202 results on '"O'Dwyer, Laurence"'
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2. Atlanta, Vanessaa Talanta (Linnaeus, 1758), and: Blanca De L'Arç, Aporia Crataegi (Linnaeus, 1758), and: Arlequí, Zerynthia Rumina (Linnaeus, 1758), and: Angelet, Leptidea Sinapis (Linnaeus, 1758)
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O'Dwyer, Laurence
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- 2021
3. Piedra De Sol
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O'Dwyer, Laurence
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- 2021
4. The Girl with the Shovel, and: Counter-Tiller
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O'dwyer, Laurence
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- 2020
5. The European Innovation Network as a hub for medicines innovation in Europe
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Agricola, Eleonora, Auriche-Benichou, Caroline, Baiao, Helena, Blanquie, Oriane, Bodea, Teodora, Boráň, Tomáš, Borg, John-Joseph, Cordo’, Valentina, Di Marzo, Maria, Dmowski Rugholm, Lars, Ehmann, Falk, Hauksdóttir Hvannberg, Rúna, Herold, Ralf, Irs, Alar, Jurkovič Mlakar, Simona, Klaus, Robert, Kolehmainen, Juha, Lahorte, Christophe, Löbker, Wiebke, Mäkinen Salmi, Anna, Nuevo Ordoñez, Yoana, O’Dwyer, Laurence, Pasmooij, Anna Maria Gerdina, Saeterdal, Ingvil, Spakova, Bronislava, Starokozhko, Viktoriia, Ziegele, Bettina, and Zywiec, Katarzyna
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- 2024
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6. Differences in Intrinsic Gray Matter Connectivity and Their Genomic Underpinnings in Autism Spectrum Disorder
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Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian F., Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Buitelaar, Jan K., Chakrabarti, Bhismadev, Charman, Tony, Cornelissen, Ineke, Crawley, Daisy, Dell’Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary, Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng-Chuan, D’ardhuy, Xavier Liogier, Lombardo, Michael V., Loth, Eva, Lythgoe, David J., Mandl, René, Marquand, Andre, Mason, Luke, Mennes, Maarten, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Bast, Nico, Murphy, Declan G.M., Oakley, Bethany, O’Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, San José Cáceres, Antonia, Simonoff, Emily, Spooren, Will, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, Zwiers, Marcel P., Leyhausen, Johanna, Schäfer, Tim, Gurr, Caroline, Berg, Lisa M., Seelemeyer, Hanna, Pretzsch, Charlotte M., Floris, Dorothea L., Chatham, Chris, and Murphy, Declan G.
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- 2024
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7. Autism Is Associated With Interindividual Variations of Gray and White Matter Morphology
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Buitelaar, Jan K., Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian F., Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Chakrabarti, Bhismadev, Charman, Tony, Cornelissen, Ineke, Crawley, Daisy, Dell’Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary, Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng-Chuan, Liogier d’Ardhuy, Xavier, Lombardo, Michael V., Loth, Eva, Lythgoe, David J., Mandl, René, Marquand, Andre, Mason, Luke, Mennes, Maarten, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, Murphy, Declan G.M., Oakley, Bethany, O’Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Rausch, Annika, Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, San José Cáceres, Antonia, Simonoff, Emily, Spooren, Will, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, Ilioska, Iva, Mei, Ting, Zwiers, Marcel P., Forde, Natalie J., Floris, Dorothea L., Stones, Richard, Holt, Rosemary J., and Llera, Alberto
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- 2023
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8. Strategic recommendations from the STARS project to foster academic drug development
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Starokozhko, Viktoriia, Heß, Anne, Löbker, Wiebke, Ballensiefen, Wolfgang, Agricola, Eleonora, Ziegele, Bettina, Kallio, Marko J., O’Dwyer, Laurence, Nuevo, Yoana, Mol, Peter G. M., and Pasmooij, Anna M. G.
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- 2023
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9. Temporal Profiles of Social Attention Are Different Across Development in Autistic and Neurotypical People
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Ahmad, Jumana, Ambrosino, Sara, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian F., Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Cornelissen, Ineke, Crawley, Daisy, Dell’Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hipp, Joerg, Holt, Rosemary, Lai, Meng-Chuan, D’Ardhuy, Xavier Liogier, Lombardo, Michael V., Lythgoe, David J., Mandl, René, Marquand, Andre, Mennes, Maarten, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, Murphy, Declan G.M., Oakley, Bethany, O’Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, San José Cáceres, Antonia, Simonoff, Emily, Spooren, Will, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, Zwiers, Marcel P., Del Bianco, Teresa, Mason, Luke, Charman, Tony, Tillman, Julian, Loth, Eva, Hayward, Hannah, Shic, Frederick, Buitelaar, Jan, Johnson, Mark H., and Jones, Emily J.H.
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- 2021
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10. Atypical Brain Asymmetry in Autism—A Candidate for Clinically Meaningful Stratification
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Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian F., Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Buitelaar, Jan K., Chakrabarti, Bhismadev, Charman, Tony, Cornelissen, Ineke, Crawley, Daisy, Dell’Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary, Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng-Chuan, Liogier d’Ardhuy, Xavier, Lombardo, Michael V., Loth, Eva, Lythgoe, David J., Mandl, René, Marquand, Andre, Mason, Luke, Mennes, Maarten, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, Murphy, Declan G.M., Oakley, Bethany, O’Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, San José Cáceres, Antonia, Simonoff, Emily, Spooren, Will, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, Zwiers, Marcel P., Floris, Dorothea L., Wolfers, Thomas, Zabihi, Mariam, and Holz, Nathalie E.
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- 2021
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11. Differences in Intrinsic Gray Matter Connectivity and Their Genomic Underpinnings in Autism Spectrum Disorder
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Leyhausen, Johanna, primary, Schäfer, Tim, additional, Gurr, Caroline, additional, Berg, Lisa M., additional, Seelemeyer, Hanna, additional, Pretzsch, Charlotte M., additional, Loth, Eva, additional, Oakley, Bethany, additional, Buitelaar, Jan K., additional, Beckmann, Christian F., additional, Floris, Dorothea L., additional, Charman, Tony, additional, Bourgeron, Thomas, additional, Banaschewski, Tobias, additional, Jones, Emily J.H., additional, Tillmann, Julian, additional, Chatham, Chris, additional, Murphy, Declan G., additional, Ecker, Christine, additional, Ahmad, Jumana, additional, Ambrosino, Sara, additional, Auyeung, Bonnie, additional, Baron-Cohen, Simon, additional, Baumeister, Sarah, additional, Bölte, Sven, additional, Bours, Carsten, additional, Brammer, Michael, additional, Brandeis, Daniel, additional, Brogna, Claudia, additional, de Bruijn, Yvette, additional, Chakrabarti, Bhismadev, additional, Cornelissen, Ineke, additional, Crawley, Daisy, additional, Dell’Acqua, Flavio, additional, Dumas, Guillaume, additional, Durston, Sarah, additional, Faulkner, Jessica, additional, Frouin, Vincent, additional, Garcés, Pilar, additional, Goyard, David, additional, Ham, Lindsay, additional, Hayward, Hannah, additional, Hipp, Joerg, additional, Holt, Rosemary, additional, Johnson, Mark H., additional, Kundu, Prantik, additional, Lai, Meng-Chuan, additional, D’ardhuy, Xavier Liogier, additional, Lombardo, Michael V., additional, Lythgoe, David J., additional, Mandl, René, additional, Marquand, Andre, additional, Mason, Luke, additional, Mennes, Maarten, additional, Meyer-Lindenberg, Andreas, additional, Moessnang, Carolin, additional, Bast, Nico, additional, Murphy, Declan G.M., additional, O’Dwyer, Laurence, additional, Oldehinkel, Marianne, additional, Oranje, Bob, additional, Pandina, Gahan, additional, Persico, Antonio M., additional, Ruggeri, Barbara, additional, Ruigrok, Amber, additional, Sabet, Jessica, additional, Sacco, Roberto, additional, San José Cáceres, Antonia, additional, Simonoff, Emily, additional, Spooren, Will, additional, Toro, Roberto, additional, Tost, Heike, additional, Waldman, Jack, additional, Williams, Steve C.R., additional, Wooldridge, Caroline, additional, and Zwiers, Marcel P., additional
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- 2024
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12. MINKE WHALE
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O'Dwyer, Laurence
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- 2018
13. Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project
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Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian F., Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Buitelaar, Jan K., Chakrabarti, Bhismadev, Charman, Tony, Cornelissen, Ineke, Crawley, Daisy, Dell’Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary, Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng-Chuan, Liogier D’ardhuy, Xavier, Lombardo, Michael V., Loth, Eva, Lythgoe, David J., Mandl, René, Marquand, Andre, Mason, Luke, Mennes, Maarten, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, Murphy, Declan G.M., Oakley, Bethany, O’Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Spooren, Will, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, and Zwiers, Marcel P.
