detecting this pathology. We searched for studies that study the diagnostic accuracy of various methods for diagnosing nonalcoholic fatty liver disease and differentiated approaches to their use in scientometric databases PubMED/MEDLINE, EMBASE and the Cochrane Library. The use of the gold standard of diagnosis, namely, liver biopsy is limited by its invasive nature and high cost. The new concept of metabolically associated liver disease and the criteria for its diagnosis allow clinicians to identify more patients at risk of adverse outcomes in clinical practice. The most common and minimally sufficient is the ultrasound examination of the liver with elastography, which allows to assess both the indicators of steatosis and the degree of fibrosis. The diagnostic scales FLI, NAFLD liver fat score, NAFLD liver fibrosis score, APRI, FIB4 and fibromax test remain relevant for the diagnosis of fatty liver disease. Anthropometric diagnostic tests for screening diagnosis of non-alcoholic fatty liver disease are still relevant. Research is currently being conducted to study the epidemiology and mechanisms of development, which will reveal epidemiological and pathogenetic differences between metabolic associated fatty liver disease and non-alcoholic fatty liver disease, which will serve as a step towards the introduction of new diagnostic, prognostic and therapeutic measures.
- Published
- 2022
28. Effects of Moderate Chronic Stressing of Female Rats Before and During Pregnancy of Sensorimotor Development, Anxiety Levels, and Cognitive Functions in Their Offspring
- Author
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O. V. Yakovleva, K. S. Bogatova, V. V. Skripnikova, and G. F. Sitdikova
- Subjects
General Neuroscience - Published
- 2022
29. Some effects of a modern university educational environment informatization
- Author
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T. N. Noskova, T. B. Pavlova, and O. V. Yakovleva
- Subjects
electronic information educational environment ,information-rich environment ,openness ,cooperation ,individualization of learning ,Special aspects of education ,LC8-6691 - Abstract
The paper analyzes the effects that occur in the process of the educational environment informatization. The following effects were analyzed: information richness, openness, individualization of learning and collaboration. Examples of educational practice, illustrating the significant changes of the university educational environment associated with the manifestation of these effects, are presented. The aim of the pilot study carried out in Herzen University was to identify the attitude to the listed effects of teachers and students who are using information and communication technology in the educational interactions. The leading method of study were a series of surveys addressed to teachers and students. Groups of questions were related to basic information effects, manifested in the educational environment of the university. The total number of the survey participants is 200 students (bachelors and masters) and 100 teachers, most actively using electronic environment for research, education and professional activities. Qualitative and quantitative analysis of the results showed that information richness, spatial and temporal freedom of educational interactions are demanded by students, but at the same time, the data indicated a lack of systematic pedagogical support for the information and educational activities of students. A large part of students show a high autonomy in the information educational environment, but also demands implementing individualized information and communication educational request. Students and teachers are actively using a variety of information and communication opportunities of the electronic environment, but students’ activeness in the electronic environment is largely determined by the recommendations of teachers, rather than by a free choice of educational opportunities. The participants of the educational environment acquire a significant degree of freedom in relation to the time and place of interaction with educational resources, but evidence suggests that educational activities in the electronic environment is not sufficiently focused on expanding the range of educational opportunities and preparing students for continual self-improvement of knowledge and skills. As the conclusions, we note the need to improve both the corporate strategy of the university electronic environment development and the competences of educational interactions in the extended information and communication space. This will reveal the full potential of e-learning environment and provide greater guarantees for obtaining high-quality educational outcomes. For teachers are in demand special competences, providing the possibility of forming a diverse and adaptive media environment for saturated solution of educational problems in accordance with university policies, introduction of e-learning and global education trends. For students, come to the fore the competences which help to improve their information culture and individual requests for the use of a variety of educational opportunities available in the electronic space. These ideas are fully consistent with the demanded by modern society the lifelong learning strategy.
