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1. Clinical outcomes among patients with mitral valve regurgitation undergoing Impella-supported high-risk PCI

Author

Abu-Much, Arsalan, Grines, Cindy L., Chen, Shmuel, Batchelor, Wayne B., Zhao, Duzhi, Falah, Batla, Maini, Aneel S., Redfors, Björn, Bellumkonda, Lavanya, Bharadwaj, Aditya S., Moses, Jeffrey W., Truesdell, Alexander G., Zhang, Yiran, Zhou, Zhipeng, Baron, Suzanne J., Lansky, Alexandra J., Basir, Mir B., O'Neill, William W., and Cohen, David J.

Published
2024
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2. Characteristics and outcomes of patients presenting with acute myocardial infarction and cardiogenic shock during COVID‐19

Author

Ahlers, Michael J, Srivastava, Pratyaksh K, Basir, Mir B, O'Neill, William W, Hacala, Michael, Ammar, Kareem, Khalil, Suzan, Hollowed, John, and Nsair, Ali

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cardiovascular, Prevention, Heart Disease, Heart Disease - Coronary Heart Disease, Clinical Research, Good Health and Well Being, COVID-19, Female, Heart-Assist Devices, Humans, Middle Aged, Myocardial Infarction, Pandemics, Percutaneous Coronary Intervention, ST Elevation Myocardial Infarction, Shock, Cardiogenic, Treatment Outcome, United States, acute myocardial infarction/STEMI, coronary artery disease, intervention, mechanical circulatory support, ECMO/IABP/tandem/Impella, shock, cardiogenic, coronary artery disease, intervention, mechanical circulatory support, ECMO/IABP/tandem/Impella, shock, cardiogenic, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

ObjectivesTo evaluate characteristics and outcomes of patients presenting with acute myocardial infarction and cardiogenic shock (AMICS) during the coronavirus disease 2019 (COVID-19) pandemic.BackgroundThe COVID-19 pandemic has created challenges in delivering acute cardiovascular care. Quality measures and outcomes of patients presenting with AMICS during COVID-19 in the United States have not been well described.MethodsWe identified 406 patients from the National Cardiogenic Shock Initiative (NCSI) with AMICS and divided them into those presenting before (N = 346, 5/9/2016-2/29/2020) and those presenting during the COVID-19 pandemic (N = 60, 3/1/2020-11/10/2020). We compared baseline clinical data, admission characteristics, and outcomes.ResultsThe median age of the cohort was 64 years, and 23.7% of the group was female. There were no significant differences in age, sex, and medical comorbidities between the two groups. Patients presenting during the pandemic were less likely to be Black compared to those presenting prior. Median door to balloon (90 vs. 88 min, p = 0.38), door to support (88 vs. 78 min, p = 0.13), and the onset of shock to support (74 vs. 62 min, p = 0.15) times were not significantly different between the two groups. Patients presented with ST-elevation myocardial infarction more often during the COVID-19 period (95.0% vs. 80.0%, p = 0.005). In adjusted logistic regression models, COVID-19 period did not significantly associate with survival to discharge (odds ratio [OR] 1.09, 95% confidence interval [CI] 0.54-2.19, p = 0.81) or with 1-month survival (OR 0.82, 95% CI 0.42-1.61, p = 0.56).ConclusionsCare of patients presenting with AMICS has remained robust among hospitals participating in the NCSI during the COVID-19 pandemic.

Published
2022

4. Temporary mechanical circulatory support in infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials with 6-month follow-up