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- 2019
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14. Therapeutic genome editing: regulatory horizons
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Hines, Philip A., Agricola, Eleonora, Llinares Garcia, Jordi, O’Dwyer, Laurence, and Herold, Ralf
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- 2022
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15. Diffusion-MRI in neurodegenerative disorders
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Goveas, Joseph, O’Dwyer, Laurence, Mascalchi, Mario, Cosottini, Mirco, Diciotti, Stefano, De Santis, Silvia, Passamonti, Luca, Tessa, Carlo, Toschi, Nicola, and Giannelli, Marco
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- 2015
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16. Autism Is Associated With Interindividual Variations of Gray and White Matter Morphology
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Mei, Ting, primary, Forde, Natalie J., additional, Floris, Dorothea L., additional, Dell’Acqua, Flavio, additional, Stones, Richard, additional, Ilioska, Iva, additional, Durston, Sarah, additional, Moessnang, Carolin, additional, Banaschewski, Tobias, additional, Holt, Rosemary J., additional, Baron-Cohen, Simon, additional, Rausch, Annika, additional, Loth, Eva, additional, Oakley, Bethany, additional, Charman, Tony, additional, Ecker, Christine, additional, Murphy, Declan G.M., additional, Beckmann, Christian F., additional, Llera, Alberto, additional, Buitelaar, Jan K., additional, Ahmad, Jumana, additional, Ambrosino, Sara, additional, Auyeung, Bonnie, additional, Baumeister, Sarah, additional, Bölte, Sven, additional, Bourgeron, Thomas, additional, Bours, Carsten, additional, Brammer, Michael, additional, Brandeis, Daniel, additional, Brogna, Claudia, additional, de Bruijn, Yvette, additional, Chakrabarti, Bhismadev, additional, Cornelissen, Ineke, additional, Crawley, Daisy, additional, Dumas, Guillaume, additional, Faulkner, Jessica, additional, Frouin, Vincent, additional, Garcés, Pilar, additional, Goyard, David, additional, Ham, Lindsay, additional, Hayward, Hannah, additional, Hipp, Joerg, additional, Holt, Rosemary, additional, Johnson, Mark H., additional, Jones, Emily J.H., additional, Kundu, Prantik, additional, Lai, Meng-Chuan, additional, Liogier d’Ardhuy, Xavier, additional, Lombardo, Michael V., additional, Lythgoe, David J., additional, Mandl, René, additional, Marquand, Andre, additional, Mason, Luke, additional, Mennes, Maarten, additional, Meyer-Lindenberg, Andreas, additional, Mueller, Nico, additional, O’Dwyer, Laurence, additional, Oldehinkel, Marianne, additional, Oranje, Bob, additional, Pandina, Gahan, additional, Persico, Antonio M., additional, Ruggeri, Barbara, additional, Ruigrok, Amber, additional, Sabet, Jessica, additional, Sacco, Roberto, additional, San José Cáceres, Antonia, additional, Simonoff, Emily, additional, Spooren, Will, additional, Tillmann, Julian, additional, Toro, Roberto, additional, Tost, Heike, additional, Waldman, Jack, additional, Williams, Steve C.R., additional, Wooldridge, Caroline, additional, Mei, Ting, additional, and Zwiers, Marcel P., additional
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- 2022
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17. Voxel-based morphometry analysis reveals frontal brain differences in participants with ADHD and their unaffected siblings
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Bralten, Janita, Greven, Corina U., Franke, Barbara, Mennes, Maarten, Zwiers, Marcel P., Rommelse, Nanda N.J., Hartman, Catharina, van der Meer, Dennis, O'Dwyer, Laurence, Oosterlaan, Jaap, Hoekstra, Pieter J., Heslenfeld, Dirk, Arias-Vasquez, Alejandro, and Buitelaar, Jan K.
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Attention deficit hyperactivity disorder -- Physiological aspects ,Morphometrics (Biology) -- Methods ,Health ,Psychology and mental health - Abstract
Background: Data on structural brain alterations in patients with attention-deficit/hyperactivity disorder (ADHD) have been inconsistent. Both ADHD and brain volumes have a strong genetic loading, but whether brain alterations in patients with ADHD are familial has been underexplored. We aimed to detect structural brain alterations in adolescents and young adults with ADHD compared with healthy controls. We examined whether these alterations were also found in their unaffected siblings, using a uniquely large sample. Methods: We performed voxelbased morphometry analyses on MRI scans of patients with ADHD, their unaffected siblings and typically developing controls. We identified brain areas that differed between participants with ADHD and controls and investigated whether these areas were different in unaffected siblings. Influences of medication use, age, sex and IQ were considered. Results: Our sample included 307 patients with ADHD, 169 unaffected siblings and 196 typically developing controls (mean age 17.2 [range 8-30] yr). Compared with controls, participants with ADHD had significantly smaller grey matter volume in 5 clusters located in the precentral gyrus, medial and orbitofrontal cortex, and (para)cingulate cortices. Unaffected siblings showed intermediate volumes significantly different from controls in 4 of these clusters (all except the precentral gyrus). Medication use, age, sex and IQ did not have an undue influence on the results. Limitations: Our sample was heterogeneous, most participants with ADHD were taking medication, and the comparison was cross-sectional. Conclusion: Brain areas involved in decision making, motivation, cognitive control and motor functioning were smaller in participants with ADHD than in controls. Investigation of unaffected siblings indicated familiality of 4 of the structural brain differences, supporting their potential in molecular genetic analyses in ADHD research., Introduction Attention-deficit/hyperactivity disorder (ADHD) is a common neuropsychiatric disorder characterized by developmentally inappropriate impulsive, hyperactive and/or inattentive symptoms. (1) Previous MRI studies have reported smaller total brain volumes in participants [...]
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- 2016
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18. Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis
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Garcés, Pilar, Baumeister, Sarah, Mason, Luke, Chatham, Christopher, Holiga, Stefan, Dukart, Juergen, Jones, Emily, Banaschewski, Tobias, Baron-Cohen, Simon, Bölte, Sven, Buitelaar, Jan, Durston, Sarah, Oranje, Bob, Persico, Antonio, Beckmann, Christian, Bougeron, Thomas, Dell’acqua, Flavio, Ecker, Christine, Moessnang, Carolin, Charman, Tony, Tillmann, Julian, Murphy, Declan, Johnson, Mark, Loth, Eva, Brandeis, Daniel, Hipp, Joerg, Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brogna, Claudia, de Bruijn, Yvette, Chakrabarti, Bhismadev, Cornelissen, Ineke, Crawley, Daisy, Dumas, Guillaume, Faulkner, Jessica, Frouin, Vincent, Goyard, David, Ham, Lindsay, Hayward, Hannah, Holt, Rosemary, Kundu, Prantik, Lai, Meng-Chuan, Ardhuy, Xavier Liogier D’, Lombardo, Michael, Lythgoe, David, Mandl, René, Marquand, Andre, Mennes, Maarten, Meyer-Lindenberg, Andreas, Mueller, Nico, Oakley, Bethany, O’dwyer, Laurence, Oldehinkel, Marianne, Pandina, Gahan, Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Spooren, Will, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve, Wooldridge, Caroline, Zwiers, Marcel, Leap Group, The Eu-Aims, Garcés, Pilar [0000-0003-4989-0123], Apollo - University of Cambridge Repository, Roche Innovation Center [Basel, Switzerland], Heidelberg University, University Hospital Mannheim | Universitätsmedizin Mannheim, University of London [London], Institute of Neuroscience and Medicine, Brain and Behaviour [Jülich, Germany] (INM-7), Jülich Research Centre, Autism Research Centre [Cambridge, Royaume-Uni], University of Cambridge [UK] (CAM), Centre for Psychiatry Research [Stockholm], Karolinska Institutet [Stockholm], Curtin University [Perth], Planning and Transport Research Centre (PATREC), Donders Institute for Brain, Cognition and Behaviour, Radboud University [Nijmegen], University Medical Center [Utrecht], Università degli Studi di Messina = University of Messina (UniMe), Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), King‘s College London, Goethe-University Frankfurt am Main, Central Institute of Mental Health [Mannheim], This work was supported by EU-AIMS (European Autism Interventions), which receives support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115300, the resources of which are composed of financial contributions from the European Union’s Seventh Framework Programme (grant FP7/2007–2013), from the European Federation of Pharmaceutical Industries and Associations companies’ in-kind contributions and from Autism Speaks. AIMS-2-TRIALS is funded by the Innovative Medicines Initiative 2 Joint Undertaking (IMI 2 JU) under grant agreement no. 777394. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation program, EFPIA, Autism Speaks, Autistica, and SFARI. PG was supported by the Roche Postdoctoral Fellowship (RPF) program., European Project: 115300,EC:FP7:SP1-JTI,IMI-JU-03-2010,EU-AIMS(2012), European Project: 777394,H2020-JTI-IMI2-2016-10-two-stage,AIMS-2-TRIALS(2018), and University of Zurich
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Adult ,Adolescent ,Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] ,Autism spectrum disorder ,EEG ,Resting state ,Power spectrum ,Functional connectivity ,610 Medicine & health ,1309 Developmental Biology ,2806 Developmental Neuroscience ,2738 Psychiatry and Mental Health ,Developmental Neuroscience ,130 000 Cognitive Neurology & Memory ,1312 Molecular Biology ,Humans ,ddc:610 ,10064 Neuroscience Center Zurich ,Autistic Disorder ,Child ,Molecular Biology ,Brain Mapping ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,Research ,220 Statistical Imaging Neuroscience ,Brain ,Reproducibility of Results ,Electroencephalography ,10058 Department of Child and Adolescent Psychiatry ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,Cross-Sectional Studies ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Developmental Biology - Abstract
Background Understanding the development of the neuronal circuitry underlying autism spectrum disorder (ASD) is critical to shed light into its etiology and for the development of treatment options. Resting state EEG provides a window into spontaneous local and long-range neuronal synchronization and has been investigated in many ASD studies, but results are inconsistent. Unbiased investigation in large and comprehensive samples focusing on replicability is needed. Methods We quantified resting state EEG alpha peak metrics, power spectrum (PS, 2–32 Hz) and functional connectivity (FC) in 411 children, adolescents and adults (n = 212 ASD, n = 199 neurotypicals [NT], all with IQ > 75). We performed analyses in source-space using individual head models derived from the participants’ MRIs. We tested for differences in mean and variance between the ASD and NT groups for both PS and FC using linear mixed effects models accounting for age, sex, IQ and site effects. Then, we used machine learning to assess whether a multivariate combination of EEG features could better separate ASD and NT participants. All analyses were embedded within a train-validation approach (70%–30% split). Results In the training dataset, we found an interaction between age and group for the reactivity to eye opening (p = .042 uncorrected), and a significant but weak multivariate ASD vs. NT classification performance for PS and FC (sensitivity 0.52–0.62, specificity 0.59–0.73). None of these findings replicated significantly in the validation dataset, although the effect size in the validation dataset overlapped with the prediction interval from the training dataset. Limitations The statistical power to detect weak effects—of the magnitude of those found in the training dataset—in the validation dataset is small, and we cannot fully conclude on the reproducibility of the training dataset’s effects. Conclusions This suggests that PS and FC values in ASD and NT have a strong overlap, and that differences between both groups (in both mean and variance) have, at best, a small effect size. Larger studies would be needed to investigate and replicate such potential effects., Molecular Autism, 13
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- 2022
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19. Association between white matter fiber integrity and subclinical psychotic symptoms in schizophrenia patients and unaffected relatives
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Knöchel, Christian, O'Dwyer, Laurence, Alves, Gilberto, Reinke, Britta, Magerkurth, Jörg, Rotarska-Jagiela, Anna, Prvulovic, David, Hampel, Harald, Linden, David E.J., and Oertel-Knöchel, Viola
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- 2012
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20. Association of microstructural white matter abnormalities with cognitive dysfunction in geriatric patients with major depression
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Alves, Gilberto Sousa, Karakaya, Tarik, Fußer, Fabian, Kordulla, Martha, O'Dwyer, Laurence, Christl, Julia, Magerkurth, Jörg, Oertel-Knöchel, Viola, Knöchel, Christian, Prvulovic, David, Jurcoane, Alina, Laks, Jerson, Engelhardt, Eliasz, Hampel, Harald, and Pantel, Johannes
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- 2012
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21. Patterns of connectome variability in autism across five functional activation tasks:Findings from the LEAP project
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Looden, Tristan, Floris, Dorothea L., Llera, Alberto, Chauvin, Roselyne J., Charman, Tony, Banaschewski, Tobias, Murphy, Declan G. M., Marquand, Andre. F., Buitelaar, Jan K., Beckmann, Christian F., Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Baron-cohen, Simon, Baumeister, Sarah, Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, De Bruijn, Yvette, Chakrabarti, Bhismadev, Cornelissen, Ineke, Crawley, Daisy, Acqua, Flavio Dell’, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary, Johnson, Mark H., Jones, Emily J. H., Kundu, Prantik, Lai, Meng-chuan, D’ardhuy, Xavier Liogier, Lombardo, Michael V., Loth, Eva, Lythgoe, David J., Mandl, René, Marquand, Andre, Mason, Luke, Mennes, Maarten, Meyer-lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, Oakley, Bethany, O’dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Rausch, Annika, Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Spooren, Will, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C. R., Wooldridge, Caroline, Ilioska, Iva, Mei, Ting, and Zwiers, Marcel P.
