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7,948 results on '"O'Brien, Tim"'

2. Low-frequency radio observations of recurrent nova RS Ophiuchi with MeerKAT and LOFAR

Author

de Ruiter, Iris, Nyamai, Miriam M., Rowlinson, Antonia, Wijers, Ralph A. M. J., O'Brien, Tim J., Williams, David R. A., and Woudt, Patrick

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics
Abstract

We report low-frequency radio observations of the 2021 outburst of the recurrent nova RS Ophiuchi. These observations include the lowest frequency observations of this system to date. Detailed light curves are obtained by MeerKAT at 0.82 and 1.28 GHz and LOFAR at 54 and 154 MHz. These low-frequency detections allow us to put stringent constraints on the brightness temperature that clearly favour a non-thermal emission mechanism. The radio emission is interpreted and modelled as synchrotron emission from the shock interaction between the nova ejecta and the circumbinary medium. The light curve shows a plateauing behaviour after the first peak, which can be explained by either a non-uniform density of the circumbinary medium or a second emission component. Allowing for a second component in the light-curve modelling captures the steep decay at late times. Furthermore, extrapolating this model to 15 yr after the outburst shows that the radio emission might not fully disappear between outbursts. Further modelling of the light curves indicates a red giant mass-loss rate of $\sim 5 \cdot 10^{-8}~{\rm M_\odot~yr^{-1}}$. The spectrum cannot be modelled in detail at this stage, as there are likely at least four emission components. Radio emission from stellar wind or synchrotron jets is ruled out as the possible origin of the radio emission. Finally, we suggest a strategy for future observations that would advance our understanding of the physical properties of RS Ophiuchi., Comment: Published in MNRAS

Published
2023
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6. Wellbeing: How We Make Sense of It and What This Means for Teachers

Author

O'Brien, Tim and Guiney, Dennis

Abstract

In this paper, the authors discuss their grounded research carried out with teachers about the wellbeing of teachers. They explore the importance of making the concept of wellbeing more intimate and consider hedonic and eudaimonic ways of looking at wellbeing. They present a model of layered reflection which illuminates key factors that have an impact on the wellbeing of teachers.

Published
2021
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7. Epidemiology of Renal Cell Carcinoma: 2022 Update

Author

Bukavina, Laura, Bensalah, Karim, Bray, Freddie, Carlo, Maria, Challacombe, Ben, Karam, Jose A., Kassouf, Wassim, Mitchell, Thomas, Montironi, Rodolfo, O'Brien, Tim, Panebianco, Valeria, Scelo, Ghislaine, Shuch, Brian, van Poppel, Hein, Blosser, Christopher D., and Psutka, Sarah P.

Published
2022
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8. Has Inclusion Become a Barrier to Inclusion?

Author

O'Brien, Tim

Abstract

In this reflective piece the author focuses on the meaning that he made of inclusion in a book that was published almost twenty years ago. He then reflects on the meaning he makes of the current situation. He explores the problematic nature of the concept of inclusion, whether labels actually enable inclusion, research-informed implications of inclusion for those who do not experience SEND and the damaging impact of hyperaccountability and marketisation. He proposes that we may find future solutions by embracing complexities and educating for diversities.

Published
2020
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9. Scaling up area-based conservation to implement the Global Biodiversity Framework’s 30x30 target: The role of Nature’s Strongholds

Author

Robinson, John G., primary, LaBruna, Danielle, additional, O’Brien, Tim, additional, Clyne, Peter J., additional, Dudley, Nigel, additional, Andelman, Sandy J., additional, Bennett, Elizabeth L., additional, Chicchon, Avecita, additional, Durigan, Carlos, additional, Grantham, Hedley, additional, Kinnaird, Margaret, additional, Lieberman, Sue, additional, Maisels, Fiona, additional, Moreira, Adriana, additional, Rao, Madhu, additional, Stokes, Emma, additional, Walston, Joe, additional, and Watson, James EM, additional

Published
2024
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10. PD48-04 DOES ENHANCED AUDIT AND FEEDBACK WITH EDUCATION IMPROVE QUALITY INDICATOR (QI) ACHIEVEMENT AND REDUCE EARLY RECURRENCE RATES IN TURBT SURGERY FOR NMIBC? RESULTS FROM THE RESECT CLUSTER RANDOMISED TRIAL

Author

Gaba, Fortis, primary, Gallagher, Kevin, additional, Bhatt, Nikita, additional, Clement, Keiran, additional, Zimmermann, Eleanor, additional, Khadhouri, Sinan, additional, Kulkarni, Meghana, additional, Anbarasan, Thines, additional, Ng, Alexander, additional, Light, Alexander, additional, Asif, Aqua, additional, Chan, Vinson, additional, Nathan, Arjun, additional, Rossi, Sabrina, additional, Geng, Wendy, additional, Cooper, David, additional, Aucott, Lorna, additional, O’Brien, Tim, additional, MacLennan, Steven, additional, Nielsen, Matthew, additional, Mariappan, Paramananthan, additional, and Kasivisvanathan, Veeru, additional

Published
2024
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11. Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study

Author

Fu, Xiao, Zhao, Yue, Lopez, Jose I., Rowan, Andrew, Au, Lewis, Fendler, Annika, Hazell, Steve, Xu, Hang, Horswell, Stuart, Shepherd, Scott T. C., Spencer, Charlotte E., Spain, Lavinia, Byrne, Fiona, Stamp, Gordon, O’Brien, Tim, Nicol, David, Augustine, Marcellus, Chandra, Ashish, Rudman, Sarah, Toncheva, Antonia, Furness, Andrew J. S., Pickering, Lisa, Kumar, Santosh, Koh, Dow-Mu, Messiou, Christina, Dafydd, Derfel ap, Orton, Matthew R., Doran, Simon J., Larkin, James, Swanton, Charles, Sahai, Erik, Litchfield, Kevin, Turajlic, Samra, and Bates, Paul A.

Published
2022
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12. Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma

