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1. Additive negative prognostic value of coronary flow reserve in patients with left bundle branch block without inducible ischemia and without known coronary artery disease

Author

N Boskovic, V Giga, S Dedic, M Ostojic, T Karadzic, I Rakocevic, S Aleksandric, O Petrovic, M Tesic, I Jovanovic, I Nedeljkovic, M Banovic, B Beleslin, and A Djordjevic-Dikic

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background Left bundle branch block (LBBB) can be isolated thing, but it is also often associated with underlying coronary artery disease (CAD). Stress echocardiography (SECHO) is widely used as an imaging method for the diagnosis of CAD. However, the diagnostic value of stress echocardiography in patients (pts) with LBBB is limited. Purpose To evaluate negative prognostic value of coronary flow reserve (CFR) in pts with LBBB without inducible ischemia and without known CAD. Methods This retrospective study included 224 pts (98, 43.8% male gender, average age 66±11 years) with LBBB and without known CAD. All the pts had negative SECHO test according the Bruce protocol. Risk factors for CAD (diabetes, smoking, hypertension, high cholesterol and positive family history of CAD), Duke treadmill score, functional capacity (Metabolic Equivalents - METs) were recorded in all pts. Out of 224 pts, in 64 (29.5%) coronary flow reserve on the left anterior descending artery was assessed using pulsed Doppler echocardiography with adenosine in a dose of 140μcg/kg/body weight during 3 minutes. As the normal value we took value of CFR ≥2. Median follow up of the pts was 72 months (IQR 56.25–132 months) for the occurrence of MACE (cardiovascular death (CVD), non-fatal myocardial infarction (nfMI), coronary artery bypass graft (CABG) and percutaneous coronary revascularization (PCI). Results Out of 224 pts, 6 (2.7%) had positive SECHO test, 2 pts (0.9%) had died due to non-cardiac causes and 11 pts (4.9%) were lost to follow up so they were excluded from further analysis. The remaining 204 pts were divided in 2 groups: 1. pts with only negative SECHO (n=144, 68.8%); 2. pts with negative SECHO and normal CFR (n=64, 31.2%). During the follow-up period 22 out of 205 pts (10.7%) had an adverse event (6 CVD, 6 nfMI, 5 CABG, 8 PCI). Between the two groups there was no significant difference in risk factors and parameters of the SECHO test. Pts with CFR had significantly lower rate of MACE compared to the pts with only SECHO test (2, 3.1% vs 20, 14.2%, p=0.018, respectively). Using the Cox regression analysis, univariate predictors of MACE were insulin dependent diabetes (HR 10.851 [95% CI 2.095–56.220], p=0.004), Duke score (HR 0.603 [95% CI 0.414–0.878], p=0.008), and MET (HR 0.393 [95% CI 0.209–0.737], p=0.004). In the multivariate analysis only the insulin dependent diabetes remained an independent predictor of MACE (HR 6.906 [95% CI 1.100–43.363], p=0.039). Using the Kaplan-Meier survival curve we see that the pts with SECHO test and CFR had shorter event-free time compared to the pts with SECHO test (136.3±3.6 months vs 149.8±2.9 months, Log Rank 4.022, p=0.045) (Figure 1). Conclusion Normal value of CFR has good negative prognostic value in pts with LBBB without inducible ischemia and without known CAD, while pts with insulin dependent diabetes have more pronounced risk for the occurrence of adverse events. Funding Acknowledgement Type of funding sources: None.

Published
2022

2. Impact of diabetes on the management and outcomes in atrial fibrillation:an analysis from the ESC-EHRA EORP-AF Long-Term General Registry

Author

Wern Yew Ding, Agnieszka Kotalczyk, Giuseppe Boriani, Francisco Marin, Carina Blomström-Lundqvist, Tatjana S. Potpara, Laurent Fauchier, Gregory.Y.H. Lip, G. Boriani, G.Y.H. Lip, L. Tavazzi, A.P. Maggioni, G.-A. Dan, T. Potpara, M. Nabauer, F. Marin, Z. Kalarus, A. Goda, G. Mairesse, T. Shalganov, L. Antoniades, M. Taborsky, S. Riahi, P. Muda, I. García Bolao, O. Piot, K. Etsadashvili, E. Simantirakis, M. Haim, A. Azhari, J. Najafian, M. Santini, E. Mirrakhimov, K.A. Kulzida, A. Erglis, L. Poposka, M. Burg, H. Crijns, Ö. Erküner, D. Atar, R. Lenarczyk, M. Martins Oliveira, D. Shah, E. Serdechnaya, E. Diker, D. Lane, E. Zëra, U. Ekmekçiu, V. Paparisto, M. Tase, H. Gjergo, J. Dragoti, M. Ciutea, N. Ahadi, Z. el Husseini, M. Raepers, J. Leroy, P. Haushan, A. Jourdan, C. Lepiece, L. Desteghe, J. Vijgen, P. Koopman, G. Van Genechten, H. Heidbuchel, T. Boussy, M. De Coninck, H. Van Eeckhoutte, N. Bouckaert, A. Friart, J. Boreux, C. Arend, P. Evrard, L. Stefan, E. Hoffer, J. Herzet, M. Massoz, C. Celentano, M. Sprynger, L. Pierard, P. Melon, B. Van Hauwaert, C. Kuppens, D. Faes, D. Van Lier, A. Van Dorpe, A. Gerardy, O. Deceuninck, O. Xhaet, F. Dormal, E. Ballant, D. Blommaert, D. Yakova, M. Hristov, T. Yncheva, N. Stancheva, S. Tisheva, M. Tokmakova, F. Nikolov, D. Gencheva, B. Kunev, M. Stoyanov, D. Marchov, V. Gelev, V. Traykov, A. Kisheva, H. Tsvyatkov, R. Shtereva, S. Bakalska-Georgieva, S. Slavcheva, Y. Yotov, M. Kubíčková, A. Marni Joensen, A. Gammelmark, L. Hvilsted Rasmussen, P. Dinesen, S. Krogh Venø, B. Sorensen, A. Korsgaard, K. Andersen, C. Fragtrup Hellum, A. Svenningsen, O. Nyvad, P. Wiggers, O. May, A. Aarup, B. Graversen, L. Jensen, M. Andersen, M. Svejgaard, S. Vester, S. Hansen, V. Lynggaard, M. Ciudad, R. Vettus, A. Maestre, S. Castaño, S. Cheggour, J. Poulard, V. Mouquet, S. Leparrée, J. Bouet, J. Taieb, A. Doucy, H. Duquenne, A. Furber, J. Dupuis, J. Rautureau, M. Font, P. Damiano, M. Lacrimini, J. Abalea, S. Boismal, T. Menez, J. Mansourati, G. Range, H. Gorka, C. Laure, C. Vassalière, N. Elbaz, N. Lellouche, K. Djouadi, F. Roubille, D. Dietz, J. Davy, M. Granier, P. Winum, C. Leperchois-Jacquey, H. Kassim, E. Marijon, J. Le Heuzey, J. Fedida, C. Maupain, C. Himbert, E. Gandjbakhch, F. Hidden-Lucet, G. Duthoit, N. Badenco, T. Chastre, X. Waintraub, M. Oudihat, J. Lacoste, C. Stephan, H. Bader, N. Delarche, L. Giry, D. Arnaud, C. Lopez, F. Boury, I. Brunello, M. Lefèvre, R. Mingam, M. Haissaguerre, M. Le Bidan, D. Pavin, V. Le Moal, C. Leclercq, T. Beitar, I. Martel, A. Schmid, N. Sadki, C. Romeyer-Bouchard, A. Da Costa, I. Arnault, M. Boyer, C. Piat, N. Lozance, S. Nastevska, A. Doneva, B. Fortomaroska Milevska, B. Sheshoski, K. Petroska, N. Taneska, N. Bakrecheski, K. Lazarovska, S. Jovevska, V. Ristovski, A. Antovski, E. Lazarova, I. Kotlar, J. Taleski, S. Kedev, N. Zlatanovik, S. Jordanova, T. Bajraktarova Proseva, S. Doncovska, D. Maisuradze, A. Esakia, E. Sagirashvili, K. Lartsuliani, N. Natelashvili, N. Gumberidze, R. Gvenetadze, N. Gotonelia, N. Kuridze, G. Papiashvili, I. Menabde, S. Glöggler, A. Napp, C. Lebherz, H. Romero, K. Schmitz, M. Berger, M. Zink, S. Köster, J. Sachse, E. Vonderhagen, G. Soiron, K. Mischke, R. Reith, M. Schneider, W. Rieker, D. Boscher, A. Taschareck, A. Beer, D. Oster, O. Ritter, J. Adamczewski, S. Walter, A. Frommhold, E. Luckner, J. Richter, M. Schellner, S. Landgraf, S. Bartholome, R. Naumann, J. Schoeler, D. Westermeier, F. William, K. Wilhelm, M. Maerkl, R. Oekinghaus, M. Denart, M. Kriete, U. Tebbe, T. Scheibner, M. Gruber, A. Gerlach, C. Beckendorf, L. Anneken, M. Arnold, S. Lengerer, Z. Bal, C. Uecker, H. Förtsch, S. Fechner, V. Mages, E. Martens, H. Methe, T. Schmidt, B. Schaeffer, B. Hoffmann, J. Moser, K. Heitmann, S. Willems, C. Klaus, I. Lange, M. Durak, E. Esen, F. Mibach, H. Mibach, A. Utech, M. Gabelmann, R. Stumm, V. Ländle, C. Gartner, C. Goerg, N. Kaul, S. Messer, D. Burkhardt, C. Sander, R. Orthen, S. Kaes, A. Baumer, F. Dodos, A. Barth, G. Schaeffer, J. Gaertner, J. Winkler, A. Fahrig, J. Aring, I. Wenzel, S. Steiner, A. Kliesch, E. Kratz, K. Winter, P. Schneider, A. Haag, I. Mutscher, R. Bosch, J. Taggeselle, S. Meixner, A. Schnabel, A. Shamalla, H. Hötz, A. Korinth, C. Rheinert, G. Mehltretter, B. Schön, N. Schön, A. Starflinger, E. Englmann, G. Baytok, T. Laschinger, G. Ritscher, A. Gerth, D. Dechering, L. Eckardt, M. Kuhlmann, N. Proskynitopoulos, J. Brunn, K. Foth, C. Axthelm, H. Hohensee, K. Eberhard, S. Turbanisch, N. Hassler, A. Koestler, G. Stenzel, D. Kschiwan, M. Schwefer, S. Neiner, S. Hettwer, M. Haeussler-Schuchardt, R. Degenhardt, S. Sennhenn, M. Brendel, A. Stoehr, W. Widjaja, S. Loehndorf, A. Logemann, J. Hoskamp, J. Grundt, M. Block, R. Ulrych, A. Reithmeier, V. Panagopoulos, C. Martignani, D. Bernucci, E. Fantecchi, I. Diemberger, M. Ziacchi, M. Biffi, P. Cimaglia, J. Frisoni, I. Giannini, S. Boni, S. Fumagalli, S. Pupo, A. Di Chiara, P. Mirone, F. Pesce, C. Zoccali, V.L. Malavasi, A. Mussagaliyeva, B. Ahyt, Z. Salihova, K. Koshum-Bayeva, A. Kerimkulova, A. Bairamukova, B. Lurina, R. Zuzans, S. Jegere, I. Mintale, K. Kupics, K. Jubele, O. Kalejs, K. Vanhear, M. Cachia, E. Abela, S. Warwicker, T. Tabone, R. Xuereb, D. Asanovic, D. Drakalovic, M. Vukmirovic, N. Pavlovic, L. Music, N. Bulatovic, A. Boskovic, H. Uiterwaal, N. Bijsterveld, J. De Groot, J. Neefs, N. van den Berg, F. Piersma, A. Wilde, V. Hagens, J. Van Es, J. Van Opstal, B. Van Rennes, H. Verheij, W. Breukers, G. Tjeerdsma, R. Nijmeijer, D. Wegink, R. Binnema, S. Said, S. Philippens, W. van Doorn, T. Szili-Torok, R. Bhagwandien, P. Janse, A. Muskens, M. van Eck, R. Gevers, N. van der Ven, A. Duygun, B. Rahel, J. Meeder, A. Vold, C. Holst Hansen, I. Engset, B. Dyduch-Fejklowicz, E. Koba, M. Cichocka, A. Sokal, A. Kubicius, E. Pruchniewicz, A. Kowalik-Sztylc, W. Czapla, I. Mróz, M. Kozlowski, T. Pawlowski, M. Tendera, A. Winiarska-Filipek, A. Fidyk, A. Slowikowski, M. Haberka, M. Lachor-Broda, M. Biedron, Z. Gasior, M. Kołodziej, M. Janion, I. Gorczyca-Michta, B. Wozakowska-Kaplon, M. Stasiak, P. Jakubowski, T. Ciurus, J. Drozdz, M. Simiera, P. Zajac, T. Wcislo, P. Zycinski, J. Kasprzak, A. Olejnik, E. Harc-Dyl, J. Miarka, M. Pasieka, M. Ziemińska-Łuć, W. Bujak, A. Śliwiński, A. Grech, J. Morka, K. Petrykowska, M. Prasał, G. Hordyński, P. Feusette, P. Lipski, A. Wester, W. Streb, J. Romanek, P. Woźniak, M. Chlebuś, P. Szafarz, W. Stanik, M. Zakrzewski, J. Kaźmierczak, A. Przybylska, E. Skorek, H. Błaszczyk, M. Stępień, S. Szabowski, W. Krysiak, M. Szymańska, J. Karasiński, J. Blicharz, M. Skura, K. Hałas, L. Michalczyk, Z. Orski, K. Krzyżanowski, A. Skrobowski, L. Zieliński, M. Tomaszewska-Kiecana, M. Dłużniewski, M. Kiliszek, M. Peller, M. Budnik, P. Balsam, G. Opolski, A. Tymińska, K. Ozierański, A. Wancerz, A. Borowiec, E. Majos, R. Dabrowski, H. Szwed, A. Musialik-Lydka, A. Leopold-Jadczyk, E. Jedrzejczyk-Patej, M. Koziel, M. Mazurek, K. Krzemien-Wolska, P. Starosta, E. Nowalany-Kozielska, A. Orzechowska, M. Szpot, M. Staszel, S. Almeida, H. Pereira, L. Brandão Alves, R. Miranda, L. Ribeiro, F. Costa, F. Morgado, P. Carmo, P. Galvao Santos, R. Bernardo, P. Adragão, G. Ferreira da Silva, M. Peres, M. Alves, M. Leal, A. Cordeiro, P. Magalhães, P. Fontes, S. Leão, A. Delgado, A. Costa, B. Marmelo, B. Rodrigues, D. Moreira, J. Santos, L. Santos, A. Terchet, D. Darabantiu, S. Mercea, V. Turcin Halka, A. Pop Moldovan, A. Gabor, B. Doka, G. Catanescu, H. Rus, L. Oboroceanu, E. Bobescu, R. Popescu, A. Dan, A. Buzea, I. Daha, G. Dan, I. Neuhoff, M. Baluta, R. Ploesteanu, N. Dumitrache, M. Vintila, A. Daraban, C. Japie, E. Badila, H. Tewelde, M. Hostiuc, S. Frunza, E. Tintea, D. Bartos, A. Ciobanu, I. Popescu, N. Toma, C. Gherghinescu, D. Cretu, N. Patrascu, C. Stoicescu, C. Udroiu, G. Bicescu, V. Vintila, D. Vinereanu, M. Cinteza, R. Rimbas, M. Grecu, A. Cozma, F. Boros, M. Ille, O. Tica, R. Tor, A. Corina, A. Jeewooth, B. Maria, C. Georgiana, C. Natalia, D. Alin, D. Dinu-Andrei, M. Livia, R. Daniela, R. Larisa, S. Umaar, T. Tamara, M. Ioachim Popescu, D. Nistor, I. Sus, O. Coborosanu, N. Alina-Ramona, R. Dan, L. Petrescu, G. Ionescu, C. Vacarescu, E. Goanta, M. Mangea, A. Ionac, C. Mornos, D. Cozma, S. Pescariu, E. Solodovnicova, I. Soldatova, J. Shutova, L. Tjuleneva, T. Zubova, V. Uskov, D. Obukhov, G. Rusanova, N. Isakova, S. Odinsova, T. Arhipova, E. Kazakevich, O. Zavyalova, T. Novikova, I. Riabaia, S. Zhigalov, E. Drozdova, I. Luchkina, Y. Monogarova, D. Hegya, L. Rodionova, V. Nevzorova, O. Lusanova, A. Arandjelovic, D. Toncev, L. Vukmirovic, M. Radisavljevic, M. Milanov, N. Sekularac, M. Zdravkovic, S. Hinic, S. Dimkovic, T. Acimovic, J. Saric, S. Radovanovic, A. Kocijancic, B. Obrenovic-Kircanski, D. Kalimanovska Ostric, D. Simic, I. Jovanovic, I. Petrovic, M. Polovina, M. Vukicevic, M. Tomasevic, N. Mujovic, N. Radivojevic, O. Petrovic, S. Aleksandric, V. Kovacevic, Z. Mijatovic, B. Ivanovic, M. Tesic, A. Ristic, B. Vujisic-Tesic, M. Nedeljkovic, A. Karadzic, A. Uscumlic, M. Prodanovic, M. Zlatar, M. Asanin, B. Bisenic, V. Vasic, Z. Popovic, D. Djikic, M. Sipic, V. Peric, B. Dejanovic, N. Milosevic, S. Backovic, A. Stevanovic, A. Andric, B. Pencic, M. Pavlovic-Kleut, V. Celic, M. Pavlovic, M. Petrovic, M. Vuleta, N. Petrovic, S. Simovic, Z. Savovic, S. Milanov, G. Davidovic, V. Iric-Cupic, D. Djordjevic, M. Damjanovic, S. Zdravkovic, V. Topic, D. Stanojevic, M. Randjelovic, R. Jankovic-Tomasevic, V. Atanaskovic, S. Antic, D. Simonovic, M. Stojanovic, S. Stojanovic, V. Mitic, V. Ilic, D. Petrovic, M. Deljanin Ilic, S. Ilic, V. Stoickov, S. Markovic, A. Mijatovic, D. Tanasic, G. Radakovic, J. Peranovic, N. Panic-Jelic, O. Vujadinovic, P. Pajic, S. Bekic, S. Kovacevic, A. García Fernandez, A. Perez Cabeza, M. Anguita, L. Tercedor Sanchez, E. Mau, J. Loayssa, M. Ayarra, M. Carpintero, I. Roldán Rabadan, M. Gil Ortega, A. Tello Montoliu, E. Orenes Piñero, S. Manzano Fernández, F. Marín, A. Romero Aniorte, A. Veliz Martínez, M. Quintana Giner, G. Ballesteros, M. Palacio, O. Alcalde, I. García-Bolao, V. Bertomeu Gonzalez, F. Otero-Raviña, J. García Seara, J. Gonzalez Juanatey, N. Dayal, P. Maziarski, P. Gentil-Baron, M. Koç, E. Onrat, I.E. Dural, K. Yilmaz, B. Özin, S. Tan Kurklu, Y. Atmaca, U. Canpolat, L. Tokgozoglu, A.K. Dolu, B. Demirtas, D. Sahin, O. Ozcan Celebi, G. Gagirci, U.O. Turk, H. Ari, N. Polat, N. Toprak, M. Sucu, O. Akin Serdar, A. Taha Alper, A. Kepez, Y. Yuksel, A. Uzunselvi, S. Yuksel, M. Sahin, O. Kayapinar, T. Ozcan, H. Kaya, M.B. Yilmaz, M. Kutlu, M. Demir, C. Gibbs, S. Kaminskiene, M. Bryce, A. Skinner, G. Belcher, J. Hunt, L. Stancombe, B. Holbrook, C. Peters, S. Tettersell, A. Shantsila, K. Senoo, M. Proietti, K. Russell, P. Domingos, S. Hussain, J. Partridge, R. Haynes, S. Bahadur, R. Brown, S. McMahon, J. McDonald, K. Balachandran, R. Singh, S. Garg, H. Desai, K. Davies, W. Goddard, G. Galasko, I. Rahman, Y. Chua, O. Payne, S. Preston, O. Brennan, L. Pedley, C. Whiteside, C. Dickinson, J. Brown, K. Jones, L. Benham, R. Brady, L. Buchanan, A. Ashton, H. Crowther, H. Fairlamb, S. Thornthwaite, C. Relph, A. McSkeane, U. Poultney, N. Kelsall, P. Rice, T. Wilson, M. Wrigley, R. Kaba, T. Patel, E. Young, J. Law, C. Runnett, H. Thomas, H. McKie, J. Fuller, S. Pick, A. Sharp, A. Hunt, K. Thorpe, C. Hardman, E. Cusack, L. Adams, M. Hough, S. Keenan, A. Bowring, J. Watts, J. Zaman, K. Goffin, H. Nutt, Y. Beerachee, J. Featherstone, C. Mills, J. Pearson, L. Stephenson, S. Grant, A. Wilson, C. Hawksworth, I. Alam, M. Robinson, S. Ryan, R. Egdell, E. Gibson, M. Holland, D. Leonard, B. Mishra, S. Ahmad, H. Randall, J. Hill, L. Reid, M. George, S. McKinley, L. Brockway, W. Milligan, J. Sobolewska, J. Muir, L. Tuckis, L. Winstanley, P. Jacob, S. Kaye, L. Morby, A. Jan, T. Sewell, C. Boos, B. Wadams, C. Cope, P. Jefferey, N. Andrews, A. Getty, A. Suttling, C. Turner, K. Hudson, R. Austin, S. Howe, R. Iqbal, N. Gandhi, K. Brophy, P. Mirza, E. Willard, S. Collins, N. Ndlovu, E. Subkovas, V. Karthikeyan, L. Waggett, A. Wood, A. Bolger, J. Stockport, L. Evans, E. Harman, J. Starling, L. Williams, V. Saul, M. Sinha, L. Bell, S. Tudgay, S. Kemp, L. Frost, T. Ingram, A. Loughlin, C. Adams, M. Adams, F. Hurford, C. Owen, C. Miller, D. Donaldson, H. Tivenan, H. Button, A. Nasser, O. Jhagra, B. Stidolph, C. Brown, C. Livingstone, M. Duffy, P. Madgwick, P. Roberts, E. Greenwood, L. Fletcher, M. Beveridge, S. Earles, D. McKenzie, D. Beacock, M. Dayer, M. Seddon, D. Greenwell, F. Luxton, F. Venn, H. Mills, J. Rewbury, K. James, K. Roberts, L. Tonks, D. Felmeden, W. Taggu, A. Summerhayes, D. Hughes, J. Sutton, L. Felmeden, M. Khan, E. Walker, L. Norris, L. O'Donohoe, A. Mozid, H. Dymond, H. Lloyd-Jones, G. Saunders, D. Simmons, D. Coles, D. Cotterill, S. Beech, S. Kidd, B. Wrigley, S. Petkar, A. Smallwood, R. Jones, E. Radford, S. Milgate, S. Metherell, V. Cottam, C. Buckley, A. Broadley, D. Wood, J. Allison, K. Rennie, L. Balian, L. Howard, L. Pippard, S. Board, T. Pitt-Kerby, Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Océan du Large et Variabilité Climatique (OLVAC), Laboratoire d'études en Géophysique et océanographie spatiales (LEGOS), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Uppsala University, University of Belgrade [Belgrade], CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Éducation Éthique Santé EA 7505 (EES), and Université de Tours (UT)

Subjects
Kardiologi, General Practice, Cohort, Anticoagulants, MACE, Endocrinology and Diabetes, Prognosis, [SHS]Humanities and Social Sciences, Allmänmedicin, Stroke, Risk Factors, Healthcare resource utilisation, Mortality, Prevalence, Endokrinologi och diabetes, Atrial Fibrillation, Internal Medicine, Diabetes Mellitus, Quality of Life, Humans, Cardiac and Cardiovascular Systems, Prospective Studies, Registries, Aged
Abstract

BACKGROUND: The prevalence of atrial fibrillation(AF) and diabetes mellitus is rising to epidemic proportions. We aimed to assess the impact of diabetes on the management and outcomes of patients with AF.METHODS: The EORP-AF General Long-Term Registry is a prospective, observational registry from 250 centres across 27 European countries. Outcomes of interest were as follows: i)rhythm control interventions; ii)quality of life; iii)healthcare resource utilisation; and iv)major adverse events.RESULTS: Of 11,028 patients with AF, the median age was 71 (63-77) years and 2537 (23.0%) had diabetes. Median follow-up was 24 months. Diabetes was related to increased use of anticoagulation but less rhythm control interventions. Using multivariable analysis, at 2-year follow-up, patients with diabetes were associated with greater levels of anxiety (p = 0.038) compared to those without diabetes. Overall, diabetes was associated with worse health during follow-up, as indicated by Health Utility Score and Visual Analogue Scale. Healthcare resource utilisation was greater with diabetes in terms of length of hospital stay (8.1 (±8.2) vs. 6.1 (±6.7) days); cardiology and internal medicine/general practitioner visits; and emergency room admissions. Diabetes was an independent risk factor of major adverse cardiovascular event (MACE; HR 1.26 [95% CI, 1.04-1.52]), all-cause mortality (HR 1.28 [95% CI, 1.08-1.52]), and cardiovascular mortality (HR 1.41 [95% CI, 1.09-1.83]).CONCLUSION: In this contemporary AF cohort, diabetes was present in 1 in 4 patients and it served as an independent risk factor for reduced quality of life, greater healthcare resource utilisation and excess MACE, all-cause mortality and cardiovascular mortality. There was increased use of anticoagulation therapy in diabetes but with less rhythm control interventions.

