921 results on '"Örtegren, A."'
Search Results
2. Risk Factors for Infection After Transrectal Prostate Biopsy: A Population-based Register Study
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Joakim Örtegren, Kimia Kohestani, Olof Elvstam, Håkan Janson, Daniel Åberg, Henrik Kjölhede, Gunnar Kahlmeter, and Ola Bratt
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Prostate biopsy ,Transrectal ,Risk factor ,Infection ,Register study ,Population-based ,Diseases of the genitourinary system. Urology ,RC870-923 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background and objective: Infection after transrectal prostate biopsy (TPBx) is a well-known risk. A comprehensive investigation of risk factors may identify measures for safe TPBx as an alternative to a change in biopsy route. The aim of this study was to identify risk factors for infection after TPBx. Methods: We included all outpatient TPBx cases in Region Kronoberg, Sweden, from January 2010 to December 2019. The primary outcome was post-TPBx infection, defined as prescription of antibiotics indicated for urinary tract infection (UTI) or inpatient care for infection within 30 d. We analysed the following factors in relation to post-TPBx infection: age, diabetes mellitus, prostate cancer diagnosed at index biopsy, previous prostate biopsy, two or more biopsies in the past 24 mo, a positive urine culture, two or more negative urine cultures (UCs) in the past 24 mo, antibiotic treatment grouped as four types, and medication for benign prostatic hyperplasia (BPH). Logistic regression was used to calculate odds ratios (ORs). Key findings and limitations: Of 5788 TPBx procedures in 4040 patients, 405 (7.0%) led to an infection and 170 (2.9%) to inpatient care for infection. Risk factors for post-TPBx infection (ORs 1.5–2.5) were diabetes mellitus, antibiotic treatment for a UTI, fluoroquinolone treatment, and a positive urine culture. Weaker risk factors (ORs 1.3–1.5) were non-UTI antibiotic treatment, BPH medication, and negative UCs before TPBx. Conclusions and clinical implications: Our results confirm that diabetes mellitus and previous UTI are risk factors for infection after TPBx. Lower urinary tract symptoms and treatment with any kind of antibiotic were associated with infection, which has not been previously reported. Patient summary: In a large population-based study from Sweden, we investigated which clinical factors increase the risk of an infection after transrectal prostate biopsy. Our results confirm that diabetes and a previous urinary tract infection are risk factors. We also found two new factors associated with the risk of infection after biopsy: lower urinary tract symptoms and any antibiotic treatment.
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- 2024
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3. Pathways to Professional Digital Competence to Teach for Digital Citizenship: Social Science Teacher Education in Flux
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Alex Örtegren and Anders D. Olofsson
- Abstract
Increasingly pervasive digital technologies in societies are placing complex demands on the development of young people's digital citizenship and digital competence. Social science education and teacher education (TE) play important, but poorly understood, roles in this development. Through reflexive thematic analysis of semi-structured interviews, this paper explores 15 Swedish teacher educators' (TEDs) views of teaching for digital citizenship, particularly social science TE's role. We also consider organisational and personal conditions that may influence TEDs' views of professional digital competence (PDC) for such teaching. Their views are examined through a postdigital lens, with a focus on democratic implications in evolving socio-technical environments. The results indicate that TEDs acknowledge the importance of social science TE in teaching for digital citizenship, but find maintaining responsiveness to societal changes challenging. Challenges are also posed by the multidisciplinary character of social science education, including how personal trajectories shape TEDs' views of their dual-didactic task of teaching to teach for digital citizenship. This paper contributes knowledge of how TEDs, as 'street-level bureaucrats' in social science TE, navigate between written and performed education policy in teaching for digital citizenship, with specific attention to the dynamic character of PDC in social science education.
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- 2024
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4. Philosophical Underpinnings of Digital Citizenship through a Postdigital Lens: Implications for Teacher Educators' Professional Digital Competence
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Alex Örtegren
- Abstract
Embedded in society, digital infrastructure has changed citizens' lives. Young people therefore need to develop digital competence and digital citizenship, and schools have an important role in this regard. To prepare new schoolteachers for this role, teacher educators (TEDs) need professional digital competence (PDC) that includes knowledge, competences, and a conceptual understanding to teach teaching for digital citizenship. In light of the limited body of research on theorizing digital citizenship in relation to TEDs' PDC, this paper critically analyzes three conceptualizations of digital citizenship. Being potentially normative and part of the latest phase of development in the field, these conceptualizations could shape TEDs' PDC and practice. In a qualitative content analysis of the selected conceptualizations, this paper uses a postdigital lens to bring into focus and critically analyze aspects of philosophical underpinnings related to socio-technical relations. The results show that conceptualizations of digital citizenship convey different understandings of human--technology relations and the knowledge and competences necessary to exercise digital citizenship. These differences have far-reaching implications for TEDs' PDC in ways that could impact students' opportunities to develop digital competence and digital citizenship. Therefore, TEDs' PDC needs to include a critical understanding of digital citizenship, and the post-pandemic juncture of "new normal" provides opportunities to rethink and reframe PDC. To this end, a postdigital lens can shift the focus to how PDC is contingent on the shifting entanglements in which pedagogical activities are situated and orchestrated, and how these relate to broader issues of injustice in society.
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- 2024
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5. EXPERIENCES OF COMMUNICATION AND INFORMATION FROM HEALTH CARE STAFF REGARDING REPRODUCTIVE HEALTH: A QUALITATIVE STUDY OF FEMALE CHILDHOOD CANCER SURVIVORS IN SWEDEN
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Sofia Nilsson, Sara Örtegren, Ann Thurin-Kjellberg, Marianne Jarfelt, and Stina Järvholm
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delivery of health care ,fertility ,infertility ,psycho-oncology ,survivorship ,qualitative research ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background With increasing number of childhood cancer survivors, there is a growing population of adult survivors that reach reproductive age. Long-term side effects of cancer treatment can include damage to the reproductive organs and lead to premature ovarian failure. The purpose of the study was to examine female childhood cancer survivors’, participating in long-term follow-up, experiences of communication and information regarding fertility and reproductive health outcomes. We also aimed to investigate how they experienced the transition from pediatric to adult health services. Methods Participants for the study were all part of a longitudinal project, identified through the Long-Term Follow-Up Clinic at the Oncology Department at Sahlgrenska University Hospital, Sweden. Fifty-four female childhood cancer survivors treated with chemotherapy and/or radiotherapy before 18 years of age were included between 2016 and 2018. During the years 2018- 2022, twenty-five of the participants reached the age of 25 and were invited to conduct a semi-structured interview. Twenty-two agreed to participate. The interview includes questions about fertility, collaboration with healthcare and communication regarding reproductive options when diagnosed with cancer. Interview data was analysed inductively using a thematic analysis. Results The analysis of the data resulted in three main themes; (1) Communication challenges, (2) Information about potential infertility and (3) Follow-up – a broader perspective, with a total of 9 subthemes. Many of the women expressed lack of information regarding reproductive health and a disappointment in their follow-up. Conclusion It is evident that the young women have felt a lack of information regarding fertility, reproductive health outcomes and options after their cancer treatment. The results of our study also indicate that transition from pediatric health care to adult health care needs to be facilitated and supported.
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- 2024
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6. Design of miniaturized wide band-pass plasmonic filters in MIM waveguides with tailored spectral filtering
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Ebadi, Seyed Morteza, Khani, Shiva, and Örtegren, Jonas
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- 2024
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7. Postdigital Democracy
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Örtegren, Alex, primary
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- 2024
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8. Ultra-compact multifunctional Surface plasmon device with tailored optical responses
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Seyed Morteza Ebadi, Shiva Khani, and Jonas Örtegren
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Plasmonics ,Stub resonator ,Metal-insulator–metal waveguide ,Optical filter ,Perfect absorber ,Plasmon-induced transparency ,Physics ,QC1-999 - Abstract
This paper presents the design and numerical investigation of a novel, tunable, and highly efficient metal–insulator-metal (MIM) plasmonic device specifically designed for near-infrared (NIR) applications. The device leverages strategically placed stub resonators within a MIM waveguide. We introduce two small perturbations, a triangle and a rectangle, to achieve remarkable functional versatility. Comprehensive numerical analysis, employing the finite element method (FEM) and validated by the transmission line method (TLM), demonstrates the working principle and excellent agreement between the approaches. Our simulation-driven approach, utilizing a Genetic Algorithm (GA) for accelerated optimization, was crucial in achieving performance levels difficult or costly to reach through purely experimental methods. The GA enabled efficient exploration of a vast parameter space, iterative refinement of device configurations, and fine-tuning of geometric characteristics. This meticulous optimization allows us to control complex interactions within the simulated structure. The proposed device offers diverse functionalities based on adjusted geometrical parameters, including: A. Flat-top band-pass filtering: Achieving a maximum transmission efficiency of 95.8 % within a compact footprint of 420 nm × 540 nm. B. Dual-band band-pass filtering: Maintaining a high transmission efficiency of 88.4 % within a slightly larger size of 450 nm × 540 nm. C. Triple-band notch filtering: Exhibiting minimum transmission (below 1 %) at specific resonance wavelengths for targeted signal suppression. D. Plasmon-induced transparency (PIT) effect: Offering potential applications in various optical functionalities. And, E. Perfect absorption: Achieving a maximum absorption efficiency of 99.62 %, paving the way for efficient light harvesting and manipulation. This multifunctional plasmonic device excels in its combination of compactness, tunability, and diverse NIR functionalities. It holds promise for miniaturized optical components, integrated photonic circuits, and advanced light-matter interactions. Our findings contribute significantly to the advancement of compact, efficient, and readily manufacturable photonic technologies.
