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1. Optimising the diagnostic accuracy of First post-contrAst SubtracTed breast MRI (FAST MRI) through interpretation-training: a multicentre e-learning study, mapping the learning curve of NHS Breast Screening Programme (NHSBSP) mammogram readers using an enriched dataset

Author

Jones, Lyn I., Marshall, Andrea, Geach, Rebecca, Elangovan, Premkumar, O’Flynn, Elizabeth, Timlin, Tony, McKeown-Keegan, Sadie, Rose, Janice, Vinnicombe, Sarah, Taylor-Phillips, Sian, Halling-Brown, Mark, and Dunn, Janet A.

Published
2024
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5. Evaluating the effectiveness of abbreviated breast MRI (abMRI) interpretation training for mammogram readers: a multi-centre study assessing diagnostic performance, using an enriched dataset

Author

Jones, Lyn I., Marshall, Andrea, Elangovan, Premkumar, Geach, Rebecca, McKeown-Keegan, Sadie, Vinnicombe, Sarah, Harding, Sam A., Taylor-Phillips, Sian, Halling-Brown, Mark, Foy, Christopher, O’Flynn, Elizabeth, Ghiasvand, Hesam, Hulme, Claire, and Dunn, Janet A.

Published
2022
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7. Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions)

Author

Rageth, Christoph J., O’Flynn, Elizabeth A. M., Pinker, Katja, Kubik-Huch, Rahel A., Mundinger, Alexander, Decker, Thomas, Tausch, Christoph, Dammann, Florian, Baltzer, Pascal A., Fallenberg, Eva Maria, Foschini, Maria P., Dellas, Sophie, Knauer, Michael, Malhaire, Caroline, Sonnenschein, Martin, Boos, Andreas, Morris, Elisabeth, and Varga, Zsuzsanna

Published
2019
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8. The potential utility of abbreviated breast MRI (FAST MRI) as a tool for breast cancer screening: a systematic review and meta-analysis

Author

Kuhl, Christiane, Vinnicombe, Sarah, O'Flynn, Elizabeth, Wookey, Jennifer, Rose, Janice, Foy, Christopher, Taylor, Victoria, Valencia, Alexandra, Gifford, John, Gray, Rosie, Jones, Thomas William, Litton, Karen, Lloyd, Simon, Kutt, Elisabeth, Pocklington, Alice, Mahatma, Anjum, Massey, Helen, Clark, Gillian, McLachlan, Clare, Beckett, Gemini, Alison, Clare, Barta, Miklos, Betancourt, Claudia, Bramwell, Julie, Bright, Nichola, Burt, Helen, Cann, Louise, Ceney, Jane, Cornford, Eleanor, Dalgliesh, Diana, Doyle, Sarah, Fearn, Sarah, Godden, Dagmar, Goldthorpe, Zoe, Hobson, Lucinda, Hynam, Paula, Jackson, Emma, Jenkin, Margaret, Kingsnorth, Beckie, Klimczak, Katherine, Moody, Alice, Perrin, Sarah, Peters, Alison, Preston, Elizabeth, Ratsey, Anne, Sidebottom, Richard, Steel, Jim, Stephenson, Lesley, Taylor, Michelle, Toth, Erika, Vincent, Frances, Watkin, Sharon, Widdison, Sue, Williams, Jennifer, Wilmot, Karen, Elangovan, Premkumar, Halling-Brown, Mark, Ghiasvand, Hesam, Hulme, Claire, Singamaneni, Sravya, Friedrich, Zsolt, Robson, Joanne, Mankelow, Anna, Geach, R., Jones, L.I., Harding, S.A., Marshall, A., Taylor-Phillips, S., McKeown-Keegan, S., and Dunn, J.A.

Published
2021
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9. Breast Cancer

Author

O’Flynn, Elizabeth A. M., Luna, Antonio, editor, Vilanova, Joan C., editor, Hygino Da Cruz Jr., L. Celso, editor, and Rossi, Santiago E., editor

Published
2014
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10. Correction to: Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions)

Author

Rageth, Christoph J., O’Flynn, Elizabeth A. M., Pinker, Katja, Kubik-Huch, Rahel A., Mundinger, Alexander, Decker, Thomas, Tausch, Christoph, Dammann, Florian, Baltzer, Pascal A., Fallenberg, Eva Maria, Foschini, Maria P., Dellas, Sophie, Knauer, Michael, Malhaire, Caroline, Sonnenschein, Martin, Boos, Andreas, Morris, Elisabeth, and Varga, Zsuzsanna

