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2. Global Carbon Budget 2023

Author

Integr. Assessm. Global Environm. Change, Environmental Sciences, Friedlingstein, P., O'Sullivan, M., Jones, M. W., Andrew, R. M., Bakker, D. C. E., Hauck, J., Landschützer, P., Le Quéré, C., Luijkx, I. T., Peters, G. P., Peters, W., Pongratz, J., Schwingshackl, C., Sitch, S., Canadell, J. G., Ciais, P., Jackson, R. B., Alin, S. R., Anthoni, P., Barbero, L., Bates, N. R., Becker, M., Bellouin, N., Decharme, B., Bopp, L., Brasika, I. B. M., Cadule, P., Chamberlain, M. A., Chandra, N., Chau, T.-T.-T., Chevallier, F., Chini, L. P., Cronin, M., Dou, X., Enyo, K., Evans, W., Falk, S., Feely, R. A., Feng, L., Ford, D. J., Gasser, T., Ghattas, J., Gkritzalis, T., Grassi, G., Gregor, L., Gruber, N., Gürses, Ö., Harris, I., Hefner, M., Heinke, J., Houghton, R. A., Hurtt, G. C., Iida, Y., Ilyina, T., Jacobson, A. R., Jain, A., Jarníková, T., Jersild, A., Jiang, F., Jin, Z., Joos, F., Kato, E., Keeling, R. F., Kennedy, D., Klein Goldewijk, K., Knauer, J., Korsbakken, J. I., Körtzinger, A., Lan, X., Lefèvre, N., Li, H., Liu, J., Liu, Z., Ma, L., Marland, G., Mayot, N., McGuire, P. C., McKinley, G. A., Meyer, G., Morgan, E. J., Munro, D. R., Nakaoka, S.-I., Niwa, Y., O'Brien, K. M., Olsen, A., Omar, A. M., Ono, T., Paulsen, M., Pierrot, D., Pocock, K., Poulter, B., Powis, C. M., Rehder, G., Resplandy, L., Robertson, E., Rödenbeck, C., Rosan, T. M., Schwinger, J., Séférian, R., Smallman, T. L., Smith, S. M., Sospedra-Alfonso, R., Sun, Q., Sutton, A. J., Sweeney, C., Takao, S., Tans, P. P., Tian, H., Tilbrook, B., Tsujino, H., Tubiello, F., van der Werf, G. R., van Ooijen, E., Wanninkhof, R., Watanabe, M., Wimart-Rousseau, C., Yang, D., Yang, X., Yuan, W., Yue, X., Zaehle, S., Zeng, J., Zheng, B., Integr. Assessm. Global Environm. Change, Environmental Sciences, Friedlingstein, P., O'Sullivan, M., Jones, M. W., Andrew, R. M., Bakker, D. C. E., Hauck, J., Landschützer, P., Le Quéré, C., Luijkx, I. T., Peters, G. P., Peters, W., Pongratz, J., Schwingshackl, C., Sitch, S., Canadell, J. G., Ciais, P., Jackson, R. B., Alin, S. R., Anthoni, P., Barbero, L., Bates, N. R., Becker, M., Bellouin, N., Decharme, B., Bopp, L., Brasika, I. B. M., Cadule, P., Chamberlain, M. A., Chandra, N., Chau, T.-T.-T., Chevallier, F., Chini, L. P., Cronin, M., Dou, X., Enyo, K., Evans, W., Falk, S., Feely, R. A., Feng, L., Ford, D. J., Gasser, T., Ghattas, J., Gkritzalis, T., Grassi, G., Gregor, L., Gruber, N., Gürses, Ö., Harris, I., Hefner, M., Heinke, J., Houghton, R. A., Hurtt, G. C., Iida, Y., Ilyina, T., Jacobson, A. R., Jain, A., Jarníková, T., Jersild, A., Jiang, F., Jin, Z., Joos, F., Kato, E., Keeling, R. F., Kennedy, D., Klein Goldewijk, K., Knauer, J., Korsbakken, J. I., Körtzinger, A., Lan, X., Lefèvre, N., Li, H., Liu, J., Liu, Z., Ma, L., Marland, G., Mayot, N., McGuire, P. C., McKinley, G. A., Meyer, G., Morgan, E. J., Munro, D. R., Nakaoka, S.-I., Niwa, Y., O'Brien, K. M., Olsen, A., Omar, A. M., Ono, T., Paulsen, M., Pierrot, D., Pocock, K., Poulter, B., Powis, C. M., Rehder, G., Resplandy, L., Robertson, E., Rödenbeck, C., Rosan, T. M., Schwinger, J., Séférian, R., Smallman, T. L., Smith, S. M., Sospedra-Alfonso, R., Sun, Q., Sutton, A. J., Sweeney, C., Takao, S., Tans, P. P., Tian, H., Tilbrook, B., Tsujino, H., Tubiello, F., van der Werf, G. R., van Ooijen, E., Wanninkhof, R., Watanabe, M., Wimart-Rousseau, C., Yang, D., Yang, X., Yuan, W., Yue, X., Zaehle, S., Zeng, J., and Zheng, B.

