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299 results on '"O'Huigin, Colm"'

5. HLA tapasin independence : broader peptide repertoire and HIV control

Author

Bashirova, Arman A., Viard, Mathias, Naranbhai, Vivek, Grifoni, Alba, Garcia-Beltran, Wilfredo, Akdag, Marjan, Yuki, Yuko, Gao, Xiaojiang, O’hUigin, Colm, Raghavan, Malini, Wolinsky, Steven, Bream, Jay H., Duggal, Priya, Martinson, Jeremy, Michael, Nelson L., Kirk, Gregory D., Buchbinder, Susan P., Haas, David, Goedert, James J., Deeks, Steven G., Fellay, Jacques, Walker, Bruce, Goulder, Philip, Cresswell, Peter, Elliott, Tim, Sette, Alessandro, Carlson, Jonathan, and Carrington, Mary

Published
2020

7. Role of HLA-B exon 1 in graft-versus-host disease after unrelated haemopoietic cell transplantation: a retrospective cohort study

Author

Petersdorf, Effie W, Carrington, Mary, O'hUigin, Colm, Bengtsson, Mats, De Santis, Dianne, Dubois, Valerie, Gooley, Ted, Horowitz, Mary, Hsu, Katharine, Madrigal, J Alejandro, Maiers, Martin, Malkki, Mari, McKallor, Caroline, Morishima, Yasuo, Oudshoorn, Machteld, Spellman, Stephen, Villard, Jean, Stevenson, Phil, Apperley, Jane, Bardy, Peter, Bernard, Ghislaine, Bertrand, Yves, Bloor, Adrian, Bonini, Chiara, Buhler, Stephane, Bungener, Laura, Campbell, Helen, Carlson, Kristina, Carpenter, Ben, Cesbron, Anne, Chabannon, Christian, Chalandon, Yves, Chapman, Jeremy, Chebel, Réda, Chevallier, Patrice, Choi, Gerda, Collin, Matt, Cornelissen, Jan J, Crawley, Charles, D'Orsogna, Lloyd, Dalle, Jean-Hugues, Deconinck, Eric, DeMatteis, Muriel, Diviney, Mary, Dormoy, Anne, Gagne, Katia, Gibson, Brenda, Gilleece, Maria, Gottlieb, David, Gribben, John, Güngör, Tayfun, Haagenson, Mike, Hart, Cathie, Holdsworth, Rhonda, Humphreys, Ian, Kodera, Yoshihisa, Koh, Mickey, Labussière-Wallet, Hélène, Lankester, Arjan C, Lardy, Neubery, Lawson, Sarah, Leleu, Xavier, MacKinnon, Stephen, Malladi, Ram, Marsh, Steven GE, Martin, Murray, Mayor, Neema P, McQuaker, I Grant, Meijer, Ellen, Morishima, Satoko, Nikolousis, Emmanouil, Orchard, Kim, Passweg, Jacob, Patel, Amit, Patrick, Katherine, Pedron, Béatrice, Peniket, Andy, Perry, Julia, Petersen, Eefke, Potter, Victoria, Potter, Mike, Protheroe, Rachel, Raus, Nicole, Ruiz de Elvira, Carmen, Russell, Nigel, Schaap, Nicholaas PM, Schanz, Urs, Schouten, Harry, Skinner, Roderick, Snowden, John, Spierings, Eric, Steward, Colin, Tholouli, Eleni, Thornton, Alycia, Tilanus, Marcel, van de Meer, Arnold, Veelkens, Hendrik, Veys, Paul, Watson, Narelle, Weston, Lyanne, Wilson, Keith, Wilson, Marie, Wynn, Robert, Zsiros, József, Maiers, Martin J, and Spellman, Stephen R

Published
2020
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8. Impact of HLA class I functional divergence on HIV control

Author

Viard, Mathias, primary, O’hUigin, Colm, additional, Yuki, Yuko, additional, Bashirova, Arman A., additional, Collins, David R., additional, Urbach, Jonathan M., additional, Wolinsky, Steven, additional, Buchbinder, Susan, additional, Kirk, Gregory D., additional, Goedert, James J., additional, Michael, Nelson L., additional, Haas, David W., additional, Deeks, Steven G., additional, Walker, Bruce D., additional, Yu, Xu, additional, and Carrington, Mary, additional

Published
2024
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10. Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease

Author

Kulkarni, Smita, Qi, Ying, O’hUigin, Colm, Pereyra, Florencia, Ramsuran, Veron, McLaren, Paul, Fellay, Jacques, Nelson, George, Chen, Haoyan, Liao, Wilson, Bass, Sara, Apps, Richard, Gao, Xiaojiang, Yuki, Yuko, Lied, Alexandra, Ganesan, Anuradha, Hunt, Peter W, Deeks, Steven G, Wolinsky, Steven, Walker, Bruce D, and Carrington, Mary