Published
2019
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15. Evaluating the effectiveness of abbreviated breast MRI (abMRI) interpretation-training for mammogram-readers: a multicentre study assessing diagnostic performance, using an enriched dataset

Author

Jones, Lyn I, primary, Marshall, Andrea, additional, Elangovan, Premkumar, additional, Geach, Rebecca, additional, McKeown-Keegan, Sadie, additional, Vinnicombe, Sarah, additional, Harding, Sam A, additional, Taylor-Phillips, Sian, additional, Halling-Brown, Mark, additional, Foy, Christopher, additional, O’Flynn, Elizabeth, additional, Ghiasvand, Hesam, additional, Hulme, Claire, additional, and Dunn, Janet A, additional

Published
2022
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16. Additional file 1 of Evaluating the effectiveness of abbreviated breast MRI (abMRI) interpretation training for mammogram readers: a multi-centre study assessing diagnostic performance, using an enriched dataset

Author

Jones, Lyn I., Marshall, Andrea, Elangovan, Premkumar, Geach, Rebecca, McKeown-Keegan, Sadie, Vinnicombe, Sarah, Harding, Sam A., Taylor-Phillips, Sian, Halling-Brown, Mark, Foy, Christopher, O’Flynn, Elizabeth, Ghiasvand, Hesam, Hulme, Claire, and Dunn, Janet A.

Abstract

Additional file 1. Appendix 1: Specification of the abbreviated breast MRI (abMRI) protocol and composition of the FAST MRI test set used in the study. Appendix 2: Example of FAST MRI Study Day Agenda (identifiable information redacted for inclusion inblinded manuscript).

Published
2022
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19. Additional file 1 of 'Real-world' radiomics from multi-vendor MRI: an original retrospective study on the prediction of nodal status and disease survival in breast cancer, as an exemplar to promote discussion of the wider issues

Author

Doran, Simon J., Kumar, Santosh, Orton, Matthew, D’Arcy, James, Kwaks, Fenna, O’Flynn, Elizabeth, Ahmed, Zaki, Downey, Kate, Dowsett, Mitch, Turner, Nicholas, Messiou, Christina, and Dow-Mu Koh

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2021
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21. Abstract PS3-31: Training multi-professional mammogram readers to interpret abbreviated breast MRI (FAST MRI): A UK multi-centre study

Author

Jones, Lyn IL, primary, Geach, Rebecca, additional, Harding, Sam A, additional, Marshall, Andrea, additional, McKeown-Keegan, Sadie, additional, Taylor-Phillips, Sian, additional, Elangovan, Premkumar, additional, Halling-Brown, Mark, additional, Vinnicombe, Sarah, additional, O'Flynn, Elizabeth, additional, Ghiasvand, Hesam, additional, Hulme, Claire T, additional, and Dunn, Janet A, additional

Published
2021
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22. The potential utility of abbreviated breast MRI (FAST MRI) as a tool for breast cancer screening: a systematic review and meta-analysis

Author

Geach, R., primary, Jones, L.I., additional, Harding, S.A., additional, Marshall, A., additional, Taylor-Phillips, S., additional, McKeown-Keegan, S., additional, Dunn, J.A., additional, Kuhl, Christiane, additional, Vinnicombe, Sarah, additional, O'Flynn, Elizabeth, additional, Wookey, Jennifer, additional, Rose, Janice, additional, Foy, Christopher, additional, Taylor, Victoria, additional, Valencia, Alexandra, additional, Gifford, John, additional, Gray, Rosie, additional, Jones, Thomas William, additional, Litton, Karen, additional, Lloyd, Simon, additional, Kutt, Elisabeth, additional, Pocklington, Alice, additional, Mahatma, Anjum, additional, Massey, Helen, additional, Clark, Gillian, additional, McLachlan, Clare, additional, Beckett, Gemini, additional, Alison, Clare, additional, Barta, Miklos, additional, Betancourt, Claudia, additional, Bramwell, Julie, additional, Bright, Nichola, additional, Burt, Helen, additional, Cann, Louise, additional, Ceney, Jane, additional, Cornford, Eleanor, additional, Dalgliesh, Diana, additional, Doyle, Sarah, additional, Fearn, Sarah, additional, Godden, Dagmar, additional, Goldthorpe, Zoe, additional, Hobson, Lucinda, additional, Hynam, Paula, additional, Jackson, Emma, additional, Jenkin, Margaret, additional, Kingsnorth, Beckie, additional, Klimczak, Katherine, additional, Moody, Alice, additional, Perrin, Sarah, additional, Peters, Alison, additional, Preston, Elizabeth, additional, Ratsey, Anne, additional, Sidebottom, Richard, additional, Steel, Jim, additional, Stephenson, Lesley, additional, Taylor, Michelle, additional, Toth, Erika, additional, Vincent, Frances, additional, Watkin, Sharon, additional, Widdison, Sue, additional, Williams, Jennifer, additional, Wilmot, Karen, additional, Elangovan, Premkumar, additional, Halling-Brown, Mark, additional, Ghiasvand, Hesam, additional, Hulme, Claire, additional, Singamaneni, Sravya, additional, Friedrich, Zsolt, additional, Robson, Joanne, additional, and Mankelow, Anna, additional