Published
2022

3. Cardiac troponins and adverse outcomes in European patients with atrial fibrillation: A report from the ESC-EHRA EORP atrial fibrillation general long-term registry

Author

Marco Vitolo, Vincenzo L. Malavasi, Marco Proietti, Igor Diemberger, Laurent Fauchier, Francisco Marin, Michael Nabauer, Tatjana S. Potpara, Gheorghe-Andrei Dan, Zbigniew Kalarus, Luigi Tavazzi, Aldo Pietro Maggioni, Deirdre A. Lane, Gregory Y.H. Lip, Giuseppe Boriani, G. Boriani, G.Y.H. Lip, L. Tavazzi, A.P. Maggioni, G-A. Dan, T. Potpara, M. Nabauer, F. Marin, Z. Kalarus, L. Fauchier, A. Goda, G. Mairesse, T. Shalganov, L. Antoniades, M. Taborsky, S. Riahi, P. Muda, I. García Bolao, O. Piot, K. Etsadashvili, M. Haim, A. Azhari, J. Najafian, M. Santini, E. Mirrakhimov, K. Kulzida, A. Erglis, L. Poposka, M.R. Burg, H. Crijns, Ö. Erküner, D. Atar, R. Lenarczyk, M. Martins Oliveira, D. Shah, E. Serdechnaya, E. Diker, E. Zëra, U. Ekmekçiu, V. Paparisto, M. Tase, H. Gjergo, J. Dragoti, M. Ciutea, N. Ahadi, Z. el Husseini, M. Raepers, J. Leroy, P. Haushan, A. Jourdan, C. Lepiece, L. Desteghe, J. Vijgen, P. Koopman, G. Van Genechten, H. Heidbuchel, T. Boussy, M. De Coninck, H. Van Eeckhoutte, N. Bouckaert, A. Friart, J. Boreux, C. Arend, P. Evrard, L. Stefan, E. Hoffer, J. Herzet, M. Massoz, C. Celentano, M. Sprynger, L. Pierard, P. Melon, B. Van Hauwaert, C. Kuppens, D. Faes, D. Van Lier, A. Van Dorpe, A. Gerardy, O. Deceuninck, O. Xhaet, F. Dormal, E. Ballant, D. Blommaert, D. Yakova, M. Hristov, T. Yncheva, N. Stancheva, S. Tisheva, M. Tokmakova, F. Nikolov, D. Gencheva, B. Kunev, M. Stoyanov, D. Marchov, V. Gelev, V. Traykov, A. Kisheva, H. Tsvyatkov, R. Shtereva, S. Bakalska-Georgieva, S. Slavcheva, Y. Yotov, M. Kubíčková, A. Marni Joensen, A. Gammelmark, L. Hvilsted Rasmussen, P. Dinesen, S. Krogh Venø, B. Sorensen, A. Korsgaard, K. Andersen, C. Fragtrup Hellum, A. Svenningsen, O. Nyvad, P. Wiggers, O. May, A. Aarup, B. Graversen, L. Jensen, M. Andersen, M. Svejgaard, S. Vester, S. Hansen, V. Lynggaard, M. Ciudad, R. Vettus, A. Maestre, S. Castaño, S. Cheggour, J. Poulard, V. Mouquet, S. Leparrée, J. Bouet, J. Taieb, A. Doucy, H. Duquenne, A. Furber, J. Dupuis, J. Rautureau, M. Font, P. Damiano, M. Lacrimini, J. Abalea, S. Boismal, T. Menez, J. Mansourati, G. Range, H. Gorka, C. Laure, C. Vassalière, N. Elbaz, N. Lellouche, K. Djouadi, F. Roubille, D. Dietz, J. Davy, M. Granier, P. Winum, C. Leperchois-Jacquey, H. Kassim, E. Marijon, J. Le Heuzey, J. Fedida, C. Maupain, C. Himbert, E. Gandjbakhch, F. Hidden-Lucet, G. Duthoit, N. Badenco, T. Chastre, X. Waintraub, M. Oudihat, J. Lacoste, C. Stephan, H. Bader, N. Delarche, L. Giry, D. Arnaud, C. Lopez, F. Boury, I. Brunello, M. Lefèvre, R. Mingam, M. Haissaguerre, M. Le Bidan, D. Pavin, V. Le Moal, C. Leclercq, T. Beitar, I. Martel, A. Schmid, N. Sadki, C. Romeyer-Bouchard, A. Da Costa, I. Arnault, M. Boyer, C. Piat, N. Lozance, S. Nastevska, A. Doneva, B. Fortomaroska Milevska, B. Sheshoski, K. Petroska, N. Taneska, N. Bakrecheski, K. Lazarovska, S. Jovevska, V. Ristovski, A. Antovski, E. Lazarova, I. Kotlar, J. Taleski, S. Kedev, N. Zlatanovik, S. Jordanova, T. Bajraktarova Proseva, S. Doncovska, D. Maisuradze, A. Esakia, E. Sagirashvili, K. Lartsuliani, N. Natelashvili, N. Gumberidze, R. Gvenetadze, N. Gotonelia, N. Kuridze, G. Papiashvili, I. Menabde, S. Glöggler, A. Napp, C. Lebherz, H. Romero, K. Schmitz, M. Berger, M. Zink, S. Köster, J. Sachse, E. Vonderhagen, G. Soiron, K. Mischke, R. Reith, M. Schneider, W. Rieker, D. Boscher, A. Taschareck, A. Beer, D. Oster, O. Ritter, J. Adamczewski, S. Walter, A. Frommhold, E. Luckner, J. Richter, M. Schellner, S. Landgraf, S. Bartholome, R. Naumann, J. Schoeler, D. Westermeier, F. William, K. Wilhelm, M. Maerkl, R. Oekinghaus, M. Denart, M. Kriete, U. Tebbe, T. Scheibner, M. Gruber, A. Gerlach, C. Beckendorf, L. Anneken, M. Arnold, S. Lengerer, Z. Bal, C. Uecker, H. Förtsch, S. Fechner, V. Mages, E. Martens, H. Methe, T. Schmidt, B. Schaeffer, B. Hoffmann, J. Moser, K. Heitmann, S. Willems, C. Klaus, I. Lange, M. Durak, E. Esen, F. Mibach, H. Mibach, A. Utech, M. Gabelmann, R. Stumm, V. Ländle, C. Gartner, C. Goerg, N. Kaul, S. Messer, D. Burkhardt, C. Sander, R. Orthen, S. Kaes, A. Baumer, F. Dodos, A. Barth, G. Schaeffer, J. Gaertner, J. Winkler, A. Fahrig, J. Aring, I. Wenzel, S. Steiner, A. Kliesch, E. Kratz, K. Winter, P. Schneider, A. Haag, I. Mutscher, R. Bosch, J. Taggeselle, S. Meixner, A. Schnabel, A. Shamalla, H. Hötz, A. Korinth, C. Rheinert, G. Mehltretter, B. Schön, N. Schön, A. Starflinger, E. Englmann, G. Baytok, T. Laschinger, G. Ritscher, A. Gerth, D. Dechering, L. Eckardt, M. Kuhlmann, N. Proskynitopoulos, J. Brunn, K. Foth, C. Axthelm, H. Hohensee, K. Eberhard, S. Turbanisch, N. Hassler, A. Koestler, G. Stenzel, D. Kschiwan, M. Schwefer, S. Neiner, S. Hettwer, M. Haeussler-Schuchardt, R. Degenhardt, S. Sennhenn, M. Brendel, A. Stoehr, W. Widjaja, S. Loehndorf, A. Logemann, J. Hoskamp, J. Grundt, M. Block, R. Ulrych, A. Reithmeier, V. Panagopoulos, C. Martignani, D. Bernucci, E. Fantecchi, I. Diemberger, M. Ziacchi, M. Biffi, P. Cimaglia, J. Frisoni, I. Giannini, S. Boni, S. Fumagalli, S. Pupo, A. Di Chiara, P. Mirone, F. Pesce, C. Zoccali, V.L. Malavasi, A. Mussagaliyeva, B. Ahyt, Z. Salihova, K. Koshum-Bayeva, A. Kerimkulova, A. Bairamukova, B. Lurina, R. Zuzans, S. Jegere, I. Mintale, K. Kupics, K. Jubele, O. Kalejs, K. Vanhear, M. Burg, M. Cachia, E. Abela, S. Warwicker, T. Tabone, R. Xuereb, D. Asanovic, D. Drakalovic, M. Vukmirovic, N. Pavlovic, L. Music, N. Bulatovic, A. Boskovic, H. Uiterwaal, N. Bijsterveld, J. De Groot, J. Neefs, N. van den Berg, F. Piersma, A. Wilde, V. Hagens, J. Van Es, J. Van Opstal, B. Van Rennes, H. Verheij, W. Breukers, G. Tjeerdsma, R. Nijmeijer, D. Wegink, R. Binnema, S. Said, S. Philippens, W. van Doorn, T. Szili-Torok, R. Bhagwandien, P. Janse, A. Muskens, M. van Eck, R. Gevers, N. van der Ven, A. Duygun, B. Rahel, J. Meeder, A. Vold, C. Holst Hansen, I. Engset, B. Dyduch-Fejklowicz, E. Koba, M. Cichocka, A. Sokal, A. Kubicius, E. Pruchniewicz, A. Kowalik-Sztylc, W. Czapla, I. Mróz, M. Kozlowski, T. Pawlowski, M. Tendera, A. Winiarska-Filipek, A. Fidyk, A. Slowikowski, M. Haberka, M. Lachor-Broda, M. Biedron, Z. Gasior, M. Kołodziej, M. Janion, I. Gorczyca-Michta, B. Wozakowska-Kaplon, M. Stasiak, P. Jakubowski, T. Ciurus, J. Drozdz, M. Simiera, P. Zajac, T. Wcislo, P. Zycinski, J. Kasprzak, A. Olejnik, E. Harc-Dyl, J. Miarka, M. Pasieka, M. Ziemińska-Łuć, W. Bujak, A. Śliwiński, A. Grech, J. Morka, K. Petrykowska, M. Prasał, G. Hordyński, P. Feusette, P. Lipski, A. Wester, W. Streb, J. Romanek, P. Woźniak, M. Chlebuś, P. Szafarz, W. Stanik, M. Zakrzewski, J. Kaźmierczak, A. Przybylska, E. Skorek, H. Błaszczyk, M. Stępień, S. Szabowski, W. Krysiak, M. Szymańska, J. Karasiński, J. Blicharz, M. Skura, K. Hałas, L. Michalczyk, Z. Orski, K. Krzyżanowski, A. Skrobowski, L. Zieliński, M. Tomaszewska-Kiecana, M. Dłużniewski, M. Kiliszek, M. Peller, M. Budnik, P. Balsam, G. Opolski, A. Tymińska, K. Ozierański, A. Wancerz, A. Borowiec, E. Majos, R. Dabrowski, H. Szwed, A. Musialik-Lydka, A. Leopold-Jadczyk, E. Jedrzejczyk-Patej, M. Koziel, M. Mazurek, K. Krzemien-Wolska, P. Starosta, E. Nowalany-Kozielska, A. Orzechowska, M. Szpot, M. Staszel, S. Almeida, H. Pereira, L. Brandão Alves, R. Miranda, L. Ribeiro, F. Costa, F. Morgado, P. Carmo, P. Galvao Santos, R. Bernardo, P. Adragão, G. Ferreira da Silva, M. Peres, M. Alves, M. Leal, A. Cordeiro, P. Magalhães, P. Fontes, S. Leão, A. Delgado, A. Costa, B. Marmelo, B. Rodrigues, D. Moreira, J. Santos, L. Santos, A. Terchet, D. Darabantiu, S. Mercea, V. Turcin Halka, A. Pop Moldovan, A. Gabor, B. Doka, G. Catanescu, H. Rus, L. Oboroceanu, E. Bobescu, R. Popescu, A. Dan, A. Buzea, I. Daha, G. Dan, I. Neuhoff, M. Baluta, R. Ploesteanu, N. Dumitrache, M. Vintila, A. Daraban, C. Japie, E. Badila, H. Tewelde, M. Hostiuc, S. Frunza, E. Tintea, D. Bartos, A. Ciobanu, I. Popescu, N. Toma, C. Gherghinescu, D. Cretu, N. Patrascu, C. Stoicescu, C. Udroiu, G. Bicescu, V. Vintila, D. Vinereanu, M. Cinteza, R. Rimbas, M. Grecu, A. Cozma, F. Boros, M. Ille, O. Tica, R. Tor, A. Corina, A. Jeewooth, B. Maria, C. Georgiana, C. Natalia, D. Alin, D. Dinu-Andrei, M. Livia, R. Daniela, R. Larisa, S. Umaar, T. Tamara, M. Ioachim Popescu, D. Nistor, I. Sus, O. Coborosanu, N. Alina-Ramona, R. Dan, L. Petrescu, G. Ionescu, C. Vacarescu, E. Goanta, M. Mangea, A. Ionac, C. Mornos, D. Cozma, S. Pescariu, E. Solodovnicova, I. Soldatova, J. Shutova, L. Tjuleneva, T. Zubova, V. Uskov, D. Obukhov, G. Rusanova, N. Isakova, S. Odinsova, T. Arhipova, E. Kazakevich, O. Zavyalova, T. Novikova, I. Riabaia, S. Zhigalov, E. Drozdova, I. Luchkina, Y. Monogarova, D. Hegya, L. Rodionova, V. Nevzorova, O. Lusanova, A. Arandjelovic, D. Toncev, L. Vukmirovic, M. Radisavljevic, M. Milanov, N. Sekularac, M. Zdravkovic, S. Hinic, S. Dimkovic, T. Acimovic, J. Saric, S. Radovanovic, A. Kocijancic, B. Obrenovic-Kircanski, D. Kalimanovska Ostric, D. Simic, I. Jovanovic, I. Petrovic, M. Polovina, M. Vukicevic, M. Tomasevic, N. Mujovic, N. Radivojevic, O. Petrovic, S. Aleksandric, V. Kovacevic, Z. Mijatovic, B. Ivanovic, M. Tesic, A. Ristic, B. Vujisic-Tesic, M. Nedeljkovic, A. Karadzic, A. Uscumlic, M. Prodanovic, M. Zlatar, M. Asanin, B. Bisenic, V. Vasic, Z. Popovic, D. Djikic, M. Sipic, V. Peric, B. Dejanovic, N. Milosevic, S. Backovic, A. Stevanovic, A. Andric, B. Pencic, M. Pavlovic-Kleut, V. Celic, M. Pavlovic, M. Petrovic, M. Vuleta, N. Petrovic, S. Simovic, Z. Savovic, S. Milanov, G. Davidovic, V. Iric-Cupic, D. Djordjevic, M. Damjanovic, S. Zdravkovic, V. Topic, D. Stanojevic, M. Randjelovic, R. Jankovic-Tomasevic, V. Atanaskovic, S. Antic, D. Simonovic, M. Stojanovic, S. Stojanovic, V. Mitic, V. Ilic, D. Petrovic, M. Deljanin Ilic, S. Ilic, V. Stoickov, S. Markovic, A. Mijatovic, D. Tanasic, G. Radakovic, J. Peranovic, N. Panic-Jelic, O. Vujadinovic, P. Pajic, S. Bekic, S. Kovacevic, A. García Fernandez, A. Perez Cabeza, M. Anguita, L. Tercedor Sanchez, E. Mau, J. Loayssa, M. Ayarra, M. Carpintero, I. Roldán Rabadan, M. Gil Ortega, A. Tello Montoliu, E. Orenes Piñero, S. Manzano Fernández, F. Marín, A. Romero Aniorte, A. Veliz Martínez, M. Quintana Giner, G. Ballesteros, M. Palacio, O. Alcalde, I. García-Bolao, V. Bertomeu Gonzalez, F. Otero-Raviña, J. García Seara, J. Gonzalez Juanatey, N. Dayal, P. Maziarski, P. Gentil-Baron, M. Koç, E. Onrat, I.E. Dural, K. Yilmaz, B. Özin, S. Tan Kurklu, Y. Atmaca, U. Canpolat, L. Tokgozoglu, A.K. Dolu, B. Demirtas, D. Sahin, O. Ozcan Celebi, G. Gagirci, U.O. Turk, H. Ari, N. Polat, N. Toprak, M. Sucu, O. Akin Serdar, A. Taha Alper, A. Kepez, Y. Yuksel, A. Uzunselvi, S. Yuksel, M. Sahin, O. Kayapinar, T. Ozcan, H. Kaya, M.B. Yilmaz, M. Kutlu, M. Demir, C. Gibbs, S. Kaminskiene, M. Bryce, A. Skinner, G. Belcher, J. Hunt, L. Stancombe, B. Holbrook, C. Peters, S. Tettersell, A. Shantsila, D. Lane, K. Senoo, M. Proietti, K. Russell, P. Domingos, S. Hussain, J. Partridge, R. Haynes, S. Bahadur, R. Brown, S. McMahon, J. McDonald, K. Balachandran, R. Singh, S. Garg, H. Desai, K. Davies, W. Goddard, G. Galasko, I. Rahman, Y. Chua, O. Payne, S. Preston, O. Brennan, L. Pedley, C. Whiteside, C. Dickinson, J. Brown, K. Jones, L. Benham, R. Brady, L. Buchanan, A. Ashton, H. Crowther, H. Fairlamb, S. Thornthwaite, C. Relph, A. McSkeane, U. Poultney, N. Kelsall, P. Rice, T. Wilson, M. Wrigley, R. Kaba, T. Patel, E. Young, J. Law, C. Runnett, H. Thomas, H. McKie, J. Fuller, S. Pick, A. Sharp, A. Hunt, K. Thorpe, C. Hardman, E. Cusack, L. Adams, M. Hough, S. Keenan, A. Bowring, J. Watts, J. Zaman, K. Goffin, H. Nutt, Y. Beerachee, J. Featherstone, C. Mills, J. Pearson, L. Stephenson, S. Grant, A. Wilson, C. Hawksworth, I. Alam, M. Robinson, S. Ryan, R. Egdell, E. Gibson, M. Holland, D. Leonard, B. Mishra, S. Ahmad, H. Randall, J. Hill, L. Reid, M. George, S. McKinley, L. Brockway, W. Milligan, J. Sobolewska, J. Muir, L. Tuckis, L. Winstanley, P. Jacob, S. Kaye, L. Morby, A. Jan, T. Sewell, C. Boos, B. Wadams, C. Cope, P. Jefferey, N. Andrews, A. Getty, A. Suttling, C. Turner, K. Hudson, R. Austin, S. Howe, R. Iqbal, N. Gandhi, K. Brophy, P. Mirza, E. Willard, S. Collins, N. Ndlovu, E. Subkovas, V. Karthikeyan, L. Waggett, A. Wood, A. Bolger, J. Stockport, L. Evans, E. Harman, J. Starling, L. Williams, V. Saul, M. Sinha, L. Bell, S. Tudgay, S. Kemp, L. Frost, T. Ingram, A. Loughlin, C. Adams, M. Adams, F. Hurford, C. Owen, C. Miller, D. Donaldson, H. Tivenan, H. Button, A. Nasser, O. Jhagra, B. Stidolph, C. Brown, C. Livingstone, M. Duffy, P. Madgwick, P. Roberts, E. Greenwood, L. Fletcher, M. Beveridge, S. Earles, D. McKenzie, D. Beacock, M. Dayer, M. Seddon, D. Greenwell, F. Luxton, F. Venn, H. Mills, J. Rewbury, K. James, K. Roberts, L. Tonks, D. Felmeden, W. Taggu, A. Summerhayes, D. Hughes, J. Sutton, L. Felmeden, M. Khan, E. Walker, L. Norris, L. O'Donohoe, A. Mozid, H. Dymond, H. Lloyd-Jones, G. Saunders, D. Simmons, D. Coles, D. Cotterill, S. Beech, S. Kidd, B. Wrigley, S. Petkar, A. Smallwood, R. Jones, E. Radford, S. Milgate, S. Metherell, V. Cottam, C. Buckley, A. Broadley, D. Wood, J. Allison, K. Rennie, L. Balian, L. Howard, L. Pippard, S. Board, and T. Pitt-Kerby

Subjects
Male, AF registry, Atrial fibrillation, Biomarkers, Death, Major adverse cardiovascular events, outcomes, Troponins, Troponin, Risk Factors, Atrial Fibrillation, Internal Medicine, Humans, Female, Prospective Studies, Registries, Aged
Abstract

BACKGROUND: Cardiac troponins (cTn) have been reported to be predictors for adverse outcomes in atrial fibrillation (AF), patients, but their actual use is still unclear.AIM: To assess the factors associated with cTn testing in routine practice and evaluate the association with outcomes.METHODS: Patients enrolled in the ESC-EHRA EORP-AF General Long-Term Registry were stratified into 3 groups according to cTn levels as (i) cTn not tested, (ii) cTn in range (≤99th percentile), (iii) cTn elevated (>99th percentile). The composite outcome of any thromboembolism /any acute coronary syndrome/cardiovascular (CV) death, defined as Major Adverse Cardiovascular Events (MACE) and all-cause death were the main endpoints.RESULTS: Among 10 445 AF patients (median age 71 years, 40.3% females) cTn were tested in 2834 (27.1%). cTn was elevated in 904/2834 (31.9%) and in-range in 1930/2834 (68.1%) patients. Female sex, in-hospital enrollment, first-detected AF, CV risk factors, history of coronary artery disease, and atypical AF symptoms were independently associated with cTn testing. Elevated cTn were independently associated with a higher risk for MACE (Model 1, hazard ratio [HR] 1.74, 95% confidence interval [CI] 1.40-2.16, Model 2, HR 1.62, 95% CI 1.28-2.05; Model 3 HR 1.76, 95% CI 1.37-2.26) and all-cause death (Model 1, HR 1.45, 95% CI 1.21-1.74; Model 2, HR 1.36, 95% CI 1.12-1.66; Model 3, HR 1.38, 95% CI 1.12-1.71).CONCLUSIONS: Elevated cTn levels were associated with an increased risk of all-cause mortality and adverse CV events. Clinical factors that might enhance the need to rule out CAD were associated with cTn testing.

Published
2022

5. Clinical Case Poster session 4P1046An unexpected findingP1047Coronary artery ectasia in the setting of subacute Inferior STEMIP1048Diagnosis through the back door: the utility of the subscapular acoustic windowP1049A challenging case of paravalvular leakage closureP1050A life-threatning asymptomatic incidental findingP1051Acute heart failure due to intermittent aortic prosthesis regurgitation - case reportP1052Role of echocardiography in a patient with sequels after surgical treatment of infective endocarditis on a bicuspid aortic valveP1053MitraClip to treat systolic anterior motion-induced outflow tract obstruction in hypertrophic obstructive cardiomyopathyP1054Acute heart failure by parvovirus B19P1055Multimodality assessment of myocardial involvement in female carriers of the Duchenne diseaseP1056Cardiovascular complications in hypereosinophilic syndrom-a case reportP1057Giant false left ventricle aneurysm in the myocardial infarction outcomeP1058From syncope to the diagnosis of systemic disease: the importance of a high index of suspicionP1059A total anomalous pulmonary venous return in 60-year-old patientP1060Atrial septal defect occluder fracture - diagnostic challenge in asymptomatic patientP1061Marfan syndrome in two newborn infantsP1062Isolated pulmonary valve regurgitation as a cause of severe right heart dilatation in an adult patientP1063Multimodality imaging - how to find the missing leak

Author

F. Valente, I. Cazzoli, T. Jurko, AC. Gomes, A. Wojtkowska, M. Chivulescu, A. Namitokov, C. Stefan, JJ. Portero Portaz, A. Nunes, AG. Pavon, K. Andjelkovic, G. Neves Pestana, MJV Maria Joao Vieira, CY. Wong, G. Giannakopoulos, E. Cambronero Cortinas, R. Ilhao Moreira, L. Moura Branco, M. Coutinho Cruz, P. Pinto Teixeira, L. Almeida Morais, A. Viveiros Monteiro, M. Oliveira, R. Ramos, A. Agapito, R. Cruz Ferreira, P. Racugno, D. Escribano, J. Mendez, A. Paya, C. Bonanad, A. Valle Munoz, MJ. Corbi Pascual, FJ. Chorro, V. Bodi, H. Mueller, CC. Catia Costa, BSS Beatriz Saldanha Santos, KD. Kevin Domingues, NC. Nuno Craveiro, MLP Maria Luz Pitta, MA. Miguel Alves, ML. Margarida Leal, P. Bernardo-Almeida, C. Sousa, M. Tavares-Silva, R. Almeida, R. Lima, MJ. Amorim, J. Almeida, F. Macedo, MJ. Maciel, D. Kalimanovska Ostric, M. Boricic Kostic, O. Petrovic, M. Petrovic, B. Vujisic Tesic, A. Mikic, A. Kalangos, C. Marini, I. Rosa, S. Stella, F. Ancona, M. Spartera, A. Margonato, A. Colombo, E. Agricola, H. Nascimento, P. Maia Araujo, A. Ferreira, T. Pinho, R. Andre Rodrigues, P. Bernardo Almeida, M. Campelo, P. Dias, M. Julia Maciel, A. Tercero Martinez, D. Prieto Mateos, C. Urraca Espejel, S. Calero Nunez, R. Fuentes Manso, JC. Gallego Page, JC. Garcia Lopez, MJ. Barambio Ruiz, S. Iancovici, E. Ianovici, D. Zamfir, M. Dorobantu, N. Kizhvatova, M. Kolodina, K. Skaletsky, N. Soroka, S. Mayngart, E. Kosmacheva, K. Barbukhatti, V. Porhanov, C. Jurcut, R. Enache, BA. Popescu, C. Ginghina, P. Spirito, R. Jurcut, A. Tomaszewski, E. Czekajska-Chehab, M. Tomaszewski, D. Stettner, A. Wysokinski, P. Fazendas, J. Carvalho, F. Ferreira, L. Sousa, A. Fiarresga, JD. Martins, H. Pereira, A. Jurko, J. Krsiakova, AJR Jurko, K. Matasova, M. Zibolen, S. Babu-Narayan, R. Senior, MA. Gatzoulis, W. Li, G. Maldonado, H. Cuellar, G. Marti, A. Roque, G. Teixido, MT. Gonzalez-Alujas, D. Garcia-Dorado, A. Evangelista, and JF. Rodriguez-Palomares

Subjects
Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine
Published
2016

6. P1088Match and mismatch between opening area and resistance in mild and moderate rheumatic mitral stenosisP1089When should cardiovascular magnetic resonance imaging be considered in patients with chronic aortic or mitral regurgitation?P1090Echocardiographic characteristics of aortic valve fenestration with aortic regurgitation for aortic valve repairP1091Aortic regurgitation assessment by 3D transesophageal echocardiography vena contracta area: usefulness and comparison with 2D methods.P1092Characterising cardiomyopathy in mitral regurgitation due to barlow disease: role of CMRP1093Compensatory peripheral increase in artero-venous o2 difference to severe functional mitral regurgitation in heart failureP1094Prognostic impact of concomitant atrioventricular valve regurgitation in patients undergoing transcatheter aortic valve implantationP1095Morphological characterization of vegetations by real-time three-dimensional transesophageal echocardiography in infective endocarditis: prognostic impactP1096Relation between causative pathogen and echocardiographic findings in patients with infective endocarditis: is there an association and is it clinically relevant?P1097Aortic and mitral valve infective endocarditis: different clinical and echocardiographic features and peculiar complication ratesP1098Vegetation size relevance and impact on prognosis in patients with infective endocarditisP1099Causes of death on the valvular heart disease surveillance list- a 5 year auditP1100Left ventricular non-compaction and idiopathic dilated cardiomyopathy: the significant diagnostic value of longitudinal strainP1101The role of echocardiography in the management of diuretics withdrawal in patients with chronic heart failure and severely reduced ejection fraction: a prospective cohort studyP1102Outcomes in paediatric new onset left ventricle dysfunction and dilatation: differences between post-myocarditis and DCMP1103De novo mitral regurgitation as a cause of heart failure exacerbation in hypertrophic cardiomyopathyP1104Correlation of conventional and new echocardiograhic parameters with sudden cardiac death risk score in patients with hypertrophic cardiomyopathyP1105Inverse correlation between myocardial fibrosis and left ventricular function in rheumatic mitral stenosis: a preliminary study with cardiac magnetic resonanceP1106Left ventricular diastolic dysfunction and cardiac sympathetic derangement in patients with Anderson-Fabry disease: a 2D speckle tracking echocardiography and cardiac 123I-MIBG studyP1107Left ventricular hypertrophy and mild cognitive impairment as markers for target organ damage in hypertensive patients with multiple risk factorsP1108Subclinical left ventricular dysfunction in asymptomatic type 1 diabetic childrenP1109Minimal differences shown by echocardiography and NT-proBNP level distinguishing cardiotoxic effect related to breast cancer therapy in patients with or without HER2 expression.P1110Speed of recovery of left ventricular function is not related to the prognosis of takotsubo cardiomyopathy - a portuguese multicenter studyP1111Myocardial dysfunction in Takotsubo cardiomyopathy - more than meets the eye?P1112Obstructive sleep apnea and echocardiographic parameters

