23 results on '"O'Brien, Karel"'
Search Results
2. Family integrated care: State of art and future perspectives.
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Moreno‐Sanz, Bárbara, Alferink, Milène Tirza, O'Brien, Karel, and Franck, Linda S.
- Abstract
Family integrated care (FICare) represents a contemporary approach to health care that involves the active participation of families within the healthcare team. It empowers families to acquire knowledge about the specialised care required for their newborns admitted to neonatal intensive care unit (NICU) and positions them as primary caregivers. Healthcare professionals in this model act as mentors and facilitators during the hospitalisation period. This innovative model has exhibited notable enhancements in both short‐ and long‐term health outcomes for neonates, alongside improved psychological well‐being for families and heightened satisfaction among healthcare professionals. Initially designed for stable premature infants and their families, FICare has evolved to include critically ill premature and full‐term infants. Findings from recent studies affirm the safety and feasibility of FICare as a NICU‐wide model of care, benefiting all infants and families. The envisioned expansion of FICare focusses on sustainability and extending its implementation, recognising the necessity for tailored adaptations to suit varying diverse cultural and socio‐economic contexts. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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3. A pilot cohort analytic study of Family Integrated Care in a Canadian neonatal intensive care unit.
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O'Brien, Karel, Bracht, Marianne, Macdonell, Kristy, McBride, Tammy, Robson, Kate, O'Leary, Lori, Christie, Kristen, Galarza, Mary, Dicky, Tenzin, Levin, Adik, and Lee, Shoo K.
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COHORT analysis , *NEONATAL intensive care , *INFANT care , *BREASTFEEDING , *WEIGHT in infancy , *RANDOMIZED controlled trials - Abstract
Background: We have developed a Family Integrated Care (FIC) model for use in a neonatal intensive care unit (NICU) where parents provide most of the care for their infant, while nurses teach and counsel parents. The objective of this pilot prospective cohort analytic study was to explore the feasibility, safety, and potential outcomes of implementing this model in a Canadian NICU. Methods: Infants born ⩽35 weeks gestation, receiving continuous positive airway pressure or less respiratory support, with a primary caregiver willing and able to spend ⩾8 hours a day with their infant were eligible. Families attended daily education sessions and were mentored at the bedside by nurses. The primary outcome was weight gain, as measured by change in z-score for weight 21 days after enrolment. For each enrolled infant, we identified two matched controls from the previous year's clinical database. Differences in weight gain between the two groups were analyzed using a linear mixed effects multivariable regression model. We also measured parental stress levels using the Parental Stress Survey: NICU, and interviewed parents and nurses regarding their experiences with FIC. Results: This study included 42 mothers and their infants. Of the enrolled infants, matched control data were available for 31 who completed the study. The rate of change in weight gain was significantly higher in FIC infants compared with control infants (p < 0.05). There was also a significant increase in the incidence of breastfeeding at discharge (82.1 vs. 45.5%, p < 0.05). The mean Parental Stress Survey: NICU score for FIC mothers was 3.06 ± 0.12 at enrolment, which decreased significantly to 2.30 ± 0.13 at discharge (p < 0.05). Feedback from the parents and nurses indicated that FIC was feasible and appropriately implemented. Conclusions: This study suggests that the FIC model is feasible and safe in a Canadian healthcare setting and results in improved weight gain among preterm infants. In addition, this innovation has the potential to improve other short and long-term infant and family outcomes. A multi-centre randomized controlled trial is needed to further evaluate the efficacy of FIC in the Canadian context. [ABSTRACT FROM AUTHOR]
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- 2013
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4. Parents as primary caregivers in the neonatal intensive care unit.
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Shoo K. Lee and O'Brien, Karel
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NEONATAL intensive care , *INFANT health services , *HOSPITAL care of newborn infants , *CAREGIVERS , *MEDICAL decision making , *DECISION making in child welfare - Abstract
The article discusses a study of the Family Integrated Care program in neonatal intensive care units in Canada. Topics discussed include the program designed to promote skin-to-skin care, involve parents in caregiving and decision-making and provide education and psychological support, integration of parents into the care of their infants starting at admission and psychosocial and physical support including support from other families.
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- 2014
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5. Invasive candidiasis in low birth weight preterm infants: risk factors, clinical course and outcome in a prospective multicenter study of cases and their matched controls.