Author

Burkhoff, Daniel, Cohen, Howard, Brunckhorst, Corinna, O'Neill, William W., Thiele, Holger Thiele, Sick, Peter, Boudriot, Enno, Diederich, Klaus-Werner, Hambrecht, Rainer, Niebauer, Josef, Schuler, Gerhard, Seyfarth, Melchior, Sibbing, Dirk, Bauer, Iris, Fröhlich, Georg, Bott-Flügel, Lorenz, Byrne, Robert, Dirschinger, Josef, Kastrati, Adnan, Schömig, Albert, Ouweneel, Dagmar M., Eriksen, Erlend, Sjauw, Krischan D., van Dongen, Ivo M., Hirsch, Alexander, Packer, Erik J.S, Vis, M. Marie, Wykrzykowska, Joanna J., Koch, Karel T., Baan, Jan, De Winter, Robbert J, Piek, Jan J., Lagrand, Wim K, de Mol, Bas A.J.M, Tijssen, Jan G.P., Henriques, José P.S., Møller, Jacob E., Engstrøm, Thomas, Jensen, Lisette Okkels, Eiskjær, Hans, Mangner, Norman, Polzin, Amin, Schulze, P. Christian, Skurk, Carsten, Nordbeck, Peter, Clemmensen, Peter, Panoulas, Vasileios, Zimmer, Sebastian, Schäfer, Andreas, Werner, Nikos, Frydland, Martin, Holmvang, Lene, Kjærgaard, Jesper, Sørensen, Rikke, Lønborg, Jacob, Greve, Matias, Christiansen, Evald H., Linke, Axel, Woitek, Felix J., Westenfeld, Ralf, Moebius-Winkler, Sven, Wachtell, Kristian, Ravn, Hanne Berg, Lassen, Jens Flensted, Boesgaard, Søren, Gerke, Oke, Hassager, Christian, Lackermair, Korbinian, Brunner, Stefan, Orban, Mathias, Peterss, Sven, Orban, Martin, Theiss, Hans D., Huber, Bruno C., Juchem, Gerd, Born, Frank, Boulesteix, Anne-Laure, Bauer, Axel, Pichlmaier, Maximilian, Hausleiter, Jörg, Massberg, Steffen, Hagl, Christian, Guenther, Sabina P.W., Ostadal, Petr, Rokyta, Richard, Karasek, Jiri, Kruger, Andreas, Vondrakova, Dagmar, Janotka, Marek, Naar, Jan, Smalcova, Jana, Hubatova, Marketa, Hromadk, Milan, Volovar, Stefan, Seyfrydova, Miroslava, Jarkovsky, Jiri, Svoboda, Michal, Linhart, Ales, Belohlavek, Jan, Banning, Amerjeet S., Sabaté, Manel, Gracey, Jay, López-Sobrino, Teresa, Bogaerts, Kris, Adriaenssens, Tom, Berry, Colin, Erglis, Andrejs, Haine, Steven, Myrmel, Truls, Patel, Sameer, Buera, Irene, Sionis, Alessandro, Vilalta, Victoria, Yusuff, Hakeem, Vrints, Christiaan, Adlam, David, Flather, Marcus, Gershlick, Anthony H., Thiele, Holger, Zeymer, Uwe, Akin, Ibrahim, Behnes, Michael, Rassaf, Tienush, Mahabadi, Amir-Abbas, Lehmann, Ralf, Eitel, Ingo, Graf, Tobias, Seidler, Tim, Schuster, Andreas, Duerschmied, Daniel, Hennersdorf, Marcus, Fichtlscherer, Stephan, Voigt, Ingo, John, Stefan, Ewen, Sebastian, Tigges, Eike, Nordbeck, Peter Steffen, Bruch, Leonhard, Jung, Christian, Franz, Jutta, Lauten, Philipp, Goslar, Tomaz, Feistritzer, Hans-Josef, Pöss, Janine, Kirchhof, Eva, Ouarrak, Taoufik, Schneider, Steffen, Desch, Steffen, Freund, Anne, Møller, Jacob E, Henriques, Jose P S, Bogerd, Margriet, Hochadel, Matthias, and Schulze, P Christian

Published
2024
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13. Trends in surgical and transcatheter interventions for tricuspid regurgitation: A national inpatient sample analysis from 2011 to 2020

Author

Villablanca, Pedro, Jabri, Ahmad, Alhuneafat, Laith, Maligireddy, Anand, Rasheed, Waqas, Kapcin, Kyle, Manalo, Katie, Latib, Azeem, Gustino, Gennaro, Fadel, Raef, Al Abdouh, Ahmad, Mhanna, Mohammed, Amoroso, Nicholas, Wang, Dee Dee, O'Neill, Brian, Bagur, Rodrigo, Madanat, Laui, Renard, Brian, Aggarwal, Vikas, Alqarqaz, Mohammad, So, Kent, Genereux, Philippe, Hanson, Ivan D., Abbas, Amr E., and O'Neill, William W.