Published
2021
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24. Quantitative evaluation of contrast agent uptake in standard fat‐suppressed dynamic contrast‐enhanced MRI examinations of the breast

Author

Kousi, Evanthia, Smith, Joely, Ledger, Araminta E., Scurr, Erica, Allen, Steven, Wilson, Robin M., O'Flynn, Elizabeth, Pope, Romney J.E., Leach, Martin O., and Schmidt, Maria A.

Subjects
Phantoms, Imaging, Carcinoma, Ductal, Breast, Contrast Media, Reproducibility of Results, Breast Neoplasms, calibration, Magnetic Resonance Imaging, quantification, Diagnosis, Differential, Carcinoma, Lobular, breast cancer, Adipose Tissue, QUANTITATIVE IMAGING AND IMAGE PROCESSING, Image Interpretation, Computer-Assisted, Feasibility Studies, Humans, Breast, skin and connective tissue diseases, Research Articles, DCE‐MRI, Parenchymal Tissue, Research Article
Abstract

Purpose To propose a method to quantify T1 and contrast agent uptake in breast dynamic contrast‐enhanced (DCE) examinations undertaken with standard clinical fat‐suppressed MRI sequences and to demonstrate the proposed approach by comparing the enhancement characteristics of lobular and ductal carcinomas. Methods A standard fat‐suppressed DCE of the breast was performed at 1.5 T (Siemens Aera), followed by the acquisition of a proton density (PD)‐weighted sequence, also fat suppressed. Both sequences were characterized with test objects (T1 ranging from 30 ms to 2,400 ms) and calibration curves were obtained to enable T1 calculation. The reproducibility and accuracy of the calibration curves were also investigated. Healthy volunteers and patients were scanned with Ethics Committee approval. The effect of B0 field inhomogeneity was assessed in test objects and healthy volunteers. The T1 of breast tumors was calculated at different time points (pre‐, peak‐, and post‐contrast agent administration) for 20 patients, pre‐treatment (10 lobular and 10 ductal carcinomas) and the two cancer types were compared (Wilcoxon rank‐sum test). Results The calibration curves proved to be highly reproducible (coefficient of variation under 10%). T1 measurements were affected by B0 field inhomogeneity, but frequency shifts below 50 Hz introduced only 3% change to fat‐suppressed T1 measurements of breast parenchyma in volunteers. The values of T1 measured pre‐, peak‐, and post‐contrast agent administration demonstrated that the dynamic range of the DCE sequence was correct, that is, image intensity is approximately directly proportional to 1/T1 for that range. Significant differences were identified in the width of the distributions of the post‐contrast T1 values between lobular and ductal carcinomas (P < 0.05); lobular carcinomas demonstrated a wider range of post‐contrast T1 values, potentially related to their infiltrative growth pattern. Conclusions This work has demonstrated the feasibility of fat‐suppressed T1 measurements as a tool for clinical studies. The proposed quantitative approach is practical, enabled the detection of differences between lobular and invasive ductal carcinomas, and further enables the optimization of DCE protocols by tailoring the dynamic range of the sequence to the values of T1 measured.

Published
2017

26. Ultrasound Tomography Evaluation of Breast Density

Author

O'Flynn, Elizabeth A.M., Fromageau, Jeremie, Ledger, Araminta E., Messa, Alessandro, D'Aquino, Ashley, Schoemaker, Minouk J., Schmidt, Maria, Duric, Neb, Swerdlow, Anthony J., and Bamber, Jeffrey C.

