856 results on '"Nyegaard, Mette"'
Search Results
2. Homozygosity for a stop-gain variant in CCDC201 causes primary ovarian insufficiency
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Oddsson, Asmundur, Steinthorsdottir, Valgerdur, Oskarsson, Gudjon R., Styrkarsdottir, Unnur, Moore, Kristjan H. S., Isberg, Salvor, Halldorsson, Gisli H., Sveinbjornsson, Gardar, Westergaard, David, Nielsen, Henriette Svarre, Fridriksdottir, Run, Jensson, Brynjar O., Arnadottir, Gudny A., Jonsson, Hakon, Sturluson, Arni, Snaebjarnarson, Audunn S., Andreassen, Ole A., Walters, G. Bragi, Nyegaard, Mette, Erikstrup, Christian, Steingrimsdottir, Thora, Lie, Rolv T., Melsted, Pall, Jonsdottir, Ingileif, Halldorsson, Bjarni V., Thorleifsson, Gudmar, Saemundsdottir, Jona, Magnusson, Olafur Th., Banasik, Karina, Sorensen, Erik, Masson, Gisli, Pedersen, Ole Birger, Tryggvadottir, Laufey, Haavik, Jan, Ostrowski, Sisse Rye, Stefansson, Hreinn, Holm, Hilma, Rafnar, Thorunn, Gudbjartsson, Daniel F., Sulem, Patrick, and Stefansson, Kari
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- 2024
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3. Genome-wide association meta-analysis identifies five loci associated with postpartum hemorrhage
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Westergaard, David, Steinthorsdottir, Valgerdur, Stefansdottir, Lilja, Rohde, Palle Duun, Wu, Xiaoping, Geller, Frank, Tyrmi, Jaakko, Havulinna, Aki S., Solé-Navais, Pol, Flatley, Christopher, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Erikstrup, Christian, Sørensen, Erik, Mikkelsen, Christina, Bruun, Mie Topholm, Aagaard Jensen, Bitten, Brodersen, Thorsten, Ullum, Henrik, Magnus, Per, Andreassen, Ole A., Njolstad, Pål R., Kolte, Astrid Marie, Krebs, Lone, Nyegaard, Mette, Hansen, Thomas Folkmann, Feenstra, Bjarke, Daly, Mark, Lindgren, Cecilia M., Thorleifsson, Gudmar, Stefansson, Olafur A., Sveinbjornsson, Gardar, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Banasik, Karina, Jacobsson, Bo, Laisk, Triin, Laivuori, Hannele, Stefansson, Kari, Brunak, Søren, and Nielsen, Henriette Svarre
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- 2024
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4. Predicting the presence of coronary plaques featuring high-risk characteristics using polygenic risk scores and targeted proteomics in patients with suspected coronary artery disease
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Møller, Peter Loof, Rohde, Palle Duun, Dahl, Jonathan Nørtoft, Rasmussen, Laust Dupont, Nissen, Louise, Schmidt, Samuel Emil, McGilligan, Victoria, Gudbjartsson, Daniel F., Stefansson, Kari, Holm, Hilma, Bentzon, Jacob Fog, Bøttcher, Morten, Winther, Simon, and Nyegaard, Mette
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- 2024
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5. Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors
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Kjerulff, Bertram, Dowsett, Joseph, Jacobsen, Rikke Louise, Gladov, Josephine, Larsen, Margit Hørup, Lundgaard, Agnete Troen, Banasik, Karina, Westergaard, David, Mikkelsen, Susan, Dinh, Khoa Manh, Hindhede, Lotte, Kaspersen, Kathrine Agergård, Schwinn, Michael, Juul, Anders, Poulsen, Betina, Lindegaard, Birgitte, Pedersen, Carsten Bøcker, Sabel, Clive Eric, Bundgaard, Henning, Nielsen, Henriette Svarre, Møller, Janne Amstrup, Boldsen, Jens Kjærgaard, Burgdorf, Kristoffer Sølvsten, Kessing, Lars Vedel, Handgaard, Linda Jenny, Thørner, Lise Wegner, Didriksen, Maria, Nyegaard, Mette, Grarup, Niels, Ødum, Niels, Johansson, Pär I., Jennum, Poul, Frikke-Schmidt, Ruth, Berger, Sanne Schou, Brunak, Søren, Jacobsen, Søren, Hansen, Thomas Folkmann, Lundquist, Tine Kirkeskov, Hansen, Torben, Sørensen, Torben Lykke, Sigsgaard, Torben, Nielsen, Kaspar René, Bruun, Mie Topholm, Hjalgrim, Henrik, Ullum, Henrik, Rostgaard, Klaus, Sørensen, Erik, Pedersen, Ole Birger, Ostrowski, Sisse Rye, and Erikstrup, Christian
