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2. Interventions that have potential to help older adults living with social frailty: a systematic scoping review

Author

Kastner, Monika, Herrington, Isabella, Makarski, Julie, Amog, Krystle, Bain, Tejia, Evangelista, Vianca, Hayden, Leigh, Gruber, Alexa, Sutherland, Justin, Sirkin, Amy, Perrier, Laure, Graham, Ian D., Greiver, Michelle, Honsberger, Joan, Hynes, Mary, Macfarlane, Charlie, Prasaud, Leela, Sklar, Barbara, Twohig, Margo, Liu, Barbara, Munce, Sarah, Marr, Sharon, O’Neill, Braden, Papaioannou, Alexandra, Seaton, Bianca, Straus, Sharon E., Dainty, Katie, and Holroyd-Leduc, Jayna

Published
2024
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4. User-Generated Online Health Content: A Survey of Internet Users in the United Kingdom

Author

O'Neill, Braden, Ziebland, Sue, Valderas, Jose, and Lupiáñez-Villanueva, Francisco

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundThe production of health information has begun to shift from commercial organizations to health care users themselves. People increasingly go online to share their own health and illness experiences and to access information others have posted, but this behavior has not been investigated at a population level in the United Kingdom. ObjectiveThis study aims to explore access and production of user-generated health content among UK Internet users and to investigate relationships between frequency of use and other variables. MethodsWe undertook an online survey of 1000 UK Internet users. Descriptive and multivariate statistical analyses were used to interpret the data. ResultsNearly one-quarter of respondents (23.7%, 237/1000) reported accessing and sharing user-generated health content online, whereas more than 20% (22.2%, 222/1000) were unaware that it was possible to do this. Respondents could be divided into 3 groups based on frequency of use: rare users (78.7%, 612/778) who accessed and shared content less than weekly, users (13.9%, 108/778) who did so weekly, and superusers (7.5%, 58/778) who did so on a daily basis. Superusers were more likely to be male (P

Published
2014
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6. Improving Equity Through Primary Care: Proceedings of the 2019 Toronto International Conference on Quality in Primary Care

Author

O'Neill, Braden, Ferrer, Robert, O'Brien, Patricia, Watt, Graham, Gottlieb, Laura, Pinto, Andrew, Willems, Sara, Currie, Jody, Harriott, Dawnmarie, Leitch, Jonathan, Zsager, Alexander, Kidd, Michael, and Kiran, Tara

Subjects
Health Services and Systems, Health Sciences, Clinical Research, Health Services, 8.1 Organisation and delivery of services, Health and social care services research, Generic health relevance, Good Health and Well Being, Congresses as Topic, Health Care Rationing, Health Equity, Health Resources, Humans, Internationality, Primary Health Care, Quality Improvement, Social Determinants of Health, health equity, primary health care, quality improvement, quality of health care, social determinants of health, Medical and Health Sciences, Studies in Human Society, General & Internal Medicine, Biomedical and clinical sciences, Health sciences, Human society
Abstract

Health equity allows people to reach their full health potential and receive high-quality care that is appropriate for them and their needs, no matter where they live, what they have, or who they are. It is a core element of quality in health care. Around the world, there are many efforts to improve equity through primary care. In order to advance these efforts, it is important to share successes and challenges. Building on our work with international stakeholders to identify key primary care research priorities, we organized the Toronto International Conference on Quality in Primary Care that was held on November 16, 2019. Participants from 8 countries took part. Key recommendations included the establishment of continuous relationships between providers and patients over time, relationships between providers in the health and social sectors, and resources supported proportionally to patient need. Solutions must be generated using team-based approaches that explicitly include people with who have experienced discrimination. Progress will require confronting structural determinants including racism, capitalism, and colonialism. Conference participants suggested practical solutions, such as developing a public transportation program for rural residents to improve community building and the ability to attend medical appointments, and identifying patients who have recently missed clinic visits that may benefit from additional care. These approaches will need to be evaluated through high-quality research and quality improvement, with a knowledge translation that facilitates sustainability and expansion across settings.

