1,120 results on '"O, Rodriguez"'
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2. On the integrality of \'etale extensions of polynomial rings
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Díaz, Lázaro O. Rodríguez
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Mathematics - Algebraic Geometry ,Mathematics - Commutative Algebra - Abstract
Motivated by a valuation theorem, recently obtained by Rangachev, we study the \'etale extensions $A\subset B$ of polynomial rings over an algebraically closed field of characteristic zero, such that the integral closure $\overline{A}$ is a primary $\overline{A}$-submodule of $B$. We prove that in this case $\overline{A}$ has infinite cyclic divisor class group, where the generator is a prime divisor equal to the complement of $\textrm{Spec}(B)$ in $\textrm{Spec}(\overline{A})$. Moreover, this prime divisor coincides with the ramification divisor of the finite extension $A\subset \overline{A}$. In this situation we carry out Wright's geometric approach for two-dimensional non-integral \'etale extensions. It follows from the work of Miyanishi that $\textrm{Spec}(\overline{A})$ is a smooth affine surface. We show that $\textrm{Spec}(\overline{A})$ is an $\mathbb{A}^{1}$-bundle over $\mathbb{P}^{1}$, more precisely a Danilov-Gizatullin surface of index three. Based on Wright's analysis of which of these affine surfaces can factorize an \'etale morphism of the complex affine plane and his description of its affine coordinate rings, we prove that under the strong assumption that $\overline{A}$ is always a primary $\overline{A}$-submodule of $B$, any two-dimensional complex \'etale extension is integral., Comment: 7 pages. The Lemma 2.3 in the previous version was wrong. We have conditioned the results accordingly
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- 2024
3. Impacts of seasonality and parasitism on honey bee population dynamics
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Chen, Jun, Rincon, Jordy O Rodriguez, DeGrandi-Hoffman, Gloria, Fewell, Jennifer, Harrison, Jon, and Kang, Yun
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Quantitative Biology - Populations and Evolution ,Mathematics - Dynamical Systems - Abstract
The honeybee plays an extremely important role in ecosystem stability and diversity and in the production of bee pollinated crops. Honey bees and other pollinators are under threat from the combined effects of nutritional stress, parasitism, pesticides, and climate change that impact the timing, duration, and variability of seasonal events. To understand how parasitism and seasonality influence honey bee colonies separately and interactively, we developed a non-autonomous nonlinear honeybee-parasite interaction differential equation model that incorporates seasonality into the egg-laying rate of the queen. Our theoretical results show that parasitism negatively impacts the honey bee population either by decreasing colony size or destabilizing population dynamics through supercritical or subcritical Hopf-bifurcations depending on conditions. Our bifurcation analysis and simulations suggest that seasonality alone may have positive or negative impacts on the survival of honey bee colonies. More specifically, our study indicates that (1) the timing of the maximum egg-laying rate seems to determine when seasonality has positive or negative impacts; and (2) when the period of seasonality is large it can lead to the colony collapsing. Our study further suggests that the synergistic influences of parasitism and seasonality can lead to complicated dynamics that may positively and negatively impact the honey bee colony's survival. Our work partially uncovers the intrinsic effects of climate change and parasites, which potentially provide essential insights into how best to maintain or improve a honey bee colony's health.
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- 2023
4. From the Land to the Seeds: Pedagogies of Liberation
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Clelia O. Rodriguez
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Theory and practice of education ,LB5-3640 - Published
- 2024
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5. \'Etale extensions of polynomial rings are faithfully flat
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Díaz, Lázaro O. Rodríguez
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Mathematics - Commutative Algebra ,Mathematics - Algebraic Geometry - Abstract
We apply Ohi's criterion for faithfully flatness of extensions of commutative rings to prove that any \'etale extension $k[Y_1, \ldots, Y_n]\subseteq k[X_1, \ldots, X_n]$ of polynomial rings (each in $n$ indeterminates) over a commutative ring $k$ is faithfully flat. In particular, if $k$ is an algebraically closed field then any \'etale polynomial map $k^{n} \to k^{n}$ is surjective., Comment: There is a gap in the last step of the proof of Theorem 1.1. The author would like to thank R. van Dobben de Bruyn and Sean Cotner for bringing this point to the author's attention
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- 2022
6. First year of energetic particle measurements in the inner heliosphere with Solar Orbiter's Energetic Particle Detector
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Wimmer-Schweingruber, R. F., Janitzek, N., Pacheco, D., Cernuda, I., Lara, F. Espinosa, Gómez-Herrero, R., Mason, G. M., Allen, R. C., Xu, Z. G., Carcaboso, F., Kollhoff, A., Kühl, P., von Forstner, J. L. Freiherr, Berger, L., Rodriguez-Pacheco, J., Ho, G. C., Andrews, G. B., Angelini, V., Aran, A., Boden, S., Böttcher, S. I., Carrasco, A., Dresing, N., Eldrum, S., Elftmann, R., Evans, V., Gevin, O., Hayes, J., Heber, B., Horbury, T. S., Kulkarni, S. R., Lario, D., Lees, W. J., Limousin, O., Malandraki, O., Martín, C., O'Brien, H., Mateo, M. Prieto, Ravanbakhsh, A., Polo, O. Rodriguez, Prieto, S. Sánchez, Schlemm, C. E., Seifert, H., Terasa, J. C., Tyagi, K., Vainio, R., Walsh, A., and Yedla, M. K.
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Astrophysics - Solar and Stellar Astrophysics ,Physics - Space Physics - Abstract
Solar Orbiter strives to unveil how the Sun controls and shapes the heliosphere and fills it with energetic particle radiation. To this end, its Energetic Particle Detector (EPD) has now been in operation, providing excellent data, for just over a year. EPD measures suprathermal and energetic particles in the energy range from a few keV up to (near-) relativistic energies (few MeV for electrons and about 500 MeV/nuc for ions). We present an overview of the initial results from the first year of operations and we provide a first assessment of issues and limitations. During this first year of operations of the Solar Orbiter mission, EPD has recorded several particle events at distances between 0.5 and 1 au from the Sun. We present dynamic and time-averaged energy spectra for ions that were measured with a combination of all four EPD sensors, namely: the SupraThermal Electron and Proton sensor (STEP), the Electron Proton Telescope (EPT), the Suprathermal Ion Spectrograph (SIS), and the High-Energy Telescope (HET) as well as the associated energy spectra for electrons measured with STEP and EPT. We illustrate the capabilities of the EPD suite using the 10-11 December 2020 solar particle event. This event showed an enrichment of heavy ions as well as $^3$He, for which we also present dynamic spectra measured with SIS. The high anisotropy of electrons at the onset of the event and its temporal evolution is also shown using data from these sensors. We discuss the ongoing in-flight calibration and a few open instrumental issues using data from the 21 July and the 10-11 December 2020 events and give guidelines and examples for the usage of the EPD data. We explain how spacecraft operations may affect EPD data and we present a list of such time periods in the appendix. A list of the most significant particle enhancements as observed by EPT during this first year is also provided.
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- 2021
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7. A Machine Learning Approach to Microwave Sensing for Non-Invasive Alzheimer's Disease Early Detection.
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Leonardo Cardinali, Mattia Spano, Martina Gugliermino, David O. Rodriguez-Duarte, Marco Ricci 0004, Jorge A. Tobon Vasquez, Roberta Palmeri, Rosa Scapaticci, Lorenzo Crocco, and Francesca Vipiana
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- 2023
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8. Review of Microwave Near-Field Sensing and Imaging Devices in Medical Applications
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Cristina Origlia, David O. Rodriguez-Duarte, Jorge A. Tobon Vasquez, Jean-Charles Bolomey, and Francesca Vipiana
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biological tissues ,blood glucose monitoring ,breast imaging ,dielectric measurements ,brain imaging ,microwave sensing ,Chemical technology ,TP1-1185 - Abstract
Microwaves can safely and non-destructively illuminate and penetrate dielectric materials, making them an attractive solution for various medical tasks, including detection, diagnosis, classification, and monitoring. Their inherent electromagnetic properties, portability, cost-effectiveness, and the growth in computing capabilities have encouraged the development of numerous microwave sensing and imaging systems in the medical field, with the potential to complement or even replace current gold-standard methods. This review aims to provide a comprehensive update on the latest advances in medical applications of microwaves, particularly focusing on the near-field ones working within the 1–15 GHz frequency range. It specifically examines significant strides in the development of clinical devices for brain stroke diagnosis and classification, breast cancer screening, and continuous blood glucose monitoring. The technical implementation and algorithmic aspects of prototypes and devices are discussed in detail, including the transceiver systems, radiating elements (such as antennas and sensors), and the imaging algorithms. Additionally, it provides an overview of other promising cutting-edge microwave medical applications, such as knee injuries and colon polyps detection, torso scanning and image-based monitoring of thermal therapy intervention. Finally, the review discusses the challenges of achieving clinical engagement with microwave-based technologies and explores future perspectives.