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Barton, Michelle, O'Brien, Karel, Robinson, Joan L, Davies, Dele H, Simpson, Kim, Asztalos, Elizabeth, Langley, Joanne M, Le Saux, Nicole, Sauve, Reg, Synnes, Anne, Tan, Ben, de Repentigny, Louis, Rubin, Earl, Hui, Chuck, Kovacs, Lajos, and Richardson, Susan E
- Abstract
Background: This multicenter prospective study of invasive candidiasis (IC) was carried out to determine the risk factors for, incidence of, clinical and laboratory features, treatment and outcome of IC in infants of birth weight <1250 g.Methods: Neonates <1250 g with IC and their matched controls (2:1) were followed longitudinally and descriptive analysis was performed. Survivors underwent neurodevelopmental assessment at 18 to 24 months corrected age. Neurodevelopmental impairment (NDI) was defined as blindness, deafness, moderate to severe cerebral palsy, or a score <70 on the Bayley Scales of Infant Development 2nd edition. Multivariable analyses were performed to determine risk factors for IC and predictors of mortality and NDI.Results: Cumulative incidence rates of IC were 4.2%, 2.2% and 1.5% for birth-weight categories <750 g, <1000 g, <1500 g, respectively. Forty nine infants with IC and 90 controls were enrolled. Necrotizing enterocolitis (NEC) was the only independent risk factor for IC (p=0.03). CNS candidiasis occurred in 50% of evaluated infants, while congenital candidiasis occurred in 31%. Infants with CNS candidiasis had a higher mortality rate (57%) and incidence of deafness (50%) than the overall cohort of infants with IC. NDI (56% vs. 33%; p=0.017) and death (45% vs. 7%; p=0.0001) were more likely in cases than in controls, respectively. IC survivors were more likely to be deaf (28% vs. 7%; p=0.01). IC independently predicted mortality (p=0.0004) and NDI (p=0.018).Conclusion: IC occurred in 1.5% of VLBW infants. Preceding NEC increased the risk of developing IC. CNS candidiasis is under-investigated and difficult to diagnose, but portends a very poor outcome. Mortality, deafness and NDI were independently significantly increased in infants with IC compared to matched controls. [ABSTRACT FROM AUTHOR]- Published
- 2014
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6. A pilot cohort analytic study of Family Integrated Care in a Canadian neonatal intensive care unit.
- Author
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O'Brien, Karel, Bracht, Marianne, Macdonell, Kristy, McBride, Tammy, Robson, Kate, O'Leary, Lori, Christie, Kristen, Galarza, Mary, Dicky, Tenzin, Levin, Adik, and Lee, Shoo K
- Abstract
Background: We have developed a Family Integrated Care (FIC) model for use in a neonatal intensive care unit (NICU) where parents provide most of the care for their infant, while nurses teach and counsel parents. The objective of this pilot prospective cohort analytic study was to explore the feasibility, safety, and potential outcomes of implementing this model in a Canadian NICU.Methods: Infants born ≤ 35 weeks gestation, receiving continuous positive airway pressure or less respiratory support, with a primary caregiver willing and able to spend ≥ 8 hours a day with their infant were eligible. Families attended daily education sessions and were mentored at the bedside by nurses. The primary outcome was weight gain, as measured by change in z-score for weight 21 days after enrolment. For each enrolled infant, we identified two matched controls from the previous year's clinical database. Differences in weight gain between the two groups were analyzed using a linear mixed effects multivariable regression model. We also measured parental stress levels using the Parental Stress Survey: NICU, and interviewed parents and nurses regarding their experiences with FIC.Results: This study included 42 mothers and their infants. Of the enrolled infants, matched control data were available for 31 who completed the study. The rate of change in weight gain was significantly higher in FIC infants compared with control infants (p < 0.05). There was also a significant increase in the incidence of breastfeeding at discharge (82.1 vs. 45.5%, p < 0.05). The mean Parental Stress Survey: NICU score for FIC mothers was 3.06 ± 0.12 at enrolment, which decreased significantly to 2.30 ± 0.13 at discharge (p < 0.05). Feedback from the parents and nurses indicated that FIC was feasible and appropriately implemented.Conclusions: This study suggests that the FIC model is feasible and safe in a Canadian healthcare setting and results in improved weight gain among preterm infants. In addition, this innovation has the potential to improve other short and long-term infant and family outcomes. A multi-centre randomized controlled trial is needed to further evaluate the efficacy of FIC in the Canadian context. [ABSTRACT FROM AUTHOR]- Published
- 2013
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- View/download PDF
7. Early-Onset Invasive Candidiasis in Extremely Low Birth Weight Infants: Perinatal Acquisition Predicts Poor Outcome.
- Author
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Barton, Michelle, Shen, Alex, O'Brien, Karel, Robinson, Joan L., Davies, H.Dele, Simpson, Kim, Asztalos, Elizabeth, Langley, Joanne, Le Saux, Nicole, Sauve, Reginald, Synnes, Anne, Tan, Ben, de Repentigny, Louis, Rubin, Earl, Hui, Chuck, Kovacs, Lajos, Yau, Yvonne C. W., and Richardson, Susan E.
