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2. Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan

Author

Vandenput, L., Johansson, H., McCloskey, E. V., Liu, E., Åkesson, K. E., Anderson, F. A., Azagra, R., Bager, C. L., Beaudart, C., Bischoff-Ferrari, H. A., Biver, E., Bruyère, O., Cauley, J. A., Center, J. R., Chapurlat, R., Christiansen, C., Cooper, C., Crandall, C. J., Cummings, S. R., da Silva, J. A. P., Dawson-Hughes, B., Diez-Perez, A., Dufour, A. B., Eisman, J. A., Elders, P. J. M., Ferrari, S., Fujita, Y., Fujiwara, S., Glüer, C.-C., Goldshtein, I., Goltzman, D., Gudnason, V., Hall, J., Hans, D., Hoff, M., Hollick, R. J., Huisman, M., Iki, M., Ish-Shalom, S., Jones, G., Karlsson, M. K., Khosla, S., Kiel, D. P., Koh, W.-P., Koromani, F., Kotowicz, M. A., Kröger, H., Kwok, T., Lamy, O., Langhammer, A., Larijani, B., Lippuner, K., Mellström, D., Merlijn, T., Nordström, A., Nordström, P., O’Neill, T. W., Obermayer-Pietsch, B., Ohlsson, C., Orwoll, E. S., Pasco, J. A., Rivadeneira, F., Schei, B., Schott, A.-M., Shiroma, E. J., Siggeirsdottir, K., Simonsick, E. M., Sornay-Rendu, E., Sund, R., Swart, K. M. A., Szulc, P., Tamaki, J., Torgerson, D. J., van Schoor, N. M., van Staa, T. P., Vila, J., Wareham, N. J., Wright, N. C., Yoshimura, N., Zillikens, M. C., Zwart, M., Harvey, N. C., Lorentzon, M., Leslie, W. D., and Kanis, J. A.

Published
2022
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5. A meta-analysis of previous falls and subsequent fracture risk in cohort studies

Author

Vandenput, L., Johansson, H., McCloskey, E. V., Liu, E., Schini, M., Åkesson, K.E., Anderson, F. A., Azagra, R., Bager, C. L., Beaudart, C., Bischoff-Ferrari, H. A., Biver, E., Bruyère, O., Cauley, J. A., Center, J. R., Chapurlat, R., Christiansen, C., Cooper, C., Crandall, C. J., Cummings, S. R., da Silva, J. A. P., Dawson-Hughes, B., Diez-Perez, A., Dufour, A. B., Eisman, J. A., Elders, P. J. M., Ferrari, S., Fujita, Y., Fujiwara, S., Glüer, C. -C, Goldshtein, I., Goltzman, D., Gudnason, V., Hall, J., Hans, D., Hoff, M., Hollick, R. J., Huisman, M., Iki, M., Ish-Shalom, S., Jones, G., Karlsson, M. K., Khosla, S., Kiel, D. P., Koh, W. -P, Koromani, F., Kotowicz, M. A., Kröger, H., Kwok, T., Lamy, O., Langhammer, A., Larijani, B., Lippuner, K., McGuigan, F. E. A., Mellström, D., Merlijn, T., Nguyen, T. V., Nordström, Anna, Nordström, P., O’Neill, T. W., Obermayer-Pietsch, B., Ohlsson, C., Orwoll, E. S., Pasco, J. A., Rivadeneira, F., Schott, A. -M, Shiroma, E. J., Siggeirsdottir, K., Simonsick, E. M., Sornay-Rendu, E., Sund, R., Swart, K. M. A., Szulc, P., Tamaki, J., Torgerson, D. J., van Schoor, N. M., van Staa, T. P., Vila, J., Wareham, N. J., Wright, N. C., Yoshimura, N., Zillikens, M. C., Zwart, M., Harvey, N. C., Lorentzon, M., Leslie, W. D., Kanis, J. A., Vandenput, L., Johansson, H., McCloskey, E. V., Liu, E., Schini, M., Åkesson, K.E., Anderson, F. A., Azagra, R., Bager, C. L., Beaudart, C., Bischoff-Ferrari, H. A., Biver, E., Bruyère, O., Cauley, J. A., Center, J. R., Chapurlat, R., Christiansen, C., Cooper, C., Crandall, C. J., Cummings, S. R., da Silva, J. A. P., Dawson-Hughes, B., Diez-Perez, A., Dufour, A. B., Eisman, J. A., Elders, P. J. M., Ferrari, S., Fujita, Y., Fujiwara, S., Glüer, C. -C, Goldshtein, I., Goltzman, D., Gudnason, V., Hall, J., Hans, D., Hoff, M., Hollick, R. J., Huisman, M., Iki, M., Ish-Shalom, S., Jones, G., Karlsson, M. K., Khosla, S., Kiel, D. P., Koh, W. -P, Koromani, F., Kotowicz, M. A., Kröger, H., Kwok, T., Lamy, O., Langhammer, A., Larijani, B., Lippuner, K., McGuigan, F. E. A., Mellström, D., Merlijn, T., Nguyen, T. V., Nordström, Anna, Nordström, P., O’Neill, T. W., Obermayer-Pietsch, B., Ohlsson, C., Orwoll, E. S., Pasco, J. A., Rivadeneira, F., Schott, A. -M, Shiroma, E. J., Siggeirsdottir, K., Simonsick, E. M., Sornay-Rendu, E., Sund, R., Swart, K. M. A., Szulc, P., Tamaki, J., Torgerson, D. J., van Schoor, N. M., van Staa, T. P., Vila, J., Wareham, N. J., Wright, N. C., Yoshimura, N., Zillikens, M. C., Zwart, M., Harvey, N. C., Lorentzon, M., Leslie, W. D., and Kanis, J. A.