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- 2024
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9. Urine biomarkers for Alzheimer's disease: A new opportunity for wastewater-based epidemiology?
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Arnoldo Armenta-Castro, Mónica T. Núñez-Soto, Kassandra O. Rodriguez-Aguillón, Alberto Aguayo-Acosta, Mariel Araceli Oyervides-Muñoz, Shane A. Snyder, Damià Barceló, Jayaprakash Saththasivam, Jenny Lawler, Juan Eduardo Sosa-Hernández, and Roberto Parra-Saldívar
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Alzheimer’s disease ,Wastewater-based epidemiology ,Urine molecules ,Alzheimer’s disease Biomarkers ,Proteins ,lncRNAs ,Environmental sciences ,GE1-350 - Abstract
While Alzheimer’s disease (AD) diagnosis, management, and care have become priorities for healthcare providers and researcher’s worldwide due to rapid population aging, epidemiologic surveillance efforts are currently limited by costly, invasive diagnostic procedures, particularly in low to middle income countries (LMIC). In recent years, wastewater-based epidemiology (WBE) has emerged as a promising tool for public health assessment through detection and quantification of specific biomarkers in wastewater, but applications for non-infectious diseases such as AD remain limited. This early review seeks to summarize AD-related biomarkers and urine and other peripheral biofluids and discuss their potential integration to WBE platforms to guide the first prospective efforts in the field. Promising results have been reported in clinical settings, indicating the potential of amyloid β, tau, neural thread protein, long non-coding RNAs, oxidative stress markers and other dysregulated metabolites for AD diagnosis, but questions regarding their concentration and stability in wastewater and the correlation between clinical levels and sewage circulation must be addressed in future studies before comprehensive WBE systems can be developed.
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- 2024
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10. Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study
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Karen J. Bosma, Claudio M. Martin, Karen E. A. Burns, Jordi Mancebo Cortes, Juan Carlos Suárez Montero, Yoanna Skrobik, Kevin E. Thorpe, Andre Carlos Kajdacsy-Balla Amaral, Yaseen Arabi, John Basmaji, Gaëtan Beduneau, Francois Beloncle, Guillaume Carteaux, Emmanuel Charbonney, Alexandre Demoule, Martin Dres, Vito Fanelli, Anna Geagea, Ewan Goligher, François Lellouche, Tommaso Maraffi, Alain Mercat, Pablo O. Rodriguez, Jason Shahin, Stephanie Sibley, Savino Spadaro, Katerina Vaporidi, M. Elizabeth Wilcox, Laurent Brochard, On behalf of the Canadian Critical Care Trials Group and, and the REVA Network
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Proportional assist ventilation ,Work of breathing ,Weaning from mechanical ventilation ,Patient-ventilatory synchrony ,Ventilator-free days ,Medicine (General) ,R5-920 - Abstract
Abstract Background Proportional assist ventilation with load-adjustable gain factors (PAV+) is a mechanical ventilation mode that delivers assistance to breathe in proportion to the patient’s effort. The proportional assistance, called the gain, can be adjusted by the clinician to maintain the patient’s respiratory effort or workload within a normal range. Short-term and physiological benefits of this mode compared to pressure support ventilation (PSV) include better patient-ventilator synchrony and a more physiological response to changes in ventilatory demand. Methods The objective of this multi-centre randomized controlled trial (RCT) is to determine if, for patients with acute respiratory failure, ventilation with PAV+ will result in a shorter time to successful extubation than with PSV. This multi-centre open-label clinical trial plans to involve approximately 20 sites in several continents. Once eligibility is determined, patients must tolerate a short-term PSV trial and either (1) not meet general weaning criteria or (2) fail a 2-min Zero Continuous Positive Airway Pressure (CPAP) Trial using the rapid shallow breathing index, or (3) fail a spontaneous breathing trial (SBT), in this sequence. Then, participants in this study will be randomized to either PSV or PAV+ in a 1:1 ratio. PAV+ will be set according to a target of muscular pressure. The weaning process will be identical in the two arms. Time to liberation will be the primary outcome; ventilator-free days and other outcomes will be measured. Discussion Meta-analyses comparing PAV+ to PSV suggest PAV+ may benefit patients and decrease healthcare costs but no powered study to date has targeted the difficult to wean patient population most likely to benefit from the intervention, or used consistent timing for the implementation of PAV+. Our enrolment strategy, primary outcome measure, and liberation approaches may be useful for studying mechanical ventilation and weaning and can offer important results for patients. Trial registration ClinicalTrials.gov NCT02447692 . Prospectively registered on May 19, 2015.
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- 2023
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11. Multiview Spectral Clustering of High-Dimensional Observational Data
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A. Roman-Messina, Claudia M. Castro-Arvizu, Alejandro Castillo-Tapia, Erlan R. Murillo-Aguirre, and O. Rodriguez-Villalon
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Alternating diffusion maps ,multiview data fusion ,spectral clustering ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
The joint analysis of large-scale datasets is crucial when studying complex processes involving diverse sensing sources and multiple variables. This paper proposes a multiview nonlinear manifold learning framework to fuse or combine data from different types of measurements. Spectral clustering techniques are employed to obtain a low-dimensional system representation, where the physical data are projected onto a low-dimensional Euclidean space that preserves the intrinsic geometry of the data. The theoretical properties of various multiview diffusion maps are examined, and algorithms for the efficient computation of multiview kernel representations are outlined. Measures of similarity are also derived, and the results are compared with other state-of-the-art methods for model reduction. Finally, multiple datasets obtained from transient stability simulations of a large-scale power system model are utilized to evaluate the effectiveness of the developed algorithms, thereby illustrating their superiority over other state-of-the-art multiview clustering approaches.
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- 2023
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12. Failure of First Transition to Pressure Support Ventilation After Spontaneous Awakening Trials in Hypoxemic Respiratory Failure: Influence of COVID-19
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Joaquin Pérez, RT, Matías Accoce, RT, Javier H. Dorado, RT, Daniela I. Gilgado, RT, Emiliano Navarro, RT, Gimena P. Cardoso, RT, Irene Telias, MD, PhD, Pablo O. Rodriguez, MD, PhD, and Laurent Brochard, MD, PhD
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Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
OBJECTIVES:. To describe the rate of failure of the first transition to pressure support ventilation (PSV) after systematic spontaneous awakening trials (SATs) in patients with acute hypoxemic respiratory failure (AHRF) and to assess whether the failure is higher in COVID-19 compared with AHRF of other etiologies. To determine predictors and potential association of failure with outcomes. DESIGN:. Retrospective cohort study. SETTING:. Twenty-eight-bedded medical-surgical ICU in a private hospital (Argentina). PATIENTS:. Subjects with arterial pressure of oxygen (AHRF to Fio2 [Pao2/Fio2] < 300 mm Hg) of different etiologies under controlled mechanical ventilation (MV). INTERVENTIONS:. None. MEASUREMENTS AND MAIN RESULTS:. We collected data during controlled ventilation within 24 hours before SAT followed by the first PSV transition. Failure was defined as the need to return to fully controlled MV within 3 calendar days of PSV start. A total of 274 patients with AHRF (189 COVID-19 and 85 non-COVID-19) were included. The failure occurred in 120 of 274 subjects (43.7%) and was higher in COVID-19 versus non-COVID-19 (49.7% and 30.5%; p = 0.003). COVID-19 diagnosis (odds ratio [OR]: 2.22; 95% CI [1.15–4.43]; p = 0.020), previous neuromuscular blockers (OR: 2.16; 95% CI [1.15–4.11]; p = 0.017) and higher fentanyl dose (OR: 1.29; 95% CI [1.05–1.60]; p = 0.018) increased the failure chances. Higher BMI (OR: 0.95; 95% CI [0.91–0.99]; p = 0.029), Pao2/Fio2 (OR: 0.87; 95% CI [0.78–0.97]; p = 0.017), and pH (OR: 0.61; 95% CI [0.38–0.96]; p = 0.035) were protective. Failure groups had higher 60-day ventilator dependence (p < 0.001), MV duration (p < 0.0001), and ICU stay (p = 0.001). Patients who failed had higher mortality in COVID-19 group (p < 0.001) but not in the non-COVID-19 (p = 0.083). CONCLUSIONS:. In patients with AHRF of different etiologies, the failure of the first PSV attempt was 43.7%, and at a higher rate in COVID-19. Independent risk factors included COVID-19 diagnosis, fentanyl dose, previous neuromuscular blockers, acidosis and hypoxemia preceding SAT, whereas higher BMI was protective. Failure was associated with worse outcomes.