Published
2024
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14. Outcomes following TAVR in patients with cardiogenic shock: A systematic review and meta-analysis

Author

Jabri, Ahmad, Ayyad, Mohammed, Albandak, Maram, Al-Abdouh, Ahmad, Madanat, Luai, Khalefa, Basma Badrawy, Alhuneafat, Laith, Ayyad, Asem, Lemor, Alejandro, Mhanna, Mohammed, Al Jebaje, Zaid, Fadel, Raef, Gonzalez, Pedro Engel, O'Neill, Brian, Bagur, Rodrigo, Hanson, Ivan D., Abbas, Amr E., Frisoli, Tiberio, Lee, James, Wang, Dee Dee, Aggarwal, Vikas, Alaswad, Khaldoon, O'Neill, William W., Aronow, Herbert D., AlQarqaz, Mohammad, and Villablanca, Pedro

Published
2024
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15. 1-Year Outcomes From the CLASP IID Randomized Trial for Degenerative Mitral Regurgitation

Author

Zahr, Firas, Smith, Robert L., Gillam, Linda D., Chadderdon, Scott, Makkar, Raj, von Bardeleben, Ralph Stephan, Ruf, Tobias Friedrich, Kipperman, Robert M., Rassi, Andrew N., Szerlip, Molly, Goldman, Scott, Inglessis-Azuaje, Ignacio, Yadav, Pradeep, Lurz, Philipp, Davidson, Charles J., Mumtaz, Mubashir, Gada, Hemal, Kar, Saibal, Kodali, Susheel K., Laham, Roger, Hiesinger, William, Fam, Neil P., Keßler, Mirjam, O’Neill, William W., Whisenant, Brian, Kliger, Chad, Kapadia, Samir, Rudolph, Volker, Choo, Joseph, Hermiller, James, Morse, Michael A., Schofer, Niklas, Gafoor, Sameer, Latib, Azeem, Mahoney, Paul, Kaneko, Tsuyoshi, Shah, Pinak B., Riddick, John A., Muhammad, Kamran I., Boekstegers, Peter, Price, Matthew J., Praz, Fabien, Koulogiannis, Konstantinos, Marcoff, Leo, Hausleiter, Jörg, and Lim, D. Scott

Published
2023
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16. 1-Year Outcomes of Transcatheter Edge-to-Edge Repair in Anatomically Complex Degenerative Mitral Regurgitation Patients

Author

Smith, Robert L., Lim, D. Scott, Gillam, Linda D., Zahr, Firas, Chadderdon, Scott, Rassi, Andrew N., Makkar, Raj, Goldman, Scott, Rudolph, Volker, Hermiller, James, Kipperman, Robert M., Dhoble, Abhijeet, Smalling, Richard, Latib, Azeem, Kodali, Susheel K., Lazkani, Mohamad, Choo, Joseph, Lurz, Philipp, O’Neill, William W., Laham, Roger, Rodés-Cabau, Josep, Kar, Saibal, Schofer, Niklas, Whisenant, Brian, Inglessis-Azuaje, Ignacio, Baldus, Stephan, Kapadia, Samir, Szerlip, Molly, Kliger, Chad, Boone, Robert, Webb, John G., Williams, Mathew R., von Bardeleben, Ralph Stephan, Ruf, Tobias Friedrich, Guerrero, Mayra, Eleid, Mackram, McCabe, James M., Davidson, Charles, Hiesinger, William, Kaneko, Tsuyoshi, Shah, Pinak B., Yadav, Pradeep, Koulogiannis, Konstantinos, Marcoff, Leo, and Hausleiter, Jörg

Published
2023
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17. 3D Printing, Computational Modeling, and Artificial Intelligence for Structural Heart Disease

Author

Wang, Dee Dee, Qian, Zhen, Vukicevic, Marija, Engelhardt, Sandy, Kheradvar, Arash, Zhang, Chuck, Little, Stephen H, Verjans, Johan, Comaniciu, Dorin, O'Neill, William W, and Vannan, Mani A