Published
2020

9. Critical appraisal of evidence supporting prescription of psychedelics from clinic websites in Ontario, Canada.

Author

Kim, Kyurim, Yusuf, Abban, Sud, Abhimanyu, Persaud, Nav, Kirubarajan, Abirami, Moller, Monique, Lloyd, Taryn, and O'Neill, Braden

Abstract

Psychedelics, including ketamine, 3,4-Methyl enedioxy methamphetamine (MDMA), and psilocybin, have gained attention for their potential therapeutic role in mental health treatment. While recreational use is prohibited in Canada, medicinal exemptions can be granted. There are several psychedelic clinics in Ontario, Canada, promoting the use of psychedelics for a variety of medical indications. Our objective was to identify the indications for which psychedelics are being prescribed in Ontario clinics and assess the quality of evidence used to support these claims. Internet searches were conducted using Google and Bing to identify psychedelic clinics in Ontario. Inclusion criteria was as follow: clinics were physically located in Ontario, had a functioning website link, and demonstrated involvement of a licensed physician or nurse practitioner. Identified clinics were evaluated for their claims of effectiveness, the quality of evidence used to support these claims, and statements on psychedelic-related harms. The cited studies were appraised for quality using Oxford Centre for Evidence-Based Medicine Levels of Evidence, "level 5" being the lowest quality and "level 1" being the highest quality. Out of 200 search results, 10 psychedelic clinic websites met our inclusion criteria. These clinics advertised psychedelics for 47 medical conditions, most commonly for depression. Only 2 out of 10 clinics described potential risks associated with psychedelic use. There were 29 studies cited by these websites, majority coming from "level 4" evidence consisting of case-series and case-control studies. Overall, the cited evidence quality was low to moderate. Psychedelic clinics in Ontario promote a wide range of medical indications for psychedelics using primarily low to moderate "level 4" evidence. There is limited information shared on the potential adverse effects of psychedelics. Our study emphasizes the importance of using transparent and high-quality evidence by clinics and clinicians to ensure safe and effective use of psychedelics in mental health treatments. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Guidelines and recommendations about virtual mental health services from high-income countries: a rapid review

Author

Ekeleme, Ngozichukwuka, primary, Yusuf, Abban, additional, Kastner, Monika, additional, Waite, Karen, additional, Montesanti, Stephanie, additional, Atherton, Helen, additional, Salvalaggio, Ginetta, additional, Langford, Lucie, additional, Sediqzadah, Saadia, additional, Ziegler, Carolyn, additional, Do Amaral, Tamara, additional, Melamed, Osnat C, additional, Selby, Peter, additional, Kelly, Martina, additional, Anderson, Elizabeth, additional, and O'Neill, Braden, additional

Published
2024
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12. Enhancing community-oriented care: Implementation of social prescribing within a family health team

Author

Yusuf, Abban, Adose, Orit, Basnet, Sandesh, Bernales, Mikhaila, Vahidi-Williams, Nassim, Bloch, Gary, Kopansky-Giles, Deborah, Weyman, Karen, and O’Neill, Braden

Abstract

High quality comprehensive primary care is essential for the health and well-being of individuals and communities, but the provision of health services is inadequate to fully address these needs. Social isolation and loneliness are associated with poor health outcomes and are increasingly prevalent among older adults. The St. Michael’s Hospital Academic Family Health Team, a large interdisciplinary primary care organization that serves approximately 55,000 people in the downtown east of Toronto, Ontario, developed and implemented a social prescribing program to support socially isolated and lonely older adults. This article reports the development of that program—called SEED (Seniors, Equity, Engagement, and Dignity)—and describes opportunities and challenges and some preliminary results from the first year. By supporting people in new ways, this program aims to reduce loneliness and social isolation, increase capacity within the family health team, and support diverse older adults to live fulfilling lives.