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- 2023
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13. A note on Kirchhoff's theorem for almost complex spheres I
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Díaz, Lázaro O. Rodríguez
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Mathematics - Differential Geometry ,Mathematics - Algebraic Topology ,Mathematics - Symplectic Geometry - Abstract
By a theorem of Kirchhoff if the six sphere admits an almost complex structure then the seven sphere is parallelizable, more crucial, he exhibited an explicit global frame constructed out of the given almost complex structure. This result implicitly equips the seven sphere with a definite H-space multiplication. We propose to address the existence problem of complex structures on the six sphere studying the associated parallelism-multiplications on the seven sphere. We ask to what extent the integrability condition of the almost complex structure amounts to the constancy of the structure functions of the global frame defining the parallelism, i.e, if this parallelism comes from a Lie group structure. At a more fundamental level we inquire if the integrability condition of the almost complex structure entails the homotopy associativity of the induced multiplication. A positive answer to these questions would rule out the six sphere of being a complex manifold since the seven sphere is not a Lie group, not even a homotopy associative H-space.
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- 2018
14. Analysis of the influence of the wind speed profile on wind power production
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C.A. Lopez-Villalobos, O. Martínez-Alvarado, O. Rodriguez-Hernandez, and R. Romero-Centeno
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Vertical wind profile ,Logarithmic profile ,Similarity theory ,Wind resource assessment ,Surface boundary layer ,Power law method ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
The characterization of wind speed and its variability at a site is important for wind resource assessment. The most readily available wind measurements are at 10 m above ground level. These measurements can then be extrapolated vertically to estimate wind power production. In this work, the Monin–Obukhov similarity method was implemented to estimate the wind speed vertical profile within the surface boundary layer for a southeast Mexican site, considering seasonal and diurnal variations of the surface boundary layer stability parameters. Additionally, a power-law method was implemented where the wind shear exponent was set following the International Electrotechnical Commission (IEC) standard and using a variable wind shear exponent. The results showed that the log-law and the variable wind shear method produce better estimates than the IEC standard. The mean power production was estimated at hub height (80 m above surface level) using anemometric data from the Mexican Wind Atlas and then compared with that calculated using the equivalent wind speed estimated from variable wind shear exponent and log-law model. No influence of the vertical wind speed variation within and on top (up to 117.5 m) of the surface boundary layer was found on the mean power production for a wind turbine with a diameter of 90 m and a hub height of 80 m.
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- 2022
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15. A COVID-19 isolation facility for people experiencing homelessness in Berlin, Germany: a retrospective patient record study
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Merle Hörig, Sarah M. Klaes, Svetlana Krasovski-Nikiforovs, Welmoed van Loon, Lukas Murajda, Rosa C. O. Rodriguez, Christine Schade, Anabell Specht, Gabriela Equihua Martinez, Ruth Zimmermann, Frank P. Mockenhaupt, Joachim Seybold, Andreas K. Lindner, and Navina Sarma
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homelessness ,homeless shelter ,isolation and infection control ,COVID-19 ,SARS-CoV-2 ,people experiencing homelessness ,Public aspects of medicine ,RA1-1270 - Abstract
IntroductionPeople experiencing homelessness (PEH) are disproportionately affected by the COVID-19 pandemic. For many PEH it is impossible to isolate due to the lack of permanent housing. Therefore, an isolation facility for SARS-CoV-2 positive PEH was opened in Berlin, Germany, in May 2020, offering medical care, opioid and alcohol substitution therapy and social services. This study aimed to assess the needs of the admitted patients and requirements of the facility.Materials and methodsThis was a retrospective patient record study carried out in the isolation facility for PEH in Berlin, from December 2020 to June 2021. We extracted demographic and clinical data including observed psychological distress from records of all PEH tested positive for SARS-CoV-2 by RT-PCR. Data on duration and completion of isolation and the use of the facilities’ services were analyzed. The association of patients’ characteristics with the completion of isolation was assessed by Student’s t-test or Fisher’s exact test.ResultsA total of 139 patients were included in the study (89% male, mean age 45 years, 41% with comorbidities, 41% non-German speakers). 81% of patients were symptomatic (median duration 5 days, range 1–26). The median length of stay at the facility was 14 days (range 2–41). Among the patients, 80% had non-COVID-19 related medical conditions, 46% required alcohol substitution and 17% opioid substitution therapy. Three patients were hospitalized due to low oxygen saturation. No deaths occurred. Psychological distress was observed in 20%, and social support services were used by 65% of PEH. The majority (82%) completed the required isolation period according to the health authority’s order. We did not observe a statistically significant association between completion of the isolation period and sociodemographic characteristics.ConclusionThe specialized facility allowed PEH a high compliance with completion of the isolation period. Medical care, opioid and alcohol substitution, psychological care, language mediation and social support are essential components to address the specific needs of PEH. Besides contributing to infection prevention and control, isolation facilities may allow better access to medical care for SARS-CoV-2 infected PEH with possibly positive effects on the disease course.
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- 2023
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16. Tracking the Temporal Footprint Effect of Thermonociception and Denervation on the Brain’s Pain Matrix: fMRI and BOLD Study in Rats
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Pellicer F, Ortega-Legaspi JM, Martín R, Solís-Nájera S, Magis-Weinberg L, León-Olea M, Graff-Guerrero A, de la Fuente-Sandoval C, and Alfredo O Rodriguez
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fmri ,resting state ,neuropathic pain ,pain matrix ,chronic pain ,acute pain ,Medicine (General) ,R5-920 - Abstract
Francisco Pellicer,1 Juan M Ortega-Legaspi,2 Rodrigo Martín,3 Sergio Solís-Nájera,4 Lucía Magis-Weinberg,5 Martha León-Olea,6 Ariel Graff-Guerrero,7,8 Camilo de la Fuente-Sandoval,9 Alfredo O Rodriguez3 1Laboratorio de Neurofisiología Integrativa, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, CDMX, México; 2Department of Medicine, Division of Cardiovascular Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; 3Departamento de Ingeniería Eléctrica, Universidad Autónoma Metropolitana Iztapalapa, CDMX, México; 4Departamento de Física, Facultad de Ciencias, Universidad Nacional Autónoma de México, CDMX, México; 5Department of Psychology, University of Washington Guthrie Hall (GTH), Seattle, WA, USA; 6Departamento de Neuromorfología Funcional, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, CDMX, México; 7Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada; 8Department of Psychiatry, University of Toronto, Toronto, ON, Canada; 9Laboratorio de Psiquiatría Experimental, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, CDMX, MéxicoCorrespondence: Francisco Pellicer, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México Xochimilco 101, San Lorenzo Huipulco, Alcaldía Tlalpan, CDMX, 14370, México, Tel +52 55 41605063, Email pellicer@imp.edu.mxObjective: Pain constitutes an essential alarm for preserving the organism’s integrity. Damage to the nervous system produces a pathological condition known as neuropathic pain.Purpose: Blood oxygenation level-dependent (BOLD) and functional magnetic resonance imaging (fMRI) have been widely used to map neuroanatomy and the active regions of interest (ROI) of nociceptive processing. Our study explored the brain’s BOLD response in rats after thermal noxious stimulation, immediately after sciatic nerve damage and during 75 minutes after surgical lesion of the sciatic nerve.Methods: Nine male Wistar rats were tested; the experiments were performed on a 7-Tesla /21-cm Varian Agilent system. This approach allowed, for the first time, to measure in vivo the BOLD changes in brain regions involved with the pain process: cingulated (ACC), somatosensory (S1), and insular cortices (IC), as well as thalamus (Th) and ventral tegmental area (VTA) related with acute thermal pain and during the early stages of sciatic denervation that produce neuropathic pain.Results: During thermonociception scan, all subjects showed BOLD activation in the ROIs determined as ACC, S1, Th, IC and VTA. After denervation, these regions continued to show activation with a slow decrement in intensity for the duration of the experiment. The results suggest that these brain structures are overactive during the genesis of neuropathic pain.Conclusion: The study shows for the first time continuous activation of the pain matrix following an acute thermal nociceptive stimulus followed by neuropathic damage. These results have given insight into the early stages of the development of neuropathic pain in vivo.Keywords: fMRI, resting state, neuropathic pain, pain matrix, chronic pain, acute pain
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- 2022
17. Experimental Assessment of Real-Time Brain Stroke Monitoring via a Microwave Imaging Scanner
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David O. Rodriguez-Duarte, Cristina Origlia, Jorge A. Tobon Vasquez, Rosa Scapaticci, Lorenzo Crocco, and Francesca Vipiana
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Biomedical electromagnetic imaging ,brain stroke monitoring ,distorted born approximation ,flexible antennas ,hemorrhagic stroke ,ischemic stroke ,Telecommunication ,TK5101-6720 - Abstract
This paper presents the experimental validation of a microwave imaging system for real-time monitoring of brain stroke in the post-acute stage. The system exploits a low-complexity sensing apparatus and a multi-frequency microwave imaging algorithm with a novel artifact removal feature. Phantoms of a homogeneous anthropomorphic head and an ellipsoidal non-static stroke mimicking target, varying gradually from 0 cm3 to 60 cm3, are employed for the experiments. The phantom and the evolving target are filled with appropriate alcohol-based mixtures to mimic the different dielectric properties of the relevant tissue. The microwave imaging scanner operates using a 22-antennas architecture formed by printed flexible antennas with a custom-made matching medium. The system provides 3-D images of the entire brain region, exploiting differential multi-view scattering measures and the distorted Born approximation to build a pre-computed imaging kernel. The results show the system’s capability to follow up the continuous progression of hemorrhage and ischemia zones with centimetric spatial resolution and to provide information on whether the stroke is growing or shrinking.