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- 2024
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9. Philosophical underpinnings of digital citizenship through a postdigital lens: Implications for teacher educators’ professional digital competence
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Örtegren, Alex
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- 2024
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10. A qualitative study on self‐image, mental well‐being and fertility among female young adult childhood cancer survivors
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Sara Örtegren, Sofia Nilsson, Marianne Jarfelt, Ann Thurin‐Kjellberg, and Stina Järvholm
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childhood cancer survivors ,fertility ,mental well‐being ,qualitative analysis ,self‐image ,Reproduction ,QH471-489 ,Women. Feminism ,HQ1101-2030.7 - Abstract
Abstract Introduction Young female adult childhood cancer survivors have frequently been reported to be concerned about their health, in particular their future fertility. The aim of this study was to examine how self‐image, mental health and perceptions of the fertility of young female adults are affected by the illness. Methods A qualitative study with interviewer‐administered semistructured questions was performed from May 2018 to October 2020 at Sahlgrenska University Hospital, Sweden. Fourteen women participated in the study. The median age of the participants was 27 (25–31) years. Results The interviews were recorded and analysed inductively by a thematic approach. Forty‐one codes were created, of these 21 initial codes were found to be related to the aim of the present study. Subsequently, four broad themes were created and these were reanalysed and constituted three main themes, resulting in the labelling: ‘An experience for better and worse’, ‘An everyday life similar and yet different from peers’ and ‘An uncertain fertility’, and a relevant number (11) of inclusive subthemes. Participants expressed that the experience of surviving childhood cancer both strengthened and impaired their everyday life and implied the lack of information about fertility. Conclusions Although a long time, over 10 years, had passed since the cancer treatment for all participants, the experiences of the illness were still present in their lives, both for better and worse. Healthcare workers need to keep this complexity in mind when facing young childhood cancer survivors. Thus, there is a need for individualized support regarding fertility and mental health.
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- 2023
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11. Clinical Value of a Routine Urine Culture Prior to Transrectal Prostate Biopsy
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Joakim Örtegren, Anna Wimmerstedt, Daniel Åberg, Håkan Janson, Henrik Kjölhede, Gunnar Kahlmeter, and Ola Bratt
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Prostate ,Biopsy ,Infection ,Urine culture ,Antibiotic resistance ,Diseases of the genitourinary system. Urology ,RC870-923 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Infectious complications after a transrectal prostate biopsy may be severe. In Sweden, a routine culture prior to all prostate biopsies was introduced to enable targeted antimicrobial prophylaxis and reduce postbiopsy infections. Objective: To investigate whether a clinical routine with a urine culture prior to a prostate biopsy and targeted prophylactic antibiotic therapy reduces postbiopsy infections. Design, setting, and participants: In 2015, a site-specific antimicrobial stewardship programme with a urine culture prior to a prostate biopsy was initiated in Region Kronoberg. To evaluate this routine, we designed a population-based register study including all men who had an outpatient prostate biopsy in 2015–2019 and a control period including all men who had a biopsy in 2010–2014, when a urinary culture was obtained only on clinical suspicion. Outcome measurements and statistical analysis: The primary outcome was infectious complications within 10 d and the secondary outcome was a change in antibiotic prophylactic treatment. An infectious complication was defined as prescription of antibiotics for urinary tract infections or admission to hospital for urinary tract infections or sepsis after a biopsy. Results and limitations: The urine culture period included 2971 prostate biopsy procedures, of which 2684 (90%) were preceded by a urine culture. The control period included 2818 procedures, of which 135 (4.8%) were preceded by a urine culture. Infectious complications were slightly more common during the urine culture period (5.0%) than during the control period (4.3%, p = 0.17), as was inpatient care for infections (3.5% vs 2.2%, p = 0.002). The routine identified 5.4% men with asymptomatic bacteriuria. Despite targeted antibiotic treatment (1.5% received a nonfluoroquinolone treatment), the rate of infectious complications (6.3%) was similar to that in the control period. Conclusions: Prebiopsy urine culture did not lead to fewer postbiopsy infections. Other measures are needed to reduce infectious complications after a prostate biopsy. Patient summary: In this report, we evaluated a routine with urine culture prior to a transrectal prostate biopsy and found that it did not lead to fewer infectious complications.
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- 2023
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12. Ultra-compact multifunctional Surface plasmon device with tailored optical responses
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Morteza Ebadi, Seyed, primary, Khani, Shiva, additional, and Örtegren, Jonas, additional
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- 2024
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13. Digital Citizenship and Professional Digital Competence — Swedish Subject Teacher Education in a Postdigital Era
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Örtegren, Alex
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- 2022
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14. Dissolving the Dichotomies Between Online and Campus-Based Teaching: a Collective Response to The Manifesto for Teaching Online (Bayne et al. 2020)
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MacKenzie, Alison, Bacalja, Alexander, Annamali, Devisakti, Panaretou, Argyro, Girme, Prajakta, Cutajar, Maria, Abegglen, Sandra, Evens, Marshall, Neuhaus, Fabian, Wilson, Kylie, Psarikidou, Katerina, Koole, Marguerite, Hrastinski, Stefan, Sturm, Sean, Adachi, Chie, Schnaider, Karoline, Bozkurt, Aras, Rapanta, Chrysi, Themelis, Chryssa, Thestrup, Klaus, Gislev, Tom, Örtegren, Alex, Costello, Eamon, Dishon, Gideon, Hoechsmann, Michael, Bucio, Jackeline, Vadillo, Guadalupe, Sánchez-Mendiola, Melchor, Goetz, Greta, Gusso, Helder Lima, Arantes, Janine Aldous, Kishore, Pallavi, Lodahl, Mikkel, Suoranta, Juha, Markauskaite, Lina, Mörtsell, Sara, O’Reilly, Tanya, Reed, Jack, Bhatt, Ibrar, Brown, Cheryl, MacCallum, Kathryn, Ackermann, Cecile, Alexander, Carolyn, Payne, Ameena Leah, Bennett, Rebecca, Stone, Cathy, Collier, Amy, Lohnes Watulak, Sarah, Jandrić, Petar, Peters, Michael, and Gourlay, Lesley
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- 2022
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15. Comparison of different radiographic methods to measure the slip angle in children with slipped capital femoral epiphysis (SCFE).
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Lindell, Mikael, Nilsson, Jens, Herngren, Bengt, Örtegren, Jakob, Stenmarker, Margaretha, Tiderius, Carl Johan, and Michno, Piotr
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FEMORAL epiphysis ,INTRACLASS correlation ,CONFIDENCE intervals ,STATISTICAL reliability ,RADIOGRAPHS - Abstract
Background: The management of patients with slipped capital femoral epiphysis (SCFE) requires imaging diagnostics of good quality and accurate measurement of the degree of slippage. In Sweden, three different radiological methods are commonly used: the calcar femorale method; the Billing method; and the Head-shaft angle described by Southwick. Purpose: To evaluate whether any of the three most common methods used in Sweden to measure the slip angle was more useful and reproducible than the others. Material and Methods: Two experienced orthopaedists measured the slip angle in preoperative hip radiographs. Intra- and inter-observer variability between the two experienced observers and the reported value by clinicians who treated the child with SCFE was evaluated. Results: The intraclass correlation coefficient (ICC) confidence interval (CI) between the two experienced observers and the reporting clinicians overlapped for the three methods. In 37% of the cases, the difference was more than 5° between the experienced observers' measurement and the reported value by clinicians. The two experienced orthopaedists' intra- and inter-observer variability was low. Conclusion: The observer's experience is more important than the method of choice when measuring the slip angle in SCFE. The research group recommends the calcar femorale method due to its feasibility on the versatile and commonly used frog leg lateral view. [ABSTRACT FROM AUTHOR]
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- 2024
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16. US Tornado Outbreak Climatologies Based on Different Definitions of “Outbreak,” 1975–2014
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FOGLIETTI, REBECCA V., MITCHELL, TYLER J., and ORTEGREN, JASON T.