Subjects
Adult, Reproducibility of Results, Original Articles, Middle Aged, Magnetic Resonance Imaging, noncontrast Dixon MRI, Imaging, Three-Dimensional, ultrasound tomography, Humans, Female, Breast, Prospective Studies, Ultrasonography, Mammary, breast density, Tomography, Mammography
Abstract

Objectives Ultrasound tomography (UST) is an emerging whole-breast 3-dimensional imaging technique that obtains quantitative tomograms of speed of sound of the entire breast. The imaged parameter is the speed of sound which is used as a surrogate measure of density at each voxel and holds promise as a method to evaluate breast density without ionizing radiation. This study evaluated the technique of UST and compared whole-breast volume averaged speed of sound (VASS) with MR percent water content from noncontrast magnetic resonance imaging (MRI). Materials and Methods Forty-three healthy female volunteers (median age, 40 years; range, 29–59 years) underwent bilateral breast UST and MRI using a 2-point Dixon technique. Reproducibility of VASS was evaluated using Bland-Altman analysis. Volume averaged speed of sound and MR percent water were evaluated and compared using Pearson correlation coefficient. Results The mean ± standard deviation VASS measurement was 1463 ± 29 m s−1 (range, 1434–1542 m s−1). There was high similarity between right (1464 ± 30 m s−1) and left (1462 ± 28 m s−1) breasts (P = 0.113) (intraclass correlation coefficient, 0.98). Mean MR percent water content was 35.7% ± 14.7% (range, 13.2%–75.3%), with small but significant differences between right and left breasts (36.3% ± 14.9% and 35.1% ± 14.7%, respectively; P = 0.004). There was a very strong correlation between VASS and MR percent water density (r2 = 0.96, P < 0.0001). Conclusions Ultrasound tomography holds promise as a reliable and reproducible 3-dimensional technique to provide a surrogate measure of breast density and correlates strongly with MR percent water content.

Published
2017

28. Correction to: Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions)

Author

Rageth, Christoph J; https://orcid.org/0000-0001-9117-2825, O'Flynn, Elizabeth A M, Pinker, Katja, Kubik-Huch, Rahel A, Mundinger, Alexander, Decker, Thomas, Tausch, Christoph, Dammann, Florian, Baltzer, Pascal A, Fallenberg, Eva Maria, Foschini, Maria P, Dellas, Sophie, Knauer, Michael, Malhaire, Caroline, Sonnenschein, Martin, Boos, Andreas, Morris, Elisabeth, Varga, Zsuzsanna, Rageth, Christoph J; https://orcid.org/0000-0001-9117-2825, O'Flynn, Elizabeth A M, Pinker, Katja, Kubik-Huch, Rahel A, Mundinger, Alexander, Decker, Thomas, Tausch, Christoph, Dammann, Florian, Baltzer, Pascal A, Fallenberg, Eva Maria, Foschini, Maria P, Dellas, Sophie, Knauer, Michael, Malhaire, Caroline, Sonnenschein, Martin, Boos, Andreas, Morris, Elisabeth, and Varga, Zsuzsanna

Abstract

The article Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions), written by Christoph J Rageth, Elizabeth AM O'Flynn, Katja Pinker, Rahel A Kubik-Huch, Alexander Mundinger, Thomas Decker, Christoph Tausch, Florian Dammann, Pascal A. Baltzer, Eva Maria Fallenberg, Maria P Foschini, Sophie Dellas, Michael Knauer, Caroline Malhaire, Martin Sonnenschein, Andreas Boos, Elisabeth Morris, Zsuzsanna Varga, was originally published electronically on the publisher's internet portal (currently SpringerLink) on November 30, 2018 without open access.