Author

N. Wiligorska, G. Neves Pestana, C. Ruivo, MA. Nowakowska, R. Ben Said, T. Yaneva-Sirakova, L. Spinelli, E. Sahara, A. Koyuncu, R. Kuperstein, A. Argiolas, G. Romano, C. Bosseau, HP. Morgan, R. Ilhao Moreira, D. Trifunovic, C. Olmos, M. Drakopoulou, G. Generati, B. Liu, A. Gonzalez Gomez, T. Okubo, CL. Polte, I. El-Dosouky, SA. Gao, KM. Lagerstrand, ÅA Johnsson, O. Bech-Hanssen, K. Mahara, H. Yamamoto, H. Shitan, K. Abe, M. Terada, M. Saito, Y. Nagatomo, S. Takanashi, D. Del Val, JM. Monteagudo, C. Fernandez-Golfin, R. Hinojar, A. Garcia, A. Marco, E. Casas, JJ. Jimenez-Nacher, JL. Zamorano, S. Baig, M. Hayer, N. Edwards, R. Steeds, F. Bandera, E. Alfonzetti, M. Guazzi, K. Toutouzas, K. Stathogiannis, A. Michelongona, G. Latsios, A. Synetos, G. Lazaros, S. Brili, E. Tsiamis, D. Tousoulis, F. Islas, C. Ferrera, C. Sanchez-Enrique, A. Freitas-Ferraz, P. Mahia, P. Marcos-Alberca, G. Tirado, L. Perez De Isla, I. Vilacosta, J. Marinkovic, B. Obrenovic- Kircanski, B. Ivanovic, D. Kalimanovska-Ostric, G. Stevanovic, M. Petrovic, M. Boricic-Kostic, O. Petrovic, V. Tutos, I. Petrovic, J. Petrovic, G. Draganic, J. Stepanovic, B. Vujisic-Tesic, M. Coutinho Cruz, L. Moura Branco, A. Galrinho, L. Coutinho Miranda, L. Almeida Morais, P. Modas Daniel, I. Rodrigues, J. Fragata, R. Cruz Ferreira, AT. Timoteo, S. Viveiros Monteiro, S. Aguiar Rosa, M. Nana, C. Constantin, F. Tarando, E. Galli, C. Rousseau, A. Hubert, C. Leclercq, E. Donal, G. Vitale, V. Agnese, C. Mina', S. Magro, C. Falletta, G. Di Gesaro, D. Bellavia, F. Clemenza, ER. Elena Reffo, OM. Ornella Milanesi, R. Klempfner, S. Ben-Zekry, E. Maor, E. Raanani, E. Ofek, D. Freimark, M. Arad, E. Oflar, S. Ciftci, I. Ungan, FM. Caglar, L. Ocal, A. Kilicgedik, C. Toprak, G. Kahveci, C. Atmadikoesoemah, M. Kasim, T. Pellegrino, A. Pisani, CA. Giudice, E. Riccio, M. Imbriaco, A. Cuocolo, B. Trimarco, R. Tarnovska-Kadreva, L. Traykov, D. Vassilev, L. Vladimirova, M. Shumkova, I. Gruev, I. Zairi, K. Mzoughi, F. Ben Moussa, S. Kammoun, S. Fennira, S. Kraiem, L. Chrzanowski, K. Frynas-Jonczyk, K. Wdowiak-Okrojek, P. Wejner-Mik, P. Lipiec, M. Krakowska, P. Potemski, E. Plonska-Gosciniak, JD. Kasprzak, N. Marques, K. Domingues, C. Lourenco, R. Santos, C. Gomes, L. Abreu, L. Reis, M. Moz, O. Azevedo, M. Tavares-Silva, C. Sousa, R. Pinto, V. Ribeiro, M. Vasconcelos, P. Bernardo-Almeida, F. Macedo, MJ. Maciel, D. Wiligorska, P. Talarowska, A. Segiet, O. Mozenska, and DA. Kosior

Subjects
medicine.medical_specialty, business.industry, Diastole, Hemodynamics, General Medicine, medicine.disease, Confidence interval, Stenosis, medicine.anatomical_structure, Mitral valve stenosis, Internal medicine, Mitral valve, Severity of illness, medicine, Vascular resistance, Cardiology, Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine, business
Abstract

Background Mitral valve resistance (MVR) is a hemodynamic consequence of mitral stenosis but it has no clear threshold and it has a shortage of data to be reliable. Purpose is to investigate match and mismatch between opening area and resistance especially in patients with moderate and mild mitral stenosis. Materials This cross section case control study comprised 88 patients with moderate and mild rheumatic mitral stenosis. Transthorathic echocardiographic study estimated: mitral valve area (MVA) both by planimerty (2D) and pressure half time (PHT), mitral valve score (MVS), mean transmitral pressure gradient (MPG), diastolic filling time(DFT), left ventricular out flow tract diameter (LVOTd) and velocity time integral (LVOT vti) , the MVR was calculated as: MPG/aortic flow ratio [(LVOTd) (LVOTvti)/ DFT] in dynes.sec.cm5, NYHA function class of all patients was estimated. We classified our patients into 2 groups, group 1 (51 patients) with matched MVR and group 2 (37 patients) with unmatched MVR (unexpected high MVR in relation to valve area). Methods Patients with moderate mitral stenosis have MVR less than 105 dynes.sec/cm5, while patient with mild mitral stenosis have MVR less than 76 dynes.sec/cm5 this is in the matched group, but there are patients with unmatched higher MVR. Group 2 compared to group 1; had higher NYHA function class (1.4±0.6 vs. 1.2±0.4, P < 0.05), MVS (8.1±1.8 vs 7±0.9, P < 0.05), MPG (11,3±3.7 vs.7.8±2.5 mmHg, P < 0.01) and higher MVR (122.37±29.87 vs. 67.18±20.12 dynes.sec/cm5 , P < 0.01), MVR showed positive correlation with MVS (r=0.5, P < 0.05), Step wise logistic regression analysis showed that MVS is the only independent predictor of the MVR severity in the mismatched (unexpected high) group , so the higher the MVS the higher the expected MVR whatever the MVA is ; (B±SE=6.997±2.826, t=2.476, 95% CI 1.241±12.752 with an odds ratio=0.412, P < 0.05). Conclusion It would make much more sense to investigate match and mismatch between opening area and resistance in rheumatic mitral stenosis, the only independent predictor of mismatch is the mitral valve score.

Published
2016

7. Poster session 2THE IMAGING EXAMINATIONP536Appropriate use criteria of transthoracic echocardiography and its clinical impact: a continuous challengeP537Implementation of proprietary plug-ins in the DICOM-based computerized echo reporting system fuels the use of 3D echo and deformation imaging in the clinical routine of a multivendor laboratoryP538Exercise stress echocardiography appropriate use criteria: real-life cases classification ease and agreement among cardiologistsANATOMY AND PHYSIOLOGY OF THE HEART AND GREAT VESSELSP539Functional capacity in older people with normal ejection fraction correlates with left ventricular functional reserve and carotid-femoral pulse wave velocity but not with E/e and augmentation indexP540Survey of competency of practitioners for diagnosis of acute cardiopulmonary diseases manifest on chest x-rayASSESSMENT OF DIAMETERS, VOLUMES AND MASSP541Left atrium remodeling in dialysis patients with normal ejection fractionP542The prediction of postinfarction left ventricular remodeling and the role of of leptin and MCP-1 in regard to the presence of metabolic syndromeP543Ascending aorta and common carotid artery: diameters and stiffness in a group of 584 healthy subjectsAssessments of haemodynamicsP544Alternate echo parameters in patients without estimable RVSPAssessment of systolic functionP545Reduced contractile performance in heart failure with preserved ejection fraction: determination using novel preload-adjusted maximal left ventricular ejection forceP546Left ventricular dimensions and prognosis in acute coronary syndromesP547Time course of myocardial alterations in a murine model of high fat diet: A strain rate imaging studyP548Subclinical left ventricular systolic dysfunction in patients with premature ventricular contractionsP549Global myocardial strain by CMR-based feature tracking (FT) and tagging to predict development of severe left ventricular systolic dysfunction after acute st-elevation myocardial infarctionP550Echocardiographic analysis of left and right ventricular function in patients after mitral valve reconstructionP551The role of regional longitudinal strain assessment in predicting response to cardiac resynchronization therapy in patients with left ventricular systolic dysfunction and left bundle branch blockP552Speckle tracking automatic border detection improves echocardiographic evaluation of right ventricular systolic function in repaired tetralogy of fallot patients: comparison with MRI findingsP553Echocardiography: a reproducible and relevant tool in pah? intermediate results of the multicentric efort echogardiographic substudy (evaluation of prognostic factors and therapeutic targets in pah)Assessment of diastolic functionP554Relationship between left ventricular filling pressures and myocardial fibrosis in patients with uncomplicated arterial hypertensionP555Cardiac rehabilitation improves echocardiographic parameters of diastolic function in patients with ischemic heart diseaseP556Diastolic parameters in the calcified mitral annulusP557Biomarkers and echocardiography - combined weapon to diagnose and prognose heart failure with and without preserved ejection fractionP558Diastolic function changes of the maternal heart in twin and singleton pregnancyIschemic heart diseaseP559Syntax score as predictor for the correlation between epicardial adipose tissue and the severity of coronary lesions in patients with significant coronary diseaseP560Impact of strain analysis in ergonovine stress echocardiography for diagnosis vasospastic anginaP561Cardiac magnetic resonance tissue tracking: a novel method to predict infarct transmurality in acute myocardial infarctionP562Infarct size is correlated to global longitudinal strain but not left ventricular ejection fraction in the early stage of acute myocardial infarctionP563Magnetic resonance myocardial deformation assessment with tissue tracking and risk stratification in acute myocardial infarction patientsP564Increase in regional end-diastolic wall thickness by transthoracic echocardiography as a biomarker of successful reperfusion in anterior ST elevation acute myocardial infarctionP565Mitral regurgitation is associated with worse long-term prognosis in ST-segment elevation myocardial infarction treated with primary percutaneous coronary interventionP566Statistical significance of 3D motion and deformation indexes for the analysis of LAD infarctionHeart valve DiseasesP567Paradoxical low gradient aortic stenosis: echocardiographic progression from moderate to severe diseaseP568The beneficial effects of TAVI in mitral insufficiencyP569Impact of thoracic aortic calcification on the left ventricular hypertrophy and its regression after aortic valve replacement in patients with severe aortic stenosisP570Additional value of exercise-stress echocardiography in asymptomatic patients with aortic valve stenosisP571Valvulo-arterial impedance in severe aortic stenosis: a dual imaging modalities studyP572Left ventricular mechanics: novel tools to evaluate left ventricular performance in patients with aortic stenosisP573Comparison of long-term outcome after percutaneous mitral valvuloplasty versus mitral valve replacement in moderate to severe mitral stenosis with left ventricular dysfunctionP574Incidence of de novo left ventricular dysfunction in patient treated with aortic valve replacement for severe aortic regurgitationP575Transforming growth factor-beta dependant progression of the mitral valve prolapseP576Quantification of mitral regurgitation with multiple jets: in vitro validation of three-dimensional PISA techniqueP577Impaired pre-systolic contraction and saddle-shape deepening of mitral annulus contributes to atrial functional regurgitation: a three-dimensional echocardiographic studyP578Incidence and determinants of left ventricular (lv) reverse remodeling after MitraClip implantation in patients with moderate-to severe or severe mitral regurgitation and reduced lv ejection fractionP579Severe functional tricuspid regurgitation in rheumatic heart valve disease. New insights from 3D transthoracic echocardiographyP58015 years of evolution of the etiologic profile for prosthetic heart valve replacement through an echocardiography laboratoryP581The role of echocardiography in the differential diagnosis of prolonged fever of unknown originP582Predictive value for paravalvular regurgitation of 3-dimensional anatomic aortic annulus shape assessed by multidetector computed tomography post-transcatheter aortic valve replacementP583The significance and advantages of echo and CT imaging & measurement at transcatherter aortic valve implantation through the left common carotid accessP584Comparison of the self-expandable Medtronic CoreValve versus the balloon-expandable Edwards SAPIEN bioprostheses in high-risk patients undergoing transfemoral aortic valve implantationP585The impact of transcatheter aortic valve implantation on mitral regurgitation severityP586Echocardiographic follow up of children with valvular lesions secondary to rheumatic heart disease: Data from a prospective registryP587Valvular heart disease and different circadian blood pressure profilesCardiomyopathiesP588Comparison of transthoracic echocardiography versus cardiac magnetic for implantable cardioverter defibrillator therapy in primary prevention strategy dilated cardiomyopathy patientsP589Incidence and prognostic significance of left ventricle reverse remodeling in a cohort of patients with idiopathic dilated cardiomyopathyP590Early evaluation of diastolic function in fabry diseaseP591Echocardiographic predictors of atrial fibrillation development in hypertrophic cardiomyopathyP592Altered Torsion mechanics in patients with hypertrophic cardiomyopathy: LVOT-obstruction is the topdog?P593Prevention of sudden cardiac death in hypertrophic cardiomyopathy: what has changed in the guidelines?P594Coronary microcirculatory function as determinator of longitudinal systolic left ventricular function in hypertrophic cardiomyopathyP595Detection of subclinical myocardial dysfunction by tissue Doppler ehocardiography in patients with muscular dystrophiesP596Speckle tracking myocardial deformation analysis and three dimensional echocardiography for early detection of chemotherapy induced cardiac dysfunction in bone marrow transplantation patientsP597Left ventricular non compaction or hypertrabeculation: distinguishing between physiology and pathology in top-level athletesP598Role of multi modality imaging in familiar screening of Danon diseaseP599Early impairment of global longitudinal left ventricular systolic function independently predicts incident atrial fibrillation in type 2 diabetes mellitusP600Fetal cardiovascular programming in maternal diabetes mellitus and obesity: insights from deformation imagingP601Longitudinal strain stress echo evaluation of aged marginal donor hearts: feasibility in the Adonhers project.P602Echocardiographic evaluation of left ventricular size and function following heart transplantation - Gender mattersSystemic diseases and other conditionsP603The impact of septal kinetics on adverse ventricular-ventricular interactions in pulmonary stenosis and pulmonary arterial hypertensionP604Improvement in right ventricular mechanics after inhalation of iloprost in pulmonary hypertensionP605Does the treatment of patients with metabolic syndrome correct the right ventricular diastolic dysfunction?P606Predictors of altered cardiac function in breast cancer survivors who were treated with anthracycline-based therapyP607Prevalence and factors related to left ventricular systolic dysfunction in asymptomatic patients with rheumatoid arthritis: a prospective tissue-doppler echocardiography studyP608Diastolic and systolic left ventricle dysfunction presenting different prognostic implications in cardiac amyloidosisP609Diagnostic accuracy of Bedside Lung Ultrasonography in Emergency (BLUE) protocol for the diagnosis of pulmonary embolismP610Right ventricular systolic dysfunction and its incidence in breast cancer patients submitted to anthracycline therapyP611Right ventricular dysfunction is an independent predictor of survival among cirrhotic patients undergoing liver transplantCongenital heart diseaseP612Hypoplasia or absence of posterior leaflet: a rare congenital anomaly of the mitral valveP613ECHO screening for Barlow disease in proband's relativesDiseases of the aortaP614Aortic size distribution and prognosis in an unselected population of patients referred for standard transthoracic echocardiographyP615Abdominal aorta aneurysm ultrasonographic screening in a large cohort of asympromatic volounteers in an Italian urban settingP616Thoracic aortic aneurysm and left ventricular systolic functionStress echocardiographyP617Wall motion score index, systolic mitral annulus velocity and left ventricular mass predicted global longitudinal systolic strain in 238 patients examined by stress echocardiographyP618Prognostic parameters of exercise-induced severe mitral valve regurgitation and exercise-induced systolic pulmonary hypertensionP619Risk stratification after myocardial infarction: prognostic value of dobutamine stress echocardiographyP620relationship between LV and RV myocardial contractile reserve and metabolic parameters during incremental exercise and recovery in healthy children using 2-D strain analysisP621Increased peripheral extraction as a mechanism compensatory to reduced cardiac output in high risk heart failure patients with group 2 pulmonary hypertension and exercise oscillatory ventilationP622Can exercise induced changes in cardiac synchrony predict response to CRT?Transesophageal echocardiographyP623Fully-automated software for mitral valve assessment in chronic mitral regurgitation by three-dimensional transesophageal echocardiographyP624Real-time 3D transesophageal echocardiography provides more accurate orifice measurement in percutaneous transcatheter left atrial appendage closureP625Percutaneous closure of left atrial appendage: experience of 36 casesReal-time three-dimensional TEEP626Real-time three-dimensional transesophageal echocardiography during pulmonary vein cryoballoon ablation for atrial fibrilationP627Three dimensional ultrasound anatomy of intact mitral valve and in the case of type 2 disfunctionTissue Doppler and speckle trackingP629Left ventricle wall motion tracking from echocardiographic images by a non-rigid image registrationP630The first experience with the new prototype of a robotic system for remote echocardiographyP631Non-invasive PCWP influence on a loop diuretics regimen monitoring model in ADHF patients.P632Normal range of left ventricular strain, dimensions and ejection fraction using three-dimensional speckle-tracking echocardiography in neonatesP633Circumferential ascending aortic strain: new parameter in the assessment of arterial stiffness in systemic hypertensionP634Aortic vascular properties in pediatric osteogenesis imperfecta: a two-dimensional echocardiography derived aortic strain studyP635Assessment of cardiac functions in children with sickle cell anemia: doppler tissue imaging studyP636Assessment of left ventricular function in type 1 diabetes mellitus patients by two-dimensional speckle tracking echocardiography: relation to duration and control of diabetesP637A study of left ventricular torsion in l-loop ventricles using speckle-tracking echocardiographyP638Despite No-Reflow, global and regional longitudinal strains assessed by two-dimensional speckle tracking echocardiography are predictive indexes of left ventricular remodeling in patients with STEMIP639The function of reservoir of the left atrium in patients with medicaly treated arterial hypertensionP640The usefulness of speckle tracking analysis for predicting the recovery of regional systolic function after myocardial infarctionP641Two dimensional speckle tracking echocardiography in assessment of left ventricular systolic function in patients with rheumatic severe mitral regurgitation and normal ejection fractionP642The prediction of left-main and tripple vessel coronary artery disease by tissue doppler based longitudinal strain and strain rate imagingP643Role of speckle tracking in predicting arrhythmic risk and occurrence of appropriate implantable defibrillator Intervention in patients with ischemic and non-ischemic cardiomyopathyComputed Tomography & Nuclear CardiologyP644Cardiac adrenergic activity in patients with nonischemic dilated cardiomyopathy. Correlation with echocardiographyP645Different vascular territories and myocardial ischemia, there is a gradient of association?

Author

M Corneli, J C Gallego Page, C Soro, A Sharma, H Y A Girgis, K Wdowiak-Okrojek, D Djikic, F Granata, A Toscano, H A Habeeb, HA Hadeed, L Li, S Ben Kahla, G Di Salvo, I Sharka, D Szczesniak-Stanczyk, S Ranjbar, S Kadrabulatova, L Asmarats Serra, L Lanzoni, H-L Cheng, I Aquila, JJ Van Zalen, G Generati, G E Pieles, N Laredj, H Lesevic, K Wierzbowska-Drabik, E Malev, G Corrado, A Cherubini, S Kovalova, V M Parato, N Naksuk, G Portugal, A Ledakowicz-Polak, L Almeida Morais, G Cioffi, A Barac, D Radulescu, O Tufekcioglu, MMP Driessen, A Ingvarsson, M Cameli, A Kulkarni, S Bonapace, M Dantas Tavares De Melo, F D'ascenzi, G Makavos, M Gospodinova, D Trifunovic, L Reis, L Halmai, G Avegliano, L Caballero, F Macaya Ten, G Pontone, O Mozenska, A Saxena, S Guerreiro, P Kogoj, E Remsey- Semmelweiss, V Ciobotaru, J Petrovic, JA De La Chica, P Mahia, S Cimino, Z Tang, F Zuercher, M Mariani, KH Kim, E Galli, W Lam, C Goublaire, I J Cho, MF Costantino, E Fabris, N Duchateau, F Cordeiro, MC Scali, F Valente, G Joseph, SJ Ha, J D Morales Portano, S Prado Diaz, P Trzcinski, JN Codolosa, C Contaldi, M Orabona, M Chinali, A Lisowska, S Stoebe, A Shetye, SELEN Yurdakul, J Ternacle, JM Ribeiro, T T Le, VY Mo, O Vriz, BW Michalski, N Hanboly, G Mehdipoor, T Erdei, A Garcia Campos, L Badano, S Martins Fernandes, R Teixeira, I Roussin, M Lynch, D Muraru, G Romeo, D Ermacora, C Marotta, P Aruta, U Cucchini, S Iliceto, M Martin-Fernandez, JM De La Hera Galarza, C Corros-Vicente, S Colunga Blanco, E Velasco-Alonso, V Leon-Aguero, ML Rodriguez-Suarez, C Moris De La Tassa, J Edwards, D Braim, C Price, AG Fraser, F Salmani, A Arjmand Shabestari, E Szymczyk, K Kupczynska, L Peczek, B Nawrot, P Lipiec, JD Kasprzak, C Driussi, F Ferrara, G Brosolo, F Antonini-Canterin, J Magne, V Aboyans, E Bossone, BM Bellucci, JM Fisher, AA Balekian, S Idapalapati, F Huang, JI Wong, RS Tan, M Madeira, I Almeida, A Siserman, P Dinis, L Dias, AP Ramos, L Goncalves, FW Wan, DS Sawaki, JLDR Dubois-Rande, SA Adnot, GC Czibik, GD Derumeaux, G Ercan, ILKER Tekkesin, ST Sahin, B Cengiz, G Celik, S Demircan, SAIDE Aytekin, NA Razvi, SA Nazir, N Price, JN Khan, P Kanagala, A Singh, I Squire, GP Mccann, M Langel, D Pfeiffer, A Hagendorff, K Ptaszynska-Kopczynska, M Marcinkiewicz-Siemion, M Knapp, M Witkowski, WJ Musial, K Kaminski, B Natali, C D' Anna, B Leonardi, A Secinaro, G Pongiglione, G Rinelli, S Renard, N Michel, J Mancini, J Haentjens, O Sitbon, G Habib, M Imbriaco, G Alcidi, C Santoro, A Buonauro, F Lo Iudice, M Lembo, A Cuocolo, B Trimarco, M Galderisi, J Mora Robles, MA Roldan Jimenez, MA Mancisidor, MA De Mora, T Alnabelsi, I Goykhman, N Koshkelashvili, A Romero-Corral, GS Pressman, D Miskowiec, N Montoro Lopez, E Refoyo Salicio, SC Valbuena Lopez, O Gonzalez, C Alvarez, M Moreno Yanguela, JL Bartha Rasero, M De La Calle, G Guzman Martinez, JA Suarez-Cuenca, JA Merino, E B Gomez Alvarez, LG Delgado, YM Woo, WD Bang, GH Sohn, SS Cheong, SY Yoo, JF Rodriguez Palomares, L Gutierrez, G Maldonado, V Pineda, L Galian, G Teixido, MT Gonzalez Allujas, A Evangelista, D Garcia Dorado, T Zaremba, S Ekeloef, E Heiberg, H Engblom, SE Jensen, P Sogaard, G Garcia, FL Dini, F Galli, F Lattanzi, E Picano, M Marzilli, S Leao, M Moz, P Magalhaes, J Trigo, PS Mateus, A Ferreira, JI Moreira, M De Craene, D Legallois, F Labombarda, A Pellissier, M Sermesant, E Saloux, M Merlo, M Moretti, G Barbati, D Stolfo, M Gigli, B Pinamonti, G Sinagra, E Dores, A Matera, P Innelli, A Lopizzo, R Violini, R Fiorilli, G Cappabianca, G Tarsia, J Seo, HJ Chang, R Heo, IC Kim, CY Shim, GR Hong, N Chung, MM Melissopoulou, V Nguyen, E Brochet, C Cimadevilla, I Codogno, A Vahanian, D Messika-Zeitoun, F Pontana, V Vassiliou, S Prasad, C Leclercq, E Samset, E Donal, DS Lim, G Bianchi, F Rossi, J Gianetti, F Marchi, E Cerone, A Nardelli, M Terrazzi, M Solinas, S Maffei, A Pshepiy, L Vasina, E Timofeev, S Reeva, E Zemtsovsky, N Brugger, S Jahren, SF De Marchi, C Seiler, CN Jin, H Tang, K Fan, K Kam, BP Yan, CM Yu, PW Lee, M Reali, E Silvetti, T Salatino, M Mancone, M Pennacchi, A Giordano, G Sardella, L Agati, G Tirado, MT Nogales-Romo, P Marcos-Alberca, A De Agustin, C Almeria, JL Rodrigo, MA Garcia Fernandez, C Macaya, L Perez De Isla, M Mancisidor, C Lara Garcia, R Vivancos, M De Mora, M Petrovic, B Vujisic-Tesic, M Boricic-Kostic, I Petrovic, G Draganic, O Petrovic, M Tomic-Dragovic, T Furlan, J Ambrozic, PN Mohorko Pleskovic, M Bunc, R Ribeiras, J Abecasis, MJ Andrade, M Mendes, S Ramakrishnan, SK Gupta, R Juneja, SS Kothari, M Zaleska, A Segiet, S Chwesiuk, A Kroc, DA Kosior, D Andreini, A Solbiati, M Guglielmo, S Mushtaq, A Baggiano, V Beltrama, C Rota, AI Guaricci, M Pepi, J Pons Llinares, P Pericas Ramis, O Caldes Llull, A Grau Sepulveda, G Frontera, A Vaquer Segui, M Noris, A Bethencourt Gonzalez, V Climent Paya, M Martinez Moreno, D Saura, MJ Oliva, J Sanchez Quinones, A Garcia Honrubia, M Valdes, G De La Morena, M Terricabras, JP Costabel, R Ronderos, C Venturini, E Galve, A Nemes, S Neubauer, S Rahman Haley, N Banner, F Caetano, A Botelho, J Silva, J Nascimento, M Tesic, I Jovanovic, M Dragovic, J Stepanovic, M Banovic, V Guergelcheva, T Chamova, S Sarafov, I Tournev, S Denchev, I Ikonomidis, P Psarogiannakopoulos, P Tsirigotis, I Paraskevaidis, J Lekakis, A Pelliccia, BM Natali, M Focardi, M Bonifazi, S Mondillo, C Lima, L Assed, R Kalil Filho, C Mady, E A Bochi, V M C Salemi, G Targher, F Valbusa, A Rossi, P Lipari, L Zenari, G Molon, G Canali, E Barbieri, M Craft, M Nanda, JM Lorenzo, S Kutty, T Bombardini, S Sparla, C Di Tommaso, M Losito, E Incampo, M Maccherini, A Werther Evaldsson, G Radegran, M Stagmo, J Waktare, A Roijer, CJ Meurling, W Hui, FJ Meijboom, B Bijnens, A Dragulescu, L Mertens, MK Friedberg, B Sensoy, M Suleymanoglu, Y Akin, E Sahan, H Sasmaz, L Pasca, E Buzdugan, B Chis, L Stoicescu, FC Lynce, KL Smith, M Mete, C Isaacs, O Viapiana, C Di Nora, F Ognibeni, E Fracassi, A Giollo, C Mazzone, G Faganello, A Di Lenarda, M Rossini, A Galrinho, L Branco, A T Timoteo, I Rodrigues, P Daniel, S Rosa, L Ferreira, R Ferreira, L Polak, G Krauza, K Stokfisz, M Zielinska, L M Branco, M Mota Carmo, A Teresa Timoteo, S Aguiar Rosa, J Abreu, P Pinto Teixeira, A Viveiros Monteiro, R Cruz Ferreira, T Peeraphatdit, R Chaiteerakij, KW Klarich, S Masia, J Necas, S Nistri, F Negri, G Russo, C Pandullo, A Durante, E Rovelli, V Genchi, L Trabattoni, SC Zerboni, L Cattaneo, E Butti, G Ferrari, E Luneva, L Mitrofanova, V Uspensky, S Rosner, M Karl, I Ott, C Sonne, HM Ali Lahmar, L Hammou, J Forsey, L Gowing, F Miller, P Ramanujam, AG Stuart, CA Williams, F Bandera, M Pellegrino, F Carbone, V Labate, E Alfonzetti, M Guazzi, NR Patel, P Raju, L Beale, G Brickley, GW Lloyd, C Fernandez-Golfin, A Gonzalez, LM Rincon, R Hinojar, A Garcia, A Megias, JJ Jimenez-Nacher, JL Moya, JL Zamorano, A Chiampan, L Albrigi, M Noris Mora, A Rodriguez Fernandez, C Exposito Pineda, C Grande, R Gonzalez Colino, X Fernandez Vazquez, E Fortuny Frau, M Karvandi, R Blaszczyk, R Zarczuk, W Brzozowski, M Janowski, A Wysokinski, B Stanczyk, S Myftiu, D Teferici, A Quka, E Dado, J Djamandi, L Kresto, A Duka, A Kristo, I Balla, Z Issa, N Moiduddin, G Siblini, Z Bulbul, L Abid, D Abid, S Kammoun, E Rush, J Goodwin, R Kreikemeier, M Cantinotti, M A Zolaly, SQ Khoshhal, K El-Harbi, A Tarawah, Z Al-Hawsawi, I Al-Mozainy, S W G Bakhoum, M N Nabil, I N Elebrashy, S Albanese, A Carotti, R Iacobelli, C Esposito, G Moscogiuri, L Pasquini, M Malvezzi Caracciolo, RM Bianchi, P Caso, F Arenga, L Riegler, R Scarafile, A D'andrea, MG Russo, P Calabro', DS Simic, VP Peric, NM Mujovic, MM Marinkovic, NJ Jankovic, A Shim, P Wejner-Mik, N Jain, R Kharwar, RK Saran, VS Narain, SK Dwivedi, R Sethi, S Chandra, A Pradhan, S Safal, MF Marchetti, C Cacace, M Congia, V Nissardi, M Ruscazio, L Meloni, R Montisci, G Gallego Sanchez, S Calero, JJ Portero, A Tercero, JC Garcia, M Barambio, R Martinez Lazaro, AH Meretta, GO Perea, F Belcastro, E Aguirre, I De Luca, R Henquin, and O Masoli