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- 2020
17. Spatiotemporal Variability of Tropical Cyclone Precipitation Using a High-Resolution, Gridded (0.25° × 0.25°) Dataset for the Eastern United States, 1948–2015
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Bregy, Joshua C., Maxwell, Justin T., Robeson, Scott M., Ortegren, Jason T., Soulé, Peter T., and Knapp, Paul A.
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- 2020
18. Porous NiMoO4-NrGO as a Battery-Like Electrode Material for Aqueous Hybrid Supercapacitors
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Shahrzad Arshadi-Rastabi, Rasoul Sarraf-Mamoory, Ghadir Razaz, Nicklas Blomquist, Jonas Örtegren, and Håkan Olin
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porous nanostructure ,deposition method ,NiMoO4-rGO ,biocompatible polymer ,electrochemical performance ,asymmetric supercapacitor of NiMoO4-NrGO//AC ,Technology ,Science - Abstract
Recently, much research has investigated nanocomposites and their properties for the development of energy storage systems. Supercapacitor performance is usually enhanced by the use of porous electrode structures, which produce a larger surface area for reaction. In this work, a biocompatible polymer of starch medium was used to create the porous nanostructure. Two powders, i.e., Nickel molybdate/reduced graphene oxide (NiMoO4-rGO) and Nickel molybdate/nitrogen-doped reduced graphene oxide (NiMoO4-NrGO), were synthesized using the deposition method in a medium containing starch, nickel nitrate salts, sodium molybdate, and graphene oxide powder. In terms of electrochemical performance, the NiMoO4-NrGO electrode displayed a higher specific capacitance, i.e., 932 Fg−1 (466 Cg−1), than the NiMoO4-rGO electrode, i.e., 884 Fg−1 (442 Cg−1), at a current density of 1 Ag−1. In fact, graphene oxide sheets could lose more oxygen groups in the presence of ammonia, resulting in increased electrical conductivity. For the asymmetric supercapacitor of NiMoO4-NrGO//AC, the specific capacitance at 1 Ag−1, energy density, and power density were 101.2 Fg−1 (111.32 Cg−1), 17 Wh kg−1, and 174.4 kW kg−1, respectively. In addition, this supercapacitor material displayed a good cycling stability of over 82%.
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- 2023
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19. Pathways to professional digital competence to teach for digital citizenship : social science teacher education in flux
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Örtegren, Alex, Olofsson, Anders D., Örtegren, Alex, and Olofsson, Anders D.
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Increasingly pervasive digital technologies in societies are placing complex demands on the development of young people’s digital citizenship and digital competence. Social science education and teacher education (TE) play important, but poorly understood, roles in this development. Through reflexive thematic analysis of semi-structured interviews, this paper explores 15 Swedish teacher educators’ (TEDs) views of teaching for digital citizenship, particularly social science TE’s role. We also consider organisational and personal conditions that may influence TEDs’ views of professional digital competence (PDC) for such teaching. Their views are examined through a postdigital lens, with a focus on democratic implications in evolving socio-technical environments. The results indicate that TEDs acknowledge the importance of social science TE in teaching for digital citizenship, but find maintaining responsiveness to societal changes challenging. Challenges are also posed by the multidisciplinary character of social science education, including how personal trajectories shape TEDs’ views of their dual-didactic task of teaching to teach for digital citizenship. This paper contributes knowledge of how TEDs, as ‘street-level bureaucrats’ in social science TE, navigate between written and performed education policy in teaching for digital citizenship, with specific attention to the dynamic character of PDC in social science education.
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- 2024
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20. Highly Stable Cycling of Silicon-Nanographite Aerogel-Based Anode for Lithium-Ion Batteries
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Rohan Patil, Manisha Phadatare, Nicklas Blomquist, Jonas Örtegren, Magnus Hummelgård, Jagruti Meshram, Deepak Dubal, and Håkan Olin
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Chemistry ,QD1-999 - Published
- 2021
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21. Fabrication of Li-Ion Battery Anodes by Cvd Growth of Si Nanoparticles on Nanographite Flakes
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Patil, Rohan, primary, Örtegren, Jonas, additional, Phadatare, Manisha, additional, Hummelgård, Magnus, additional, Blomquist, Nicklas, additional, Berastegui, Pedro, additional, Bäckström, Joakim, additional, Limaye, Santosh, additional, Hernández, Guiomar, additional, Olin, Håkan, additional, Bylund, Dan, additional, and Brandell, Daniel, additional
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- 2024
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22. A Scalable Furnace Technique to Grow Silicon Nanoparticles for High-Performance Li-Ion Battery Anodes
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Patil, Rohan, primary, Phadatare, Manisha, additional, Örtegren, Jonas, additional, Hummelgård, Magnus, additional, Blomquist, Nicklas, additional, Olin, Håkan, additional, Limaye, Santosh, additional, Bäckström, Joakim, additional, Zanghellini, Ezio, additional, Brandell, Daniel, additional, and Hernández, Guiomar, additional
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- 2023
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23. Gaṇeśa Caturthī and the Making of the Aspirational Middle Classes in Rajasthan
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Ortegren, Jennifer D.
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- 2019
24. Tropical cyclone frequency inferred from intra-annual density fluctuations in longleaf pine in Florida, USA
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Mitchell, Tyler J., Knapp, Paul A., and Ortegren, Jason T.
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- 2019
25. Aluminum Alloy Anode with Various Iron Content Influencing the Performance of Aluminum-Ion Batteries
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Ghadir Razaz, Shahrzad Arshadirastabi, Nicklas Blomquist, Jonas Örtegren, Torbjörn Carlberg, Magnus Hummelgård, and Håkan Olin
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Al-ion battery ,99% Al 1% Fe alloy anode ,cycling performance ,corrosion ,oxide film ,Al3Fe particle ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
Considerable research has been devoted to the development of cathode materials for Al-ion batteries, but challenges remain regarding the behavior of aluminum anodes. Inert oxide (Al2O3) film on Al surfaces presents a barrier to electrochemical activity. The structure of the oxide film needs to be weakened to facilitate ion transfer during electrochemical activity. This study addresses oxide film challenges by studying Al alloy anodes with different iron content. The results reveal that using an anode of 99% Al 1% Fe in a cell increases the cycling lifetime by 48%, compared to a 99.99% Al anode. The improvement observed with the 99% Al 1% Fe anode is attributed to its fractional surface area corrosion being about 12% larger than that of a 99.99% Al anode. This is coupled to precipitation of a higher number of Al3Fe particles, which are evenly scattered in the Al matrix of 99% Al 1% Fe. These Al3Fe particles constitute weak spots in the oxide film for the electrolyte to attack, and access to fresh Al. The addition of iron to an Al anode thus offers a cheap and easy route for targeting the oxide passivating film challenge in Al-ion batteries.
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- 2023
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26. Patients’ delay is the major cause for late diagnosis of slipped capital femoral epiphysis
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Örtegren, Jakob, Österman, Johan, and Tiderius, Carl J.
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- 2021
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27. Photoconductivity of acid exfoliated and flash-light-processed MoS2 films
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Renyun Zhang, Magnus Hummelgård, Viviane Forsberg, Henrik Andersson, Magnus Engholm, Thomas Öhlund, Martin Olsen, Jonas Örtegren, and Håkan Olin
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Medicine ,Science - Abstract
Abstract MoS2 has been studied intensively during recent years as a semiconducting material in several fields, including optoelectronics, for applications such as solar cells and phototransistors. The photoresponse mechanisms of MoS2 have been discussed but are not fully understood, especially the phenomenon in which the photocurrent slowly increases. Here, we report on a study of the photoresponse flash-light-processed MoS2 films of different thicknesses and areas. The photoresponse of such films under different light intensities and bias voltages was measured, showing significant current changes with a quick response followed by a slow one upon exposure to pulsed light. Our in-depth study suggested that the slow response was due to the photothermal effect that heats the MoS2; this hypothesis was supported by the resistivity change at different temperatures. The results obtained from MoS2 films with various thicknesses indicated that the minority-carrier diffusion length was 1.36 µm. This study explained the mechanism of the slow response of the MoS2 film and determined the effective thickness of MoS2 for a photoresponse to occur. The method used here for fabricating MoS2 films could be used for fabricating optoelectronic devices due to its simplicity.