Abstract

Summary: The relationship between self-reported falls and fracture risk was estimated in an international meta-analysis of individual-level data from 46 prospective cohorts. Previous falls were associated with an increased fracture risk in women and men and should be considered as an additional risk factor in the FRAX® algorithm. Introduction: Previous falls are a well-documented risk factor for subsequent fracture but have not yet been incorporated into the FRAX algorithm. The aim of this study was to evaluate, in an international meta-analysis, the association between previous falls and subsequent fracture risk and its relation to sex, age, duration of follow-up, and bone mineral density (BMD). Methods: The resource comprised 906,359 women and men (66.9% female) from 46 prospective cohorts. Previous falls were uniformly defined as any fall occurring during the previous year in 43 cohorts; the remaining three cohorts had a different question construct. The association between previous falls and fracture risk (any clinical fracture, osteoporotic fracture, major osteoporotic fracture, and hip fracture) was examined using an extension of the Poisson regression model in each cohort and each sex, followed by random-effects meta-analyses of the weighted beta coefficients. Results: Falls in the past year were reported in 21.4% of individuals. During a follow-up of 9,102,207 person-years, 87,352 fractures occurred of which 19,509 were hip fractures. A previous fall was associated with a significantly increased risk of any clinical fracture both in women (hazard ratio (HR) 1.42, 95% confidence interval (CI) 1.33–1.51) and men (HR 1.53, 95% CI 1.41–1.67). The HRs were of similar magnitude for osteoporotic, major osteoporotic fracture, and hip fracture. Sex significantly modified the association between previous fall and fracture risk, with predictive values being higher in men than in women (e.g., for major osteoporotic fracture, HR 1.53 (95% CI 1.27–1.84) in men vs. HR 1.32

Published
2024
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6. An efficient tool to find multispecies MSY for interacting fish stocks.

Author

Del Santo O'Neill, T. J., Rossberg, A. G., and Thorpe, R. B.