Published
2019

29. Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions)

Author

Rageth, Christoph J; https://orcid.org/0000-0001-9117-2825, O’Flynn, Elizabeth A M, Pinker, Katja, Kubik-Huch, Rahel A, Mundinger, Alexander, Decker, Thomas, Tausch, Christoph, Dammann, Florian, Baltzer, Pascal A, Fallenberg, Eva Maria, Foschini, Maria P, Dellas, Sophie, Knauer, Michael, Malhaire, Caroline, Sonnenschein, Martin, Boos, Andreas, Morris, Elisabeth, Varga, Zsuzsanna, Rageth, Christoph J; https://orcid.org/0000-0001-9117-2825, O’Flynn, Elizabeth A M, Pinker, Katja, Kubik-Huch, Rahel A, Mundinger, Alexander, Decker, Thomas, Tausch, Christoph, Dammann, Florian, Baltzer, Pascal A, Fallenberg, Eva Maria, Foschini, Maria P, Dellas, Sophie, Knauer, Michael, Malhaire, Caroline, Sonnenschein, Martin, Boos, Andreas, Morris, Elisabeth, and Varga, Zsuzsanna

Abstract

Purpose The second International Consensus Conference on B3 lesions was held in Zurich, Switzerland, in March 2018, organized by the International Breast Ultrasound School to re-evaluate the consensus recommendations. Methods This study (1) evaluated how management recommendations of the first Zurich Consensus Conference of 2016 on B3 lesions had influenced daily practice and (2) reviewed current literature towards recommendations to biopsy. Results In 2018, the consensus recommendations for management of B3 lesions remained almost unchanged: For flat epithelial atypia (FEA), classical lobular neoplasia (LN), papillary lesions (PL) and radial scars (RS) diagnosed on core-needle biopsy (CNB) or vacuum-assisted biopsy (VAB), excision by VAB in preference to open surgery, and for atypical ductal hyperplasia (ADH) and phyllodes tumors (PT) diagnosed at VAB or CNB, first-line open surgical excision (OE) with follow-up surveillance imaging for 5 years. Analyzing the Database of the Swiss Minimally Invasive Breast Biopsies (MIBB) with more than 30,000 procedures recorded, there was a significant increase in recommending more frequent surveillance of LN [65% in 2018 vs. 51% in 2016 (p = 0.004)], FEA (72% in 2018 vs. 62% in 2016 (p = 0.005)), and PL [(76% in 2018 vs. 70% in 2016 (p = 0.04)] diagnosed on VAB. A trend to more frequent surveillance was also noted also for RS [77% in 2018 vs. 67% in 2016 (p = 0.07)]. Conclusions Minimally invasive management of B3 lesions (except ADH and PT) with VAB continues to be appropriate as an alternative to first-line OE in most cases, but with more frequent surveillance, especially for LN.

Published
2019

30. Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions)

Author

Rageth, Christoph J., primary, O’Flynn, Elizabeth A. M., additional, Pinker, Katja, additional, Kubik-Huch, Rahel A., additional, Mundinger, Alexander, additional, Decker, Thomas, additional, Tausch, Christoph, additional, Dammann, Florian, additional, Baltzer, Pascal A., additional, Fallenberg, Eva Maria, additional, Foschini, Maria P., additional, Dellas, Sophie, additional, Knauer, Michael, additional, Malhaire, Caroline, additional, Sonnenschein, Martin, additional, Boos, Andreas, additional, Morris, Elisabeth, additional, and Varga, Zsuzsanna, additional

Published
2018
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32. Multi-parametric MRI in the early prediction of response to neo-adjuvant chemotherapy in breast cancer: Value of non-modelled parameters.

Author

O’Flynn, Elizabeth AM, Collins, David, D’Arcy, James, Schmidt, Maria, de Souza, Nandita M, O'Flynn, Elizabeth Am, D'Arcy, James, and O'Flynn, Elizabeth A M

Subjects
*BREAST cancer magnetic resonance imaging, *CANCER chemotherapy, *ADJUVANT treatment of cancer, *FUNCTIONAL magnetic resonance imaging, *POLYMERASE chain reaction, *RECEIVER operating characteristic curves
Abstract