Subjects
medicine.medical_specialty, Ejection fraction, Longitudinal strain, business.industry, General Medicine, Deformation (meteorology), medicine.disease, Infarct size, Surgery, Internal medicine, Cardiology, Medicine, Radiology, Nuclear Medicine and imaging, Myocardial infarction, Stage (cooking), Cardiology and Cardiovascular Medicine, business, Radial stress, Relevant information
Abstract

Purpose: Deformation analysis from 3D echocardiography results in a considerable amount of parameters, for which the conventional statistical approach is cumbersome. We investigate local motion and deformation patterns to determine the parameters of relevance for the study of LV myocardial deformation in the presence of LAD infarct. Methods: The study included 46 patients acquired at max. 5 days after LAD infarct (37 sequences) and at 1-year follow-up (33 sequences), and 46 controls. Patients were selected if they had a LVEF

Published
2015

8. Poster session 1GENERAL PRINCIPLESP194Ultrasound indexes of adipose tissue and lipid goals attainment in high and very high cardiovascular risk patientsTHE IMAGING EXAMINATIONP195Right ventricular global longitudinal strain provides higher prognostic value than right free wall longitudinal strain in patients with left heart diseaseP196Normal values of echocardiographlc left and right cardiac chambers dimensions as multifactorially determined by sex, level of physical activity, age, BMI, systolic blood pressure and heart rateAnatomy and physiology of the heart and great vesselsP197Echocardiographic phenotypes according to levels of oxygen consumption at peak exercise: findings from the EURO(pean) EX(ercise) population-based studyAnatomy and physiology of the heart and great vesselsP198Systemic vascular resistance and central arterial stiffness in relation to left ventricular geometry and diastolic function in essential hypertensionAssessment of diameters, volumes and massP199Left atrial diameter predicts a new diagnosis of paroxysmal atrial fibrillation in a population presenting with palpitationsP200Interventricular septum thickness and acute coronary syndromes: small differences, big prognostic influence?P201Detection of abdominal aortic aneurysm in a population referred for an ultrasonographyAssessments of haemodynamicsP202The ultrasound vector velocity method transverse oscillation validated in a flowrig with constant and pulsatile flow and in-vivo of blood flow in the ascending aortaASSESSMENT OF SYSTOLIC FUNCTIONP203Different types of left ventrical remodeling in children with arterial hypertensionP204Assessment of myocardial performance index in hypertensive patients with or without hyperuricemiaP205Strain echocardiography detects mild impairment of systolic function in patients with frequent premature ventricular contractionsP206Speckle tracking strain correlates better with functional capacity and hemodynamic burden than ejection fraction in patients with severe heart failureP207Prognostic value of 2D and 3D echocardiographic volumes, ejection fraction and strain as markers of abnormal left ventricular performanceP208Long-term prognostic value of left ventricular ejection fraction assessed by echocardiography and magnetic resonance imaging after acute STEMIP209Assessment of left ventricular function after percutaneous coronary intervention of chronic total occluded coronary artery by speckle tracking and cardiac magnetic resonanceP210Physiologic variations of tricuspid annular plane systolic excursion in healthy subjects: clinical and echocardiographic correlatesP211Predictors of incipient ventricular dysfunction with tyrosine kinase inhibitors in metastatic renal cell carcinomaAssessment of diastolic functionP212Disagreement between the American Society of Echocardiography (ASE) and gastroenterology-based guidelines for the diagnosis of diastolic dysfunction among patients with advanced liver diseaseP213Nomograms for mitral inflow doppler and tissue doppler velocities in caucasian childrenP215Diastolic function is impaired in women with angina pectoris and no obstructive coronary artery disease independently of coronary microvascular functionP216Clinical value of myocardial performance index in patients with isolated diastolic dysfunctionIschemic heart diseaseP217Cardiac imaging strategy is clinically more effective and at lower cost than traditional ETT strategy for the diagnosis of stable coronary artery diseaseP218Does the ESC clinical pretest probability score stratify our patients correctly? Validation with stress echocardiographyP219Incremental value of exercise echocardiography over exercise electrocardiography in a chest pain unit: a decision curve analysisP220A bedside echocardiographic score for risk stratification of ST-elevation myocardial infarction patients undergoing primary percutaneous coronary interventionP221Interventricular and intraventricular dyssynchrony in patients with Q-wave acute myocardial infarctionP222Comparison of tagging and tissue tracking for myocardial strain assessment at 1.5T and 3.0T following ST-segment elevation myocardial infarctionP223Left atrial strain rate evaluated by two-dimensional speckle tracking is predictor of left ventricular arrhythmias in STEMI patients treated by primary PCIP224Impact of percutaneous coronary intervention of chronic total oclussion on left ventricular function using speckle tracking and cardiac magnetic resonanceHeart valve DiseasesP225Clinical and echocardiographic characteristics of patients with low flow severe aortic stenosis and preserved ejection fractionP226Ventricular-arterial interplay in patients with severe aortic stenosis: additional role of wave intensity analysisP227Degenerative aortic stenosis: don't forget the vascular componentP228Reclassifying low gradient aortic stenosis with 3D transesophageal echocardiography and global longitudinal strainP229Importance of mitral regurgitation on pre- and postoperative clinical status and echocardiographic findings in patients with severe aortic stenosis admitted for aortic valve replacementsP230Aorto-septal angle and degenerative aortic stenosis: a case-control study stenosisP231Difference of sST2 level in mitral stenosis compare with control subjectsP232Velocity-time integral of aortic regurgitation: a novel echocardiographic marker in the evaluation of aortic regurgitation severityP233Color doppler 3D echocardiography-derived regurgitant volume in primary mitral regurgitation: a comparison of different techniques with magnetic resonanceP234Outcome of surgery for degenerative mitral regurgitationP235Mitral valve repair or replacement for functional regurgitation and left ventricular dysfunction: clinical and echocardiographic outcomeP236Prevalence, characteristics and prognosis of moderate to severe tricuspid regurgitation in patients with precapillary pulmonary hypertensionP237Management of late bioprosthetic mitral valve thrombosisP238Relationship between pulmonary venous flow and prosthetic mitral valve thrombosisP239Transcatheter aortic valve implantation does not reduce acutely valvuloarterial impedance in an elderly population with degenerative calcific aortic valve stenosisP240Influence of type of prosthesis on mitral regurgitation change after transcatheter aortic valve replacement for aortic stenosisP241The prevalence of valve disease in patients undergoing atrial fibrillation ablationCardiomyopathiesP242The prognostic value of lung ultrasound at discharge in heart failureP243Prognostic value of global longitudinal strain in non-ischaemic dilated cardiomyopathyP244Additional effect of high intensity exercise training to cardiac resynchronization in heart failure: the reduction on left venticular massP245Dobutamine-induced changes of longitundinal strain predicts longterm mortality in severe heart failureP246Myocardial fibrosis is not related to two-dimensional longitudinal strain in dilated cardiomyopathyP247Echocardiographic parameters are predictors of positive genetic study in a Portuguese population with hypertrophic cardiomyopathy: a multicentre studyP248Myocardial deformation techniques for the evaluation of the right ventricle in fabry diseaseP249Borderline hypertrophic cardiomyopathy or athlete's heart: what is the role for genetic testing in athletes?P250Isolated papillary muscle hypertrophy. Clinical, electrocardiographic and morphologic characteristicsP251Prognostic value of the assessment of left atrial deformation in hypertrophic cardiomyopathyP252Assessment of subtle echocardiographic changes may improve risk stratification of arrhythmias in early stages of arrhythmogenic right ventricular cardiomyopathy (ARVC)P253Long-term correlation of electrocardiography with structural echocardiography changes in patients with arrhythmogenic right ventricular cardiomyopathyP254Right ventricular strain and dyssynchrony assessment in arrhythmogenic right ventricular cardiomyopathy: a cardiac magnetic resonance feature-tracking studyP255Association of non compaction and hypertrophic cardiomyopathies, Noonan and long QT syndromesP256Predictors of mortality in patients with acute myocarditisP257Clinical characteristics and natural history of acute myocarditisP258One-beat 3dimensional echocardiography for the assessment of right ventricular function in heart transplant recipientsP259Hemodynamically irrelevant, non-surgery related pericardial effusion is a predictor of mortality in heart transplanted patientsSystemic diseases and other conditionsP260Left ventricular function as a cardiac marker of target organ damage in non-diabetic, never treated hypertensive patients: Camparison with microalbuminuriaP261Subclinical myocardial dysfunction in hypertensive patients with hyperuricemiaP262Can deformation indices (strain/strain rate) establish differential diagnosis in infiltrative cardiomyopathies?P263Prevalence and factors associated with inappropriately high left ventricular mass in patients with rheumatoid arthritisP264Echocardiographic evaluation of patients with end-stage liver disease, the importance of follow up after liver transplantationP265Cardiovasclular involvement in asymptomatic juvenile localized scleroderma patientsP267Can the left ventricular mechanics using speckle tracking echocardiography in pregnancy predict the new onset heart failure?P268What causes impaired exercise tolerance in HFpEF? Relative contribution from LV filling pressure and other factorsCongenital heart diseaseP269Pregnancy in patients with Ebsteins anomaly - echocardiographic and clinical studyP270Double aortic arch anomalies in clinical practiceP271Echocardiography as the essential imaging modality in congenital heart disease - first one to begin with and the one who staysMasses, tumors and sources of embolismP272Can the reduction of wall shear stress in diskinetic myocardial wall segments be used to predict trombogenicity?Diseases of the aortaP273The role of modified transoesophageal echocardiography for optimal access decision making for transcatheter aortic valve replacement proceduresStress echocardiographyP274Is aortic valve resistance different in patients with severe aortic stenosis and left ventricular fraction below 40% with low or high gradient?P275Does wall motion score index in dobutamine stress echocardiography predict syntax score in catheterization lab?P276Sex-related differences in peak stress left ventricular global longitudinal strain during dobutamine stress echocardiography in patients with significant coronary artery diseaseP277Exercise stress echocardiography complications: a 4-year single center experienceP278Reduced baseline left ventricular longitudinal systolic function is a marker of inducible myocardial ischemia in patients undergoing exercise echocardiographyP279Estimation of mean pulmonary arterial pressure based on right ventricle systolic pressure observed from exercise echocardiography among non-pulmonary hypertension with systemic sclerosisTransesophageal echocardiographyP280Transoesophageal echocardiography in patients with neuroendocrine tumour and carcinoid symptoms is safe without intravenous octreotideP281The feasibility and the clinical benefit of the cognitive-behavioral intervention for preparing patients for transesophageal echocardiographic studyP282Dynamic changes of mitral annulus shape in different types of mitral valve prolapse. A three-dimensional transoesophageal studyReal-time three-dimensional TEEP283Severe aortic stenosis: evaluation of effective and anatomy valve by 2D transthoracic echocardiography and 3D transesophageal echocardiographyP2843D-transeosphageal echocardiography usefulness for assessment of cardiac output in intensive care unit: an ultrasound versus thermodilution comparative study for patients under mechanical ventilationP285The predictive value of three-dimensional vena-contracta in determining the number of MitraClip devices needed during the procedure in functional mitral regurgitationTissue Doppler and speckle trackingP286Should the septum be included in the assessment of right ventricular longitudinal strain?P287Can machine learning help to identify heart failure with preserved ejection fraction?P288Concordance of atrial function measurement by 3D volumetric echocardiography and speckle tracking deformation imagingP289Heterogonous regional diastolic function revealed by 2D speckle tracking echocardiography identifies patients with ischemic etiology of left ventricular systolic dysfunctionP290The values from Real time 3-dimensional strain is not independent from preload changesP291Risk stratification in hypertrophic cardiomyopathy. a potential role for speckle-tracking parameters by cardiac magnetic resonanceP292Abnormal longitudinal peak systolic strain in asymptomatic patients with type-I diabetes mellitusP294Strain evaluation of subclinical cardiac dysfunction in patients with myotonic dystrophy type 1P295Heart function assessment in perinatal asphyxia; speckle tracking indices from greyscale recordings perform better than from tissue Doppler recordings, fractional shortening and tissue Doppler indicesP297Longitudinal strain assessed by automatic function imaging - a useful tool in significant coronary artery disease detection in patients with low risk anginaP298Global 2-Dimensional strain as a predictor of mortality in heart transplant patients with cardiac allograft vasculopathyP299Two-dimensional longitudinal strain and strain rate in asymptomatic middle-aged patients with type 2 diabetes mellitus - a pilot study resultsP300Limited accuracy of myocardial deformation imaging in diagnosis of left ventricular segmental dysfunction in patients with acute myocardial infarction: is it only a limitation of the strain software?Computed Tomography & Nuclear CardiologyP301Evaluation of the actual prevalence of myocardial ischemia in patients prior to performing a peripheral vascular surgeryP302Prognostic value of myocardial ischemia detected by myocardial perfusion imaging in asymptomatic patients with diabetes type 2P303Economic cost analysis derived by coronary computed tomography angiography inappropriate indications to rule out coronary heart disease

Author

M Barreiro Perez, IPM Peovska Mitevska, M Corneli, Y Agmon, A Kisko, L Moran, R Onut, E Nestaas, H Guedes, A M Van Berendoncks, R Hinojar, CS Park, E Kowalczyk, S Montserrat, S Sanchez-Martinez, M Sanz, HM Mahmoud, F Laveau, GO Perea, M M Gurzun, P Wejner-Mik, CJH May, K Teramoto, A Cherubini, J F Carvalho, K Wierzbowska-Drabik, A Rohani, R Ferreira, A Hoetink, A Carbonell San Roman, D Stanojevic, M Kaldararova, A M Lesniak-Sobelga, W Kosmala, K Hristova, A Borowiec, S Colunga, F Ognibeni, J L Pena, A Stevanovic, EJ Cho, S F Stampfli, LE Sade, J Y Cho, CRLA Rocon, G Nucifora, M Astrom Aneq, I S Leren, A Zaroui, C Venturini, N Mansencal, L Caballero, AC Gomes, B Biernacka, I Ikonomidis, A Abreu, L Asmarats Serra, L Gargani, D Smith, F Ancona, C Devecchi, S Cersit, S Gunduz, R Rifai, B De Chiara, R Zilberszac, M Penicka, RM Soto-Ruiz, B Naratrekoon, L Reis, D Trifunovic, GJ Morgado, JM Ribeiro, F Antonini-Canterin, RA Spampinato, E Rodriguez Gonzalez, S A Nazir, VA Kuznetsov, S Leao, A Bouzas-Mosquera, R Cano Carrizal, OM Demir, JMG Fernandes, MM Michelsen, M Cantinotti, N Naksuk, S Moustafa, F Ferrara, G Klug, A S Gopal, OH Lie, C Basar, I Trunina, KL Hansen, PJ Carrero, M Madeira, PJ Howlett, A Angelis, M Pellegrino, P Barbier, A Garcia Martin, M Haberka, K Banska, Z Gasior, JL Moya-Mur, S-A Carbonell-San Roman, D Rodriguez-Munoz, A Garcia-Lledo, E Casas-Rojo, JJ Jimenez-Nacher, C Fernandez-Golfin, JL Zamorano-Gomez, A Ravani, C Cefalu, A Maltagliati, B Frigerio, D Sansaro, M Amato, D Baldassarre, F Bandera, G Generati, V Labate, E Alfonzetti, M Guazzi, K Aggeli, N Ioakeimidis, M Abdelrasoul, I Felekos, I Gourgouli, K Aznaouridis, G Rousakis, C Vlachopoulos, D Tousoulis, K Darasz, M Mahmoudi, N Shah, RI Jabr, M Hickman, EW Leatham, CH Fry, R Teixeira, I Almeida, F Caetano, A Fernandes, M Cassandra, M Costa, L Goncalves, AJ Nielsen, MC Carrero, GL Saubidet, SP Peralta, H Moeller-Soerensen, J Kjaergaard, MB Jensen, JT Lund, MM Pedersen, JB Olesen, JA Jensen, MB Nielsen, AS Sharykin, EV Karelina, ND Telezhnikova, H Ozhan, O Kayapinar, ES Albayrak, J Saberniak, L Dejgaard, T Edvardsen, KH Haugaa, U Bal, S Eroglu, B Pirat, H Muderrisoglu, L Muthukumar, SK Saha, RS Toole, S Reinstadler, HJ Feistritzer, B Pernter, A Mayr, WM Franz, S Mueller, B Metzler, S Mingo Santos, V Palomero Monivas, J Gonzalez Mirelis, J Goirigolzarri Artaza, B Zorita Gil, JA Fernandez Diaz, J Goicolea Ruigomez, MA Restrepo Cordoba, L Alonso Pulpon, M D'alto, S Ghio, E Acri, L Carannante, P Argiento, A D'andrea, O Vriz, E Bossone, TH Ho, P Shah, K Murphy, BK Nelluri, H Lee, S Wilansky, F Mookadam, T Peeraphatdit, R Chaiteerakij, KW Klarich, M Scalese, M Melo, N Assanta, M Marotta, M Crocetti, I Spadoni, R Giordano, S Kutty, I Iervasi, ND Mygind, A Pena, D Frestad, N Hoest, E Prescott, BO Romao, IR Rivera, MA Mendonca, AC Carvalho, O Campos, A Amato, VA Moises, A Bashir, K Marshall, M Douglas, B Wasan, S Plein, K Alfakih, C Casanova Rodriguez, R Cadenas Chamorro, D Iglesias Del Valle, A Martin-Penato Molina, J De Juan Baguda, E Prieto Moriche, A Garcia Garcia, E De La Cruz Berlanga, I Plaza Perez, J Peteiro, FJ Broullon, N Alvarez-Garcia, C Barbeito-Caamano, JM Larranaga-Moreira, N Maneiro-Melon, D Martinez-Ruiz, JC Yanez, JM Vazquez-Rodriguez, F Cordeiro, P Magalhaes, M Moz, J Trigo, P Mateus, P Fontes, I Moreira, DV Krinochkin, AV Plusnin, AM Soldatova, A Shetye, JN Khan, A Singh, P Kanagala, DJ Swarbrick, M Graham-Brown, GP Mccann, G Krljanac, L Savic, M Asanin, S Aleksandric, R Lasica, M Srdic, N Zlatic, M Petrovic, I Mrdovic, V Monivas Palomero, B Rivero Arribas, M Dobrovie, JG Da Rocha E Silva, F Bonamigo Thome, R Kluttig, V Schloma, Y Dmitrieva, E Strotdrees, FW Mohr, G Luzza, R Caruso, R Belfiore, A Della Mattia, S Poli, C Zito, S La Carrubba, S Carerj, JF Carvalho, D Caldeira, IR Cruz, B Stuart, R Maia, P Fazendas, H Pereira, I Rakocevic, V Tutos, O Petrovic, M Boricic-Kostic, J Stepanovic, I Jovanovic, M Banovic, B Vujisic-Tesic, L Leite, A Botelho, M Santos, J Nascimento, T Yingchoncharoen, P Vathesatogkit, S Yamwong, P Sritara, J C Bonaque Gonzalez, J Abellan-Huerta, R Rubio-Paton, F Soria, JL Ramos, S Egea, J Garcia-Gomez, JJ Martinez Diaz, JA Castillo, J Vecera, C Mirica, M Kotrc, R Kockova, H Gabriel, G Maurer, R Rosenhek, L Botta, F Musca, O Belli, A Costetti, I Trolese, F Spano, C Russo, C Giannattasio, A Moreo, E Berthelot, MT Le, L Hilpert, D Montani, O Sitbon, X Jais, M Humbert, P Assayag, M Yesin, M Kalcik, MO Gursoy, MA Astarcioglu, S Karakoyun, AC Aykan, M Ozkan, M Tabakci, E Bayam, A Degiovanni, MV Di Ruocco, P Marino, I Rosa, S Stella, M Barletta, C Marini, A Latib, M Montorfano, A Colombo, A Margonato, E Agricola, R Ray, M Gallagher, M Nazir, V Perreso, R Sharma, PS Pang, M Miglioranza, P Landi, FL Dini, E Picano, J Pons Llinares, F Macaya Ten, P Pericas Ramis, O Caldes Llull, A Grau Sepulveda, G Frontera, A Bethencourt, H Santa Clara, V Santos, M Oliveira, P Cunha, G Portugal, P Rio, L Branco, M Mota Carmo, I Paraskevaidis, C Papadopoulos, V Stasinos, J Parissis, J Lekakis, P Rubis, A Gackowski, S Wisniowska-Smialek, A Lesniak-Sobelga, M Kostkiewicz, D Bento, E Correia, L Teles, B Picarra, C Lourenco, R Faria, K Domingues, O Azevedo, V Climent Paya, M Martinez Moreno, JR Gimeno, MJ Oliva, D Saura, J Sanchez Quinones, A Garcia Honrubia, M Valdes, G De La Morena, P Richard, S Guerard, R Brion, P Paul, O Dubourg, M Komajda, R Isnard, M Arslan, P Charron, G Avegliano, S Andres, JP Costabel, P Kuschnir, A Sciancalepore, O Mendoza, G Perea, R Ronderos, RYM Ben Said, TEJ EL Chalbia, SANA Wali, MS Mourali, RACHID Mechmeche, TF Haland, J S Svetlichnaya, SS Shikha, MS Scheinmann, LK Klein, G Prati, G Vitrella, G Allocca, S Cukon Buttignoni, D Muser, G Morocutti, B Pinamonti, G Sinagra, A Proclemer, MDTM Melo, EAB Bocchi, JABAF Araujo, LMMFD Demarchi, CM Mady, BB Biselli, RKF Kalil, VMCS Salemi, RT Tuma, K H Kim, H J Yoon, K J Lee, H Park, J H Kim, Y Ahn, M H Jeong, J G Cho, J C Park, H J Park, H Kozan, A Sezgin, A Aydinalp, T Oezkartal, S Bernhart, AJ Flammer, A Vecchiati, GM Froehlich, F Ruschitzka, FC Tanner, KY Choi, DB Kim, SW Jang, JS Cho, HO Jung, HK Jeon, HJ Youn, M Dekleva, PRL Fortes, BR Passos, AB Rodrigues, IH Sampaio, MCN Oliveira, MG Silva, RAF Cardoso, FA Tofani, MCV Moreira, G Cioffi, O Viapiana, A Dalbeni, E Fracassi, C Di Nora, C Mazzone, A Di Lenarda, M Rossini, C Corros, A Garcia-Campos, M Martin, M Rodriguez-Suarez, V Leon, A Fidalgo, F Lopez-Iglesias, C Moris, JM De La Hera, R Dabrowski, J Wozniak, S Jasek, T Chwyczko, I Kowalik, E Musiej-Nowakowska, H Szwed, R Marinov, G Stamenov, M Mihova, K Chacheva, S Persenska, A Racheva, M Przewlocka-Kosmala, A Rojek, B Karolko, A Mysiak, TH Marwick, P Tittel, M Kardos, V Vrsanska, M Ondriska, V Hraska, M Nosal, J Masura, I Simkova, S Apostolovic, S Salinger-Martinovic, R Jankovic-Tomasevic, D Djordjevic-Radojkovic, T Stanojlovic, V Atanaskovic, M Pavlovic, E Tahirovic, HD Dungen, JL Moya Mur, C Lozano Granero, JJ Jimenez Nacher, A Gonzalez Gomez, C Fraile Sanz, T Segura De La Cal, JL Zamorano Gomez, WW Jansen Klomp, AWJ Van 'T Hof, GJ Brandon Bravo Bruinsma, AJ Spanjersberg, J Grandjean, AP Nierich, J Ferreira, S Lazaro Mendes, R Martins, S Monteiro, M Pego, R Khamene Bagheri, JZ Peruga, M Sobczak, M Plewka, T Wcislo, R Krecki, JD Kasprzak, G Morgado, I Cruz, AR Almeida, I Joao, L Lopes, C Cotrim, G Faganello, C Pandullo, G Russo, C Stefenelli, F Furlanello, L Tarantini, K Suzuki, Y Satoh, K Minami, K Mizukoshi, R Kamijima, S Kou, M Takai, M Izumo, YJ Akashi, J Ayuk, I Geh, T Shah, NC Edwards, RP Steeds, D Miskowiec, K Wdowiak-Okrojek, P Lipiec, M Rosca, A Calin, C Beladan, M Serban, C Ginghina, BA Popescu, M Lombardero, R Henquin, M Tinetti, G Hekimian, M Achkar, A Combes, N Hammoudi, M Al-Ghamdi, A Ghabashi, M H Ezzat, A Al-Amin, G Giraldeau, SI Sarvari, J Marin, C Brambila, L Gabrielli, B Bijnens, M Sitges, N Duchateau, T Erdei, A Fraser, B H Bijnens, G Piella, L Sanchis, R Borras, B Vidal, S Prat, M Azqueta, C Pare, G Grazioli, MH Jung, HS Ahn, JH Kim, A Megias, GL Alonso, A Gonzalez-Gomez, LM Rincon, A Esteban, MA Fernandez Mendez, V Barrios, JL Zamorano, L Van Gaal, C De Block, R Salgado, C Vrints, B Shivalkar, A Pereira, R Santos, L Marques, N Moreno, R Carvalho, M Pires, R Sousa, A Andrade, P Pinto, A Stoylen, D Fugelseth, O Tautu, S Onciul, C Marinescu, D Zamfir, M Dorobantu, V Sanchez Sanchez, P Navas, D Garcia-Cosio, B Diaz, L Carballo-Alzola, F Lombera, J Delgado, M Babcak, N Kishko, A Eitan, D Mutlak, I Kehat, AH Meretta, F Belcastro, E Aguirre, D Rosa, P Zaefferer, O Masoli, ES Srbinovska, MB Bosevski, EA Antova, DPG Pop Gorceva, M Martin Fernandez, SM Costilla Garcia, E Diaz Pelaez, and C Moris De La Tassa