Author

Abbosh, Chris, Shiu, Kai-Keen, Bridgewater, John, Hochhauser, Daniel, Forster, Martin, Lee, Siow-Ming, Ahmad, Tanya, Papadatos-Pastos, Dionysis, Janes, Sam, Van Loo, Peter, Enfield, Katey, McGranahan, Nicholas, Huebner, Ariana, Beck, Stephan, Parker, Peter, Walczak, Henning, Enver, Tariq, Hynds, Rob, Sinclair, Ron, Lok, Chi-wah, Rhodes, Zoe, Moore, David, Khiroya, Reena, Trevisan, Giorgia, Ellery, Peter, Linch, Mark, Brandner, Sebastian, Hiley, Crispin, Veeriah, Selvaraju, Razaq, Maryam, Shaw, Heather, Attard, Gert, Akther, Mita Afroza, Naceur-Lombardelli, Cristina, Manzano, Lizi, Al-Bakir, Maise, Summan, Simranpreet, Kanu, Nnenna, Ward, Sophie, Asghar, Uzma, Lim, Emilia, Gishen, Faye, Tookman, Adrian, Stone, Paddy, Stirling, Caroline, Hunter, Nikki, Vaughan, Sarah, Mangwende, Mary, Spain, Lavinia, Yan, Haixi, Shum, Ben, Carlyle, Eleanor, Yousaf, Nadia, Popat, Sanjay, Curtis, Olivia, Stamp, Gordon, Toncheva, Antonia, Nye, Emma, Murra, Aida, Korteweg, Justine, Josephs, Debra, Chandra, Ashish, Spicer, James, Stewart, Ruby, Iredale, Lara-Rose, Mackay, Tina, Deakin, Ben, Enting, Debra, Rudman, Sarah, Ghosh, Sharmistha, Karapagniotou, Lena, Pintus, Elias, Tutt, Andrew, Howlett, Sarah, Michalarea, Vasiliki, Brenton, James, Caldas, Carlos, Fitzgerald, Rebecca, Jimenez-Linan, Merche, Provenzano, Elena, Cluroe, Alison, Stewart, Grant, Watts, Colin, Gilbertson, Richard, McDermott, Ultan, Tavare, Simon, Beddowes, Emma, Roxburgh, Patricia, Biankin, Andrew, Chalmers, Anthony, Fraser, Sioban, Oien, Karin, Kidd, Andrew, Blyth, Kevin, Krebs, Matt, Blackhall, Fiona, Summers, Yvonne, Dive, Caroline, Marais, Richard, Gomes, Fabio, Carter, Mat, Dransfield, Jo, Le Quesne, John, Fennell, Dean, Shaw, Jacqui, Naidu, Babu, Baijal, Shobhit, Tanchel, Bruce, Langman, Gerald, Robinson, Andrew, Collard, Martin, Cockcroft, Peter, Ferris, Charlotte, Bancroft, Hollie, Kerr, Amy, Middleton, Gary, Webb, Joanne, Kadiri, Salma, Colloby, Peter, Olisemeke, Bernard, Wilson, Rodelaine, Tomlinson, Ian, Jogai, Sanjay, Ottensmeier, Christian, Harrison, David, Loda, Massimo, Flanagan, Adrienne, McKenzie, Mairead, Hackshaw, Allan, Ledermann, Jonathan, Chan, Kitty, Sharp, Abby, Farrelly, Laura, Bridger, Hayley, Challacombe, Ben, Chowdhury, Simon, Drake, William, Fernando, Archana, Harrison-Phipps, Karen, Hazell, Steve, Hill, Peter, Horsfield, Catherine, O'Brien, Tim, Olsburgh, Jonathon, Polson, Alexander, Varia, Mary, Verma, Hema, Au, Lewis, Hatipoglu, Emine, Robert de Massy, Marc, Litchfield, Kevin, Beattie, Gordon, Rowan, Andrew, Schnidrig, Desiree, Thompson, Rachael, Byrne, Fiona, Horswell, Stuart, Fotiadis, Nicos, Nicol, David, Shepherd, Scott T.C., Fendler, Annika, Mason, Robert, Del Rosario, Lyra, Edmonds, Kim, Lingard, Karla, Sarker, Sarah, Attig, Jan, Joshi, Kroopa, Uddin, Imran, Becker, Pablo D., Sunderland, Mariana Werner, Akarca, Ayse, Puccio, Ignazio, Yang, William W., Lund, Tom, Dhillon, Kim, Vasquez, Marcos Duran, Ghorani, Ehsan, Xu, Hang, Spencer, Charlotte, López, José I., Green, Anna, Mahadeva, Ula, Borg, Elaine, Mitchison, Miriam, Moore, David A., Proctor, Ian, Falzon, Mary, Pickering, Lisa, Furness, Andrew J.S., Reading, James L., Salgado, Roberto, Marafioti, Teresa, Jamal-Hanjani, Mariam, Kassiotis, George, Chain, Benny, Larkin, James, Swanton, Charles, Quezada, Sergio A., and Turajlic, Samra

Published
2021
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13. VLBI detection of internal shocks in nova V959 Mon

Author

Yang, Jun, Paragi, Zsolt, O'Brien, Tim J., Chomiuk, Laura, and Linford, Justin D.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

V959 Mon is a classical nova detected at GeV gamma-ray wavelengths on 2012 June 19. While classical novae are now routinely detected in gamma-rays, the origin of the shocks that produce relativistic particles has remained unknown. We carried out electronic European VLBI Network (e-EVN) observations that revealed a pair of compact synchrotron emission features in V959 Mon on 2012 Sep 18. Since synchrotron emission requires strong shocks as well, we identify these features as the location where the gamma rays were produced. We also detected the extended ejecta in the follow-up EVN observations. They expanded much faster in East-West direction than the compact knots detected in the aforementioned e-EVN measurements. By comparing the VLBI results with lower resolution images obtained using e-MERLIN and the VLA - as reported by Chomiuk et al. (2014) - it appears that 1) influenced by the binary orbit, the nova ejecta was highly asymmetric with a dense and slow outflow in the equatorial plane and low-density and faster ejecta along the poles; and 2) the VLBI knots were related to shocks formed in the interaction region of these outflows., Comment: 6 pages, 2 figures, To be published in PoS, 12th EVN Symposium and Users Meeting, 7-10 Oct 2014, Cagliari, Italy

Published
2015

14. Thermal radio emission from novae & symbiotics with the Square Kilometre Array

Author

O'Brien, Tim, Rupen, Michael, Chomiuk, Laura, Ribeiro, Valerio, Bode, Michael, Sokoloski, Jennifer, and Woudt, Patrick

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The thermal radio emission of novae during outburst enables us to derive fundamental quantities such as the ejected mass, kinetic energy, and density profile of the ejecta. Recent observations with newly-upgraded facilities such as the VLA and e-MERLIN are just beginning to reveal the incredibly complex processes of mass ejection in novae (ejections appear to often proceed in multiple phases and over prolonged timescales). Symbiotic stars can also exhibit outbursts, which are sometimes accompanied by the expulsion of material in jets. However, unlike novae, the long-term thermal radio emission of symbiotics originates in the wind of the giant secondary star, which is irradiated by the hot white dwarf. The effect of the white dwarf on the giant's wind is strongly time variable, and the physical mechanism driving these variations remains a mystery (possibilities include accretion instabilities and time-variable nuclear burning on the white dwarf's surface). The exquisite sensitivity of SKA1 will enable us to survey novae throughout the Galaxy, unveiling statistically complete populations. With SKA2 it will be possible to carry out similar studies in the Magellanic Clouds. This will enable high-quality tests of the theory behind accretion and mass loss from accreting white dwarfs, with significant implications for determining their possible role as Type Ia supernova progenitors. Observations with SKA1-MID in particular, over a broad range of frequencies, but with emphasis on the higher frequencies, will provide an unparalleled view of the physical processes driving mass ejection and resulting in the diversity of novae, whilst also determining the accretion processes and rates in symbiotic stars., Comment: 13 pages, 3 figures, in proceedings of "Advancing Astrophysics with the Square Kilometre Array", PoS(AASKA14)116, in press

Published
2015

15. A Domains-Based Approach to Meeting Social, Emotional and Mental Health Needs

Author

O'Brien, Tim and Roberts, Amelia

Abstract

This article focuses on seven interacting research-informed domains. These domains are grounded in the research literature and have been applied in real world contexts to provide insight into, and an analytical tool for, meeting social, emotional and mental health (SEMH) needs within educational settings. Practitioner researchers applied the domains in a ten-month knowledge-exchange programme known as SWERL. Each domain is described in relation to the lived experience of teachers, pupils and schools. The article closes with a case study of how a primary school changed SEMH provision in the areas of 'planning transitions' and 'building relationships' and illuminates the benefits for children, staff and school culture.