Objective: To prospectively evaluate individual functional MRI metrics for the early prediction of pathological complete response (pCR) to neo-adjuvant chemotherapy (NAC) in breast cancer. Materials and Methods: Thirty-two women (median age 52 years; range 32-71 years) with biopsy proven breast cancer due to receive neo-adjuvant anthracycline and/or taxane-based chemotherapy were prospectively recruited following local research ethics committee approval and written informed consent. Breast MRI was performed prior to and after two cycles of NAC and pCR was assessed after surgery. The enhancement fraction (EF), tumour volume, initial area under the gadolinium curve (IAUGC), pharmacokinetic parameters (K(trans), kep and ve), the apparent diffusion coefficient (ADC) and R2* values, along with the percentage change in these parameters after two cycles were evaluated according to pCR status using an independent samples t-test. The area under the receiver operating characteristics curve (AUC) was calculated for each parameter. Linear discriminant analysis (LDA) determined the most important parameter in predicting pCR. Results: A reduction in the EF (-41% ± 38%) and tumour volume (-80% ± 25%) after 2 cycles of NAC were significantly greater in those achieving pCR (p=0.025, p=0.011 respectively). A reduction in the EF of 7% after 2 cycles of NAC identified those more likely to achieve pCR (AUC 0.76). AUC changes in other parameters were tumour volume (0.77), IAUGC (0.64), K(trans) (0.60), kep (0.68), ve (0.58), ADC (0.69) and R2* (0.41). Conclusion: In a multi-parametric MRI model, the decrease in a non-model based vascular parameter the enhancement fraction as well as the tumour volume are the most important early predictors of pCR in breast cancer. [ABSTRACT FROM AUTHOR]

Published
2016
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33. British Society of Breast Radiology Annual Scientific Meeting 2016