Published
2023

4. Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

Author

Baxter, J. S. (Joseph S.), Johnson, N. (Nichola), Tomczyk, K. (Katarzyna), Gillespie, A. (Andrea), Maguire, S. (Sarah), Brough, R. (Rachel), Fachal, L. (Laura), Michailidou, K. (Kyriaki), Bolla, M. K. (Manjeet K.), Wang, Q. (Qin), Dennis, J. (Joe), Ahearn, T. U. (Thomas U.), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Antonenkova, N. N. (Natalia N.), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Augustinsson, A. (Annelie), Becher, H. (Heiko), Beckmann, M. W. (Matthias W.), Behrens, S. (Sabine), Benitez, J. (Javier), Bermisheva, M. (Marina), Bogdanova, N. V. (Natalia, V), Bojesen, S. E. (Stig E.), Brenner, H. (Hermann), Brucker, S. Y. (Sara Y.), Cai, Q. (Qiuyin), Campa, D. (Daniele), Canzian, F. (Federico), Castelao, J. E. (Jose E.), Chan, T. L. (Tsun L.), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Chenevix-Trench, G. (Georgia), Choi, J.-Y. (Ji-Yeob), Clarke, C. L. (Christine L.), Collaborators, N. (Nbcs), Colonna, S. (Sarah), Conroy, D. M. (Don M.), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Devilee, P. (Peter), Doerk, T. (Thilo), Dossus, L. (Laure), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Ekici, A. B. (Arif B.), Eliassen, A. H. (A. Heather), Engel, C. (Christoph), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Flyger, H. (Henrik), Gago-Dominguez, M. (Manuela), Gao, C. (Chi), Garcia-Closas, M. (Montserrat), Garcia-Saenz, J. A. (Jose A.), Ghoussaini, M. (Maya), Giles, G. G. (Graham G.), Goldberg, M. S. (Mark S.), Gonzalez-Neira, A. (Anna), Guenel, P. (Pascal), Guendert, M. (Melanie), Haeberle, L. (Lothar), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hall, P. (Per), Hamann, U. (Ute), Hartman, M. (Mikael), Hatse, S. (Sigrid), Hauke, J. (Jan), Hollestelle, A. (Antoinette), Hoppe, R. (Reiner), Hopper, J. L. (John L.), Hou, M.-F. (Ming-Feng), Ito, H. (Hidemi), Iwasaki, M. (Motoki), Jager, A. (Agnes), Jakubowska, A. (Anna), Janni, W. (Wolfgang), John, E. M. (Esther M.), Joseph, V. (Vijai), Jung, A. (Audrey), Kaaks, R. (Rudolf), Kang, D. (Daehee), Keeman, R. (Renske), Khusnutdinova, E. (Elza), Kim, S.-W. (Sung-Won), Kosma, V.-M. (Veli-Matti), Kraft, P. (Peter), Kristensen, V. N. (Vessela N.), Kubelka-Sabit, K. (Katerina), Kurian, A. W. (Allison W.), Kwong, A. (Ava), Lacey, J. V. (James, V), Lambrechts, D. (Diether), Larson, N. L. (Nicole L.), Larsson, S. C. (Susanna C.), Le Marchand, L. (Loic), Lejbkowicz, F. (Flavio), Li, J. (Jingmei), Long, J. (Jirong), Lophatananon, A. (Artitaya), LubiNski, J. (Jan), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Manoukian, S. (Siranoush), Margolin, S. (Sara), Matsuo, K. (Keitaro), Mavroudis, D. (Dimitrios), Mayes, R. (Rebecca), Menon, U. (Usha), Milne, R. L. (Roger L.), Taib, N. A. (Nur Aishah Mohd), Muir, K. (Kenneth), Muranen, T. A. (Taru A.), Murphy, R. A. (Rachel A.), Nevanlinna, H. (Heli), O'Brien, K. M. (Katie M.), Offit, K. (Kenneth), Olson, J. E. (Janet E.), Olsson, H. (Hakan), Park, S. K. (Sue K.), Park-Simon, T.-W. (Tjoung-Won), Patel, A. V. (Alpa, V), Peterlongo, P. (Paolo), Peto, J. (Julian), Plaseska-Karanfilska, D. (Dijana), Presneau, N. (Nadege), Pylkäs, K. (Katri), Rack, B. (Brigitte), Rennert, G. (Gad), Romero, A. (Atocha), Ruebner, M. (Matthias), Ruediger, T. (Thomas), Saloustros, E. (Emmanouil), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Schmidt, M. K. (Marjanka K.), Schmutzler, R. K. (Rita K.), Schneeweiss, A. (Andreas), Schoemaker, M. J. (Minouk J.), Shah, M. (Mitul), Shen, C.-Y. (Chen-Yang), Shu, X.-O. (Xiao-Ou), Simard, J. (Jacques), Southey, M. C. (Melissa C.), Stone, J. (Jennifer), Surowy, H. (Harald), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Tapper, W. J. (William J.), Taylor, J. A. (Jack A.), Teo, S. H. (Soo Hwang), Teras, L. R. (Lauren R.), Terry, M. B. (Mary Beth), Toland, A. E. (Amanda E.), Tomlinson, I. (Ian), Truong, T. (Therese), Tseng, C.-C. (Chiu-Chen), Untch, M. (Michael), Vachon, C. M. (Celine M.), van den Ouweland, A. M. (Ans M. W.), Wang, S. S. (Sophia S.), Weinberg, C. R. (Clarice R.), Wendt, C. (Camilla), Winham, S. J. (Stacey J.), Winqvist, R. (Robert), Wolk, A. (Alicja), Wu, A. H. (Anna H.), Yamaji, T. (Taiki), Zheng, W. (Wei), Ziogas, A. (Argyrios), Pharoah, P. D. (Paul D. P.), Dunning, A. M. (Alison M.), Easton, D. F. (Douglas F.), Pettitt, S. J. (Stephen J.), Lord, C. J. (Christopher J.), Haider, S. (Syed), Orr, N. (Nick), Fletcher, O. (Olivia), Baxter, J. S. (Joseph S.), Johnson, N. (Nichola), Tomczyk, K. (Katarzyna), Gillespie, A. (Andrea), Maguire, S. (Sarah), Brough, R. (Rachel), Fachal, L. (Laura), Michailidou, K. (Kyriaki), Bolla, M. K. (Manjeet K.), Wang, Q. (Qin), Dennis, J. (Joe), Ahearn, T. U. (Thomas U.), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Antonenkova, N. N. (Natalia N.), Arndt, V. (Volker), Aronson, K. J. (Kristan J.), Augustinsson, A. (Annelie), Becher, H. (Heiko), Beckmann, M. W. (Matthias W.), Behrens, S. (Sabine), Benitez, J. (Javier), Bermisheva, M. (Marina), Bogdanova, N. V. (Natalia, V), Bojesen, S. E. (Stig E.), Brenner, H. (Hermann), Brucker, S. Y. (Sara Y.), Cai, Q. (Qiuyin), Campa, D. (Daniele), Canzian, F. (Federico), Castelao, J. E. (Jose E.), Chan, T. L. (Tsun L.), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Chenevix-Trench, G. (Georgia), Choi, J.-Y. (Ji-Yeob), Clarke, C. L. (Christine L.), Collaborators, N. (Nbcs), Colonna, S. (Sarah), Conroy, D. M. (Don M.), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cross, S. S. (Simon S.), Czene, K. (Kamila), Daly, M. B. (Mary B.), Devilee, P. (Peter), Doerk, T. (Thilo), Dossus, L. (Laure), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Ekici, A. B. (Arif B.), Eliassen, A. H. (A. Heather), Engel, C. (Christoph), Fasching, P. A. (Peter A.), Figueroa, J. (Jonine), Flyger, H. (Henrik), Gago-Dominguez, M. (Manuela), Gao, C. (Chi), Garcia-Closas, M. (Montserrat), Garcia-Saenz, J. A. (Jose A.), Ghoussaini, M. (Maya), Giles, G. G. (Graham G.), Goldberg, M. S. (Mark S.), Gonzalez-Neira, A. (Anna), Guenel, P. (Pascal), Guendert, M. (Melanie), Haeberle, L. (Lothar), Hahnen, E. (Eric), Haiman, C. A. (Christopher A.), Hall, P. (Per), Hamann, U. (Ute), Hartman, M. (Mikael), Hatse, S. (Sigrid), Hauke, J. (Jan), Hollestelle, A. (Antoinette), Hoppe, R. (Reiner), Hopper, J. L. (John L.), Hou, M.-F. (Ming-Feng), Ito, H. (Hidemi), Iwasaki, M. (Motoki), Jager, A. (Agnes), Jakubowska, A. (Anna), Janni, W. (Wolfgang), John, E. M. (Esther M.), Joseph, V. (Vijai), Jung, A. (Audrey), Kaaks, R. (Rudolf), Kang, D. (Daehee), Keeman, R. (Renske), Khusnutdinova, E. (Elza), Kim, S.-W. (Sung-Won), Kosma, V.-M. (Veli-Matti), Kraft, P. (Peter), Kristensen, V. N. (Vessela N.), Kubelka-Sabit, K. (Katerina), Kurian, A. W. (Allison W.), Kwong, A. (Ava), Lacey, J. V. (James, V), Lambrechts, D. (Diether), Larson, N. L. (Nicole L.), Larsson, S. C. (Susanna C.), Le Marchand, L. (Loic), Lejbkowicz, F. (Flavio), Li, J. (Jingmei), Long, J. (Jirong), Lophatananon, A. (Artitaya), LubiNski, J. (Jan), Mannermaa, A. (Arto), Manoochehri, M. (Mehdi), Manoukian, S. (Siranoush), Margolin, S. (Sara), Matsuo, K. (Keitaro), Mavroudis, D. (Dimitrios), Mayes, R. (Rebecca), Menon, U. (Usha), Milne, R. L. (Roger L.), Taib, N. A. (Nur Aishah Mohd), Muir, K. (Kenneth), Muranen, T. A. (Taru A.), Murphy, R. A. (Rachel A.), Nevanlinna, H. (Heli), O'Brien, K. M. (Katie M.), Offit, K. (Kenneth), Olson, J. E. (Janet E.), Olsson, H. (Hakan), Park, S. K. (Sue K.), Park-Simon, T.-W. (Tjoung-Won), Patel, A. V. (Alpa, V), Peterlongo, P. (Paolo), Peto, J. (Julian), Plaseska-Karanfilska, D. (Dijana), Presneau, N. (Nadege), Pylkäs, K. (Katri), Rack, B. (Brigitte), Rennert, G. (Gad), Romero, A. (Atocha), Ruebner, M. (Matthias), Ruediger, T. (Thomas), Saloustros, E. (Emmanouil), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Schmidt, M. K. (Marjanka K.), Schmutzler, R. K. (Rita K.), Schneeweiss, A. (Andreas), Schoemaker, M. J. (Minouk J.), Shah, M. (Mitul), Shen, C.-Y. (Chen-Yang), Shu, X.-O. (Xiao-Ou), Simard, J. (Jacques), Southey, M. C. (Melissa C.), Stone, J. (Jennifer), Surowy, H. (Harald), Swerdlow, A. J. (Anthony J.), Tamimi, R. M. (Rulla M.), Tapper, W. J. (William J.), Taylor, J. A. (Jack A.), Teo, S. H. (Soo Hwang), Teras, L. R. (Lauren R.), Terry, M. B. (Mary Beth), Toland, A. E. (Amanda E.), Tomlinson, I. (Ian), Truong, T. (Therese), Tseng, C.-C. (Chiu-Chen), Untch, M. (Michael), Vachon, C. M. (Celine M.), van den Ouweland, A. M. (Ans M. W.), Wang, S. S. (Sophia S.), Weinberg, C. R. (Clarice R.), Wendt, C. (Camilla), Winham, S. J. (Stacey J.), Winqvist, R. (Robert), Wolk, A. (Alicja), Wu, A. H. (Anna H.), Yamaji, T. (Taiki), Zheng, W. (Wei), Ziogas, A. (Argyrios), Pharoah, P. D. (Paul D. P.), Dunning, A. M. (Alison M.), Easton, D. F. (Douglas F.), Pettitt, S. J. (Stephen J.), Lord, C. J. (Christopher J.), Haider, S. (Syed), Orr, N. (Nick), and Fletcher, O. (Olivia)