- Published
- 2016
- Full Text
- View/download PDF
30. Evaluation of Platelet Glutamate Dehydrogenase Activity in Late-Life Depressions
- Author
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O. K. Savushkina, E. B. Tereshkina, T. A. Prokhorova, I. S. Boksha, T. P. Safarova, O. B. Yakovleva, V. V. Kornilov, E. S. Shipilova, E. A. Vorobyeva, and G. Sh. Burbaeva
- Subjects
General Medicine - Abstract
The aim of the study is to evaluate the activity of platelet glutamate dehydrogenase (GDH) in late-life depression compared to the healthy control group and to reveal possible correlations with clinical data. Patients and methods: 42 elderly patients (60–86 years old) with depressive episodes of different nosological categories according to ICD-10 were examined: a single depressive episode (F32.0, F32.1), a depressive episode in recurrent depressive disorder (RDD — F33.0, F33.1) and a depressive episode in bipolar affective disorder (BD — F31.3). The activity of GDH and the severity of depression (using the Hamilton depressive scale, HAMD-17, and the Hamilton scale for assessing anxiety, HARS) were evaluated twice: before the starting the course of antidepressant therapy (day 0) and on the 28th day of the treatment course. Results: patients showed a significant decrease in the activity of GDH compared to the control group (p < 0.0008). Before the treatment, GDH activity was significantly reduced compared to the control in both RDD and BD (p < 0.002 and p < 0.004), whereas after the treatment, the decreased GDH activity was observed only in patients with BD (p < 0.002). When compared with the control group, male patients showed a significant decrease in GDH activity both before and after the treatment course (p < 0.017 and p < 0.027), whereas women patients showed the decrease only before the treatment (p < 0.014). Conclusion: the decreased platelet GDH activity in elderly depressions may indicate an impairment of glutamate metabolism. Gender differences were revealed in the reversal of GDH activity level after the therapy: in men, the level of GDH activity did not recover to control values after the treatment course. An elevation in the level of GDH to control values over a 28-day course of therapy occurred only in patients with RDD, but not in patients with BD.
- Published
- 2021
31. CORRELATION OF MORPHOANATOMICAL TRAITS WITH LODGING RESISTANCE IN SPRING WHEAT IN THE MIDDLE VOLGA REGION
- Author
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V. G. Zakharov, V. V. Syukov, and O. D. Yakovleva
- Subjects
spring wheat ,lodging ,morphoanatomical traits ,correlation ,regression ,principal component ,path analysis ,Genetics ,QH426-470 - Abstract
The study concerns the variability of dual lodging resistance and morphoanatomical indices of the culm in 17 spring wheat varieties. Factor, path, and multivariate regression analyses indicate that reliable direct and indirect contributions to plant resistance to lodging are made by the lengths of the second and third lower internodes, the sum of their lengths, and the fractural strength of the culm at lower internodes. It is shown that the selection for lodging resistance in spring wheat can be done in early generations on the base of the lengths of lower internodes.
- Published
- 2015
32. EFFECT OF HYDROGEN SULFIDE ON ATRIUM CONTRACTILITY IN CONTROL AND DIABETHIC MICE
- Author
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A. S. Lifanova, O. V. Yakovleva, A. I. Zefirov, and G. F. Sitdikova
- Subjects
предсердия мыши ,l-цистеин ,сахарный диабет ,аллоксан ,Medicine - Abstract
Hydrogen sulfide (H2S) is endogenously synthesized gasotransmitter that has a regulatory effect in cardiovascular system. Diabetes mellitus leads to an increased risk of hypertension and cardiovascular diseases, so the purpose of the study was to analyze the contractility of the atria mice after application of L-cysteine and H2S. Contractile activity of the myocardium was investigated in the experiment on isolated mouse atria. Alloxan was used for modeling diabetes. Intraperitoneal injection of alloxan resulted in a significant increase of glucose concentration in blood, whereas the concentration of glucose didn’t change at the injection of physiological solution. In control, the addition of NaHS resulted in a significant dose-dependent decrease of the amplitude of contraction of the myocardium, whereas the negative inotropic effect of NaHS was significantly lower in terms of modeling diabetes compare to control conditions. In the control, L-cysteine reduced the amplitude contractions significantly, whereas L-cysteine did not lead to significant changes in the amplitude of contractions in terms of modeling diabetes. These data indicate that the sensitivity of mice’s atria reduced for H2S and L-cysteine in diabetes mellitus.
- Published
- 2014
- Full Text
- View/download PDF
33. Modification of Polyacrylonitrile Fibers with Silk Fibroin Nanoparticles. Dyeing of Pan Fiber with Fibroin Nanoparticles by Acid Dyes
- Author
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O. I. Yakovleva, E. S. Sashina, and I. A. Nabieva
- Subjects
Silk waste ,General Chemical Engineering ,fungi ,Polyacrylonitrile ,Fibroin ,Nanoparticle ,General Chemistry ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,Mixed materials ,General Materials Science ,Fiber ,Dyeing - Abstract
The effect of treatment of polyacrylonitrile (PAN) fibers with nanoparticles of silk fibroin on the dyeability of fibers with acid dyes was investigated. As a result of the attachment of oligomeric protein fragments containing amino groups to the fibers the affinity of the anionic dye to the fibers increases. Modification of PAN fibers with oligomers of fibroin obtained from silk waste can be recommended for the dyeing of mixed materials and articles.