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- 2022
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18. The Solar Orbiter Mission: an Energetic Particle Perspective
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Gómez-Herrero, R., Rodríguez-Pacheco, J., Wimmer-Schweingruber, R. F., Mason, G. M., Sánchez-Prieto, S., Martín, C., Prieto, M., Ho, G. C., Lara, F. Espinosa, Cernuda, I., Blanco, J. J., Russu, A., Polo, O. Rodríguez, Kulkarni, S. R., Terasa, C., Panitzsch, L., Böttcher, S. I., Boden, S., Heber, B., Steinhagen, J., Tammen, J., Köhler, J., Drews, C., Elftmann, R., Ravanbakhsh, A., Seimetz, L., Schuster, B., Yedla, M., Valtonen, E., and Vainio, R.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics ,Physics - Space Physics - Abstract
Solar Orbiter is a joint ESA-NASA mission planed for launch in October 2018. The science payload includes remote-sensing and in-situ instrumentation designed with the primary goal of understanding how the Sun creates and controls the heliosphere. The spacecraft will follow an elliptical orbit around the Sun, with perihelion as close as 0.28 AU. During the late orbit phase the orbital plane will reach inclinations above 30 degrees, allowing direct observations of the solar polar regions. The Energetic Particle Detector (EPD) is an instrument suite consisting of several sensors measuring electrons, protons and ions over a broad energy interval (2 keV to 15 MeV for electrons, 3 keV to 100 MeV for protons and few tens of keV/nuc to 450 MeV/nuc for ions), providing composition, spectra, timing and anisotropy information. We present an overview of Solar Orbiter from the energetic particle perspective, summarizing the capabilities of EPD and the opportunities that these new observations will provide for understanding how energetic particles are accelerated during solar eruptions and how they propagate through the Heliosphere., Comment: XXV ECRS 2016 Proceedings - eConf C16-09-04.3
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- 2017
19. The $SW(3/2,2)$ superconformal algebra via a Quantum Hamiltonian Reduction of $osp(3|2)$
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Díaz, Lázaro O. Rodríguez
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Mathematics - Quantum Algebra ,High Energy Physics - Theory - Abstract
We prove that the family of non-linear $W$-algebras $SW(3/2,2)$ which are extensions of the $N=1$ superconformal algebra by a primary supercurrent of conformal weight $2$ can be realized as a quantum Hamiltonian reduction of the Lie superalgebra $osp(3|2)$. In consequence we obtain an explicit free field realization of the algebra in terms of the screening operators. At central charge $c=12$ the $SW(3/2,2)$ superconformal algebra corresponds to the superconformal algebra associated to sigma models based on eight-dimensional manifolds with special holonomy $Spin(7)$, i.e., the Shatashvili-Vafa $Spin(7)$ superconformal algebra.
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- 2016
20. $\rm G_2$ holonomy manifolds are superconformal
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Díaz, Lázaro O. Rodríguez
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Mathematics - Quantum Algebra ,High Energy Physics - Theory ,Mathematical Physics - Abstract
We study the chiral de Rham complex (CDR) over a manifold $M$ with holonomy $\rm G_2$. We prove that the vertex algebra of global sections of the CDR associated to $M$ contains two commuting copies of the Shatashvili-Vafa $\rm G_2$ superconformal algebra. Our proof is a tour de force, based on explicit computations., Comment: arXiv admin note: text overlap with arXiv:1003.4388 by other authors
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- 2016
21. Gauge theory and G2-geometry on Calabi-Yau links
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Calvo-Andrade, Omegar, Díaz, Lázaro O. Rodríguez, and Earp, Henrique N. Sá
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Mathematics - Differential Geometry ,Mathematical Physics ,53C07, 53C25, 57R15, 32S55, 57R18 (2010) - Abstract
The $7$-dimensional link $K$ of a weighted homogeneous hypersurface on the round $9$-sphere in $\mathbb{C}^5$ has a nontrivial null Sasakian structure which is contact Calabi-Yau, in many cases. It admits a canonical co-closed $\rm G_2$-structure $\varphi$ induced by the Calabi-Yau $3$-orbifold basic geometry. We distinguish these pairs $(K,\varphi)$ by the Crowley-Nordstr\"om $\mathbb{Z}_{48}$-valued $\nu$ invariant, for which we prove odd parity and provide an algorithmic formula. We describe moreover a natural Yang-Mills theory on such spaces, with many important features of the torsion-free case, such as a Chern-Simons formalism and topological energy bounds. In fact compatible $\rm G_2$-instantons on holomorphic Sasakian bundles over $K$ are exactly the transversely Hermitian Yang-Mills connections. As a proof of principle, we obtain $\rm G_2$-instantons over the Fermat quintic link from stable bundles over the smooth projective Fermat quintic, thus relating in a concrete example the Donaldson-Thomas theory of the quintic threefold with a conjectural $\rm G_2$-instanton count., Comment: minor corrections
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- 2016
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22. Adjuvant endocrine therapy for premenopausal women with breast cancer: Patient adherence and physician prescribing practices in Mexico
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Cynthia Villarreal-Garza, Fernanda Mesa-Chavez, Ana S. Ferrigno, Cynthia De la Garza-Ramos, Alan Fonseca, Karen Villanueva-Tamez, Jose Y. Campos-Salgado, Marlid Cruz-Ramos, David O. Rodriguez-Gomez, Sandy Ruiz-Cruz, and Paula Cabrera-Galeana
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Breast cancer ,Endocrine therapy ,Adherence ,Premenopausal ,Prescribing practices ,Mexico ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: In resource-constrained settings, data regarding breast cancer patients' adherence to endocrine therapy (ET) and physicians’ prescribing practices is limited. This study aims to decrease this knowledge gap in a real-world clinical practice. Methods: Premenopausal women with stage 0-III hormone-sensitive breast cancer and receiving adjuvant ET during the past 1–5 years were identified in three Mexican referral centers. Participants' self-reported ET compliance, clinicopathologic characteristics, ET-related knowledge and beliefs, experienced adverse effects, social support, and patient-physician relationships were evaluated. Physician ET prescribing practices were compared with the gold standard according to international and national guidelines to assess clinicians’ adherence to standard-of-care prescription. Results: In total, 95/132 (72%) and 35/132 (27%) participants reported complete and acceptable adherence, respectively. Incomplete adherence was mainly attributed to forgetfulness, adverse effects, and unwillingness to take ET. Being employed/studying (p = 0.042), worrying about long-term ET use (p = 0.031), and experiencing >7 ET-related symptoms (p = 0.018) were associated with incomplete adherence. Guideline-endorsed regimens were prescribed in 84/132 (64%) patients, while the rest should have undergone ovarian function suppression (OFS) but instead received tamoxifen monotherapy. Conclusions: Premenopausal Mexican women self-report remarkably high rates of adequate ET adherence. However, a considerable proportion misses ≥1 doses/month, usually because of forgetfulness. Notably, only 64% receive standard-of-care ET due to suboptimal prescription of OFS. Interventions that remind patients to take their ET, refine physicians’ knowledge on the importance of OFS in high-risk patients, and increase access to OFS could prove pivotal to enhance optimal ET implementation and adherence, which could translate into improved patient outcomes.