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Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,fMRI ,functional connectivity ,Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] ,220 Statistical Imaging Neuroscience ,autism ,Psychiatry and Mental health ,All institutes and research themes of the Radboud University Medical Center ,Developmental Neuroscience ,normative modeling ,heterogeneity ,Molecular Biology ,Developmental Biology ,canonical correlation analysis - Abstract
Background Autism spectrum disorder (autism) is a complex neurodevelopmental condition with pronounced behavioral, cognitive, and neural heterogeneities across individuals. Here, our goal was to characterize heterogeneity in autism by identifying patterns of neural diversity as reflected in BOLD fMRI in the way individuals with autism engage with a varied array of cognitive tasks. Methods All analyses were based on the EU-AIMS/AIMS-2-TRIALS multisite Longitudinal European Autism Project (LEAP) with participants with autism (n = 282) and typically developing (TD) controls (n = 221) between 6 and 30 years of age. We employed a novel task potency approach which combines the unique aspects of both resting state fMRI and task-fMRI to quantify task-induced variations in the functional connectome. Normative modelling was used to map atypicality of features on an individual basis with respect to their distribution in neurotypical control participants. We applied robust out-of-sample canonical correlation analysis (CCA) to relate connectome data to behavioral data. Results Deviation from the normative ranges of global functional connectivity was greater for individuals with autism compared to TD in each fMRI task paradigm (all tasks p p Conclusions Individuals with autism engage with tasks in a globally atypical way, but the particular spatial pattern of this atypicality is nevertheless similar across tasks. Atypicalities in the tasks originate mostly from prefrontal cortex and default mode network regions, but also speech and auditory networks. We show how sophisticated modeling methods such as task potency and normative modeling can be used toward unravelling complex heterogeneous conditions like autism.
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- 2022
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22. Preference for biological motion is reduced in ASD: implications for clinical trials and the search for biomarkers
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Mason, L., Shic, F., Falck-Ytter, T., Chakrabarti, B., Charman, T., Loth, E., Tillmann, J., Banaschewski, T., Baron-Cohen, S., Bölte, S., Buitelaar, J., Durston, S., Oranje, B., Persico, A. M., Beckmann, C., Bougeron, T., Dell’Acqua, F., Ecker, C., Moessnang, C., Murphy, D., Johnson, M. H., Jones, E. J. H., Ahmad, Jumana, Ambrosino, Sara, Baumeister, Sarah, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Chatham, Chris, Cornelissen, Ineke, Crawley, Daisy, Dumas, Guillaume, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hipp, Joerg, Holt, Rosemary, Lai, Meng-Chuan, D’ardhuy, Xavier Liogier, Lombardo, Michael V., Lythgoe, David J., Mandl, René, Marquand, Andre, Mennes, Maarten, Meyer-Lindenberg, Andreas, Bast, Nico, Oakley, Bethany, O’Dwyer, Laurence, Oldehinkel, Marianne, Pandina, Gahan, Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Spooren, Will, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C. R., Wooldridge, Caroline, Zwiers, Marcel P., Mason, L [0000-0001-9978-7349], Baron-Cohen, Simon [0000-0001-9217-2544], Johnson, Mark [0000-0003-4229-2585], and Apollo - University of Cambridge Repository
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Eye tracking ,Psykologi ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,Adolescent ,Autism Spectrum Disorder ,Research ,Autism ,Biomarker ,Biological motion ,Development ,Severity of Illness Index ,Psychiatry and Mental health ,Young Adult ,Developmental Neuroscience ,Case-Control Studies ,Psychology ,Humans ,Neurology. Diseases of the nervous system ,Autistic Disorder ,Child ,RC346-429 ,Molecular Biology ,Biomarkers ,Developmental Biology - Abstract
Background The neurocognitive mechanisms underlying autism spectrum disorder (ASD) remain unclear. Progress has been largely hampered by small sample sizes, variable age ranges and resulting inconsistent findings. There is a pressing need for large definitive studies to delineate the nature and extent of key case/control differences to direct research towards fruitful areas for future investigation. Here we focus on perception of biological motion, a promising index of social brain function which may be altered in ASD. In a large sample ranging from childhood to adulthood, we assess whether biological motion preference differs in ASD compared to neurotypical participants (NT), how differences are modulated by age and sex and whether they are associated with dimensional variation in concurrent or later symptomatology. Methods Eye-tracking data were collected from 486 6-to-30-year-old autistic (N = 282) and non-autistic control (N = 204) participants whilst they viewed 28 trials pairing biological (BM) and control (non-biological, CTRL) motion. Preference for the biological motion stimulus was calculated as (1) proportion looking time difference (BM-CTRL) and (2) peak look duration difference (BM-CTRL). Results The ASD group showed a present but weaker preference for biological motion than the NT group. The nature of the control stimulus modulated preference for biological motion in both groups. Biological motion preference did not vary with age, gender, or concurrent or prospective social communicative skill within the ASD group, although a lack of clear preference for either stimulus was associated with higher social-communicative symptoms at baseline. Limitations The paired visual preference we used may underestimate preference for a stimulus in younger and lower IQ individuals. Our ASD group had a lower average IQ by approximately seven points. 18% of our sample was not analysed for various technical and behavioural reasons. Conclusions Biological motion preference elicits small-to-medium-sized case–control effects, but individual differences do not strongly relate to core social autism associated symptomatology. We interpret this as an autistic difference (as opposed to a deficit) likely manifest in social brain regions. The extent to which this is an innate difference present from birth and central to the autistic phenotype, or the consequence of a life lived with ASD, is unclear.
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- 2021
23. Developmentally Stable Whole-Brain Volume Reductions and Developmentally Sensitive Caudate and Putamen Volume Alterations in Those With Attention-Deficit/Hyperactivity Disorder and Their Unaffected Siblings
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Greven, Corina U., Bralten, Janita, Mennes, Maarten, O’Dwyer, Laurence, van Hulzen, Kimm J. E., Rommelse, Nanda, Schweren, Lizanne J. S., Hoekstra, Pieter J., Hartman, Catharina A., Heslenfeld, Dirk, Oosterlaan, Jaap, Faraone, Stephen V., Franke, Barbara, Zwiers, Marcel P., Arias-Vasquez, Alejandro, and Buitelaar, Jan K.