- Published
- 2021
34. The Effect of Three-Month Atorvastatin and α-Calcidol Administration on Some Bone Tissue Morphometric Parameters
- Author
-
S. S. Asachuk, O. S. Yakovleva, A. F. Martsinkevich, and Е. A. Karpenkа
- Subjects
0301 basic medicine ,Atorvastatin ,Common disease ,Osteoporosis ,Combined use ,Dentistry ,Bone tissue ,01 natural sciences ,osteogenesis ,statins ,010104 statistics & probability ,03 medical and health sciences ,medicine ,Van Gieson's stain ,Vitamin D and neurology ,Femur ,0101 mathematics ,Orthopedic surgery ,business.industry ,vitamin d ,atorvastatin ,medicine.disease ,α-calcidol ,osteoporosis ,030104 developmental biology ,medicine.anatomical_structure ,business ,human activities ,RD701-811 ,medicine.drug - Abstract
Background.Osteoporosis is the fourth most common disease after cardiovascular diseases, cancer, and diabetes. All these diseases have common pathogenetic mechanisms associated with impaired cholesterol metabolism. In recent decades, the use of the key enzyme of cholesterol synthesis inhibitors — statins, which can stimulate osteogenesis, has become widespread. However, statins affect the production of the vitamin D active form by reducing the production of testosterone and thus reducing the activity of 1α-hydroxylase. The combined use of statins and α-calcidol (α-C) for the osteoporosis prevention seems promising. The aim of the study was to evaluate the effect of long-term atorvastatin (ATV) and α-C administration on morphometric growth parameters and bone vascularization in the experiment.Materials and Methods. The experiment was conducted for three months on 120 laboratory male rats, which were injected daily intragastrically with ATV and α-C. After 90 days of the experiment, the animals were decapitated under ether anesthesia. For the study, the right femur and jawbone were taken from the animals. The rat bone sections were impregnated with silver, decalcified, and the histosections were stained according to van Gieson. The distribution of the studied features was evaluated according to the Shapiro-Wilk test. The differences were considered statistically significant at p0.05.Results.It was found that ATV, both separately and together with α-C, increased the size of the newly formed bone in the endoostal and periosteal zones of the femur by 64.8; 40.4 and 15.8; 29.1%, respectively. The combined use of ATV and α-C had a positive effect on the growth of blood vessels in the femur (+23.4%). ATV increased the size of the newly formed bone from the periodontal and vestibular surfaces of the lower jaw by 18.3 and 29.5%, respectively. α-C potentiated the effect of ATV on the size of the newly formed bone tissue in the periodontal and vestibular growth zones of the mandibular bone by 10.1 and 15.0%, respectively. As for the number of vessels in the jawbone tissue, thanks to ATV, it increased by 17.2%, α-C had no effect.Conclusion. ATV increases the thickness of the newly formed bone layer in the growth areas of the femur and jawbone and increases the number of vessels in the jawbone. α-calcidol increases the number of vessels in the bone tissue of the femur and potentiates the effect of ATV on the jawbone growth zones. The combined use of ATV and α-C shows that they positively complement each other.
- Published
- 2021
35. Modern concepts of low birth weight and fetal growth restriction
- Author
-
O V Yakovleva, I E Rogozhina, and T N Glukhova
- Subjects
Pregnancy ,medicine.medical_specialty ,Fetus ,medicine.diagnostic_test ,business.industry ,Obstetrics ,Umbilical artery ,General Medicine ,medicine.disease ,Preeclampsia ,Low birth weight ,medicine.artery ,embryonic structures ,medicine ,Gestation ,Cardiotocography ,medicine.symptom ,business ,Ductus venosus - Abstract
The aim of this work is to study the state of the problem of the development of small-for-gestational-age fetus and fetal growth restriction over the past 5 years. A review of randomized trials of the PubMed database for the period of 2015 to 2020 was carried out. Experts reached an agreement on the definition of diagnostic criteria for small-for-gestational-age fetus and fetal growth restriction, a clinically valid classification was created, and the main monitoring strategies were developed. Due to the different pathogenesis, fetal growth restriction is divided into early and late. The observation algorithm includes tests that have shown higher sensitivity and specificity. There is no single standard for the median weight and abdominal circumference of a fetus, indicators of the reference range for fetal Doppler. Smoking cessation and taking acetylsalicylic acid at a dose of 150 mg at high risk of preeclampsia is recommended to prevent the small-for-gestational-age fetus and fetal growth restriction. The pregnancy management algorithm includes Doppler ultrasound examination of the umbilical artery, cardiotocography. If this pathology occurs before 32 weeks of pregnancy, the blood flow in ductus venosus is additionally examined, and after 32 weeks of pregnancy, the middle cerebral artery blood velocities and cerebroplacental ratio are assessed. Indicators of Doppler velocimetry and cardiotocography, which serve as criteria for early termination of pregnancy, are developed, measures are proposed to improve neonatal outcomes prevention of respiratory distress syndrome at 2434 weeks of gestation, as well as magnesium therapy for fetal neuroprotection. The problems of preventing fetal growth restriction and the algorithm for monitoring pregnant women who do not have risk factors for small-for-gestational-age fetus, management tactics and indications for delivery while slowing fetal weight gain remain unresolved.