Author

Azmil, Ameerah Mohd, primary, Bansal, Gaurav Jyoti, additional, Davies, Eleri, additional, Wallis, Matthew, additional, Kilburn-Toppin, Fleur, additional, Taylor-Phillip, Sian, additional, Buckley, Anne, additional, Healy, Nuala, additional, Quinn, Aine, additional, O’Keeffe, Sylvia, additional, Ang, Teri, additional, Maxwell, Anthony, additional, Lim, Yit Y., additional, Harkness, Elaine, additional, Emsley, Richard, additional, Astley, Susan, additional, Gadde, Soujanya, additional, Ferguson, Jennifer, additional, Stevens, Guy, additional, Hills, Robert, additional, Thomas, Kate Gower, additional, Rajan, Sabrina, additional, Sharma, Nisha, additional, Kishore, Ajit, additional, O’ Dowd, John, additional, Murphy, Claire, additional, Lindsay, Ken, additional, Dadayal, Guneesh, additional, Moody, Anne Nielsen, additional, Whitaker, Madeleine, additional, Wolstenhulme, Stephen, additional, Bull, Jane, additional, Culpan, Anne-Marie, additional, Roszkowski, Natalia, additional, Grima, Alexis, additional, Stahnke, Michaela, additional, Rubin, Caroline, additional, Walker, Ruth, additional, Oeppen, Rachel, additional, Puttagunta, Srikanth, additional, Gray, Karen, additional, Puri, Shama, additional, Millican-Slater, Rebecca, additional, Pascaline, Sana, additional, Hajaj, Mohamad, additional, Flinn, Janet, additional, Thomson, Kim, additional, Elsberger, Beatrix, additional, Turnbull, Anne, additional, Bagnall, Mark, additional, York, Joanne, additional, Benney, Stuart, additional, Goyal, Amit, additional, Topps, Ashley, additional, Barr, Simon, additional, Pikoulas, Panagiotis, additional, Pritchard, Susan, additional, Greenhalgh, Sophie, additional, Sreenivas, Muthyala, additional, Nandhra, Anju, additional, Sharma, Sheetal, additional, Gulati, Archita, additional, Razzaq, Furhan, additional, Khan, Sana, additional, McKillen, Jacqueline, additional, Larkin, Rupert, additional, Kamat, Sachin, additional, Goncalves, Carla, additional, Tan, Alan, additional, Eleti, Asha, additional, Vidyaprakash, Nithya, additional, McMahon, Michelle A., additional, Dall, Barbara J. G., additional, Majid, Faisal, additional, Rattehalli, Ramachadra, additional, Gaur, Vandana, additional, Mackenzie, Alistair, additional, Warren, Lucy, additional, Patel, Mishal, additional, Halling-Brown, Mark, additional, Wilkinson, Louise, additional, Young, Kenneth, additional, Tanner, James, additional, Currie, Rachael, additional, Balyes, Sharron, additional, Wragg, Julie, additional, Zamfir, Georgiana, additional, Ayra, Pallavi, additional, Marsden, Max, additional, Butterworth, James, additional, Sinha, Shona, additional, Desai, Anil, additional, Metafa, Anna, additional, Nielsen-Moody, Anne, additional, Ward, Laura, additional, Heller, Samantha, additional, Hudson, Sue, additional, Taylor, Kathryn, additional, Xyda, Argyro, additional, Allen, Steven, additional, Orlowski, Elizabeth, additional, Downey, Kate, additional, Sidebottom, Richard, additional, Lodhi, Ahmad, additional, Howell, Anthony, additional, Evans, Gareth, additional, Lim, Yit, additional, Chen, Yan, additional, Lepine-Williams, Elizabeth, additional, Henderson, Steven, additional, Litherland, Janet, additional, Altaf, Naveed, additional, Bury, Yvonne, additional, Forester, Nerys, additional, Chin, Mei Chan, additional, Taylor, Caroline, additional, Skippage, Pippa, additional, Sian, Aneet, additional, McAvinchey, Rita, additional, Evans, Tom, additional, Nisbet, Sian, additional, Murray, Alex, additional, Castillo, Raquel Clark, additional, Markham, Hannah, additional, Thomas, Timothy, additional, Jain, Anil, additional, Molderson, Jaanilka, additional, Wan, Joseph, additional, Newman, Helen, additional, Lowes, Simon, additional, Lunt, Linsley, additional, Sultana, Sadia, additional, Chillal, Varun, additional, Dalton, Rebecca, additional, Reeves, David, additional, Sergeant, Jamie, additional, Edwards, Liz, additional, Jenkins, Kate, additional, Shaikh, Shaheeda, additional, O’Flynn, Elizabeth, additional, Bombroffe, Laura, additional, Hughes, Julie, additional, Scurr, Erica, additional, Wilson, Robin, additional, Jones, Lyn, additional, Govindarajulu, Sasirekha, additional, Sahu, Ajay K., additional, Brown, Matthew, additional, Allen, Steve, additional, O’Flynn, Liz, additional, deSouza, Nandita, additional, Rahim, Rumana, additional, Wasan, Rema, additional, Goligher, Jane, additional, Wijesuriya, Shalini, additional, Morel, Juliet, additional, Peacock, Clare, additional, Michell, Michael, additional, Iqbal, Asif, additional, Evans, David, additional, Batohi, Bhavna, additional, Wasan, Tavleen, additional, Phillips, Vivien, additional, Manuel, Eden, additional, Bowman, Gillian, additional, Satchithananda, Keshthra, additional, Fang, Cheng, additional, Shah, Chirag, additional, Hodkin, Leanne, additional, Horgan, Keiran, additional, Dodwell, David, additional, Moloney, BM, additional, Casey, M. C., additional, Breathnach, A., additional, Dwyer, R. M., additional, McLoughlin, R., additional, Sweeney, K. J., additional, Malone, C., additional, Healy, M. J., additional, Kerin, M. J., additional, Mitchell, Elizabeth, additional, Twiddy, Maureen, additional, Dobson, Hilary, additional, Vinnicombe, Sarah, additional, Evans, Andrew, additional, Grant, David, additional, Bishop, Briony, additional, Giggens, Roxanne, additional, Bhuva, Shaheel, additional, Royds, Jennifer, additional, Camilleri, Francesca, additional, Babu, Gauripriya, additional, Beveridge, Carolyn, additional, Geach, Rebecca, additional, Klimczak, Katherine, additional, Massey, Helen, additional, Lyburn, Iain, additional, Salehi-Bird, Seema, additional, Nishtala, Sahithi, additional, Gunning, Liz, additional, Changaradil, Deepthi Vinayan, additional, Bansal, Jyoti, additional, Davis, Joanna, additional, Sharma, Ashwini, additional, Del Voscovo, Elena, additional, Etheridge, Harriet, additional, Butler, Aisling, additional, Fenne, David S. J., additional, Rubin, Gary, additional, Burt, Helen, additional, Ridley, Nick, additional, Taylor, Sarah, additional, Seth, Subodh, additional, and Seth, Archana, additional

Published
2016
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36. Evaluation of diffusion models in breast cancer

Author

Panek, Rafal, primary, Borri, Marco, additional, Orton, Matthew, additional, O'Flynn, Elizabeth, additional, Morgan, Veronica, additional, Giles, Sharon L., additional, deSouza, Nandita, additional, Leach, Martin O., additional, and Schmidt, Maria A., additional

Published
2015
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38. Quantitative evaluation of contrast agent uptake in standard fat‐suppressed dynamic contrast‐enhanced MRI examinations of the breast.

