Search

Your search keyword '"O'BRIEN, S. J."' showing total 898 results
Start Over Author "O'BRIEN, S. J."
898 results on '"O'BRIEN, S. J."'

3. Distribution of Molecular Subtypes within Salmonella enterica Serotype Enteritidis Phage Type 4 and S. Typhimurium Definitive Phage Type 104 in Nine European Countries, 2000-2004: Results of an International Multi-Centre Study

Author

Gatto, A. J., Peters, T. M., Green, J., Fisher, I. S. T., Gill, O. N., O'Brien, S. J., Maguire, C., Berghold, C., Lederer, I., Gerner-Smidt, P., Torpdahl, M., Siitonen, A., Lukinmaa, S., Tschäpe, H., Prager, R., Luzzi, I., Dionisi, A. M., Van Der Zwaluw, W. K., Heck, M., Coia, J., Brown, D., Usera, M., Echeita, A., and Threlfall, E. J.

Published
2006

19. The Human Genes that Limit AIDS

Author

O’Brien, S. J., Dean, M., Smith, M., Winkler, C., Nelson, G. W., Martin, M. P., Carrington, M., Boulyjenkov, V., editor, Berg, K., editor, and Christen, Y., editor

Published
2000
Full Text
View/download PDF

35. Cheese And Salmonella Infection

Author

Kerr, K. G., Nice, Christopher S., Lacey, Richard W., Rose, Eric, Campbell, D. M., Cowden, J. M., Morris, G., Reilly, W. J., O'Brien, S. J., and Cunynghame, Arthur

Published
1996

40. Comparative Chromosome Mapping of Musk Ox and the X Chromosome among Some Bovidae Species

Author

Proskuryakova, A A, Kulemzina, A I, Perelman, P L, Yudkin, D V, Lemskaya, N A, Okhlopkov, I M, Kirillin, E V, Farré, M, Larkin, D M, Roelke-Parker, M E, O'Brien, S J, Bush, M, and Graphodatsky, A S

Abstract

Bovidae, the largest family in Pecora infraorder, are characterized by a striking variability in diploid number of chromosomes between species and among individuals within a species. The bovid X chromosome is also remarkably variable, with several morphological types in the family. Here we built a detailed chromosome map of musk ox (Ovibos moschatus), a relic species originating from Pleistocene megafauna, with dromedary and human probes using chromosome painting. We trace chromosomal rearrangements during Bovidae evolution by comparing species already studied by chromosome painting. The musk ox karyotype differs from the ancestral pecoran karyotype by six fusions, one fission, and three inversions. We discuss changes in pecoran ancestral karyotype in the light of new painting data. Variations in the X chromosome structure of four bovid species nilgai bull (Boselaphus tragocamelus), saola (Pseudoryx nghetinhensis), gaur (Bos gaurus), and Kirk’s Dikdik (Madoqua kirkii) were further analyzed using 26 cattle BAC-clones. We found the duplication on the X in saola. We show main rearrangements leading to the formation of four types of bovid X: Bovinae type with derived cattle subtype formed by centromere reposition and Antilopinae type with Caprini subtype formed by inversion in XSB1.

Published
2019

47. Evolution of gene regulation in ruminants differs between evolutionary breakpoint regions and homologous synteny blocks

Author

Farre Belmonte, M, Kim, J, Proskuryakova, A A, Zhang, Y, Kulemzina, A I, Li, Q, Xiong, Y, Johnson, J L, Perelman, P L, Johnson, W E, Warren, W, Kukekova, A V, Zhang, G, O'Brien, S J, Ryder, O A, Graphodatsky, A S, Ma, J, Lewin, H A, and Larkin, D M

Abstract

The role of chromosome rearrangements in driving evolution has been a long-standing question of evolutionary biology. Here we focused on ruminants as a model to assess how rearrangements may have contributed to the evolution of gene regulation. Using reconstructed ancestral karyotypes of Cetartiodactyls, Ruminants, Pecorans, and Bovids, we traced patterns of gross chromosome changes. We found that the lineage leading to the ruminant ancestor after the split from other cetartiodactyls was characterized by mostly intrachromosomal changes, whereas the lineage leading to the pecoran ancestor (including all livestock ruminants) included multiple interchromosomal changes. We observed that the liver cell putative enhancers in the ruminant evolutionary breakpoint regions are highly enriched for DNA sequences under selective constraint acting on lineage-specific transposable elements (TEs) and a set of 25 specific transcription factor (TF) binding motifs associated with recently active TEs. Coupled with gene expression data, we found that genes near ruminant breakpoint regions exhibit more divergent expression profiles among species, particularly in cattle, which is consistent with the phylogenetic origin of these breakpoint regions. This divergence was significantly greater in genes with enhancers that contain at least one of the 25 specific TF binding motifs and located near bovidae-to-cattle lineage breakpoint regions. Taken together, by combining ancestral karyotype reconstructions with analysis of cis regulatory element and gene expression evolution, our work demonstrated that lineage-specific regulatory elements colocalized with gross chromosome rearrangements may have provided valuable functional modifications that helped to shape ruminant evolution.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results