Published
2019
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17. Ten-year Mortality, Disease Progression, and Treatment-related Side Effects in Men with Localised Prostate Cancer from the ProtecT Randomised Controlled Trial According to Treatment Received

Author

Hamdy, Freddie C., Donovan, Jenny L., Neal, David E., Lane, J. Athene, Metcalfe, Chris, Peters, Tim J., Bollina, Prasad, Doble, Andrew, Doherty, Alan, Gnanapragasam, Vincent, Hughes, Owen, Gillatt, David, Kockelbergh, Roger, Kynaston, Howard, Paul, Alan, Paez, Edgar, Powell, Philip, Prescott, Stephen, Rosario, Derek, Rowe, Edward, Anderson, John B., Aning, Jonathan, Catto, James, Durkan, Garett, Koupparis, Anthony, Leung, Hing, Mariappan, Param, McNeill, Alan, Persad, Raj, Schwaibold, Hartwig, Tulloch, David, Wallace, Michael, Bonnington, Susan, Bradshaw, Lynne, Cooper, Deborah, Elliott, Emma, Herbert, Phillipa, Holding, Peter, Howson, Joanne, Jones, Amanda, Lennon, Teresa, Lyons, Norma, Moody, Hilary, Plumb, Claire, O'Sullivan, Tricia, Salter, Elizabeth, Thompson, Pauline, Tidball, Sarah, Blaikie, Jan, Gray, Catherine, Adam, Tonia, Askew, Sarah, Atkinson, Sharon, Baynes, Tim, Brain, Carole, Breen, Viv, Brunt, Sarah, Bryne, Sean, Bythem, Jo, Clarke, Jenny, Cloete, Jenny, Dark, Susan, Davis, Gill, Rue, Rachael De La, Denizot, Jane, Dewhurst, Elspeth, Dimes, Anna, Dixon, Nicola, Ebbs, Penny, Emmerson, Ingrid, Ferguson, Jill, Gadd, Ali, Geoghegan, Lisa, Grant, Alison, Grant, Collette, Godfrey, Rosemary, Goodwin, Louise, Hall, Susie, Hart, Liz, Harvey, Andrew, Hoult, Chloe, Hawkins, Sarah, Holling, Sharon, Innes, Alastair, Kilner, Sue, Marshall, Fiona, Mellen, Louise, Moore, Andrea, Napier, Sally, Needham, Julie, Pearse, Kevin, Pisa, Anna, Rees, Mark, Richards, Ellie, Robson, Lindsay, Roxburgh, Janet, Samuel, Nikki, Sharkey, Irene, Slater, Michael, Smith, Donna, Taggart, Pippa, Taylor, Helen, Taylor, Vicky, Thomas, Ayesha, Tomkies, Briony, Trewick, Nicola, Ward, Claire, Walker, Christy, Williams, Ayesha, Woodhouse, Colin, Wyber, Elizabeth, Mason, Malcolm, Bahl, Amit, Benson, Richard, Beresford, Mark, Ferguson, Catherine, Graham, John, Herbert, Chris, Howard, Grahame, James, Nick, Kirkbride, Peter, Law, Alastair, Loughrey, Carmel, McClaren, Duncan, Patterson, Helen, Pedley, Ian, Roberts, Trevor, Robinson, Angus, Russell, Simon, Staffurth, John, Symonds, Paul, Thanvi, Narottam, Vasanthan, Subramaniam, Wilson, Paula, Oxley, Jon, Robinson, Mary, Bhattarai, Selina, Deshmukh, Neeta, Dormer, John, Fernando, Malee, Goepel, John, Griffiths, David, Grigor, Ken, Mayer, Nick, Varma, Murali, Warren, Anne, Appleby, Helen, Ash, Dominic, Aston, Dean, Bolton, Steven, Chalmers, Graham, Conway, John, Early, Nick, Geater, Tony, Goddall, Lynda, Heymann, Claire, Hicks, Deborah, Jones, Liza, Lamb, Susan, Lambert, Geoff, Lawrence, Gill, Lewis, Geraint, Lilley, John, MacLeod, Aileen, Massey, Pauline, McQueen, Alison, Moore, Rollo, Penketh, Lynda, Potterton, Janet, Roberts, Neil, Showler, Helen, Shuttleworth, Pam, Slade, Stephen, Steele, Alasdair, Swinscoe, James, Tiffany, Marie, Townley, John, Treeby, Jo, Weston, Michael, Wilkinson, Joyce, Williams, Lorraine, Wills, Lucy, Woodley, Owain, Yarrow, Sue, Brindle, Lucy, Davies, Linda, Davis, Michael, Dedman, Dan, Down, Elizabeth, Khazragui, Hanan, Martin, Richard M., Noble, Sian, Taylor, Hilary, Tazewell, Marta, Turner, Emma L., Wade, Julia, Walsh, Eleanor, Baker, Susan, Bellis-Sheldon, Elizabeth, Bougard, Chantal, Bowtell, Joanne, Brewer, Catherine, Burton, Chris, Charlton, Jennie, Christoforou, Nicholas, Clark, Rebecca, Coull, Susan, Croker, Christine, Currer, Rosemary, Daisey, Claire, Delaney, Gill, Donohue, Rose, Drew, Jane, Farmer, Rebecca, Fry, Susan, Haddow, Jean, Hale, Alex, Halpin, Susan, Harris, Belle, Hattrick, Barbara, Holmes, Sharon, Hunt, Helen, Jackson, Vicky, Johnson, Donna, Le Butt, Mandy, Leworthy, Jo, Liddiatt, Tanya, Martin, Alex, Mauree, Jainee, Moore, Susan, Moulam, Gill, Mutch, Jackie, Parker, Kathleen, Pawsey, Christopher, Purdie, Michelle, Robson, Teresa, Smith, Lynne, Stenton, Carole, Steuart-Feilding, Tom, Stott, Beth, Sully, Chris, Sutton, Caroline, Torrington, Carol, Wilkins, Zoe, Williams, Sharon, Wilson, Andrea, Weaver, Ashleigh, Albertsen, Peter, Adolfsson, Jan, Baum, Michael, McFarlane, Jon, Reid, Colette, Turner, Emma, Zietman, Anthony, Hill, Elizabeth, Ng, Siaw Yein, Williams, Naomi, Toole, Jessica, Davies, Charlotte, Hughes, Laura, Rowlands, Mari-Anne, Bell, Lindsey, Harrison, Sean, Mauree, Jainnee, Grant, Adrian, Roberts, Ian, Ashby, Deborah, Cowan, Richard, Fayers, Peter, Mellon, Killian, N’Dow, James, O’Brien, Tim, Sokhal, Michael, Dearnaley, David, Schröder, Fritz, Roberts, Tracy, Young, Grace J., Dutton, Susan J., Walsh, Eleanor I., Peters, Tim. J., Bryant, Richard, Rosario, Derek J., and Altman, Doug G.

Published
2020
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18. Altered lipid homeostasis is associated with cerebellar neurodegeneration in SNX14 deficiency

Author

Zhou, Yijing, primary, Sanchez, Vanessa B., additional, Xu, Peining, additional, Roule, Thomas, additional, Flores-Mendez, Marco, additional, Ciesielski, Brianna, additional, Yoo, Donna, additional, Teshome, Hiab, additional, Jimenez, Teresa, additional, Liu, Shibo, additional, Henne, Mike, additional, O’Brien, Tim, additional, He, Ye, additional, Mesaros, Clementina, additional, and Akizu, Naiara, additional

Published
2024
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19. Tim O'Brien To Release First Novel in 20 Years

Author

O'Brien, Tim

Subjects
Literary prizes
Abstract

Award-winning author Tim O'Brien is set to release his first novel in more than two decades. Mariner announced it will publish O'Brien's America Fantastica this fall. The press describes the [...]