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CANDIDIASIS , *LOW birth weight , *WEIGHT in infancy , *CHORIOAMNIONITIS , *NEURODEVELOPMENTAL treatment for infants , *INFANT mortality - Abstract
Background. Neonatal invasive candidiasis (IC) presenting in the first week of life is less common and less well described than later-onset IC. Risk factors, clinical features, and disease outcomes have not been studied in early-onset disease (EOD, ⩽7 days) or compared to late-onset disease (LOD, >7 days). Methods. All extremely low birth weight (ELBW, <1000 g) cases with IC and controls from a multicenter study of neonatal candidiasis enrolled from 2001 to 2003 were included in this study. Factors associated with occurrence and outcome of EOD in ELBW infants were determined. Results. Forty-five ELBW infants and their 84 matched controls were included. Fourteen (31%) ELBW infants had EOD. Birth weight <750 g, gestation <25 weeks, chorioamnionitis, and vaginal delivery were all strongly associated with EOD. Infection with Candida albicans, disseminated disease, pneumonia, and cardiovascular disease were significantly more common in EOD than in LOD. The EOD case fatality rate (71%) was higher than in LOD (32%) or controls (15%) (P = .0001). The rate of neurodevelopmental impairment and mortality combined was similar in EOD (86%) and LOD (72%), but higher than in controls (32%; P = .007). Conclusions. ELBW infants with EOD have a very poor prognosis compared to those with LOD. The role of perinatal transmission in EOD is supported by its association with chorioamnionitis, vaginal delivery, and pneumonia. Dissemination and cardiovascular involvement are common, and affected infants often die. Empiric treatment should be considered for ELBW infants delivered vaginally who have pneumonia and whose mothers have chorioamnionitis or an intrauterine foreign body. [ABSTRACT FROM AUTHOR]
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- 2017
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8. Supporting parents as essential care partners in neonatal units during the SARS-CoV-2 pandemic.
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Veenendaal, Nicole R., Deierl, Aniko, Bacchini, Fabiana, O'Brien, Karel, Franck, Linda S., van Veenendaal, Nicole R, and International Steering Committee for Family Integrated Care
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COVID-19 pandemic , *NEONATAL nursing , *PARENTS , *MEDICAL personnel , *PARENTING , *SARS-CoV-2 - Abstract
Aim: To review the evidence on safety of maintaining family integrated care practices and the effects of restricting parental participation in neonatal care during the SARS-CoV-2 pandemic.Methods: MEDLINE, EMBASE, PsycINFO and CINAHL databases were searched from inception to the 14th of October 2020. Records were included if they reported scientific, empirical research (qualitative, quantitative or mixed methods) on the effects of restricting or promoting family integrated care practices for parents of hospitalised neonates during the SARS-CoV-2 pandemic. Two authors independently screened abstracts, appraised study quality and extracted study and outcome data.Results: We retrieved 803 publications and assessed 75 full-text articles. Seven studies were included, reporting data on 854 healthcare professionals, 442 parents, 364 neonates and 26 other family members, within 286 neonatal units globally. The pandemic response resulted in significant changes in neonatal unit policies and restricting parents' access and participation in neonatal care. Breastfeeding, parental bonding, participation in caregiving, parental mental health and staff stress were negatively impacted.Conclusion: This review highlights that SARS-CoV-2 pandemic-related hospital restrictions had adverse effects on care delivery and outcomes for neonates, families and staff. Recommendations for restoring essential family integrated care practices are discussed. [ABSTRACT FROM AUTHOR]- Published
- 2021
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9. Evaluating the effect of Family Integrated Care on maternal stress and anxiety in neonatal intensive care units.