Published
2024
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13. Effective Modalities of Virtual Care to Deliver Mental Health and Addictions Services in Canada

Author

Lo, Brian, primary, Strudwick, Gillian, additional, Mah, Linda, additional, Mushquash, Christopher J., additional, McKenzie, Kwame, additional, Khenti, Akwatu, additional, Crawford, Allison, additional, Bhattacharya, Onil, additional, Allen, Upton, additional, Bodmer, Nicolas S., additional, Born, Karen B., additional, Perkhun, Anna, additional, Razak, Fahad A., additional, and O'Neill, Braden, additional

Published
2022
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14. Prototyping the implementation of a suicide prevention protocol in primary care settings using PDSA cycles: a mixed method study

Author

Minian, Nadia, primary, Gayapersad, Allison, additional, Coroiu, Adina, additional, Dragonetti, Rosa, additional, Zawertailo, Laurie, additional, Zaheer, Juveria, additional, O’Neill, Braden, additional, Lange, Shannon, additional, Thomson, Nicole, additional, Crawford, Allison, additional, Kennedy, Sidney H., additional, and Selby, Peter, additional

Published
2024
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20. Examining the role of health literacy in online health information

Author

O'Neill, Braden Gregory, Ziebland, Sue, and Powell, John

Subjects
362.10285, Primary care (Medicine), Clinical epidemiology, Consumer health informatics, Health literacy, Online health information, Realist evaluation, Realist review
Abstract

The internet has radically changed the way people obtain and interact with information about diseases, treatments, and conditions. Yet, our understanding of how people access and use health information to make decisions- in other words, their health literacy- has not progressed. The overall aim of this thesis is to assess the extent to which health literacy is a valid and useful construct for policy and practice related to online health resources. A mixed-methods research programme of five studies was undertaken, influenced by realist evaluation methodology. First, to ascertain engagement with user-generated online health content (UGC) in the UK, analysis of a large European survey was undertaken. Then, the uncertainty regarding the relationship between health literacy and outcomes was addressed by a systematic review and qualitative analysis of health literacy measures. Results of these two studies informed interviews carried out with 13 'key informants': policymakers and primary care clinicians in the UK with a particular interest in health literacy and/or online information. A systematic review, incorporating a traditional narrative review and a realist review, evaluated existing trials addressing how effects of online resources vary by health literacy level. Finally, data were analysed from a feasibility randomized controlled trial, comparing usage and outcomes of accessing a 'personal experiences'-based asthma website (representing curated user-generated content) versus a 'facts and figures'-based website. Participant health literacy was assessed using an index identified from the systematic review of measures, and website usage was tracked. Approximately 25% of UK internet users engage with UGC at least monthly. The most frequent users were younger, more likely to be male, and to be carers for someone with a long-term illness. Three themes were identified from health literacy measurement: 'appropriate health decisions', 'ability to obtain healthcare services', and 'confidence'. Key informants noted the lack of clarity about how health literacy influences outcomes, and suggested that personal preferences and digital access and skills may be more relevant than health literacy for policy and practice. Existing trials of online resources in which participant health literacy was measured were mostly at high risk of bias; some possible explanations of how these interventions should work in people with low health literacy were that they may experience higher data entry burden related to chronic diseases, and that they may prefer simulated face-to-face communication. Finally, there were no differences between health literacy groups in the feasibility trial regarding usage or outcomes related to either the 'facts and figures' or 'personal experiences' websites. Taken together, these results question the validity and appropriateness of health literacy as a key objective or consideration in the development or use of online resources. While health literacy has value as a general idea, this thesis demonstrates that it may no longer be the right construct to guide intervention development and implementation to improve health outcomes.