Published
2023

20. Very Long Baseline Interferometry with the SKA

Author

Paragi, Zsolt, Godfrey, Leith, Reynolds, Cormac, Rioja, Maria, Deller, Adam, Zhang, Bo, Gurvits, Leonid, Bietenholz, Michael, Szomoru, Arpad, Bignall, Hayley, Boven, Paul, Charlot, Patrick, Dodson, Richard, Frey, Sandor, Garrett, Michael, Imai, Hiroshi, Lobanov, Andrei, Reid, Mark, Ros, Eduardo, van Langevelde, Huib, Zensus, J. Anton, Zheng, Xing Wu, Alberdi, Antxon, Agudo, Ivan, An, Tao, Argo, Megan, Beswick, Rob, Biggs, Andy D., Brunthaler, Andreas, Campbell, Robert M., Cimo, Giuseppe, Colomer, Francisco, Corbel, Stephane, Conway, John, Cseh, David, Deane, Roger, Falcke, Heino, Gabanyi, Krisztina, Gawronski, Marcin, Gaylard, Michael, Giovannini, Gabriele, Giroletti, Marcello, Goddi, Ciriaco, Goedhart, Sharmila, Gomez, Jose L., Gunn, Alastair, Jung, Taehyun, Kharb, Preeti, Klockner, Hans-Rainer, Kording, Elmar, Kovalev, Yurii Yu., Kunert-Bajraszewska, Magdalena, Lindqvist, Michael, Lister, Matt, Mantovani, Franco, Marti-Vidal, Ivan, Mezcua, Mar, McKean, John, Middelberg, Enno, Miller-Jones, James, Moldon, Javier, Muxlow, Tom, O'Brien, Tim, Pérez-Torres, Miguel, Pogrebenko, Sergei, Quick, Jonathan, Rushton, Anthony P., Schilizzi, Richard, Smirnov, Oleg, Sohn, Bong Won, Surcis, Gabriele, Taylor, Greg, Tingay, Steven, Tudose, Valeriu, van der Horst, Alexander, van Leeuwen, Joeri, Venturi, Tiziana, Vermeulen, Rene, Vlemmings, Wouter, de Witt, Aletha, Wucknitz, Olaf, and Yang, Jun

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics
Abstract

Adding VLBI capability to the SKA arrays will greatly broaden the science of the SKA, and is feasible within the current specifications. SKA-VLBI can be initially implemented by providing phased-array outputs for SKA1-MID and SKA1-SUR and using these extremely sensitive stations with other radio telescopes, and in SKA2 by realising a distributed configuration providing baselines up to thousands of km, merging it with existing VLBI networks. The motivation for and the possible realization of SKA-VLBI is described in this paper., Comment: 19 pages SKA-VLBI review paper with 5 figures, to be published in the proceedings of "Advancing Astrophysics with the Square Kilometre Array", PoS(AASKA14)143

Published
2014

21. Searching for Extraterrestrial Intelligence with the Square Kilometre Array

Author

Siemion, Andrew P. V., Benford, James, Cheng-Jin, Jin, Chennamangalam, Jayanth, Cordes, James, DeBoer, David R., Falcke, Heino, Garrett, Mike, Garrington, Simon, Gurvits, Leonid, Hoare, Melvin, Korpela, Eric J., Lazio, Joseph, Messerschmitt, David, Morrison, Ian S., O'Brien, Tim, Paragi, Zsolt, Penny, Alan, Spitler, Laura, Tarter, Jill, and Werthimer, Dan

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

The vast collecting area of the Square Kilometre Array (SKA), harnessed by sensitive receivers, flexible digital electronics and increased computational capacity, could permit the most sensitive and exhaustive search for technologically-produced radio emission from advanced extraterrestrial intelligence (SETI) ever performed. For example, SKA1-MID will be capable of detecting a source roughly analogous to terrestrial high-power radars (e.g. air route surveillance or ballistic missile warning radars, EIRP (EIRP = equivalent isotropic radiated power, ~10^17 erg sec^-1) at 10 pc in less than 15 minutes, and with a modest four beam SETI observing system could, in one minute, search every star in the primary beam out to ~100 pc for radio emission comparable to that emitted by the Arecibo Planetary Radar (EIRP ~2 x 10^20 erg sec^-1). The flexibility of the signal detection systems used for SETI searches with the SKA will allow new algorithms to be employed that will provide sensitivity to a much wider variety of signal types than previously searched for. Here we discuss the astrobiological and astrophysical motivations for radio SETI and describe how the technical capabilities of the SKA will explore the radio SETI parameter space. We detail several conceivable SETI experimental programs on all components of SKA1, including commensal, primary-user, targeted and survey programs and project the enhancements to them possible with SKA2. We also discuss target selection criteria for these programs, and in the case of commensal observing, how the varied use cases of other primary observers can be used to full advantage for SETI., Comment: 15 pages, 7 figures, in proceedings of "Advancing Astrophysics with the Square Kilometre Array", PoS(AASKA14)116, in Press

Published
2014

22. Towards Non-spherical Radio Models

Author

Ribeiro, Valério A. R. M., Steffen, Wolfgang, Chomiuk, Laura, Koning, Nico, O'Brien, Tim J., and Woudt, Patrick A.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Radio observations of novae in outburst are of particular interest due to the physical parameters that may be retrieved from fitting the radio light curves. Most models that have fitted previous data assumed spherical symmetry however, it is becoming more and more clear that this is not the case. We explore morpho-kinematical techniques to retrieve the free-free radio light curves of non-spherical models and explore the effects of a non-spherical outburst on the physical parameters. In particular, we find that we may have been over estimating the ejected masses in the outburst of non-spherical novae., Comment: 4 pages, 2 figures, to appear in Stella Novae: Past and Future Decades, P. A. Woudt & V. A. R. M. Ribeiro (eds), ASPCS 490

Published
2014

23. “TREXIT 2020”: why the time to abandon transrectal prostate biopsy starts now

Author

Grummet, Jeremy, Gorin, Michael A., Popert, Rick, O’Brien, Tim, Lamb, Alastair D., Hadaschik, Boris, Radtke, Jan Philipp, Wagenlehner, Florian, Baco, Eduard, Moore, Caroline M., Emberton, Mark, George, Arvin K., Davis, John W., Szabo, Richard J., Buckley, Roger, Loblaw, Andrew, Allaway, Matthew, Kastner, Christof, Briers, Erik, Royce, Peter L., Frydenberg, Mark, Murphy, Declan G., and Woo, Henry H.

Published
2020
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24. Worker Generated Issues, Critical Dialogue, and Praxis: A Freirean Approach to Developing Social Change Projects

Author

O'Brien, Tim

Abstract

The escalating crisis in capitalist relations around the world demands a variety of responses that unmask the confusing structures that perpetuate asymmetrical power relations, while reframing what is truly in the interests of the majority of people. Industrial unions in the U.S. have at times aspired to such an advocacy role, but currently offer little resistance to the loss of living wage jobs. At the grass roots level, there have been promising projects of resistance to globalization growing out of the fields of Popular Education, Participant Research and Critical Pedagogy. Taking a community centered approach these projects attempt to amplify the voices of those most affected by the failing economy, by implementing strategies based on egalitarian and democratic principles stimulating an organically developed critical theory. This dissertation study is an exploration into developing social change projects based on the work of Paulo Freire and informed by other voices within the field of Critical Pedagogy and related traditions. Working with 16 volunteer autoworkers from an assembly plant located in the Midwest of the U.S., this research examines their issues, themes and group process leading to visions of small scale social change. Two themes, "The loss of the middle class", and 'Raising Children: from a community perspective", emerged from one-on-one interviews, and became the generative beginnings for the group work. The group production was considered a success by the participants, developed out of consensus and culminating in envisioned projects potent with possibility for actual implementation. However, analysis of the process and content of the group work revealed several important weaknesses with the way in which the group work was facilitated, particularly in the lack of well developed dialectic reasoning and problem posing in dialogue. The results suggest a lack of politicization engendering a weak form of praxis, allowing the participants to move from their own concrete realities to an abstract position of helping "Others". Several ideas for inserting political elements are suggested in the conclusion of this dissertation. Three appendixes are included: (1) Materials Contained in the Recruitment Packet; (2) Pre-interview Questionnaire; and (3) Interpretive Description of Group Work. (Contains 7 tables and 13 figures.)