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Cheng, Chelsea, Franck, Linda S., Ye, Xiang Y., Hutchinson, Sarah A., Lee, Shoo K., and O'Brien, Karel
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PREVENTION of psychological stress , *NEONATAL intensive care , *ATTITUDES of mothers , *CONFIDENCE intervals , *FAMILY medicine , *NEONATAL intensive care units , *GESTATIONAL age , *TREATMENT effectiveness , *PARENTING , *COMPARATIVE studies , *QUESTIONNAIRES , *DESCRIPTIVE statistics , *INTEGRATED health care delivery , *CLUSTER analysis (Statistics) , *SECONDARY analysis , *EVALUATION ,ANXIETY prevention - Abstract
Objective: To identify how Family Integrated Care (FICare) affected maternal stress and anxiety. Study Design: This secondary analysis of the FICare cluster randomised controlled trial included infants born between 1 April 2013 and 31 August 2015 at ≤33 weeks' gestation. Mothers completed the PSS:NICU and STAI questionnaires at enrolment and study day 21. Results: 1383 mothers completed the surveys at one or both time-points. The mean PSS:NICU and STAI scores at day 21 were significantly lower in the FICare mothers than controls (PSS:NICU mean [standard deviation] FICare 2.32 [0.75], control 2.48 [0.78], p = 0.0005; STAI FICare 70.8 [20.0], control 74.2 [19.6], p = 0.0004). The sights and sounds, looks and behaviour, and parental role PSS:NICU subscales and the state and trait STAI subscales were all significantly different between FIC are and controls at day 21. The magnitude of change in all stress and anxiety subscales was greater in the FICare group than controls. These differences remained significant after adjustment for confounders with the greatest change in the parental role (least-squares mean [95% confidence interval] FICare −0.65 [−0.72, 0.57], control −0.31 [−0.38, −0.24], p < 0.0001) and state anxiety subscales. Conclusion: FICare is effective at reducing NICU-related maternal stress and anxiety. [ABSTRACT FROM AUTHOR]
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- 2021
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10. The Canadian Preterm Birth Network: a study protocol for improving outcomes for preterm infants and their families.
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Shah, Prakesh S., McDonald, Sarah D., Barrett, Jon, Synnes, Anne, Robson, Kate, Foster, Jonathan, Pasquier, Jean-Charles, Joseph, K.S., Piedboeuf, Bruno, Lacaze-Masmonteil, Thierry, O'Brien, Karel, Shivananda, Sandesh, Chaillet, Nils, and Pechlivanoglou, Petros
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PREMATURE labor , *RESEARCH protocols , *PREMATURE infants - Abstract
Background: Preterm birth (birth before 37 wk of gestation) occurs in about 8% of pregnancies in Canada and is associated with high mortality and morbidity rates that substantially affect infants, their families and the health care system. Our overall goal is to create a transdisciplinary platform, the Canadian Preterm Birth Network (CPTBN), where investigators, stakeholders and families will work together to improve childhood outcomes of preterm neonates. Methods: Our national cohort will include 24 maternal--fetal/obstetrical units, 31 neonatal intensive care units and 26 neonatal follow-up programs across Canada with planned linkages to provincial health information systems. Three broad clusters of projects will be undertaken. Cluster 1 will focus on quality-improvement efforts that use the Evidence-based Practice for Improving Quality method to evaluate information from the CPTBN database and review the current literature, then identify potentially better health care practices and implement identified strategies. Cluster 2 will assess the impact of current practices and practice changes in maternal, perinatal and neonatal care on maternal, neonatal and neurodevelopmental outcomes. Cluster 3 will evaluate the effect of preterm birth on babies, their families and the health care system by integrating CPTBN data, parent feedback, and national and provincial database information in order to identify areas where more parental support is needed, and also generate robust estimates of resource use, cost and cost-effectiveness around preterm neonatal care. Interpretation: These collaborative efforts will create a flexible, transdisciplinary, evaluable and informative research and quality-improvement platform that supports programs, projects and partnerships focused on improving outcomes of preterm neonates. [ABSTRACT FROM AUTHOR]
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- 2018
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11. Perceptions of Health Professionals on Pain in Extremely Low Gestational Age Infants.
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Gibbins, Sharyn, Stevens, Bonnie, Dionne, Kim, Yamada, Janet, Pillai Riddell, Rebecca, McGrath, Patrick, Asztalos, Elizabeth, O’Brien, Karel, Beyene, Joseph, McNamara, Patrick, and Johnston, Celeste
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MEDICAL personnel , *ATTITUDE (Psychology) , *LOW birth weight , *CONCEPTUAL structures , *CONTENT analysis , *FOCUS groups , *PREMATURE infants , *INTERVIEWING , *MATHEMATICAL models , *RESEARCH methodology , *NEONATAL intensive care , *NURSES , *OCCUPATIONAL therapists , *PAIN in children , *PHARMACISTS , *PHYSICIANS , *QUESTIONNAIRES , *RESEARCH funding , *RESPIRATORY therapists , *STATISTICAL sampling , *SCALE analysis (Psychology) , *QUALITATIVE research , *THEORY , *QUANTITATIVE research , *EVIDENCE-based nursing , *PAIN measurement , *THEMATIC analysis , *NEONATAL intensive care units - Published
- 2015
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12. Parents as practitioners in preterm care.
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Jiang, Siyuan, Warre, Ruth, Qiu, Xiangming, O'Brien, Karel, and Lee, Shoo K.