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- 2024
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6. A genome-wide association study of social trust in 33,882 Danish blood donors
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Sequeros, Celia Burgos, Hansen, Thomas Folkmann, Westergaard, David, Louloudis, Ioannis, Kalamajski, Sebastian, Röder, Timo, Rohde, Palle Duun, Schwinn, Michael, Clemmensen, Line Harder, Didriksen, Maria, Nyegaard, Mette, Hjalgrim, Henrik, Nielsen, Kaspar René, Bruun, Mie Topholm, Ostrowski, Sisse Rye, Erikstrup, Christian, Mikkelsen, Susan, Sørensen, Erik, Pedersen, Ole Birger Vestager, Brunak, Søren, Banasik, Karina, and Giordano, Giuseppe Nicola
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- 2024
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7. Variant in the synaptonemal complex protein SYCE2 associates with pregnancy loss through effect on recombination
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Steinthorsdottir, Valgerdur, Halldorsson, Bjarni V., Jonsson, Hakon, Palsson, Gunnar, Oddsson, Asmundur, Westergaard, David, Arnadottir, Gudny A., Stefansdottir, Lilja, Banasik, Karina, Esplin, M. Sean, Hansen, Thomas Folkmann, Brunak, Søren, Nyegaard, Mette, Ostrowski, Sisse Rye, Pedersen, Ole Birger Vesterager, Erikstrup, Christian, Thorleifsson, Gudmar, Nadauld, Lincoln D., Haraldsson, Asgeir, Steingrimsdottir, Thora, Tryggvadottir, Laufey, Jonsdottir, Ingileif, Gudbjartsson, Daniel F., Hoffmann, Eva R., Sulem, Patrick, Holm, Hilma, Nielsen, Henriette Svarre, and Stefansson, Kari
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- 2024
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8. Impact of CCR5Δ32 on the risk of infection, Staphylococcus aureus carriage, and plasma concentrations of chemokines in Danish blood donors
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Dinh, Khoa Manh, Kaspersen, Kathrine Agergård, Mikkelsen, Susan, Kjerulff, Bertram Dalskov, Boldsen, Jens Kjærgaard, Petersen, Mikkel Steen, Burgdorf, Kristoffer Sølvsten, Sørensen, Erik, Aagaard, Bitten, Forman-Ankjær, Barbara, Bruun, Mie Topholm, Banasik, Karina, Hansen, Thomas Folkmann, Nyegaard, Mette, Rohde, Palle Duun, Brunak, Søren, Hjalgrim, Henrik, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Ullum, Henrik, Erikstrup, Lise Tornvig, and Erikstrup, Christian
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- 2024
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9. Biomarkers for identification of high-risk coronary artery plaques in patients with suspected coronary artery disease
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Pedersen, Gitte, Dahl, Jonathan Nørtoft, Rasmussen, Laust Dupont, Garm Blavnsfeldt, Anne-Birgitte, Böttcher, Sidsel Hauge, Böttcher, Matias Hauge, Nyegaard, Mette, Nissen, Louise, and Winther, Simon
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- 2024
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10. Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
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Beaumont, Robin N., Flatley, Christopher, Vaudel, Marc, Wu, Xiaoping, Chen, Jing, Moen, Gunn-Helen, Skotte, Line, Helgeland, Øyvind, Solé-Navais, Pol, Banasik, Karina, Albiñana, Clara, Ronkainen, Justiina, Fadista, João, Stinson, Sara Elizabeth, Trajanoska, Katerina, Wang, Carol A., Westergaard, David, Srinivasan, Sundararajan, Sánchez-Soriano, Carlos, Bilbao, Jose Ramon, Allard, Catherine, Groleau, Marika, Kuulasmaa, Teemu, Leirer, Daniel J., White, Frédérique, Jacques, Pierre-Étienne, Cheng, Haoxiang, Hao, Ke, Andreassen, Ole A., Åsvold, Bjørn Olav, Atalay, Mustafa, Bhatta, Laxmi, Bouchard, Luigi, Brumpton, Ben