- Published
- 2021
36. DIFFICULTIES COMPREHENSIVE CLINICAL DIAGNOSIS OF PNEUMONIA IN THE HOSPITAL AGAINST TRAUMATIC BRAIN INJURY.
- Author
-
A. B. Ilchenko and O. O. Yakovleva
- Subjects
госпітальна пневмонія ,нозокоміальна пневмонія ,черепно-мозкова травма ,ЧМТ ,діагностика. ,Medicine - Abstract
Nosocomial pneumonia (NP) holds a leading position in the structure of in-hospital morbidity and mortality. NP is one of the most dangerous infectious complications of severe traumatic brain injury (TBI). Clinical diagnosis of pneumonia in severe head injury remains challenging and continues to be developed. The aim of the study is research was to find out the features of the clinical and laboratory diagnosis of NP, developed on the background of TBI. Materials and methods. The sample of 166 patients, including 58 patients with isolated severe head injury (group 1) and 108 patients with TBI, complicated by the development of NP (group 2). All patients in Group 2 NP was confirmed by the radiography presence of infiltrates. Diagnosis of NP was established in accordance with international recommendations and the current Ukrainian protocol of diagnosis and treatment of pulmonary diseases in adults (decree of Ministry of Health of Ukraine No. 128 from 19.03.2007). In both groups we considered the complaint, physical examination and laboratory investigations of patients with conventional diagnosis in NP. Results and Discussion. The following figures are obtained. The average score on the Glasgow coma scale (GCS) in group 1 was 12.0±3.0 points, group 2 – 10.3±3.3 points. The mean duration of mechanical ventilation in group 1 was 4.2±2.7 days, and in group 2 – 9.7±6.8 days. The average heart rate was 77.9±10.3 in group 1 and 95.0±11.3 in group 2. The average body temperature figure was 37.1±0.5 in the first group and 38.7±0.8 in the second group. In group 1, the erythrocyte sedimentation rate (ESR) index was 8.8±4.9 mm/h, leucocytes 8.0х109±3.3. leukocyte index of intoxication (LII) 2.0±0.8. In group 2, ESR rate was 30.6±13.4 mm/h, leucocytes 20.4 х109±6.6, LІI 5.9±3.4. Conclusions. Thus, conventional clinical and laboratory diagnostic techniques have different nosocomial pneumonia (often low) level of sensitivity and specificity, as a result, no single criterion can not be the gold standard for the diagnosis of SE. Considering the clinical relevance of the SE and a high risk of its development in patients with TBI, today is a topical issue of new research GP diagnostic methods based on the most sensitive indicators and their complex application.
- Published
- 2017
- Full Text
- View/download PDF
37. INTERMEDIATE DIMENSIONS OF J. LITTELL’S 'THE KINDLY ONES': FORM-BUILDING PRINCIPLES OF BAROQUE SUITE
- Author
-
O. S. Semenets and O. М. Yakovleva
- Subjects
Baroque ,media_common.quotation_subject ,Suite ,Art history ,Art ,media_common - Published
- 2021
38. Investigation of a method for producing non-woven needled felt from silk-spinning waste
- Author
-
O. A. Moskalyuk, O. M. Ivanov, E. S. Sashina, and O. I. Yakovleva
- Subjects
SILK ,Materials science ,Polymer science ,Spinning - Published
- 2021
39. INTERNATIONAL SEVERE WARNING REQUIREMENTS AND SMART DECISIONS IN CHOICE TACTICS FOR FLUOROQUINOLONES
- Author
-
O. O. Yakovleva and O. Yu. Hoina-Kardasevich
- Subjects
General Medicine - Abstract
The paper is devoted to the review of the reports on current ideas about adverse reactions of using the fluoroquinolones. As a group of antibiotics with a wide range of effects on microbial pathogens, they have recently found a sufficient use in infectious diseases in clinical practice. However, the spread of indications is accompanied by the accumulation of information about the growth of adverse reactions. Among the first mentioned ones there were reactions in gastrointestinal tract, allergic reactions, photosensitization, prolongation of the QT interval, deterioration of joint and tendon function, lesions of the nervous system. Some toxic reactions contributed to the banning of certain drugs: temafloxacin, grepafloxacin, trovafloxacin. Further observations were made on the development of hypoglycemic reactions, eosinophilia, liver damage. Among the mechanisms of toxicity the free radical reactions, structural modifications of the antibiotic molecule are considered. Therefore, both the United States (FDA) and European experts are paying close attention to serious warnings to limit the indications for these drugs. Some studies have shown an increase in the frequency of tendon rupture, as well as the risk of aortic aneurysm and its rupture, due to the mechanisms of effects on collagen metabolism, widely present in the tissues of the joints and surrounding tissues and in the aorta. The reports demonstrate the frequency of lesions to joints, muscles, nervous system and separately formulated complications in the mental sphere of patients. The accumulation of information on the injury of the nervous system and mental disorders resulted in the proposal to limit the indications for the easy course of infections, with their recurrence in urinary tract infections, diarrhea prevention. Restrictions also include as follows: old age of patients, previous anamnestic reactions to these drugs, diseases of the joints and kidneys, interaction with glucocorticoids. Key words: fluoroquinolones, adverse reactions, restrictions on indications, international recommendations.