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- 2015
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24. Temporal Profiles of Social Attention Are Different Across Development in Autistic and Neurotypical People
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Del Bianco, Teresa, primary, Mason, Luke, additional, Charman, Tony, additional, Tillman, Julian, additional, Loth, Eva, additional, Hayward, Hannah, additional, Shic, Frederick, additional, Buitelaar, Jan, additional, Johnson, Mark H., additional, Jones, Emily J.H., additional, Ahmad, Jumana, additional, Ambrosino, Sara, additional, Banaschewski, Tobias, additional, Baron-Cohen, Simon, additional, Baumeister, Sarah, additional, Beckmann, Christian F., additional, Bölte, Sven, additional, Bourgeron, Thomas, additional, Bours, Carsten, additional, Brammer, Michael, additional, Brandeis, Daniel, additional, Brogna, Claudia, additional, de Bruijn, Yvette, additional, Cornelissen, Ineke, additional, Crawley, Daisy, additional, Dell’Acqua, Flavio, additional, Dumas, Guillaume, additional, Durston, Sarah, additional, Ecker, Christine, additional, Faulkner, Jessica, additional, Frouin, Vincent, additional, Garcés, Pilar, additional, Goyard, David, additional, Ham, Lindsay, additional, Hipp, Joerg, additional, Holt, Rosemary, additional, Lai, Meng-Chuan, additional, D’Ardhuy, Xavier Liogier, additional, Lombardo, Michael V., additional, Lythgoe, David J., additional, Mandl, René, additional, Marquand, Andre, additional, Mennes, Maarten, additional, Meyer-Lindenberg, Andreas, additional, Moessnang, Carolin, additional, Mueller, Nico, additional, Murphy, Declan G.M., additional, Oakley, Bethany, additional, O’Dwyer, Laurence, additional, Oldehinkel, Marianne, additional, Oranje, Bob, additional, Pandina, Gahan, additional, Persico, Antonio M., additional, Ruggeri, Barbara, additional, Ruigrok, Amber, additional, Sabet, Jessica, additional, Sacco, Roberto, additional, San José Cáceres, Antonia, additional, Simonoff, Emily, additional, Spooren, Will, additional, Toro, Roberto, additional, Tost, Heike, additional, Waldman, Jack, additional, Williams, Steve C.R., additional, Wooldridge, Caroline, additional, and Zwiers, Marcel P., additional
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- 2021
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25. Atypical Brain Asymmetry in Autism—A Candidate for Clinically Meaningful Stratification
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Floris, Dorothea L., primary, Wolfers, Thomas, additional, Zabihi, Mariam, additional, Holz, Nathalie E., additional, Zwiers, Marcel P., additional, Charman, Tony, additional, Tillmann, Julian, additional, Ecker, Christine, additional, Dell’Acqua, Flavio, additional, Banaschewski, Tobias, additional, Moessnang, Carolin, additional, Baron-Cohen, Simon, additional, Holt, Rosemary, additional, Durston, Sarah, additional, Loth, Eva, additional, Murphy, Declan G.M., additional, Marquand, Andre, additional, Buitelaar, Jan K., additional, Beckmann, Christian F., additional, Ahmad, Jumana, additional, Ambrosino, Sara, additional, Auyeung, Bonnie, additional, Baumeister, Sarah, additional, Bölte, Sven, additional, Bourgeron, Thomas, additional, Bours, Carsten, additional, Brammer, Michael, additional, Brandeis, Daniel, additional, Brogna, Claudia, additional, de Bruijn, Yvette, additional, Chakrabarti, Bhismadev, additional, Cornelissen, Ineke, additional, Crawley, Daisy, additional, Dumas, Guillaume, additional, Faulkner, Jessica, additional, Frouin, Vincent, additional, Garcés, Pilar, additional, Goyard, David, additional, Ham, Lindsay, additional, Hayward, Hannah, additional, Hipp, Joerg, additional, Johnson, Mark H., additional, Jones, Emily J.H., additional, Kundu, Prantik, additional, Lai, Meng-Chuan, additional, Liogier d’Ardhuy, Xavier, additional, Lombardo, Michael V., additional, Lythgoe, David J., additional, Mandl, René, additional, Mason, Luke, additional, Mennes, Maarten, additional, Meyer-Lindenberg, Andreas, additional, Mueller, Nico, additional, Oakley, Bethany, additional, O’Dwyer, Laurence, additional, Oldehinkel, Marianne, additional, Oranje, Bob, additional, Pandina, Gahan, additional, Persico, Antonio M., additional, Ruggeri, Barbara, additional, Ruigrok, Amber, additional, Sabet, Jessica, additional, Sacco, Roberto, additional, San José Cáceres, Antonia, additional, Simonoff, Emily, additional, Spooren, Will, additional, Toro, Roberto, additional, Tost, Heike, additional, Waldman, Jack, additional, Williams, Steve C.R., additional, and Wooldridge, Caroline, additional
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- 2021
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26. Therapeutic genome editing: regulatory horizons
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Hines, Philip A., primary, Agricola, Eleonora, additional, Llinares Garcia, Jordi, additional, O’Dwyer, Laurence, additional, and Herold, Ralf, additional
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- 2021
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27. Cognitive and behavioural effects of physical exercise in psychiatric patients
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Knöchel, Christian, Oertel-Knöchel, Viola, O’Dwyer, Laurence, Prvulovic, David, Alves, Gilberto, Kollmann, Bianca, and Hampel, Harald
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- 2012
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28. Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project
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Tillmann, Julian, San José Cáceres, Antonia, Chatham, Chris H., Crawley, Daisy, Holt, Rosemary, Oakley, Bethany, Banaschewski, Tobias, Baron-Cohen, Simon, Bölte, Sven, Buitelaar, Jan K., Durston, Sarah, Ham, Lindsay, Loth, Eva, Simonoff, Emily, Spooren, Will, Murphy, Declan G., Charman, Tony, Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Baumeister, Sarah, Beckmann, Christian, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Chakrabarti, Bhismadev, Cornelissen, Ineke, Dell’ Acqua, Flavio, Dumas, Guillaume, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Goyard, David, Hayward, Hannah, Hipp, Joerg, Johnson, Mark H., Jones, Emily J. H., Kundu, Prantik, Lai, Meng-Chuan, D'Ardhuy, Xavier Liogier, Lombardo, Michael, Lythgoe, David J., Mandl, René, Mason, Luke, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C. R., Wooldridge, Caroline, Zwiers, Marcel P., Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, University of Vienna [Vienna], F. Hoffmann-La Roche [Basel], University of Cambridge [UK] (CAM), Department of Child and Adolescent Psychiatry and Psychotherapy [Mannheim], Universität Heidelberg [Heidelberg] = Heidelberg University, Central Institute of Mental Health [Mannheim], University Hospital Mannheim | Universitätsmedizin Mannheim, Karolinska Institutet [Stockholm], Donders Institute for Brain, Cognition and Behaviour, Radboud University [Nijmegen], Stockholm County Council, University Medical Center [Utrecht], Karakter Child and Adolescent Psychiatry University Centre [Nijmegen], South London and Maudsley NHS Foundation Trust, This work was supported by EU‐AIMS (European Autism Interventions), which receives support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115300, the resources of which are composed of financial contributions from the European Union's Seventh Framework Programme (grant FP7/2007‐2013), from the European Federation of Pharmaceutical Industries and Associations companies' in‐kind contributions, and from Autism Speaks, The EU‐AIMS LEAP group : Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Sarah Baumeister, Christian Beckmann, Thomas Bourgeron, Carsten Bours, Michael Brammer, Daniel Brandeis, Claudia Brogna, Yvette de Bruijn, Bhismadev Chakrabarti, Ineke Cornelissen, Flavio Dell’ Acqua, Guillaume Dumas, Christine Ecker, Jessica Faulkner, Vincent Frouin, Pilar Garcés, David Goyard, Hannah Hayward, Joerg Hipp, Mark H. Johnson, Emily J.H. Jones, Prantik Kundu, Meng‐Chuan Lai, Xavier Liogier D'ardhuy, Michael Lombardo, David J. Lythgoe, René Mandl, Luke Mason, Andreas Meyer‐Lindenberg, Carolin Moessnang, Nico Mueller, Laurence O'Dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M. Persico, Barbara Ruggeri, Amber Ruigrok, Jessica Sabet, Roberto Sacco, Roberto Toro, Heike Tost, Jack Waldman, Steve C.R. Williams, Caroline Wooldridge, and Marcel P. Zwiers., We thank all participants and their families for their efforts to participate in the study., European Project: 115300,EC:FP7:SP1-JTI,IMI-JU-03-2010,EU-AIMS(2012), Universität Heidelberg [Heidelberg], Medical Faculty [Mannheim], Radboud university [Nijmegen], Tillmann, Julian [0000-0001-9574-9855], Bölte, Sven [0000-0002-4579-4970], Charman, Tony [0000-0003-1993-6549], and Apollo - University of Cambridge Repository
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Male ,Intelligence ,Psychological intervention ,Severity of Illness Index ,Cohort Studies ,0302 clinical medicine ,Borderline intellectual functioning ,Activities of Daily Living ,Psychology ,Longitudinal Studies ,Child ,Genetics (clinical) ,Research Articles ,Adaptive behavior ,General Neuroscience ,05 social sciences ,Age Factors ,Cognition ,Europe ,symptom severity ,Phenotype ,Autism spectrum disorder ,Cohort ,Anxiety ,Female ,medicine.symptom ,adaptive functioning ,autism spectrum disorder ,intellectual functioning ,psychiatric symptoms ,Neuroscience (all) ,Neurology (clinical) ,050104 developmental & child psychology ,Clinical psychology ,Research Article ,Adult ,Adolescent ,03 medical and health sciences ,Young Adult ,Sex Factors ,mental disorders ,medicine ,Humans ,0501 psychology and cognitive sciences ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,medicine.disease ,[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Autism ,030217 neurology & neurosurgery - Abstract
Contains fulltext : 204820.pdf (Publisher’s version ) (Closed access) Individuals with autism spectrum disorder (ASD) exhibit significant impairments in adaptive functioning that impact on their ability to meet the demands of everyday life. A recurrent finding is that there is a pronounced discrepancy between level of cognitive ability and adaptive functioning, and this is particularly prominent among higher-ability individuals. However, the key clinical and demographic associations of these discrepancies remain unclear. This study included a sample of 417 children, adolescents, and adults with ASD as part of the EU-AIMS LEAP cohort. We examined how age, sex, IQ, levels of ASD symptom and autistic trait severity and psychiatric symptomatology are associated with adaptive functioning as measured by the Vineland Adaptive Behavior Scales-Second Edition and IQ-adaptive functioning discrepancies. Older age, lower IQ and higher social-communication symptoms were associated with lower adaptive functioning. Results also demonstrate that older age, higher IQ and higher social-communication symptoms are associated with greater IQ-adaptive functioning discrepancy scores. By contrast, sensory ASD symptoms, repetitive and restricted behaviors, as well as symptoms of attention deficit/hyperactivity disorder (ADHD), anxiety and depression, were not associated with adaptive functioning or IQ-adaptive functioning discrepancy scores. These findings suggest that it is the core social communication problems that define ASD that contribute to adaptive function impairments that people with ASD experience. They show for the first time that sensory symptoms, repetitive behavior and associated psychiatric symptoms do not independently contribute to adaptive function impairments. Individuals with ASD require supportive interventions across the lifespan that take account of social-communicative ASD symptom severity. Autism Res 2019, 12: 645-657. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: This study investigated key clinical and demographic associations of adaptive functioning impairments in individuals with autism. We found that older age, lower IQ and more severe social-communicative symptoms, but not sensory or repetitive symptoms or co-occurring psychiatric symptoms, are associated with lower adaptive functioning and greater ability-adaptive function discrepancies. This suggests that interventions targeting adaptive skills acquisition should be flexible in their timing and intensity across developmental periods, levels of cognitive ability and take account of social-communicative ASD symptom severity.