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PREMATURE infants , *TRAUMA centers , *INTENSIVE care units , *INFANT physiology ,INFANTS' injuries - Abstract
The very preterm birth of an infant is physiologically traumatic for the infant and physiologically and psychologically traumatic for the parents. The manner of care delivery in the first few days and weeks of the infant's life plays a large role in determining the impact of that trauma. For optimal outcomes parents need to be integrated into the care process as the primary practitioners of their infant's care in the neonatal intensive care unit. Supporting and enabling parents to be central to the care process establishes a consistent care environment where parents are in control and able to support their infant's physiological and psychological needs, thereby improving infant outcomes and reducing parent stress and anxiety. This article reviews the role of parents in the optimal development of preterm neonates, and discusses the elements crucial to promoting parent involvement in the neonatal intensive care unit and supporting parents following discharge. [ABSTRACT FROM AUTHOR]
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- 2014
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13. The Influence of Context on Pain Practices in the NICU: Perceptions of Health Care Professionals.
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Stevens, Bonnie, Riahi, Shirine, Cardoso, Roberta, Ballantyne, Marilyn, Yamada, Janet, Beyene, Joseph, Breau, Lynn, Camfield, Carol, Finley, G. Allen, Franck, Linda, Gibbins, Sharyn, Howlett, Alexandra, McGrath, Patrick J., McKeever, Patricia, O'Brien, Karel, and Ohlsson, Arne
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PAIN management , *ANALYSIS of variance , *ATTITUDE (Psychology) , *CONTENT analysis , *FOCUS groups , *INTERVIEWING , *LONGITUDINAL method , *RESEARCH methodology , *MEDICAL personnel , *NEONATAL intensive care , *SENSORY perception , *RESEARCH , *RESEARCH funding , *DECISION making in clinical medicine , *QUALITATIVE research , *JUDGMENT sampling , *PAIN measurement , *THEMATIC analysis , *NEONATAL intensive care units , *CHILDREN - Published
- 2011
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14. Motivated by Money? The Impact of Financial Incentive for the Research Team on Study Recruitment.
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UNGER, SHARON, WYLIE, LESLEY, FALLAH, SHAFAGH, HEINRICH, LEE, and O'BRIEN, KAREL
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MONETARY incentives , *RESEARCH teams , *HUMAN research subjects , *NEONATAL intensive care & ethics , *PARENTS of sick children , *RESEARCH ethics , *FINANCE - Abstract
The article presents a research study concerning the impact of financial incentives for a research team on study participant recruitment of parents with children in the neonatal intensive care unit (NICU). The authors report that recruitment of NICU research participants is difficult because multiple clinical trials desire the same study population and the NICU experience is a time of stress and anxiety for parents.
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- 2010
15. Changes in physiological and behavioural pain indicators over time in preterm and term infants at risk for neurologic impairment
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Gibbins, Sharyn, Stevens, Bonnie, McGrath, Patrick, Dupuis, Annie, Yamada, Janet, Beyene, Joseph, Breau, Lynn, Camfield, Carol, Finley, G. Allen, Franck, Linda, Johnston, Celeste, McKeever, Patricia, O'Brien, Karel, and Ohlsson, Arne
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NEWBORN infant care , *INFANT health services , *INTENSIVE care units , *CRITICAL care medicine - Abstract
Abstract: Background: Approximately 10% of infants admitted to a Neonatal Intensive Care Unit (NICU) are at risk for Neurological Impairment (NI). While we have limited knowledge on the influence of NI risk on pain responses, we have no knowledge of how these responses change over time. Objective: To compare physiological and behavioural pain responses of infants at three levels of NI risk during the NICU neonatal period (Session 1) and at 6 months of age (Session 2). Design/methods: Prospective observational design with 149 preterm and term infants at high (Cohort A, n =54), moderate (Cohort B, n =45) and mild (Cohort C, n =50) risks for NI from 3 Canadian tertiary level NICUs. Infants were observed in the NICU during 3 standardized phases of a heel lance: baseline, stick and return-to-baseline. At 6 months, infants were observed during the same three phases during an intramuscular immunization injection. Physiological (heart rate, oxygen saturation) and behavioural (9 facial actions, cry) responses were continuously recorded. Results: A significant interaction of Phase by Session was found with less total facial activity observed during Session 2 (all p values<0.04). A significant interaction for Session by Cohort was found, showing that infants in Cohort A had significantly more change from baseline-to-stick phase for brow bulge, eye squeeze, nasolabial furrow and open lips between sessions with less facial actions demonstrated at Session 2 (all p <0.02). There were significantly lower mean and minimum heart rate (all p <0.02) and higher minimum and maximum oxygen saturation (p <0.04) at Session 2. Significantly higher mean and minimum fundamental cry frequencies (pitch) in Cohort B (p <0.04) were found in Session 1. Cohort A had significantly longer cry durations, but no significant differences in cry dysphonation. Conclusions: Behavioural and physiological infant pain responses were generally diminished at 6 months of age compared to those in the neonatal period with some differences between NI risk groups in cry responses. Future exploration into the explanation for these differences between sessions and cohorts is warranted. [Copyright &y& Elsevier]