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- 2021
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23. Relationship between obstetric history and recurrent urinary infections
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Cynthia Vanaclocha-Ferrer, Barbara-Yolanda Padilla-Fernandez, Magaly-Teresa Marquez-Sanchez, María-Helena Garcia-Sanchez, María-de-la-O Rodriguez-Martin, Nayra Hernandez-Navarro, Cristina Domenech-Perez, Lauro-Sebastián Valverde-Martinez, María-Carmen Flores-Fraile, Misericordia Martínez Huélamo, José-Angel Nieto-Barbero, José-Antonio Miron-Canelo, María-Begoña Garcia-Cenador, and María-Fernanda Lorenzo-Gomez
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Medicine ,Science - Abstract
Abstract Urinary tract infections affect more than 50% of women. 25% derive from recurrent UTI (RUTI). It is not known the relationship between obstetric history and RUTI occurrence. Investigate the relationship between obstetric events and RUTI. Multicenter observational retrospective study. Groups: G.RUTI (n = 294): women with RUTI; G.NON.RUTI (n = 126): women without RUTI (treated and cured of renal cancer). Descriptive statistics, ANOVA analysis of variance (with Scheffe’s test for normal samples and Kruskal–Wallis for other distributions), Fisher's exact test, Pearson and Spearman correlation studies, and multivariate analysis multiple regression were used. Mean age 61.04 years (19–92), G.RUTI: 56.77 years SD 4.46 (19–85). G.NON.RUTI: 71 years SD 6.73 (25–92) (p = 0.0001). Obstetric history: Nulliparous G.RUTI: 20 (3.4%) G.NON.RUTI: 90 (71.42%) p 0.0001; Eutocic G.RUTI: 416 (70.74%) G.NON.RUTI: 30 (23.8%) p 0.0001. Dystocic G.RUTI: 58 (9.86%) G.NON.RUTI: 56 (44.44%) p 0.0001. G.RUTI abortion: 102 (17.34%) G.NON.RUTI: 30 (23.8%) p 0.1381. Hysterectomy without adnexectomy G.RUTI: 100 (17%) G.NON.RUTI: 18 (14.28%) p 0.5640. Hysterectomy with adnexectomy G.RUTI: 100 (17%) G.NON.RUTI: 66 (52.28%) p 0.0001. Nulliparity, dystocic delivery, and hysterectomy with adnexectomy are more frequent in women without RUTI, while eutocic births are more associated with RUTI. The most prevalent gynaecological-obstetric history in women with RUTI is eutocic delivery associated with a good health state.
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- 2021
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24. A New Species of Toad (Anura: Bufonidae: Rhinella) from Northern Peru
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Edgar Lehr, Juan C. Cusi, Lily O. Rodriguez, Pablo J. Venegas, Luis A. García-Ayachi, and Alessandro Catenazzi
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amphibia ,Rhinella festae species Group ,earless ,cloud forest ,Departamento Amazonas ,Departamento San Martín ,Biology (General) ,QH301-705.5 - Abstract
We describe a new species of Rhinella from montane forests between 1788 and 2305 m a.s.l. in the Departamentos Amazonas and San Martín, Peru. We tentatively assign the new species to the Rhinella festae species Group based on morphological similarities with its other 19 members. It is characterised by large size (maximum SVL 91.6 mm in females), a pointed and protruding snout that is posteroventrally inclined, absence of a visible tympanic annulus and tympanic membrane, long parotoid glands in contact with upper eyelid, presence of a dorsolateral row of enlarged tubercles, outer dorsolateral tarsus surface with a subconical ridge of fused tubercles, and absence of subgular vocal sac and vocal slits in males. One specimen from Departamento Amazonas tested positive for Batrachochytrium dendrobatidis.
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- 2021
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25. The Shatashvili-Vafa $G_{2}$ superconformal algebra as a Quantum Hamiltonian Reduction of $D(2,1;\alpha)$
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Heluani, Reimundo and Díaz, Lázaro O. Rodríguez
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Mathematics - Quantum Algebra - Abstract
We obtain the superconformal algebra associated to a sigma model with target a manifold with $G_{2}$ holonomy, i.e., the Shatashvili-Vafa $G_{2}$ algebra as a quantum Hamiltonian reduction of the exceptional Lie superalgebra $D(2,1;\alpha)$ for $\alpha=1$. We produce the complete family of $W$-algebras $SW(\frac{3}{2},\frac{3}{2}, 2)$ (extensions of the $N=1$ superconformal algebra by two primary supercurrents of conformal weight $\frac{3}{2}$ and $2$ respectively) as a quantum Hamiltonian reduction of $D(2,1;\alpha)$. As a corollary we find a free field realization of the Shatashvili-Vafa $G_{2}$ algebra, and an explicit description of the screening operators.
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- 2014
26. Gauge theory and [G.sub.2]-geometry on Calabi--Yau links
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Calvo-Andrade, Omegar, Diaz, Lazaro O. Rodriguez, and Earp, Henrique N. Sa
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- 2020
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27. Benchmark for analysis, modeling and control of ventilation systems in small-scale mine.
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Oscar-O. Rodriguez-Diaz, David Fernando Novella-Rodríguez, Emmanuel Witrant, and Edinson Franco-Mejía
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- 2019
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28. Simultaneous Surface Plasmon Resonance and X-ray Absorption Spectroscopy
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Serrano, A., de la Fuente, O. Rodríguez, Collado, V., Rubio-Zuazo, J., Monton, C., Castro, G., and García, M. A.
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Physics - Instrumentation and Detectors ,Physics - Optics - Abstract
We present here an experimental set-up to perform simultaneously measurements of surface plasmon resonance (SPR) and X-ray absorption spectroscopy (XAS) in a synchrotron beamline. The system allows measuring in situ and in real time the effect of X-ray irradiation on the SPR curves to explore the interaction of X-rays with matter. It is also possible to record XAS spectra while exciting SPR in order to detect the changes in the electronic configuration of thin films induced by the excitation of surface plasmons. Combined experiments recording simultaneously SPR and XAS curves while scanning different parameters can be carried out. The relative variations in the SPR and XAS spectra that can be detected with this set-up ranges from 10-3 to 10-5, depending on the particular experiment.
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- 2012
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29. Analysis of sustainability in a company of the oil sector in the south-marine area in the states of Tabasco and Campeche for the generation of an improvement proposal.
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De la O-Rodriguez, Karen Poulette, Morejón-Sánchez, Juana María, Eliseo-Dantés, Hortensia, and Meneses-Hernández, José Luis
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PETROLEUM industry ,CORPORATE sustainability ,ENVIRONMENTAL impact analysis ,ORGANIZATIONAL performance ,SOCIAL responsibility of business - Abstract
Copyright of Journal of Business & SMEs is the property of ECORFAN-Mexico S.C. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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30. Hacia una pedagogía solidaria en una ciudad cualquiera: ¿Quién habla? ¿Quién escucha?
- Author
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Clelia O. Rodriguez
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aprendizaje ,urbanización ,colonialismo ,violencia ,desigualdad ,Special aspects of education ,LC8-6691 ,Social sciences (General) ,H1-99 - Abstract
Este texto invita a una reflexión en torno a las siguientes preguntas: ¿Quién habla por los indígenas? ¿Quién traza los ejes urbanos? ¿Qué nos dicen las esquinas sobre historias fabricadas? ¿Has estado en una reserva indígena? ¿Un país que protege? ¿Cómo anti-discriminarme? ¿Por dónde comenzar? ¿Por la pedagogía solidaria? ¿Aprendizaje intergeneracional?
- Published
- 2019
31. Postoperative management of radical cystectomy. Review of the evidence on the prevention and treatment of urological complications
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Faba, O. Rodríguez, Moreno, R. Parada, Malca, L., Martínez, A. Palomino, Nervo, N., Breda, A., Esquinas, C., and Palou, J.
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- 2018
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32. Dislocation Emission around Nanoindentations on a (001) fcc Metal Surface Studied by STM and Atomistic Simulations
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de la Fuente, O. Rodriguez, Zimmerman, J. A., Gonzalez, M. A., de la Figuera, J., Hamilton, J. C., Pai, Woei Wu, and Rojo, J. M.