Subjects
Biomedical and Clinical Sciences, Chemical Sciences, Immunology, Genetics, Autoimmune Disease, Sexually Transmitted Infections, Biotechnology, Infectious Diseases, Clinical Research, HIV/AIDS, 2.1 Biological and endogenous factors, Aetiology, 3' Untranslated Regions, Alleles, Base Sequence, Crohn Disease, Female, Gene Expression Regulation, HIV Infections, HLA-C Antigens, Humans, INDEL Mutation, Linkage Disequilibrium, Male, MicroRNAs
Abstract

Variation in the 3' untranslated region (3'UTR) of the HLA-C locus determines binding of the microRNA Hsa-miR-148a, resulting in lower cell surface expression of alleles that bind miR-148a relative to those alleles that escape its binding. The HLA-C 3'UTR variant was shown to associate with HIV control, but like the vast majority of disease associations in a region dense with causal candidates, a direct effect of HLA-C expression level on HIV control was not proven. We demonstrate that a MIR148A insertion/deletion polymorphism associates with its own expression levels, affecting the extent to which HLA-C is down-regulated, the level of HIV control, and the risk of Crohn disease only among those carrying an intact miR-148a binding site in the HLA-C 3'UTR. These data illustrate a direct effect of HLA-C expression level on HIV control that cannot be attributed to other HLA loci in linkage disequilibrium with HLA-C and highlight the rich complexity of genetic interactions in human disease.

Published
2013

11. FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis

Author

Liang, Weiwei, Peng, Xinjian, Li, Qingqing, Wang, Pingzhang, Lv, Ping, Song, Quansheng, She, Shaoping, Huang, Shiyang, Chen, Keqiang, Gong, Wanghua, Yuan, Wuxing, Thovarai, Vishal, Yoshimura, Teizo, O’huigin, Colm, Trinchieri, Giorgio, Huang, Jiaqiang, Lin, Shuye, Yao, Xiaohong, Bian, Xiuwu, Kong, Wei, Xi, Jianzhong, Wang, Ji Ming, and Wang, Ying

Published
2020
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17. JAMS - A framework for the taxonomic and functional exploration of microbiological genomic data

Author

McCulloch, John A., primary, Badger, Jonathan H., additional, Cannon, Nikki, additional, Rodrigues, Richard R., additional, Valencia, Michael, additional, Barb, Jennifer J., additional, Fernandes, Miriam R., additional, Balaji, Ascharya, additional, Crowson, Lisa, additional, O’hUigin, Colm, additional, Dzutsev, Amiran, additional, and Trinchieri, Giorgio, additional

Published
2023
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20. Additional file 1 of The beneficial effects of commensal E. coli for colon epithelial cell recovery are related with Formyl peptide receptor 2 (Fpr2) in epithelial cells

Author

Chen, Keqiang, McCulloch, John, Das Neves, Rodrigo, Roderigues, Gisele, Hsieh, Wang-Ting, Gong, Wanghua, Yoshimura, Teizo, Huang, Jiaqiang, O’hUigin, Colm, Difilippantonio, Simone, McCollum, Matthew, Jones, Georgette, Durum, Scott K., Trinchieri, Giorgio, and Wang, Ji Ming

Abstract

Additional file 1: Figure S1. Impaired colon mucosal barrier in Fpr2-/- mice. A. Reduced CRAMP production in colon crypts of Fpr2-/- mice. Red: CRAMP, Blue: Nuclei. Scale bar = 50 μm. Right panel: Quantitation of CRAMP+ fluorescence intensity, n = 18-20 crypts from 6 mice/group, ***P < 0.001. B. Reduced CRAMP level in the feces of Fpr2-/- mice. The concentration of CRAMP was expressed as pg/1 mg protein in stool. n = 8 mice/group, *P < 0.05. C. Reduced production of β-Defensin 2 in the colon crypts of Fpr2-/- mice. Red: β-Defensin 2, Blue: Nuclei. Scale bar = 50 μm. Right panel: Quantitation of β-Defensin 2+ fluorescence intensity, n = 20 crypts from 6 mice/group, ***P < 0.001. D. Reduced β-Defensin 2 level in the feces of Fpr2-/- mice. The concentration of β-Defensin 2 was expressed as pg/1 mg protein in stool. n = 8 mice/group, *P < 0.05. Figure S2. 16S rRNA gene sequencing. A. The result of 16S rRNA gene sequencing for E. coli isolated with Violet red bile lactose agarin this study. B. Comparison of 16S rRNA gene sequencing of E. coli isolated from VRBL in this study to that of other E. coli published in online. Figure S3. Comparison of 16S rRNA gene sequence of two different E. coli strains isolated from mouse feces. A small number of colonies of E. coli displayed differences in nucleotides #52, 113, 116, 136, 263, 293 and 424 as compared to most E. coli colonies. Figure S4. Similar phonotypes between two E. coli strains isolated from mouse feces. A. Similar results of Gram Staining for E. coli Type I and Type II. E. coli smear was stained with Gram Stain Kit. Red: Gram negative bacteria. Scale bar = 5 μm. B. Similar results of FISH with EC1531 probe for E. coli-Type I and Type II. E. coli smear was obtained by in situ hybridization with EC1531 probe conjugated to CY3. Red: EC1531+ bacteria. Scale bar = 5 μm. C. Similar results of PCR for E. coli-Type I and Type II. Colonies of E. coli from Type I and II were cultured in VRBL, respectively. Single colonies were then selected to expand in LB for 24 h and DNA was isolated followed by PCR amplification with E. coli primers.