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- 2008
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16. Determining behavioural and physiological responses to pain in infants at risk for neurological impairment
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Stevens, Bonnie, McGrath, Patrick, Gibbins, Sharyn, Beyene, Joseph, Breau, Lynn, Camfield, Carol, Finley, Allen, Franck, Linda, Howlett, Alexandra, Johnston, Celeste, McKeever, Patricia, O’Brien, Karel, Ohlsson, Arne, and Yamada, Janet
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PAIN in infants , *DISABILITIES , *PAIN measurement , *NEWBORN infants - Abstract
Abstract: Multiple researchers have validated indicators and measures of infant pain. However, infants at risk for neurologic impairment (NI) have been under studied. Therefore, whether their pain responses are similar to those of other infants is unknown. Pain responses to heel lance from 149 neonates (GA>25–40 weeks) from 3 Canadian Neonatal Intensive Care units at high (Cohort A, n =54), moderate (Cohort B, n =45) and low (Cohort C, n =50) risk for NI were compared in a prospective observational cohort study. A significant Cohort by Phase interaction for total facial action (F (6,409) =3.50, p =0.0022) and 4 individual facial actions existed; with Cohort C demonstrating the most facial action. A significant Phase effect existed for increased maximum Heart Rate (F (3,431) =58.1, p =0.001), minimum Heart Rate (F (3,431) =78.7, p =0.001), maximum Oxygen saturation (F (3,425) =47.6, p =0.001), and minimum oxygen saturation (F (3,425) =12.2, p =0.001) with no Cohort differences. Cohort B had significantly higher minimum (F (2,79) =3.71, p =0.029), and mean (F (2,79) =4.04, p =0.021) fundamental cry frequencies. A significant Phase effect for low/high frequency Heart Rate Variability (HRV) ratio (F (2,216) =4.97, p =0.008) was found with the greatest decrease in Cohort A. Significant Cohort by Phase interactions existed for low and high frequency HRV. All infants responded to the most painful phase of the heel lance; however, infants at moderate and highest risk for NI exhibited decreased responses in some indicators. [Copyright &y& Elsevier]
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- 2007
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17. Procedural pain in newborns at risk for neurologic impairment
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Stevens, Bonnie, McGrath, Patrick, Gibbins, Sharyn, Beyene, Joseph, Breau, Lynn, Camfield, Carol, Finley, Allen, Franck, Linda, Howlett, Alixe, McKeever, Patricia, O'Brien, Karel, Ohlsson, Arne, and Yamada, Janet
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NEONATAL diseases , *PAIN , *NEUROLOGY , *SEDATIVES - Abstract
In the past decade, our knowledge of pain in newborn infants has advanced considerably. However, infants at significant risk for neurologic impairment (NI) have been systematically excluded from almost all research on pain in neonates. The objectives of this study were to compare: (a) the nature, frequency and prevalence of painful procedures, (b) analgesics and sedatives administered, and (c) the relationship between painful procedures and analgesia for neonates at risk for NI. One hundred and ninety-four infants at high (cohort A,
n=67 ), moderate (cohort B,n=59 ) and low (cohort C,n=68 ) risk for NI from two tertiary level Neonatal Intensive Care Unit''s in Canada were included in a retrospective cohort study on the first 7 days of life. Data were collected from medical records and analyzed using chi-square, ANOVA and regression approaches. All cohorts had a mean of >10 painful procedures per day during the first 2 days of life. There was an interaction effect between cohort group and day of life (F5,188=2.13 ,P<0.06 ) with cohort A having significantly more painful procedures on day 1 (F2,191=4.79 ,P<0.009 ). There was no statistical difference in the number of infants who received continuous infusion (F2,20=1.9 ,P=0.13 ) or bolus (F2,20=1.3 ,P=0.25 ) opioids or sedatives (F2,20=0.45 ,P=0.84 ) by cohort over the 7 day period. There was a statistical difference in bolus opioid administration for days 1(P<0.05) and 2(P<0.001) with less than 10% of infants in cohort A receiving bolus opioids compared with approximately 22–33% of infants in cohorts B and C. There was a statistically significant correlation between painful procedures and analgesic use (r=0.29 ,P<0.001 ), although significant associations existed for cohorts B and C only. The number of painful procedures and study site primarily accounted for the variance (61% in cohort B and 35% in cohort C) in analgesic use, while in cohort A, only study site contributed to the variance (16%). Neonates at the highest risk for NI had the greatest number of painful procedures and the least amount of opioids administered during the first day of life. There was no relationship between painful procedures and analgesic use in this group. As these infants are vulnerable to pain and its consequences, the rational underlying health professional strategies regarding painful procedures and analgesic use for procedural pain in this population urgently awaits exploration. [Copyright &y& Elsevier]- Published
- 2003
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18. Complications Associated With Surgically Placed Central Venous Catheters In Low Birth Weight Neonates.