Subjects
education.field_of_study, Multiple kernel learning, business.industry, Population, Diastole, Spec#, General Medicine, 030204 cardiovascular system & hematology, Machine learning, computer.software_genre, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Stress Echocardiography, Unsupervised learning, Radiology, Nuclear Medicine and imaging, Artificial intelligence, Cardiology and Cardiovascular Medicine, education, business, Heart failure with preserved ejection fraction, Isovolumetric contraction, computer, Mathematics, computer.programming_language
Abstract

Purpose: No consensus exists for the diagnosis of heart failure with preserved ejection fraction (HFPEF). Current studies recommend stress echocardiography protocols, but single standard peak or timing measurements are limited towards the complexity of the disease. We show the contribution of a combined analysis of multiple myocardial velocity patterns and investigate their relative relevance for the characterization of HFPEF. Methods: Velocity traces from 55 subjects were examined (69±6 years, 22 healthy, 19 HFPEF and 14 breathless subjects). Data came from tissue Doppler acquisitions at rest and exercise at the basal septum and lateral wall, and were temporally aligned to a common reference for comparison. Each phase of the cycle at each stage of the protocol was identified for analysis (figure). Unsupervised machine learning (multiple kernel learning) was used to characterize this population and automatically determine the relevance of each velocity pattern. Results: The learning found a discrimination algorithm that performed well in agreement with diagnosis based on current guidelines (sens=78.9%, spec=86.3%, K=0.65). The importance given to early diastole at exercise was substantially higher, while the isovolumic contraction was the lowest contributor. The breathless subjects were associated to their closest subgroup. Conclusion: The characterization of HFPEF is improved by a combined analysis of multiple velocity traces from stress echo studies using machine learning. The method additionally suggests features of interest to be used in clinical diagnosis.

Published
2015

9. Rapid Fire Abstract session: multimodality imaging of ischaemic heart disease928Regional left ventricular longitudinal function and myocardial blood flow929The influence of plaque burden, morphology and inflammatory markers on coronary microvascular function in patients with chest pain and unobstructed coronary arteries930Predictors of coronary microcirculatory function after primary percutaneous coronary intervention in STEMI patients932Prediction of adverse events after ST segment-elevation myocardial infarction by imaging techniques933Echocardiography, contractile reserve and magnetic resonance to predict left ventricular remodelling934Relationship between the morphology of myocardial infarction scar border assessed by cardiac magnetic resonance and the inducibility of ventricular tachycardia935Comprehensive echocardiographic long-term risk stratification for the prediction of heart failure hospitalization and cardiovascular death following ST-segment elevation myocardial infarction

Author

F J Olsen, N Hammache, S Rodero, D Trifunovic, K T Nel, L Faber, O Lindner, N Bogunovic, D Hering, W Burchert, D Horstkotte, R Senior, CM Anstey, J Begley, CD Byrne, J Kaski, R Bull, CJ Boos, K Greaves, S Stankovic, J Stepanovic, D Orlic, M Banovic, M Tesic, O Petrovic, M Petrovic, A Djordjevic-Dikic, B Vujisic-Tesic, M Mutuberria, J Rodriguez-Palomares, M Terricabras, L Gutierrez, G Teixido, L Galian, T Gonzalez-Alujas, A Evangelista, D Garcia-Dorado, D Voilliot, B Brembilla-Perrot, F Odille, J Felblinger, D Mandry, PY Marie, N Sadoul, O Huttin, C De Chillou, JS Jensen, SH Pedersen, K Nochioka, and T Biering-Sorensen

Subjects
Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine
Published
2015

10. Oral Abstract session: Different imaging modalities for the approach of coronary artery disease: Friday 5 December 2014, 16:30-18:00 * Location: Agora

Author

I. Jovanovic, M. Tesic, V. Giga, O. Petrovic, M. Petrovic, J. Stepanovic, D. Trifunovic, B. Vujisic-Tesic, B. Beleslin, A. Djordjevic-Dikic, S. E. Petersen, T. Genders, F. Pugliese, A. Dastidar, K. Fleischmann, K. Nieman, M. Hunink, M. Cameli, M. Lisi, F. Righini, S. Sparla, C. Di Tommaso, S. Lunghetti, M. Galderisi, S. Mondillo, N. Boskovic, I. Paunovic, J. Kostic, M. Dobric, A. Vilela, J. Assef, R. Barretto, D. Le Bihan, W. Melchior, R. Ramos, E. Santos, A. Souza, D. Voilliot, F. Odille, D. Mandry, O. Huttin, M. Andronache, P. Marie, J. Felblinger, E. Aliot, N. Sadoul, C. De Chillou, K. Liou, S. Ho, G. Cranney, S. Ooi, M. Carminati, C. Boniotti, G. Pontone, D. Andreini, M. Pepi, and E. Caiani

Subjects
medicine.medical_specialty, business.industry, General surgery, General Medicine, medicine.disease, Imaging modalities, Coronary artery disease, Medicine, Radiology, Nuclear Medicine and imaging, Agora, Session (computer science), Cardiology and Cardiovascular Medicine, business, computer, computer.programming_language
Published
2014

12. Poster Session 1: Thursday 8 December 2011, 08:30-12:30 * Location: Poster Area

Author

S. Vijayan, M. Khanji, A. Ionescu, C. Podoleanu, A. Frigy, A. Ugri, A. Varga, D. Podoleanu, A. Incze, E. Carasca, D. Dobreanu, O. Mjolstad, H. Dalen, T. Graven, J. Kleinau, B. Hagen, H. Fu, T. Liu, J. Li, C. Liu, C. Zhou, G. Li, R. Bordese, M. Capriolo, D. Brero, I. Salvetti, M. Cannillo, M. Antolini, W. Grosso Marra, S. Frea, M. Morello, F. Gaita, F. Maffessanti, E. Caiani, D. Muraru, F. Tuveri, L. Dal Bianco, L. Badano, A. Majid, A. Soesanto, B. Ario Suryo Kuncoro, R. Sukmawan, M. H. Ganesja, T. Benedek, M. Chitu, J. Beata, Z. Suciu, I. Kovacs, O. Bucur, I. Benedek, A. Hrynkiewicz-Szymanska, F. Szymanski, G. Karpinski, K. Filipiak, Z. Radunovic, L. Lande Wekre, K. Steine, O. Bech-Hanssen, B. Rundqvist, F. Lindgren, N. Selimovic, J. Jedrzychowska-Baraniak, R. Jozwa, B. Larysz, J. Kasprzak, T. Ripp, V. Mordovin, E. Ripp, A. Ciobanu, R. Dulgheru, R. Dragoi, S. Magda, M. Florescu, S. Mihaila, R. Rimbas, M. Cinteza, D. Vinereanu, C. Benavides-Vallve, B. Pelacho, O. Iglesias, S. Castano, A. Munoz-Barrutia, F. Prosper, C. Ortiz De Solorzano, A. Manouras, A. Sahlen, R. Winter, P. Vardas, L. Brodin, S. I. Sarvari, K. H. Haugaa, W. Zahid, B. Bendz, L. Aaberge, T. Edvardsen, G. Di Bella, S. Pedri, R. Donato, A. Madaffari, C. Zito, D. Stapf, M. Schreckenberg, S. Carerj, H. Yoshikawa, M. Suzuki, Y. Kusunose, G. Hashimoto, T. Otsuka, M. Nakamura, K. Sugi, J. Grapsa, D. Dawson, W. Gin-Sing, L. Howard, J. Gibbs, P. Nihoyannopoulos, B. Smith, T. Coulter, A. Rendon, W. Gorissen, A. Shiran, I. Asmer, S. Adawi, M. Ganaeem, J. Shehadeh, M. Cameli, M. Lisi, F. Righini, M. Maccherini, G. Sani, M. Galderisi, S. Mondillo, D. Kalimanovska-Ostric, T. Nastasovic, I. Jovanovic, B. Milakovic, M. Dostanic, M. Stosic, I. Sasic, K. Sveen, T. Nerdrum, K. Hanssen, K. Dahl-Jorgensen, E. Holte, J. Vegsundvaag, T. Hole, K. Hegbom, R. Wiseth, I. Ikonomidis, J. Lekakis, V. Tritakis, I. Papadakis, N. Kadoglou, S. Tzortzis, P. Trivilou, C. Koukoulis, I. Paraskevaidis, M. Anastasiou-Nana, M. K. Smedsrud, S. Sarvari, O. Gjesdal, M. Beraldo, E. Solda', U. Cucchini, D. Peluso, M. Tuveri, A. Al Mamary, S. Iliceto, H. Dores, J. Abecasis, M. Carvalho, M. Santos, M. Andrade, R. Ribeiras, C. Reis, E. Horta, R. Gouveia, M. Mendes, D. Zaliaduonyte-Peksiene, V. Mizariene, G. Cesnaite, E. Tamuleviciute, R. Jurkevicius, J. Vaskelyte, R. Zaliunas, K. Smarz, B. Zaborska, T. Jaxa-Chamiec, P. Maciejewski, A. Budaj, D. Trifunovic, D. Sobic-Saranovic, S. Stankovic, M. Ostojic, B. Vujisic-Tesic, M. Petrovic, I. Nedeljkovic, M. Banovic, M. Tesic, I. Petrovic, I. Peovska, E. Srbinovska, J. Maksimovic, V. Andova, F. Arnaudova, E. Hristova, M. Otljanska, M. Vavlukis, S. Jovanova, G. Tamborini, L. Fusini, P. Gripari, M. Muratori, G. Pontone, D. Andreini, E. Bertella, S. Ghulam Ali, A. Bartorelli, M. Pepi, M. Cusma-Piccione, J. Salvia, F. Antonini-Canterin, S. Lentini, D. Donato, M. Miceli, G. Oreto, R. Sachner, R. Rubinshtein, M. Shnapp, T. Gaspar, A. Marchese, W. Deste, A. Sanfilippo, P. Aruta, M. Patane, G. Millan, G. Ussia, C. Tamburino, V. Kujacic, S. Obradovic, Z. Crkvenac, A. Bernard, M. Piquemal, G. Muller, P. Arbeille, B. Charbonnier, C. Broyd, J. Davies, G. Mikhail, J. Mayet, D. Francis, M. Rosca, J. Magne, C. Szymanski, B. Popescu, C. Ginghina, L. Pierard, P. Lancellotti, A. Gonzalez-Mansilla, J. Solis, R. Angulo, E. Perez-David, G. Madrid, J. Garcia-Robles, R. Yotti, R. Prieto, J. Bermejo, F. Fernandez-Aviles, Y. Ishikawa, T. Ishida, T. Osaki, M. Matsuyama, H. Yamashita, S. Ozaki, M. Stevanella, E. Votta, F. Veronesi, F. Alamanni, A. Redaelli, S. D. Park, J. Lee, S. Shin, S. Woo, D. Kim, K. Park, J. Kwan, W. Tsang, S. Chandra, L. Weinert, E. Gayat, M. Djelassi, T. Balbach, V. Mor-Avi, R. Lang, P. De Meester, A. Van De Bruaene, M. Delcroix, W. Budts, L. Abid, Z. Frikha, K. Makni, H. Rekik, A. Znazen, H. Mourad, S. Kammoun, L. Sargento, M. Satendra, C. Sousa, S. Lopes, S. Longo, N. Lousada, R. Palma Reis, D. Fouad, R. Shams Eldeen, C. Beladan, A. Calin, F. Voinea, R. Enache, R. Jurcut, I. Coman, M. Ghionea, A. Djordjevic-Dikic, O. Petrovic, M. Boricic, V. Giga, L. Pisciella, C. Lanzillo, M. Minati, S. Caselli, M. Di Roma, S. Fratini, S. Romano, L. Calo', E. Lioy, M. Penco, G. Finocchiaro, B. Pinamonti, M. Merlo, G. Barbati, G. Sinagra, A. Dilenarda, S. Comenale Pinto, R. Ancona, P. Caso, C. Cavallaro, F. Vecchione, A. D'onofrio, M. Fero', R. Calabro', S. Gustafsson, E. Ihse, M. Henein, P. Westermark, O. Suhr, P. Lindqvist, M. Oliva Sandoval, M. Gonzalez Carrillo, M. Garcia Navarro, E. Garcia-Molina Saez, M. Sabater Molina, D. Saura Espin, J. Lacunza Ruiz, J. Gimeno Blanes, G. De La Morena Valenzuela, M. Valdes Chavarri, C. Prinz, L. Faber, D. Horstkotte, H. Hoetz, J. Voigt, F. Gandara, M. Correia, I. Rosario, C. Fonseca, I. Arroja, A. Aleixo, A. Martins, L. Radulescu, D. Dan Radulescu, P. Parv Andreea, D. Duncea Caius, C. Ciuleanu T, M. Mitrea Paulina, F. Cali Quaglia, M. Ribezzo, M. Boffini, M. Rinaldi, A. M. Maceira Gonzalez, J. Cosin-Sales, E. Dalli, J. Diago, J. Aguilar, J. Ruvira, S. Goncalves, A. Gomes, F. Pinto, W.-C. Tsai, Y.-W. Liu, J.-Y. Shih, Y.-Y. Huang, J.-Y. Chen, L.-M. Tsai, J.-H. Chen, S. Ribeiro, D. Doroteia, L. Santos, C. David, G. Vinhas De Sousa, A. Almeida, M. Iwase, Y. Itou, S. Yasukochi, K. Shiino, H. Inuzuka, K. Sugimoto, Y. Ozaki, K. Gieszczyk-Strozik, A. Sikora-Puz, M. Mizia, B. Lasota, A. Chmiel, A. Lis-Swiety, J. Michna, L. Brzezinska-Wcislo, K. Mizia-Stec, Z. Gasior, P. Luijendijk, H. De Bruin-Bon, C. Zwiers, J. Vriend, R. Van Den Brink, B. Mulder, B. Bouma, S. Brigido, P. Gianfagna, A. Proclemer, B. Plicht, P. Kahlert, H. Kaelsch, T. Buck, R. Erbel, T. Konorza, H. Yoon, K. Kim, Y. Ahn, M. Jeong, J. Cho, J. Park, J. Kang, W. Rha, W. W. Jansen Klomp, G. Brandon Bravo Bruinsma, A. Van 'T Hof, S. Spanjersberg, A. Nierich, T. Bombardini, S. Gherardi, E. Picano, A. Ciarka, L. Herbots, E. Eroglu, J. Van Cleemput, W. Droogne, R. Jasityte, B. Meyns, J. D'hooge, J. Vanhaecke, M. Al Barjas, R. Iskreva, R. Morris, J. Davar, Y. Zhao, A. Holmgren, S. Morner, J. Stepanovic, B. Beleslin, M. Nedeljkovic, S. Mazic, V. Stojanov, R. Piatkowski, J. Kochanowski, P. Scislo, M. Grabowski, M. Marchel, M. Roik, D. Kosior, G. Opolski, A. Tomaszewski, A. Kutarski, M. Tomaszewski, S. Eibel, E. Hasheminejad, C. Mukherjee, H. Tschernich, J. Ender, I. Delithanasis, J. Celutkiene, C. Kenny, M. Monaghan, S. Van Den Oord, G. Ten Kate, Z. Akkus, G. Renaud, E. Sijbrands, F. Ten Cate, N. De Jong, J. Bosch, A. Van Der Steen, A. Schinkel, A. Lisowska, M. Knapp, A. Tycinska, R. Sawicki, P. Kralisz, B. Sobkowicz, S.-A. Chang, S.-C. Lee, E.-Y. Kim, S.-H. Hahm, G.-T. Ahn, M.-K. Sohn, S.-J. Park, J.-O. Choi, S.-W. Park, J.-K. Oh, M. O. Gursoy, T. Gokdeniz, M. Astarcioglu, Z. Bayram, B. Cakal, S. Karakoyun, M. Kalcik, G. Kahveci, M. Yildiz, M. Ozkan, V. Skidan, A. Borowski, M. Park, J. Thomas, S. Ranjbar, S. Hassantash, M. Karvandi, M. Foroughi, E. S. Davidsen, D. Cramariuc, O. Bleie, E. Gerdts, K. Matre, M. Cusma' Piccione, G. Bagnato, M. Mohammed, S. Piluso, L. Oreto, T. Bitter, S. Carvalho, M. Canada, M. Santisteban Sanchez De Puerta, M. D. Mesa Rubio, M. Ruiz Ortiz, M. Delgado Ortega, M. L. Pena Pena, M. Puentes Chiachio, J. Suarez De Lezo Cruz-Conde, M. Pan Alvarez-Ossorio, F. Mazuelos Bellido, J. Suarez De Lezo Herreros De Tejada, E. Altekin, A. Yanikoglu, S. Karakas, C. Oncel, B. Akdemir, A. Belgi Yildirim, A. Cilli, H. Yilmaz, L. Lenartowska, M. Furdal, B. Knysz, A. Konieczny, J. Lewczuk, S. Severino, M. Cavallaro, M. Coppola, H. Motoki, A. To, M. Bhargava, O. Wazni, T. Marwick, A. Klein, E. Sinkovskaya, S. Horton, A. Abuhamad, S. Mingo Santos, V. Monivas Palomero, B. Beltran Correas, C. Mitroi, C. Gutierrez Landaluce, I. Garcia Lunar, J. Gonzalez Mirelis, M. Cavero, J. Segovia Cubero, L. Alonso Pulpon, E. Gurel, T. Karaahmet, K. Tigen, C. Kirma, C. Dundar, S. Pala, I. Isiklar, C. Cevik, A. Kilicgedik, Y. Basaran, M. Brambatti, A. Romandini, A. Barbarossa, S. Molini, A. Urbinati, A. Giovagnoli, L. Cipolletta, A. Capucci, S. Park, E. Choi, C. Ahn, S. Hong, M. Kim, D. Lim, W. Shim, J. Xie, F. Fang, Q. Zhang, J. Chan, G. Yip, J. Sanderson, Y. Lam, B. Yan, C. Yu, P. Jorge Perez, A. De La Rosa Hernandez, C. Hernandez Garcia, A. Duque Garcia, A. Barragan Acea, E. Arroyo Ucar, J. Jimenez Rivera, J. Lacalzada Almeida, I. Laynez Cerdena, C. Carminati, R. Capoulade, E. Larose, M. Clavel, J. Dumesnil, M. Arsenault, E. Bedard, P. Mathieu, P. Pibarot, L. Gargani, G. Baldi, F. Forfori, D. Caramella, L. D'errico, A. Abramo, R. Sicari, F. Giunta, W.-N. Lee, B. Larrat, E. Messas, M. Pernot, M. Tanter, V. Velagic, M. Cikes, R. Matasic, I. Skorak, J. Samardzic, D. Puljevic, M. Lovric Bencic, B. Biocina, D. Milicic, B. Roosens, G. Bala, S. Droogmans, J. Hostens, J. Somja, E. Delvenne, J. Schiettecatte, T. Lahoutte, G. Van Camp, B. Cosyns, A. Ghosh, R. Hardy, N. Chaturvedi, J. Deanfield, D. Pellerin, D. Kuh, A. Hughes, A. Malmgren, M. Dencker, M. Stagmo, P. Gudmundsson, Y. Seo, T. Ishizu, K. Aonuma, M. J. Schuuring, J. Vis, A. Van Dijk, J. Van Melle, P. Pieper, H. Vliegen, G. Sieswerda, E. Foukarakis, A. Pitarokilis, P. Kafarakis, A. Kiritsi, E. Klironomos, A. Manousakis, X. Fragiadaki, E. Papadakis, and A. Dermitzakis

Subjects
medicine.medical_specialty, business.industry, Thursday, medicine, Radiology, Nuclear Medicine and imaging, Medical physics, General Medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business, Surgery
Published
2011