Published
2014

21. Systematic assessment of opioid advertisements in general medical journals

Author

Kirubarajan, Abirami, Got, Tiffany, Persaud, Nav, and O’Neill, Braden

Subjects
Research, General Medicine, Family Practice
Abstract

OBJECTIVE: To systematically examine the content of opioid-related advertisements. DESIGN: Content analysis and quantitative assessment. SETTING: North America. PARTICIPANTS: Researchers examined advertisements in 2 issues per year from 1996 to 2016 of American Family Physician, Canadian Family Physician, the Canadian Medical Association Journal, JAMA, and the New England Journal of Medicine. MAIN OUTCOME MEASURES: Number of advertisements, nature of the claims made, and quality of cited evidence in the advertisements. RESULTS: Opioid advertisements composed 89 of the 3173 pharmaceutical advertisements in 210 journal issues searched. Seventy-three advertisements were able to be obtained for analysis. Thirty-four (46.6%) did not mention the addictive potential of opioids, and 54 of 73 (74.0%) did not mention the possibility of death. All referenced studies in advertisements were funded by pharmaceutical organizations or had pharmaceutical company employees as authors. No advertisements cited high-quality evidence. CONCLUSION: Many claims of the effectiveness and safety of opioids were published in medical journals through advertisements. Advertisements did not usually mention key negative information about opioids. Although the extent to which these advertisements directly influenced the development of the opioid crisis in North America is unknown, the marked omission of important detrimental effects of opioids may have played a role. Further efforts to restrict opioid marketing may be warranted.

Published
2023

22. Burnout in Hospital-Based Healthcare Workers during COVID-19

Author

Maunder, Robert G., primary, Heeney, Natalie D., additional, Strudwick, Gillian, additional, Shin, Hwayeon Danielle, additional, O'Neill, Braden, additional, Young, Nancy, additional, Jeffs, Lianne P., additional, Barrett, Kali, additional, Bodmer, Nicolas S., additional, Born, Karen B., additional, Hopkins, Jessica, additional, Jüni, Peter, additional, Perkhun, Anna, additional, Price, David J., additional, Razak, Fahad, additional, Mushquash, Christopher J., additional, and Mah, Linda, additional

Published
2021
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23. The Impact of the COVID-19 Pandemic on Opioid-Related Harm in Ontario

Author

Friesen, Erik L., primary, Kurdyak, Paul A., additional, Gomes, Tara, additional, Kolla, Gillian, additional, Leece, Pamela, additional, Zhu, Lynn, additional, Toombs, Elaine, additional, O'Neill, Braden, additional, Stall, Nathan M., additional, Jüni, Peter, additional, Mushquash, Christopher J., additional, and Mah, Linda, additional

Published
2021
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25. Tolerability of bedtime diuretics: a prospective cohort analysis

Author

Garrison, Scott R, primary, Kelmer, Michael, additional, Korownyk, Tina, additional, Kolber, Michael R, additional, Allan, Gary Michael, additional, Bakal, Jeffrey, additional, Singer, Alexander, additional, Katz, Alan, additional, Mcalister, Finlay, additional, Padwal, Raj S, additional, Lewanczuk, Richard, additional, Hill, Michael D, additional, McGrail, Kimberlyn, additional, O’Neill, Braden, additional, Greiver, Michelle, additional, Manca, Donna P, additional, Mangin, Dee, additional, Wong, Sabrina T, additional, Kirkwood, Jessica E M, additional, McCormack, James P, additional, Yeung, Jack M S, additional, and Green, Lee, additional

Published
2023
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29. Interventions that can best support socially frail older adults during infectious disease outbreaks such as the COVID-19 pandemic: protocol for a scoping review

Author

Hynes, Mary, Pradaud, Leela, Seaton, Bianca, Dainty, Katie, O'Neill, Braden, Macfarlane, Charlie, Sklar, Barb, Twohig, Margo, Amog, Krystle, Brehaut, Jamie, Dr. Jayna Holroyd-Leduc, Sutherland, Justin, Kastner, Monika, Wong, Geoff, Straus, Sharon, Liu, Barbara, Honsberger, Joan, Hayden, Leigh, Herrinton, Isabella, Greiver, Michelle, Papaioannou, Alexandra, Marr, Sharon, Makarski, Julie, Lee, Joyce, Tejia Bain, Vianca Evangelista, Lewis, Iveta, Munce, Sarah, Graham, Ian, Perrier, Laure, and Gruber, Alexa