Subjects
*FISH populations, *FISHERY management, *OPTIMIZATION algorithms, *BIOTIC communities
Abstract

Natural ecological communities exhibit complex mixtures of interspecific biological interactions, which makes finding optimal yet sustainable exploitation rates challenging. Most fisheries management advice is at present based on applying the Maximum Sustainable Yield (MSY) target to each species in a community by modelling it as if it was a monoculture. Such application of single‐species MSY policies to strongly interacting populations can result in tragic overexploitation. However, the idea of 'maximising the yield from each species separately' can be extended to take into account species interactions. This leads to a form of Nash Equilibrium, where the yields of each species are simultaneously maximised. Here we present 'nash', an R package that streamlines the computation of Nash equilibrium reference points for fisheries and other systems represented by a user‐defined multispecies or ecosystem model. We present two real‐world fisheries management applications alongside performance benchmarks. Satisfactory search results are shown across models with an approximate factor 7 increase in performance when compared to the expensive round‐robbing sequential optimisation algorithms used by other authors in the literature. We believe that the nash package can play an instrumental role in fully implementing ecosystem‐based management policies worldwide. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Desiring a career in STEM-related fields: How middle school girls articulate and negotiate identities-in-practice in science

Author

Tan, E, Calabrese Barton, A, Kang, H, and O'Neill, T

Subjects
Pediatric, Stem Cell Research, Education, Curriculum and Pedagogy, Specialist Studies in Education
Abstract

The underrepresentation of non-White students and girls in STEM fields is an ongoing problem that is well documented. In K-12 science education, girls, and especially non-White girls, often do not identify with science regardless of test scores. In this study, we examine the narrated and embodied identities-in-practice of non-White, middle school girls who articulate future career goals in STEM-related fields. For these girls who desire an STEM-related career, we examine the relationships between their narrated and embodied identities-in-practice. Drawing on interview and ethnographic data in both school and after school science contexts, we examine how STEM-career minded middle school girls articulate and negotiate a path for themselves through their narratives and actions. We present four types of relationships between girls' narrated and embodied identities-in-practice, each with a representative case study: (1) partial overlaps, (2) significant overlaps, (3) contrasting, and (4) transformative. The implications of these relationships with regard to both hurdles and support structures that are needed to equip and empower girls in pursuit of their STEM trajectories are discussed. © 2013 Wiley Periodicals, Inc. J Res Sci Teach 50: 1143-1179, 2013.

Published
2013

11. Measurement of R = sigma_L / sigma_T and the Separated Longitudinal and Transverse Structure Functions in the Nucleon Resonance Region

Author

Collaboration, The Jefferson Lab Hall C E94-110, Liang, Y., Tvaskis, V., Christy, M. E., Ahmidouch, A., Armstrong, C. S., Arrington, J., Asaturyan, R., Avery, S., Baker, O. K., Beck, D. H., Blok, H. P., Bochna, C. W., Boeglin, W., Bosted, P., Bouwhuis, M., Breuer, H., Brown, D. S., Bruell, A., Carlini, R. D., Cha, J., Chant, N. S., Cochran, A., Cole, L., Danagoulian, S., Day, D. B., Dunne, J., Dutta, D., Ent, R., Fenker, H. C., Fox, B., Gan, L., Gao, H., Garrow, K., Gaskell, D., Gasparian, A., Geesaman, D. F., Gilman, R., Gu`eye, P. L. J., Harvey, M., Holt, R. J., Jiang, X., Jones, M., Keppel, C. E., Kinney, E., Lorenzon, W., Lung, A., Mack, D. J., Markowitz, P., Martin, J. W., McIlhany, K., McKee, D., Meekins, D., Miller, M. A., Milner, R. G., Mitchell, J. H., Mkrtchyan, H., Mueller, B. A., Nathan, A., Niculescu, G., Niculescu, I., O'Neill, T. G., Papavassiliou, V., Pate, S. F., Piercey, R. B., Potterveld, D., Ransome, R. D., Reinhold, J., Rollinde, E., Rondon, O., Roos, P., Sarty, A. J., Sawafta, R., Schulte, E. C., Segbefia, E., Smith, C., Stepanyan, S., Strauch, S., Tadevosyan, V., Tang, L., Tieulent, R., Uzzle, A., Vulcan, W. F., Wood, S. A., Xiong, F., Yuan, L., Zeier, M., Zihlmann, B., and Ziskin, V.