Abstract

A combination of genetic and functional approaches has identified three independent breast cancer risk loci at 2q35. A recent fine-scale mapping analysis to refine these associations resulted in 1 (signal 1), 5 (signal 2), and 42 (signal 3) credible causal variants at these loci. We used publicly available in silico DNase I and ChIP-seq data with in vitro reporter gene and CRISPR assays to annotate signals 2 and 3. We identified putative regulatory elements that enhanced cell-type-specific transcription from the IGFBP5 promoter at both signals (30- to 40-fold increased expression by the putative regulatory element at signal 2, 2- to 3-fold by the putative regulatory element at signal 3). We further identified one of the five credible causal variants at signal 2, a 1.4 kb deletion (esv3594306), as the likely causal variant; the deletion allele of this variant was associated with an average additional increase in IGFBP5 expression of 1.3-fold (MCF-7) and 2.2-fold (T-47D). We propose a model in which the deletion allele of esv3594306 juxtaposes two transcription factor binding regions (annotated by estrogen receptor alpha ChIP-seq peaks) to generate a single extended regulatory element. This regulatory element increases cell-type-specific expression of the tumor suppressor gene IGFBP5 and, thereby, reduces risk of estrogen receptor-positive breast cancer (odds ratio = 0.77, 95% CI 0.74–0.81, p = 3.1 × 10−31).

Published
2021

5. Determining Possible Building Blocks of the Earth

Author

Burbine, T. H and O'Brien, K. M

Subjects
Lunar And Planetary Science And Exploration
Abstract

Introduction: One of the fundamental questions concerning the formation of the Earth is what is it made out of. The Earth appears to have condensed out of material from the solar nebula. We sample this "primitive" material in the form of chondritic meteorites. One of the most important constraints on possible building blocks for the Earth is the Earth#s oxygen iso-topic composition. Rocks from the Earth and Moon plot along a line (the terrestrial fractionation line) in diagrams of delta(sup 17)O (% relative to Standard Mean Ocean Water or SMOW) versus delta(sup 18)O (% relative to SMOW). Chondritic meteorites fall above and below this line. Distances from this line are given as Delta(sup 17)O (%) (= delta(sup 17)O - 0.52 x delta(sup 18)O).

Published
2003

6. Oncologic treatment strategies and relative survival of patients with stage I-III rectal cancer - A EURECCA international comparison between the Netherlands, Belgium, Denmark, Sweden, England, Ireland, Spain, and Lithuania

Author

Breugom, A. J., Bastiaannet, E., Boelens, P. G., Van Eycken, E., Iversen, L. H., Martling, A., Johansson, Robert, Evans, T., Lawton, S., O'Brien, K. M., Ortiz, H., Janciauskiene, R., Dekkers, O. M., Rutten, H. J. T., Liefers, G. J., Lemmens, V. E. P. P., van de Velde, C. J. H., Breugom, A. J., Bastiaannet, E., Boelens, P. G., Van Eycken, E., Iversen, L. H., Martling, A., Johansson, Robert, Evans, T., Lawton, S., O'Brien, K. M., Ortiz, H., Janciauskiene, R., Dekkers, O. M., Rutten, H. J. T., Liefers, G. J., Lemmens, V. E. P. P., and van de Velde, C. J. H.

Abstract

Introduction: The aim of this EURECCA international comparison is to compare oncologic treatment strategies and relative survival of patients with stage I-III rectal cancer between European countries. Material and methods: Population-based national cohort data from the Netherlands (NL), Belgium (BE), Denmark (DK), Sweden (SE), England (ENG), Ireland (IE), Spain (ES), and single-centre data from Lithuania (LT) were obtained. All operated patients with (y)pTNM stage I-III rectal cancer diagnosed between 2004 and 2009 were included. Oncologic treatment strategies and relative survival were calculated and compared between neighbouring countries. Results: We included 57,120 patients. Treatment strategies differed between NL and BE (p < 0.001), DK and SE (p < 0.001), and ENG and IE (p < 0.001). More preoperative radiotherapy as single treatment before surgery was administered in NL compared with BE (59.7% vs. 13.1%), in SE compared with DK (55.1% vs. 10.4%), and in ENG compared with IE (15.2% vs. 9.6%). Less postoperative chemotherapy was given in NL (9.6% vs. 39.1%), in SE (7.9% vs. 14.1%), and in IE (12.6% vs. 18.5%) compared with their neighbouring country. In ES, 55.1% of patients received preoperative chemoradiation and 62.3% post-operative chemotherapy. There were no significant differences in relative survival between neighbouring countries. Conclusion: Large differences in oncologic treatment strategies for patients with (y)pTNM I-III rectal cancer were observed across European countries. No clear relation between oncologic treatment strategies and relative survival was observed. Further research into selection criteria for specific treatments could eventually lead to individualised and optimal treatment for patients with non-metastasised rectal cancer.

Published
2018
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7. Adjuvant chemotherapy and relative survival of patients with stage II colon cancer - A EURECCA international comparison between the Netherlands, Denmark, Sweden, England, Ireland, Belgium, and Lithuania

Author

Breugom, A. J., Bastiaannet, E., Boelens, P. G., Iversen, L. H., Martling, A., Johansson, R., Evans, T., Lawton, S., O'Brien, K. M., Van Eycken, E., Janciauskiene, R., Liefers, G. J., Cervantes, A., Lemmens, V. E. P. P., van de Velde, C. J. H., Breugom, A. J., Bastiaannet, E., Boelens, P. G., Iversen, L. H., Martling, A., Johansson, R., Evans, T., Lawton, S., O'Brien, K. M., Van Eycken, E., Janciauskiene, R., Liefers, G. J., Cervantes, A., Lemmens, V. E. P. P., and van de Velde, C. J. H.