Published
2009

25. Spatio-kinematic modelling of Abell 65, a double-shelled planetary nebula with a binary central star

Author

Huckvale, Leo, Prouse, Barnabas, Jones, David, Lloyd, Myfanwy, Pollacco, Don, López, José Alberto, O'Brien, Tim J., Sabin, Laurence, and Vaytet, Neil

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

We present the first detailed spatio-kinematical analysis and modelling of the planetary nebula Abell 65, which is known to host a post-common envelope, binary, central star system. As such, this object is of great interest in studying the link between nebular morphology and central star binarity. [OIII]5007A and H-alpha+[NII]6584A longslit spectra and imagery of Abell 65 were obtained with the Manchester Echelle Spectrometer on the 2.1-m telescope at the San Pedro Martir Observatory (MES-SPM). Further [OIII]5007A longslit spectra were obtained with the Ultraviolet and Visual Echelle Spectrograph on the Very Large Telescope (VLT-UVES). These data were used to develop a spatio-kinematical model for the [OIII]5007A emission from Abell 65. A "best-fit" model was found by comparing synthetic spectra and images rendered from the model to the data. The model comprises an outer shell and an inner shell, with kinematical ages of 15000 +/- 5000 yr kpc^-1 and 8000 +/- 3000 yr kpc^-1, respectively. Both shells have peanut-shaped bipolar structures with symmetry axes at inclinations of 55 +/- 10 deg (to the line-of-sight) for the outer shell and 68 +/- 10 deg for the inner shell. The near-alignment between the nebular shells and the binary orbital inclination (of 68 +/- 2 deg) is strongly indicative that the binary is responsible for shaping the nebula. Abell 65 is one of a growing number of planetary nebulae (seven to date, including Abell 65 itself) for which observations and modelling support the shaping influence of a central binary., Comment: 9 pages, 5 figures, accepted for publication in MNRAS

Published
2013
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26. Radio studies of novae: a current status report and highlights of new results

Author

Roy, Nirupam, Chomiuk, Laura, Sokoloski, Jennifer L., Weston, Jennifer, Rupen, Michael P., Johnson, Traci, Krauss, Miriam I., Nelson, Thomas, Mukai, Koji, Mioduszewski, Amy, Bode, Michael F., Eyres, Stewart P. S., and O'Brien, Tim J.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Novae, which are the sudden visual brightening triggered by runaway thermonuclear burning on the surface of an accreting white dwarf, are fairly common and bright events. Despite their astronomical significance as nearby laboratories for the study of nuclear burning and accretion phenomena, many aspects of these common stellar explosions are observationally not well-constrained and remain poorly understood. Radio observations, modeling and interpretation can potentially play a crucial role in addressing some of these puzzling issues. In this review on radio studies of novae, we focus on the possibility of testing and improving the nova models with radio observations, and present a current status report on the progress in both the observational front and theoretical developments. We specifically address the issues of accurate estimation of ejecta mass, multi-phase and complex ejection phenomena, and the effect of a dense environment around novae. With highlights of new observational results, we illustrate how radio observations can shed light on some of these long-standing puzzles., Comment: 19 pages, 4 figures. Review article published in the Bulletin of the Astronomical Society of India (BASI) special issue on novae

Published
2013

27. Pangolins in global camera trap data: Implications for ecological monitoring

Author

Khwaja, Hannah, Buchan, Claire, Wearn, Oliver R., Bahaa-el-din, Laila, Bantlin, Drew, Bernard, Henry, Bitariho, Robert, Bohm, Torsten, Borah, Jimmy, Brodie, Jedediah, Chutipong, Wanlop, Preez, Byron du, Ebang-Mbele, Alex, Edwards, Sarah, Fairet, Emilie, Frechette, Jackson L., Garside, Adrian, Gibson, Luke, Giordano, Anthony, Veeraswami Gopi, Govindan, Granados, Alys, Gubbi, Sanjay, Harich, Franziska, Haurez, Barbara, Havmøller, Rasmus W., Helmy, Olga, Isbell, Lynne A., Jenks, Kate, Kalle, Riddhika, Kamjing, Anucha, Khamcha, Daphawan, Kiebou-Opepa, Cisquet, Kinnaird, Margaret, Kruger, Caroline, Laudisoit, Anne, Lynam, Antony, Macdonald, Suzanne E., Mathai, John, Sienne, Julia Metsio, Meier, Amelia, Mills, David, Mohd-Azlan, Jayasilan, Nakashima, Yoshihiro, Nash, Helen C., Ngoprasert, Dusit, Nguyen, An, O’Brien, Tim, Olson, David, Orbell, Christopher, Poulsen, John, Ramesh, Tharmalingam, Reeder, DeeAnn, Reyna, Rafael, Rich, Lindsey N., Rode-Margono, Johanna, Rovero, Francesco, Sheil, Douglas, Shirley, Matthew H., Stratford, Ken, Sukumal, Niti, Suwanrat, Saranphat, Tantipisanuh, Naruemon, Tilker, Andrew, Van Berkel, Tim, Van der Weyde, Leanne K., Varney, Matthew, Weise, Florian, Wiesel, Ingrid, Wilting, Andreas, Wong, Seth T., Waterman, Carly, and Challender, Daniel W.S.

Published
2019
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28. The Radio Light Curve of the Gamma-Ray Nova in V407 Cyg: Thermal Emission from the Ionized Symbiotic Envelope, Devoured from Within by the Nova Blast

Author

Chomiuk, Laura, Krauss, Miriam I., Rupen, Michael P., Nelson, Thomas, Roy, Nirupam, Sokoloski, Jennifer L., Mukai, Koji, Munari, Ulisse, Mioduszewski, Amy, Weston, Jennifer, O'Brien, Tim J., Eyres, Stewart P. S., and Bode, Michael F.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics
Abstract

We present multi-frequency radio observations of the 2010 nova event in the symbiotic binary V407 Cygni, obtained with the Karl G. Jansky Very Large Array and spanning 1-45 GHz and 17-770 days following discovery. This nova---the first ever detected in gamma rays---shows a radio light curve dominated by the wind of the Mira giant companion, rather than the nova ejecta themselves. The radio luminosity grew as the wind became increasingly ionized by the nova outburst, and faded as the wind was violently heated from within by the nova shock. This study marks the first time that this physical mechanism has been shown to dominate the radio light curve of an astrophysical transient. We do not observe a thermal signature from the nova ejecta or synchrotron emission from the shock, due to the fact that these components were hidden behind the absorbing screen of the Mira wind. We estimate a mass loss rate for the Mira wind of Mdot_w ~ 10^-6 M_sun/yr. We also present the only radio detection of V407 Cyg before the 2010 nova, gleaned from unpublished 1993 archival VLA data, which shows that the radio luminosity of the Mira wind varies by a factor of >~20 even in quiescence. Although V407 Cyg likely hosts a massive accreting white dwarf, making it a candidate progenitor system for a Type Ia supernova, the dense and radially continuous circumbinary material surrounding V407 Cyg is inconsistent with observational constraints on the environments of most Type Ia supernovae., Comment: Resubmitted to ApJ after incorporating referee's comments

Published
2012
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29. Searching for Extraterrestrial Intelligence with the Square Kilometre Array

Author

Siemion, Andrew PV, Benford, James, Cheng-Jin, Jin, Chennamangalam, Jayanth, Cordes, James, DeBoer, David R, Falcke, Heino, Garrett, Mike, Garrington, Simon, Gurvits, Leonid, Hoare, Melvin, Korpela, Eric J, Lazio, Joseph, Messerschmitt, David, Morrison, Ian S, O'Brien, Tim, Paragi, Zsolt, Penny, Alan, Spitler, Laura, Tarter, Jill, and Werthimer, Dan

Subjects
astro-ph.IM, astro-ph.EP
Abstract

The vast collecting area of the Square Kilometre Array (SKA), harnessed bysensitive receivers, flexible digital electronics and increased computationalcapacity, could permit the most sensitive and exhaustive search fortechnologically-produced radio emission from advanced extraterrestrialintelligence (SETI) ever performed. For example, SKA1-MID will be capable ofdetecting a source roughly analogous to terrestrial high-power radars (e.g. airroute surveillance or ballistic missile warning radars, EIRP (EIRP = equivalentisotropic radiated power, ~10^17 erg sec^-1) at 10 pc in less than 15 minutes,and with a modest four beam SETI observing system could, in one minute, searchevery star in the primary beam out to ~100 pc for radio emission comparable tothat emitted by the Arecibo Planetary Radar (EIRP ~2 x 10^20 erg sec^-1). Theflexibility of the signal detection systems used for SETI searches with the SKAwill allow new algorithms to be employed that will provide sensitivity to amuch wider variety of signal types than previously searched for. Here we discuss the astrobiological and astrophysical motivations for radioSETI and describe how the technical capabilities of the SKA will explore theradio SETI parameter space. We detail several conceivable SETI experimentalprograms on all components of SKA1, including commensal, primary-user, targetedand survey programs and project the enhancements to them possible with SKA2. Wealso discuss target selection criteria for these programs, and in the case ofcommensal observing, how the varied use cases of other primary observers can beused to full advantage for SETI.