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- 2018
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28. Health Impact Assessments and Extreme Weather—Challenges for Environmental Health
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Kintziger, Kristina, Ortegren, Jason, DuClos, Chris, Jordan, Melissa, Smith, Talia, Foglietti, Rebecca, Merritt, Robert, and Donado, Louviminda
- Published
- 2017
29. Philosophical underpinnings of digital citizenship through a postdigital lens: Implications for teacher educators’ professional digital competence
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Örtegren, Alex, primary
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- 2023
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30. Porous NiMoO4-NrGO as a Battery-Like Electrode Material for Aqueous Hybrid Supercapacitors
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Arshadi-Rastabi, Shahrzad, primary, Sarraf-Mamoory, Rasoul, additional, Razaz, Ghadir, additional, Blomquist, Nicklas, additional, Örtegren, Jonas, additional, and Olin, Håkan, additional
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- 2023
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31. Mapping European Association of Urology Guideline Practice Across Europe: An Audit of Androgen Deprivation Therapy Use Before Prostate Cancer Surgery in 6598 Cases in 187 Hospitals Across 31 European Countries
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MacLennan, Steven, primary, Azevedo, Nuno, additional, Duncan, Eilidh, additional, Dunsmore, Jennifer, additional, Fullwood, Louise, additional, Lumen, Nicolaas, additional, Plass, Karin, additional, Ribal, Maria J., additional, Roobol, Monique J., additional, Nieboer, Daan, additional, Schouten, Natasha, additional, Skolarus, Ted A., additional, Smith, Emma Jane, additional, N'Dow, James, additional, Mottet, Nicolas, additional, Briganti, Alberto, additional, Heidegger, Isabel, additional, Resch, Johannes Mischinger Irene, additional, Turba, Simon, additional, Zeder, Robin, additional, Lodeta, Braninimir, additional, Van Praet, Charles, additional, Ghysel, Christophe, additional, Arentsen, Harm C., additional, Beysens, Matthias, additional, Vinckier, Marie-Hélène, additional, Mottrie, Alexandre, additional, de Groote, Ruben, additional, Timev, Aleksandar Ivanov, additional, Georgiev, Marincho Ivanov, additional, Yanev, Krassimir Prodanov, additional, Mladenov, Boris, additional, Ivanov, Atanas Slavchev, additional, Antonov, Petar, additional, Valkanov, Stanislav, additional, Tomašković, Igor, additional, Kulis, Tomislav, additional, Bokarica, Pero, additional, Pavlović, Oliver, additional, Krajina, Vinko, additional, Situm, Marijan, additional, Boban, Toni, additional, Soric, Tomislav, additional, Vidic, Ivan, additional, Benko, Goran, additional, Peršec, Zoran, additional, Sović, Tomislav, additional, Zachoval, Roman, additional, Stejskal, Jiri, additional, Capoun, Otakar, additional, Pitra, Tomáš, additional, Gojdič, Marek, additional, Babjuk, Marek, additional, Novák, Vojtěch, additional, Grepl, Michal, additional, Broul, Marek, additional, Novák, Jan, additional, Lund, Lars, additional, Nordström Joensen, Ulla, additional, Borre, Michael, additional, Veskimäe, Priit, additional, Baum, Peep, additional, Tamm, Toomas, additional, Okas, Rauno, additional, Jämsä, Pyry, additional, Lahdensuo, Kanerva, additional, Siltari, Sirkku, additional, Seikkula, Heikki, additional, Palmberg, Christian, additional, Isotalo, Taina, additional, Fiard, Gaelle, additional, Verrier, Cecile, additional, Wiedemann, Laura, additional, Lecornet, Emilie, additional, Leon, Priscilla, additional, Millet, Clementine, additional, Ponzio, Charles, additional, Ploussard, Guillaume, additional, Xylinas, Evanguelos, additional, Ingels, Alexandre, additional, Bigot, Pierre, additional, Le Corre, Vincent, additional, Audenet, François, additional, Berg, Sebastian, additional, Palisaar, Rein-Jueri, additional, Heidenreich, Axel, additional, Seelemeyer, Felix, additional, Krege, Susanne, additional, Leyh-Bannurah, Sami-Ramzi, additional, Witt, Jörn H., additional, Abdirahman, Ayanle, additional, Truß, Michael C., additional, Kranz, Jennifer, additional, Andreas, Karagiannis, additional, Vassileios, Tzortzis, additional, Andreas, Andreou, additional, Paparidis, Spyridon, additional, Davis, Nikolaos Ferakis Niall F., additional, Keane, Kevin G., additional, Fuentes, Adrian, additional, Scuderi, Simone, additional, Barletta, Francesco, additional, Manfredi, Matteo, additional, Porpiglia, Francesco, additional, Cerruto, Maria Angela, additional, Antonelli, Alessandro, additional, Esperto, Francesco, additional, Rossanese, Marta, additional, Veneziano, Domenico, additional, Castelli, Tommaso, additional, La Rocca, Roberto, additional, Scarcia, Marcello, additional, Mantica, Guglielmo, additional, Rebuffo, Silvia, additional, Pomara, Giorgio, additional, Pavan, Nicola, additional, Silvestri, Tommaso, additional, Reale, Giulio Francesco, additional, Polara, Andrea, additional, Falagario, Ugo Giovanni, additional, Carrieri, Giuseppe, additional, Ferrari, Giovanni, additional, Brausi, Maurizio, additional, Orecchia, Luca, additional, Annino, Filippo, additional, Kazlauskas, Gražvydas, additional, Stavridis, Sotir, additional, Radovic, Nenad, additional, Vukovic, Marko, additional, van der Slot, Margaretha Adriana, additional, Bruins, Harman Maxim, additional, van Oort, Inge, additional, Witjes, Fred, additional, van der Poel, Henk, additional, Beisland, Christian, additional, Lilleåsenm, Gunder, additional, Müller, Stig, additional, Haug, Erik S., additional, Dimmen, Magne, additional, Czech, Anna K., additional, Nyk, Lukasz, additional, Jaskulski, Jaroslaw, additional, Ratajczyk, Krzysztof, additional, Braga, Isaac, additional, Pereira, João, additional, Lúcio, Rui, additional, Pina, João, additional, da Silva, Edgar Miguel Calvo Loureiro Tavares, additional, Furriel, Frederico, additional, Mota, Paulo, additional, Rodrigues, Miguel, additional, Radavoi, George Daniel, additional, Crisan, Nicolae, additional, Andras, Iulia, additional, Robert, Stoica, additional, Bratu, Ovidiu, additional, Surcel, Cristian, additional, Kotov, Sergei, additional, Malkhasyan, Vigen, additional, Petrov, Sergei, additional, Reva, Sergei, additional, Bumbasirevic, Uros, additional, Kováčik, Viktor, additional, Perečinský, Ivan, additional, Rybár, Ľuboš, additional, Šulgan, Ján, additional, Briš, Lukáš, additional, Jursová, Katarína, additional, Chovan, Miroslav, additional, Kička, Tomáš, additional, Taskovska, Milena, additional, Kovačič, Rok, additional, Miklavžina, Andraž, additional, Alvarez-Maestro, Mario, additional, De Castro, Javier Mayor, additional, Aragón-Chamizo, Juan, additional, Sutil, Raquel Sopeña, additional, Perrello, Carmen Garau, additional, Vilaseca, Antoni, additional, Perez, Jorge Huguet, additional, Ovide, Julia Aumatell, additional, Planas, Jacques, additional, Borque-Fernando, Angel, additional, Sánchez-Izquierdo, Elena, additional, Jimenez, Jose Luis Marenco, additional, Lendínez-Cano, Guillermo, additional, Puche-Sanz, Ignacio, additional, Garcia-Baquero, Rodrigo, additional, Esteban, Mario Domínguez, additional, Pérez-Fentes, Daniel, additional, Serván, Patricia Parra, additional, Koskela, Lotta Renström, additional, Stranne, Johan, additional, Scholtz, Bianca, additional, Torbrand, Christian, additional, Wagenius, Magnus, additional, Ugge, Henrik, additional, Örtegren, Joakim, additional, Langenauer, Janine, additional, Zumstein, Valentin, additional, Schmid, Hans Peter, additional, Rieken, Malte, additional, Saba, Karim, additional, Strebel, Raeto T., additional, Mortezavi, Ashkan, additional, Rentsch, Cyrill, additional, Roth, Beat, additional, Eberli, Daniel, additional, Pascal, Oechslin, additional, Auer, Rebecca, additional, John, Hubert, additional, Thalmann, George N., additional, Baltacı, Sümer, additional, Mungan, Aydın, additional, Sözen, Sinan, additional, Cetin, Serhat, additional, Aslan, Guven, additional, Türkeri, Levent, additional, İzol, Volkan, additional, Demirdağ, Çetin, additional, Ozden, Sami Berk, additional, Toktaş, Gökhan, additional, Sarikaya, Şaban, additional, Tinay, İlker, additional, Müezzinoğlu, Talha, additional, Erbatu, Oguzcan, additional, Sagnak, Levent, additional, Akdoğan, Bülent, additional, Can, Cavit, additional, Şahin, Hayrettin, additional, Yazıcı, Cenk Murat, additional, Volkov, Serhii, additional, Shulyak, Olexandr, additional, Douglas, David, additional, Hemmant, Joshua, additional, El-Taji, Omar, additional, Ahmad, Imran, additional, Nalagatla, Sarika, additional, Janebdar, Husay, additional, Veeratterapillay, Rajan, additional, Rai, Bhavan, additional, Conroy, Samantha, additional, Cumberbatch, Marcus, additional, and Malde, Sachin, additional