13. Poster session I * Thursday 9 December 2010, 08:30-12:30

Author

V. A. Kuznetsov, A. O. Kozhurina, A. V. Plusnin, M. Szulik, B. Sredniawa, W. Streb, R. Lenarczyk, J. Stabryla-Deska, A. Sedkowska, O. Kowalski, Z. Kalarus, T. Kukulski, T. M. Katova, A. Nesheva, I. Simova, K. Hristova, V. Kostova, L. Boiadjiev, N. Dimitrov, M. P. Papamichalis Michalis, S. G. Sitafidis George, B. D. Dimopoulos Basilios, G. K. Kelepesis Glafkos, D. E. Economou Dimitrios, J. S. Skoularigis John, F. T. Triposkiadis Filippos, C. H. Attenhofer Jost, M. Pfyffer, B. Naegeli, P. Levis, A. Faeh-Gunz, H. P. Brunner-Larocca, M. S. Velasco Del Castillo, A. Cacicedo, J. J. Onaindia, J. Gonzalez Ruiz, A. Subinas, J. A. Alarcon, O. Quintana, I. Rodriguez, E. Laraudogoitia, Y.-Y. Lam, M. Y. Henein, A. Mazzone, A. Vianello, S. Perlini, A. I. Corciu, S. Cappelli, A. Cerillo, D. Chiappino, S. Berti, M. Glauber, S. Herrmann, M. Niemann, S. Stoerk, J. Strotmann, W. Voelker, G. Ertl, F. Weidemann, Z. Y. Yong, K. Boerlage - Van Dijk, K. T. Koch, M. M. Vis, B. J. Bouma, J. P. S. Henriques, R. Cocchieri, B. A. J. M. De Mol, J. J. Piek, J. Baan, N. G. J. Keenan, C. Cueff, C. Cimadevilla, E. Brochet, L. Lepage, D. Detaint, B. Iung, A. Vahanian, D. Messika-Zeitoun, T. Otsuka, M. Suzuki, H. Yoshikawa, G. Hashimoto, T. Osaki, T. Tsuchida, M. Matsuyama, H. Yamashita, S. Ozaki, K. Sugi, C. J. Garcia Alonso, N. Vallejo Camazon, E. Ferrer Sistach, M. L. Camara, J. Lopez Ayerbe, C. Bosch Carabante, M. Espriu Simon, F. Gual Capllonch, A. Bayes Genis, G. Deswarte, C. Vanesson, A. S. Polge, D. Huchette, T. Modine, P. Marboeuf, N. Lamblin, C. Bauters, G. Deklunder, T. Le Tourneau, A. Agricola, M. Gullace, S. Stella, R. D'amato, M. Slavich, M. Oppizzi, M. Ancona, A. Margonato, F. Le Ven, Y. Etienne, Y. Jobic, I. Frachon, P. Castellant, M. Fatemi, J. J. Blanc, M. Muratori, P. Montorsi, F. Maffessanti, P. Gripari, G. Teruzzi, S. Ghulam Ali, L. Fusini, F. Celeste, M. Pepi, B. Goebel, K. Haugaa, K. Meyer, S. Otto, A. Lauten, C. Jung, T. Edvardsen, H. R. Figulla, T. C. Poerner, H. Aksoy, S. Okutucu, B. Evranos, K. Aytemir, E. B. Kaya, G. Kabakci, L. Tokgozoglu, H. Ozkutlu, A. Oto, N. Valeur, H. H. Pedersen, R. Videbaek, C. Hassager, J. H. Svendsen, L. Kober, M. K. Tigen, T. Karaahmet, E. Gurel, S. Pala, C. Dundar, Y. Basaran, C. I. Caldararu, E. Ene, M. Dorobantu, R. G. Vatasescu, M. Cikes, B. Bijnens, H. Gasparovic, F. Siric, V. Velagic, D. Lovric, J. Samardzic, B. Ferek-Petric, D. Milicic, B. Biocina, J. Kjaergaard, S. Ghio, M. St John Sutton, O. Moreau, G. Kervio, C. Thebault, C. Leclercq, E. Donal, C. Mornos, D. Rusinaru, L. Petrescu, D. Cozma, A. Ionac, S. Pescariu, S. I. Dragulescu, M. Z. Petrovic, B. Vujisic-Tesic, G. Milasinovic, M. T. Petrovic, I. Nedeljkovic, D. Zamaklar-Trifunovic, Z. Calovic, V. Jelic, M. Boricic, I. Petrovic, P. Kuchynka, T. Palecek, S. Simek, E. Nemecek, J. Horak, D. Hulinska, J. Schramlova, I. Vitkova, V. Aster, A. Linhart, L. Paluszkiewicz, D. Guersoy, S. Ozegowski, S. Spiliopoulos, R. Koerfer, G. Tenderich, M. Gaggl, G. Heinze, G. Sunder-Plassmann, S. Graf, M. Zehetmayer, T. Voigtlaender, C. Mannhalter, E. Paschke, G. Fauler, G. Mundigler, M. Tesic, D. Trifunovic, A. Djordjevic-Dikic, O. Petrovic, M. Petrovic, B. Beleslin, M. Ostojic, G. Draganic, C. E. Correia, B. Rodrigues, L. F. Santos, D. Moreira, P. Gama, L. Nunes, C. Nascimento, O. Dionisio, O. Santos, C. Prinz, O. Oldenburg, T. Bitter, C. Piper, D. Horstkotte, L. Faber, A. Nemes, H. Gavaller, M. Csanady, T. Forster, M. Calcagnino, C. O'mahony, K. Tsovolas, P. D. Lambiase, P. Elliott, A. S. Olezac, A. Bensaid, J. Nahum, E. Teiger, J. L. Dubois-Rande, P. Gueret, P. Lim, C. Langer, M. Kansal, P. Surapaneni, P. P. Sengupta, S. J. Lester, S. R. Ommen, S. W. Ressler, R. T. Hurst, V. Monivas Palomero, S. Mingo Santos, C. Mitroi, I. Garcia Lunar, P. Garcia Pavia, J. Gonzalez Mirelis, L. Ruiz Bautista, V. Castro Urda, J. Toquero Ramos, I. Fernandez Lozano, A. Sommer, S. H. Poulsen, J. Mogensen, L. Thuesen, H. Egeblad, R. Montisci, M. Ruscazio, A. Vacca, P. Garau, F. Tuveri, C. Soro, A. Matthieu, L. Meloni, W. Kosmala, M. Przewlocka-Kosmala, A. Wojnalowicz, A. Mysiak, T. H. Marwick, R. Yotti, C. Ripoll, J. Bermejo, Y. Benito, T. Mombiela, D. Rincon, A. Barrio, R. Banares, F. Fernandez-Aviles, A. Tomaszewski, A. Kutarski, M. Tomaszewski, R. Ticulescu, O. Vriz, L. Sparacino, B. A. Popescu, C. Ginghina, G. L. Nicolosi, S. Carerj, F. Antonini-Canterin, E. Agricola, L. Bertoglio, G. Melissano, R. Chiesa, S. Garcia Blas, D. Iglesias Del Valle, T. Lopez Fernandez, J. J. Gomez De Diego, M. C. Monedero Martin, F. J. Dominguez, M. Moreno Yanguela, J. L. Lopez Sendon, S. Adhya, F. D. Murgatroyd, M. Monaghan, L. Spinarova, J. Meluzin, P. Hude, J. Krejci, H. Podrouzkova, M. Pesl, R. Panovsky, L. Dusek, M. Orban, J. Korinek, C. Hammerstingl, M. Schwiekendik, G. Nickenig, D. Momcilovic, L. Lickfett, C. C. Beladan, A. Calin, M. Rosca, D. Muraru, F. Voinea, E. Popa, F. Matei, F. Curea, G. Di Salvo, G. Pacileo, S. Gala, B. Castaldi, A. F. D'aiello, A. Mormile, L. Baldini, M. G. Russo, R. Calabro, P. S. Halvorsen, G. Dahle, J. F. Bugge, B. Bendz, L. Aaberge, K. A. Rein, A. Fiane, J. Bergsland, E. Fosse, S. Aakhus, L. P. Koopman, N. Chahal, C. Slorach, W. Hui, T. Sarkola, C. Manlhiot, T. J. Bradley, E. T. Jaeggi, B. W. Mccrindle, L. Mertens, F. A. D'aiello, A. Mormilw, A. Rea, K. O'Connor, G. Romano, J. Magne, L. Pierard, P. Lancellotti, T. Arita, K. Ando, A. Isotani, Y. Soga, M. Iwabuchi, M. Nobuyoshi, M. Wiesen, D. Skowasch, F. Breunig, M. Beer, K. Hu, C. Wanner, M. A. Morel, Y. F. Bernard, V. Descotes-Genon, N. Meneveau, F. Schiele, A. Vitarelli, M. Bernardi, A. Scarno, F. Caranci, V. Padella, O. Dettori, L. Capotosto, M. Vitarelli, V. De Cicco, P. Bruno, G. Bajraktari, P. Lindqvist, U. Gustafsson, A. Holmgren, M. Hassan, K. Said, E. Baligh, H. Farouk, D. Osama, M. F. Elmahdy, A. Elfaramawy, K. Sorour, M. Luckie, A. Zaidi, A. Fitzpatrick, R. S. Khattar, J. Schwartz, O. Huttin, B. Popovic, P. Y. Zinzius, C. Christophe, O. Marcon, L. Groben, Y. Juilliere, F. Chabot, C. Selton-Suty, B. Krastev, E. T. K. Kinova, N. I. Z. Zlatareva, A. R. G. Goudev, A. J. Teske, B. W. De Boeck, F. A. Mohames Hoesein, V. Van Driel, P. Loh, M. J. Cramer, P. A. Doevendans, F. Dillenburg, K. M. Abd El Salam, E. M. M. Ho, M. Hall, L. Hemeryck, K. Bennett, K. Scott, G. King, R. T. Murphy, A. Mahmud, A. S. Brown, H. Dalen, A. Thorstensen, P. R. Romundstad, S. A. Aase, A. Stoylen, L. Vatten, T. Bochenek, K. Wita, Z. Tabor, A. Doruchowska, M. Lelek, M. Trusz-Gluza, E. Hamodraka, I. Paraskevaidis, A. Karamanou, C. Michalakeas, H. Vrettou, E. Kapsali, D. Tsiapras, I. Lekakis, M. Anastasiou-Nana, D. Kremastinos, L. Sirugo, V. E. Bottari, S. Licciardi, A. Blundo, A. Atanasio, I. P. Monte, C. S. Park, J. H. Kim, J. S. Cho, M. J. Kim, E. J. Cho, S. H. Ihm, H. O. Jung, H. K. Jeon, H. J. Youn, K. S. Kim, A. Fontana, L. Taravella, A. Zambon, G. Trocino, C. Giannattasio, A. Kalinin, M. Alekhin, G. Bahs, A. Lejnieks, A. Kalvelis, A. Kalnins, P. Shipachovs, E. Zakharova, G. Blumentale, M. Trukshina, T. Biering-Sorensen, R. Mogelvang, S. Haahr-Pedersen, P. Schnohr, P. Sogaard, J. Skov Jensen, L. Gargani, G. Agoston, E. Capati, L. Badano, A. Moreo, M. F. Costantino, M. L. Caputo, S. Mondillo, R. Sicari, E. Picano, E. G. Malev, E. V. Timofeev, S. V. Reeva, E. V. Zemtsovsky, R. Piazza, R. Enache, A. Roman-Pognuz, E. Leiballi, R. Pecoraro, H. Sadeghian, M. Lotfi_Tokaldany, M. Rezvanfard, A. Kasemisaeid, S. Majidi, M. Montazeri, M. Saber-Ayad, Y. S. Nassar, A. Farhan, A. Moussa, A. El-Sherif, R. M. Cooper, J. D. Somauroo, R. E. Shave, K. L. Williams, J. Forster, C. George, T. Bett, D. C. Gaze, K. P. George, N. Mansencal, A. Dupland, V. Caille, S. Perrot, K. Bouferrache, A. Vieillard-Baron, R. Jouffroy, S. G. Cioroiu, O. S. Alexe, E. Bobescu, H. Rus, V. Schiano Lomoriello, R. Esposito, A. Santoro, R. Raia, F. Farina, R. Ippolito, M. Galderisi, E. H. Aburawi, P. Malcus, A. Thuring, A. Maxedius, E. Pesonen, S. V. Nair, E. Joyce, L. Lee, J. Shrimpton, E. Newman, P. R. James, C. Jurcut, S. Caraiola, R. O. Jurcut, S. Giusca, D. Nitescu, M. S. Amzulescu, I. Copaci, C. Tanasescu, J. Silva Marques, D. Silva, F. Ferreira, P. C. Ferreira, A. G. Almeida, J. Martim Martins, M. G. Lopes, L. Bergenzaun, M. Chew, A. Ersson, P. Gudmundsson, H. Ohlin, A. Borowiec, R. Dabrowski, J. Wozniak, S. Jasek, T. Chwyczko, I. Kowalik, E. Musiej-Nowakowska, H. Szwed, Y. L. Wen, J. Tian, L. Yan, H. Cheng, H. Yang, B. Luo, J. Wang, H. Kozman, D. Villarreal, K. Liu, A. Karavidas, D. Tsiachris, G. Lazaros, V. Matzaraki, G. Xylomenos, G. Levendopoulos, S. Arapi, A. Perpinia, E. Matsakas, V. Pyrgakis, Y. W. Liu, C. T. Su, W. C. Tsai, J. W. Huang, K. Y. Hung, J. H. Chen, M. Larsson, F. Kremer, T. Kouznetsova, A. Bjallmark, B. Lind, L.-A. Brodin, J. D'hooge, M. Caputo, G. Antonelli, M. Lisi, E. Giacomin, S. Moustafa, M. Alharthi, Y. Deng, K. Chandrasekaran, F. Mookadam, S. Y. Hayashi, M. M. Nascimento, B. Lindholm, A. Seeberger, J. Nowak, M. C. Riella, L. A. Brodin, A. Theodosis, E. Fousteris, G. Tsiaousis, A. Krommydas, P. Margetis, Z. Katidis, D. Beldekos, S. Argirakis, A. Melidonis, S. Foussas, O. Khaleva, O. Onyshchenko, E. Lukaschuk, N. Sherwi, N. Nikitin, J. G. F. Cleland, N. Risum, C. Jons, N. T. Olsen, M. B. Kronborg, M. T. Jensen, T. Fritz-Hansen, N. E. Bruun, M. V. Hojgaard, J. Petrini, M. Yousry, A. Rickenlund, J. Liska, A. Franco-Cereceda, A. Hamsten, P. Eriksson, K. Caidahl, M. J. Eriksson, N. Elmstedt, K. Ferm-Widlund, M. Westgren, E. Szymczyk, J. D. Kasprzak, B. Wozniakowski, A. Rotkiewicz, K. Szymczyk, L. Stefanczyk, B. Michalski, P. Lipiec, L. Ring, T. Eller, P. Deegan, R. Rusk, J. A. Urbano Moral, J. A. Arias, J. T. Kuvin, A. R. Patel, N. G. Pandian, H. Bellsham-Revell, A. J. Bell, O. Miller, G. F. Greil, J. Simpson, R. Ancona, S. Comenale Pinto, P. Caso, S. Severino, L. Nunziata, T. Roselli, C. Dussault, S. Lafitte, G. Habib, P. Reant, G. Derumeaux, H. Thibault, A. Kaladaridis, I. A. Agrios, C. P. Pamboucas, S. M. Mesogitis, N. V. Vasiladiotis, D. B. Bramos, S. T. T. Toumanidis, A. R. Martiniello, G. Santangelo, G. Pedrizzetti, G. Tonti, C. Cioppa, M. Cavallaro, V. Calvi, and R. Chianese

Subjects
Speckle pattern, Longitudinal strain, business.industry, Carotid arteries, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine, business, Tracking (particle physics), Biomedical engineering
Abstract

Radial and longitudinal strain assessment in the carotid artery wall using speckle tracking

Published
2010

14. Poster session II * Thursday 9 December 2010, 14:00-18:00

Author

P. A. Pabari, A. Kyriacou, M. Moraldo, B. Unsworth, R. Baruah, N. Sutaria, A. Hughes, J. Mayet, D. P. Francis, T. Uejima, K. Loboz, F. Antonini-Canterin, C. Polombo, S. Carerj, D. Vinereanu, A. Evangelista, G. Leftheriotis, A. G. Fraser, A. Kiotsekoglou, M. Govindan, S. C. Govind, S. K. Saha, A. J. Camm, P. M. Azcarate, S. Castano, M. Rodriguez-Manero, M. Arraiza, B. Levy, J. Barba, G. Rabago, G. Bastarrika, A. Nemes, R. Takacs, T. Varkonyi, H. Gavaller, I. Baczko, T. Forster, T. Wittmann, J. G. Papp, C. Lengyel, A. Varro, L. R. Tumasyan, K. G. Adamyan, O. Savu, T. Mieghem, P. Dekoninck, L. Gucciardo, R. Jurcut, S. Giusca, B. A. Popescu, C. Ginghina, J. Deprest, J. U. Voigt, M. Versiero, M. Galderisi, R. Esposito, A. Rapacciuolo, G. Esposito, R. Raia, T. Morgillo, F. Piscione, G. De Simone, M. A. Oraby, F. A. Maklady, E. M. Mohamed, A. Z. Eraki, D. Zaliaduonyte-Peksiene, E. Tamuleviciute, J. Janenaite, J. Marcinkeviciene, V. Mizariene, S. Bucyte, J. Vaskelyte, D. Trifunovic, I. Nedeljkovic, D. Popovic, M. Ostojic, B. Vujisic-Tesic, M. Petrovic, S. Stankovic, D. Sobic-Saranovic, M. Banovic, A. Dikic-Djordjevic, K. Savino, A. Lilli, E. Grikstaite, V. Giglio, E. Bordoni, G. Maragoni, C. Cavallini, G. Ambrosio, B. Jakovljevic, B. Beleslin, M. Nedeljkovic, O. Petrovic, S. Moral, J. Rodriguez-Palomares, M. Descalzo, G. Marti, V. Pineda, P. Mahia, L. Gutierrez, T. Gonzalez-Alujas, D. Garcia-Dorado, F. Schnell, E. Donal, C. Thebault, A. Bernard, H. Corbineau, H. Le Breton, J. Kochanowski, P. Scislo, R. Piatkowski, M. Roik, M. Marchel, D. Kosior, G. Opolski, A. M. Lesniak-Sobelga, E. Wicher-Muniak, M. Kostkiewicz, M. Olszowska, E. Suchon, P. Klimeczek, P. Banys, M. Pasowicz, W. Tracz, P. Podolec, A. Laynez, D. E. Hoefsten, B. B. Loegstrup, B. Norager, J. E. Moller, A. Flyvbjerg, K. Egstrup, W. Streb, M. Szulik, J. Nowak, E. Markowicz-Pawlus, A. Duszanska, A. Sedkowska, Z. Kalarus, T. Kukulski, L. Spinelli, C. Morisco, E. Assante Di Panzillo, F. Buono, S. Crispo, B. Trimarco, A. A. Hawary, G. M. Nasr, M. M. Fawzy, L. Faber, W. Scholtz, J. Boergermann, M. Wiemer, G. Kleikamp, N. Bogunovic, Z. Dimitriadis, J. Gummert, D. Hering, D. Horstkotte, F. Luca', S. Gelsomino, R. Lorusso, S. Caciolli, R. Carella, G. Bille', G. De Cicco, V. Pazzagli, G. F. Gensini, A. Borowiec, R. Dabrowski, J. Janas, A. Kraska, B. Firek, I. Kowalik, H. Szwed, K. A. Marcus, C. L. De Korte, T. Feuth, J. M. Thijssen, L. Kapusta, J. Dahl, L. Videbaek, M. K. Poulsen, P. A. Pellikka, K. Veien, L. I. Andersen, T. Haghfelt, M. Haberka, K. Mizia - Stec, T. Adamczyk, M. Mizia, A. Chmiel, P. Pysz, M. Sosnowski, Z. Gasior, M. Trusz - Gluza, M. Tendera, T. Niklewski, K. Wilczek, P. Chodor, T. Podolecki, A. Frycz-Kurek, M. Zembala, S. Yurdakul, O. Yildirimturk, Y. Tayyareci, K. Memic, I. C. C. Demiroglu, S. Aytekin, C. J. Garcia Alonso, E. Ferrer Sistach, L. Delgado, J. Lopez Ayerbe, N. Vallejo Camazon, F. Gual Capllonch, M. Espriu Simon, X. Ruyra, A. Caballero Parrilla, A. Bayes Genis, L. Lecuyer, A. Berrebi, E. Florens, M. Noghin, C. Huerre, P. Achouh, R. Zegdi, J. N. Fabiani, B. De Chiara, A. Moreo, F. Musca, F. De Marco, E. Lobiati, O. Belli, F. Mauri, S. Klugmann, A. Caballero, N. Vallejo, A. Gonzalez Guardia, R. Nunez Aragon, C. Bosch, E. Ferrer, M. L. Pedro Botet, F. Gual, M. Cusma-Piccione, C. Zito, G. Oreto, R. Giuffre, M. C. Todaro, C. M. Barbaro, S. Lanteri, C. Longordo, J. Salvia, A. Bensaid, R. Gallet, E. Fougeres, P. Lim, J. Nahum, J. F. Deux, P. Gueret, E. Teiger, J. L. Dubois-Rande, J. L. Monin, F. Behramoglu, Z. Colakoglu, V. Aytekin, C. Demiroglu, L. Gargani, E. Poggianti, R. Bucalo, M. Rizzo, F. Agrusta, P. Landi, R. Sicari, E. Picano, A. Sutandar, B. B. Siswanto, I. Irmalita, G. Harimurti, S. Y. Hayashi, M. M. Nascimento, B. Lindholm, B. Lind, A. Seeberger, M. A. Pachaly, M. C. Riella, A. Bjallmark, L. A. Brodin, L. Poanta, M. Porojan, D. L. Dumitrascu, I. Ikonomidis, S. Tzortzis, J. Lekakis, D. T. Kremastinos, I. Paraskevaidis, I. Andreadou, M. Nikolaou, P. Katsibri, M. Anastasiou-Nana, A. M. Maceira Gonzalez, C. Ripoll, J. Cosin-Sales, B. Igual, J. Salazar, V. Belloch, J. Cosin-Aguilar, D. J. Pennell, M. Masaki, J. N. Pulido, T. Yuasa, S. Gillespie, B. Afessa, D. R. Brown, S. V. Mankad, J. K. Oh, A. L. Gurghean, A. M. Mihailescu, I. Tudor, C. Homentcovschi, M. Muraru, I. V. Bruckner, C. E. Correia, B. Rodrigues, D. Moreira, L. F. Santos, P. Gama, O. Dionisio, C. Cabral, O. Santos, T. Bombardini, S. Gherardi, G. Arpesella, S. Valente, I. Calamai, E. Pasanisi, S. Sansoni, P. Szymanski, P. Dobrowolski, M. Lipczynska, A. Klisiewicz, P. Hoffman, D. Stepowski, B. Kurtz, G. Grezis-Soulie, A. Savoure, F. Anselme, F. Bauer, J. Castillo, N. Herszkowicz, C. Ferreira, A. Goscinska, K. Mizia-Stec, W. Poborski, O. Azevedo, I. Quelhas, J. Guardado, M. Fernandes, C. S. Miranda, P. Gaspar, A. Lourenco, R. Medeiros, J. Almeida, S. L Bennani, V. Algalarrondo, S. Dinanian, J. Guiader, C. Juin, D. Adams, M. S. Slama, J. J. Onaindia, O. Quintana, S. Velasco, E. Astigarraga, A. Cacicedo, J. Gonzalez, I. Rodriguez, M. Sadaba, M. Eneriz, E. Laraudogoitia Zaldumbide, I. Nunez-Gil, M. Luaces, J. Zamorano, J. C. Garcia Rubira, D. Vivas, B. Ibanez, P. Marcos Alberca, C. Fernandez Golfin, J. Alonso, C. Macaya, J. Silva Marques, A. G. Almeida, V. Carvalho, C. Jorge, D. Silva, M. Gato Varela, S. Martins, D. Brito, M. G. Lopes, E. Tripodi, B. Miserrafiti, V. Montemurro, R. Scali, P. Tripodi, A. Winkler, A. Madej, I. Hausmanowa-Petrusewicz, M. Fijalkowski, A. Koprowski, M. Jaguszewski, R. Galaska, M. Taszner, A. Rynkiewicz, R. Citro, F. Rigo, G. Provenza, Q. Ciampi, M. M. Patella, A. D'andrea, O. Vriz, C. Astarita, E. Bossone, F. Heggemann, T. H. Walter, T. H. Kaelsch, T. Sueselbeck, T. H. Papavassiliu, M. Borggrefe, D. Haghi, T. Monk-Hansen, C. Have Dall, S. Bisgaard Christensen, M. Snoer, F. Gustafsson, H. Rasmusen, E. Prescott, G. Finocchiaro, B. Pinamonti, M. Merlo, G. Barbati, A. Di Lenarda, R. Bussani, G. Sinagra, T. Butz, C. N. Lang, A. Meissner, G. Plehn, H. Yeni, C. Langer, H. J. Trappe, X. Gu, X. Y. Gu, Y. H. He, Z. A. Li, J. C. Han, J. Chen, P. Gaudron, M. Niemann, S. Herrmann, K. Hu, B. Bijnens, H. Hillenbrand, M. Beer, G. Ertl, F. Weidemann, A. Mazzone, M. Mariani, I. Foffa, A. Vianello, S. Del Ry, S. Bevilacqua, M. G. Andreassi, M. Glauber, S. Berti, M. Grabowski, M. Postula, A. Dragulescu, G. Van Arsdell, O. Al-Radi, C. Caldarone, L. Mertens, K. J. Lee, R. P. Casula, H. Yadav, A. Cherian, A. D. Hughes, A. Vitarelli, S. D'orazio, B. L. Nguyen, G. Iorio, D. Battaglia, F. Caranci, V. Padella, L. Capotosto, L. Alessandroni, F. Barilla, C. Cardin, S. Hascoet, M. Saudron, G. Caudron, B. Arnaudis, P. Acar, M. M. Sun, X. H. Shu, C. Z. Pan, X. Y. Fang, D. H. Kong, F. Fang, Q. Zhang, Y. S. Chan, J. M. Xie, W. K. Yip, Y. Y. Lam, J. E. Sanderson, C. M. Yu, M. Rosca, K. O' Connor, G. Romano, J. Magne, A. Calin, D. Muraru, L. Pierard, P. Lancellotti, A. Roushdy, I. Elfiky, G. El Shahid, A. Elfiky, M. El Sayed, K. Wierzbowska-Drabik, L. Chrzanowski, A. Kapusta, E. Plonska-Goscinak, M. Krzeminska-Pakula, M. Kurpesa, T. Rechcinski, E. Trzos, J. D. Kasprzak, M. K. Ersboll, N. Valeur, U. M. Mogensen, M. Andersen, C. Hassager, P. Sogaard, L. V. Kober, M. Kloeckner, D. Hayat, C. Dussault, N. Lellouche, N. Elbaz, A. Demopoulos, G. Hatzigeorgiou, E. Leontiades, A. Motsi, G. Karatasakis, G. Athanassopoulos, P. Zycinski, J. Kasprzak, M. C. Vazquez Alvarez, C. Medrano Lopez, M. Camino Lopez, S. Granja, J. L. Zunzunegui Martinez, E. Maroto Alvaro, W.-C. Tsai, J.-Y. Chen, Y.-W. Liu, C.-C. Lin, L.-M. Tsai, D. C. Gomes, S. Robalo Martins, M. R. Gois, S. Ribeiro, A. Nunes Diogo, P. Sengupta, G. Di Bella, G. Caracciolo, S. Lentini, E. Kinova, N. Zlatareva, A. Goudev, N. Papagiannis, M. Mpouki, A. Papagianni, M. Vorria, G. Mpenetos, D. Lytra, E. Papadopoulou, P. Sgourakis, J. Malakos, J. Kyriazis, V. Kodali, R. Toole, A. S. Gopal, J. Celutkiene, A. Rudys, V. Grabauskiene, S. Glaveckaite, E. Sadauskiene, Z. Lileikiene, N. Bickauskaite, E. Ciburiene, V. Skorniakov, A. Laucevicius, C. H. Attenhofer Jost, M. Pfyffer, R. Lindquist, J. L. F. Santos, O. R. C. Coelho, C. M. Mady, M. H. P. Picard, V. M. C. Salemi, L. Funk, M. W. Prull, J.-Y. Shih, Y.-Y. Huang, K. O'connor, M. Moonen, L. A. Pierard, D. C. Cozma, C. Mornos, A. Ionac, L. Petrescu, D. Dragulescu, R. Dan, I. Popescu, S. I. Dragulescu, T. G. Von Lueder, A. Hodt, G. F. Gjerdalen, T. E. Andersen, E. E. Solberg, K. Steine, T. Van Mieghem, M. Rostek, W. Pikto-Pietkiewicz, M. Dluzniewski, A. Antoniewicz, S. Poletajew, A. Borowka, T. Pasierski, S. K. Malyutina, M. Ryabikov, J. Ragino, A. Ryabikov, S. Sitia, L. Tomasoni, F. Atzeni, L. Gianturco, P. Sarzi-Puttini, V. De Gennaro Colonna, M. Turiel, F. R. Gutierrez, G. Lefhtheriotis, R. T. Hurst, M. R. Nelson, F. Mookadam, V. Thota, U. Emani, M. Al Harthi, J. Stepanek, S. Cha, S. J. Lester, E. M. M. Ho, L. Hemeryck, M. Hall, K. Scott, K. Bennett, A. Mahmud, C. Daly, G. King, R. T. Murphy, A. S. Brown, A. J. Teske, J. D'Hooge, P. Claus, F. Rademakers, L. Santos, N. Cortez-Dias, S. Goncalves, M. Almeida Ribeiro, A. Bordalo E Sa, C. Magnino, P. Marcos-Alberca, A. Milan, C. Almeria, V. Caniadas, J. L. Rodrigo, L. Perez De Isla, J. L. Zamorano, U. Gustafsson, M. Larsson, P. Lindqvist, L. Brodin, A. Waldenstrom, B. Roosens, S. Hernot, S. Droogmans, G. Van Camp, T. Lahoutte, B. Cosyns, C. M. Rao, D. Aguglia, G. Casciola, C. Imbesi, A. Marvelli, M. Sgro, D. Benedetto, R. Tripepi, C. Zoccali, F. A. Benedetto, L. P. Badano, M. Cardillo, L. Del Mestre, P. Gianfagna, A. Proclemer, H. D. Tschernich, B. Mora, E. Base, U. Weber, J. Dumfarth, C. Mukherjee, H. S. Skaltsiotis, A. K. Kaladaridis, D. B. Bramos, G. K. Kottis, A. A. Antoniou, I. A. Agrios, D. T. Takos, N. V. Vasiladiotis, K. P. Pamboucas, S. T. T. Toumanidis, A. Shim, P. Lipec, B. Michalski, B. Wozniakowski, L. Stefanczyk, A. Rotkiewicz, M. Cameli, M. Lisi, M. Padeletti, E. Bigio, S. Bernazzali, C. Tsoulpas, M. Maccherini, M. Henein, S. Mondillo, I. Garcia Lunar, S. Mingo Santos, V. Monivas Palomero, C. Mitroi, P. Beltran Correas, L. Ruiz Bautista, A. Muniz Lozano, M. Gonzalez Gonzalez, B. Stegemann, K. Willson, R. Zeppellini, A. Iavernaro, M. Zadro, M. Carasi, R. De Domenico, T. Rigo, E. Artuso, G. Erente, A. Ramondo, T. T. Le, F. Q. Huang, Y. Gu, and R. S. Tan

Subjects
Cardiac function curve, medicine.medical_specialty, medicine.anatomical_structure, business.industry, Ventricle, Internal medicine, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine, Rotation, business
Published
2010

16. Situational Analysis of Young Children in a Changing World

Author

Nirmala Rao, Patrice L. Engle, and O Petrovic

Subjects
Political science, Situation analysis, Developmental psychology
Abstract

Millions of the world’s young children do not develop to their full potential due to factors such as poverty, HIV/AIDS, and armed conflict. This chapter examines child, family, community, and environmental factors affecting the status of the world’s children, and, when data are available, changes in children’s status in recent years. Contextual changes such as urbanization, external migration, socially defined gender roles, and environmental issues that influence the way young children grow and develop are highlighted, and recommendations for policies and programs to improve young children’s well-being are outlined.