Subjects
Nuclear Experiment
Abstract

We report on a detailed study of longitudinal strength in the nucleon resonance region, presenting new results from inclusive electron-proton cross sections measured at Jefferson Lab Hall C in the four-momentum transfer range 0.2 < Q^2 < 5.5 GeV^2. The data have been used to accurately perform 167 Rosenbluth-type longitudinal / transverse separations. The precision R = sigma_L / sigma_T data are presented here, along with the first separate values of the inelastic structure functions F_1 and F_L in this regime. The resonance longitudinal component is found to be significant, both in magnitude and in the existence of defined mass peaks. Additionally, quark-hadron duality is here observed above Q^2 = 1 GeV^2 in the separated structure functions independently., Comment: 5 pages, 4 figures

Published
2004

12. Dialectical and trinitarian structure of Paul Tillich's systematic theology, with reference to G.W.F. Hegel and F.W.J. Schelling

Author

O'Neill, T. Andrew J.

Subjects
270.092
Abstract

This thesis makes a clear distinction between the relative influence of Hegel and Schelling on Tillich’s Systematic Theology, by focusing on the concepts of dialectic and the Trinity. It begins by calling into question the appropriateness of the method of correlation as a description of the structure of the Systematic Theology. It subsequently demonstrates that two different kinds of dialectic provide the actual structure of the Systematic Theology: a polar form of dialectic, which can be attributed to the influence of F. W. J. Schelling, predominant in the first volume of Tillich’s system; and a triadic form, attributable to G. W. F. Hegel, which provides the structure for all three volumes of Tillich’s system. Finally, it demonstrates the Hegelian influence on Tillich’s concept of the Trinity. This investigation is unique in three ways: in its argument that the method of correlation is not commensurate with what Tillich intends for the Systematic Theology; in its consideration of the Systematic Theology as a whole; and in its consultation of recent translations of the works of Hegel and Schelling, and recent English-speaking research into German Idealism.

Published
2007

14. POS0526 PAIN PROCESSING IS ALTERED ABOVE PAGETIC BONE

Author

Berg, K., primary, Dockrell, D., additional, Aspray, T., additional, Colvin, L., additional, Dennison, E., additional, Divyateja, H., additional, Ghouri, N., additional, Keen, R., additional, O’neill, T., additional, Rahman, F., additional, Siddiqi, M., additional, Tuck, S., additional, Turton, J., additional, and Ralston, S., additional

Published
2023
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17. Phoma basal rot of Romaine lettuce in California caused by Phoma exigua: Occurrence, characterization, and control

Author

Koike, S T, Subbarao, K V, Verkley, GJM, Fogle, D, and O'Neill, T M

Abstract

Beginning in 2000 and continuing into 2004, a previously undescribed disease caused significant damage to romaine lettuce (Lactuca sativa) in the coastal Salinas Valley of California. Symptoms were brownish black, sunken cavities on the crown and upper taproot. Cavities were firm, lacked signs of fungal growth, and resulted in cracking and weakening of the crown. Affected plants were stunted, uneven in growth, and unmarketable. Crisphead lettuce also developed these symptoms, although disease incidence was always lower than that for romaine. A fungus was consistently isolated from cavities. Using morphological features and molecular methods, the fungus was identified as Phoma exigua. Pathogenicity of isolates from romaine and crisphead lettuce was demonstrated on both of these lettuce types. Replicated field studies showed that azoxystrobin, boscalid, and cyprodinil + fludioxonil fungicides effectively controlled the disease. This is the first report of a crown disease caused by P. exigua in the United States. A similar disease, Phoma basal rot on greenhouse grown lettuce in the United Kingdom, had been previously observed, but no report has been published.