Published
2023
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21. HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation

Author

Petersdorf, Effie W., Gooley, Theodore A., Malkki, Mari, Bacigalupo, Andrea P., Cesbron, Anne, Du Toit, Ernette, Ehninger, Gerhard, Egeland, Torstein, Fischer, Gottfried F., Gervais, Thibaut, Haagenson, Michael D., Horowitz, Mary M., Hsu, Katharine, Jindra, Pavel, Madrigal, Alejandro, Oudshoorn, Machteld, Ringdén, Olle, Schroeder, Marlis L., Spellman, Stephen R., Tiercy, Jean-Marie, Velardi, Andrea, Witt, Campbell S., O’Huigin, Colm, Apps, Richard, and Carrington, Mary

Published
2014
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25. The Accordion Model of Mhc Evolution

Author

Klein, Jan, Ono, Hideki, Klein, Dagmar, O’hUigin, Colm, Gergely, János, editor, Benczúr, M., editor, Erdei, Anna, editor, Falus, A., editor, Füst, Gy., editor, Medgyesi, G., editor, Petrányi, Gy., editor, and Rajnavölgyi, Éva, editor

Published
1993
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39. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

Author

Thomas, David L., Thio, Chloe L., Martin, Maureen P., Qi, Ying, Ge, Dongliang, O'hUigin, Colm, Kidd, Judith, Kidd, Kenneth, Khakoos, Salim I., Alexander, Graeme, Goedert, James J., Kirk, Gregory D., Donfield, Sharyne M., Rosen, Hugo R., Tobler, Leslie H., Busch, Michael P., McHutchison, John G., Goldstein, David B., and Carrington, Mary

Subjects
Viral genetics -- Research -- Genetic aspects -- Health aspects, Hepatitis C virus -- Genetic aspects -- Health aspects -- Research, Genetic variation -- Health aspects -- Genetic aspects -- Research, Hepatitis C -- Genetic aspects -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Hepatitis C virus (HCV) infection is the most common bloodborne infection in the United States, with estimates of 4 million HCV-infected individuals in the United States and 170 million Worldwide (1). Most (70-80%) HCV infections persist and about 30% of individuals with persistent infection develop chronic liver disease, including cirrhosis and hepatocellular carcinoma (2). Epidemiological, viral and host factors have been associated with the differences in HCV clearance or persistence, and studies have demonstrated that a strong host immune response against HCV favours viral clearance (3,4). Thus, variation in genes involved in the immune response may contribute to the ability to clear the virus. In a recent genome-wide association study, a single nucleotide polymorphism (rs12979860) 3 kilobases upstream of the IL28B gene, which encodes the type III interferon IFN-λ3, was shown to associate strongly with more than a twofold difference in response to HCV drug treatment (5). To determine the potential effect of rs12979860 variation on outcome to HCV infection in a natural history setting, we genotyped this variant in HCV cohorts comprised of individuals who spontaneously cleared the virus (n = 388) or had persistent infection (n = 620). We show that the C/C genotype strongly enhances resolution of HCV infection among individuals of both European and African ancestry. To our knowledge, this is the strongest and most significant genetic effect associated with natural clearance of HCV, and these results implicate a primary role for IL28B in resolution of HCV infection., Approximately 30% of individuals spontaneously clear acute HCV infection. Host genetic variation is assumed to explain the heterogeneity in HCV clearance across individuals because such differences occur even after exposure [...]