Subjects
Scoping review, Mental and Social Health, Older adults, Medicine and Health Sciences, COVID-19, Social frailty, Knowledge synthesis
Abstract

This is the registration of the protocol for a scoping review to identify social frailty interventions that can reduce social frailty or related concepts (e.g., social isolation, loneliness) during infectious disease outbreaks such as the COVID-19 pandemic.

Published
2023
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31. Association between new-onset anosmia and positive SARS-CoV-2 tests among people accessing outpatient testing in Toronto, Ontario: a retrospective cross-sectional study

Author

O’Neill, Braden, Kalia, Sumeet, Gill, Peter, Hum, Susan, Moran-Venegas, Carla, Stoller, Rebecca, Greiver, Michelle, Agarwal, Payal, Kirubarajan, Abirami, DeKoven, Samuel, Eisen, David, Pinto, Andrew, and Dunn, Sheila

Subjects
Adult, Male, Adolescent, Anosmia, Health Services Accessibility, Young Adult, Predictive Value of Tests, Risk Factors, Outpatients, Humans, Child, Aged, Retrospective Studies, Aged, 80 and over, Ontario, Diagnostic Tests, Routine, Reverse Transcriptase Polymerase Chain Reaction, SARS-CoV-2, Research, Infant, Newborn, COVID-19, Infant, General Medicine, Middle Aged, Cross-Sectional Studies, COVID-19 Nucleic Acid Testing, Child, Preschool, Female
Abstract

Background: Reports have suggested that anosmia is strongly associated with SARS-CoV-2 infection, but patients were often asked about this symptom after their diagnosis. This study assessed associations between prospectively reported anosmia and other symptoms related to SARS-CoV-2 infection, and SARS-CoV-2 positivity in community testing centres in Toronto, Ontario. Methods: We conducted a retrospective cross-sectional study in which data were collected from 2 COVID-19 assessment centres affiliated with 2 hospitals in Toronto, Ontario, from Apr. 5 to Sept. 30, 2020. We included symptomatic profiles of all people who underwent a SARS-CoV-2 test at either clinic within the study period. We used generalized estimating equations to account for repeat visits and to assess associations between anosmia and other symptoms and SARS-CoV-2 positivity. Results: A total of 83 443 SARS-CoV-2 tests were conducted across the 2 sites for 72 692 participants during the study period. Of all tests, 1640 (2.0%) were positive; 837 (51.0%) of people who tested positive were asymptomatic. The adjusted odds ratio for the association between anosmia and test positivity was 5.29 (95% confidence interval [CI] 4.50–6.22), with sensitivity of 0.138 (95% CI 0.121–0.154), specificity of 0.980 (95% CI 0.979–0.981), a positive predictive value of 0.120 (95% CI 0.106–0.135) and a negative predictive value of 0.983 (95% CI 0.982–0.984). Interpretation: Anosmia had high specificity and a positive predictive value of 12% for SARS-CoV-2 infection in this community population with low prevalence of SARS-CoV-2 positivity. The presence of anosmia should increase clinical suspicion of SARS-CoV-2 infection, and our findings suggest that people presenting with this symptom should be tested.