Michael, Brunak, Søren, Bybjerg-Grauholm, Jonas, Ebbing, Cathrine, Elliott, Paul, Engelbrechtsen, Line, Erikstrup, Christian, Estarlich, Marisa, Franks, Stephen, Gaillard, Romy, Geller, Frank, Grove, Jakob, Hougaard, David M., Kajantie, Eero, Morgen, Camilla S., Nohr, Ellen A., Nyegaard, Mette, Palmer, Colin N. A., Pedersen, Ole Birger, Rivadeneira, Fernando, Sebert, Sylvain, Shields, Beverley M., Stoltenberg, Camilla, Surakka, Ida, Thørner, Lise Wegner, Ullum, Henrik, Vaarasmaki, Marja, Vilhjalmsson, Bjarni J., Willer, Cristen J., Lakka, Timo A., Gybel-Brask, Dorte, Bustamante, Mariona, Hansen, Torben, Pearson, Ewan R., Reynolds, Rebecca M., Ostrowski, Sisse R., Pennell, Craig E., Jaddoe, Vincent W. V., Felix, Janine F., Hattersley, Andrew T., Melbye, Mads, Lawlor, Deborah A., Hveem, Kristian, Werge, Thomas, Nielsen, Henriette Svarre, Magnus, Per, Evans, David M., Jacobsson, Bo, Järvelin, Marjo-Riitta, Zhang, Ge, Hivert, Marie-France, Johansson, Stefan, Freathy, Rachel M., Feenstra, Bjarke, and Njølstad, Pål R.
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- 2023
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11. Dual intron-targeted CRISPR-Cas9-mediated disruption of the AML RUNX1-RUNX1T1 fusion gene effectively inhibits proliferation and decreases tumor volume in vitro and in vivo
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Neldeborg, Signe, Soerensen, Johannes Frasez, Møller, Charlotte Thornild, Bill, Marie, Gao, Zongliang, Bak, Rasmus O., Holm, Kasper, Sorensen, Boe, Nyegaard, Mette, Luo, Yonglun, Hokland, Peter, Stougaard, Magnus, Ludvigsen, Maja, and Holm, Christian Kanstrup
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- 2023
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12. Myocardial Blood Flow by Magnetic Resonance in Patients With Suspected Coronary Stenosis: Comparison to PET and Invasive Physiology
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Rasmussen, Laust Dupont, Murphy, Theodore, Milidonis, Xenios, Eftekhari, Ashkan, Karim, Salma Raghad, Westra, Jelmer, Dahl, Jonathan Nørtoft, Isaksen, Christin, Brix, Lau, Ejlersen, June Anita, Nyegaard, Mette, Johansen, Jane Kirk, Søndergaard, Hanne Maare, Mortensen, Jesper, Gormsen, Lars Christian, Christiansen, Evald Høj, Chiribiri, Amedeo, Petersen, Steffen E., Bøttcher, Morten, and Winther, Simon
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- 2024
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13. Developmental language disorder – heritability and genetic correlations with other disorders affecting language
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Banasik, Karina, Bay, Jakob, Kjærgaard Boldsen, Jens, Brodersen, Thorsten, Brunak, Søren, Demur, Alfonso Buil, Nordahl Christoffersen, Lea Arregui, Didriksen, Maria, Dinh, Khoa Manh, Dowsett, Joseph, Erikstrup, Christian, Feenstra, Bjarke, Geller, Frank, Gudbjartsson, Daniel, Hansen, Thomas Folkmann, Mikkelsen, Dorte Helenius, Hindhede, Lotte, Hjalgrim, Henrik, von Stemann, Jakob Hjorth, Jensen, Bitten Aagaard, Schork, Andrew Joseph, Kaspersen, Kathrine, Kjerulff, Bertram Dalskov, Kongstad, Mette, Mikkelsen, Susan, Mikkelsen, Christina, Nissen, Janna, Nyegaard, Mette, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Elgaard Quinn, Liam James, Rafnar, Þórunn, Rohde, Palle Duun, Rostgaard, Klaus, Schwinn, Michael, Sørensen, Erik, Stefansson, Kari, Stefánsson, Hreinn, Thørner, Lise Wegner, Þorsteinsdóttir, Unnur, Bruun, Mie Topholm, Ullum, Henrik, Werge, Thomas, Westergaard, David, Nudel, Ron, Chrsitensen, Rikke Vang, Kalnak, Nelli, Lundberg, Mischa, Christoffersen, Lea Arregui Nordahl, Burgdorf, Kristoffer Sølvsten, Pedersen, Ole Birger Vesterager, Gísladóttir, Rósa S., and Walters, G. Bragi
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- 2024
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14. Calcium Scoring Improves Clinical Management in Patients With Low Clinical Likelihood of Coronary Artery Disease