- Published
- 2020
40. Non-Woven Needle Punched Material with Silver Nanoparticles from Natural Silk Fiber Waste
- Author
-
M. I. Osipov, E. S. Sashina, G. P. Smirnov, and O. I. Yakovleva
- Subjects
Silk fiber ,Materials science ,General Chemical Engineering ,Sorption ,General Chemistry ,Chloride ,Silver nanoparticle ,Silver nitrate ,chemistry.chemical_compound ,Ammonia ,SILK ,Chemical engineering ,chemistry ,medicine ,General Materials Science ,Fiber ,medicine.drug - Abstract
Non-woven needle-punched material with silver nanoparticles was obtained from the waste of natural silk cocooning process. Silver nanoparticles were synthesized by chemical reduction from an ammonia solution of silver nitrate. It is shown that the treatment of silk material with a solution of 1-butyl-3-methylimidazolium chloride affects the amorphous-crystalline state of the fiber, its sorption properties and the resistance of silver nanoparticles on the fiber to wet treatments.
- Published
- 2020
41. Modification of Polyacrylonitrile Fibers with Fibroin Nanoparticles. Production and Attachment of Fibroin Nanoparticles to Pan Fiber
- Author
-
E. S. Sashina, I. A. Nabieva, and O. I. Yakovleva
- Subjects
010407 polymers ,Aqueous solution ,Chemistry ,General Chemical Engineering ,fungi ,Polyacrylonitrile ,Fibroin ,Nanoparticle ,Infrared spectroscopy ,02 engineering and technology ,General Chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,Chemical engineering ,General Materials Science ,Itaconic acid ,Fiber ,Absorption (chemistry) ,0210 nano-technology - Abstract
An aqueous solution of fibroin nanoparticles, obtained as a result of thermal hydrolysis of the waste products from silk fibers, was used to modify polyacrylonitrile fibers. According to light scattering data, the fibroin nanoparticles in aqueous solution had hydrodynamic radii of 75-95 nm. It was established by chromato-mass spectroscopy that the nanoparticles contain oligomeric fragments of a polypeptide chain and the products from their condensation with the formation of cyclic diketopiperazines. In the IR spectra of the fibers after treatment with fibroin nanoparticles there are bands associated with the absorption of N–H groups. The intermolecular interaction between the carbonyls of PAN in the fiber and the active groups of the fibroin oligomers can be judged from the shift of the C=O bands of itaconic acid into the low-frequency region and from the increase in the absorption of the ester groups. Strong attachment of the fibroin nanoparticles to the PAN fiber is favored by chemical reaction between the carboxyls of the itaconic acid in the structure of the fiber and the amino groups of the fibroin fragments. The increase of the relative nitrogen content after modification of the PAN fibers with fibroin nanoparticles is confirmed by the results of elemental analysis.
- Published
- 2020
42. Modeling the Process of Synthesis of Nanoparticles into Fibrous Materials by the Method of Chemical Reduction
- Author
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E. S. Sashina, S. A. Vakulenko, and O. I. Yakovleva
- Subjects
Matrix (chemical analysis) ,SILK ,Materials science ,Chemical engineering ,Reducing agent ,General Chemical Engineering ,Scientific method ,Nanoparticle ,General Materials Science ,General Chemistry ,Reduction (mathematics) ,Perceptron ,Nonlinear regression - Abstract
Silk fibers served as a matrix for the reduction of nanoparticles from a silver salt solution. A mathematical model describing the dependence of the total content of reduced silver on a fiber Y on the input parameters X1, X2, X3, X4 (silver concentration in the treatment solution, concentration of reducing agent, temperature and duration of the reduction process, respectively) is constructed. A chemically substantiated nonlinear regression model and a two-layer perceptron are proposed, which make it possible to obtain mathematical expressions for the dependence of the silver content on silk fibers on the input parameters. Both models adequately reflect the experimental data – the error of the regression model is 0.16, the error of the two-layer perceptron is 0.14.