Published
2014

31. Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

Author

Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Chambers, Tim, Lopez, Jose I., Nicol, David, O’Brien, Tim, Larkin, James, Horswell, Stuart, Stares, Mark, Au, Lewis, Jamal-Hanjani, Mariam, Challacombe, Ben, Chandra, Ashish, Hazell, Steve, Eichler-Jonsson, Claudia, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Fernando, Archana, Stamp, Gordon, Nye, Emma, Jabbar, Faiz, Spain, Lavinia, Lall, Sharanpreet, Guarch, Rosa, Falzon, Mary, Proctor, Ian, Pickering, Lisa, Gore, Martin, Watkins, Thomas B.K., Ward, Sophia, Stewart, Aengus, DiNatale, Renzo, Becerra, Maria F., Reznik, Ed, Hsieh, James J., Richmond, Todd A., Mayhew, George F., Hill, Samantha M., McNally, Catherine D., Jones, Carol, Rosenbaum, Heidi, Stanislaw, Stacey, Burgess, Daniel L., Alexander, Nelson R., and Swanton, Charles

Published
2018
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32. Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

Author

Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Horswell, Stuart, Chambers, Tim, O’Brien, Tim, Lopez, Jose I., Watkins, Thomas B.K., Nicol, David, Stares, Mark, Challacombe, Ben, Hazell, Steve, Chandra, Ashish, Mitchell, Thomas J., Au, Lewis, Eichler-Jonsson, Claudia, Jabbar, Faiz, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Fernando, Archana, Stamp, Gordon, Nye, Emma, Stewart, Aengus, Xing, Wei, Smith, Jonathan C., Escudero, Mickael, Huffman, Adam, Matthews, Nik, Elgar, Greg, Phillimore, Ben, Costa, Marta, Begum, Sharmin, Ward, Sophia, Salm, Max, Boeing, Stefan, Fisher, Rosalie, Spain, Lavinia, Navas, Carolina, Grönroos, Eva, Hobor, Sebastijan, Sharma, Sarkhara, Aurangzeb, Ismaeel, Lall, Sharanpreet, Polson, Alexander, Varia, Mary, Horsfield, Catherine, Fotiadis, Nicos, Pickering, Lisa, Schwarz, Roland F., Silva, Bruno, Herrero, Javier, Luscombe, Nick M., Jamal-Hanjani, Mariam, Rosenthal, Rachel, Birkbak, Nicolai J., Wilson, Gareth A., Pipek, Orsolya, Ribli, Dezso, Krzystanek, Marcin, Csabai, Istvan, Szallasi, Zoltan, Gore, Martin, McGranahan, Nicholas, Van Loo, Peter, Campbell, Peter, Larkin, James, and Swanton, Charles

Published
2018
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33. Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal

Author

Mitchell, Thomas J., Turajlic, Samra, Rowan, Andrew, Nicol, David, Farmery, James H.R., O’Brien, Tim, Martincorena, Inigo, Tarpey, Patrick, Angelopoulos, Nicos, Yates, Lucy R., Butler, Adam P., Raine, Keiran, Stewart, Grant D., Challacombe, Ben, Fernando, Archana, Lopez, Jose I., Hazell, Steve, Chandra, Ashish, Chowdhury, Simon, Rudman, Sarah, Soultati, Aspasia, Stamp, Gordon, Fotiadis, Nicos, Pickering, Lisa, Au, Lewis, Spain, Lavinia, Lynch, Joanna, Stares, Mark, Teague, Jon, Maura, Francesco, Wedge, David C., Horswell, Stuart, Chambers, Tim, Litchfield, Kevin, Xu, Hang, Stewart, Aengus, Elaidi, Reza, Oudard, Stéphane, McGranahan, Nicholas, Csabai, Istvan, Gore, Martin, Futreal, P. Andrew, Larkin, James, Lynch, Andy G., Szallasi, Zoltan, Swanton, Charles, and Campbell, Peter J.

Published
2018
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34. Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