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Research, Bioengineering, Heart Disease, Cardiovascular, Good Health and Well Being, Artificial Intelligence, Cardiac Catheterization, Cardiac Surgical Procedures, Heart Diseases, Humans, Predictive Value of Tests, Printing, Three-Dimensional, 3D printing, artificial intelligence, computational modeling, computed tomography, left atrial appendage, structural heart disease, transcatheter aortic valve replacement, transcatheter mitral valve replacement, transesophageal echocardiogram, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Structural heart disease (SHD) is a new field within cardiovascular medicine. Traditional imaging modalities fall short in supporting the needs of SHD interventions, as they have been constructed around the concept of disease diagnosis. SHD interventions disrupt traditional concepts of imaging in requiring imaging to plan, simulate, and predict intraprocedural outcomes. In transcatheter SHD interventions, the absence of a gold-standard open cavity surgical field deprives physicians of the opportunity for tactile feedback and visual confirmation of cardiac anatomy. Hence, dependency on imaging in periprocedural guidance has led to evolution of a new generation of procedural skillsets, concept of a visual field, and technologies in the periprocedural planning period to accelerate preclinical device development, physician, and patient education. Adaptation of 3-dimensional (3D) printing in clinical care and procedural planning has demonstrated a reduction in early-operator learning curve for transcatheter interventions. Integration of computation modeling to 3D printing has accelerated research and development understanding of fluid mechanics within device testing. Application of 3D printing, computational modeling, and ultimately incorporation of artificial intelligence is changing the landscape of physician training and delivery of patient-centric care. Transcatheter structural heart interventions are requiring in-depth periprocedural understanding of cardiac pathophysiology and device interactions not afforded by traditional imaging metrics.

Published
2021

19. Randomized Comparison of Transcatheter Edge-to-Edge Repair for Degenerative Mitral Regurgitation in Prohibitive Surgical Risk Patients

Author

Lim, D. Scott, Smith, Robert L., Gillam, Linda D., Zahr, Firas, Chadderdon, Scott, Makkar, Raj, von Bardeleben, Ralph Stephan, Kipperman, Robert M., Rassi, Andrew N., Szerlip, Molly, Goldman, Scott, Inglessis-Azuaje, Ignacio, Yadav, Pradeep, Lurz, Philipp, Davidson, Charles J., Mumtaz, Mubashir, Gada, Hemal, Kar, Saibal, Kodali, Susheel K., Laham, Roger, Hiesinger, William, Fam, Neil P., Keßler, Mirjam, O’Neill, William W., Whisenant, Brian, Kliger, Chad, Kapadia, Samir, Rudolph, Volker, Choo, Joseph, Hermiller, James, Morse, Michael A., Schofer, Niklas, Gafoor, Sameer, Latib, Azeem, Koulogiannis, Konstantinos, Marcoff, Leo, and Hausleiter, Jörg

Published
2022
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22. Improved outcomes in patients with severely depressed LVEF undergoing percutaneous coronary intervention with contemporary practices

Author

O'Neill, William W., Anderson, Mark, Burkhoff, Daniel, Grines, Cindy L., Kapur, Navin K., Lansky, Alexandra J., Mannino, Salvatore, McCabe, James M., Alaswad, Khaldoon, Daggubati, Ramesh, Wohns, David, Meraj, Perwaiz M., Pinto, Duane S., Popma, Jeffrey J., Moses, Jeffrey W., Schreiber, Theodore L., and Magnus Ohman, E.

Published
2022
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25. Clinical Outcomes of Patients Experiencing Transient Loss of Pulse Pressure During High-Risk PCI with Impella.

Author

BASIR, MIR B., BENTLEY, DANA, TRUESDELL, ALEXANDER G., KUNKEL, KATHERINE, LEMOR, ALEJANDRO, MEGALY, MICHAEL, ALQARQAZ, MOHAMMAD, ALASWAD, KHALDOON, KHANDEWAL, AKSHAY, JORTBERG, ELISE, KALRA, SANJOG, KAKI, AMIR, BURKHOFF, DANIEL, MOSES, JEFFREY W., PINTO, DUANE S., STONE, GREGG W., and O'NEILL, WILLIAM W.