Published
2013

17. Phages of Pseudomonas aeruginosa: response to environmental factors and in vitro ability to inhibit bacterial growth and biofilm formation

Author

P, Knezevic, D, Obreht, S, Curcin, M, Petrusic, V, Aleksic, R, Kostanjsek, and O, Petrovic

Subjects
Bacteriolysis, Biofilms, Pseudomonas aeruginosa, Temperature, Animals, Female, Rats, Wistar, Siphoviridae, Podoviridae, Pseudomonas Phages, Rats
Abstract

To examine effects of various environmental factors on adsorption and inactivation of Pseudomonas aeruginosa-specific phages: δ (family Podoviridae), J-1, σ-1 and 001A (family Siphoviridae) and their ability to inhibit bacterial growth and biofilm formation.The phages examined in the study were clonally different, as revealed by RFLP. The temperature in the range 7-44°C had no influence on the adsorption of Podoviridae, but did affect Siphoviridae adsorption, particularly 001A. All phages were significantly stable at pH 5-9, and phages δ and 001A even at pH 3. Most of the examined carbohydrates and exopolysaccharides of the original host efficiently inactivated phage δ, while phages σ-1 and J-1 were inactivated considerably only by the amino acid alanine. Silver nitrate efficiently inactivated all the phages, while Siphoviridae were more resistant to povidone-iodine. Serum of nonimmunized rats had no influence on phage inactivation and adsorption. Only phage δ showed ability to effectively inhibit in vitro bacterial growth and biofilm formation.The examined environmental parameters can significantly influence the adsorption and viability of Ps. aeruginosa-specific phages. The phage δ is a good candidate for biocontrol of Ps. aeruginosa.The study provides important data on Ps. aeruginosa-specific phage adsorption, inactivation and in vitro lytic efficacy.

Published
2011

18. The Biosorption of Selected Pesticides from Water by Biologically Activated Carbon

Author

E. Karlovic, O. Petrovic, D. Miskovic, Zagorka Tamas, and Bozo Dalmacija

Subjects
Environmental Engineering, Chemistry, Biofilm, Biosorption, Quinalphos, Pesticide, chemistry.chemical_compound, Adsorption, Environmental chemistry, medicine, Degradation (geology), Lindane, Water Science and Technology, Activated carbon, medicine.drug
Abstract

The work describes a study of the possibility of removal of organo-phosphorus insecticide quinalphos and organochlorine herbicide lindane from water by using the biofilm formed on active carbon. It was established that two similtaneous processes took place in the biosorption column - adsorption and microbiological degradation of the adsorbed matter. At the shock concentrations of lindane in the influent, an inhibition of microbiological processes in the biofilm occurred. It was observed that the biosorption system was more efficient in the removal of the organo-phosphorus insecticide than of the organo-chlorine herbicide.

Published
1992

19. The Long Term Investigation of the River Danube Water Quality in the Yugoslav Section According to Microbiological Parameters

Author

M. Matavulj, O. Petrovic, S. Gajin, and M. Gantar

Subjects
Hydrology, Environmental Engineering, Activity measurements, Heterotroph, Environmental science, Water quality, Water pollution, River water, Self purification, River danube, Water Science and Technology
Abstract

The results of investigations of Danube river water quality in the Yugoslav section in the period from 1975 to 1988 are presented. The estimation of water quality was based on the numbers of heterotrophs, T/H ratio, and enzymatic activity. In addition, the number of bacteria of some physiological groups was determined. The results indicate that there was a deterioration of water quality in the investigated period. The number of heterotrophs was observably lower in the period from 1975 to 1978 than it has been in recent years. The constant worsening of the water quality is also evident from the the T/H ratio and enzymatic activity measurements.

Published
1990

20. Cyclic variation of integrated backscatter: dependence of time delay on the echocardiographic view used and the myocardial segment analyzed

Author

A E, Finch-Johnston, H M, Gussak, J, Mobley, M R, Holland, O, Petrovic, J E, Pérez, and J G, Miller

Subjects
Adult, Time Factors, Echocardiography, Anisotropy, Humans, Middle Aged
Abstract

To determine the influence of myocardial anisotropy in ultrasonic tissue characterization, we measured the time delay (and magnitude) of the cyclic variation of myocardial integrated backscatter from specific segments visualized in the 4 standard transthoracic echocardiographic views. The cyclic variation data in 10 myocardial regions were obtained from analyses of 2-dimensional integrated backscatter images from 23 healthy subjects. Resultant values (mean +/- SD) for the time delay were as follows: parasternal long-axis view: 1.08 +/- 0.17 (septum) and 1.00 +/- 0.14 (posterior wall); parasternal short-axis view: 1.03 +/- 0.16 (anterior septum), 1.03 +/- 0.14 (posterior wall), 2.22 +/- 0.71 (lateral wall), and 1.65 +/- 0.66 (posterior septum); apical 4-chamber view: 1.08 +/- 0.31 (septum) and 2.20 +/- 0.79 (lateral wall); and apical 2-chamber view: 1.68 +/- 0.62 (inferior wall) and 2.04 +/- 0.72 (anterior wall). Hence, results of this study indicate that myocardial ultrasonic characterization that uses the cyclic variation is influenced by the echocardiographic view and the specific segment of the left ventricle.

Published
2000

21. Antiischemic and hemodynamic effects of an oral single dose of 150 mg of the phosphodiesterase inhibitor enoximone in patients with coronary artery disease--relation to plasma concentration

Author

Hans Armin Dieterich, Hassan Bahavar, J. Neuzner, O. Petrovic, Martin Schlepper, and Veselin Mitrovic

Subjects
Male, medicine.medical_specialty, Cardiac output, Cardiotonic Agents, Phosphodiesterase Inhibitors, Hemodynamics, Administration, Oral, Coronary Disease, Angina, Coronary artery disease, Electrocardiography, medicine.artery, Internal medicine, medicine, Enoximone, Humans, Pharmacology (medical), Aged, Pharmacology, business.industry, Imidazoles, General Medicine, Middle Aged, medicine.disease, Blood pressure, medicine.anatomical_structure, Anesthesia, Pulmonary artery, Vascular resistance, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

The hemodynamic and antiischemic effects of a 150-mg single oral dose of the PDE inhibitor enoximone were correlated with the plasma levels of enoximone and its sulfoxide metabolite. Twenty-one patients with angiographically documented coronary artery disease were investigated by exercise testing 1 and 2 hours after drug administration. The control group consisted of 15 patients with proven coronary artery disease and stable reproducible angina pectoris on exercise. The enoximone group included 14 responders with therapeutic plasma concentrations 2 hours after drug intake and significantly reduced mean pulmonary artery pressures on exercise (from 42.4 +/- 8.6 to 30.9 +/- 11.2 mmHg, p less than 0.05). Compared to basal exercise values, responders showed a reduced ST-segment depression by 1 hour after drug intake (2.1 +/- 1.2 vs. 1.3 +/- 3 mm, p less than 0.05) and minimal values after 2 hours (0.9 +/- 1.0 mm, p less than 0.01) at comparable workloads. There were no significant changes in heart rate, blood pressure, cardiac output, and systemic vascular resistance. No significant improvement in the hemodynamic parameters and ST-segment depression was found in nonresponders with plasma concentrations below 100 ng/ml and 500 mg/ml for enoximone and its metabolite, respectively. In summary, oral administration of enoximone in patients with coronary artery disease led to favorable acute hemodynamic and antiischemic effects at sufficiently high plasma levels of enoximone and its sulfoxide metabolite.

Published
1991

22. Combined Microbiological and Advanced Treatment of Oil Refinery and Municipal Wastewaters

Author

D. Miskovic, O. Petrovic, Z. Zivanov, and Bozo Dalmacija

Subjects
chemistry.chemical_classification, Environmental Engineering, Oil refinery, chemistry.chemical_element, Denitrifying bacteria, chemistry.chemical_compound, Adsorption, Wastewater, chemistry, Nitrate, Environmental chemistry, Organic matter, Carbon, Effluent, Water Science and Technology
Abstract

A study has been done of the primary microbiolooical purification of mixed oil refinery and municipal wastewater using the active sludge process in a two-stage laboratory set-up. The advanced - secondary microbiological treatment of the mixed wastewaters was accomplished by using biologically active carbon. The highest total effect of the organic matter removal for both the primary and secondary microbiological treatment was achieved when the two wastewaters were mixed in the ratio 1:1, and it ranged from 97.7 to 99.2 %, The organic matter load in the effluent expressed as BOD5, was 0.3 - 5.7 mg O2/dm3. When conditions in the columns containing biologically active carbon were changed from aerobic into anaerobic ones, the denitrification bacteria were allowed to use the adsorbed organic matter as the substrate. In this way, the achieved nitrate removal was up to 72 %. It was found that active carbon had adsorbed the organic matter 1.37 - 2.10 times more than was its adsorption capacity, while the free surface degree was in the ranoe of 44.5 - 59.7 %. On the basis of the obtained results, the kinetic coefficients were calculated for both the primary and secondary microbiological treatment of the mixture of the oil refinery and municipal wastewaters. Finally, two alternatives of the technological procedure were proposed for such treatment.

Published
1986

23. Microbiological Aspects of the Treatment of Joint Oil Refinery and Municipal Wastewaters

Author

Bozo Dalmacija, D. Miskovic, M. Gantar, O. Petrovic, and S. Gajin

Subjects
Secondary treatment, Denitrifying bacteria, Environmental Engineering, Denitrification, Activated sludge, Waste management, Wastewater, Chemistry, Aeration, Pulp and paper industry, Refinery, Water Science and Technology, Coliform bacteria
Abstract

The bacteriological parameters of both the primary and secondary microbiological treatment of mixed oil refinery and municipal wastewaters have here been analyzed. Primary treatment was performed using activated sludge in a two grade bioreactor and for the secondary treatment, four columns with granular activated carbon were used. The first and the last column were aerated, whereas the two in the middle were without aeration. The ratios of the oil refinery (R) to municipal (M) wastewaters in the mixtures were 85:15, 70:30, 50:50 and 30:70. The microbiological analyses included the total bacterial count (direct method), the number of heterotrophs and oligotrophs with their ratios, number of coliforms, nitrifying and denitrifying bacteria (growing method). Activated sludge as well as microbial community on the activated carbon were investigated by using scanning electron microscopy. Chemical parameters, such as pH, COD, BOD, NH4+, NO2− and NO3− were determined by the standard methods. The performed microbiological analysis approved the validity of the joint oil refinery and municipal wastewater treatment. The decrease of the organic load in purified water ranged from 88 to 96 % (COD estimate) and from 91 to 99 % (BOD estimate) while the removal of individual groups of microorganisms varied from 55 to 99 %. The highest decrease was observed in the coliform bacteria (97 - 99 %). It is worth noting that a decrease in the total nitrogen in the system ranged from 59 to 74 % and that of nitrate from 56 to 61 % after secondary microbiological treatment.

Published
1986

24. A Multi-Microprocessor Based Distance Relay: Design Requirements and Implementation Characteristics

Author

Mladen Kezunovic, S. Kreso, and O. Petrovic

Subjects
Microprocessor, Engineering, Software, Relay, law, business.industry, Embedded system, Interface (computing), Protective relay, Systems architecture, Electronic engineering, business, law.invention
Abstract

This paper describes a Multi-microprocessor Based Distance Relay implementation. Design requirements are outlined first. Detailed discussion of system, maintenance and testing, interface and cost/performance requirements is given. Second part of the paper provides an overview of the implementation characteristics. System architecture, hardware, software and algorithm issues are presented. Finally, a conclusion is drawn related to the major advantages of the design as well as to the future testing and evaluation procedures.

Published
1985

25. Investigation of Bioregeneration of Activated Carbon in the Combined Advanced Oil Refinery and Municipal Wastewater Treatment

Author

S. Gajin, Z. Zivanov, M. Gantar, O. Petrovic, D. Miskovic, and B. Dalmacija

Subjects
chemistry.chemical_classification, Powdered activated carbon treatment, Denitrifying bacteria, Adsorption, chemistry, Wastewater, Environmental chemistry, Biofilter, medicine, Organic matter, Effluent, Activated carbon, medicine.drug
Abstract

In this paper the adsorption of organic matter on activated carbon from primary microbiologically treated mixtures of oil refinery and municipal wastewaters, as well as its simultaneous desorption by microbiological oxidation is considered. It has been established that the denitrification bacteria use the adsorbed organic matter as a carbon source in the denitrification process. In this way a bioregeneration of the activated carbon has been achieved, as well as the control of organic and nitrate load in the effluent. Changes in the activated carbon adsorption characteristics, free surface degree (FSD) and adsorption degree (AD) were measured in parallel to the organic and nitrate load determination. Also, the microflora on the biologically activated carbon was followed by means of scanning electron microscopy (SEM) and cultivation methods. Kinetics of the microbiological oxidation, as well as of the nitrogen compounds removal was described by a modified mathematical model for biofiltration.

Published
1986

32. Does Atrial Fibrillation at Diagnosis Change Prognosis in Patients with Aortic Stenosis?

Author

Petrovic O, Vidanovic S, Jovanovic I, Paunovic I, Rakocevic I, Milasinovic D, Tesic M, Boskovic N, Dukic D, Ostojic M, Vratonjic J, Mladenovic A, and Trifunovic-Zamaklar D

Abstract

Background: Aortic stenosis (AS) is a common valve disease and atrial fibrillation (AF) is the most common cardiac arrhythmia, frequently associated with AS. This study aimed to evaluate the impact of AF on mortality in patients with moderate and severe AS. Methods: We retrospectively analyzed 1070 consecutive moderate and severe AS patients (57% were male, age was 69 ± 10, severe AS 22.5%), who underwent transthoracic echocardiography from March 2018 to November 2021. AS severity was defined by specific threshold values with severe AS being defined by a peak velocity > 4 m/s, an MPG > 40 mmHg, and an AVA < 1 cm 2 and moderated by a peak velocity of 3-4 m/s, an MPG 20-40 mmHg and an AVA 1-1.5 cm. Patients with AF were defined as those having a history of AF when AS was found on the index echocardiography. The follow-up assessment in December 2023 ascertained vital status and data on aortic valve replacement (AVR). Results: 790 (73.8%) patients were with sinus rhythm (SR) and 280 (26.2%) patients with AF. Mortality was higher in patients with AF than in those with SR (46% vs. 36.2% HR 1.424, 95% CI 1.121-1.809, p = 0.004). After adjusting for clinical confounders, mortality risk in AF relative to SR remained significant (HR 1.284, 95% CI 1.03-1.643, p = 0.047). Patients with AF demonstrated high mortality risk in the moderate aortic stenosis stratum (HR 1.376, 95% CI 1.059-1.788, p = 0.017), with even greater risk in the severe AS stratum (HR 1.644, 95% CI 1.038-2.603, p = 0.034) with significant interaction ( p = 0.007). In patients with AF AVR demonstrated a protective effect on survival (HR 0.365, 95% CI 0.202-0.627, p < 0.001), but to a lesser degree than in patients with sinus rhythm (HR 0.376, 95% CI 0.250-0.561, p < 0.001) without significant interaction ( p = 0.278). In patients with AF mortality risk was high in the conservative treatment stratum (HR 1.361, 95% CI 1.066-1.739, p = 0.014), in the AVR stratum mortality risk was higher but did not reach statistical significance (HR 1.823, 95% CI 0.973-3.414, p = 0.061). However, when corrected for echocardiographic variables strongly correlated with AF, AF was no longer independently associated with all-cause mortality. (HR 0.97 95% CI 0.709-1.323, p = 0.84). Conclusions: Patients with moderate and severe AS and AF have worse prognosis than patients with SR which can be explained by cardiac damage. AVR improves survival in patients with AF and with SR.

Published
2024
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33. Imaging in Infective Endocarditis-Current Opinions and Trends in Cardiac Computed Tomography.

Author

Petkovic A, Menkovic N, Petrovic O, Bilbija I, Nisevic M, Radovanovic NN, Stanisavljevic D, Putnik S, Maksimovic R, and Ivanovic B

Abstract

Infective endocarditis is a rare disease with an increasing incidence and an unaltered high mortality rate, despite medical development. Imaging plays an integrative part in the diagnosis of infective endocarditis, with echocardiography as the initial diagnostic test. Research data in the utility of cardiac computed tomography (CCT) in the diagnostic algorithm of IE are rising, which indicates its importance in detection of IE-related lesion along with the exclusion of coronary artery disease. The latest 2023 European Society of Cardiology Guidelines in the management of IE classified CCT as class of recommendation I and level of evidence B in detection of both valvular and paravalvular lesions in native and prosthetic valve endocarditis. This review article provides a comprehensive and contemporary review of the role of CCT in the diagnosis of IE, the optimization of acquisition protocols, the morphology characteristics of IE-related lesions, the published data of the diagnostic performance of CCT in comparison to echocardiography as the state-of-art method, as well as the limitations and future possibilities.

Published
2024
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34. Correlation of Non-Invasive Transthoracic Doppler Echocardiography with Invasive Doppler Wire-Derived Coronary Flow Reserve and Their Impact on Infarct Size in Patients with ST-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention.

Author

Milasinovic D, Tesic M, Nedeljkovic Arsenovic O, Maksimovic R, Sobic Saranovic D, Jelic D, Zivkovic M, Dedovic V, Juricic S, Mehmedbegovic Z, Petrovic O, Trifunovic Zamaklar D, Djordjevic Dikic A, Giga V, Boskovic N, Klaric M, Zaharijev S, Travica L, Dukic D, Mladenovic D, Asanin M, and Stankovic G

Abstract

Background : Coronary microvascular dysfunction is associated with adverse prognosis after ST-segment elevation myocardial infarction (STEMI). We aimed to compare the invasive, Doppler wire-based coronary flow reserve (CFR) with the non-invasive transthoracic Doppler echocardiography (TTDE)-derived CFR, and their ability to predict infarct size. Methods : We included 36 patients with invasive Doppler wire assessment on days 3-7 after STEMI treated with primary percutaneous coronary intervention (PCI), of which TTDE-derived CFR was measured in 47 vessels (29 patients) within 6 h of the invasive Doppler. Infarct size was assessed by cardiac magnetic resonance at a median of 8 months. Results : The correlation between invasive and non-invasive CFR was modest in the overall cohort (rho 0.400, p = 0.005). It improved when only measurements in the LAD artery were considered (rho 0.554, p = 0.002), with no significant correlation in the RCA artery (rho -0.190, p = 0.435). Both invasive (AUC 0.888) and non-invasive (AUC 0.868) CFR, measured in the recanalized culprit artery, showed a good ability to predict infarct sizes ≥18% of the left ventricular mass, with the optimal cut off values of 1.85 and 1.80, respectively. Conclusions : In patients with STEMI, TTDE- and Doppler wire-derived CFR exhibit significant correlation, when measured in the LAD artery, and both have a similarly strong association with the final infarct size.

Published
2024
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35. Late presentation of traumatic tricuspid valve chordal rupture and pericardial rupture with cardiac herniation: a case report.

Author

Radovanovic N, Prodanovic M, Radosavljevic-Radovanovic M, Bilbija I, Petrovic O, Lojovic N, Kecman E, Djekic A, Radovanovic M, and Matic D

Subjects
Male, Humans, Middle Aged, Tricuspid Valve diagnostic imaging, Tricuspid Valve surgery, Echocardiography adverse effects, Pericardium diagnostic imaging, Pericardium surgery, Rupture complications, Wounds, Nonpenetrating complications, Wounds, Nonpenetrating diagnostic imaging, Wounds, Nonpenetrating surgery, Tricuspid Valve Insufficiency diagnostic imaging, Tricuspid Valve Insufficiency etiology, Tricuspid Valve Insufficiency surgery, Thoracic Injuries diagnosis, Heart Injuries complications, Heart Injuries diagnostic imaging
Abstract

Background: Although chest trauma happens very often, accompanying tricuspid valve injuries occur rarely and may be manifested by scarce symptoms and signs. Pericardial rupture with cardiac herniation is even a bigger rarity. Transthoracic echocardiography plays a key role in the diagnosis of valve injuries but is of limited value in cardiac herniation., Case Presentation: We present the case of 58-year-old man who experienced severe chest trauma in a car accident. Symptoms of right heart failure occurred 10 years after the injury, due to the loss of tricuspid leaflet support caused by the rupture of tendinous chords with significant tricuspid regurgitation. Intraoperatively, old posttraumatic pericardial rupture into left pleura was also found, with partial cardiac herniation and pressure of the edge of pericardium on all left-sided coronary arteries simultaneously. The patient was successfully operated and is free of symptoms 4 years later., Conclusions: This case emphasizes the importance of timely diagnosis and underlines a mechanism that leads to delayed rupture of the tricuspid valve apparatus. Repeated echocardiography in all patients who experienced chest trauma could be of great importance. Also, given the limited value of echocardiography in posttraumatic pericardial rupture and cardiac herniation, cardiac computed tomography should be performed., (© 2024. The Author(s).)

Published
2024
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36. The Role of Echocardiography and Cardiac Computed Tomography in Diagnosis of Infective Endocarditis.

Author

Petkovic A, Menkovic N, Petrovic O, Bilbija I, Radovanovic NN, Stanisavljevic D, Putnik S, Maksimovic R, and Ivanovic B

Abstract

Background: Infective endocarditis (IE) is a rare disease with a high mortality rate and rising incidence, requiring timely and precise diagnosis in order to choose appropriate therapy. Imaging of morphologic lesions is an integrative part of diagnosis. Artifacts and the patient's habitus make echocardiography difficult to visualize advanced-form IE. Cardiac computed tomography (CCT) constantly shows an additive diagnostic value due to high resolution of cardiac anatomy. Conjecturally, joint application of both diagnostic tests improves overall sensitivity and specificity in diagnosing IE., Methods: Patients with definite IE underwent transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), and CCT. We analyzed valvular and paravalvular IE lesions in all three imaging methods and compared them to surgical or autopsy findings. We calculated sensitivity, specificity, diagnostic accuracy, and positive and negative predictive value of both imaging tests individually and jointly used., Results: We examined 78 patients, male to female ratio 2:1, mean age 52.29 ± 16.62. We analyzed 85 valves, 70 native valves, 13 prosthetic valves, and 2 corrected valves due to Ozaki procedure, along with a central shunt and 4 pacemaker leads. As a single test, the sensitivity and specificity of CCT, TTE, and TEE for valvular lesions were 91.6/20%, 65.5/57.9%, and 60/84%, and paravalvular lesions were 100/0%, 46/10.5%, and 14.7/100%. When combined together, sensitivity and specificity for valvular lesions rose to 96.6/0% and paravalvular lesions to 100/0%. We also analyzed the diagnostic performance for each test in single and mutual application, per specific IE lesion., Conclusion: In the individual application, CCT in comparison to TTE and TEE shows better diagnostic performance in detection of valvular and paravalvular lesions. In joint application, there is a statistically significant difference in performance compared to their single use, especially in prosthetic valves and invasive forms of IE native valves.

Published
2023
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37. The Potential of Liquid Biopsy in Detection of Endometrial Cancer Biomarkers: A Pilot Study.

Author

Kodada D, Hyblova M, Krumpolec P, Janostiakova N, Barath P, Grendar M, Blandova G, Petrovic O, Janega P, Repiska V, and Minarik G

Subjects
Humans, Female, Biomarkers, Tumor genetics, Pilot Projects, Reproducibility of Results, Mutation, Liquid Biopsy methods, Circulating Tumor DNA genetics, Endometrial Neoplasms diagnosis, Endometrial Neoplasms genetics
Abstract

Endometrial cancer belongs to the most common gynecologic cancer types globally, with increasing incidence. There are numerous ways of classifying different cases. The most recent decade has brought advances in molecular classification, which show more accurate prognostic factors and the possibility of personalised adjuvant treatment. In addition, diagnostic approaches lag behind these advances, with methods causing patients discomfort while lacking the reproducibility of tissue sampling for biopsy. Minimally invasive liquid biopsies could therefore represent an alternative screening and diagnostic approach in patients with endometrial cancer. The method could potentially detect molecular changes in this cancer type and identify patients at early stages. In this pilot study, we tested such a detection method based on circulating tumour DNA isolated from the peripheral blood plasma of 21 Slovak endometrial cancer patients. We successfully detected oncomutations in the circulating DNA of every single patient, although the prognostic value of the detected mutations failed to offer certainty. Furthermore, we detected changes associated with clonal hematopoiesis, including DNMT3A mutations, which were present in the majority of circulating tumour DNA samples.

Published
2023
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38. The role of imaging in infective endocarditis.

Author

Ivanovic B, Popovic J, Dukic D, Petkovic A, and Petrovic O

Subjects
Echocardiography methods, Humans, Echocardiography, Transesophageal methods, Endocarditis diagnostic imaging
Abstract

Infective endocarditis (IE) poses a large diagnostic and therapeutical challenge. An early diagnosis is necessary for a positive outcome. Echocardiography is initial diagnostic method when there is a possibility of IE presence. TTE and TEE are useful in detection, accurate localisation and estimation of vegetation size, and also in detection of paravalvular spreading of infection. In certain situations, there is a need for usage of complementary methods like CCT and nuclear techniques. This article will outline advantages and limitations of certain diagnostic methods in diagnosis of IE., (© 2022 Wiley Periodicals LLC.)

Published
2022
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39. Role of different echocardiographic modalities in the assessment of microvascular function in women with ischemia and no obstructive coronary arteries.