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- 2023
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32. Mapping European Association of Urology Guideline Practice Across Europe: An Audit of Androgen Deprivation Therapy Use Before Prostate Cancer Surgery in 6598 Cases in 187 Hospitals Across 31 European Countries
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Steven MacLennan, Nuno Azevedo, Eilidh Duncan, Jennifer Dunsmore, Louise Fullwood, Nicolaas Lumen, Karin Plass, Maria J. Ribal, Monique J. Roobol, Daan Nieboer, Natasha Schouten, Ted A. Skolarus, Emma Jane Smith, James N'Dow, Nicolas Mottet, Alberto Briganti, Isabel Heidegger, Johannes Mischinger Irene Resch, Simon Turba, Robin Zeder, Braninimir Lodeta, Charles Van Praet, Christophe Ghysel, Harm C. Arentsen, Matthias Beysens, Marie-Hélène Vinckier, Alexandre Mottrie, Ruben de Groote, Aleksandar Ivanov Timev, Marincho Ivanov Georgiev, Krassimir Prodanov Yanev, Boris Mladenov, Atanas Slavchev Ivanov, Petar Antonov, Stanislav Valkanov, Igor Tomašković, Tomislav Kulis, Pero Bokarica, Oliver Pavlović, Vinko Krajina, Marijan Situm, Toni Boban, Tomislav Soric, Ivan Vidic, Goran Benko, Zoran Peršec, Tomislav Sović, Roman Zachoval, Jiri Stejskal, Otakar Capoun, Tomáš Pitra, Marek Gojdič, Marek Babjuk, Vojtěch Novák, Michal Grepl, Marek Broul, Jan Novák, Lars Lund, Ulla Nordström Joensen, Michael Borre, Priit Veskimäe, Peep Baum, Toomas Tamm, Rauno Okas, Pyry Jämsä, Kanerva Lahdensuo, Sirkku Siltari, Heikki Seikkula, Christian Palmberg, Taina Isotalo, Gaelle Fiard, Cecile Verrier, Laura Wiedemann, Emilie Lecornet, Priscilla Leon, Clementine Millet, Charles Ponzio, Guillaume Ploussard, Evanguelos Xylinas, Alexandre Ingels, Pierre Bigot, Vincent Le Corre, François Audenet, Sebastian Berg, Rein-Jueri Palisaar, Axel Heidenreich, Felix Seelemeyer, Susanne Krege, Sami-Ramzi Leyh-Bannurah, Jörn H. Witt, Ayanle Abdirahman, Michael C. Truß, Jennifer Kranz, Karagiannis Andreas, Tzortzis Vassileios, Andreou Andreas, Spyridon Paparidis, Nikolaos Ferakis Niall F. Davis, Kevin G. Keane, Adrian Fuentes, Simone Scuderi, Francesco Barletta, Matteo Manfredi, Francesco Porpiglia, Maria Angela Cerruto, Alessandro Antonelli, Francesco Esperto, Marta Rossanese, Domenico Veneziano, Tommaso Castelli, Roberto La Rocca, Marcello Scarcia, Guglielmo Mantica, Silvia Rebuffo, Giorgio Pomara, Nicola Pavan, Tommaso Silvestri, Giulio Francesco Reale, Andrea Polara, Ugo Giovanni Falagario, Giuseppe Carrieri, Giovanni Ferrari, Maurizio Brausi, Luca Orecchia, Filippo Annino, Gražvydas Kazlauskas, Sotir Stavridis, Nenad Radovic, Marko Vukovic, Margaretha Adriana van der Slot, Harman Maxim Bruins, Inge van Oort, Fred Witjes, Henk van der Poel, Christian Beisland, Gunder Lilleåsenm, Stig Müller, Erik S. Haug, Magne Dimmen, Anna K. Czech, Lukasz Nyk, Jaroslaw Jaskulski, Krzysztof Ratajczyk, Isaac Braga, João Pereira, Rui Lúcio, João Pina, Edgar Miguel Calvo Loureiro Tavares da Silva, Frederico Furriel, Paulo Mota, Miguel Rodrigues, George Daniel Radavoi, Nicolae Crisan, Iulia Andras, Stoica Robert, Ovidiu Bratu, Cristian Surcel, Sergei Kotov, Vigen Malkhasyan, Sergei Petrov, Sergei Reva, Uros Bumbasirevic, Viktor Kováčik, Ivan Perečinský, Ľuboš Rybár, Ján Šulgan, Lukáš Briš, Katarína Jursová, Miroslav Chovan, Tomáš Kička, Milena Taskovska, Rok Kovačič, Andraž Miklavžina, Mario Alvarez-Maestro, Javier Mayor De Castro, Juan Aragón-Chamizo, Raquel Sopeña Sutil, Carmen Garau Perrello, Antoni Vilaseca, Jorge Huguet Perez, Julia Aumatell Ovide, Jacques Planas, Angel Borque-Fernando, Elena Sánchez-Izquierdo, Jose Luis Marenco Jimenez, Guillermo Lendínez-Cano, Ignacio Puche-Sanz, Rodrigo Garcia-Baquero, Mario Domínguez Esteban, Daniel Pérez-Fentes, Patricia Parra Serván, Lotta Renström Koskela, Johan Stranne, Bianca Scholtz, Christian Torbrand, Magnus Wagenius, Henrik Ugge, Joakim Örtegren, Janine Langenauer, Valentin Zumstein, Hans Peter Schmid, Malte Rieken, Karim Saba, Raeto T. Strebel, Ashkan Mortezavi, Cyrill Rentsch, Beat Roth, Daniel Eberli, Oechslin Pascal, Rebecca Auer, Hubert John, George N. Thalmann, Sümer Baltacı, Aydın Mungan, Sinan Sözen, Serhat Cetin, Guven Aslan, Levent Türkeri, Volkan İzol, Çetin Demirdağ, Sami Berk Ozden, Gökhan Toktaş, Şaban Sarikaya, İlker Tinay, Talha Müezzinoğlu, Oguzcan Erbatu, Levent Sagnak, Bülent Akdoğan, Cavit Can, Hayrettin Şahin, Cenk Murat Yazıcı, Serhii Volkov, Olexandr Shulyak, David Douglas, Joshua Hemmant, Omar El-Taji, Imran Ahmad, Sarika Nalagatla, Husay Janebdar, Rajan Veeratterapillay, Bhavan Rai, Samantha Conroy, Marcus Cumberbatch, Sachin Malde, Urology, and Public Health
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SDG 3 - Good Health and Well-being ,Urology ,Androgen deprivation therapy ,Guidelines ,Implementation science ,Prostate cancer - Abstract
Background: Evidence-practice gaps exist in urology. We previously surveyed European Association of Urology (EAU) guidelines for strong recommendations underpinned by high-certainty evidence that impact patient experience for which practice variations were suspected. The recommendation “Do not offer neoadjuvant androgen deprivation therapy (ADT) before surgery for patients with prostate cancer” was prioritised for further investigation. ADT before surgery is neither clinically effective nor cost effective and has serious side effects. The first step in improving implementation problems is to understand their extent. A clear picture of practice regarding ADT before surgery across Europe is not available. Objective: To assess current ADT use before prostate cancer surgery in Europe. Design, setting, and participants: This was an observational cross-sectional study. We retrospectively audited recent ADT practices in a multicentre international setting. We used nonprobability purposive sampling, aiming for breadth in terms of low- versus high-volume, academic, versus community and public versus private centres. Outcome measurements and statistical analysis: Our primary outcome was adherence to the ADT recommendation. Descriptive statistics and a multilevel model were used to investigate differences between countries across different factors (volume, centre type, and funding type). Subgroup analyses were performed for patients with low, intermediate, and high risk, and for those with locally advanced prostate cancer. We also collected reasons for nonadherence. Results and limitations: We included 6598 patients with prostate cancer from 187 hospitals in 31 countries from January 1, 2017 to May 1, 2020. Overall, nonadherence was 2%, (range 0–32%). Most of the variability was found in the high-risk subgroup, for which nonadherence was 4% (range 0–43%). Reasons for nonadherence included attempts to improve oncological outcomes or preoperative tumour parameters; attempts to control the cancer because of long waiting lists; and patient preference (changing one's mind from radiotherapy to surgery after neoadjuvant ADT had commenced or feeling that the side effects were intolerable). Although we purposively sampled for variety within countries (public/private, academic/community, high/low-volume), a selection bias toward centres with awareness of guidelines is possible, so adherence rates may be overestimated. Conclusions: EAU guidelines recommend against ADT use before prostate cancer surgery, yet some guideline-discordant ADT use remains at the cost of patient experience and an additional payer and provider burden. Strategies towards discontinuation of inappropriate preoperative ADT use should be pursued. Patient summary: Androgen deprivation therapy (ADT) is sometimes used in men with prostate cancer who will not benefit from it. ADT causes side effects such as weight gain and emotional changes and increases the risk of cardiovascular disease, diabetes, and osteoporosis. Guidelines strongly recommend that men opting for surgery should not receive ADT, but it is unclear how well the guidance is followed. We asked urologists across Europe how patients in their institutions were treated over the past few years. Most do not use ADT before surgery, but this still happens in some places. More research is needed to help doctors to stop using ADT in patients who will not benefit from it.