Abstract

• Patients experiencing loss of pulse pressure (LOPP) during high-risk percutaneous coronary intervention (HR-PCI) are transiently dependent on mechanical circulatory support (MCS) devices. • LOPP during HR-PCI with Impella was common and occurred more frequently in patients with cardiomyopathy and low systolic blood pressure. LOPP was strongly associated with higher 90-day major adverse cardiac and cerebrovascular events, acute kidney injury, and mortality. • The ongoing randomized PROTECT-IV trial will determine whether Impella CP support during HR-PCI improves early and late clinical outcomes compared with the standard of care. The trial includes a right heart catheterization substudy that should help to define the role of invasive hemodynamics in stratifying and managing patients undergoing HR-PCI. Patients experiencing loss of pulse pressure (LOPP) during high-risk percutaneous coronary intervention (HR-PCI) are transiently dependent on mechanical circulatory support devices. We sought to define the frequency and clinic outcomes of patients who experience LOPP during HR-PCI. Patients enrolled in the PROTECT III study and had automated Impella controller logs capturing real-time hemodynamics were included in this analysis. A LOPP event was defined as a mean pulse pressure on Impella of <20 mm Hg for ≥5 seconds during PCI. Clinical characteristics and outcomes were then compared between those with and without LOPP. Logistic regression identified clinical and hemodynamic predictors of LOPP. We included 302 patients, of whom 148 patients (49%) experienced LOPP. Age, sex, and comorbidities were similar in patients with and without LOPP. Mean baseline systolic blood pressure (118.6 mm Hg vs 129.8 mm Hg; P <.001) and mean arterial pressure (86.9 mm Hg vs 91.6 mm Hg; P =.011) were lower in patients with LOPP, whereas heart rate (78 bpm vs 73 bpm; P =.012) was higher. Anatomical complexity was similar between groups. Patients with LOPP were more likely to experience major adverse cardiac and cerebrovascular events (23.5% vs 8.8%; P =.002), acute kidney injury (10.1% vs 2.6%; P =.030), and death (20.2% vs 7.9%; P =.008) within 90 days. A low baseline systolic blood pressure and cardiomyopathy were the strongest predictors of LOPP (P =.003 and P =.001, respectively). LOPP on Impella during HR-PCI was common and occurred more frequently in patients with cardiomyopathy and a low systolic blood pressure. LOPP was strongly associated with higher 90-day major adverse cardiac and cerebrovascular events, acute kidney injury, and mortality. Condensed Abstract We sought to define the frequency and clinic outcomes of patients who experience LOPP during high-risk percutaneous coronary intervention (HR-PCI). We included 302 patients, of whom 148 (49%) experienced LOPP. Patients with LOPP were more likely to experience major adverse cardiac and cerebrovascular events (23.5% vs 8.8%; P =.002), acute kidney injury (10.1% vs 2.6%; P =.030), and death (20.2% vs 7.9%; P =.008) within 90 days. A low baseline systolic blood pressure and cardiomyopathy were the strongest predictors of LOPP (P =.003 and P =.001, respectively). [ABSTRACT FROM AUTHOR]

Published
2024
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26. Right Ventricular Dysfunction in Patients Undergoing High-Risk PCI with Impella.

Author

ROMMEL, KARL-PHILIPP, BONNET, GUILLAUME, BELLUMKONDA, LAVANYA, LANSKY, ALEXANDRA J., ZHAO, DUZHI, THOMPSON, JULIA B., ZHANG, YIRAN, REDFORS, BJÖRN, LURZ, PHILIPP C., GRANADA, JUAN F., BHARADWAJ, ADITYA S., BASIR, M. BABAR, O'NEILL, WILLIAM W., and BURKHOFF, DANIEL