- Published
- 2020
43. Thermal Expansion and Shrinkage of Unidirectional Composites at Elevated Temperatures
- Author
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O. S. Yakovleva, M. K. Kucher, and O. O. Chyzhyk
- Subjects
0209 industrial biotechnology ,Materials science ,020502 materials ,Composite number ,Thermal deformation ,Absolute value ,02 engineering and technology ,Thermal expansion ,Matrix (mathematics) ,020901 industrial engineering & automation ,0205 materials engineering ,Mechanics of Materials ,Solid mechanics ,Polymer composites ,Composite material ,Shrinkage - Abstract
The model of multiphase media analyzes the effectiveness of describing thermal expansion and shrinkage of unidirectional polymer composites at their uniform heating by linear law. It is shown that the nature of change in thermal deformation as a function of the composite temperature is similar for an unreinforced matrix, and the maximum absolute value of chemical shrinkage is slightly lower than that of a matrix. The calculated deformations describing thermal expansion are compared with experimental deformations obtained in the process of thermal-oxidative destruction.
- Published
- 2020
44. Sleep and Cognitive Impairments in Neurodegenerative Diseases
- Author
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O. S. Levin, E. A. Lyashenko, M G Poluektov, and O. V. Yakovleva
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Lewy body ,business.industry ,General Neuroscience ,Cognition ,Disease ,medicine.disease ,Sleep in non-human animals ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Physical medicine and rehabilitation ,Medicine ,Dementia ,business ,030217 neurology & neurosurgery - Abstract
Impairments of sleep and waking in diseases such as Parkinson’s disease, dementia, Lewy body dementia, and Alzheimer’s disease are encountered in a large proportion of patients. Sleep has many functions, supporting the normal operation of the brain, and impairments to sleep may be among the factors promoting the development of neurodegenerative diseases. Impairments to sleep and waking may exacerbate the course of the neurodegenerative process and lead to increases in symptoms, including cognitive impairments. This article presents a detailed analysis of the literature linking sleep and waking impairments and cognitive impairments in neurodegenerative diseases. The phenomenology and methods of correcting sleep and waking impairments in these diseases are discussed.
- Published
- 2020
45. ОРГАНІЗАЦІЯ ПРОФІЛАКТИЧНОЇ РОБОТИ У ЦЕНТРІ ПЕРВИННОЇ МЕДИКО-САНІТАРНОЇ ДОПОМОГИ
- Author
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O. G. Yakovleva
- Abstract
У статті висвітлено основну мету профілактичної роботи та формування у населення мотивованого відповідального ставлення до власного здоров’я, здорового способу життя, зміцнення здоров’я населення, зниження захворюваності та смертності.
- Published
- 2020
46. Effectiveness of cerclage for the prevention of premature birth depending on the suture material used
- Author
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A. A. Tyurina, A. V. Maslennikov, O. V. Yakovleva, A. G. Yashchuk, and R. R. Zagidullina
- Subjects
medicine.medical_specialty ,Suture (anatomy) ,business.industry ,Premature birth ,medicine ,business ,medicine.disease ,Surgery - Abstract
The purpose — to compare the effectiveness of cerclage to reduce the frequency of preterm birth when using non-absorbable suture material in the form of a braided silk thread (4 mm) and a braided tape (5 mm), as well as to identify the frequency of complications when using them. Material and methods. A retrospective analysis of cases and childbirth was conducted, as well as the analysis of own experience of applying cerclage with various suture materials in patients with isthmic-cervical insufficiency. A total of 157 patients were examined. Pregnancy outcomes, neonatal outcomes, and post-suture complications were evaluated. Results. 157 women were given cerclage at gestation periods of 14 to 23 weeks. There was no significant difference in the choice of suture material relative to the duration of pregnancy. Cerclage with thread was performed in 92 patients (58,6%) — group 1 and 65 patients were sutured with tape (41,4%) — group 2. Preterm birth occurred in 28 patients of the 2nd comparison group (18%) and 45 patients of the 1st group (29%). The duration of pregnancy in preterm birth was comparable in both groups. Conclusions. The study found that preterm birth after cerclage using a braided tape occurred less frequently than with the use of a braided silk thread. There were no significant differences in neonatal outcomes in the comparison groups. Complications after cerclage, such as suture and cervical rupture, were found only in the group of women who underwent surgery using a woven silk thread.