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- 2023
33. A qualitative study on self‐image, mental well‐being and fertility among female young adult childhood cancer survivors
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Örtegren, Sara, primary, Nilsson, Sofia, additional, Jarfelt, Marianne, additional, Thurin‐Kjellberg, Ann, additional, and Järvholm, Stina, additional
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- 2023
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34. Energy Harvesting Using Wastepaper‐Based Triboelectric Nanogenerators
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Zhang, Renyun, primary, Hummelgård, Magnus, additional, Örtegren, Jonas, additional, Andersson, Henrik, additional, Olsen, Martin, additional, Chen, Wenshuai, additional, Wang, Peihong, additional, Dahlström, Christina, additional, Eivazi, Alireza, additional, and Norgren, Magnus, additional
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- 2023
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35. Clinical Value of a Routine Urine Culture Prior to Transrectal Prostate Biopsy
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Örtegren, Joakim, primary, Wimmerstedt, Anna, additional, Åberg, Daniel, additional, Janson, Håkan, additional, Kjölhede, Henrik, additional, Kahlmeter, Gunnar, additional, and Bratt, Ola, additional
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- 2023
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36. Dietary Sugar Shifts Mitochondrial Metabolism and Small RNA Biogenesis in Sperm
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Ramesh, Rashmi, Skog, Signe, Örkenby, Lovisa, Örtegren Kugelberg, Unn, Nätt, Daniel, Öst, Anita, Ramesh, Rashmi, Skog, Signe, Örkenby, Lovisa, Örtegren Kugelberg, Unn, Nätt, Daniel, and Öst, Anita
- Abstract
Aims: Increasing concentrations of dietary sugar results in a linear accumulation of triglycerides in male Drosophila, while inducing a U-shaped obesity response in their offspring. Here, using a combination of proteomics and small RNA (sRNA) sequencing, we aimed at understanding the molecular underpinning in sperm for such plasticity.Results: Proteomic analysis of seminal vesicles revealed that increasing concentrations of dietary sugar resulted in a bell-shaped induction of proteins involved in metabolic/redox regulation. Using stains and in vivo redox reporter flies, this pattern could be explained by changes in sperm production of reactive oxygen species (ROS), more exactly mitochondria-derived H2O2. By quenching ROS with the antioxidant N-acetyl cysteine and performing sRNA-seq on sperm, we found that sperm miRNA is increased in response to ROS. Moreover, we found sperm mitosRNA to be increased in high-sugar diet conditions (independent of ROS). Reanalyzing our previously published data revealed a similar global upregulation of human sperm mitosRNA in response to a high-sugar diet, suggesting evolutionary conserved mechanisms.Innovation: This work highlights a fast response to dietary sugar in mitochondria-produced H2O2 in Drosophila sperm and identifies redox-sensitive miRNA downstream of this event.Conclusions: Our data support a model where changes in the sperm mitochondria in response to dietary sugar are the primary event, and changes in redox homoeostasis are secondary to mitochondrial ROS production. These data provide multiple candidates for paternal intergenerational metabolic responses as well as potential biomarkers for human male fertility., Funding Agencies|Swedish Research Council [2015-03141]; Ragnar Soderbergs foundation; Knut and Alice Wallenberg foundation [2015.0165]
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- 2023
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37. Philosophical underpinnings of digital citizenship through a postdigital lens : implications for teacher educators’ professional digital competence
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Örtegren, Alex and Örtegren, Alex
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Embedded in society, digital infrastructure has changed citizens’ lives. Young people therefore need to develop digital competence and digital citizenship, and schools have an important role in this regard. To prepare new schoolteachers for this role, teacher educators (TEDs) need professional digital competence (PDC) that includes knowledge, competences, and a conceptual understanding to teach teaching for digital citizenship. In light of the limited body of research on theorizing digital citizenship in relation to TEDs’ PDC, this paper critically analyzes three conceptualizations of digital citizenship. Being potentially normative and part of the latest phase of development in the field, these conceptualizations could shape TEDs’ PDC and practice. In a qualitative content analysis of the selected conceptualizations, this paper uses a postdigital lens to bring into focus and critically analyze aspects of philosophical underpinnings related to socio-technical relations. The results show that conceptualizations of digital citizenship convey different understandings of human–technology relations and the knowledge and competences necessary to exercise digital citizenship. These differences have far-reaching implications for TEDs’ PDC in ways that could impact students’ opportunities to develop digital competence and digital citizenship. Therefore, TEDs’ PDC needs to include a critical understanding of digital citizenship, and the post-pandemic juncture of “new normal” provides opportunities to rethink and reframe PDC. To this end, a postdigital lens can shift the focus to how PDC is contingent on the shifting entanglements in which pedagogical activities are situated and orchestrated, and how these relate to broader issues of injustice in society.
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- 2023
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38. Stress-sensitive dynamics of miRNAs and Elba1 in Drosophila embryogenesis
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Örkenby, Lovisa, Skog, Signe, Ekman, Helen, Gozzo, Alessandro, Örtegren Kugelberg, Unn, Ramesh, Rashmi, Magadi, Srivathsa, Zambanini, Gianluca, Nordin, Anna, Cantù, Claudio, Nätt, Daniel, Öst, Anita, Örkenby, Lovisa, Skog, Signe, Ekman, Helen, Gozzo, Alessandro, Örtegren Kugelberg, Unn, Ramesh, Rashmi, Magadi, Srivathsa, Zambanini, Gianluca, Nordin, Anna, Cantù, Claudio, Nätt, Daniel, and Öst, Anita
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Early-life stress can result in life-long effects that impact adult health and disease risk, but little is known about how such programming is established and maintained. Here, we show that such epigenetic memories can be initiated in the Drosophila embryo before the major wave of zygotic transcription, and higher-order chromatin structures are established. An early short heat shock results in elevated levels of maternal miRNA and reduced levels of a subgroup of zygotic genes in stage 5 embryos. Using a Dicer-1 mutant, we show that the stress-induced decrease in one of these genes, the insulator-binding factor Elba1, is dependent on functional miRNA biogenesis. Reduction in Elba1 correlates with the upregulation of early developmental genes and promotes a sustained weakening of heterochromatin in the adult fly as indicated by an increased expression of the PEV w(m4h) reporter. We propose that maternal miRNAs, retained in response to an early embryonic heat shock, shape the subsequent de novo heterochromatin establishment that occurs during early development via direct or indirect regulation of some of the earliest expressed genes, including Elba1., Funding Agencies|Swedish VR,; Ragnar Soederbergs foundation; Knut Wallenberg foundation
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- 2023
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39. Professionell digital kompetens för att undervisa för ett digitalt medborgarskap : förslag på praktiknära forskning för utveckling av ämneslärarutbildningsprofessionen
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Örtegren, Alex and Örtegren, Alex
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I ett samhälle genomsyrat av digitala teknologier blir det allt viktigare för unga att utveckla och utöva ett digitalt medborgarskap för att agera som medborgare, exempelvis i mötet med fake news, algoritmer och artificiell intelligens. Det digitala medborgarskapet ställer därför nya krav på skolans demokratiuppdrag och hur ämneslärarstudenter förbereds för detta uppdrag. Sådan förberedelse kräver att lärarutbildare har en professionsspecifik digital kompetens som omfattar teoretisk och praktikrelaterad kunskap kopplad till digitalt medborgarskap. Syftet med detta papper är att undersöka hur lärarutbildare ser på sin professionella digitala kompetens (PDK) för att kunna undervisa blivande ämneslärare för ett digitalt medborgarskap och diskutera hur praktiknära forskning kan bidra till att vidareutveckla sådan undervisning. Pappret, som är ett delarbete i en avhandling, utgår ifrån en förståelse av PDK som fyra sammanflätade dimensioner som lärarutbildare behöver för att undervisa för ett digitalt medborgarskap: (1) generisk digital kompetens, (2) ämnesrelaterad, didaktisk digital kompetens, (3) professionsrelaterad digital kompetens och (4) transformativ agens (Gudmundsdottir & Hatlevik, 2018; 2020; cf. Örtegren, 2022). Dessa dimensioner präglas till viss del av temporalitet och plasticitet, varför PDK blir ett koncept i ständig förändring (Almås et al., 2021). Analysen av intervjuer med lärarutbildare visar att deras syn på sin PDK för att undervisa för ett digitalt medborgarskap varierar. Lärarutbildares tidigare erfarenheter, till exempel egen forskning, kan bidra till generisk och delvis ämnesrelaterad PDK. Samtidgt visar resultaten att få lärarutbildare ser sin ämnesdidaktiska PDK som tillräcklig för att möjliggöra för ämneslärarstudenter att stötta elevers utveckling av ett digitalt medborgarskap. Mot bakgrund av resultaten ger pappret förslag på framtida praktiknära forskning som involverar lärarutbildare med fokus på undervisning för ett digitalt medborg
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- 2023
40. A postdigital lens on teaching for digital citizenship : opportunities and challenges for teacher educators’ professional digital competence
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Örtegren, Alex and Örtegren, Alex
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With the past 20 years of increasingly pervasive digital technologies in educational and societal contexts, young people’s development of digital citizenship has become important to participate and act as members of society. To this end, schools have an important role, and new teachers need to be prepared through the support of teacher educators. Focusing on their dual-didactic role, this lightning talk highlights opportunities and challenges for teacher educators’ professional digital competence (PDC) to teach for digital citizenship. Using examples from the Swedish context, the talk highlights tensions in teacher educators’ PDC where their understanding of digital citizenship may be broadly compatible with the postdigital but less nuanced in the context of education. Similarly, teacher educators may have PDC to teach about digital citizenship but feel ill-prepared to teach teaching for digital citizenship, where further complexity comes from the strive to have PDC that is responsive to postdigital developments in society. The lightning talk draws attention to the opportunities of using a postdigital lens to support teacher educators’ PDC to include a deep conceptual understanding of digital citizenship, which is important for the preparation of future teachers and, in turn, young people’s development of digital citizenship.