Published
2006

18. Inclusive Electron Scattering from Nuclei at $x \simeq 1$

Author

Arrington, J., Anthony, P., Arnold, R. G., Beise, E. J., Belz, J. E., Bosted, P. E., Bulten, H. -J., Chapman, M. S., Coulter, K. P., Dietrich, F., Ent, R., Epstein, M., Filippone, B. W., Gao, H., Gearhart, R. A., Geesaman, D. F., Hansen, J. -O., Holt, R. J., Jackson, H. E., Jones, C. E., Keppel, C. E., Kinney, E. R., Kuhn, S., Lee, K., Lorenzon, W., Lung, A., Makins, N. C. R., Margaziotis, D. J., McKeown, R. D., Milner, R. G., Mueller, B., Napolitano, J., Nelson, J., O'Neill, T. G., Papavassiliou, V., Petratos, G. G., Potterveld, D. H., Rock, S. E., Spengos, M., Szalata, Z. M., Tao, L. H., vanBibber, K., Brand, J. F. J. van den, White, J. L., Winter, D., and Zeidman, B.

Subjects
Nuclear Experiment
Abstract

The inclusive A(e,e') cross section for $x \simeq 1$ was measured on $^2$H, C, Fe, and Au for momentum transfers $Q^2$ from 1-7 (GeV/c)$^2$. The scaling behavior of the data was examined in the region of transition from y-scaling to x-scaling. Throughout this transitional region, the data exhibit $\xi$-scaling, reminiscent of the Bloom-Gilman duality seen in free nucleon scattering., Comment: 4 pages, RevTeX; 4 figures (postscript in .tar.Z file)

Published
1995
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19. A-dependence of nuclear transparency in quasielastic A(e,e'p) at high Q^2

Author

O'Neill, T. G.

Subjects
High Energy Physics - Phenomenology
Abstract

The A-dependence of the quasielastic A(e,e'p) reaction has been studied at SLAC with H-2, C, Fe, and Au nuclei at momentum transfers Q^2 = 1, 3, 5, and 6.8 (GeV/c)^2. We extract the nuclear transparency T(A,Q^2), a measure of the average probability that the struck proton escapes from the nucleus A without interaction. Several calculations predict a significant increase in T with momentum transfer, a phenomenon known as Color Transparency. No significant rise within errors is seen for any of the nuclei studied., Comment: 5 pages incl. 2 figures, Caltech preprint OAP-731

Published
1994
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20. Prototype TIGRE compton gamma-ray balloon-borne telescope

Author

Bhattacharya, D, O'Neill, T J, Akyuz, A, Samimi, J, and Zych, A D

Subjects
gamma-ray astronomy, Compton telescope, electron tracking
Abstract

A prototype balloon-borne telescope is being constructed for gamma-ray observations in the MeV energy range. The Tracking and Imaging Gamma-Ray Experiment (TIGRE) uses multi-layers of thin silicon detectors to track and measure the energy losses of Compton recoil electrons. When combined with the direction and energy of the Compton scattered gamma-ray a unique incident direction for each photon event is determined. This facilitates background rejection, improved sensitivity and image reconstruction. The converter/tracker also serves as an electron-positron pair detector for gamma-rays up to 100 MeV. The initial continental US flight will be used to determine the sub-orbital atmospheric backgrounds and search for polarized gamma-emission for the Crab pulsar. Longer southern hemisphere flights with an enhanced instrument will map out the Al-26 emissions from the galactic center region. (C) 2003 Elsevier B.V. All rights reserved.

Published
2004

22. Measurement of R=σL/σT and the separated longitudinal and transverse structure functions in the nucleon-resonance region

Author

Liang, Y., Tvaskis, V., Christy, M. E., Ahmidouch, A., Armstrong, C. S., Arrington, J., Asaturyan, R., Avery, S., Baker, O. K., Beck, D. H., Blok, H. P., Bochna, C. W., Boeglin, W., Bosted, P., Bouwhuis, M., Breuer, H., Brown, D. S., Bruell, A., Carlini, R. D., Cha, J., Chant, N. S., Cochran, A., Cole, L., Danagoulian, S., Day, D. B., Dunne, J., Dutta, D., Ent, R., Fenker, H. C., Fox, B., Gan, L., Gao, H., Garrow, K., Gaskell, D., Gasparian, A., Geesaman, D. F., Gilman, R., Guèye, P. L.J., Harvey, M., Holt, R. J., Jiang, X., Jones, M., Keppel, C. E., Kinney, E., Lorenzon, W., Lung, A., Mack, D. J., Markowitz, P., Martin, J. W., Mcilhany, K., Mckee, D., Meekins, D., Miller, M. A., Milner, R. G., Mitchell, J. H., Mkrtchyan, H., Mueller, B. A., Nathan, A., Niculescu, G., Niculescu, I., O'neill, T. G., Papavassiliou, V., Pate, S. F., Piercey, R. B., Potterveld, D., Ransome, R. D., Reinhold, J., Rollinde, E., Rondon, O., Roos, P., Sarty, A. J., Sawafta, R., Schulte, E. C., Segbefia, E., Smith, C., Stepanyan, S., Strauch, S., Tadevosyan, V., Tang, L., Tieulent, R., Uzzle, A., Vulcan, W. F., Wood, S. A., Xiong, F., Yuan, L., Zeier, M., Zihlmann, B., Ziskin, V., and Student Lab and Education