Abstract

Background: The aim of the present EURECCA international comparison is to compare adjuvant chemotherapy and relative survival of patients with stage II colon cancer between European countries. Methods: Population-based national cohort data (2004-2009) from the Netherlands (NL), Denmark (DK), Sweden (SE), England (ENG), Ireland (IE), and Belgium (BE) were obtained, as well as single-centre data from Lithuania. All surgically treated patients with stage II colon cancer were included. The proportion of patients receiving adjuvant chemotherapy was calculated and compared between countries. Besides, relative survival was calculated and compared between countries. Results: Overall, 59,154 patients were included. The proportion of patients receiving adjuvant chemotherapy ranged from 7.1% to 29.0% (p < 0.001). Compared with NL, a better adjusted relative survival was observed in SE (stage II: relative excess risks (RER) 0.53, 95% confidence interval (CI) 0.44-0.64; p < 0.001), and BE (stage II: RER 0.84, 95% CI 0.76-0.92; p < 0.001), and in IE for patients with stage IIA disease (RER 0.80, 95% CI 0.65-0.98; p = 0.03). Conclusion: The proportion of patients with stage II colon cancer receiving adjuvant chemotherapy varied largely between seven European countries. No clear linear pattern between adjuvant chemotherapy and adjusted relative survival was observed. Compared with NL, SE and BE showed an improved adjusted relative survival for stage II disease, and IE for patients with stage IIA disease only. Further research into selection criteria for adjuvant chemotherapy could eventually lead to individually tailored, optimal treatment of patients with stage II colon cancer.

Published
2016
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9. The Surface Ocean CO2 Atlas (SOCAT) enables detection of changes in the ocean carbon sink

Author

Bakker, D. C. E., Pfeil, B., Smith, K., Hankin, S., Olsen, A., Alin, S. R., Cosca, C., Harasawa, S., Kozyr, A., Nojiri, Y., O'Brien, K. M., Schuster, U., Telszewski, M., Tilbrook, B., Wada, C., Akl, J., Barbero, L., Bates, N.R., Boutin, J., Bozec, Y., Cai, W.-J., Castle, R.D., Chavez, F. P., Chen, L., Chierici, M., Currie, K., de Baar, H.J.W., Evans, W., Feely, R.A., Fransson, A., Gao, Z., Hales, B., Hardman-Mountford, N.J., Hoppema, Mario, Huang, W.-J., Hunt, C. W., Huss, B., Ichikawa, T., Johannessen, T., Jones, E. M., Jones, S.D., Jutterström, S., Kitidis, V., Körtzinger, A., Landschϋtzer, P., Lauvset, S. K., Lefèvre, N., Manke, A. B., Mathis, J.T., Merlivat, L., Metzl, N., Murata, A., Newberger, T., Omar, A.M., Ono, T., Park, G.-H., Paterson, K., Pierrot, D., Ríos,, A.F., Sabine, C.L., Saito, S., Salisbury, J., Sarma, V. V. S. S., Schlitzer, Reiner, Sieger, R., Skjelvan, I., Steinhoff, T., Sullivan, K.F., Sun, H., Sutton, A.J., Suzuki, T., Sweeney, C., Takahashi, T., Tjiputra, J., Tsurushima, N., Van Heuven, S. M. A. C., Vandemark, D., Vlahos, P., Wallace, D. W. R., Wanninkhof, R., Watson, A. J., Bakker, D. C. E., Pfeil, B., Smith, K., Hankin, S., Olsen, A., Alin, S. R., Cosca, C., Harasawa, S., Kozyr, A., Nojiri, Y., O'Brien, K. M., Schuster, U., Telszewski, M., Tilbrook, B., Wada, C., Akl, J., Barbero, L., Bates, N.R., Boutin, J., Bozec, Y., Cai, W.-J., Castle, R.D., Chavez, F. P., Chen, L., Chierici, M., Currie, K., de Baar, H.J.W., Evans, W., Feely, R.A., Fransson, A., Gao, Z., Hales, B., Hardman-Mountford, N.J., Hoppema, Mario, Huang, W.-J., Hunt, C. W., Huss, B., Ichikawa, T., Johannessen, T., Jones, E. M., Jones, S.D., Jutterström, S., Kitidis, V., Körtzinger, A., Landschϋtzer, P., Lauvset, S. K., Lefèvre, N., Manke, A. B., Mathis, J.T., Merlivat, L., Metzl, N., Murata, A., Newberger, T., Omar, A.M., Ono, T., Park, G.-H., Paterson, K., Pierrot, D., Ríos,, A.F., Sabine, C.L., Saito, S., Salisbury, J., Sarma, V. V. S. S., Schlitzer, Reiner, Sieger, R., Skjelvan, I., Steinhoff, T., Sullivan, K.F., Sun, H., Sutton, A.J., Suzuki, T., Sweeney, C., Takahashi, T., Tjiputra, J., Tsurushima, N., Van Heuven, S. M. A. C., Vandemark, D., Vlahos, P., Wallace, D. W. R., Wanninkhof, R., and Watson, A. J.

Published
2015

10. Telephone-based weight loss support for patients with knee osteoarthritis: a pragmatic randomised controlled trial.

Author

O'Brien, K.M., Wiggers, J., Williams, A., Campbell, E., Hodder, R.K., Wolfenden, L., Yoong, S.L., Robson, E.K., Haskins, R., Kamper, S.J., Rissel, C., Williams, C.M., and O'Brien, K M

Abstract

Objective: To determine the effectiveness of telephone-based weight loss support in reducing the intensity of knee pain in patients with knee osteoarthritis, who are overweight or obese, compared to usual care.Design: We conducted a parallel randomised controlled trial (RCT), embedded within a cohort multiple RCT of patients on a waiting list for outpatient orthopaedic consultation at a tertiary referral hospital in NSW, Australia. Patients with knee osteoarthritis, classified as overweight or obese [body mass index (BMI) between ≥27 kg/m2 and <40 kg/m2] were randomly allocated to receive referral to an existing non-disease specific government funded 6-month telephone-based weight management and healthy lifestyle service or usual care. The primary outcome was knee pain intensity measured using an 11-point numerical rating scale (NRS) over 6-month follow-up. A number of secondary outcomes, including self-reported weight were measured. Data analysis was by intention-to-treat according to a pre-published analysis plan.Results: Between May 19 and June 30 2015, 120 patients were randomly assigned to the intervention (59 analysed, one post-randomisation exclusion) or usual care (60 analysed). We found no statistically significant between group differences in pain intensity [area under the curve (AUC), mean difference 5.4, 95%CI: -13.7 to 24.5, P = 0.58] or weight change at 6 months (self-reported; mean difference -0.4, 95%CI: -2.6 to 1.8, P = 0.74).Conclusions: Among patients with knee osteoarthritis who are overweight, telephone-based weight loss support, provided using an existing 6-month weight management and healthy lifestyle service did not reduce knee pain intensity or weight, compared with usual care.Trial Registration Number: ACTRN12615000490572. [ABSTRACT FROM AUTHOR]

Published
2018
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11. Informal caregiving in head and neck cancer: caregiving activities and psychological well‐being.

Author

Balfe, M., O'Brien, K. M., Timmons, A., Butow, P., O'Sullivan, E., Gooberman‐Hill, R., and Sharp, L.