Author

Harrington, Kevin, Melcher, Alan, Wotherspoon, Andrew, Francis, Nicholas, Challacombe, Ben, Fernando, Archana, Hazell, Steve, Chandra, Ashish, Pickering, Lisa, Lynch, Joanna, Rudman, Sarah, Chowdhury, Simon, Harrison-Phipps, Karen, Varia, Mary, Horsfield, Catherine, Polson, Alexander, Stamp, Gordon, O'Donnell, Marie, Drake, William, Hill, Peter, Hrouda, David, Mayer, Eric, Olsburgh, Jonathan, Kooiman, Gordon, O'Connor, Kevin, Stewart, Grant, Aitchison, Michael, Tran, Maxine, Fotiadis, Nicos, Verma, Hema, Lopez, Jose, Lester, Jason, Morgan, Fiona, Kornaszewska, Malgorzata, Attanoos, Richard, Adams, Haydn, Davies, Helen, Fennell, Dean, Shaw, Jacqui, Le Quesne, John, Nakas, Apostolos, Rathinam, Sridhar, Monteiro, William, Marshall, Hilary, Nelson, Louise, Bennett, Jonathan, Riley, Joan, Primrose, Lindsay, Martinson, Luke, Anand, Girija, Khan, Sajid, Nicolson, Marianne, Kerr, Keith, Palmer, Shirley, Remmen, Hardy, Miller, Joy, Buchan, Keith, Chetty, Mahendran, Gomersall, Lesley, Lock, Sara, Naidu, Babu, Langman, Gerald, Trotter, Simon, Bellamy, Mary, Bancroft, Hollie, Kerr, Amy, Kadiri, Salma, Webb, Joanne, Middleton, Gary, Djearaman, Madava, Summers, Yvonne, Califano, Raffaele, Taylor, Paul, Shah, Rajesh, Krysiak, Piotr, Rammohan, Kendadai, Fontaine, Eustace, Booton, Richard, Evison, Matthew, Crosbie, Phil, Moss, Stuart, Idries, Faiza, Novasio, Juliette, Joseph, Leena, Bishop, Paul, Chaturvedi, Anshuman, Marie Quinn, Anne, Doran, Helen, leek, Angela, Harrison, Phil, Moore, Katrina, Waddington, Rachael, Blackhall, Fiona, Rogan, Jane, Smith, Elaine, Dive, Caroline, Brady, Ged, Rothwell, Dominic, Gulati, Sakshi, Chemie, Francesca, Tugwood, Jonathan, Pierce, Jackie, Lawrence, David, Hayward, Martin, Panagiotopoulos, Nikolaos, George, Robert, Patrini, Davide, Falzon, Mary, Borg, Elaine, Khiroya, Reena, Jamal-Hanjani, Mariam, Wilson, Gareth, Juul Birkbak, Nicolai, Watkins, Thomas, McGranahan, Nicholas, Abbosh, Christopher, Horswell, Stuart, Mitter, Richard, Escudero, Mickael, Stewart, Aengus, Rowan, Andrew, Hiley, Crispin, Goldman, Jacki, Ahmed, Asia, Taylor, Magali, Choudhary, Junaid, Shaw, Penny, Veeriah, Raju, Czyzewska-Khan, Justyna, Johnson, Diana, Laycock, Joanne, Hynds, Robert, Werner Sunderland, Mariana, Reading, James, Novelli, Marco, Oukrif, Dahmane, Janes, Sam, Forster, Martin, Ahmad, Tanya, Ming Lee, Siow, van Loo, Peter, Herrero, Javier, Hartley, John, Kevin Stone, Richard, Denner, Tamara, Costa, Marta, Begum, Sharmin, Phillimore, Ben, Chambers, Tim, Nye, Emma, Ward, Sophie, Elgar, Greg, Al-Bakir, Maise, Carnell, Dawn, Mendes, Ruheena, George, Jeremy, Navani, Neal, Papadatos-Pastos, Dionysis, Scarci, Marco, Gorman, Pat, Lowe, Helen, Ensell, Leah, Moore, David, MacKenzie, Mairead, Wilcox, Maggie, Bell, Harriet, Hackshaw, Allan, Ngai, Yenting, Smith, Sean, Gower, Nicole, Ottensmeier, Christian, Chee, Serena, Johnson, Benjamin, Alzetani, Aiman, Shaw, Emily, Lim, Eric, De Sousa, Paulo, Tavares Barbosa, Monica, Nicholson, Andrew, Bowman, Alex, Jordan, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Proli, Chiara, Elena Cufari, Maria, Carlo Ronquillo, John, Kwayie, Angela, Bhayani, Harshil, Hamilton, Morag, Bakar, Yusura, Mensah, Natalie, Ambrose, Lyn, Devaraj, Anand, Buderi, Silviu, Finch, Jonathan, Azcarate, Leire, Chavan, Hema, Green, Sophie, Mashinga, Hillaria, Lau, Kelvin, Sheaff, Michael, Schmid, Peter, Conibear, John, Ezhil, Veni, Prakash, Vineet, Danson, Sarah, Bury, Jonathan, Edwards, John, Hill, Jennifer, Matthews, Sue, Kitsanta, Yota, Suvarna, Kim, Shackcloth, Michael, Gosney, John, Postmus, Pieter, Feeney, Sarah, Asante-Siaw, Julius, Russell, Peter, Light, Teresa, Horey, Tracey, Blyth, Kevin, Dick, Craig, Kirk, Alan, Arce Vargas, Frederick, Furness, Andrew J.S., Litchfield, Kevin, Joshi, Kroopa, Rosenthal, Rachel, Ghorani, Ehsan, Solomon, Isabelle, Lesko, Marta H., Ruef, Nora, Roddie, Claire, Henry, Jake Y., Spain, Lavinia, Ben Aissa, Assma, Georgiou, Andrew, Wong, Yien Ning Sophia, Smith, Myles, Strauss, Dirk, Hayes, Andrew, Nicol, David, O'Brien, Tim, Mårtensson, Linda, Ljungars, Anne, Teige, Ingrid, Frendéus, Björn, Pule, Martin, Marafioti, Teresa, Gore, Martin, Larkin, James, Turajlic, Samra, Swanton, Charles, Peggs, Karl S., and Quezada, Sergio A.

Published
2018
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36. Orientation effects on bent extragalactic jets

Author

Higgins, Stephen, O'Brien, Tim, and Dunlop, James

Subjects
Astrophysics
Abstract

We have investigated how varying several parameters affects the results of a collision between an extragalactic jet and a dense, intergalactic cloud, through a series of hydrodynamic simulations. We have produced synthetic radio images for comparison with observations. These show that a variety of structures may be produced from simple jet-cloud collisions. Moderate Mach numbers and density contrasts are needed to produce observable bends. We investigate the effect of viewing from various angles on the appearance of such sources., Comment: 7 pages, 2 figures; presented at: Godunov Methods: Theory and Applications, St. Anne's College, Oxford, 18-22 October 1999; HTML version at http://members.netscapeonline.co.uk/leahhiggins/g70jp1.html replaced to correct broken URL

Published
2000

37. Factors associated with weight loss and health gains in a structured lifestyle modification programme for adults with severe obesity: a prospective cohort study

Author

Finucane, Francis M., primary, Gibson, Irene, additional, Hughes, Robert, additional, Murphy, Enda, additional, Hynes, Lisa, additional, Harris, Aisling, additional, McGuire, Brian E., additional, Hynes, Mary, additional, Collins, Chris, additional, Cradock, Kevin, additional, Seery, Suzanne, additional, Jones, Jennifer, additional, O’Brien, Tim, additional, and O’Donnell, Martin J., additional

Published
2023
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38. In The Tornado's Path: BRIDGEPORT?S BARNUM MUSEUM.

Author

Maher, Kathleen and O'Brien, Tim

Subjects
TORNADOES, WASTE recycling
Abstract

The article offers information on the aftermath of a tornado that struck Worcester, MA, in June 2011, causing significant damage to the Barnum Museum. Topics include the extent of the damage to the museum's building and collections, the challenges faced in preserving and protecting the artifacts, and the emotional and practical aspects of disaster recovery efforts.

Published
2024

41. Audit, Feedback, and Education to Improve Quality and Outcomes in Transurethral Resection and Single-Instillation Intravesical Chemotherapy for Nonmuscle Invasive Bladder Cancer Treatment: Protocol for a Multicenter International Observational Study With an Embedded Cluster Randomized Trial

Author

Gallagher, Kevin, primary, Bhatt, Nikita, additional, Clement, Keiran, additional, Zimmermann, Eleanor, additional, Khadhouri, Sinan, additional, MacLennan, Steven, additional, Kulkarni, Meghana, additional, Gaba, Fortis, additional, Anbarasan, Thineskrishna, additional, Asif, Aqua, additional, Light, Alexander, additional, Ng, Alexander, additional, Chan, Vinson, additional, Nathan, Arjun, additional, Cooper, David, additional, Aucott, Lorna, additional, Marcq, Gautier, additional, Teoh, Jeremy Yuen-Chun, additional, Hensley, Patrick, additional, Duncan, Eilidh, additional, Goulao, Beatriz, additional, O'Brien, Tim, additional, Nielsen, Matthew, additional, Mariappan, Paramananthan, additional, and Kasivisvanathan, Veeru, additional

Published
2023
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43. Radiotherapy for Prostate Cancer: is it ‘what you do’ or ‘the way that you do it’? A UK Perspective on Technique and Quality Assurance