- Published
- 2020
47. METABOLIC SYNDROME PREVALENCE IN RUSSIAN CITIES
- Author
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O. P. Rotar, R. A. Libis, E. N. Isaeva, A. M. Erina, D. A. Shavshin, E. V. Moguchaya, E. P. Kolesova, M. A. Boyarinova, N. V. Moroshkina, O. I. Yakovleva, V. N. Solntsev, A. O. Konradi, and E. V. Shlyakhto
- Subjects
metabolic syndrome ,arterial hypertension ,obesity ,dyslipidemia ,cardiovascular disease ,waist circumference ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Aim. Metabolic syndrome (MS) is a combination of the key cardiovascular risk factors, namely obesity, carbohydrate metabolism disturbances, arterial hypertension (AH), and dyslipidemia. MS prevalence varies, depending on the MS definition used. The aim of this study was to assess the prevalence of MS and its components in large Russian cities (St. Petersburg, Kursk, Orenburg, and Kaliningrad), using international MS criteria. Material and methods. In total, 1046 individuals were screened in 4 cities: 309 in St. Petersburg, 170 in Kursk, 279 in Orenburg, and 288 in Kaliningrad. All participants underwent a questionnaire survey on demographics, risk factors, lifestyle, family history, comorbidities and treatment. Blood pressure measurement (3 measurements on the right arm) and anthropometry were also performed. Lipid profile and fasting glucose levels were measured with the use of Hitachi-902 analyser (Roche Diagnostics). MS was diagnosed based on the criteria by ATP III (2001–2005), IDF (2005), and JIS (2009). Results. High prevalence of MS was observed regardless of the criteria used; the highest prevalence was registered for the JIS-2009 criteria. For all MS criteria, no significant difference in MS prevalence was registered across the cities, or between men and women in each city. The majority of the patients (over 80%, regardless of the criteria used) had at least one MS component, with the highest prevalence observed in Kursk (94% for IDF-2005 and JIS-2009 criteria). Conclusion. In each region, the prevalence of MS was high, which might be related to high levels of cardiovascular morbidity and mortality in Russia. The IDF-2005 criteria agreed with the JIS-2009 ones to a greater extent than with the ATP III definition. However, prospective studies are needed to establish the national normal values of waist circumference, for reliable diagnostics of abdominal obesity in the Russian population.
- Published
- 2012
48. N-Acetylaspartate Levels in Elderly Patients with Depression during Treatment with Antidepressants and Actovegin
- Author
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I. I. Miroshnichenko, E. S. Shipilova, N. V. Baymeeva, O. B. Yakovleva, and T. P. Safarova
- Subjects
0301 basic medicine ,medicine.medical_specialty ,business.industry ,General Neuroscience ,Leukoaraiosis ,Fluvoxamine ,Venlafaxine ,Treatment efficacy ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Internal medicine ,Cohort ,medicine ,In patient ,business ,N-acetylaspartate ,030217 neurology & neurosurgery ,Depression (differential diagnoses) ,medicine.drug - Abstract
Objectives. To study the N-acetylaspartate (NAA) content in the plasma of elderly patients with depression during treatment with antidepressants combined with Actovegin. Materials and methods. Nineteen patients – seven men, 12 women, age 70.5 ± 5.8 years – were treated in hospital conditions. Patients underwent clinical psychiatric evaluation using a series of psychometric scales, along with computerized tomography (CT) and biochemical assay of NAA. Patients received antidepressants (venlafaxine and fluvoxamine at therapeutic doses) and Actovegin for 28 days and were investigated before and after treatment (day 28). Results and conclusions. Decreases in blood NAA were found in pretreatment patients as compared with healthy subjects, with increases after treatment, which corresponded to a significant improvement in patients’ status both clinically and on psychometric scales. Heterogeneity was found in the cohort of patients in relation to the nature of changes in contents (increases or decreases) of NAA, which was not linked with treatment efficacy but correlated with the burden of comorbid somatic diseases, especially vascular, and some CT features (leukoaraiosis). The authors emphasize the preliminary nature of the results.