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- 2023
41. Artificial intelligence in Nordic K-12 education : implications of materials and resources for digital citizenship formation
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Örtegren, Alex, Velander, Johanna, Örtegren, Alex, and Velander, Johanna
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Digital technologies, such as artificial intelligence (AI), increasingly permeate societal contexts, impacting how citizens interact, for example, through datafication and algorithms supported by AI (Hintz et al., 2019). Citizens, therefore, need to develop digital citizenship which includes knowledge and skills to engage critically with AI (Vuorikari et al., 2022). Aspects of digital citizenship are present in Nordic K-12 curricula (Christensen et al., 2021), and while teaching AI in education has broadly drawn attention (Holmes & Tuomi, 2022), it is still unclear what knowledge and skills teachers need to focus on to help young citizens develop their digital citizenship in relation to AI (cf. Markauskaite et al., 2022). In response, numerous frameworks and materials for teaching AI have been developed, which could provide teachers with guidance. In a Nordic context, this paper aims to analyze materials and resources that could influence K-12 teachers’ work of teaching AI as an aspect of the digital competence young people need to develop as part of their digital citizenship. This is done by a close reading of the European Union framework DigComp 2.2 and the Swedish National Agency for Education’s supportive materials available teachers to operationalize the teaching of AI. Using Touretzky et al. (2019) as an analytical node, the paper examines the discursive construction of AI-related knowledge and skills that young citizens need and how teachers can operationalize these through available policy and support materials. The early results highlight tendencies to present AI as a threat to democracy which is why citizens need relevant knowledge and skills. This often reflects instrumentalism rather than a holistic understanding of digital technologies in society or what AI can do. The paper thus highlights the need for teachers to engage with these materials critically. Given the potential implications for citizenship formation, such critical engagement becomes im
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- 2023
42. Seqpac: a framework for sRNA-seq analysis in R using sequence-based counts
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Skog, Signe, Örkenby, Lovisa, Örtegren Kugelberg, Unn, Öst, Anita, Nätt, Daniel, Skog, Signe, Örkenby, Lovisa, Örtegren Kugelberg, Unn, Öst, Anita, and Nätt, Daniel
- Abstract
Motivation: Feature-based counting is commonly used in RNA-sequencing (RNA-seq) analyses. Here, sequences must align to target features (like genes or non-coding RNAs) and related sequences with different compositions are counted into the same feature. Consequently, sequence integrity is lost, making results less traceable against raw data.Small RNA (sRNA) often maps to multiple features and shows an incredible diversity in form and function. Therefore, applying feature-based strategies may increase the risk of misinterpretation. We present a strategy for sRNA-seq analysis that preserves the integrity of the raw sequence making the data lineage fully traceable. We have consolidated this strategy into Seqpac: An R package that makes a complete sRNA analysis available on multiple platforms. Using published biological data, we show that Seqpac reveals hidden bias and adds new insights to studies that were previously analyzed using feature-based counting.We have identified limitations in the concurrent analysis of RNA-seq data. We call it the traceability dilemma in alignment-based sequencing strategies. By building a flexible framework that preserves the integrity of the read sequence throughout the analysis, we demonstrate better interpretability in sRNA-seq experiments, which are particularly vulnerable to this problem. Applying similar strategies to other transcriptomic workflows may aid in resolving the replication crisis experienced by many fields that depend on transcriptome analyses., Funding Agencies|Swedish Research Council [2015-03141]; Knut and Alice Wallenberg Foundation [2015.0165]; Ragnar Soderberg; Swedish Research Council for Sustainable Development [2020-01042]
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- 2023
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43. Wastepaper-based Triboelectric Nanogenerators
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Zhang, Renyun, Hummelgård, Magnus, Örtegren, Jonas, Andersson, Henrik, Olsen, Martin, Eivazihollagh, Alireza, Dahlström, Christina, Norgren, Magnus, Wang, P, Chen, W, Zhang, Renyun, Hummelgård, Magnus, Örtegren, Jonas, Andersson, Henrik, Olsen, Martin, Eivazihollagh, Alireza, Dahlström, Christina, Norgren, Magnus, Wang, P, and Chen, W
- Abstract
nks and toners used for printing contain materials, such as polyester, with strong triboelectric properties to enhance the binding effects, making wastepaper, such as magazines and newspapers, good candidates for triboelectric materials. In this study, we report high- output power triboelectric nanogenerators (TENGs) that utilize wastepaper as triboelectric layers (wastepaper-based triboelectric nanogenerators (WP–TENGs)) [1]. Journal paper and office copy paper wastes are investigated. The results show that the maximum power densities of the WP–TENGs reach 43.5 W·m-2, which is approximately 250 times the previously reported output of the TENG with a recycled triboelectric layer made from wastepaper [2]. The maximum open circuit voltage (VOC) and short circuit current (ISC) are 774 V and 3.92 mA (784 mA m-2), respectively. These findings can be applied to extend the life cycle of printed papers for energy harvesting, and they can later be applied for materials recycling to enhance the sustainable development of our society. [1] Zhang, R., Hummelgård, M., Örtegren, J., Andersson, H., Olsen, M., Chen, W., Wang, P., Eivazi, A., Dahlström, C. & Norgren, M. Adv. Engin. Mater., in press, 2023; https://doi.org/10.1002/adem.202300107 [2] Zhang, Z., Jie, Y., Zhu, J., Zhu, Z., Chen, H, Lu, Q., Zeng, Y., Cao, X., Wang, N. & Wang, Z. Nano Res. 15, 1109, 2022; https://doi.org/10.1007/s12274-021-3612-8
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- 2023
44. Energy Harvesting Using Wastepaper-Based Triboelectric Nanogenerators
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Zhang, Renyun, Hummelgård, Magnus, Örtegren, Jonas, Andersson, Henrik, Olsen, Martin, Chen, Wenshuai, Wang, Peihong, Dahlström, Christina, Eivazi, Alireza, Norgren, Magnus, Zhang, Renyun, Hummelgård, Magnus, Örtegren, Jonas, Andersson, Henrik, Olsen, Martin, Chen, Wenshuai, Wang, Peihong, Dahlström, Christina, Eivazi, Alireza, and Norgren, Magnus
- Abstract
Inks and toners used for printing contain materials, such as polyester, with strong triboelectric properties to enhance the binding effects, making wastepaper, such as magazines and newspapers, good candidates for triboelectric materials. Herein, high-output power triboelectric nanogenerators (TENGs) that utilize wastepaper as triboelectric layers (wastepaper-based triboelectric nanogenerators (WP–TENGs)) are reported. Journal paper and office copy paper wastes are investigated. The results show that the maximum power densities of the WP–TENGs reach 43.5 W m−2, which is approximately 250 times the previously reported output of the TENG with a recycled triboelectric layer made from wastepaper. The maximum open circuit voltage (V OC) and short circuit current (I SC) are 774 V and 3.92 mA (784 mA m−2), respectively. These findings can be applied to extend the life cycle of printed papers for energy harvesting, and they can later be applied for materials recycling to enhance the sustainable development of our society.