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- 2019
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29. EU-AIMS Longitudinal European Autism Project (LEAP):The autism twin cohort
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Isaksson, Johan, Tammimies, Kristiina, Neufeld, Janina, Cauvet, Élodie, Lundin, Karl, Buitelaar, Jan K., Loth, Eva, Murphy, Declan G. M., Spooren, Will, Bölte, Sven, Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Chakrabarti, Bhismadev, Charman, Tony, Crawley, Daisy, Cornelissen, Ineke, Dell’ Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary J., Johnson, Mark H., Jones, Emily J. H., Kundu, Prantik, Lai, Meng-Chuan, D’ardhuy, Xavier Liogier, Lombardo, Michael, Lythgoe, David J., Mandl, René, Mason, Luke, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O’Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C. R., Wooldridge, Caroline, Zwiers, Marcel P., the EU-AIMS LEAP group, Bölte, Sven [0000-0002-4579-4970], Apollo - University of Cambridge Repository, and Lombardo, Michael [0000-0001-6780-8619]
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Male ,Psychological intervention ,Twins ,lcsh:RC346-429 ,Cohort Studies ,0302 clinical medicine ,Cognition ,Intellectual disability ,Twins, Dizygotic ,Longitudinal Studies ,Autism spectrum disorder ,Child ,Letter to the Editor ,Psychiatry ,05 social sciences ,Neuropsychology ,Brain ,Europe ,Psychiatry and Mental health ,Phenotype ,Cohort ,Female ,Psychology ,050104 developmental & child psychology ,Clinical psychology ,Adolescent ,BF ,Intervention ,Family income ,Psykiatri ,03 medical and health sciences ,Developmental Neuroscience ,mental disorders ,medicine ,Genetics ,Humans ,ADHD ,0501 psychology and cognitive sciences ,Autistic Disorder ,Molecular Biology ,lcsh:Neurology. Diseases of the nervous system ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,Twins, Monozygotic ,medicine.disease ,FOS: Biological sciences ,Autism ,Biomarkers ,030217 neurology & neurosurgery ,Developmental Biology - Abstract
ᅟ EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has recruited and comprehensively phenotyped a rare sample of 76 monozygotic and dizygotic twins, discordant, or concordant for ASD plus 30 typically developing twins. The aim of this letter is to complete previous descriptions of the LEAP case-control sample, clinically characterize, and investigate the suitability of the sample for ASD twin-control analyses purposes and share some ‘lessons learnt.’ Among the twins, a diagnosis of ASD is associated with increased symptom levels of ADHD, higher rates of intellectual disability, and lower family income. For the future, we conclude that the LEAP twin cohort offers multiple options for analyses of genetic and shared and non-shared environmental factors to generate new hypotheses for the larger cohort of LEAP singletons, but particularly cross-validate and refine evidence from it. Electronic supplementary material The online version of this article (10.1186/s13229-018-0212-x) contains supplementary material, which is available to authorized users.
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- 2018
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30. Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project
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Oldehinkel, Marianne, primary, Mennes, Maarten, additional, Marquand, Andre, additional, Charman, Tony, additional, Tillmann, Julian, additional, Ecker, Christine, additional, Dell’Acqua, Flavio, additional, Brandeis, Daniel, additional, Banaschewski, Tobias, additional, Baumeister, Sarah, additional, Moessnang, Carolin, additional, Baron-Cohen, Simon, additional, Holt, Rosemary, additional, Bölte, Sven, additional, Durston, Sarah, additional, Kundu, Prantik, additional, Lombardo, Michael V., additional, Spooren, Will, additional, Loth, Eva, additional, Murphy, Declan G.M., additional, Beckmann, Christian F., additional, Buitelaar, Jan K., additional, Ahmad, Jumana, additional, Ambrosino, Sara, additional, Auyeung, Bonnie, additional, Bourgeron, Thomas, additional, Bours, Carsten, additional, Brammer, Michael, additional, Brogna, Claudia, additional, de Bruijn, Yvette, additional, Chakrabarti, Bhismadev, additional, Cornelissen, Ineke, additional, Crawley, Daisy, additional, Dumas, Guillaume, additional, Faulkner, Jessica, additional, Frouin, Vincent, additional, Garcés, Pilar, additional, Goyard, David, additional, Ham, Lindsay, additional, Hayward, Hannah, additional, Hipp, Joerg, additional, Johnson, Mark H., additional, Jones, Emily J.H., additional, Lai, Meng-Chuan, additional, Liogier D’ardhuy, Xavier, additional, Lythgoe, David J., additional, Mandl, René, additional, Mason, Luke, additional, Meyer-Lindenberg, Andreas, additional, Mueller, Nico, additional, Oakley, Bethany, additional, O’Dwyer, Laurence, additional, Oldehinkel, Marianne, additional, Oranje, Bob, additional, Pandina, Gahan, additional, Persico, Antonio M., additional, Ruggeri, Barbara, additional, Ruigrok, Amber, additional, Sabet, Jessica, additional, Sacco, Roberto, additional, Cáceres, Antonia San José, additional, Simonoff, Emily, additional, Toro, Roberto, additional, Tost, Heike, additional, Waldman, Jack, additional, Williams, Steve C.R., additional, Wooldridge, Caroline, additional, and Zwiers, Marcel P., additional
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- 2019
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31. Avenida Libertador
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O’Dwyer, Laurence, primary
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- 2019
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32. EU-AIMS Longitudinal European Autism Project (LEAP) : The autism twin cohort
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Isaksson, Johan, Tammimies, Kristiina, Neufeld, Janina, Cauvet, Élodie, Lundin, Karl, Buitelaar, Jan K., Loth, Eva, Murphy, Declan G.M., Spooren, Will, Bölte, Sven, Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, De Bruijn, Yvette, Chakrabarti, Bhismadev, Charman, Tony, Crawley, Daisy, Cornelissen, Ineke, Dell'Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary J., Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng Chuan, D'Ardhuy, Xavier Liogier, Lombardo, Michael, Lythgoe, David J., Mandl, René, Mason, Luke, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, Zwiers, Marcel P., Isaksson, Johan, Tammimies, Kristiina, Neufeld, Janina, Cauvet, Élodie, Lundin, Karl, Buitelaar, Jan K., Loth, Eva, Murphy, Declan G.M., Spooren, Will, Bölte, Sven, Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, De Bruijn, Yvette, Chakrabarti, Bhismadev, Charman, Tony, Crawley, Daisy, Cornelissen, Ineke, Dell'Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary J., Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng Chuan, D'Ardhuy, Xavier Liogier, Lombardo, Michael, Lythgoe, David J., Mandl, René, Mason, Luke, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, and Zwiers, Marcel P.
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- 2018
33. EU-AIMS Longitudinal European Autism Project (LEAP): The autism twin cohort
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Ontwikkelingsstoornissen Ond., Brain, Onderzoeksgroep 8, Onderzoek Bob Oranje, Isaksson, Johan, Tammimies, Kristiina, Neufeld, Janina, Cauvet, Élodie, Lundin, Karl, Buitelaar, Jan K., Loth, Eva, Murphy, Declan G.M., Spooren, Will, Bölte, Sven, Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, De Bruijn, Yvette, Chakrabarti, Bhismadev, Charman, Tony, Crawley, Daisy, Cornelissen, Ineke, Dell'Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary J., Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng Chuan, D'Ardhuy, Xavier Liogier, Lombardo, Michael, Lythgoe, David J., Mandl, René, Mason, Luke, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, Zwiers, Marcel P., Ontwikkelingsstoornissen Ond., Brain, Onderzoeksgroep 8, Onderzoek Bob Oranje, Isaksson, Johan, Tammimies, Kristiina, Neufeld, Janina, Cauvet, Élodie, Lundin, Karl, Buitelaar, Jan K., Loth, Eva, Murphy, Declan G.M., Spooren, Will, Bölte, Sven, Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, De Bruijn, Yvette, Chakrabarti, Bhismadev, Charman, Tony, Crawley, Daisy, Cornelissen, Ineke, Dell'Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary J., Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng Chuan, D'Ardhuy, Xavier Liogier, Lombardo, Michael, Lythgoe, David J., Mandl, René, Mason, Luke, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, and Zwiers, Marcel P.