Subjects
*HEAD tumors, *NECK tumors, *ANXIETY, *PSYCHOLOGY of caregivers, *CHI-squared test, *CONFIDENCE intervals, *MENTAL depression, *DRUG administration, *ECONOMICS, *HUMAN comfort, *MEDICAL appointments, *PROBABILITY theory, *QUESTIONNAIRES, *RESEARCH funding, *SOCIAL role, *PSYCHOLOGICAL stress, *TIME, *HOUSEKEEPING, *ACTIVITIES of daily living, *MULTIPLE regression analysis, *WELL-being, *DATA analysis software, *DESCRIPTIVE statistics, *ODDS ratio, *TUMOR treatment
Abstract

The purpose of this study was to quantify the general cancer support activities that long‐term carers of head and neck cancer (HNC) survivors engage in; and the relationships between these care activities and psychological well‐being. Respondents answered a survey detailing their caring activities, the amount of time that they spent on those activities and how comfortable they felt engaging in them. Psychological well‐being was assessed by the Depression Anxiety Stress Scales‐21. A total of 197 carers took part in the study. The majority (76%) were women, mean age 57.4. Mean time since diagnosis was 6.2 years. In the past month, 45% of carers did not spend any extra time per week helping their relative/friend with general caring activities such as cleaning the house; 31% spent 1–19 hr/week and 23% spent 20 or more hours/week doing so. Most carers were comfortable assisting their relative/friend, though more carers felt uncomfortable assisting with HNC‐specific support tasks (31% uncomfortable helping with medication) compared with general support tasks (7% uncomfortable helping with appointments). Feeling uncomfortable with head and neck‐specific care tasks was a significant predictor of experiencing depression and anxiety. [ABSTRACT FROM AUTHOR]

Published
2018
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13. An update to the Surface Ocean CO2 Atlas (SOCAT version 2)

Author

Bakker, D. C. E., Pfeil, B., Smith, K., Hankin, S., Olsen, A., Alin, S. R., Cosca, C., Harasawa, S., Kozyr, A., Nojiri, Y., O'Brien, K. M., Schuster, U., Telszewski, M., Tilbrook, B., Wada, C., Akl, J., Barbero, L., Bates, N. R., Boutin, J., Bozec, Y., Cai, W. -j., Castle, R. D., Chavez, F. P., Chen, L., Chierici, M., Currie, K., De Baar, H. J. W., Evans, W., Feely, R. A., Fransson, A., Gao, Z., Hales, B., Hardman-mountford, N. J., Hoppema, M., Huang, W. -j., Hunt, C. W., Huss, B., Ichikawa, T., Johannessen, T., Jones, E. M., Jones, S. D., Jutterstrom, S., Kitidis, V., Koertzinger, A., Landschuetzer, P., Lauvset, S. K., Lefevre, N., Manke, A. B., Mathis, J. T., Merlivat, L., Metzl, N., Murata, A., Newberger, T., Omar, A. M., Ono, T., Park, G. -h., Paterson, K., Pierrot, D., Rios, A. F., Sabine, C. L., Saito, S., Salisbury, J., Sarma, V. V. S. S., Schlitzer, R., Sieger, R., Skjelvan, I., Steinhoff, T., Sullivan, K. F., Sun, H., Sutton, A. J., Suzuki, T., Sweeney, C., Takahashi, T., Tjiputra, J., Tsurushima, N., Van Heuven, S. M. A. C., Vandemark, D., Vlahos, P., Wallace, D. W. R., Wanninkhof, R., Watson, A. J., Bakker, D. C. E., Pfeil, B., Smith, K., Hankin, S., Olsen, A., Alin, S. R., Cosca, C., Harasawa, S., Kozyr, A., Nojiri, Y., O'Brien, K. M., Schuster, U., Telszewski, M., Tilbrook, B., Wada, C., Akl, J., Barbero, L., Bates, N. R., Boutin, J., Bozec, Y., Cai, W. -j., Castle, R. D., Chavez, F. P., Chen, L., Chierici, M., Currie, K., De Baar, H. J. W., Evans, W., Feely, R. A., Fransson, A., Gao, Z., Hales, B., Hardman-mountford, N. J., Hoppema, M., Huang, W. -j., Hunt, C. W., Huss, B., Ichikawa, T., Johannessen, T., Jones, E. M., Jones, S. D., Jutterstrom, S., Kitidis, V., Koertzinger, A., Landschuetzer, P., Lauvset, S. K., Lefevre, N., Manke, A. B., Mathis, J. T., Merlivat, L., Metzl, N., Murata, A., Newberger, T., Omar, A. M., Ono, T., Park, G. -h., Paterson, K., Pierrot, D., Rios, A. F., Sabine, C. L., Saito, S., Salisbury, J., Sarma, V. V. S. S., Schlitzer, R., Sieger, R., Skjelvan, I., Steinhoff, T., Sullivan, K. F., Sun, H., Sutton, A. J., Suzuki, T., Sweeney, C., Takahashi, T., Tjiputra, J., Tsurushima, N., Van Heuven, S. M. A. C., Vandemark, D., Vlahos, P., Wallace, D. W. R., Wanninkhof, R., and Watson, A. J.

Abstract

The Surface Ocean CO2 Atlas (SOCAT), an activity of the international marine carbon research community, provides access to synthesis and gridded fCO(2) (fugacity of carbon dioxide) products for the surface oceans. Version 2 of SOCAT is an update of the previous release (version 1) with more data (increased from 6.3 million to 10.1 million surface water fCO(2) values) and extended data coverage (from 1968-2007 to 1968-2011). The quality control criteria, while identical in both versions, have been applied more strictly in version 2 than in version 1. The SOCAT website (http://www.socat.info/) has links to quality control comments, metadata, individual data set files, and synthesis and gridded data products. Interactive online tools allow visitors to explore the richness of the data. Applications of SOCAT include process studies, quantification of the ocean carbon sink and its spatial, seasonal, year-to-year and longer-term variation, as well as initialisation or validation of ocean carbon models and coupled climate-carbon models.

Published
2014
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14. An update to the Surface Ocean CO&lt;sub&gt;2&lt;/sub&gt; Atlas (SOCAT version 2)

Author

Bakker, D. C. E., primary, Pfeil, B., additional, Smith, K., additional, Hankin, S., additional, Olsen, A., additional, Alin, S. R., additional, Cosca, C., additional, Harasawa, S., additional, Kozyr, A., additional, Nojiri, Y., additional, O'Brien, K. M., additional, Schuster, U., additional, Telszewski, M., additional, Tilbrook, B., additional, Wada, C., additional, Akl, J., additional, Barbero, L., additional, Bates, N. R., additional, Boutin, J., additional, Bozec, Y., additional, Cai, W.-J., additional, Castle, R. D., additional, Chavez, F. P., additional, Chen, L., additional, Chierici, M., additional, Currie, K., additional, de Baar, H. J. W., additional, Evans, W., additional, Feely, R. A., additional, Fransson, A., additional, Gao, Z., additional, Hales, B., additional, Hardman-Mountford, N. J., additional, Hoppema, M., additional, Huang, W.-J., additional, Hunt, C. W., additional, Huss, B., additional, Ichikawa, T., additional, Johannessen, T., additional, Jones, E. M., additional, Jones, S. D., additional, Jutterström, S., additional, Kitidis, V., additional, Körtzinger, A., additional, Landschützer, P., additional, Lauvset, S. K., additional, Lefèvre, N., additional, Manke, A. B., additional, Mathis, J. T., additional, Merlivat, L., additional, Metzl, N., additional, Murata, A., additional, Newberger, T., additional, Omar, A. M., additional, Ono, T., additional, Park, G.-H., additional, Paterson, K., additional, Pierrot, D., additional, Ríos, A. F., additional, Sabine, C. L., additional, Saito, S., additional, Salisbury, J., additional, Sarma, V. V. S. S., additional, Schlitzer, R., additional, Sieger, R., additional, Skjelvan, I., additional, Steinhoff, T., additional, Sullivan, K. F., additional, Sun, H., additional, Sutton, A. J., additional, Suzuki, T., additional, Sweeney, C., additional, Takahashi, T., additional, Tjiputra, J., additional, Tsurushima, N., additional, van Heuven, S. M. A. C., additional, Vandemark, D., additional, Vlahos, P., additional, Wallace, D. W. R., additional, Wanninkhof, R., additional, and Watson, A. J., additional