Subjects
Particle and Plasma Physics, Molecular, Nuclear, Atomic, Nuclear & Particles Physics
Abstract

We report on a detailed study of longitudinal strength in the nucleon resonance region, presenting new results from inclusive electron-proton cross sections measured at Jefferson Lab Hall C in the four-momentum transfer range 0.2

Published
2022

26. Lower bone turnover and relative bone deficits in men with metabolic syndrome: a matter of insulin sensitivity? The European Male Ageing Study

Author

Laurent, M. R., Cook, M. J., Gielen, E., Ward, K. A., Antonio, L., Adams, J. E., Decallonne, B., Bartfai, G., Casanueva, F. F., Forti, G., Giwercman, A., Huhtaniemi, I. T., Kula, K., Lean, M. E. J., Lee, D. M., Pendleton, N., Punab, M., Claessens, F., Wu, F. C. W., Vanderschueren, D., Pye, S. R., O’Neill, T. W., and EMAS Group

Published
2016
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27. Update of the fracture risk prediction tool FRAX:a systematic review of potential cohorts and analysis plan

Author

Vandenput, L, Johansson, H, McCloskey, E V, Liu, E, Åkesson, K E, Anderson, F A, Azagra, R, Bager, C L, Beaudart, C, Bischoff-Ferrari, H A, Biver, E, Bruyère, O, Cauley, J A, Center, J R, Chapurlat, R, Christiansen, C, Cooper, C, Crandall, C J, Cummings, S R, da Silva, J A P, Dawson-Hughes, B, Diez-Perez, A, Dufour, A B, Eisman, J A, Elders, P J M, Ferrari, S, Fujita, Y, Fujiwara, S, Glüer, C-C, Goldshtein, I, Goltzman, D, Gudnason, V, Hall, J, Hans, D, Hoff, M, Hollick, R J, Huisman, M, Iki, M, Ish-Shalom, S, Jones, G, Karlsson, M K, Khosla, S, Kiel, D P, Koh, W-P, Koromani, F, Kotowicz, M A, Kröger, H, Kwok, T, Lamy, O, Langhammer, A, Larijani, B, Lippuner, K, Mellström, D, Merlijn, T, Nordström, A, Nordström, P, O'Neill, T W, Obermayer-Pietsch, B, Ohlsson, C, Orwoll, E S, Pasco, J A, Rivadeneira, F, Schei, B, Schott, A-M, Shiroma, E J, Siggeirsdottir, K, Simonsick, E M, Sornay-Rendu, E, Sund, R, Swart, K M A, Szulc, P, Tamaki, J, Torgerson, D J, van Schoor, N M, van Staa, T P, Vila, J, Wareham, N J, Wright, N C, Yoshimura, N, Zillikens, M C, Zwart, M, Harvey, N C, Lorentzon, M, Leslie, W D, and Kanis, J A

Subjects
SDG 3 - Good Health and Well-being, Bone Density, Hip Fractures, Risk Factors, Endocrinology, Diabetes and Metabolism, Humans, Osteoporosis, Prospective Studies, 610 Medicine & health, Risk Assessment, Osteoporotic Fractures
Abstract