Author

Bonnington, Sue, Bradshaw, Lynne, Cooper, Debbie, Elliott, Emma, Herbert, Pippa, Holding, Peter, Howson, Joanne, Jones, Mandy, Lennon, Teresa, Lyons, Norma, Moody, Hilary, Plumb, Claire, O'Sullivan, Tricia, Salter, Liz, Tidball, Sarah, Thompson, Pauline, Adam, Tonia, Askew, Sarah, Atkinson, Sharon, Baynes, Tim, Blaikie, Jan, Brain, Carole, Breen, Viv, Brunt, Sarah, Bryne, Sean, Bythem, Jo, Clarke, Jenny, Cloete, Jenny, Dark, Susan, Davis, Gill, De La Rue, Rachael, Denizot, Jane, Dewhurst, Elspeth, Dimes, Anna, Dixon, Nicola, Ebbs, Penny, Emmerson, Ingrid, Ferguson, Jill, Gadd, Ali, Geoghegan, Lisa, Grant, Alison, Grant, Collette, Gray, Catherine, Godfrey, Rosemary, Goodwin, Louise, Hall, Susie, Hart, Liz, Harvey, Andrew, Hoult, Chloe, Hawkins, Sarah, Holling, Sharon, Innes, Alastair, Kilner, Sue, Marshall, Fiona, Mellen, Louise, Moore, Andrea, Napier, Sally, Needham, Julie, Pearse, Kevin, Pisa, Anna, Rees, Mark, Richards, Elliw, Robson, Lindsay, Roxburgh, Janet, Samuel, Nikki, Sharkey, Irene, Slater, Michael, Smith, Donna, Taggart, Pippa, Taylor, Helen, Taylor, Vicky, Thomas, Ayesha, Tomkies, Briony, Trewick, Nicola, Ward, Claire, Walker, Christy, Williams, Ayesha, Woodhouse, Colin, Wyber, Elizabeth, Aning, Jonathan, Bollina, Prasad, Catto, Jim, Doble, Andrew, Doherty, Alan, Durkan, Garett, Gillatt, David, Hughes, Owen, Kocklebergh, Roger, Kouparis, Anthony, Kynaston, Howard, Leung, Hing, Mariappan, Param, McNeill, Alan, Paez, Edgar, Paul, Alan, Persad, Raj, Powell, Philip, Prescott, Stephen, Rosario, Derek, Rowe, Edward, Schwaibold, Hartwig, Tulloch, David, Wallace, Mike, Bahl, Amit, Benson, Richard, Beresford, Mark, Ferguson, Catherine, Graham, John, Herbert, Chris, Howard, Graham, James, Nick, Law, Alastair, Loughrey, Carmel, Mason, Malcolm, McClaren, Duncan, Patterson, Helen, Pedley, Ian, Robinson, Angus, Russell, Simon, Staffurth, John, Symonds, Paul, Thanvi, Narottam, Vasanthan, Subramaniam, Wilson, Paula, Appleby, Helen, Ash, Dominic, Aston, Dean, Bolton, Steven, Chalmers, Graham, Conway, John, Early, Nick, Geater, Tony, Goddall, Lynda, Heymann, Claire, Hicks, Deborah, Jones, Liza, Lamb, Susan, Lambert, Geoff, Lawrence, Gill, Lewis, Geraint, Lilley, John, MacLeod, Aileen, Massey, Pauline, McQueen, Alison, Moore, Rollo, Penketh, Lynda, Potterton, Janet, Roberts, Neil, Showler, Helen, Slade, Stephen, Steele, Alasdair, Swinscoe, James, Tiffany, Marie, Townley, John, Treeby, Jo, Wilkinson, Joyce, Williams, Lorraine, Wills, Lucy, Woodley, Owain, Yarrow, Sue, Bhattarai, Selina, Deshmukh, Neeta, Dormer, John, Fernando, Malee, Goepel, John, Griffiths, David, Grigor, Ken, Mayer, Nick, Oxley, Jon, Robinson, Mary, Varma, Murali, Warren, Anne, Brindle, Lucy, Davis, Michael, Dedman, Dan, Down, Elizabeth, Khazragui, Hanan, Metcalfe, Chris, Noble, Sian, Peters, Tim, Taylor, Hilary, Turner, Emma, Wade, Julia, Walsh, Eleanor, Baker, Susan, Bellis-Sheldon, Elizabeth, Bougard, Chantal, Bowtell, Joanne, Brewer, Catherine, Burton, Chris, Charlton, Jennie, Christoforou, Nicholas, Clark, Rebecca, Coull, Susan, Croker, Christine, Currer, Rosemary, Daisey, Claire, Delaney, Gill, Donohue, Rose, Drew, Jane, Farmer, Rebecca, Fry, Susan, Haddow, Jean, Hale, Alex, Halpin, Susan, Harris, Belle, Hattrick, Barbara, Holmes, Sharon, Hunt, Helen, Jackson, Vicky, Johnson, Donna, Le Butt, Mandy, Leworthy, Jo, Liddiatt, Tanya, Martin, Alex, Mauree, Jainee, Moore, Susan, Moulam, Gill, Mutch, Jackie, Parker, Kathleen, Pawsey, Christopher, Purdie, Michelle, Robson, Teresa, Smith, Lynne, Stenton, Carole, Steuart-Feilding, Tom, Sully, Chris, Sutton, Caroline, Torrington, Carol, Wilkins, Zoe, Williams, Sharon, Wilson, Andrea, Grant, Adrian, Roberts, Ian, Ashby, Deborah, Cowan, Richard, Fayers, Peter, Mellon, Killian, N'Dow, James, O'Brien, Tim, Sokhal, Michael, Baum, Michael, Adolfson, Jan, Albertsen, Peter, Dearnaley, David, Schroeder, Fritz, Roberts, Tracy, Zietman, Anthony, Mason, M.D., Moore, R., Jones, G., Lewis, G., Donovan, J.L., Neal, D.E., Hamdy, F.C., Lane, J.A., and Staffurth, J.N.

Published
2016
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49. Roundtable Discussion of Appalachian Music—Discussing the Top Ten

Author

Andrade, Roy, Burton, Thomas, Conway, Cece, Doster, Meredith, Duncan, Barbara R., Fleenor, John, Fore, Kevin, Fore, Trish, Freed, Mark, Hay, Fred J., Holt, David, Jones, Loyal, Kahn, Si, Kirby, Rich, Lightfoot, William E., McKenzie, Trevor, O'Brien, Tim, Olson, Ted, Pen, Ron, Pepper, Susan, Poe, Gary, Rorrer, Kinney, Russell, Tony, Spencer, Kilby, Thompson, Deborah, and Wood, Dave

Published
2015

50. Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study

Author

Fu, Xiao, Zhao, Yue, Lopez, Jose I., Rowan, Andrew, Au, Lewis, Fendler, Annika, Hazell, Steve, Xu, Hang, Horswell, Stuart, Shepherd, Scott T. C., Spencer, Charlotte E., Spain, Lavinia, Byrne, Fiona, Stamp, Gordon, O’Brien, Tim, Nicol, David, Augustine, Marcellus, Chandra, Ashish, Rudman, Sarah, Toncheva, Antonia, Furness, Andrew J. S., Pickering, Lisa, Kumar, Santosh, Koh, Dow-Mu, Messiou, Christina, Dafydd, Derfel ap, Orton, Matthew R., Doran, Simon J., Larkin, James, Swanton, Charles, Sahai, Erik, Litchfield, Kevin, Turajlic, Samra, Ben Challacombe, Chowdhury, Simon, Drake, William, Fernando, Archana, Fotiadis, Nicos, Hatipoglu, Emine, Harrison-Phipps, Karen, Hill, Peter, Horsfield, Catherine, Marafioti, Teresa, Olsburgh, Jonathon, Polson, Alexander, Quezada, Sergio, Varia, Mary, Verma, Hema, and Bates, Paul A.

Subjects
0303 health sciences, Ecology, Models, Biological, Article, Computational biology and bioinformatics, Clonal Evolution, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Neoplasms, Cancer genomics, Molecular evolution, Humans, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology
Abstract

Genetic intra-tumour heterogeneity fuels clonal evolution, but our understanding of clinically relevant clonal dynamics remain limited. We investigated spatial and temporal features of clonal diversification in clear cell renal cell carcinoma through a combination of modelling and real tumour analysis. We observe that the mode of tumour growth, surface or volume, impacts the extent of subclonal diversification, enabling interpretation of clonal diversity in patient tumours. Specific patterns of proliferation and necrosis explain clonal expansion and emergence of parallel evolution and microdiversity in tumours. In silico time-course studies reveal the appearance of budding structures before detectable subclonal diversification. Intriguingly, we observe radiological evidence of budding structures in early-stage clear cell renal cell carcinoma, indicating that future clonal evolution may be predictable from imaging. Our findings offer a window into the temporal and spatial features of clinically relevant clonal evolution., A combined modelling and tumour analysis approach is used to study the temporal and spatial patterns of subclone evolution in the TRACERx renal study. Studying the tumour shape and spatial features of clonal diversity in early-stage tumours may allow the prediction of tumour progression and patterns of subclone diversification over time.

Published
2021

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