Published
2014
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16. An update to the Surface Ocean CO2 Atlas (SOCAT version 2)

Author

Bakker, D. C. E., Pfeil, B., Smith, K., Hankin, S., Olsen, A., Alin, S. R., Cosca, C., Harasawa, S., Kozyr, A., Nojiri, Y., O'Brien, K. M., Schuster, U., Telszewski, M., Tilbrook, B., Wada, C., Akl, J., Barbero, L., Bates, N., Boutin, J., Cai, W.-J., Castle, R. D., Chavez, F. P., Chen, L., Chierici, M., Currie, K., de Baar, H. J. W., Evans, W., Feely, R. A., Fransson, A., Gao, Z., Hales, B., Hardman-Mountford, N., Hoppema, Mario, Huang, W.-J., Hunt, C. W., Huss, B., Ichikawa, T., Johannessen, T., Jones, Elizabeth M., Jones, S. D., Jutterström, S., Kitidis, V., Körtzinger, A., Landschtzer, P., Lauvset, S. K., Lefèvre, N., Manke, A. B., Mathis, J. T., Merlivat, L., Metzl, N., Murata, A., Newberger, T., Ono, T., Park, G.-H., Paterson, K., Pierrot, D., Ríos, A. F., Sabine, C. L., Saito, S., Salisbury, J., Sarma, V. V. S. S., Schlitzer, Reiner, Sieger, Rainer, Skjelvan, I., Steinhoff, T., Sullivan, K., Sun, H., Sutton, A. J., Suzuki, T., Sweeney, C., Takahashi, T., Tjiputra, J., Tsurushima, N., van Heuven, S. M. A. C., Vandemark, D., Vlahos, P., Wallace, D. W. R., Wanninkhof, R., Watson, A. J., Bakker, D. C. E., Pfeil, B., Smith, K., Hankin, S., Olsen, A., Alin, S. R., Cosca, C., Harasawa, S., Kozyr, A., Nojiri, Y., O'Brien, K. M., Schuster, U., Telszewski, M., Tilbrook, B., Wada, C., Akl, J., Barbero, L., Bates, N., Boutin, J., Cai, W.-J., Castle, R. D., Chavez, F. P., Chen, L., Chierici, M., Currie, K., de Baar, H. J. W., Evans, W., Feely, R. A., Fransson, A., Gao, Z., Hales, B., Hardman-Mountford, N., Hoppema, Mario, Huang, W.-J., Hunt, C. W., Huss, B., Ichikawa, T., Johannessen, T., Jones, Elizabeth M., Jones, S. D., Jutterström, S., Kitidis, V., Körtzinger, A., Landschtzer, P., Lauvset, S. K., Lefèvre, N., Manke, A. B., Mathis, J. T., Merlivat, L., Metzl, N., Murata, A., Newberger, T., Ono, T., Park, G.-H., Paterson, K., Pierrot, D., Ríos, A. F., Sabine, C. L., Saito, S., Salisbury, J., Sarma, V. V. S. S., Schlitzer, Reiner, Sieger, Rainer, Skjelvan, I., Steinhoff, T., Sullivan, K., Sun, H., Sutton, A. J., Suzuki, T., Sweeney, C., Takahashi, T., Tjiputra, J., Tsurushima, N., van Heuven, S. M. A. C., Vandemark, D., Vlahos, P., Wallace, D. W. R., Wanninkhof, R., and Watson, A. J.

Abstract

The Surface Ocean CO2 Atlas (SOCAT) is an effort by the international marine carbon research community. It aims to improve access to carbon dioxide measurements in the surface oceans by regular releases of quality controlled and fully documented synthesis and gridded fCO2 (fugacity of carbon dioxide) products. SOCAT version 2 presented here extends the data set for the global oceans and coastal seas by four years and has 10.1 million surface water fCO2 values from 2660 cruises between 1968 and 2011. The procedures for creating version 2 have been comparable to those for version 1. The SOCAT website (http://www.socat.info/) provides access to the individual cruise data files, as well as to the synthesis and gridded data products. Interactive online tools allow visitors to explore the richness of the data. Scientific users can also retrieve the data as downloadable files or via Ocean Data View. Version 2 enables carbon specialists to expand their studies until 2011. Applications of SOCAT include process studies, quantification of the ocean carbon sink and its spatial, seasonal, year-to-year and longer-term variation, as well as initialisation or validation of ocean carbon models and coupled-climate carbon models.

Published
2013

17. An update to the Surface Ocean CO2 Atlas (SOCAT version 2)

Author

Bakker, D. C. E., primary, Pfeil, B., additional, Smith, K., additional, Hankin, S., additional, Olsen, A., additional, Alin, S. R., additional, Cosca, C., additional, Harasawa, S., additional, Kozyr, A., additional, Nojiri, Y., additional, O'Brien, K. M., additional, Schuster, U., additional, Telszewski, M., additional, Tilbrook, B., additional, Wada, C., additional, Akl, J., additional, Barbero, L., additional, Bates, N., additional, Boutin, J., additional, Cai, W.-J., additional, Castle, R. D., additional, Chavez, F. P., additional, Chen, L., additional, Chierici, M., additional, Currie, K., additional, de Baar, H. J. W., additional, Evans, W., additional, Feely, R. A., additional, Fransson, A., additional, Gao, Z., additional, Hales, B., additional, Hardman-Mountford, N., additional, Hoppema, M., additional, Huang, W.-J., additional, Hunt, C. W., additional, Huss, B., additional, Ichikawa, T., additional, Johannessen, T., additional, Jones, E. M., additional, Jones, S. D., additional, Jutterström, S., additional, Kitidis, V., additional, Körtzinger, A., additional, Landschtzer, P., additional, Lauvset, S. K., additional, Lefèvre, N., additional, Manke, A. B., additional, Mathis, J. T., additional, Merlivat, L., additional, Metzl, N., additional, Murata, A., additional, Newberger, T., additional, Ono, T., additional, Park, G.-H., additional, Paterson, K., additional, Pierrot, D., additional, Ríos, A. F., additional, Sabine, C. L., additional, Saito, S., additional, Salisbury, J., additional, Sarma, V. V. S. S., additional, Schlitzer, R., additional, Sieger, R., additional, Skjelvan, I., additional, Steinhoff, T., additional, Sullivan, K., additional, Sun, H., additional, Sutton, A. J., additional, Suzuki, T., additional, Sweeney, C., additional, Takahashi, T., additional, Tjiputra, J., additional, Tsurushima, N., additional, van Heuven, S. M. A. C., additional, Vandemark, D., additional, Vlahos, P., additional, Wallace, D. W. R., additional, Wanninkhof, R., additional, and Watson, A. J., additional

Published
2013
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23. Using advanced compiler technology to exploit the performance of the Cell Broadband Engine™ architecture

Author

Eichenberger, A. E., primary, O'Brien, J. K., additional, O'Brien, K. M., additional, Wu, P., additional, Chen, T., additional, Oden, P. H., additional, Prener, D. A., additional, Shepherd, J. C., additional, So, B., additional, Sura, Z., additional, Wang, A., additional, Zhang, T., additional, Zhao, P., additional, Gschwind, M. K., additional, Archambault, R., additional, Gao, Y., additional, and Koo, R., additional

Published
2006
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29. Early-life Exposures and Age at Breast Development in the Sister Study Cohort.