Published
2021

32. Marginal structural models using calibrated weights with SuperLearner: application to longitudinal diabetes cohort.

Author

Kalia, Sumeet, primary, Greiver, Michelle, additional, Sullivan, Frank, additional, Sejdic, Ervin, additional, Escobar, Michael, additional, Gronsbell, Jessica, additional, O'Neill, Braden, additional, Meaney, Christopher, additional, Pow, Conrad, additional, Saarela, Olli, additional, Moineddin, Rahim, additional, Chen, Tao, additional, and Aliarzadeh, Babak, additional

Published
2022
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33. Marginal Structural Models Using Calibrated Weights With SuperLearner: Application to Type II Diabetes Cohort

Author

Kalia, Sumeet, primary, Saarela, Olli, additional, Chen, Tao, additional, O'Neill, Braden, additional, Meaney, Christopher, additional, Gronsbell, Jessica, additional, Sejdic, Ervin, additional, Escobar, Michael, additional, Aliarzadeh, Babak, additional, Moineddin, Rahim, additional, Pow, Conrad, additional, Sullivan, Frank, additional, and Greiver, Michelle, additional

Published
2022
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34. Disruptions in Primary Care among People with Schizophrenia in Ontario, Canada, During the COVID-19 Pandemic.

Author

Stephenson, Ellen, Yusuf, Abban, Gronsbell, Jessica, Tu, Karen, Melamed, Osnat, Mitiku, Tezeta, Selby, Peter, and O'Neill, Braden

Subjects
COVID-19 pandemic, BLOOD cell count, PRIMARY care, MEDICAL care, PEOPLE with schizophrenia
Abstract

Copyright of Canadian Journal of Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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36. General practitioners’ perceptions of using virtual primary care during the COVID-19 pandemic: An international cross-sectional survey study

Author

Li, Edmond, primary, Tsopra, Rosy, additional, Jimenez, Geronimo, additional, Serafini, Alice, additional, Gusso, Gustavo, additional, Lingner, Heidrun, additional, Fernandez, Maria Jose, additional, Irving, Greg, additional, Petek, Davorina, additional, Hoffman, Robert, additional, Lazic, Vanja, additional, Memarian, Ensieh, additional, Koskela, Tuomas, additional, Collins, Claire, additional, Espitia, Sandra Milena, additional, Clavería, Ana, additional, Nessler, Katarzyna, additional, O’Neill, Braden Gregory, additional, Hoedebecke, Kyle, additional, Ungan, Mehmet, additional, Laranjo, Liliana, additional, Ghafur, Saira, additional, Fontana, Gianluca, additional, Majeed, Azeem, additional, Car, Josip, additional, Darzi, Ara, additional, and Neves, Ana Luisa, additional

Published
2022
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38. Health system use among patients with mental health conditions in a community based sample in Toronto, Canada: A retrospective cohort study

Author

Lazare, Kimberly, primary, Kalia, Sumeet, additional, Aliarzadeh, Babak, additional, Bernard, Steven, additional, Moineddin, Rahim, additional, Eisen, David, additional, Greiver, Michelle, additional, Kaplan, David, additional, Koczerginski, David, additional, Muraca, Maria, additional, Fung, Wai Lun Alan, additional, and O’Neill, Braden, additional

Published
2022
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39. Authors' reply

Author

Heneghan, Carl, Thompson, Matthew, Perera-Salazar, Rafael, Gill, Peter, O'Neill, Braden, Nunan, David, Howick, Jeremy, Lasserson, Daniel, and Mahtani, Kamal

Published
2012

43. Primary Care Severe Asthma Registry and Education Project (PCSAR-EDU): Phase 1 – an e-Delphi for registry definitions and indices of clinician behaviour

Author

D'Urzo, Katrina A, primary, Tamari, Itamar E, additional, Chapman, Kenneth R, additional, Maleki-Yazdi, M Reza, additional, Greiver, Michelle, additional, Upshur, Ross EG, additional, Biro, Lana, additional, O'Neill, Braden, additional, Moineddin, Rahim, additional, Aliarzadeh, Babak, additional, Kulasegaram, Kulamakan, additional, To, Teresa, additional, and D'Urzo, Anthony D, additional

Published
2022
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44. Bedtime versus morning use of antihypertensives for cardiovascular risk reduction (BedMed): protocol for a prospective, randomised, open-label, blinded end-point pragmatic trial

