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3. Paradoxical reaction to epinephrine induced by beta-blockers in an anaphylactic shock induced by penicillin.

Author

Goddet NS, Descatha A, Liberge O, Dolveck F, Boutet J, Baer M, Fletcher D, and Templier F

Subjects
Adrenergic beta-Agonists therapeutic use, Drug Administration Schedule, Drug Antagonism, Drug Synergism, Emergency Medical Services methods, Emergency Treatment adverse effects, Emergency Treatment methods, Epinephrine therapeutic use, Female, Humans, Hypertension drug therapy, Medical History Taking, Medication Errors adverse effects, Middle Aged, Practice Guidelines as Topic, Risk Factors, Self Administration adverse effects, Vasoconstrictor Agents therapeutic use, Adrenergic beta-Agonists adverse effects, Adrenergic beta-Antagonists adverse effects, Amoxicillin adverse effects, Anaphylaxis chemically induced, Anaphylaxis drug therapy, Anti-Infective Agents adverse effects, Epinephrine adverse effects, Vasoconstrictor Agents adverse effects
Abstract

Increased risk of severe and resistant anaphylactic shock is a rare and not widely known adverse effect of beta-blocker treatment. It is illustrated in a case of refractory anaphylactic shock occurring in a 47-year-old woman who received beta-blockers. Actually, beta-blockers increase the release of anaphylactic mediators, decrease the cardiovascular compensatory changes to the anaphylactic shock and promote paradoxical reflex vagotonic effects when using epinephrine.

Published
2006
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