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- 2018
34. The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation
- Author
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Charman, T., Loth, Eva, Tillmann, Julian, Crawley, Daisy, Wooldridge, C., Goyard, David, Ahmad, Jumana, Auyeung, Bonnie, Ambrosino, Sara, Banaschewski, Tobias, Baron-Cohen,Simon, Baumeister, Sarah, Beckmann, Christian, Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, De Bruijn, Y., Chakrabarti,B., Cornelissen, Ineke, Acqua, Flavio Dell, Dumas, G., Durston, Sarah, Ecker,C., Faulkner, J., Frouin, Vincent, Garces, Pilar, Ham, Lindsay M., Hayward, Hannah, Hipp, Joerg, Holt, R. J., Isaksson, Johan, Johnson, Mark H., Jones, Emily J. H., Kundu, Prantik, Lai,Meng-Chuan, D'Ardhuy, X. L., Lombardo, Michael V., Lythgoe, David J., Mandl, Rene, Mason, Luke, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan J., Persico, Antonio M., Ruggeri, B., Ruigrok,Amber N. V., Sabet, Jessica, Sacco, Roberto, Caceres, Antonia San Jose, Simonoff, Emily, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams,Steven C. R., Zwiers, Marcel P., Spooren, Will, Murphy,Declan G. M., Buitelaar, Jan K., Lombardo,Michael V., Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, University of Edinburgh, Autism Research Centre and Section of Developmental Psychiatry, University of Cambridge [UK] ( CAM ), University Medical Center [Utrecht], Universität Heidelberg [Heidelberg], Medizinische Fakultät Mannheim, Radboud University Medical Center [Nijmegen], Karolinska Institutet [Stockholm], Génétique humaine et Fonctions cognitives - Human Genetics and Cognitive Functions, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM ), University of Reading ( UOR ), Goethe-University Frankfurt am Main, Roche Pharma Research and Early Development [Basel] ( pRED ), F. Hoffmann-La Roche [Basel], Uppsala University, Centre for Brain and Cognitive Development [Birkbeck College], Birkbeck College [University of London], Icahn School of Medicine at Mount Sinai [New York], University of Toronto, University of Cyprus [Nicosia], Janssen Research & Development, University of Messina, This work was supported by EU-AIMS (European Autism Interventions), which receives support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115300, the resources of which are composed of financial contributions from the European Union’s Seventh Framework Programme (grant FP7/2007-2013), from the European Federation of Pharmaceutical Industries and Associations companies’ inkind contributions, and from Autism Speaks., European Project : 115300,EC:FP7:SP1-JTI,IMI-JU-03-2010,EU-AIMS ( 2012 ), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University of Cambridge [UK] (CAM), Department of Child and Adolescent Psychiatry and Psychotherapy [Mannheim], Universität Heidelberg [Heidelberg] = Heidelberg University, Stockholm County Council, Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), University of Reading (UOR), Universitätsklinikum Frankfurt, Roche Pharma Research and Early Development [Basel] (pRED), University of London [London], Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Cyprus [Nicosia] (UCY), Donders Institute for Brain, Cognition and Behaviour, Radboud University [Nijmegen], This work was supported by EU-AIMS (European Autism Interventions), which receives support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115300, the resources of which are composed of financial contributions from the European Union’s Seventh Framework Programme (grant FP7/2007-2013), from the European Federation of Pharmaceutical Industries and Associations companies’ in-kind contributions, and from Autism Speaks., European Project: 115300,EC:FP7:SP1-JTI,IMI-JU-03-2010,EU-AIMS(2012), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Radboud university [Nijmegen], Lombardo, Michael V. [0000-0001-6780-8619], Charman, Tony [0000-0003-1993-6549], Loth, Eva [0000-0001-9458-9167], Tillmann, Julian [0000-0001-9574-9855], Crawley, Daisy [0000-0001-9901-1110], Ahmad, Jumana [0000-0001-5271-0731], Banaschewski, Tobias [0000-0003-4595-1144], Baron-Cohen, Simon [0000-0001-9217-2544], Brogna, Claudia [0000-0002-9526-6367], Dumas, Guillaume [0000-0002-2253-1844], Hayward, Hannah [0000-0001-5552-2146], Hipp, Joerg [0000-0002-7875-2988], Isaksson, Johan [0000-0003-1033-2618], Johnson, Mark [0000-0003-4229-2585], Jones, Emily JH [0000-0001-5747-9540], Lai, Meng-Chuan [0000-0002-9593-5508], Lythgoe, David J [0000-0002-5078-9025], Moessnang, Carolin [0000-0003-4357-2706], Ruggeri, Barbara [0000-0002-6231-8829], Ruigrok, Amber [0000-0001-7711-8056], Simonoff, Emily [0000-0002-5450-0823], Toro, Roberto [0000-0002-6671-858X], Williams, Steve CR [0000-0003-4299-1941], Murphy, Declan GM [0000-0002-6664-7451], and Apollo - University of Cambridge Repository
- Subjects
Parents ,Male ,[SDV]Life Sciences [q-bio] ,Autism ,[ SDV.MHEP.PSM ] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] ,Individuality ,Behaviours ,Severity of Illness Index ,lcsh:RC346-429 ,psyc ,0302 clinical medicine ,Age ,autism ,autism spectrum disorder ,behaviours ,heterogeneity ,IQ ,phenotype ,sex ,molecular biology ,developmental neuroscience ,developmental biology ,psychiatry and mental health ,Surveys and Questionnaires ,Longitudinal Studies ,Autism spectrum disorder ,Child ,Psychiatry ,Age, autism, autism spectrum disorder, behaviours, heterogeneity, IQ, phenotype, sex, molecular biology, developmental neuroscience, developmental biology, psychiatry and mental health ,05 social sciences ,Neuropsychology ,Age Factors ,220 Statistical Imaging Neuroscience ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,Cognition ,Psychiatry and Mental health ,Phenotype ,Cohort ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Female ,Sex ,Psychology ,050104 developmental & child psychology ,Adult ,medicine.medical_specialty ,Adolescent ,BF ,behavioral disciplines and activities ,150 000 MR Techniques in Brain Function ,Psykiatri ,03 medical and health sciences ,Genetic Heterogeneity ,[ SHS.PSY ] Humanities and Social Sciences/Psychology ,Sex Factors ,Developmental Neuroscience ,Severity of illness ,mental disorders ,medicine ,Journal Article ,Humans ,0501 psychology and cognitive sciences ,Molecular Biology ,lcsh:Neurology. Diseases of the nervous system ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,Research ,medicine.disease ,R1 ,Clinical trial ,Impulsive Behavior ,Observational study ,Self Report ,Heterogeneity ,030217 neurology & neurosurgery ,Biomarkers ,Developmental Biology - Abstract
Background The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ differences in ASD core symptoms and common co-occurring psychiatric symptoms. A companion paper describes the overall design and experimental protocol and outlines the strategy to identify stratification biomarkers. Methods From six research centres in four European countries, we recruited 437 children and adults with ASD and 300 controls between the ages of 6 and 30 years with IQs varying between 50 and 148. We conducted in-depth clinical characterisation including a wide range of observational, interview and questionnaire measures of the ASD phenotype, as well as co-occurring psychiatric symptoms. Results The cohort showed heterogeneity in ASD symptom presentation, with only minimal to moderate site differences on core clinical and cognitive measures. On both parent-report interview and questionnaire measures, ASD symptom severity was lower in adults compared to children and adolescents. The precise pattern of differences varied across measures, but there was some evidence of both lower social symptoms and lower repetitive behaviour severity in adults. Males had higher ASD symptom scores than females on clinician-rated and parent interview diagnostic measures but not on parent-reported dimensional measures of ASD symptoms. In contrast, self-reported ASD symptom severity was higher in adults compared to adolescents, and in adult females compared to males. Higher scores on ASD symptom measures were moderately associated with lower IQ. Both inattentive and hyperactive/impulsive ADHD symptoms were lower in adults than in children and adolescents, and males with ASD had higher levels of inattentive and hyperactive/impulsive ADHD symptoms than females. Conclusions The established phenotypic heterogeneity in ASD is well captured in the LEAP cohort. Variation both in core ASD symptom severity and in commonly co-occurring psychiatric symptoms were systematically associated with sex, age and IQ. The pattern of ASD symptom differences with age and sex also varied by whether these were clinician ratings or parent- or self-reported which has important implications for establishing stratification biomarkers and for their potential use as outcome measures in clinical trials. Electronic supplementary material The online version of this article (doi:10.1186/s13229-017-0145-9) contains supplementary material, which is available to authorized users.
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- 2017
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35. The EU-AIMS Longitudinal European Autism Project (LEAP) : design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders.
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Loth, Eva, Charman, Tony, Mason, Luke, Tillmann, Julian, Jones, Emily J H, Wooldridge, Caroline, Ahmad, Jumana, Auyeung, Bonnie, Brogna, Claudia, Ambrosino, Sara, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian, Brammer, Michael, Brandeis, Daniel, Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, de Bruijn, Yvette, Chakrabarti, Bhismadev, Crawley, Daisy, Cornelissen, Ineke, Acqua, Flavio Dell', Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garces, Pilar, Goyard, David, Hayward, Hannah, Ham, Lindsay M, Hipp, Joerg, Holt, Rosemary J, Johnson, Mark H, Isaksson, Johan, Kundu, Prantik, Lai, Meng-Chuan, D'ardhuy, Xavier Liogier, Lombardo, Michael V, Lythgoe, David J, Mandl, René, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M, Ruigrok, Amber N V, Ruggeri, Barbara, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C R, Zwiers, Marcel P, Spooren, Will, Murphy, Declan G M, Buitelaar, Jan K, Loth, Eva, Charman, Tony, Mason, Luke, Tillmann, Julian, Jones, Emily J H, Wooldridge, Caroline, Ahmad, Jumana, Auyeung, Bonnie, Brogna, Claudia, Ambrosino, Sara, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian, Brammer, Michael, Brandeis, Daniel, Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, de Bruijn, Yvette, Chakrabarti, Bhismadev, Crawley, Daisy, Cornelissen, Ineke, Acqua, Flavio Dell', Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garces, Pilar, Goyard, David, Hayward, Hannah, Ham, Lindsay M, Hipp, Joerg, Holt, Rosemary J, Johnson, Mark H, Isaksson, Johan, Kundu, Prantik, Lai, Meng-Chuan, D'ardhuy, Xavier Liogier, Lombardo, Michael V, Lythgoe, David J, Mandl, René, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M, Ruigrok, Amber N V, Ruggeri, Barbara, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C R, Zwiers, Marcel P, Spooren, Will, Murphy, Declan G M, and Buitelaar, Jan K
- Abstract
BACKGROUND: The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pathophysiologically based treatments with stratification biomarkers that predict which treatment may be most beneficial for particular individuals. However, so far, we have no single validated stratification biomarker for ASD. This may be due to the fact that most research studies primarily have focused on the identification of mean case-control differences, rather than within-group variability, and included small samples that were underpowered for stratification approaches. The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study worldwide that aims to identify and validate stratification biomarkers for ASD. METHODS: LEAP includes 437 children and adults with ASD and 300 individuals with typical development or mild intellectual disability. Using an accelerated longitudinal design, each participant is comprehensively characterised in terms of clinical symptoms, comorbidities, functional outcomes, neurocognitive profile, brain structure and function, biochemical markers and genomics. In addition, 51 twin-pairs (of which 36 had one sibling with ASD) are included to identify genetic and environmental factors in phenotypic variability. RESULTS: Here, we describe the demographic characteristics of the cohort, planned analytic stratification approaches, criteria and steps to validate candidate stratification markers, pre-registration procedures to increase transparency, standardisation and data robustness across all analyses, and share some 'lessons learnt'. A clinical characterisation of the cohort is given in the companion paper (Charman et al., accepted). CONCLUSION: We expect that LEAP wil
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- 2017
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36. The EU-AIMS Longitudinal European Autism Project (LEAP) : clinical characterisation.