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Condensed Matter - Materials Science - Abstract
We present a combined study by Scanning Tunneling Microscopy and atomistic simulations of the emission of dissociated dislocation loops by nanoindentation on a (001) fcc surface. The latter consist of two stacking-fault ribbons bounded by Shockley partials and a stair-rod dislocation. These dissociated loops, which intersect the surface, are shown to originate from loops of interstitial character emitted along the <110> directions and are usually located at hundreds of angstroms away from the indentation point. Simulations reproduce the nucleation and glide of these dislocation loops., Comment: 10 pages, 4 figures
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- 2002
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33. SN 2016gsd: an unusually luminous and linear Type II supernova with high velocities
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T M Reynolds, M Fraser, S Mattila, M Ergon, L Dessart, P Lundqvist, Subo Dong, N Elias-Rosa, L Galbany, C P Gutiérrez, T Kangas, E Kankare, R Kotak, H Kuncarayakti, A Pastorello, O Rodriguez, S J Smartt, M Stritzinger, L Tomasella, Ping Chen, J Harmanen, G Hosseinzadeh, D Andrew Howell, C Inserra, M Nicholl, M Nielsen, K Smith, A Somero, R Tronsgaard, and D R Young
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- 2020
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34. High-Flow Oxygen Therapy Application in Chronic Obstructive Pulmonary Disease Patients With Acute Hypercapnic Respiratory Failure: A Multicenter Study
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Gustavo A. Plotnikow, RT, Matias Accoce, RT, Sebastián Fredes, RT, Norberto Tiribelli, RT, Mariano Setten, RT, Javier Dorado, RT, Maria Guaymas, MD, Santiago Ilutovich, MD, Pablo O. Rodriguez, MD, Cristian E. Cesio, MD, Jose L. Scapellato, MD, and Daniela N. Vasquez, MD
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Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Objectives:. To evaluate the effect of high-flow oxygen implementation on the respiratory rate as a first-line ventilation support in chronic obstructive pulmonary disease patients with acute hypercapnic respiratory failure. Design:. Multicenter, prospective, analytic observational case series study. Setting:. Five ICUs in Argentina, between August 2018 and September 2019. Patients:. Patients greater than or equal to 18 years old with moderate to very severe chronic obstructive pulmonary disease, who had been admitted to the ICU with a diagnosis of hypercapnic acute respiratory failure, were entered in the study. Interventions:. High-flow oxygen therapy through nasal cannula delivered using high-velocity nasal insufflation. Measurements and Main Results:. Forty patients were studied, 62.5% severe chronic obstructive pulmonary disease. After the first hour of high-flow nasal cannula implementation, there was a significant decrease of respiratory rate compared with baseline values, with a 27% decline (29 vs 21 breaths/min; p < 0.001). Furthermore, a significant reduction of Paco2 (57 vs 52 mm Hg [7.6 vs 6.9 kPa]; p < 0.001) was observed. The high-flow nasal cannula application failed in 18% patients. In this group, the respiratory rate, pH, and Paco2 showed no significant change during the first hour in these patients. Conclusions:. High-flow oxygen therapy through nasal cannula delivered using high-velocity nasal insufflation was an effective tool for reducing respiratory rate in these chronic obstructive pulmonary disease patients with acute hypercapnic respiratory failure. Early determination and subsequent monitoring of clinical and blood gas parameters may help predict the outcome.
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- 2021
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35. Comparison of performance of ADXBLADDER with urine cytology in NMIBC follow up: a blinded prospective multicentric study
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P. Gontero, F. Longo, M. Allasia, M. Roupret, J. Stockley, A. Kennedy, O. Rodriguez, C. Sieverink, F. Vanie, J. Witjes, M. Colombel, S. McCracken, T. Dudderidge, R. Sylvester, J. Palou, and E. Montanari
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Diseases of the genitourinary system. Urology ,RC870-923 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2020
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36. Partial salvage cryoablation of the prostate for local recurrent prostate cancer after primary radiotherapy: Step-by-step technique and outcomes
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R. Boissier, F. Sanguedolce, A. Territo, JM. Gaya, J. Huguet, O. Rodriguez-Faba, F. Regis, A. Gallioli, F. Vedovo, C. Martinez, J. Palou, and A. Breda
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Prostate cancer ,Biochemical recurrence ,Local recurrence ,Cryotherapy ,Focal treatment ,Surgery ,RD1-811 ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Purpose: To describe the technique as well as the oncological and functional outcomes of partial salvage prostatic cryoablation (SCAP) in the treatment of local recurrent prostate cancer after primary radiotherapy. Materials and methods: The indications for partial SCAP were: PSA10 years and PSA doubling time >12 months. Cryoablation was performed with the Precise© device (Galil MedicalⓇ, Arden Hills, Minnesota, USA). Results: Fourteen patients underwent partial SCAP from 09/2010 to 09/2018. Primary treatment consisted of: 29% brachytherapy and 71% EBRT with concomitant androgen deprivation therapy (ADT) in 50%. Median time to recurrence was 8.5 years [3.2–19.3]. At the time of cryotherapy, median age was 72 years [58–84], Charlson was 3 [1–6] and serum PSA was 4.2 [2.2–9.0]. Mean procedure time was 90 min [60–120]. Median hospital stay and catheter duration were respectively 2 days [2–6] and 8 days [3–14]. Median biochemical disease-free survival was 4.4 years and 71% of the patients were free of third-line treatment at the time of evaluation. No patient developed metastasis, and all were alive at the time of the last evaluation. De novo urinary incontinence was reported in one patient and de novo erectile dysfunction in one patient. Conclusions: Partial SCAP was an alternative to salvage prostatectomy and whole gland ablation for highly selected patients with locally recurrent PCa after radiotherapy. It significantly avoided or at least delayed the need for ADT.
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- 2020
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37. The #shitholes Syllabus: Undoing His(Story)
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Clelia O. Rodriguez
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Theory and practice of education ,LB5-3640 - Abstract
This text politicizes unlearning processes in #shitholes presented in the format of an unconventional syllabus. My proposed questions to readers in light of the Trumpism era are: How are they made? Who has created them? Do you know where they are located? If you looked at a map, can you point them out? What are they? When do they appear?
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- 2018
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38. Reduced- vs full-dose BCG in bladder cancer: A systematic review and meta-analysis
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P. Verri, M. Baboudjian, P. Diana, A. Gallioli, A. Territo, J.M. Gaya, J. Huguet, O. Rodriguez-Faba, J. Palou, and A. Breda
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General Medicine - Published
- 2023
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39. Dosis reducida vs. dosis completa de BCG en el cáncer de vejiga: revisión sistemática y metaanálisis
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P. Verri, M. Baboudjian, P. Diana, A. Gallioli, A. Territo, J.M. Gaya, J. Huguet, O. Rodriguez-Faba, J. Palou, and A. Breda
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Urology - Published
- 2023
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40. Retrotransposons Are the Major Contributors to the Expansion of the Drosophila ananassae Muller F Element