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Pandit, Paresh B, Pandit, Florence A, Govan, Jairaj, and O’Brien, Karel
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INTRAVENOUS catheterization , *NEWBORN infants , *LOW birth weight - Abstract
OBJECTIVE: To determine the incidence of complications in low birth weight neonates with surgically inserted central venous catheters (CVCs). STUDY DESIGN: Retrospective chart review of all neonates ≤ 1500-gm birth weight from three tertiary care neonatal intensive care units who required CVC insertion. RESULTS: A total of 112 CVCs was inserted in 104 neonates with birth weight of 798 (490 to 1380) gm, age 16 (3 to 179) days, for a duration of 21 (1 to 130) days. The birth weights of 85 neonates were ≤1000 gm. One or more complications associated with the CVC occurred in 59 patients (57%). Sepsis was the commonest complication, with 43 episodes in 38 patients, at a rate of 14.5 episodes/1000 catheter days. Using regression analysis, sepsis was associated with birth weight, male sex, and the duration for which the CVC remained in place. Five of the nine who developed superior vena cava syndrome and/or pleural effusions died. CONCLUSION: CVCs can provide venous access that is durable. However, in the LBW neonate, and especially in those of ≤1000 gm, there is a high incidence of associated complications. [ABSTRACT FROM AUTHOR]
- Published
- 1999
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19. Alpha1-proteinase inhibitor therapy for the prevention of chronic lung disease of prematurity: A...
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Stiskal, Joseph A., Dunn, Michael S., Shennan, Andrew T., O'Brien, Karel K.E., Kelly, Edmond N., Koppel, Robert I., Cox, Diane W., Ito, Shinya, Chappel, S. Lesley, and Rabinovitch, Marlene
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PROTEINASES , *LUNG disease prevention , *PREMATURE infant diseases , *CHEMOPREVENTION , *CHEMICAL inhibitors , *THERAPEUTICS - Abstract
Reports on a randomized, placebo-controlled trial on the use of alpha-proteinase inhibitor therapy for the prevention of chronic lung disease of prematurity. Randomization; Primary and secondary outcomes; Complications of prematurity; Confounders.
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- 1998
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20. Case 2: Sepsis and shock in a term neonate.
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Coles, Nicole, Wolfe-Wylie, Margaret, Atkinson, Adelle, O'Brien, Karel, and Unger, Sharon
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BRAIN , *RADIOGRAPHY , *CEREBROSPINAL fluid examination , *STREPTOCOCCAL disease diagnosis , *BLOOD testing , *DIFFERENTIAL diagnosis , *HERPES simplex , *POLYMERASE chain reaction , *SEPSIS , *SHOCK (Pathology) , *TOMOGRAPHY , *DECISION making in clinical medicine , *VIRIDANS strepotococci , *DISEASE complications , *CHILDREN - Abstract
The article discusses the case of a seven-day-old boy who died due to Herpes simplex sepsis. The patient presented with a history of fever and irritability, but he has no history of maternal fever, prolonged rupture of membranes or infectious symptoms involving close contacts. Herpes simplex virus 2 (HSV2) is a common pathogen that causes sepsis in the newborn period and it is typically vertically transmitted from an infected mother during delivery by viral shedding.