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- 2023
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45. Triboelectric nanogenerators with ultrahigh current density enhanced by hydrogen bonding between nylon and graphene oxide
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Zhang, Renyun, Hummelgård, Magnus, Örtegren, Jonas, Andersson, Henrik, Olsen, Martin, Chen, Dabo, Li, Jiayong, Eivazi, Alireza, Dahlström, Christina, Norgren, Magnus, Wang, Zhong Lin, Zhang, Renyun, Hummelgård, Magnus, Örtegren, Jonas, Andersson, Henrik, Olsen, Martin, Chen, Dabo, Li, Jiayong, Eivazi, Alireza, Dahlström, Christina, Norgren, Magnus, and Wang, Zhong Lin
- Abstract
The triboelectric properties of the tribolayers are essential factors affecting the current density of triboelectric nanogenerators (TENGs). To enhance the current density, composites have been developed to tune their triboelectric properties. Previous studies have reported enhanced TENG performance with composite materials, primarily based on their composition, while chemical interactions between the components have been less analyzed. In this study, we report a novel approach to improve the current density of a TENG by introducing dipole-dipole interactions between a nylon filter membrane and graphene oxide (GO) through hydrogen bonds. The Raman spectroscopy confirmed the occurrence of the interactions resulting from hydrogen bonding. The enhancing mechanisms of hydrogen bonds were further analyzed by Kelvin probe force microscope (KPFM) measurement, which demonstrated that hydrogen bonding could influence the surface potential of the coated GO, leading to increased output of the nylon/GO@NFM TENG (NGN-TENG). Our results show that an ultrahigh current density of 1757 mA·m−2 was obtained with a 2 × 2 cm2 NGN-TENG. Additionally, we demonstrated the feasibility of using the NGN-TENG as a motion sensor to sense finger motions. These findings suggest that the introduction of hydrogen bonds in TENG composites can provide a promising route for improving their performance.
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- 2023
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46. Porous NiMoO4-NrGO as a Battery-Like Electrode Material for Aqueous Hybrid Supercapacitors
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Arshadi Rastabi, Shahrzad, Sarraf-Mamoory, R., Razaz, Ghadir, Blomquist, Nicklas, Örtegren, Jonas, Olin, Håkan, Arshadi Rastabi, Shahrzad, Sarraf-Mamoory, R., Razaz, Ghadir, Blomquist, Nicklas, Örtegren, Jonas, and Olin, Håkan
- Abstract
Recently, much research has investigated nanocomposites and their properties for the development of energy storage systems. Supercapacitor performance is usually enhanced by the use of porous electrode structures, which produce a larger surface area for reaction. In this work, a biocompatible polymer of starch medium was used to create the porous nanostructure. Two powders, i.e., Nickel molybdate/reduced graphene oxide (NiMoO4-rGO) and Nickel molybdate/nitrogen-doped reduced graphene oxide (NiMoO4-NrGO), were synthesized using the deposition method in a medium containing starch, nickel nitrate salts, sodium molybdate, and graphene oxide powder. In terms of electrochemical performance, the NiMoO4-NrGO electrode displayed a higher specific capacitance, i.e., 932 Fg−1 (466 Cg−1), than the NiMoO4-rGO electrode, i.e., 884 Fg−1 (442 Cg−1), at a current density of 1 Ag−1. In fact, graphene oxide sheets could lose more oxygen groups in the presence of ammonia, resulting in increased electrical conductivity. For the asymmetric supercapacitor of NiMoO4-NrGO//AC, the specific capacitance at 1 Ag−1, energy density, and power density were 101.2 Fg−1 (111.32 Cg−1), 17 Wh kg−1, and 174.4 kW kg−1, respectively. In addition, this supercapacitor material displayed a good cycling stability of over 82%.
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- 2023
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47. Aluminum Alloy Anode with Various Iron Content Influencing the Performance of Aluminum-Ion Batteries
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Razaz, Ghadir, Arshadi Rastabi, Shahrzad, Blomquist, Nicklas, Örtegren, Jonas, Carlberg, Torbjorn, Hummelgård, Magnus, Olin, Håkan, Razaz, Ghadir, Arshadi Rastabi, Shahrzad, Blomquist, Nicklas, Örtegren, Jonas, Carlberg, Torbjorn, Hummelgård, Magnus, and Olin, Håkan
- Abstract
Considerable research has been devoted to the development of cathode materials for Al-ion batteries, but challenges remain regarding the behavior of aluminum anodes. Inert oxide (Al2O3) film on Al surfaces presents a barrier to electrochemical activity. The structure of the oxide film needs to be weakened to facilitate ion transfer during electrochemical activity. This study addresses oxide film challenges by studying Al alloy anodes with different iron content. The results reveal that using an anode of 99% Al 1% Fe in a cell increases the cycling lifetime by 48%, compared to a 99.99% Al anode. The improvement observed with the 99% Al 1% Fe anode is attributed to its fractional surface area corrosion being about 12% larger than that of a 99.99% Al anode. This is coupled to precipitation of a higher number of Al3Fe particles, which are evenly scattered in the Al matrix of 99% Al 1% Fe. These Al3Fe particles constitute weak spots in the oxide film for the electrolyte to attack, and access to fresh Al. The addition of iron to an Al anode thus offers a cheap and easy route for targeting the oxide passivating film challenge in Al-ion batteries.
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- 2023
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48. Tidiga samordnade insatser i förskolan : En kvalitativ studie om arbetet med en samverkansmodell, ur ett specialpedagogiskt perspektiv
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Örtegren, Emelie, Zackrisson, Frida, Örtegren, Emelie, and Zackrisson, Frida
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Förskolan utgör en viktig roll i att möjliggöra tidiga insatser för en god och likvärdig uppväxt (SOU 2020:46). I denna studie undersöks en tvärprofessionell samverkansmodell för tidiga insatser som kallas Samverkan för Barnets Bästa (SBB)1. Syftet med studien är att undersöka pedagogers2, specialpedagogers och rektorers uppfattning och erfarenheter av arbetet med SBB. Begreppen barn i behov av särskilt stöd, samverkan och tidiga insatser förklaras utifrån rådande styrdokument och tidigare forskning. Kontextens betydelse i korrelation till dessa tre begrepp, lyfts också fram. I avsnittet teori avhandlas studiens specialpedagogiska perspektiv utifrån det relationella och kategoriska perspektivet. Utifrån innehållsanalysen av intervjuerna med studiens nio informanter framkommer det att relationell kompetens och strävan efter ett empatiskt förhållningssätt framhävs som tydliga framgångsfaktorer för samverkan genom SBB. Dock framkommer en osäkerhet kring vad SBB är, när det bör erbjudas och vilka insatser det kan leda till. Denna osäkerhet lyfts framför allt av rektorerna och pedagogerna, medan specialpedagogerna upplevs väl införstådda i samverkansformens funktion. Studiens viktigaste slutsats visar att tidiga samordnade insatser är viktiga för att upptäcka och motverka ohälsa hos yngre barn i förskolan, samtidigt som ett relationellt förhållningssätt hos personer som möter och arbetar med barn är avgörande för hur insatserna initieras och genomförs. Även tillgång till resurser och specialpedagogisk kompetens inom förskolan visar sig vara en avgörande faktor för att upptäcka tidiga tecken på ohälsa hos barn. Fortsatt forskning behövs för att öka kunskapsspridning kring ett specialpedagogiskt perspektiv på förskolans möjligheter och hinder för samverkan genom SBB med fokus på förskolekontextens betydelse.
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- 2023
49. Spatiotemporal Changes in Comfortable Weather Duration in the Continental United States and Implications for Human Wellness
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Knapp, Paul A., Maxwell, Justin T., Ortegren, Jason T., and Soulé, Peter T.
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- 2016
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50. Silicon-Nanographite Aerogel-Based Anodes for High Performance Lithium Ion Batteries
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Phadatare, Manisha, Patil, Rohan, Blomquist, Nicklas, Forsberg, Sven, Örtegren, Jonas, Hummelgård, Magnus, Meshram, Jagruti, Hernández, Guiomar, Brandell, Daniel, Leifer, Klaus, Sathyanath, Sharath Kumar Manjeshwar, and Olin, Håkan
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- 2019
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