- Published
- 2019
49. Current views on the possibility of cervical insufficiency correction
- Author
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T N Glukhova, O V Yakovleva, and I E Rogozhina
- Subjects
Pessary ,medicine.medical_specialty ,Pregnancy ,Cervical insufficiency ,progestogen ,Progestogen ,business.industry ,Obstetrics ,medicine.medical_treatment ,lcsh:R ,cerclage ,lcsh:Medicine ,General Medicine ,Abortion ,obstetric pessary ,medicine.disease ,medicine.anatomical_structure ,Premature birth ,Recurrent miscarriage ,Medicine ,business ,Cervix - Abstract
The main role in spontaneous abortion in 2nd and 3d trimesters is assigned to cervical insufficiency. According to a number of researchers, bed rest, elevated lower limbs, restriction of physical activity, tocolysis, antibacterial therapy do not affect the prolongation of pregnancy and are ineffective for preventing premature spontaneous labor. Correction of cervical insufficiency can be carried out by a vaginal form of progesterone, cerclage, pessary. The use of vaginal progesterone is justified in women with recurrent miscarriage, a history of premature birth, and shortening of the cervix to less than 25 mm. Indications for surgical correction are limited to patients with habitual loss of pregnancy due to cervical weakness or a history of premature birth. In the absence of significant obstetric history, cerclage has no advantages over the use of progesterone. The optimal time for cerclage is up to 20 weeks of pregnancy. Unlike progesterone cerclage has complications, the frequency and severity of which are attributable to the timing and indications for correction. Transabdominal cerclage is performed only when there is a technical impossibility of vaginal access due to the absence of a vaginal part of the cervix or after unsuccessful attempts of vaginal cerclages. Most often, the use of a pessary is associated with the diagnosis of a short cervix in terms of more than 24 weeks of gestation in the absence of an aggravated history. The combined use of gestagens, pessary and cerclage does not increase the efficiency of carrying a singleton pregnancy. Methods for the prevention of preterm delivery in multiple pregnancy, such as the introduction of a specialized outpatient service, bed rest, antibacterial therapy, progesterone, preventive cerclage or the insertion of a pessary do not change the incidence and mortality of newborns.
- Published
- 2019
50. [Platelet glutathione reductase and glutathione-S-transferase in elderly patients with depression]
- Author
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Savushkina Ok, T. P. Safarova, T A Prokhorova, O. B. Yakovleva, E. S. Shipilova, G. Sh. Burbaeva, and E B Tereshkina
- Subjects
medicine.medical_specialty ,Glutathione reductase ,Pilot Projects ,Gastroenterology ,Internal medicine ,Hamd ,medicine ,HARS ,Humans ,Platelet ,Bipolar disorder ,Depression (differential diagnoses) ,Aged ,Glutathione Transferase ,Aged, 80 and over ,biology ,business.industry ,Depression ,Middle Aged ,medicine.disease ,Glutathione ,Psychiatry and Mental health ,Glutathione S-transferase ,Glutathione Reductase ,biology.protein ,Biomarker (medicine) ,Female ,Neurology (clinical) ,business - Abstract
To compare the activity of platelet glutathione reductase (GR) and glutathione-S-transferase (GST) in elderly patients with depression and in the control group, and to identify a possible relationship between the activity of these enzymes and clinical parameters of the disease.We examined 42 elderly patients (60-86 years old) with depressive episodes of various nosological categories according to ICD-10: a single depressive episode (F32.0, F32.1), a depressive episode in recurrent depressive disorder (RDR - F33.0, F33.1), and a depressive episode in bipolar disorder (BD - F31.3). The GR, GST activity and the severity of depression were assessed twice: before the beginning of the course of 28-day antidepressant therapy (day 0) and on the 28th day of the course of therapy, using the Hamilton Depressive Scale (HAMD-17) and the Hamilton Anxiety Scale (HARS).As compared with the control group, a significant decrease in GST activity was found in patients before and after the course of therapy (A pilot study has revealed a decrease in platelet GST activity, and a link between platelet GR activity and the severity of depression after a course of therapy. The results obtained indicate the promise of further study of glutathione metabolism enzymes as a biomarker for assessing the state.Сравнительная оценка активности тромбоцитарных глутатионредуктазы (GR) и глутатион-S-трансферазы (GST) у больных с депрессией пожилого возраста и контрольной группы и выявление возможной связи активности этих ферментов с клиническими параметрами заболевания.Обследовано 42 пациента пожилого возраста (60—86 лет) с депрессивными эпизодами разных нозологических категорий по МКБ-10: однократного депрессивного эпизода (F32.0, F32.1), депрессивный эпизод в рамках рекуррентного депрессивного расстройства (РДР — F33.0, F33.1) и депрессивный эпизод при биполярном аффективном расстройстве (БАР — F31.3). Активность GR, GST и тяжесть депрессии оценивались дважды: до начала курса 28-дневной антидепрессивной терапии (0 день) и на 28-й день курса терапии с использованием шкалы Гамильтона для оценки депрессии (HAMD-17) и шкалы Гамильтона для оценки тревоги (HARS).У пациентов обнаружено достоверное снижение активности GST по сравнению с контрольной группой до начала и после курса терапии (Пилотное исследование выявило снижение активности тромбоцитарной GST у больных с депрессиями и связь активности тромбоцитарной GR с выраженностью депрессии после курса терапии. Полученные результаты свидетельствуют о перспективности дальнейшего изучения ферментов глутатионового обмена в качестве биомаркера для оценки состояния пожилых больных с депрессиями.
- Published
- 2021
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