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Charman, Tony, Loth, Eva, Tillmann, Julian, Crawley, Daisy, Wooldridge, Caroline, Goyard, David, Ahmad, Jumana, Auyeung, Bonnie, Ambrosino, Sara, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian, Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Chakrabarti, Bhismadev, Cornelissen, Ineke, Acqua, Flavio Dell', Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary J, Isaksson, Johan, Johnson, Mark H, Jones, Emily J H, Kundu, Prantik, Lai, Meng-Chuan, D'ardhuy, Xavier Liogier, Lombardo, Michael V, Lythgoe, David J, Mandl, René, Mason, Luke, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M, Ruggeri, Barbara, Ruigrok, Amber N V, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San Jóse, Simonoff, Emily, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C R, Zwiers, Marcel P, Spooren, Will, Murphy, Declan G M, Buitelaar, Jan K, Charman, Tony, Loth, Eva, Tillmann, Julian, Crawley, Daisy, Wooldridge, Caroline, Goyard, David, Ahmad, Jumana, Auyeung, Bonnie, Ambrosino, Sara, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian, Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Chakrabarti, Bhismadev, Cornelissen, Ineke, Acqua, Flavio Dell', Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary J, Isaksson, Johan, Johnson, Mark H, Jones, Emily J H, Kundu, Prantik, Lai, Meng-Chuan, D'ardhuy, Xavier Liogier, Lombardo, Michael V, Lythgoe, David J, Mandl, René, Mason, Luke, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M, Ruggeri, Barbara, Ruigrok, Amber N V, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San Jóse, Simonoff, Emily, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C R, Zwiers, Marcel P, Spooren, Will, Murphy, Declan G M, and Buitelaar, Jan K
- Abstract
BACKGROUND: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ differences in ASD core symptoms and common co-occurring psychiatric symptoms. A companion paper describes the overall design and experimental protocol and outlines the strategy to identify stratification biomarkers. METHODS: From six research centres in four European countries, we recruited 437 children and adults with ASD and 300 controls between the ages of 6 and 30 years with IQs varying between 50 and 148. We conducted in-depth clinical characterisation including a wide range of observational, interview and questionnaire measures of the ASD phenotype, as well as co-occurring psychiatric symptoms. RESULTS: The cohort showed heterogeneity in ASD symptom presentation, with only minimal to moderate site differences on core clinical and cognitive measures. On both parent-report interview and questionnaire measures, ASD symptom severity was lower in adults compared to children and adolescents. The precise pattern of differences varied across measures, but there was some evidence of both lower social symptoms and lower repetitive behaviour severity in adults. Males had higher ASD symptom scores than females on clinician-rated and parent interview diagnostic measures but not on parent-reported dimensional measures of ASD symptoms. In contrast, self-reported ASD symptom severity was higher in adults compared to adolescents, and in adult females compared to males. Higher scores on ASD symptom measures were moderately associated with lower IQ. Both inattentive and hyperactive/impulsive ADHD symptoms were lower in adults than in children and adolescents, and males with ASD had higher levels of inattentive and hyperactive/impulsive ADHD symptoms than females. CONCLUSIONS: The esta
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- 2017
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- View/download PDF
37. The EU-AIMS Longitudinal European Autism Project (LEAP): Design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders
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Ontwikkelingsstoornissen Ond., Brain, Onderzoeksgroep 8, Onderzoek Bob Oranje, Loth, Eva, Charman, Tony, Mason, Luke, Tillmann, Julian, Jones, Emily J.H., Wooldridge, Caroline, Ahmad, Jumana, Auyeung, Bonnie, Brogna, Claudia, Ambrosino, Sara, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian, Brammer, Michael, Brandeis, Daniel, Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, De Bruijn, Yvette, Chakrabarti, Bhismadev, Crawley, Daisy, Cornelissen, Ineke, Acqua, Flavio Dell, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garces, Pilar, Goyard, David, Hayward, Hannah, Ham, Lindsay M., Hipp, Joerg, Holt, Rosemary J., Johnson, Mark H., Isaksson, Johan, Kundu, Prantik, Lai, Meng Chuan, D'Ardhuy, Xavier Liogier, Lombardo, Michael V., Lythgoe, David J, Mandl, René, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruigrok, Amber N V, Ruggeri, Barbara, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Zwiers, Marcel P., Spooren, Will, Murphy, Declan G M, Buitelaar, Jan K., Ontwikkelingsstoornissen Ond., Brain, Onderzoeksgroep 8, Onderzoek Bob Oranje, Loth, Eva, Charman, Tony, Mason, Luke, Tillmann, Julian, Jones, Emily J.H., Wooldridge, Caroline, Ahmad, Jumana, Auyeung, Bonnie, Brogna, Claudia, Ambrosino, Sara, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian, Brammer, Michael, Brandeis, Daniel, Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, De Bruijn, Yvette, Chakrabarti, Bhismadev, Crawley, Daisy, Cornelissen, Ineke, Acqua, Flavio Dell, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garces, Pilar, Goyard, David, Hayward, Hannah, Ham, Lindsay M., Hipp, Joerg, Holt, Rosemary J., Johnson, Mark H., Isaksson, Johan, Kundu, Prantik, Lai, Meng Chuan, D'Ardhuy, Xavier Liogier, Lombardo, Michael V., Lythgoe, David J, Mandl, René, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruigrok, Amber N V, Ruggeri, Barbara, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Zwiers, Marcel P., Spooren, Will, Murphy, Declan G M, and Buitelaar, Jan K.
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- 2017
38. The EU-AIMS Longitudinal European Autism Project (LEAP): Clinical characterisation
- Author
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Ontwikkelingsstoornissen Ond., Brain, Onderzoeksgroep 8, Onderzoek Bob Oranje, Charman, Tony, Loth, Eva, Tillmann, Julian, Crawley, Daisy, Wooldridge, Caroline, Goyard, David, Ahmad, Jumana, Auyeung, Bonnie, Ambrosino, Sara, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian, Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, De Bruijn, Yvette, Chakrabarti, Bhismadev, Cornelissen, Ineke, Acqua, Flavio Dell, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary J., Isaksson, Johan, Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng Chuan, D'Ardhuy, Xavier Liogier, Lombardo, Michael V., Lythgoe, David J, Mandl, René, Mason, Luke, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber N V, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San Jóse, Simonoff, Emily, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Zwiers, Marcel P., Spooren, Will, Murphy, Declan G M, Buitelaar, Jan K., Ontwikkelingsstoornissen Ond., Brain, Onderzoeksgroep 8, Onderzoek Bob Oranje, Charman, Tony, Loth, Eva, Tillmann, Julian, Crawley, Daisy, Wooldridge, Caroline, Goyard, David, Ahmad, Jumana, Auyeung, Bonnie, Ambrosino, Sara, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian, Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, De Bruijn, Yvette, Chakrabarti, Bhismadev, Cornelissen, Ineke, Acqua, Flavio Dell, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary J., Isaksson, Johan, Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng Chuan, D'Ardhuy, Xavier Liogier, Lombardo, Michael V., Lythgoe, David J, Mandl, René, Mason, Luke, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber N V, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San Jóse, Simonoff, Emily, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Zwiers, Marcel P., Spooren, Will, Murphy, Declan G M, and Buitelaar, Jan K.
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- 2017
39. Identification and validation of biomarkers for autism spectrum disorders
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Loth, Eva, Spooren, Will, Ham, Lindsay M., Isaac, Maria B., Auriche-Benichou, Caroline, Banaschewski, Tobias, Baron-Cohen,Simon, Broich, Karl, Boelte, Sven, Bourgeron, Thomas, Charman, Tony, Collier, David, de Andres-Trelles, Fernando, Durston, Sarah, Ecker, Christine, Elferink, Andre, Haberkamp, Marion, Hemmings, Robert, Johnson, Mark H., Jones, Emily J. H., Khwaja, Omar S., Lenton, Sabine, Mason, Luke, Mantua, Valentina, Meyer-Lindenberg, Andreas, Lombardo, Michael V., O'Dwyer, Laurence, Okamoto, Koichi, Pandina, Gahan J., Pani, Luca, Persico, Antonio M., Simonoff, Emily, Tauscher-Wisniewski, Sitra, Llinares-Garcia, Jordi, Vamvakas, Spiros, Williams,Steven C. R., Buitelaar, Jan K., Murphy,Declan G. M., Lombardo,Michael V., and Lombardo, Michael V. [0000-0001-6780-8619]
- Abstract
Autism spectrum disorder (ASD) is one of the most common neurodevelopmental disorders, but effective medical treatments for the core symptoms of the disorder are still lacking. According to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), the core symptoms of ASD comprise deficits in social communication and interaction, and repetitive and restricted behaviours, which include sensory abnormalities. Novel genetic and preclinical approaches now provide unprecedented opportunities to identify the underpinning pathophysiological mechanisms and aetiology-based treatment targets, as discussed in a Review article by Ghosh et al. (Drug discovery for autism spectrum disorder: challenges and opportunities. Nat. Rev. Drug Discov. 12, 777–790 (2013)1. This has led to more interest from the pharmaceutical industry in an area in which the overall risk of failure is seen as very high because key parameters of drug efficiency are not yet established and the regulatory environment is uncertain. For example, industry has recently invested in several pre-competitive projects, such as the European Union (EU) Innovative Medicines Initiative (IMI)-brokered public–private partnership EU-AIMS (European Autism Interventions — A Multicentre Study for Developing New Medications)2. 15 1 70 73 PT: J
- Published
- 2016
40. Linear assemblies of magnetic nanoparticles as MRI contrast agents
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Corr, Serena A., Byrne, Stephen J., Tekoriute, Renata, Meledandri, Carla J., Brougham, Dermot F., Lynch, Marina, Kerskens, Christian, O'Dwyer, Laurence, and Gun'ko, Yurii K.
- Subjects
Magnetic fluids -- Properties ,Magnetic resonance imaging -- Analysis ,Nanoparticles -- Magnetic properties ,Nanoparticles -- Optical properties ,X-rays -- Diffraction ,X-rays -- Observations ,Chemistry - Abstract
The article describes a one-step procedure to prepare magnetic fluids comprised of polyelectrolyte stabilized magnetic nanoparticles, which exhibit good biocompatibility and potential for in vivo MRI diagnostics. The new magnetic fluids can also be applied to prepare various flexible linear assemblies of magnetic nanoparticles with number of important potential applications in chemistry, biology, and medicine.