Author

Garrison, Scott R, primary, Kolber, Michael R, additional, Allan, G Michael, additional, Bakal, Jeffrey, additional, Green, Lee, additional, Singer, Alexander, additional, Trueman, Darryl R, additional, McAlister, Finlay A, additional, Padwal, Raj S, additional, Hill, Michael D, additional, Manns, Braden, additional, McGrail, Kimberlyn, additional, O'Neill, Braden, additional, Greiver, Michelle, additional, Froentjes, Liesbeth S, additional, Manca, Donna P, additional, Mangin, Dee, additional, Wong, Sabrina T, additional, MacLean, Cathy, additional, Kirkwood, Jessica EM, additional, McCracken, Rita, additional, McCormack, James P, additional, Norris, Colleen, additional, and Korownyk, Tina, additional

Published
2022
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45. sj-docx-1-cpa-10.1177_07067437221140384 - Supplemental material for Disruptions in Primary Care among People with Schizophrenia in Ontario, Canada, During the COVID-19 Pandemic

Author

Stephenson, Ellen, Yusuf, Abban, Gronsbell, Jessica, Tu, Karen, Melamed, Osnat, Mitiku, Tezeta, Selby, Peter, and O’Neill, Braden

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy)
Abstract

Supplemental material, sj-docx-1-cpa-10.1177_07067437221140384 for Disruptions in Primary Care among People with Schizophrenia in Ontario, Canada, During the COVID-19 Pandemic by Ellen Stephenson, Abban Yusuf and Jessica Gronsbell, Karen Tu, Osnat Melamed, Tezeta Mitiku, Peter Selby, Braden O’Neill in The Canadian Journal of Psychiatry

Published
2022
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46. Additional file 1 of Socioeconomic and immigration status and COVID-19 testing in Toronto, Ontario: retrospective cross-sectional study

Author

O’Neill, Braden, Kalia, Sumeet, Hum, Susan, Gill, Peter, Greiver, Michelle, Kirubarajan, Abirami, Eisen, David, Ferguson, Jacob, and Dunn, Sheila

Subjects
stomatognathic system, mental disorders, psychological phenomena and processes
Abstract

Additional file 1: Table S1. Odds ratios for positive COVID-19 swab test. Table S2. Positivity rate of COVID-19 swab test with respect to interaction between immigration terciles and income quintiles.

Published
2022
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47. Benefits and Challenges of Using Virtual Primary Care During the COVID-19 Pandemic: An International Cross-sectional Survey Study (Preprint)

Author

Li, Edmond, primary, Tsopra, Rosy, additional, Jimenez, Geronimo, additional, Serafini, Alice, additional, Gusso, Gustavo, additional, Lingner, Heidrun, additional, Fernandez, Maria Jose, additional, Irving, Greg, additional, Petek, Davorina, additional, Hoffman, Robert, additional, Lazic, Vanja, additional, Memarian, Ensieh, additional, Koskela, Tuomas H, additional, Collins, Claire, additional, Espitia, Sandra Milena, additional, Clavería, Ana, additional, Nessler, Katarzyna, additional, O’Neill, Braden Gregory, additional, Hoedebecke, Kyle, additional, Ungan, Mehmet, additional, Laranjo, Liliana, additional, Ghafur, Saira, additional, Fontana, Gianluca, additional, Majeed, Azeem, additional, Car, Josip, additional, Darzi, Ara, additional, and Neves, Ana Luísa, additional

Published
2021
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48. Evaluating the Impact of COVID-19 on the Adoption of Virtual Care in General Practice in 20 Countries (inSIGHT): Protocol and Rationale Study