Abstract

Right ventricular dysfunction (RVD) is an important prognostic factor in several cardiac conditions, including acute and chronic heart failure. The impact of baseline RVD on clinical outcomes of patients undergoing high-risk percutaneous coronary intervention (HRPCI) supported by Impella is unknown. Patients from the single-arm, multicenter PROTECT III study of Impella-supported HRPCI were stratified based on the presence or absence of RVD. RVD was quantitatively assessed by an echocardiography core laboratory and was defined as fractional area change < 35%, tricuspid annular plane systolic excursion < 17 mm or pulsed-wave Doppler S-wave of the lateral tricuspid annulus < 9.5 cm/s. Procedural outcomes, 90-day major adverse cardiac and cerebrovascular events (MACCE: the composite of all-cause mortality, myocardial infarction, stroke/TIA, and repeat revascularization), and 1-year mortality were assessed. Of the 239 patients who underwent RV function assessment, 124 were found to have RVD. Lower left ventricular ejection fraction, higher blood urea nitrogen levels, and more severe RV dilation were independently associated with RVD. The incidence of hypotensive episodes during PCI, the proportion of patients requiring prolonged Impella support, the completeness of revascularization, and the rate of in-hospital mortality did not differ significantly between patients with vs without RVD. However, 90-day MACCE rates were higher in those with RVD, and RVD was a robust predictor of 1-year mortality in multivariable Cox-regression analyses. In patients undergoing HRPCI with Impella, RVD was associated with more advanced biventricular failure. The use of Impella support during HRPCI facilitated effective revascularization, even in those with concomitant RVD. Nevertheless, RVD was associated with unfavorable long-term prognoses. In the PROTECT III study, among the 239 patients undergoing high-risk percutaneous coronary intervention (HRPCI) with Impella, 48% demonstrated normal right ventricular (RV) function, while 52% exhibited RV dysfunction, based on quantitative imaging. Both groups displayed a comparable extent of revascularization, as evaluated by the SYNTAX Score pre- and post-procedure, and similar in-hospital mortality rates. However, patients with RV dysfunction experienced higher rates of 90-day major adverse cardiac and cerebrovascular events (MACCE) as well as higher 1-year mortality rates. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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33. 2-Year Outcomes for Transcatheter Repair in Patients With Mitral Regurgitation From the CLASP Study

Author

Szerlip, Molly, Spargias, Konstantinos S., Makkar, Raj, Kar, Saibal, Kipperman, Robert M., O’Neill, William W., Ng, Martin K.C., Smith, Robert L., Fam, Neil P., Rinaldi, Michael J., Raffel, O. Christopher, Walters, Darren L., Levisay, Justin, Montorfano, Matteo, Latib, Azeem, Carroll, John D., Nickenig, Georg, Windecker, Stephan, Marcoff, Leo, Cohen, Gideon N., Schäfer, Ulrich, Webb, John G., and Lim, D. Scott

Published
2021
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34. Prospective Evaluation of Transseptal TMVR for Failed Surgical Bioprostheses: MITRAL Trial Valve-in-Valve Arm 1-Year Outcomes

Author

Guerrero, Mayra, Pursnani, Amit, Narang, Akhil, Salinger, Michael, Wang, Dee Dee, Eleid, Mackram, Kodali, Susheel K., George, Isaac, Satler, Lowell, Waksman, Ron, Meduri, Christopher U., Rajagopal, Vivek, Inglessis, Ignacio, Palacios, Igor, Reisman, Mark, Eng, Marvin H., Russell, Hyde M., Pershad, Ashish, Fang, Kenith, Kar, Saibal, Makkar, Rajj, Saucedo, Jorge, Pearson, Paul, Bokhary, Ujala, Kaptzan, Tatiana, Lewis, Brad, Tommaso, Carl, Krause, Philip, Thaden, Jeremy, Oh, Jae, Lang, Roberto M., Hahn, Rebecca T., Leon, Martin B., O’Neill, William W., Feldman, Ted, and Rihal, Charanjit

Published
2021
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35. Prospective Study of TMVR Using Balloon-Expandable Aortic Transcatheter Valves in MAC: MITRAL Trial 1-Year Outcomes

Author

Guerrero, Mayra, Wang, Dee Dee, Eleid, Mackram F., Pursnani, Amit, Salinger, Michael, Russell, Hyde M., Kodali, Susheel K., George, Isaac, Bapat, Vinayak N., Dangas, George D., Tang, Gilbert H.L., Inglesis, Ignacio, Meduri, Christopher U., Palacios, Igor, Reisman, Mark, Whisenant, Brian K., Jermihov, Anastasia, Kaptzan, Tatiana, Lewis, Bradley R., Tommaso, Carl, Krause, Philip, Thaden, Jeremy, Oh, Jae K., Douglas, Pamela S., Hahn, Rebecca T., Leon, Martin B., Rihal, Charanjit S., Feldman, Ted, and O’Neill, William W.

