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8. Me and My Body (MAMBO): An Interactive Science Education Programme for Primary Schools

Author

Scalzo, Clare, Killard, Fiona, MacCormac, Aoife, Fryar, James, O' Brien, Emma, and O'Kennedy, Richard

Abstract

This paper describes a novel science education initiative developed for 8-to 12-year-old children by the Biomedical Diagnostics Institute at Dublin City University, Ireland. "Me and My Body" (MAMBO) is an interactive, multi-faceted programme that enables children to explore and understand the dynamic physiological parameters of the human body using simple sensing and diagnostic devices. The programme consists of a number of complementary elements comprising a colourfully animated website, a classroom-based series of lessons taught by a visiting educator, a curriculum-linked resource CD for teachers, and an out-of-school workshop. Topics investigated by the children include the blood, immune system, heart, and healthy living. The introduction of the programme into Irish primary schools has been met with enthusiastic responses from both students and teachers.

Published
2008

21. Evaluation of a point-of-use device used for autoantibody analysis and its potential for following microcystin leucine-arginine exposure.

Author

Hui Ma, Loscher, Christine, Parle-McDermott, Anne, Fitzgerald, Jenny, Meneely, Julie, Elliott, Christopher, Welten, Richard, Mchau, Geofrey J., Makule, Edna, Machunda, Revocatus, Yun Yun Gong, Kimanya, Martin, Crawley, Aoife, Maguire, Ivan, Murphy, Caroline, and O'Kennedy, Richard

Subjects
AUTOANTIBODY analysis, AUTOANTIBODIES, HEAT shock proteins, SHELLFISH populations, TRIOSE-phosphate isomerase, ALGAL toxins, LEUCINE, ARGININE
Abstract

Introduction: Globally, the need for measuring exposure to algal toxins has become urgent due to ever-increasing reports of contamination in sea and freshwater, in shellfish and fish stocks and in aerosols. Methods: To address this issue, we evaluated the potential of determining autoantibodies to a panel of biomarkers known to be elevated following exposure to the hepatotoxin microcystin leucine-arginine. The presence of autoantibodies, specific to four selected stress-response, metabolomic and chaperone biomarkers, namely, Heat shock protein 1, Triosephosphate isomerase, Peroxiredoxin 1 and Peroxiredoxin 2 was employed in screening 371 serum samples from microcystin-exposed individuals in Tanzania. In addition, the capacity of the LightDeck fluorescence-based detector, a point-of-use device, to monitor these autoantibody responses in comparison to enzyme-linked immunosorbent assay was evaluated. Results: By using the determination of autoantibodies to this novel panel of biomarkers an altered response was observed following microcystin exposure, with levels generally upregulated. The presence of elevated levels of microcystin leucine-arginine in water, as well as in food sources in Tanzania, may potentially have significant health effects on the population. Discussion: This novel biomarker panel may have potential for the detection of microcystin leucine-arginine exposure as well as various microcystin exposure-associated cancers (e.g., hepatocellular cancer and colorectal cancer). In addition, the utilisation of the LightDeck point-of-use device proved successful for the rapid analysis of this biomarker panel. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Mycofluidics

Author

Loftus, Jonathan H., primary, Kijanka, Gregor S., additional, and O’Kennedy, Richard, additional

Published
2017
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49. Diagnosis, monitoring and prevention of exposure-related non-communicable diseases in the living and working environment: DiMoPEx-project is designed to determine the impacts of environmental exposure on human health

Author

Budnik, Lygia Therese, Adam, Balazs, Albin, Maria, Banelli, Barbara, Baur, Xaver, Belpoggi, Fiorella, Bolognesi, Claudia, Broberg, Karin, Gustavsson, Per, Göen, Thomas, Fischer, Axel, Jarosinska, Dorota, Manservisi, Fabiana, O’Kennedy, Richard, Øvrevik, Johan, Paunovic, Elizabet, Ritz, Beate, Scheepers, Paul T. J., Schlünssen, Vivi, Schwarzenbach, Heidi, Schwarze, Per E., Sheils, Orla, Sigsgaard, Torben, Van Damme, Karel, and Casteleyn, Ludwine

Published
2018
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50. The Development of a Multi-Disciplinary Educational Programme in Biomedical Diagnostics: A Novel Approach

Author

MacCormac, Aoife, O'Brien, Emma, and O'Kennedy, Richard

Abstract

This paper describes the development of a taught Master's course in biomedical diagnostics using a novel multi-disciplinary approach. This course, the first of its kind in Ireland, covers the science and technology underlying the development of medical diagnostic devices that detect early markers of diseases such as cancer. The ethical impact of these devices on society, the importance of scientific communication, relevant aspects of business entrepreneurial studies and the commercialisation of medical devices are also covered. The course consists of a mixture of theory, intensive laboratory practicals and independent research. The challenges faced in setting up and running the course are described, as well as some of the novel aspects and may provide valuable insight to those involved in the development of high-level Master's courses. (Contains 2 figures and 2 tables.)

Published
2011
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