- Published
- 2013
21. Family Integrated Care (FICare): Positive impact on behavioural outcomes at 18 months.
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Church, Paige Terrien, Grunau, Ruth E., Mirea, Lucia, Petrie, Julie, Soraisham, Amuchou Singh, Synnes, Anne, Ye, Xiang Y., and O'Brien, Karel
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MEDIATION (Statistics) , *CLUSTER randomized controlled trials , *PARENTING Stress Index , *PSYCHOLOGICAL stress , *INFANT growth , *PARENT-infant relationships , *TREATMENT of psychological stress , *PREVENTION of psychological stress , *RESEARCH , *PSYCHOLOGY of parents , *PREMATURE infants , *CHILD development , *RESEARCH methodology , *MEDICAL cooperation , *EVALUATION research , *COMPARATIVE studies , *PSYCHOSOCIAL factors , *RESEARCH funding , *INFANT psychology , *PSYCHOTHERAPY , *EARLY medical intervention - Abstract
Background: Children born very preterm demonstrate behavioural challenges due to clinical factors, exposure to the high stress environment of intensive care, and separation from parents during neonatal hospitalization at a critical stage in development. Family Integrated Care (FICare) significantly reduced parent stress and anxiety, and improved neonatal outcomes.Aims: To examine the impact of FICare on behavioural outcomes at 18-21 months corrected age (CA), and assess possible mediation through parenting or infant growth.Study Design and Methods: A prospective cohort study enrolling infants under 33 weeks gestation and parents from the FICare cluster randomized controlled trial. Primary outcome was behaviour assessed by the Infant Toddler Social Emotional Assessment (ITSEA). Parent child variables were measured with the Nursing Child Assessment Satellite Training (NCAST), Parenting Stress Index (PSI) and infant growth.Results: Subjects included 123 FICare infants and 62 standard care controls evaluated at 18-21 months CA. FICare infants demonstrated lower ITSEA Dysregulation, indicating better self-regulation skills, compared with the control group (T-score 41.7 vs 46.6, p < 0.01). At 12 months CA, the NCAST Child subtotal score was higher and the PSI-Child Domain score was lower in FICare infants than non-FICare infants. The PSI-Child domain was identified as a possible mediator of FICare on child behaviour (mediation effect 1.28, -2.96-0.02, p = 0.044).Conclusion: FICare in the NICU has a sustained effect on child behaviour, improving self-regulation at 18-21 months CA. [ABSTRACT FROM AUTHOR]- Published
- 2020
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22. A multilayered approach is needed in the NICU to support parents after the preterm birth of their infant.
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Treyvaud, Karli, Spittle, Alicia, Anderson, Peter J., and O'Brien, Karel
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PREMATURE infants , *PREMATURE labor , *HOSPITAL admission & discharge , *INTENSIVE care units , *PARENTS , *CHILDBIRTH - Abstract
The premature birth of a child and admission to the neonatal intensive care unit (NICU) is a distressing experience for parents, and has been associated with symptoms of depression, anxiety and post-traumatic stress. Supporting parents in the NICU after preterm birth is critical not only for their own mental health, but also due to potential implications for their relationship with their infant and subsequent child development. This review draws from current published clinical guidelines developed to support parents in the NICU, guidelines on family centered care in intensive care units, and reviews on the effectiveness of interventions for infants and children born preterm. A multilayered approach to supporting parents of infants born preterm in the NICU is recommended, with evidence specifically for including layers of individual psychological and psychosocial support, peer-to-peer support, and family centered care. Consideration of fathers in the NICU, and areas for future research are also discussed. [ABSTRACT FROM AUTHOR]
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- 2019
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23. Characteristics and outcome of infants with candiduria in neonatal intensive care - a Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study.
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Robinson JL, Davies HD, Barton M, O'Brien K, Simpson K, Asztalos E, Synnes A, Rubin E, Le Saux N, Hui C, Langley JM, Sauve R, de Repentigny L, Kovacs L, Tan B, Richardson SE, Robinson, Joan L, Davies, H Dele, Barton, Michelle, and O'Brien, Karel
- Abstract
Background: There is limited information in the literature on the presentation and prognosis of candidal urinary tract infection (UTI) in infants in the neonatal intensive care unit (NICU).Methods: This was a prospective cohort study performed in 13 Canadian NICUs. Infants with candidal UTI without extra-renal candidal infection at presentation were enrolled.Results: Thirty infants fit the study criteria. Median birth weight and gestational age were 2595 grams (range 575-4255) and 35 weeks (range 24-41) with 10 infants being < 30 weeks gestation. The most common primary underlying diagnosis was congenital heart disease (n = 10). The median age at initial diagnosis was 16 days (range 6-84 days). Renal ultrasonography findings were compatible with possible fungal disease in 15 of the 26 infants (58%) in whom it was performed. Treatment was variable, but fluconazole and either amphotericin B deoxycholate or lipid-based amphotericin B in combination or sequentially were used most frequently. Extra-renal candidiasis subsequently developed in 4 infants. In 2 of these 4 infants, dissemination happened during prolonged courses of anti-fungal therapy. Three of 9 deaths were considered to be related to candidal infection. No recurrences of candiduria or episodes of invasive candidiasis following treatment were documented.Conclusion: Candidal UTI in the NICU population occurs both in term infants with congenital abnormalities and in preterm infants, and is associated with renal parenchymal disease and extra-renal dissemination. A wide variation in clinical approach was documented in this multicenter study. The overall mortality rate in these infants was significant (30%). In one third of the deaths, Candida infection was deemed to be a contributing factor, suggesting the need for antifungal therapy with repeat evaluation for dissemination in infants who are slow to respond to therapy. [ABSTRACT FROM AUTHOR]- Published
- 2009
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