Author

Goldberg, M., D'Aloisio, A. A., O'Brien, K. M., Zhao, S., and Sandler, D. P.

Abstract

Purpose: Early age at breast development (thelarche) has been associated with increased breast cancer risk. Average age at thelarche has declined over time, but there are few established risk factors for early thelarche. We examined associations between pre- and postnatal exposures and age at thelarche in a U.S. cohort of women born between 1928 and 1974. Methods: Breast cancer-free women ages 35-74 years who had a sister diagnosed with breast cancer were enrolled in the Sister Study from 2003-2009 (N = 50,884). At enrollment, participants reported their age at thelarche, which we categorized as early (=10 years), average (11-13 years), and late (=14 years), as well as information on early-life exposures. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for early and late thelarche relative to average age at thelarche using polytomous logistic regression for each early-life exposure, adjusted for birth cohort, race/ethnicity and family income level in childhood. We examined modification by birth cohort, race/ethnicity, family income, relative weight at age 10, and extent of breast cancer family history through stratification. Results: Early thelarche was more common in recent birth cohorts and among non-Hispanic Black and Hispanic women. Early thelarche (=10 years) was associated with multiple prenatal exposures: gestational hypertensive disorder (OR = 1.25, 95% CI, 1.09-1.43), maternal diethylstilbestrol (DES) use (OR = 1.23, 95% CI, 1.04-1.45), maternal smoking during pregnancy (OR = 1.20, 95% CI, 1.13-1.27), and young maternal age (OR 1.30, 95% CI, 1.16-1.47 for <20 vs 25-29 years). Being firstborn was also associated with early thelarche (OR = 1.25, 95% CI, 1.17-1.33). Low birthweight (<2500 vs 2500-3999g) was suggestively associated with both early (OR = 1.06, 95% CI, 0.96-1.17) and late (OR = 1.15, 95% CI, 1.05-1.25) thelarche, as was use of soy formula in infancy (Early: OR = 1.10, 95% CI, 0.93-1.30; Late: OR = 1.07, 95% CI, 0.92-1.25). Patterns were generally similar across strata of modifiers of interest. Conclusion: Associations between pre- and postnatal exposures and age at thelarche suggest that the early-life environment may influence breast development and therefore may also affect breast cancer risk by altering the timing of pubertal breast development. [ABSTRACT FROM AUTHOR]

Published
2021
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33. Relationship between Hair Cortisol and Perceived Chronic Stress in a Diverse Sample.

Author

O'Brien, K. M., Tronick, E. Z., and Moore, C. L.

Subjects
*ANALYSIS of covariance, *ANALYSIS of variance, *ATTITUDE (Psychology), *BIOMARKERS, *CHRONIC diseases, *GROUP identity, *HIGH performance liquid chromatography, *HYDROCORTISONE, *MINORITIES, *PROBABILITY theory, *PSYCHOLOGICAL tests, *RESEARCH funding, *PSYCHOLOGICAL stress, *SOCIOECONOMIC factors, *DATA analysis software, *HAIR analysis, *DESCRIPTIVE statistics
Abstract

Hair cortisol (CORT) is a biomarker of chronic stress via long-term alterations in hypothalamus-pituitary-adrenal axis activity. Relationships to perceived stress measures, however, have rarely been specifically investigated. A diverse sample of 135 adults participated in a study assessing relationships between chronic stress indicator CORT to perceived stress and health indicators. CORT was not correlated to single perceived domain indices but with a global stress composite. Differences in objective and subjective measures were found for sociodemographics: racial/ethnic identity, sex and socioeconomic status (SES). Race by SES interactions predicted both CORT and perceived stress, but produced a complex and partially unanticipated pattern of results. For minorities, low and high SES showed the highest CORT, with mid-SES showing the lowest CORT; there was little change in perceived stress at all levels of SES. For non-minorities, mid-SES showed the highest CORT, with decreases in both CORT and perceived stress in high SES. The unanticipated findings of deleterious outcomes for high SES minorities highlight the importance of investigating potential stressors and moderators, including perceived discrimination and social identity. Moreover, these results suggest that CORT may not always correlate with single stress indices but may provide a global assessment of chronic stress, with implications for the allostatic load literature. Copyright © 2012 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2013
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34. An update to the Surface Ocean CO2 Atlas (SOCAT version 2).

Author

Bakker, D. C. E., Pfeil, B., Smith, K., Hankin, S., Olsen, A., Alin, S. R., Cosca, C., S. Harasawa, Kozyr, A., Y. Nojiri, O'Brien, K. M., Schuster, U., Telszewski, M., Tilbrook, B., C. Wada, Akl, J., Barbero, L., Bates, N., Boutin, J., and Cai, W.-J.

Subjects
CARBON content of seawater, CARBON dioxide & the environment, CARBON cycle, OCEANOGRAPHIC research, CARBON & the environment
Abstract

The Surface Ocean C02 Atlas (SOCAT) is an effort by the international marine carbon research community. It aims to improve access to carbon dioxide measurements in the surface oceans by regular releases of quality controlled and fully documented synthesis and gridded fCO2 (fugacity of carbon dioxide) products. SOCAT version 2 presented here extends the data set for the global oceans and coastal seas by four years and has 10.1 million surface water fCO2 values from 2660 cruises between 1968 and 2011. The procedures for creating version 2 have been comparable to those for version 1. The SOCAT website (http://www.socat.info/) provides access to the individual cruise data files, as well as to the synthesis and gridded data products. Interactive online tools allow visitors to explore the richness of the data. Scientific users can also retrieve the data as downloadable files or via Ocean Data View. Version 2 enables carbon specialists to expand their studies until 2011. Applications of SOCAT include process studies, quantification of the ocean carbon sink and its spatial, seasonal, year-to-year and longer-term variation, as well as initialisation or validation of ocean carbon models and coupled-climate carbon models. [ABSTRACT FROM AUTHOR]

Published
2013
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38. Relationship quality of aggressive children and their siblings: a multiinformant, multimeasure investigation.

Author

Aguilar, Benjamin, O'Brien, Kathryn M., August, Gerald J., Aoun, Suzzanne L., Hektner, Joel M., Aguilar, B, O'Brien, K M, August, G J, Aoun, S L, and Hektner, J M

Subjects
SIBLING rivalry, AGGRESSION (Psychology), CONFLICT (Psychology) -- Social aspects, PSYCHOLOGY, BIRTH order, SIBLINGS, CONFLICT (Psychology), GENDER identity, PERSONALITY assessment, PSYCHOLOGICAL factors
Abstract

Sibling influence on the learning and enactment of aggressive behavior has been consistently demonstrated in studies of sibling relationships. Available evidence suggests that, compared with nonaggressive children's sibling interactions, the sibling interactions of aggressive children are marked by more frequent, intense, and prolonged aggressive behaviors. Although research on normative and aggressive children's sibling interactions has increased recently, a number of limitations in this literature were addressed in this study by: (1) including both an aggressive and nonaggressive comparison group, (2) examining both positive and negative features of sibling relationships, (3) employing a multimethod/multiinformant approach to data collection, and (4) utilizing an improved self-report method. In support of our hypotheses and consistent with previous research, results showed that aggressive children's sibling relationships were marked by higher levels of observed conflict and lower levels of self-reported positive features. When gender was examined, results showed that older brother/younger sister dyads were characterized by higher levels of negative features and lower levels of positive features. [ABSTRACT FROM AUTHOR]

Published
2001
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47. Hair Product Use and Ovarian Cancer Risk.