Published
2021
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36. Prospective Evaluation of TMVR for Failed Surgical Annuloplasty Rings: MITRAL Trial Valve-in-Ring Arm 1-Year Outcomes

Author

Guerrero, Mayra, Wang, Dee Dee, Pursnani, Amit, Salinger, Michael, Russell, Hyde M., Eleid, Mackram, Chakravarty, Tarun, Ng, Marvin H., Kodali, Susheel K., Meduri, Christopher U., Pershad, Ashish, Satler, Lowell, Waksman, Ron, Palacios, Igor, Smalling, Richard, Reisman, Mark, Gegenhuber, Mary, Kaptzan, Tatiana, Lewis, Brad, Tommaso, Carl, Krause, Philip, Thaden, Jeremy, Oh, Jae, Douglas, Pamela S., Hahn, Rebecca T., Kar, Saibal, Makkar, Raj, Leon, Martin B., Feldman, Ted, Rihal, Charanjit, and O’Neill, William W.

Published
2021
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38. Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection

Author

McCullough, Peter A., Kelly, Ronan J., Ruocco, Gaetano, Lerma, Edgar, Tumlin, James, Wheelan, Kevin R., Katz, Nevin, Lepor, Norman E., Vijay, Kris, Carter, Harvey, Singh, Bhupinder, McCullough, Sean P., Bhambi, Brijesh K., Palazzuoli, Alberto, De Ferrari, Gaetano M., Milligan, Gregory P., Safder, Taimur, Tecson, Kristen M., Wang, Dee Dee, McKinnon, John E., O'Neill, William W., Zervos, Marcus, and Risch, Harvey A.

Published
2021
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43. Angiographic Characteristics and Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention: Insights From the cVAD PROTECT III Study.

Author

Bharadwaj, Aditya S., Abu-Much, Arsalan, Maini, Aneel S., Zhou, Zhipeng, Yanru Li, Batchelor, Wayne B., Grines, Cindy L., Baron, Suzanne J., Redfors, Björn, Lansky, Alexandra J., Basir, Mir B., and O'Neill, William W.

Abstract

BACKGROUND: Prior studies have found that patients with chronic kidney disease (CKD) have worse outcomes following percutaneous coronary intervention (PCI). There are no data about patients with advanced CKD undergoing Impellasupported high-risk PCI. We, therefore, aimed to evaluate angiographic characteristics and clinical outcomes in patients with CKD who received Impella-supported high-risk PCI as part of the catheter-based ventricular assist device PROTECT III study (A Prospective, Multi-Center, Randomized Controlled Trial of the IMPELLA RECOVER LP 2.5 System Versus Intra Aortic Balloon Pump [IABP] in Patients Undergoing Non Emergent High Risk PCI). METHODS: Patients enrolled in the PROTECT III study were analyzed according to their baseline estimated glomerular filtration rate (eGFR). The primary outcome was 90-day major adverse cardiovascular and cerebrovascular events (the composite of all-cause death, myocardial infarction, stroke/transient ischemic attack, and repeat revascularization). RESULTS: Of 1237 enrolled patients, 1052 patients with complete eGFR baseline assessment were evaluated: 586 with eGFR =60 mL/min per 1.73 m2, 190 with eGFR =45 to <60, 105 with eGFR =30 to <45, and 171 with eGFR <30 or on dialysis. Patients with lower eGFR (all groups with eGFR <60) were more frequently females and had a higher prevalence of hypertension, diabetes, anemia, and peripheral artery disease. The baseline Synergy Between PCI With Taxus and Cardiac Surgery score was similar between groups (28.2±12.6 for all groups). Patients with lower eGFR were more likely to have severe coronary calcifications and higher usage of atherectomy. There were no differences in individual PCI-related coronary complications between groups, but the rates of overall PCI complications were less frequent among patients with lower eGFR. Major adverse cardiovascular and cerebrovascular events at 90 days and 1-year mortality were significantly higher among patients with eGFR <30 mL/min per 1.73 m2 or on dialysis. CONCLUSIONS: Patients with advanced CKD undergoing Impella-assisted high-risk PCI tend to have higher baseline comorbidities, severe coronary calcification, and higher atherectomy usage, yet CKD was not associated with a higher rate of immediate PCI-related complications. However, 90-day major adverse cardiovascular and cerebrovascular events and 1-year mortality were significantly higher among patients with eGFR<30 mL/min per 1.73 m2 or on dialysis. Future studies of strategies to improve intermediate and long-term outcomes of these high-risk patients are warranted. [ABSTRACT FROM AUTHOR]