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Brix, Gitte S., Rasmussen, Laust D., Rohde, Palle D., Schmidt, Samuel E., Nyegaard, Mette, Douglas, Pamela S., Newby, David E., Williams, Michelle C., Foldyna, Borek, Knuuti, Juhani, Bøttcher, Morten, and Winther, Simon
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- 2024
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15. Publisher Correction: Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality
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Oddsson, Asmundur, Sulem, Patrick, Sveinbjornsson, Gardar, Arnadottir, Gudny A., Steinthorsdottir, Valgerdur, Halldorsson, Gisli H., Atlason, Bjarni A., Oskarsson, Gudjon R., Helgason, Hannes, Nielsen, Henriette Svarre, Westergaard, David, Karjalainen, Juha M., Katrinardottir, Hildigunnur, Fridriksdottir, Run, Jensson, Brynjar O., Tragante, Vinicius, Ferkingstad, Egil, Jonsson, Hakon, Gudjonsson, Sigurjon A., Beyter, Doruk, Moore, Kristjan H. S., Thordardottir, Helga B., Kristmundsdottir, Snaedis, Stefansson, Olafur A., Rantapää-Dahlqvist, Solbritt, Sonderby, Ida Elken, Didriksen, Maria, Stridh, Pernilla, Haavik, Jan, Tryggvadottir, Laufey, Frei, Oleksandr, Walters, G. Bragi, Kockum, Ingrid, Hjalgrim, Henrik, Olafsdottir, Thorunn A., Selbaek, Geir, Nyegaard, Mette, Erikstrup, Christian, Brodersen, Thorsten, Saevarsdottir, Saedis, Olsson, Tomas, Nielsen, Kaspar Rene, Haraldsson, Asgeir, Bruun, Mie Topholm, Hansen, Thomas Folkmann, Steingrimsdottir, Thora, Jacobsen, Rikke Louise, Lie, Rolv T., Djurovic, Srdjan, Alfredsson, Lars, Lopez de Lapuente Portilla, Aitzkoa, Brunak, Soren, Melsted, Pall, Halldorsson, Bjarni V., Saemundsdottir, Jona, Magnusson, Olafur Th., Padyukov, Leonid, Banasik, Karina, Rafnar, Thorunn, Askling, Johan, Klareskog, Lars, Pedersen, Ole Birger, Masson, Gisli, Havdahl, Alexandra, Nilsson, Bjorn, Andreassen, Ole A., Daly, Mark, Ostrowski, Sisse Rye, Jonsdottir, Ingileif, Stefansson, Hreinn, Holm, Hilma, Helgason, Agnar, Thorsteinsdottir, Unnur, Stefansson, Kari, and Gudbjartsson, Daniel F.
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- 2023
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16. Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality
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Oddsson, Asmundur, Sulem, Patrick, Sveinbjornsson, Gardar, Arnadottir, Gudny A., Steinthorsdottir, Valgerdur, Halldorsson, Gisli H., Atlason, Bjarni A., Oskarsson, Gudjon R., Helgason, Hannes, Nielsen, Henriette Svarre, Westergaard, David, Karjalainen, Juha M., Katrinardottir, Hildigunnur, Fridriksdottir, Run, Jensson, Brynjar O., Tragante, Vinicius, Ferkingstad, Egil, Jonsson, Hakon, Gudjonsson, Sigurjon A., Beyter, Doruk, Moore, Kristjan H. S., Thordardottir, Helga B., Kristmundsdottir, Snaedis, Stefansson, Olafur A., Rantapää-Dahlqvist, Solbritt, Sonderby, Ida Elken, Didriksen, Maria, Stridh, Pernilla, Haavik, Jan, Tryggvadottir, Laufey, Frei, Oleksandr, Walters, G. Bragi, Kockum, Ingrid, Hjalgrim, Henrik, Olafsdottir, Thorunn A., Selbaek, Geir, Nyegaard, Mette, Erikstrup, Christian, Brodersen, Thorsten, Saevarsdottir, Saedis, Olsson, Tomas, Nielsen, Kaspar Rene, Haraldsson, Asgeir, Bruun, Mie Topholm, Hansen, Thomas Folkmann, Steingrimsdottir, Thora, Jacobsen, Rikke Louise, Lie, Rolv T., Djurovic, Srdjan, Alfredsson, Lars, Lopez de Lapuente Portilla, Aitzkoa, Brunak, Soren, Melsted, Pall, Halldorsson, Bjarni V., Saemundsdottir, Jona, Magnusson, Olafur Th., Padyukov, Leonid, Banasik, Karina, Rafnar, Thorunn, Askling, Johan, Klareskog, Lars, Pedersen, Ole Birger, Masson, Gisli, Havdahl, Alexandra, Nilsson, Bjorn, Andreassen, Ole A., Daly, Mark, Ostrowski, Sisse Rye, Jonsdottir, Ingileif, Stefansson, Hreinn, Holm, Hilma, Helgason, Agnar, Thorsteinsdottir, Unnur, Stefansson, Kari, and Gudbjartsson, Daniel F.