Published
2009

40. Role of HLA-B exon 1 in graft-versus-host disease after unrelated haemopoietic cell transplantation : a retrospective cohort study

Author

Petersdorf, Effie W., Carrington, Mary, O'hUigin, Colm, Bengtsson, Mats, De Santis, Dianne, Dubois, Valerie, Gooley, Ted, Horowitz, Mary, Hsu, Katharine, Madrigal, J. Alejandro, Maiers, Martin J., Malkki, Mari, McKallor, Caroline, Morishima, Yasuo, Oudshoorn, Machteld, Spellman, Stephen R., Villard, Jean, Stevenson, Phil, Petersdorf, Effie W., Carrington, Mary, O'hUigin, Colm, Bengtsson, Mats, De Santis, Dianne, Dubois, Valerie, Gooley, Ted, Horowitz, Mary, Hsu, Katharine, Madrigal, J. Alejandro, Maiers, Martin J., Malkki, Mari, McKallor, Caroline, Morishima, Yasuo, Oudshoorn, Machteld, Spellman, Stephen R., Villard, Jean, and Stevenson, Phil

Abstract

Background: The success of unrelated haemopoietic cell transplantation (HCT) is limited by graft-versus-host disease (GVHD), which is the main post-transplantation challenge when HLA-matched donors are unavailable. A sequence dimorphism in exon 1 of HLA-B gives rise to leader peptides containing methionine (Met; M) or threonine (Thr; T), which differentially influence natural killer and T-cell alloresponses. The main aim of the study was to evaluate the role of the leader dimorphism in GVHD after HLA-B-mismatched unrelated HCT. Methods: We did a retrospective cohort study of 33 982 patients who received an unrelated HCT done in Australia, Europe, japan, North America, and the UK between jan 1, 1988, and Dec 31, 2016. Data were contributed by participants of the International Histocompatibility Working Group in Hematopoietic Cell Transplantation. All cases were included and there were no exclusion criteria. Multivariate regression models were used to assess risks associated with HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 mismatching. Among the 33 982 transplantations, the risks of GVHD associated with HLA-B M and T leaders were established in 17 100 (50.3%) HLA-matched and 1457 (4.3%) single HLA-B-mismatched transplantations using multivariate regression models. Leader frequencies were defined in 2 004 742 BeTheMatch US registry donors. Findings: Between jan 20, 2017, and March 11, 2019, we assessed 33 982 HCTs using multivariate regression models for the role of HLA mismatching on outcome. Median follow-up was 1841 days (IQR 909-2963). Mortality and GVHD increased with increasing numbers of HLA mismatches. A single HLA-B mismatch increased grade 3-4 acute GVHD (odds ratio [OR] 1.89, 95% CI 1. 53-2.33; p<0.0001). Among the single HLA-B-mismatched transplantations, acute GVHD risk was higher with leader mismatching than with leader matching (OR 1.73, 1.02-2.94; p=0 .042 for grade 2-4) and with an M leader shared allotype compared with a T leader shared allotype (O

Published
2020
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41. Distinct contributions of cathelin‐related antimicrobial peptide ( CRAMP ) derived from epithelial cells and macrophages to colon mucosal homeostasis

Author

Chen, Keqiang, primary, Yoshimura, Teizo, additional, Yao, Xiaohong, additional, Gong, Wanghua, additional, Huang, Jiaqiang, additional, Dzutsev, Amiran K, additional, McCulloch, John, additional, O'hUigin, Colm, additional, Bian, Xiu‐wu, additional, Trinchieri, Giorgio, additional, and Wang, Ji Ming, additional

Published
2021
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43. A Prime/Boost Vaccine Regimen Alters the Rectal Microbiome and Impacts Immune Responses and Viremia Control Post-Simian Immunodeficiency Virus Infection in Male and Female Rhesus Macaques

Author

Musich, Thomas, primary, Thovarai, Vishal, additional, Venzon, David J., additional, Mohanram, Venkatramanan, additional, Tuero, Iskra, additional, Miller-Novak, Leia K., additional, Helmold Hait, Sabrina, additional, Rahman, Mohammad Arif, additional, Hunegnaw, Ruth, additional, Huiting, Erin, additional, Yuan, Wuxing, additional, O’hUigin, Colm, additional, Hoang, Tanya, additional, Sui, Yongjun, additional, LaBranche, Celia, additional, Montefiori, David, additional, Bear, Jenifer, additional, Rosati, Margherita, additional, Bissa, Massimiliano, additional, Berzofsky, Jay A., additional, Pavlakis, George N., additional, Felber, Barbara K., additional, Franchini, Genoveffa, additional, and Robert-Guroff, Marjorie, additional

Published
2020
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