Published
2024
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45. 1-Year Outcomes for Transcatheter Repair in Patients With Mitral Regurgitation From the CLASP Study

Author

Webb, John G., Hensey, Mark, Szerlip, Molly, Schäfer, Ulrich, Cohen, Gideon N., Kar, Saibal, Makkar, Raj, Kipperman, Robert M., Spargias, Konstantinos, O’Neill, William W., Ng, Martin K.C., Fam, Neil P., Rinaldi, Michael J., Smith, Robert L., Walters, Darren L., Raffel, Christopher O., Levisay, Justin, Latib, Azeem, Montorfano, Matteo, Marcoff, Leo, Shrivastava, Maithili, Boone, Robert, Gilmore, Suzanne, Feldman, Ted E., and Lim, D. Scott

Published
2020
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48. Multivessel Versus Culprit-Vessel Percutaneous Coronary Intervention in Cardiogenic Shock

Author

Lemor, Alejandro, Basir, Mir B., O'Neill, William W., Patel, Kirit, Kolski, Brian, Schreiber, Theodore, Kaki, Amir, Tehrani, Behnam, Truesdell, Alexander G., Lasorda, David, Bharadwaj, Aditya, Hanson, Ivan, Almany, Steve, Timmis, Steven, Dixon, Simon, Lalonde, Thomas, Attallah, Antonious, Todd, Josh, Marso, Steve, Wilkins, Charles, Patel, Nainesh, Senter, Shaun, McRae, Thomas, Rahman, Ayaz, Gelormini, Joseph, Kapur, Navin, Singh, Inder M., Riley, Robert, O'Neill, Brian, Overly, Tijuan, Sharma, Rahul, Dupont, Allison, Green, Michael, Lim, Michael, Khuddus, Matheen, Caputo, Christopher, Larkin, Timothy, Askari, Raza, Nsair, Ali, Akhtar, Yasir, Lin, Lang, McAllister, David, Finley, John, Goldsweig, Andrew, Park, James, Gorwara, Simon, Nazir, Raja, Martin, Scott, Foster, Malcolm, Smith, Craig, Rangaswamy, Chandhiran, Zuberi, Omer, Federici, Robert, Baker, John, Cawich, Ian, Korpas, Denes, Srivastava, Nalin, Aronow, Herbert D., Schaeffer, Michael, Wohns, David, Belford, P. Matthew, Mehra, Aditya, Blank, Nimrod, Alraies, M. Chadi, Ashbrook, Michael, Abdel-Hafez, Osama, Khandelwal, Akshay, Alaswad, Khaldoon, Gorgis, Sarah, Johnson, Tyrell, Hacala, Michael, Kapur, Navin K., LaLonde, Thomas, and O'Neill, William

Published
2020
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50. Minimalistic Transcaval TAVR for a Patient With a Small Aorta

Author

Fang, Jonathan X., primary, Giustino, Gennaro, additional, Wang, Dee Dee, additional, O’Neill, Brian P., additional, Gonzalez, Pedro E., additional, Lee, James C., additional, Frisoli, Tiberio M., additional, O’Neill, William W., additional, and Villablanca, Pedro A., additional

Published
2024
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