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Wilson Leung, Christopher D. Shaffer, Elizabeth J. Chen, Thomas J. Quisenberry, Kevin Ko, John M. Braverman, Thomas C. Giarla, Nathan T. Mortimer, Laura K. Reed, Sheryl T. Smith, Srebrenka Robic, Shannon R. McCartha, Danielle R. Perry, Lindsay M. Prescod, Zenyth A. Sheppard, Ken J. Saville, Allison McClish, Emily A. Morlock, Victoria R. Sochor, Brittney Stanton, Isaac C. Veysey-White, Dennis Revie, Luis A. Jimenez, Jennifer J. Palomino, Melissa D. Patao, Shane M. Patao, Edward T. Himelblau, Jaclyn D. Campbell, Alexandra L. Hertz, Maddison F. McEvilly, Allison R. Wagner, James Youngblom, Baljit Bedi, Jeffery Bettincourt, Erin Duso, Maiye Her, William Hilton, Samantha House, Masud Karimi, Kevin Kumimoto, Rebekah Lee, Darryl Lopez, George Odisho, Ricky Prasad, Holly Lyn Robbins, Tanveer Sandhu, Tracy Selfridge, Kara Tsukashima, Hani Yosif, Nighat P. Kokan, Latia Britt, Alycia Zoellner, Eric P. Spana, Ben T. Chlebina, Insun Chong, Harrison Friedman, Danny A. Mammo, Chun L. Ng, Vinayak S. Nikam, Nicholas U. Schwartz, Thomas Q. Xu, Martin G. Burg, Spencer M. Batten, Lindsay M. Corbeill, Erica Enoch, Jesse J. Ensign, Mary E. Franks, Breanna Haiker, Judith A. Ingles, Lyndsay D. Kirkland, Joshua M. Lorenz-Guertin, Jordan Matthews, Cody M. Mittig, Nicholaus Monsma, Katherine J. Olson, Guillermo Perez-Aragon, Alen Ramic, Jordan R. Ramirez, Christopher Scheiber, Patrick A. Schneider, Devon E. Schultz, Matthew Simon, Eric Spencer, Adam C. Wernette, Maxine E. Wykle, Elizabeth Zavala-Arellano, Mitchell J. McDonald, Kristine Ostby, Peter Wendland, Justin R. DiAngelo, Alexis M. Ceasrine, Amanda H. Cox, James E.B. Docherty, Robert M. Gingras, Stephanie M. Grieb, Michael J. Pavia, Casey L. Personius, Grzegorz L. Polak, Dale L. Beach, Heaven L. Cerritos, Edward A. Horansky, Karim A. Sharif, Ryan Moran, Susan Parrish, Kirsten Bickford, Jennifer Bland, Juliana Broussard, Kerry Campbell, Katelynn E. Deibel, Richard Forka, Monika C. Lemke, Marlee B. Nelson, Catherine O'Keeffe, S. Mariel Ramey, Luke Schmidt, Paola Villegas, Christopher J. Jones, Stephanie L. Christ, Sami Mamari, Adam S. Rinaldi, Ghazal Stity, Amy T. Hark, Mark Scheuerman, S. Catherine Silver Key, Briana D. McRae, Adam S. Haberman, Sam Asinof, Harriette Carrington, Kelly Drumm, Terrance Embry, Richard McGuire, Drew Miller-Foreman, Stella Rosen, Nadia Safa, Darrin Schultz, Matt Segal, Yakov Shevin, Petros Svoronos, Tam Vuong, Gary Skuse, Don W. Paetkau, Rachael K. Bridgman, Charlotte M. Brown, Alicia R. Carroll, Francesca M. Gifford, Julie Beth Gillespie, Susan E. Herman, Krystal L. Holtcamp, Misha A. Host, Gabrielle Hussey, Danielle M. Kramer, Joan Q. Lawrence, Madeline M. Martin, Ellen N. Niemiec, Ashleigh P. O'Reilly, Olivia A. Pahl, Guadalupe Quintana, Elizabeth A.S. Rettie, Torie L. Richardson, Arianne E. Rodriguez, Mona O. Rodriguez, Laura Schiraldi, Joanna J. Smith, Kelsey F. Sugrue, Lindsey J. Suriano, Kaitlyn E. Takach, Arielle M. Vasquez, Ximena Velez, Elizabeth J. Villafuerte, Laura T. Vives, Victoria R. Zellmer, Jeanette Hauke, Charles R. Hauser, Karolyn Barker, Laurie Cannon, Perouza Parsamian, Samantha Parsons, Zachariah Wichman, Christopher W. Bazinet, Diana E. Johnson, Abubakarr Bangura, Jordan A. Black, Victoria Chevee, Sarah A. Einsteen, Sarah K. Hilton, Max Kollmer, Rahul Nadendla, Joyce Stamm, Antoinette E. Fafara-Thompson, Amber M. Gygi, Emmy E. Ogawa, Matt Van Camp, Zuzana Kocsisova, Judith L. Leatherman, Cassie M. Modahl, Michael R. Rubin, Susana S. Apiz-Saab, Suzette M. Arias-Mejias, Carlos F. Carrion-Ortiz, Patricia N. Claudio-Vazquez, Debbie M. Espada-Green, Marium Feliciano-Camacho, Karina M. Gonzalez-Bonilla, Mariela Taboas-Arroyo, Dorianmarie Vargas-Franco, Raquel Montañez-Gonzalez, Joseph Perez-Otero, Myrielis Rivera-Burgos, Francisco J. Rivera-Rosario, Heather L. Eisler, Jackie Alexander, Samatha K. Begley, Deana Gabbard, Robert J. Allen, Wint Yan Aung, William D. Barshop, Amanda Boozalis, Vanessa P. Chu, Jeremy S. Davis, Ryan N. Duggal, Robert Franklin, Katherine Gavinski, Heran Gebreyesus, Henry Z. Gong, Rachel A. Greenstein, Averill D. Guo, Casey Hanson, Kaitlin E. Homa, Simon C. Hsu, Yi Huang, Lucy Huo, Sarah Jacobs, Sasha Jia, Kyle L. Jung, Sarah Wai-Chee Kong, Matthew R. Kroll, Brandon M. Lee, Paul F. Lee, Kevin M. Levine, Amy S. Li, Chengyu Liu, Max Mian Liu, Adam P. Lousararian, Peter B. Lowery, Allyson P. Mallya, Joseph E. Marcus, Patrick C. Ng, Hien P. Nguyen, Ruchik Patel, Hashini Precht, Suchita Rastogi, Jonathan M. Sarezky, Adam Schefkind, Michael B. Schultz, Delia Shen, Tara Skorupa, Nicholas C. Spies, Gabriel Stancu, Hiu Man Vivian Tsang, Alice L. Turski, Rohit Venkat, Leah E. Waldman, Kaidi Wang, Tracy Wang, Jeffrey W. Wei, Dennis Y. Wu, David D. Xiong, Jack Yu, Karen Zhou, Gerard P. McNeil, Robert W. Fernandez, Patrick Gomez Menzies, Tingting Gu, Jeremy Buhler, Elaine R. Mardis, and Sarah C.R. Elgin
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Drosophila ,genome size ,heterochromatin ,retrotransposons ,Wolbachia ,Genetics ,QH426-470 - Abstract
The discordance between genome size and the complexity of eukaryotes can partly be attributed to differences in repeat density. The Muller F element (∼5.2 Mb) is the smallest chromosome in Drosophila melanogaster, but it is substantially larger (>18.7 Mb) in D. ananassae. To identify the major contributors to the expansion of the F element and to assess their impact, we improved the genome sequence and annotated the genes in a 1.4-Mb region of the D. ananassae F element, and a 1.7-Mb region from the D element for comparison. We find that transposons (particularly LTR and LINE retrotransposons) are major contributors to this expansion (78.6%), while Wolbachia sequences integrated into the D. ananassae genome are minor contributors (0.02%). Both D. melanogaster and D. ananassae F-element genes exhibit distinct characteristics compared to D-element genes (e.g., larger coding spans, larger introns, more coding exons, and lower codon bias), but these differences are exaggerated in D. ananassae. Compared to D. melanogaster, the codon bias observed in D. ananassae F-element genes can primarily be attributed to mutational biases instead of selection. The 5′ ends of F-element genes in both species are enriched in dimethylation of lysine 4 on histone 3 (H3K4me2), while the coding spans are enriched in H3K9me2. Despite differences in repeat density and gene characteristics, D. ananassae F-element genes show a similar range of expression levels compared to genes in euchromatic domains. This study improves our understanding of how transposons can affect genome size and how genes can function within highly repetitive domains.
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- 2017
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41. Impacts of seasonality and parasitism on honey bee population dynamics
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Chen, Jun, primary, Rincon, Jordy O. Rodriguez, additional, DeGrandi-Hoffman, Gloria, additional, Fewell, Jennifer, additional, Harrison, Jon, additional, and Kang, Yun, additional
- Published
- 2023
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- View/download PDF
42. Experimental Assessment of Axillary Lymph Node Microwave Tomography Using Anthropomorphic Phantoms
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Savazzi, Matteo, primary, Karadima, Olympia, additional, Duarte, David O. Rodriguez, additional, Tobon Vasquez, Jorge, additional, Vipiana, Francesca, additional, Kosmas, Panagiotis, additional, Fernandes, Carlos A., additional, Felício, João M., additional, and Conceição, Raquel C., additional
- Published
- 2023
- Full Text
- View/download PDF
43. Experimental Validation of a Microwave System for Brain Stroke 3-D Imaging
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David O. Rodriguez-Duarte, Jorge A. Tobon Vasquez, Rosa Scapaticci, Giovanna Turvani, Marta Cavagnaro, Mario R. Casu, Lorenzo Crocco, and Francesca Vipiana
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microwave imaging ,biomedical imaging ,brain stroke monitoring ,antenna array ,hemorrhagic stroke ,ischemic stroke ,Medicine (General) ,R5-920 - Abstract
This paper experimentally validates the capability of a microwave prototype device to localize hemorrhages and ischemias within the brain as well as proposes an innovative calibration technique based on the measured data. In the reported experiments, a 3-D human-like head phantom is considered, where the brain is represented either with a homogeneous liquid mimicking brain dielectric properties or with ex vivo calf brains. The microwave imaging (MWI) system works at 1 GHz, and it is realized with a low-complexity architecture formed by an array of twenty-four printed monopole antennas. Each antenna is embedded into the “brick” of a semi-flexible dielectric matching medium, and it is positioned conformal to the head upper part. The imaging algorithm exploits a differential approach and provides 3-D images of the brain region. It employs the singular value decomposition of the discretized scattering operator obtained via accurate numerical models. The MWI system analysis shows promising reconstruction results and extends the device validation.
