1. Feasibility of Continuous Infusions of Acyclovir.
- Author
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O'Leary CK, Jones C, Bryant PA, Abo YN, Osowicki J, and Gwee A
- Subjects
- Acyclovir standards, Acyclovir therapeutic use, Antiviral Agents therapeutic use, Brain diagnostic imaging, Brain virology, Feasibility Studies, Female, Humans, Infant, Newborn, Infusions, Intravenous methods, Magnetic Resonance Imaging, Male, Treatment Outcome, Acyclovir administration & dosage, Antiviral Agents administration & dosage, Encephalitis, Herpes Simplex diagnostic imaging, Encephalitis, Herpes Simplex drug therapy, Infusions, Intravenous standards
- Abstract
Current guidelines for severe herpes simplex virus infection recommend 21 days of intravenous therapy. The thrice-daily administration of intravenous acyclovir makes it challenging to deliver as outpatient therapy. We describe 2 cases with confirmed or presumed neonatal herpes simplex virus encephalitis treated with acyclovir administered as a continuous-infusion at home and review the pharmacologic and clinical evidence for continuous infusions of acyclovir.
- Published
- 2020
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