Author

White, A. J., Sandler, D. P., and O'Brien, K. M.

Abstract

Purpose. We evaluated whether hair products, including many known to contain carcinogens and endocrine disrupting chemicals, are related to incident ovarian cancer in a large prospective cohort. Methods. After excluding women with a history of ovarian cancer or bilateral oophorectomy, 40,559 Sister Study participants were included. Participants were aged 35-74 and had a sister with breast cancer but no history of breast cancer themselves at enrollment in 2003-2009. Participants completed questionnaires on frequency of hair product use (including hair dyes, straighteners/relaxers and hair permanents/body waves) in the 12 months prior to enrollment. Cox regression models were used to estimate adjusted hazard ratios (HRs) and 95% Confidence Intervals (CIs) for the association between hair product type and frequency of use in relation to incident ovarian cancer. We also assessed models stratified by tumor type (serous, non-serous). Results. After a mean of 10 years of follow-up, 241 women had self-reported an incident ovarian cancer diagnosis. Ever use of hair products in the past year (including permanent, semi-permanent and temporary hair dyes, straighteners/relaxers, and hair permanents/body waves) was not associated with a higher risk of ovarian cancer. However, frequent use (>4 times) of straighteners/relaxers in the past year was positively associated with ovarian cancer (HR = 2.45, 95% CI: 1.27-4.73). This association was stronger for non-serous (HR = 4.25, 95% CI: 1.07-16.9) compared to serous (HR = 1.38, 95% CI:0.47-4.04) ovarian cancers. Ever use of permanent hair dye was positively associated with non-serous (HR = 1.91, 95% CI, 1.10-3.33), but inversely associated with serous (HR = 0.65, 95% CI: 0.43-0.98) ovarian cancer (p-for-heterogeneity = 0.002). Conclusion. These results suggest that frequent use of hair straighteners/relaxers and possibly permanent hair dye may be positively associated with the occurrence of non-serous ovarian cancers. [ABSTRACT FROM AUTHOR]

Published
2021
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48. Adolescent Use of Hair Dyes, Chemical Straighteners and Perms in Relation to Breast Cancer Risk in the Sister Study.

Author

White, A. J., Taylor, K. W., Eberle, C. E., Gaston, S. A., O'Brien, K. M., Jackson, C. L., and Sandler, D. P.

Abstract

Hair products may contain hormonally active and carcinogenic compounds. We evaluated the risk of breast cancer associated with adolescent use of hair dyes, chemical straighteners and perms in a large prospective U.S. cohort. Methods: Sister Study participants (n = 47,833) were ages 35-74 years and had a sister who had been diagnosed with breast cancer at the time of enrollment (2003-2009). Enrollment questionnaires obtained information on demographics and lifestyle factors as well as frequency of use of hair dyes, chemical straighteners, and perms at ages 10-13 years. Cox proportional hazards models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the association between adolescent hair product use and breast cancer risk (invasive cancer and ductal carcinoma in situ). We considered whether associations varied by invasiveness, estrogen receptor (ER) status of the tumor, menopause status and race. Results: Over an average of 8.3 years of follow-up, 2,829 cases were diagnosed. Hair dye use at ages 10-13 years was uncommon and not associated with breast cancer risk (e.g. permanent hair dye, <3%; HR = 0.96, 95% CI: 0.76-1.22). Use of perms (34% non-Hispanic white vs. 8% black women) and straighteners (10% non-Hispanic white vs 75% black women) at ages 10-13 years varied by race. An elevated HR for breast cancer was observed for frequent use of chemical straighteners (HR = 1.27, 95% CI: 0.98-1.65). Though based on small numbers, this association was most pronounced for ER- invasive (HR = 2.04, 95% CI: 0.98-4.24) and premenopausal breast cancer (HR = 2.18, 95% CI 1.27-3.74). Frequent use of perms was also associated with a higher risk of invasive breast cancer and ER- tumors (HR = 1.25, 95% CI: 1.00-1.57 and HR = 1.69, 95%CI: 0.96-2.98, respectively). Although product use varied by race, associations with breast cancer did not. Conclusions: Frequent use of chemical straighteners or perms during the ages of 10-13 years was associated with a higher risk of breast cancer. These results suggest that exposure to the chemicals in these hair products, especially during adolescence which may be an important biological window of susceptibility, may play a role in breast carcinogenesis. [ABSTRACT FROM AUTHOR]

Published
2020
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49. An update to the Surface Ocean CO₂ Atlas (SOCAT version 2)

Author

Bakker, D. C. E., Pfeil, B., Smith, K., Hankin, S., Olsen, A., Alin, S. R., Cosca, C., Harasawa, S., Kozyr, A., Nojiri, Y., O'Brien, K. M., Schuster, U., Telszewski, M., Tilbrook, B., Wada, C., Akl, J., Barbero, L., Bates, N. R., Boutin, J., Bozec, Y., Cai, W.-J., Castle, R. D., Chavez, F. P., Chen, L., Chierici, M., Currie, K., De Baar, H. J. W., Evans, W., Feely, R. A., Fransson, A., Gao, Z., Hales, B., Hardman-Mountford, N. J., Hoppema, M., Huang, W.-J., Hunt, C. W., Huss, B., Ichikawa, T., Johannessen, T., Jones, E. M., Jones, S. D., Jutterström, S., Kitidis, V., Körtzinger, A., Landschützer, P., Lauvset, S. K., Lefèvre, N., Manke, A. B., Mathis, J. T., Merlivat, L., Metzl, N., Murata, A., Newberger, T., Omar, A. M., Ono, T., Park, G.-H., Paterson, K., Pierrot, D., Ríos, A. F., Sabine, C. L., Saito, S., Salisbury, J., Sarma, V. V. S. S., Schlitzer, R., Sieger, R., Skjelvan, I., Steinhoff, T., Sullivan, K. F., Sun., H., Sutton, A. J., Suzuki, T., Sweeney, C., Takahashi, Taro, Tjiputra, J., Tsurushima, N., Van Heuven, S. M. A. C., Vandemark, D., Vlahos, P., Wallace, D. W. R., Wanninkhof, R., and Watson, A. J.

Subjects
Earth sciences--Data processing, 13. Climate action, Information science, Marine sciences--Research--International cooperation, Chemical oceanography, 14. Life underwater, Hydrology, Carbon dioxide--Environmental aspects--Mathematical models
Abstract

The Surface Ocean CO₂ Atlas (SOCAT), an activity of the international marine carbon research community, provides access to synthesis and gridded fCO₂ (fugacity of carbon dioxide) products for the surface oceans. Version 2 of SOCAT is an update of the previous release (version 1) with more data (increased from 6.3 million to 10.1 million surface water fCO₂ values) and extended data coverage (from 1968–2007 to 1968–2011). The quality control criteria, while identical in both versions, have been applied more strictly in version 2 than in version 1. The SOCAT website (http://www.socat.info/) has links to quality control comments, metadata, individual data set files, and synthesis and gridded data products. Interactive online tools allow visitors to explore the richness of the data. Applications of SOCAT include process studies, quantification of the ocean carbon sink and its spatial, seasonal, year-to-year and longerterm variation, as well as initialisation or validation of ocean carbon models and coupled climate-carbon models.

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