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Hippocampal pathology is central to Alzheimer's disease (AD) and other forms of dementia such as frontotemporal lobar degeneration (FTLD). Autopsy studies have shown that certain hippocampal subfields are more vulnerable than others to AD and FTLD pathology, in particular the subiculum and cornu ammonis 1 (CA1). We conducted shape analysis of hippocampi segmented from structural T1 MRI images on clinically diagnosed dementia patients and controls. The subjects included 19 AD and 35 FTLD patients [13 frontotemporal dementia (FTD), 13 semantic dementia (SD), and 9 progressive nonfluent aphasia (PNFA)] and 21 controls. Compared to controls, SD displayed severe atrophy of the whole left hippocampus. PNFA and FTD also displayed atrophy on the left side, restricted to the hippocampal head in FTD. Finally, AD displayed most atrophy in left hippocampal body with relative sparing of the hippocampal head. Consistent with neuropathological studies, most atrophic deformation was found in CA1 and subiculum areas in FTLD and AD.

Quasars form one of the most energetic phenomena in the universe, and can be traced out to very large redshifts. By studying the galaxies which host the active nuclei, important insights can be gained into the processes that trigger and maintain the quasar powerhouse. The evolution rate of the quasar population is furthermore similar to that of ordinary galaxies, which implies a connection between black hole accretion and star formation in the host galaxies. While the properties of quasar host galaxies at low redshift have become better constrained in recent years, less is known about hosts at earlier cosmic epochs. In addition, though radio-quiet quasars are by far more common than their radio-loud counterparts their host galaxies have not been studied to the same extent, in particular not at higher redshifts. An imaging campaign of a large sample of quasars at intermediate redshift (0.4 < z < 0.8) was carried out at optical wavelengths using the Nordic Optical Telescope, and is studied in this thesis together with two smaller samples. The joint material forms more than half of the total number of observed sources in this redshift interval and increases the number of resolved radio-quiet hosts at z>0.4 considerably. The morphology and mean magnitudes are found to be similar for radio-loud and radio-quiet host galaxies. Both types of host are shown to have optical colours as blue as those of present-day late-type spirals and starburst galaxies, which is likely the result of ongoing star formation. With increasing redshift, observations of host galaxies become more difficult. High spatial resolution can be achieved with adaptive optics, but the variation of the point spread function in the near-infrared wavelength band which is most suited for detection is large and rapid. A statistical approach to the problem of characterizing the point spread function has been developed, making use of simulated objects which are matched to the different atmospheric conditions. Bright, compact host galaxies showing signs of merging and interaction were detected in this way for three quasars at z~2.2, which were observed with the ESO 3.6 m telescope. The method is not restricted to host galaxy analysis but can be utilized in other applications as well, provided that the underlying extended source can be described by an analytical model.

Functional deficits seen in several neurodegenerative disorders have been linked with dysfunction in fronto-striatal circuits and with associated shape alterations in striatal structures. The severity of visible white matter changes (WMC) on MRI has been found to correlate with poorer performance on measures of gait and balance. This study aimed to determine whether striatal volume and shape changes were correlated with gait dysfunction.