Author

Kousi, Evanthia, Smith, Joely, Ledger, Araminta E., Scurr, Erica, Allen, Steven, Wilson, Robin M., O'Flynn, Elizabeth, Pope, Romney J. E., Leach, Martin O., and Schmidt, Maria A.

Subjects
MAGNETIC resonance mammography, CONTRAST media, LOBULAR carcinoma, DUCTAL carcinoma, PROTON therapy
Abstract

Purpose: To propose a method to quantify T1 and contrast agent uptake in breast dynamic contrast‐enhanced (DCE) examinations undertaken with standard clinical fat‐suppressed MRI sequences and to demonstrate the proposed approach by comparing the enhancement characteristics of lobular and ductal carcinomas. Methods: A standard fat‐suppressed DCE of the breast was performed at 1.5 T (Siemens Aera), followed by the acquisition of a proton density (PD)‐weighted sequence, also fat suppressed. Both sequences were characterized with test objects (T1 ranging from 30 ms to 2,400 ms) and calibration curves were obtained to enable T1 calculation. The reproducibility and accuracy of the calibration curves were also investigated. Healthy volunteers and patients were scanned with Ethics Committee approval. The effect of B0 field inhomogeneity was assessed in test objects and healthy volunteers. The T1 of breast tumors was calculated at different time points (pre‐, peak‐, and post‐contrast agent administration) for 20 patients, pre‐treatment (10 lobular and 10 ductal carcinomas) and the two cancer types were compared (Wilcoxon rank‐sum test). Results: The calibration curves proved to be highly reproducible (coefficient of variation under 10%). T1 measurements were affected by B0 field inhomogeneity, but frequency shifts below 50 Hz introduced only 3% change to fat‐suppressed T1 measurements of breast parenchyma in volunteers. The values of T1 measured pre‐, peak‐, and post‐contrast agent administration demonstrated that the dynamic range of the DCE sequence was correct, that is, image intensity is approximately directly proportional to 1/T1 for that range. Significant differences were identified in the width of the distributions of the post‐contrast T1 values between lobular and ductal carcinomas (P < 0.05); lobular carcinomas demonstrated a wider range of post‐contrast T1 values, potentially related to their infiltrative growth pattern. Conclusions: This work has demonstrated the feasibility of fat‐suppressed T1 measurements as a tool for clinical studies. The proposed quantitative approach is practical, enabled the detection of differences between lobular and invasive ductal carcinomas, and further enables the optimization of DCE protocols by tailoring the dynamic range of the sequence to the values of T1 measured. [ABSTRACT FROM AUTHOR]

Published
2018
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40. Initial experience of the BREAST-Q breast-conserving therapy module.

Author

O'Connell, Rachel, DiMicco, Rosa, Khabra, Komel, O'Flynn, Elizabeth, deSouza, Nandita, Roche, Nicola, Barry, Peter, Kirby, Anna, and Rusby, Jennifer

Abstract

Purpose: The most recently developed module of the BREAST-Q, a validated patient outcome measure, is for patients who have undergone breast-conserving therapy (BCT) for cancer. This aim of this study was to assess patient satisfaction and quality of life after BCT using BREAST-Q, investigate clinical risk factors for lower satisfaction and explore the relationship between patient satisfaction with the appearance of their breasts and the other domains of the BREAST-Q. Methods: Women who had undergone unilateral BCT in the preceding 1-6 years were invited to participate at the time of their annual surveillance mammogram. Clinicopathological data were collected from an electronic database. Linear regression was used to evaluate risk factors for lower satisfaction. Spearman's rho correlation coefficients were calculated to evaluate the relationship between domains. Results: 200 women completed the questionnaire. Mean age was 60 years (SD 11.1). Time from surgery was 35.5 months (SD 17.8). Median score for 'Satisfaction with breasts' was 68 (interquartile range 55-80). Lowest scores were for 'sexual wellbeing' (57, IQR 45-66). On multivariate analysis, BMI at the time of surgery ( p = 0.002), delayed wound healing ( p = 0.001) and axillary surgery ( p = 0.003) were independent risk factors for lower satisfaction. There was significant correlation between 'Satisfaction with breasts' and all other BREAST-Q domains. Conclusion: High BMI, delayed wound healing and axillary surgery are risk factors for lower patient satisfaction. This first publication reporting the whole dataset for the BREAST-Q BCT will serve as a benchmark for future studies of patient satisfaction following BCT. [ABSTRACT FROM AUTHOR]

Published
2016
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