We describe the collection of cohorts together with the analysis plan for an update of the fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource comprises 2,138,428 participants with a follow-up of approximately 20 million person-years and 116,117 documented incident major osteoporotic fractures. INTRODUCTION The availability of the fracture risk assessment tool FRAX® has substantially enhanced the targeting of treatment to those at high risk of fracture with FRAX now incorporated into more than 100 clinical osteoporosis guidelines worldwide. The aim of this study is to determine whether the current algorithms can be further optimised with respect to current and novel risk factors. METHODS A computerised literature search was performed in PubMed from inception until May 17, 2019, to identify eligible cohorts for updating the FRAX coefficients. Additionally, we searched the abstracts of conference proceedings of the American Society for Bone and Mineral Research, European Calcified Tissue Society and World Congress of Osteoporosis. Prospective cohort studies with data on baseline clinical risk factors and incident fractures were eligible. RESULTS Of the 836 records retrieved, 53 were selected for full-text assessment after screening on title and abstract. Twelve cohorts were deemed eligible and of these, 4 novel cohorts were identified. These cohorts, together with 60 previously identified cohorts, will provide the resource for constructing an updated version of FRAX comprising 2,138,428 participants with a follow-up of approximately 20 million person-years and 116,117 documented incident major osteoporotic fractures. For each known and candidate risk factor, multivariate hazard functions for hip fracture, major osteoporotic fracture and death will be tested using extended Poisson regression. Sex- and/or ethnicity-specific differences in the weights of the risk factors will be investigated. After meta-analyses of the cohort-specific beta coefficients for each risk factor, models comprising 10-year probability of hip and major osteoporotic fracture, with or without femoral neck bone mineral density, will be computed. CONCLUSIONS These assembled cohorts and described models will provide the framework for an updated FRAX tool enabling enhanced assessment of fracture risk (PROSPERO (CRD42021227266)).

Published
2022

34. A Model for Scalable and Balanced Accelerators for Graph Processing

Author

Fariborz, M, Fariborz, M, Samani, M, O'Neill, T, Lowe-Power, J, Yoo, SJB, Akella, V, Fariborz, M, Fariborz, M, Samani, M, O'Neill, T, Lowe-Power, J, Yoo, SJB, and Akella, V

Abstract

Designing a graph processing system that can scale to graph sizes that are orders of magnitude larger than what is possible on a single accelerator requires a careful codesign of accelerator memory bandwidth and capacity, the interconnect bandwidth between accelerators, and the overall system architecture. We present a high-level bottleneck-analysis model for design and evaluation of scalable and balanced accelerators for graph processing. We show several applications of this model including how to choose the right mix of different memory types, network topology, network bisection bandwidth, and system-level architecture to match the access patterns and capacity requirements of different data structures for a given graph and a performance target.

Published
2022

35. Vertebral Scheuermann’s disease in Europe: prevalence, geographic variation and radiological correlates in men and women aged 50 and over

Author

Armbrecht, G., Felsenberg, D., Ganswindt, M., Lunt, M., Kaptoge, S. K., Abendroth, K., Aroso, A., Banzer, D., Bhalla, A. K., Dequeker, J., Eastell, R., Hoszowski, K., Lyritis, G., Delmas, P. D., Masaryk, P., Miazgowski, T., Cannata, J., Nuti, R., Oei, L., Poor, G., Redlund-Johnell, I., Reid, D. M., Reisinger, W., Schatz, H., Todd, C. J., Woolf, A. D., Javaid, K., Rivadeneira, F., Silman, A. J., Cooper, C., O’Neill, T. W., Reeve, J., and On behalf of the European Vertebral Osteoporosis Study (EVOS) and European Prospective Osteoporosis Study (EPOS) Groups

Published
2015
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39. Intra-articular therapies: patient preferences and professional practices in European countries

Author

De la Torre-Aboki J, Uson J, Pitsillidou I, Vardanyan V, Nikiphorou E, Rodriguez-Garcia S, Castellanos-Moreira R, Pandit H, O'Neill T, Doherty M, Boesen M, Moller I, Terslev L, D'Agostino M, Kampen W, Berenbaum F, Naredo E, and Carmona L