- Published
- 2008
41. Supporting Innovation through Regulation and Science: Ireland as an Innovation Hub for Health Products
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O'Dwyer, Laurence, primary, Nolan, Lorraine, additional, and Fisher, Caitriona, additional
- Published
- 2017
- Full Text
- View/download PDF
42. The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders
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Loth, Eva, primary, Charman, Tony, additional, Mason, Luke, additional, Tillmann, Julian, additional, Jones, Emily J. H., additional, Wooldridge, Caroline, additional, Ahmad, Jumana, additional, Auyeung, Bonnie, additional, Brogna, Claudia, additional, Ambrosino, Sara, additional, Banaschewski, Tobias, additional, Baron-Cohen, Simon, additional, Baumeister, Sarah, additional, Beckmann, Christian, additional, Brammer, Michael, additional, Brandeis, Daniel, additional, Bölte, Sven, additional, Bourgeron, Thomas, additional, Bours, Carsten, additional, de Bruijn, Yvette, additional, Chakrabarti, Bhismadev, additional, Crawley, Daisy, additional, Cornelissen, Ineke, additional, Acqua, Flavio Dell’, additional, Dumas, Guillaume, additional, Durston, Sarah, additional, Ecker, Christine, additional, Faulkner, Jessica, additional, Frouin, Vincent, additional, Garces, Pilar, additional, Goyard, David, additional, Hayward, Hannah, additional, Ham, Lindsay M., additional, Hipp, Joerg, additional, Holt, Rosemary J., additional, Johnson, Mark H., additional, Isaksson, Johan, additional, Kundu, Prantik, additional, Lai, Meng-Chuan, additional, D’ardhuy, Xavier Liogier, additional, Lombardo, Michael V., additional, Lythgoe, David J., additional, Mandl, René, additional, Meyer-Lindenberg, Andreas, additional, Moessnang, Carolin, additional, Mueller, Nico, additional, O’Dwyer, Laurence, additional, Oldehinkel, Marianne, additional, Oranje, Bob, additional, Pandina, Gahan, additional, Persico, Antonio M., additional, Ruigrok, Amber N. V., additional, Ruggeri, Barbara, additional, Sabet, Jessica, additional, Sacco, Roberto, additional, Cáceres, Antonia San José, additional, Simonoff, Emily, additional, Toro, Roberto, additional, Tost, Heike, additional, Waldman, Jack, additional, Williams, Steve C. R., additional, Zwiers, Marcel P., additional, Spooren, Will, additional, Murphy, Declan G. M., additional, and Buitelaar, Jan K., additional
- Published
- 2017
- Full Text
- View/download PDF
43. Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project
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Oldehinkel, Marianne, Mennes, Maarten, Marquand, Andre, Charman, Tony, Tillmann, Julian, Ecker, Christine, Dell’Acqua, Flavio, Brandeis, Daniel, Banaschewski, Tobias, Baumeister, Sarah, Moessnang, Carolin, Baron-Cohen, Simon, Holt, Rosemary, Bölte, Sven, Durston, Sarah, Kundu, Prantik, Lombardo, Michael V., Spooren, Will, Loth, Eva, Murphy, Declan G.M., Beckmann, Christian F., Buitelaar, Jan K., Ahmad, Jumana, Ambrosino, Sara, Auyeung, Bonnie, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian F., Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, de Bruijn, Yvette, Buitelaar, Jan K., Chakrabarti, Bhismadev, Charman, Tony, Cornelissen, Ineke, Crawley, Daisy, Dell’Acqua, Flavio, Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garcés, Pilar, Goyard, David, Ham, Lindsay, Hayward, Hannah, Hipp, Joerg, Holt, Rosemary, Johnson, Mark H., Jones, Emily J.H., Kundu, Prantik, Lai, Meng-Chuan, Liogier D’ardhuy, Xavier, Lombardo, Michael V., Loth, Eva, Lythgoe, David J., Mandl, René, Marquand, Andre, Mason, Luke, Mennes, Maarten, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, Murphy, Declan G.M., Oakley, Bethany, O’Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M., Ruggeri, Barbara, Ruigrok, Amber, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Spooren, Will, Tillmann, Julian, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C.R., Wooldridge, Caroline, and Zwiers, Marcel P.
- Abstract
Resting-state functional magnetic resonance imaging–based studies on functional connectivity in autism spectrum disorder (ASD) have generated inconsistent results. Interpretation of findings is further hampered by small samples and a focus on a limited number of networks, with networks underlying sensory processing being largely underexamined. We aimed to comprehensively characterize ASD-related alterations within and between 20 well-characterized resting-state networks using baseline data from the EU-AIMS (European Autism Interventions—A Multicentre Study for Developing New Medications) Longitudinal European Autism Project.
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- 2024
- Full Text
- View/download PDF
44. Decreased Left Caudate Volume Is Associated with Increased Severity of Autistic-Like Symptoms in a Cohort of ADHD Patients and Their Unaffected Siblings
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O’Dwyer, Laurence, primary, Tanner, Colby, additional, van Dongen, Eelco V., additional, Greven, Corina U., additional, Bralten, Janita, additional, Zwiers, Marcel P., additional, Franke, Barbara, additional, Heslenfeld, Dirk, additional, Oosterlaan, Jaap, additional, Hoekstra, Pieter J., additional, Hartman, Catharina A., additional, Groen, Wouter, additional, Rommelse, Nanda, additional, and Buitelaar, Jan K., additional
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- 2016
- Full Text
- View/download PDF
45. Identification and validation of biomarkers for autism spectrum disorders
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Loth, Eva, primary, Spooren, Will, additional, Ham, Lindsay M., additional, Isaac, Maria B., additional, Auriche-Benichou, Caroline, additional, Banaschewski, Tobias, additional, Baron-Cohen, Simon, additional, Broich, Karl, additional, Bölte, Sven, additional, Bourgeron, Thomas, additional, Charman, Tony, additional, Collier, David, additional, de Andres-Trelles, Fernando, additional, Durston, Sarah, additional, Ecker, Christine, additional, Elferink, Andre, additional, Haberkamp, Marion, additional, Hemmings, Robert, additional, Johnson, Mark H., additional, Jones, Emily J. H., additional, Khwaja, Omar S., additional, Lenton, Sabine, additional, Mason, Luke, additional, Mantua, Valentina, additional, Meyer-Lindenberg, Andreas, additional, Lombardo, Michael V., additional, O'Dwyer, Laurence, additional, Okamoto, Koichi, additional, Pandina, Gahan J., additional, Pani, Luca, additional, Persico, Antonio M., additional, Simonoff, Emily, additional, Tauscher-Wisniewski, Sitra, additional, Llinares-Garcia, Jordi, additional, Vamvakas, Spiros, additional, Williams, Steve, additional, Buitelaar, Jan K., additional, and Murphy, Declan G. M., additional
- Published
- 2015
- Full Text
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46. Distinct effects of ASD and ADHD symptoms on reward anticipation in participants with ADHD, their unaffected siblings and healthy controls: a cross-sectional study
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van Dongen, Eelco V., primary, von Rhein, Daniel, additional, O’Dwyer, Laurence, additional, Franke, Barbara, additional, Hartman, Catharina A., additional, Heslenfeld, Dirk J., additional, Hoekstra, Pieter J., additional, Oosterlaan, Jaap, additional, Rommelse, Nanda, additional, and Buitelaar, Jan, additional
- Published
- 2015
- Full Text
- View/download PDF
47. White matter microstructure and developmental improvement of hyperactive/impulsive symptoms in attention-deficit/hyperactivity disorder
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Francx, Winke, primary, Zwiers, Marcel P., additional, Mennes, Maarten, additional, Oosterlaan, Jaap, additional, Heslenfeld, Dirk, additional, Hoekstra, Pieter J., additional, Hartman, Catharina A., additional, Franke, Barbara, additional, Faraone, Stephen V., additional, O'Dwyer, Laurence, additional, and Buitelaar, Jan K., additional
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- 2015
- Full Text
- View/download PDF
48. Brain Volumetric Correlates of Autism Spectrum Disorder Symptoms in Attention Deficit/Hyperactivity Disorder
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O’Dwyer, Laurence, primary, Tanner, Colby, additional, van Dongen, Eelco V., additional, Greven, Corina U., additional, Bralten, Janita, additional, Zwiers, Marcel P., additional, Franke, Barbara, additional, Oosterlaan, Jaap, additional, Heslenfeld, Dirk, additional, Hoekstra, Pieter, additional, Hartman, Catharina A., additional, Rommelse, Nanda, additional, and Buitelaar, Jan K., additional
- Published
- 2014
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- View/download PDF
49. Differential effects of the ApoE4 genotype on brain structure and function
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Matura, Silke, primary, Prvulovic, David, additional, Jurcoane, Alina, additional, Hartmann, Daniel, additional, Miller, Julia, additional, Scheibe, Monika, additional, O'Dwyer, Laurence, additional, Oertel-Knöchel, Viola, additional, Knöchel, Christian, additional, Reinke, Britta, additional, Karakaya, Tarik, additional, Fußer, Fabian, additional, and Pantel, Johannes, additional
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- 2014
- Full Text
- View/download PDF
50. Different patterns of white matter degeneration using multiple diffusion indices and volumetric data in mild cognitive impairment and Alzheimer patients
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Alves, Gilberto Sousa, O’Dwyer, Laurence, Jurcoane, Alina, Oertel-Knöchel, Viola, Knöchel, Christian, Prvulovic, David, Sudo, Felipe, Alves, Carlos Eduardo, Valente, Letice, Moreira, Denise, Fußer, Fabian, Karakaya, Tarik, Pantel, Johannes, Engelhardt, Eliasz, Laks, Jerson, Alves, Gilberto Sousa, O’Dwyer, Laurence, Jurcoane, Alina, Oertel-Knöchel, Viola, Knöchel, Christian, Prvulovic, David, Sudo, Felipe, Alves, Carlos Eduardo, Valente, Letice, Moreira, Denise, Fußer, Fabian, Karakaya, Tarik, Pantel, Johannes, Engelhardt, Eliasz, and Laks, Jerson
- Abstract
Alzheimeŕs disease (AD) represents the most prevalent neurodegenerative disorder that causes cognitive decline in old age. In its early stages, AD is associated with microstructural abnormalities in white matter (WM). In the current study, multiple indices of diffusion tensor imaging (DTI) and brain volumetric measurements were employed to comprehensively investigate the landscape of AD pathology. The sample comprised 58 individuals including cognitively normal subjects (controls), amnestic mild cognitive impairment (MCI) and AD patients. Relative to controls, both MCI and AD subjects showed widespread changes of anisotropic fraction (FA) in the corpus callosum, cingulate and uncinate fasciculus. Mean diffusivity and radial changes were also observed in AD patients in comparison with controls. After controlling for the gray matter atrophy the number of regions of significantly lower FA in AD patients relative to controls was decreased; nonetheless, unique areas of microstructural damage remained, e.g., the corpus callosum and uncinate fasciculus. Despite sample size limitations, the current results suggest that a combination of secondary and primary degeneration occurrs in MCI and AD, although the secondary degeneration appears to have a more critical role during the stages of disease involving dementia.
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- 2012
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