Author

Jovanovic I, Tesic M, Djordjevic-Dikic A, Giga V, Beleslin B, Aleksandric S, Boskovic N, Petrovic O, Marjanovic M, Vratonjic J, Paunovic I, Ivanovic B, and Trifunovic-Zamaklar D

Subjects
Echocardiography, Female, Humans, Ischemia, Systole, Coronary Vessels diagnostic imaging, Ventricular Dysfunction, Left
Abstract

This review summarizes current knowledge about echocardiographic modalities used to assess microvascular function and left ventricular (LV) systolic function in women with ischemia and no obstructive coronary arteries (INOCA). Although the entire pathophysiological background of this clinical entity still remains elusive, it is primarily linked to microvascular dysfunction which can be assessed by coronary flow velocity reserve. Subtle impairments of LV systolic function in women with INOCA are difficult to assess by interpretation of wall motion abnormalities. LV longitudinal function impairment is considered to be an early marker of subclinical systolic dysfunction and can be assessed by global longitudinal strain quantification., (© 2022 Wiley Periodicals LLC.)

Published
2022
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40. Multimodality imaging for the management of patients with primary mitral regurgitation.

Author

Vratonjic J, Jovanovic I, Petrovic O, Paunovic I, Boricic-Kostic M, Tesic M, Nedeljkovic-Arsenovic O, Maksimovic R, Ivanovic B, and Trifunovic-Zamaklar D

Subjects
Echocardiography methods, Humans, Mitral Valve diagnostic imaging, Multimodal Imaging, Echocardiography, Three-Dimensional methods, Mitral Valve Insufficiency
Abstract

Advanced cardiac imaging (ACI), including myocardial deformation imaging, 3D echocardiography and cardiac magnetic resonance, overcomes the limitations of conventional echocardiography in the assessment of patients with primary mitral regurgitation (MR). They enable a more precise MR quantification and reveal early changes before advanced and irreversible remodeling with depressed heart function occurs. ACI permits a thorough analysis of mitral valvular anatomy and MR mechanisms (important for planning and guiding percutaneous and surgical procedures) and helps to identify structural and functional changes coupled with a high arrhythmogenic potential, especially the occurrence of atrial fibrillation and heart failure development. The key question is how the data provided by ACI can improve the current management of primary MR., (© 2022 Wiley Periodicals LLC.)

Published
2022
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41. Prognostic Value of Transthoracic Doppler Echocardiography Coronary Flow Velocity Reserve in Patients With Asymmetric Hypertrophic Cardiomyopathy.

Author

Tesic M, Beleslin B, Giga V, Jovanovic I, Marinkovic J, Trifunovic D, Petrovic O, Dobric M, Aleksandric S, Juricic S, Boskovic N, Tomasevic M, Ristic A, Orlic D, Stojkovic S, Vukcevic V, Stankovic G, Ostojic M, and Djordjevic Dikic A

Subjects
Adult, Blood Flow Velocity, Female, Humans, Male, Middle Aged, Prognosis, Cardiomyopathy, Hypertrophic diagnostic imaging, Cardiomyopathy, Hypertrophic physiopathology, Echocardiography, Doppler
Abstract

Background Microvascular dysfunction might be a major determinant of clinical deterioration and outcome in patients with hypertrophic cardiomyopathy (HCM). However, long-term prognostic value of transthoracic Doppler echocardiography (TDE) coronary flow velocity reserve (CFVR) on clinical outcome is uncertain in HCM patients. Therefore, the aim of our study was to assess long-term prognostic value of CFVR on clinical outcome in HCM population. Methods and Results We prospectively included 150 HCM patients (82 women; mean age 48±15 years). Patients' clinical characteristics, echocardiographic and CFVR findings (both for left anterior descending [LAD] and posterior descending artery [PD]), were assessed in all patients. The primary outcome was a composite of: HCM related death, heart failure requiring hospitalization, sustained ventricular tachycardia and ischemic stroke. Patients were stratified into 2 subgroups depending on CFVR LAD value: Group 1 (CFVR LAD>2, [n=87]) and Group 2 (CFVR LAD≤2, [n=63]). During a median follow-up of 88 months, 41/150 (27.3%) patients had adverse cardiac events. In Group 1, there were 8/87 (9.2%), whereas in Group 2 there were 33/63 (52.4%, P <0.001 vs. Group 1) adverse cardiac events. By Kaplan-Meier analysis, patients with preserved CFVR LAD had significantly higher cumulative event-free survival rate compared to patients with impaired CFVR LAD (96.4% and 90.9% versus 66.9% and 40.0%, at 5 and 8 years, respectively: log-rank 37.2, P <0.001). Multivariable analysis identified only CFVR LAD≤2 as an independent predictor for adverse cardiac outcome (HR 6.54; 95% CI 2.83-16.30, P <0.001), while CFVR PD was not significantly associated with outcome. Conclusions In patients with HCM, impaired CFVR LAD (≤2) is a strong, independent predictor of adverse cardiac outcome. When the aim of testing is HCM risk stratification and CFVR LAD data are available, the evaluation of CFVR PD is redundant.

Published
2021
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42. The prognostic importance of right ventricular remodeling and the circadian blood pressure pattern on the long-term cardiovascular outcome.

Author

Tadic M, Cuspidi C, Celic V, Petrovic O, Pencic B, Mancia G, Grassi G, and Ivanovic B

Subjects
Adult, Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Blood Pressure physiology, Cardiovascular Diseases diagnosis, Cardiovascular Diseases epidemiology, Cardiovascular Diseases mortality, Cardiovascular Diseases physiopathology, Circadian Rhythm physiology, Hypertension diagnosis, Hypertension epidemiology, Hypertension physiopathology, Ventricular Remodeling physiology
Abstract

Objective: We sought to investigate the predictive value of right ventricular (RV) remodeling and 24-h blood pressure (BP) patterns on long-term cardiovascular prognosis in the initially untreated hypertensive patients., Methods: The current study included 505 initially untreated hypertensive patients who were consequently included in this study from 2007 to 2012. All the patients underwent laboratory analysis, 24-h BP monitoring and echocardiographic examination at baseline. The patients were followed for a median period of 9 years. The adverse outcome was defined as the hospitalization due to cardiovascular events (atrial fibrillation, myocardial infarction, myocardial revascularization, heart failure, stroke, or cardiovascular death)., Results: During the 9-year follow-up period adverse cardiovascular events occurred in 82 hypertensive patients. Night-time SBP, the nondipping BP pattern, left ventricle hypertrophy, RV hypertrophy, right atrial enlargement, RV diastolic dysfunction, and RV systolic dysfunction were associated with adverse cardiovascular events. Nevertheless, night-time SBP, the nondipping BP pattern, mitral E/e', left ventricle hypertrophy, and RV hypertrophy were the only independent predictors of cardiovascular events. When all four BP patterns were included in the model, only the reverse dipping BP pattern was an independent predictor of cardiovascular events., Conclusion: The present investigation showed that RV hypertrophy and the reverse dipping BP pattern were independent long-term predictors of the cardiovascular outcome. Detailed echocardiographic evaluation and 24-h ambulatory blood pressure monitoring should be performed even in low-risk hypertensive patients.

Published
2020
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43. Prompt and consistent improvement of coronary flow velocity reserve following successful recanalization of the coronary chronic total occlusion in patients with viable myocardium.

Author

Dobric M, Beleslin B, Tesic M, Djordjevic Dikic A, Stojkovic S, Giga V, Tomasevic M, Jovanovic I, Petrovic O, Rakocevic J, Boskovic N, Sobic Saranovic D, Stankovic G, Vukcevic V, Orlic D, Simic D, Nedeljkovic MA, Aleksandric S, Juricic S, and Ostojic M

Subjects
Chronic Disease, Coronary Occlusion diagnosis, Coronary Occlusion physiopathology, Coronary Vessels diagnostic imaging, Coronary Vessels surgery, Echocardiography, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Time Factors, Coronary Occlusion surgery, Coronary Vessels physiopathology, Fractional Flow Reserve, Myocardial physiology, Myocardial Contraction physiology, Percutaneous Coronary Intervention
Abstract

Background: Coronary chronic total occlusion (CTO) is characterized by the presence of collateral blood vessels which can provide additional blood supply to CTO-artery dependent myocardium. Successful CTO recanalization is followed by significant decrease in collateral donor artery blood flow and collateral derecruitment, but data on coronary hemodynamic changes in relation to myocardial function are limited. We assessed changes in coronary flow velocity reserve (CFVR) by echocardiography in collateral donor and recanalized artery following successful opening of coronary CTO., Methods: Our study enrolled 31 patients (60 ± 9 years; 22 male) with CTO and viable myocardium by SPECT scheduled for percutaneous coronary intervention (PCI). Non-invasive CFVR was measured in collateral donor artery before PCI, 24 h and 6 months post-PCI, and 24 h and 6 months in recanalized artery following successful PCI of CTO., Results: Collateral donor artery showed significant increase in CFVR 24 h after CTO recanalization compared to pre-PCI values (2.30 ± 0.49 vs. 2.71 ± 0.45, p = 0.005), which remained unchanged after 6-months (2.68 ± 0.24). Baseline blood flow velocity of the collateral donor artery significantly decreased 24 h post-PCI compared to pre-PCI (0.28 ± 0.06 vs. 0.24 ± 0.04 m/s), and remained similar after 6 months, with no significant difference in maximum hyperemic blood flow velocity pre-PCI, 24 h and 6 months post-PCI. CFVR of the recanalized coronary artery 24 h post-PCI was 2.55 ± 0.35, and remained similar 6 months later (2.62 ± 0.26, p = NS)., Conclusions: In patients with viable myocardium, prompt and significant CFVR increase in both recanalized and collateral donor artery, was observed within 24 h after successful recanalization of CTO artery, which maintained constant during the 6 months., Trial Registration: ClinicalTrials.gov (Number NCT04060615 ).

Published
2020
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44. Predictors of unfavourable outcome in aneurysmal subarachnoid haemorrhage.

Author

Nastasovic T, Milakovic B, Stosic M, Eric Marinkovic J, Ilic R, Milicevic M, Cvrkota I, Radinovic K, Petrovic O, and Grujicic D

Subjects
Adult, Female, Humans, Male, Middle Aged, Prospective Studies, Hypertension, Intracranial Aneurysm, Subarachnoid Hemorrhage
Abstract

Background: Mortality rates following aneurysmal subarachnoid haemorrhage (aSAH) have decreased due to improvements in diagnoses and the management of complications, as well as early obliteration of the aneurysms. Neurogenic pulmonary oedema (NPO) is a clinical syndrome associated with an acute increase in intracranial pressure and a release of catecholamines into the circulation. This study investigated independent predictors of unfavourable outcomes (Glasgow Outcome Scores 1, 2 or 3) in patients with aSAH., Materials and Methods: A total of 262 patients with aSAH (162 females) were included in this prospective study. Clinical characteristics were assessed, and electrocardiographic, serum cardiac and inflammatory biomarker measurements were recorded on admission. Outcomes were assessed three months after admission. Univariate and multivariate analyses of these data were used to predict unfavourable outcomes., Results: A total of 156 patients (59.54%) had unfavourable outcomes. Compared to those who had favourable outcomes, patients with unfavourable outcomes were significantly older (54.37 ± 10.56 vs. 49.13 ± 10.77 years; p < 0.001) and had more severe aSAHs (Hunt and Hess grades ≥ 3: 82.7% vs. 39.6%; p < 0.001). Patients with unfavourable outcomes were more likely to have NPO (10.3% vs. 2.8%; p = 0.023), hydrocephalus (34.0% vs. 20.8%; p = 0.02), and aneurysm reruptures (28.2% vs. 3.8%; p < 0.001). Independent predictors of an unfavourable outcome included Hunt and Hess grades ≥ 3 (odds ratio [OR], 4.291; 95% confidence interval [CI], 2.168-8.491; p < 0.001), increased systolic blood pressure on admission (OR, 1.020; 95% CI, 1.002-1.038; p = 0.03), increased heart rate (HR) on admission (OR, 1.024; 95% CI, 1.001-1.048; p = 0.04), and aneurysm rerupture (OR, 4.961; 95% CI, 1.461-16.845; p = 0.01)., Conclusions: These findings suggest that aneurysm reruptures, as well as increased blood pressure and HR, are associated with unfavourable outcomes in patients with aSAH.

Published
2019
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45. The relationship between causative microorganisms and cardiac lesions caused by infective endocarditis: New perspectives from the contemporary cohort of patients.

Author

Trifunovic D, Vujisic-Tesic B, Obrenovic-Kircanski B, Ivanovic B, Kalimanovska-Ostric D, Petrovic M, Boricic-Kostic M, Matic S, Stevanovic G, Marinkovic J, Petrovic O, Draganic G, Tomic-Dragovic M, Putnik S, Markovic D, Tutus V, Jovanovic I, Markovic M, Petrovic IM, Petrovic JM, and Stepanovic J

Subjects
Adult, Aged, Cohort Studies, Echocardiography, Female, Humans, Male, Middle Aged, Staphylococcal Infections microbiology, Staphylococcus aureus, Abscess microbiology, Aneurysm, False microbiology, Endocarditis microbiology, Heart Aneurysm microbiology, Pericardium microbiology
Abstract

Background: The etiology of infective endocarditis (IE) is changing. More aggressive forms with multiple IE cardiac lesions have become more frequent. This study sought to explore the relationship between contemporary causative microorganisms and IE cardiac lesions and to analyze the impact of multiple lesions on treatment choice., Methods: In 246 patients hospitalized for IE between 2008 and 2015, cardiac lesions caused by IE were analyzed by echocardiography, classified according to the 2015 European Society of Cardiology guidelines and correlated with microbiological data. We defined a new parameter, the Echo IE Sum, to summarize all IE cardiac lesions in a single patient, enabling comprehensive comparisons between different etiologies and treatment strategies., Results: Staphylococcus aureus was associated with the development of large vegetation (OR 2.442; 95% CI 1.220-4.889; p=0.012), non-HACEK bacteria with large vegetation (OR 13.662; 95% CI 2.801-66.639; p=0.001), perivalvular abscess or perivalvular pseudoaneurysm (OR 5.283; 95% CI 1.069-26.096; p=0.041), and coagulase-negative staphylococci (CoNS) with leaflet abscess or aneurysm (OR 3.451; 95% CI 1.285-9.266, p=0.014), and perivalvular abscess or perivalvular pseudoaneurysm (OR 4.290; 95% CI 1.583-11.627; p=0.004). The Echo IE Sum significantly differed between different etiologies (p<0.001), with the highest value in non-HACEK and the lowest in streptococcal endocarditis. Patients operated for IE had a significantly higher Echo IE Sum vs those who were medically treated (p<0.001)., Conclusion: None of the IE cardiac lesions is microorganism-specific. However, more severe lesions were caused by S. aureus, CoNS, and non-HACEK bacteria. The highest propensity to develop multiple lesions was shown by the non-HACEK group. Higher Echo IE Sum in patients sent to surgery emphasized the importance of multiple IE cardiac lesions on treatment choice and potential usage of Echo IE Sum in patient management., (Copyright © 2017 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.)

Published
2018
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46. N-terminal pro-brain natriuretic peptide is related with coronary flow velocity reserve and diastolic dysfunction in patients with asymmetric hypertrophic cardiomyopathy.

Author

Tesic M, Seferovic J, Trifunovic D, Djordjevic-Dikic A, Giga V, Jovanovic I, Petrovic O, Marinkovic J, Stankovic S, Stepanovic J, Ristic A, Petrovic M, Mujovic N, Vujisic-Tesic B, Beleslin B, Vukcevic V, Stankovic G, and Seferovic P

Subjects
Adult, Aged, Cardiomyopathy, Hypertrophic diagnostic imaging, Cardiomyopathy, Hypertrophic physiopathology, Coronary Circulation, Diastole, Echocardiography, Doppler, Female, Humans, Male, Middle Aged, Mitral Valve Insufficiency, Multivariate Analysis, Myocardial Ischemia diagnostic imaging, Myocardial Ischemia physiopathology, Ventricular Function, Left, Cardiomyopathy, Hypertrophic blood, Myocardial Ischemia blood, Natriuretic Peptide, Brain blood, Peptide Fragments blood
Abstract

Background: The relations of elevated N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and cardiac ischemia in hypertrophic cardiomyopathy (HCM) patients is uncertain. Therefore we designed the study with the following aims: (1) to analyze plasma concentrations of NT-pro-BNP in various subsets of HCM patients; (2) to reveal the correlations of NT-pro-BNP, myocardial ischemia, and diastolic dysfunction; (3) to assess predictors of the elevated plasma levels of NT-pro-BNP., Methods and Results: In 61 patients (mean age 48.9±16.3 years; 26 male) with asymmetric HCM plasma levels of NT-pro-BNP were obtained. Standard transthoracic examination, tissue Doppler echocardiography with measurement of transthoracic coronary flow velocity reserve (CFVR) in left anterior descending artery (LAD) was done. Mean natural logarithm value of NT-pro-BNP was 7.11±0.95pg/ml [median value 1133 (interquartile range 561-2442)pg/ml]. NT-pro-BNP was significantly higher in patients with higher NYHA class, in obstructive HCM, more severe mitral regurgitation, increased left atrial volume index (LAVI), presence of calcified mitral annulus, elevated left ventricular (LV) filling pressure and in decreased CFVR. Levels of NT-pro-BNP significantly correlated with the ratio of E/e' (r=0.534, p<0.001), LV outflow tract gradient (r=0.503, p=0.024), LAVI (r=0.443, p<0.001), while inversely correlated with CFVR LAD (r=-0.569, p<0.001). When multivariate analysis was done only CFVR LAD and E/e' emerged as independent predictors of NT-pro-BNP., Conclusion: Plasma levels of NT-pro-BNP were significantly higher in HCM patients with more advanced disease. Elevated NT-pro-BNP not only reflects the diastolic impairment of the LV, but it might also be the result of cardiac ischemia in patients with HCM., (Copyright © 2017 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.)

Published
2017
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47. Gauging the response to cardiac resynchronization therapy: The important interplay between predictor variables and definition of a favorable outcome.

Author

Petrovic M, Petrovic M, Milasinovic G, Vujisic Tesic B, Trifunovic D, Petrovic O, Nedeljkovic I, Petrovic I, Banovic M, Boricic-Kostic M, Petrovic J, Arena R, and Popovic D

Subjects
Arterial Pressure physiology, Echocardiography, Doppler methods, Female, Follow-Up Studies, Heart physiopathology, Heart Failure diagnostic imaging, Heart Failure physiopathology, Heart Ventricles diagnostic imaging, Heart Ventricles physiopathology, Humans, Male, Middle Aged, Mitral Valve Insufficiency physiopathology, Predictive Value of Tests, Prospective Studies, Pulmonary Artery physiopathology, Treatment Outcome, Ventricular Dysfunction physiopathology, Cardiac Resynchronization Therapy methods, Echocardiography methods, Heart Failure therapy, Mitral Valve Insufficiency diagnostic imaging, Pulmonary Artery diagnostic imaging, Ventricular Dysfunction diagnostic imaging
Abstract

Aims: Selection of patients who are viable candidates for cardiac resynchronization therapy (CRT), prediction of the response to CRT as well as an optimal definition of a favorable response, all require further exploration. The purpose of this study was to evaluate the interplay between the prediction of the response to CRT and the definition of a favorable outcome., Methods: Seventy patients who received CRT were included. All patients met current guideline criteria for CRT. Forty-three echocardiographic parameters were evaluated before CRT and at 1, 3, 6, and 12 months. M-mode, 2D echocardiography, and Doppler imaging were used to quantify left ventricular (LV) systolic and diastolic function, mitral regurgitation, right ventricular systolic function, pulmonary artery pressure, and myocardial mechanical dyssynchrony. The following definitions of a favorable CRT response were used: left ventricular ejection fraction (LVEF) improvement more >5% acutely following CRT, LVEF improvement >20% at 12-month follow-up, and a LV end-systolic volume (LVESV) decrease >15% at 12-month follow-up., Results: For the LVEF improvement >5%, the best predictor was isovolumetric relaxation time (IVRT; P=.035). For improvement of LVEF >20%, the best predictors were left ventricular stroke index (LVSI; P=.044) and left ventricular fractional shortening (LVFS; P=.031). For the drop in left ventricular systolic volume (LVESV >15%), the best predictor was septal-to-lateral wall delay (ΔT) (P=.043, RR=1.023, 95% CI for RR=1.001-1.045)., Conclusion: The definition of a favorable CRT response influenced the optimal predictor variable(s). Standardization of defining a favorable response to CRT is needed to guide clinical decision making processes., (© 2017, Wiley Periodicals, Inc.)

Published
2017
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48. Positive parenting attitudes and practices in three transitional Eastern European countries: Bosnia and Herzegovina, Macedonia and Serbia.

Author

Petrovic M, Vasic V, Petrovic O, and Santric-Milicevic M

Subjects
Adolescent, Child, Child, Preschool, Cross-Sectional Studies, Europe, Eastern, Female, Humans, Logistic Models, Male, Serbia, Surveys and Questionnaires, Health Knowledge, Attitudes, Practice, Parenting, Parents psychology
Abstract

Objectives: To identify potential predictors of using only non-violent forms of discipline for children aged 2-14 years and of being against physical punishment among Roma and non-Roma parents/caregivers in Eastern European countries with similar cultural-historical backgrounds., Methods: UNICEF Multiple Indicator Cluster Survey data collected in 2010-2011 in Bosnia and Herzegovina, Macedonia and Serbia (total of 9973 respondents) were analysed using multivariate logistic regression modelling with receiver operating characteristic analysis., Results: Approximately 27 % of the respondents practiced only non-violent child discipline. Roma children experienced only non-violent discipline less than half as often as their non-Roma counterparts. Household wealth index and child sex were significant predictors of positive parenting attitudes and practice. For Roma respondents, rural residence also contributed to being against physical punishment., Conclusions: Parents\caregivers from more affluent households are more likely than those who are less affluent to be against physical punishment of children and are more likely to practice only non-violent discipline. Evidence-based interventions are required to support existing positive forms of child rearing. These should target less affluent households from Roma settlements in the studied countries.

Published
2016
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49. Co-expression of vascular and lymphatic endothelial cell markers on early endothelial cells present in aspirated coronary thrombi from patients with ST-elevation myocardial infarction.

Author

Rakocevic J, Kojic S, Orlic D, Stankovic G, Ostojic M, Petrovic O, Zaletel I, Puskas N, Todorovic V, and Labudovic-Borovic M

Subjects
Biomarkers analysis, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors blood, Myocardial Infarction pathology, Neovascularization, Pathologic metabolism, Thrombosis metabolism, Antigens, CD34 metabolism, Endothelial Cells metabolism, Myocardial Infarction metabolism, Platelet Endothelial Cell Adhesion Molecule-1 metabolism, Vascular Endothelial Growth Factor Receptor-3 metabolism, Vesicular Transport Proteins metabolism
Abstract

Introduction: Angiogenesis is the growth of both new vascular and lymphatic blood vessels from the existing vasculature. During this process, blood endothelial cells (BECs) and lymphatic endothelial cells (LECs) express specific markers, which help their discrimination and easier identification. Since the coronary thrombi material aspirated from patients with ST-elevation myocardial infarction (STEMI) proved as good angiogenesis model, we investigated the expression of CD34 and CD31 as BECs markers, and D2-40, LYVE-1 and VEGFR3 as LEC markers in this material., Materials and Methods: Aspirated thrombi were stained immunohistochemically for CD34, CD31, D2-40, LYVE-1 and VEGFR3. Organizational patterns of immunopositive cells were graded as single cells, clusters or microvessels. Double immunofluorescence for CD31, D2-40, LYVE-1 and VEGRF3 was done. Thrombi were also graded as fresh (<1day old), lytic (1-5days old) and organized (>5days old)., Results: Serial sections of aspirated thrombi showed concordant BEC and LEC markers immunopositivity. Double immunoflorescence proved co-expression of CD31 and LEC markers on the same cells. Cells expressing LEC markers organized in clusters and microvessels were mainly present in lytic and organized thrombi., Conclusion: Co-expression of BEC and LEC markers on the same non-tumorous cell during thrombus neovascularization indicates existing in vivo plasticity of endothelial cells under non-tumorous pathological conditions. It also points that CD34 and CD31 on one hand, and D2-40, LYVE-1 and VEGFR3 immunostaining on the other hand, cannot solely be a reliable indicators whether vessel is lymphatic or not., (Copyright © 2015 Elsevier Inc. All rights reserved.)

Published
2016
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50. Coronary flow of the infarct artery assessed by transthoracic Doppler after primary percutaneous coronary intervention predicts final infarct size.

Author

Trifunovic D, Sobic-Saranovic D, Beleslin B, Stankovic S, Marinkovic J, Orlic D, Vujisic-Tesic B, Petrovic M, Nedeljkovic I, Banovic M, Djukanovic N, Petrovic O, Petrovic M, Stepanovic J, Djordjevic-Dikic A, Tesic M, and Ostojic M

Subjects
Adenosine, Aged, Biomarkers blood, Blood Flow Velocity, Coronary Vessels physiopathology, Creatine Kinase, MB Form blood, Feasibility Studies, Female, Humans, Male, Microcirculation, Middle Aged, Multivariate Analysis, Myocardial Infarction blood, Myocardial Infarction diagnostic imaging, Myocardial Infarction physiopathology, Myocardial Perfusion Imaging methods, Predictive Value of Tests, Prospective Studies, Serbia, Time Factors, Tomography, Emission-Computed, Single-Photon, Treatment Outcome, Vasodilator Agents, Coronary Vessels diagnostic imaging, Echocardiography, Doppler, Fractional Flow Reserve, Myocardial, Myocardial Infarction therapy, Percutaneous Coronary Intervention
Abstract

Coronary microcirculatory function after primary percutaneous coronary intervention (pPCI) in patients with acute myocardial infarction is important determinant of infarct size (IS). Our aim was to investigate the utility of coronary flow reserve (CFR) and diastolic deceleration time (DDT) of the infarct artery (IRA) assessed by transthoracic Doppler echocardiography after pPCI for final IS prediction. In 59 patients, on the 2nd day after pPCI for acute anterior myocardial infarction, transthoracic Doppler analysis of IRA blood flow was done including measurements of CFR, baseline DDT and DDT during adenosine infusion (DDT adeno). Killip class, myocardial blush grade, resolution of ST segment elevation, peak creatine kinase-myocardial band and conventional echocardiographic parameters were determined. Single-photon emission computed tomography myocardial perfusion imaging was done 6 weeks later to define final IS (percentage of myocardium with fixed perfusion abnormality). IS significantly correlated with CFR (r = -0.686, p < 0.01), DDT (r = -0.727, p < 0.01), and DDT adeno (r = -0.780, p < 0.01). CFR and DDT adeno in multivariate analysis remained independent IS predictors after adjustment for other covariates and offered incremental prognostic value in models based on conventional clinical, angiographic, electrocardiographic and enzymatic variables. In predicting large infarction (IS > 20 %), the best cut-off for CFR was <1.73 (sensitivity 65 %, specificity 96 %) and for DDT adeno ≤720 ms (sensitivity 81 %, specificity 96 %). CFR and DDT during adenosine are independent and powerful early predictors of final IS offering incremental prognostic information over conventional parameters of myocardial and microvascular damage and tissue reperfusion.

Published
2014
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