Subjects
Infiltrations, education, Patient's experience, Clinical practice, Surveys, Glucocorticoids, Intraarticular therapies
Abstract

To assess patient perspective and professional practice of intraarticular therapies (IATs) across Europe, an expert international multidisciplinary panel designed two open web-based surveys: one targeting people who had experienced at least two IATs (44 items); and one targeting health care providers (HCPs) (160 items). Surveys were disseminated via patient and professional associations and social media. A descriptive analysis was performed. The surveys were answered by 200 patients and 186 HCPs from 26 countries, showing that IAT is routinely performed by rheumatologists (97%) and orthopaedic surgeons (89%), with specific training being compulsory in a few countries. The most frequent indications for IAT are arthritis (76%), osteoarthritis (74%), crystal arthritis (71%) and bursitis (70%); the most frequently injected joints are knee (78%) and shoulder (70%); and the most used compounds are glucocorticoids. The majority of HCPs report informing patients about side-effects (73%), benefits (72%), and the nature of the procedure (72%), which coincides with 27% of patients reporting that they had not been informed about benefits or potential complications of IATs; 73% of patients had not been asked whether they wanted an anaesthetic. Few HCPs (10%) obtain written consent (56% get oral consent, being mandatory for 32%), a procedure deemed necessary by 41% of the patients. 50% of patients reported a clear benefit of IAT and 20% experienced complications including pain, impaired mobility, rashes, or swelling. In summary, the practice of IAT is variable across Europe, and although patients perceive it as relatively safe and usually effective procedure, some gaps were identified.

Published
2022

43. Effect of Vitamin D supplementation on synovial tissue volume and subchondral bone marrow lesion volume in symptomatic knee osteoarthritis

Author

Perry, T, Parkes, M, Hodgson, R, Felson, D, O’Neill, T, and Arden, N

Subjects
Male, bone marrow lesions (BMLs), Time Factors, lcsh:Diseases of the musculoskeletal system, Knee Joint, vitamin D, Double-Blind Method, Bone Marrow, Bone marrow lesions (BMLs), Osteoarthritis, Humans, Vitamin D, Aged, Cholecalciferol, Synovitis, Synovial Membrane, Vitamins, Middle Aged, Osteoarthritis, Knee, Magnetic Resonance Imaging, osteoarthritis, Treatment Outcome, England, Female, lcsh:RC925-935, synovitis, Research Article
Abstract

Background Data from a recent clinical trial of vitamin D therapy in knee OA suggests that, compared to placebo, vitamin D therapy may be associated with a reduction in effusion-synovitis. Our aim was, using contrast-enhanced (CE) magnetic resonance imaging (MRI), to examine the effect of vitamin D therapy on synovial tissue volume (STV) and also subchondral bone marrow lesion (BML) volume in men and women with symptomatic knee OA. Methods Data was acquired from participants who took part in a randomised placebo-controlled trial (UK VIDEO) investigating the effect of vitamin D therapy (800 IU cholecalciferol daily) on radiographic joint space narrowing. A subsample had serial CE MRI scans acquired during the trial. Subjects with serial images were assessed (N = 50) for STV and subchondral BML volume. The difference in the mean change from baseline in these structural outcomes between intervention and placebo groups was assessed using random-effects modelling. Results The mean age of the 50 subjects (24 active group, 26 placebo group) who contributed data to the analysis was 63.3 years (SD 6.5) and 74% were female. There was no significant difference at 2 years follow-up between the vitamin D and placebo groups in the mean change from baseline for STV (93.9 mm3, 95% CI -1605.0 to 1792.7) and subchondral BML volume (− 313.5 mm3, 95% CI -4244.7 to 3617.7). Conclusions Vitamin D supplementation does not appear to have an effect on synovitis or BML volume in patients with symptomatic knee OA. Trial registration VIDEO was registered with EudraCT: ref. 2004-000169-37. The protocol for the trial can be accessed at https://www.ctu.mrc.ac.uk/studies/all-studies/v/video/ Electronic supplementary material The online version of this article (10.1186/s12891-019-2424-4) contains supplementary material, which is available to authorized users.

Published
2019

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