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- 2021
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44. Influence of single point incremental forming on the quality and surface properties of parts manufactured with aluminized steel sheets pre-coated with PTFE
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O. Rodriguez-Alabanda and G. Guerrero-Vaca
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Industrial and Manufacturing Engineering - Published
- 2022
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45. Calculating structural and geometrical parameters by laboratory measurements and X-ray microtomography: a comparative study applied to a limestone sample before and after a dissolution experiment
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L. Luquot, V. Hebert, and O. Rodriguez
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Geology ,QE1-996.5 ,Stratigraphy ,QE640-699 - Abstract
The aim of this study is to compare the structural, geometrical and transport parameters of a limestone rock sample determined by X-ray microtomography (XMT) images and laboratory experiments. Total and effective porosity, pore-size distribution, tortuosity, and effective diffusion coefficient have been estimated. Sensitivity analyses of the segmentation parameters have been performed. The limestone rock sample studied here has been characterized using both approaches before and after a reactive percolation experiment. Strong dissolution process occurred during the percolation, promoting a wormhole formation. This strong heterogeneity formed after the percolation step allows us to apply our methodology to two different samples and enhance the use of experimental techniques or XMT images depending on the rock heterogeneity. We established that for most of the parameters calculated here, the values obtained by computing XMT images are in agreement with the classical laboratory measurements. We demonstrated that the computational porosity is more informative than the laboratory measurement. We observed that pore-size distributions obtained by XMT images and laboratory experiments are slightly different but complementary. Regarding the effective diffusion coefficient, we concluded that both approaches are valuable and give similar results. Nevertheless, we concluded that computing XMT images to determine transport, geometrical, and petrophysical parameters provide similar results to those measured at the laboratory but with much shorter durations.
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- 2016
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46. Anatomy of the isthmus: unraveling tissue composition of ventricular tachycardia diastolic pathway
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F Bisbal, J Aranyo, D Sanchez-Quintana, D Martinez-Falguera, O Rodriguez-Leor, E Fadeuihle, V Bazan, A Sarrias, R Villuendas, A Bayes-Genis, and C Galvez-Monton
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Abstract
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Spanish Ministry of Science and Innovation Background Unequal tissue composition of post-myocardial infarction (MI) scar (viable myocardium, fibrosis, fatty infiltration) leads to heterogeneous conduction properties and excitability. The presence of a protected diastolic, slow-conducting pathway (isthmus) is the electrophysiological landmark of post-MI reentrant ventricular tachycardia (VT). Contemporary histological studies evaluating the tissue features needed for slow, protected conduction during VT are lacking. Purpose To characterize tissue composition singularities of confirmed VT isthmuses (VTI) in a chronic MI swine model, and to compare it to non-isthmus scar (NIS). Methods One-month after a non-reperfused anterior MI, 9 Landrace X Large White pigs (4 female; 33.6±2.2 Kg) with inducible VT underwent high-density activation mapping to define the diastolic corridor. VTI was defined as part of the diastolic pathway exhibiting mid-diastolic potentials. Discrete radiofrequency applications were delivered in the vicinity of the VTI and used as tissue landmarks to guide the ex vivo isthmus localization. Tissue transverse samples (5 mm) from the labelled VTI and NIS were obtained for further histological and immunohistochemical analysis. Dense scar and border zones were analyzed. Results Compared to NIS, border zone of VTI showed significantly higher fatty infiltration (p=0.016) and dense scar displayed less Collagen I (p=0.053), Collagen III (p=0.043), and Collagen Volume Fraction (p=0.027), without differences in the overall fibrotic deposition (P=0.119). Immunohistochemical studies revealed greater vascular density (Isolectin B4-positive vessels) at VTI, compared to NIS (p=0.018). Arteries and veins at the VTI were mostly surrounded by preserved cardiomyocytes (figure 1). Viable cardiomyocytes and fibroblasts at VTI displayed higher density of Cx43 and Cx40, respectively, compared to those at NIS (p=0.022 and p=0.004, respectively), despite no differences in cTnI, SERCA2 and Vimentin expression (figure 2). Conclusion The VTI exhibits distinctive tissue features compared to NIS. Unique electrophysiological properties of the VTI may be driven by increased adipocytic deposition, vascular density and Cx43/Cx40 expression, as well as lower presence of Collagen III and Collagen Volume Fraction.
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- 2023
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47. Physiological stimulation in preserved ejection fraction: A randomized trial
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O Rodriguez Queralto, C Gonzalez Matos, F Zaraket, J Jimenez Lopez, B Casteigt, C Rodriguez Gonzalez, and E Valles Gras
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Abstract
Funding Acknowledgements Type of funding sources: None. Introduction Right ventricular stimulation in the apex (RVAS) produce dysynchrony, leading to left ventricle systolic dysfunction (LVSD) in some cases. Circumstances that can worsen the LVSD are a high burden of RVAS, and the presence of previous LVSD and/or intraventricular conduction disease (IVCD). Direct activation of the specialized conduction system with physiological stimulation (PS) can preserve this physiological pattern and shorten de QRS when the impairment is proximal to the pacing site. Most of the studies with PS has been focused on patients with LVSD, with few and scarce evidences regarding pacients without LVSD. Objectives and methods This is a parallel, single blinded, unicentric, randomized trial of patients with preserved of mild reduced left ventricular ejection fraction (LVEF) submitted to a pacemaker implantation due to atrioventricular block (AVB), with previous IVCD (wide QRS) an anticipated high rate of ventricular pacing. Patients were randomized 1:1 to RVAS vs PS and followed for 6 months. Clinical, ECG, echocardiography and analytic parameters were compared. The primary endpoint was the change in the LVEF at 6 months in each group. The secondary endpoints were the changes in the left ventricular end-diastolic diameter (LVEDD), the QRS duration, the pro–B-type natriuretic peptide (NT-proBNP), the NYHA class, and the Minnesota Living with Heart Failure Questionnaire (MLWHFQ) in each group. Results The study included 57 patients of 77±9,6 years. Of all patients, 53% were treated with RVAS and 47% with PS. There were 2 patients with crossover to RVAS for technical difficulties and 1 patient with crossover to PS due to apical scar. There were no differences in the basal QRS duration (142.08±20,2 ms), LVEF (58.87±7,2%), NT-proBNP (3336,03±7258,68 pg/ml), or MLWHFQ (22,19±14,68), between both groups (Table 1). Acutely significant differences were observed in the change of QRS duration among groups (+16±29 ms in the RVAS group vs -17±25 ms in the PS group, p Conclusions In patients with preserved LVEF requiring pacemaker implantation for AVB, PS shorten the QTS duration and preserves the LVEF compared to RVAS.
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- 2023
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48. Impact of Automated Drainage on Suction Pressure During Thoracentesis: An In-vitro and In-vivo Analysis
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A.A. Menon, O. Rodriguez, N. Belkhayat, V.E. Forth, A. Ramaswamy, and M. Shafiq
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- 2023
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49. Supplementary Figures S1-S4 from Establishment of a Dog Model for the p53 Family Pathway and Identification of a Novel Isoform of p21 Cyclin-Dependent Kinase Inhibitor
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Xinbin Chen, Carlos O. Rodriguez, Michael S. Kent, Xiangling Chen, and Jin Zhang
- Abstract
Supplementary Figures S1-S4 from Establishment of a Dog Model for the p53 Family Pathway and Identification of a Novel Isoform of p21 Cyclin-Dependent Kinase Inhibitor
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- 2023
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50. Data from Establishment of a Dog Model for the p53 Family Pathway and Identification of a Novel Isoform of p21 Cyclin-Dependent Kinase Inhibitor
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Xinbin Chen, Carlos O. Rodriguez, Michael S. Kent, Xiangling Chen, and Jin Zhang
- Abstract
Spontaneous tumors in the dog offer a unique opportunity as models to study human cancer etiology and therapy. p53, the most commonly mutated gene in human cancers, is found to be altered in dog cancers. However, little is known about the role of p53 in dog tumorigenesis. Here, we found that on exposure to DNA damage agents or MDM2 inhibitor nutlin-3, canine p53 is accumulated and capable of inducing its target genes, MDM2 and p21. We also found that on DNA damage, canine p53 is accumulated in the nucleus, followed by MDM2 nuclear translocation and increased 53BP1 foci formation. In addition, we found that canine p63 and p73 are up-regulated by DNA damage agents. Furthermore, colony formation assay showed that canine tumor cells are sensitive to DNA damage agents and nutlin-3 in a p53-dependent manner. Surprisingly, canine p21 is expressed as two isoforms. Thus, we generated multiple canine p21 mutants and found that amino acids 129 to 142 are required, whereas amino acid 139 is one of the key determinants, for the expression of two p21 isoforms. Finally, we showed that although the full-length human p21 cDNA expresses one polypeptide, amino acid 139 seems to play a similar role as that in canine p21 for various migration patterns. Taken together, our results indicate that canine p53 family proteins have biological activities similar to human counterparts. These similarities make the dog an excellent outbred spontaneous tumor model, and the dog can serve as a translation model from benchtop to cage side and then to bedside. (Mol Cancer Res 2009;7(1):67–78)
- Published
- 2023
- Full Text
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