Author

Neves, Ana Luísa, primary, Li, Edmond, additional, Serafini, Alice, additional, Jimenez, Geronimo, additional, Lingner, Heidrun, additional, Koskela, Tuomas H, additional, Hoffman, Robert D, additional, Collins, Claire, additional, Petek, Davorina, additional, Claveria, Ana, additional, Tsopra, Rosy, additional, Irving, Greg, additional, Gusso, Gustavo, additional, O’Neill, Braden Gregory, additional, Hoedebecke, Kyle, additional, Espitia, Sandra Milena, additional, Ungan, Mehmet, additional, Nessler, Katarzyna, additional, Lazic, Vanja, additional, Laranjo, Liliana, additional, Memarian, Ensieh, additional, Fernandez, Maria Jose, additional, Ghafur, Saira, additional, Fontana, Gianluca, additional, Majeed, Azeem, additional, Car, Josip, additional, and Darzi, Ara, additional

Published
2021
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50. Trends in diabetes medication use in Canada, England, Scotland and Australia : a repeated cross-sectional analysis (2012-2017)

Author

Greiver, Michelle, Havard, Alys, Kuster Filipe Bowles, Juliana, Kalia, Sumeet, Chen, Tao, Aliarzadeh, Babak, Moineddin, Rahim, Sherlock, Julian, Hinton, William, Sullivan, Francis, O'Neill, Braden, Pow, Conrad, Bhatt, Aashka, Rahman, Fahrurrozi, Meza-Torres, Bernardo, Litchfield, Melisa, de Lusignan, Simon, University of St Andrews. School of Computer Science, University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis, University of St Andrews. Population and Behavioural Science Division, and University of St Andrews. School of Medicine

Subjects
MCC, QA75, RM, Pharmacoepidemiology, QA75 Electronic computers. Computer science, 3rd-DAS, RM Therapeutics. Pharmacology, Drug Therapy, SDG 3 - Good Health and Well-being, Diabetes mellitus, Type 2, RA0421, RA0421 Public health. Hygiene. Preventive Medicine, Electronic health records, Primary healthcare
Abstract

Funding: This study was supported by Diabetes Action Canada which is funded, in part, through a Canadian Institutes of Health Research chronic disease network grant under the Strategy for Patient-Oriented Research (Funding Reference number: SCA 145101). Dr Greiver is supported through the Gordon F. Cheesbrough Research Chair in Family and Community Medicine from North York General Hospital. Acquisition of the PBS 10% sample data was supported by a NHMRC Centre of Research Excellence Grant (#1060407) and a Cooperative Research Centre Project Grant from the Australian Department of Industry, Innovation and Science (CRC-P-439). AH was supported by a NSW Health Early-Mid Career Fellowship. Background Several new classes of glucose lowering medications have been introduced in the past two decades. Some, such as Sodium-glucose cotransporter 2 inhibitors (SGLT2s), have evidence of improved cardiovascular outcomes, while others, such as Dipeptidyl peptidase-4 inhibitors (DPP4s), do not. It is therefore important to identify their uptake, in order to find ways to support the use of more effective medications. Aims We studied the uptake of these new classes amongst patients with type 2 diabetes. Design and setting Retrospective repeated cross-sectional analysis. We compared rates of medication uptake in Australia, Canada, England and Scotland. Method We used primary care Electronic Medical Data on prescriptions (Canada, UK) and dispensing data (Australia) from 2012 to 2017. We included persons aged 40 years or over on at least one glucose-lowering drug class in each year of interest, excluding those on insulin only. We determined proportions of patients in each nation, for each year, on each class of medication, and on combinations of classes. Results By 2017, data from 238,609 patients were included. The proportion of patients on sulfonylureas (SUs) decreased in three out of four nations, while metformin decreased in Canada. Use of combinations of metformin and new drug classes increased in all nations, replacing combinations involving SUs. In 2017 more patients were on DPP4s (between 19.1% and 27.6%) than on SGLT2s (between 10.1% and 15.3%). Conclusions New drugs are displacing SUs. However, despite evidence of better outcomes, the adoption of SGLT2s lagged behind DPP4s. Publisher PDF

Published
2021

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