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- 2023
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17. DanMAC5: a browser of aggregated sequence variants from 8,671 whole genome sequenced Danish individuals
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Banasik, Karina, Møller, Peter L., Techlo, Tanya R., Holm, Peter C., Walters, G. Bragi, Ingason, Andrés, Rosengren, Anders, Rohde, Palle D., Kogelman, Lisette J. A., Westergaard, David, Siggaard, Troels, Chmura, Piotr J., Chalmer, Mona A., Magnússon, Ólafur Þ., Þórisson, Guðmundur Á., Stefánsson, Hreinn, Guðbjartsson, Daníel F., Stefánsson, Kári, Olesen, Jes, Winther, Simon, Bøttcher, Morten, Brunak, Søren, Werge, Thomas, Nyegaard, Mette, and Hansen, Thomas F.
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- 2023
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18. Genetic effects on the timing of parturition and links to fetal birth weight
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Solé-Navais, Pol, Flatley, Christopher, Steinthorsdottir, Valgerdur, Vaudel, Marc, Juodakis, Julius, Chen, Jing, Laisk, Triin, LaBella, Abigail L., Westergaard, David, Bacelis, Jonas, Brumpton, Ben, Skotte, Line, Borges, Maria C., Helgeland, Øyvind, Mahajan, Anubha, Wielscher, Matthias, Lin, Frederick, Briggs, Catherine, Wang, Carol A., Moen, Gunn-Helen, Beaumont, Robin N., Bradfield, Jonathan P., Abraham, Abin, Thorleifsson, Gudmar, Gabrielsen, Maiken E., Ostrowski, Sisse R., Modzelewska, Dominika, Nohr, Ellen A., Hypponen, Elina, Srivastava, Amit, Talbot, Octavious, Allard, Catherine, Williams, Scott M., Menon, Ramkumar, Shields, Beverley M., Sveinbjornsson, Gardar, Xu, Huan, Melbye, Mads, Lowe, Jr, William, Bouchard, Luigi, Oken, Emily, Pedersen, Ole B., Gudbjartsson, Daniel F., Erikstrup, Christian, Sørensen, Erik, Lie, Rolv T., Teramo, Kari, Hallman, Mikko, Juliusdottir, Thorhildur, Hakonarson, Hakon, Ullum, Henrik, Hattersley, Andrew T., Sletner, Line, Merialdi, Mario, Rifas-Shiman, Sheryl L., Steingrimsdottir, Thora, Scholtens, Denise, Power, Christine, West, Jane, Nyegaard, Mette, Capra, John A., Skogholt, Anne H., Magnus, Per, Andreassen, Ole A., Thorsteinsdottir, Unnur, Grant, Struan F. A., Qvigstad, Elisabeth, Pennell, Craig E., Hivert, Marie-France, Hayes, Geoffrey M., Jarvelin, Marjo-Riitta, McCarthy, Mark I., Lawlor, Deborah A., Nielsen, Henriette S., Mägi, Reedik, Rokas, Antonis, Hveem, Kristian, Stefansson, Kari, Feenstra, Bjarke, Njolstad, Pål, Muglia, Louis J., Freathy, Rachel M., Johansson, Stefan, Zhang, Ge, and Jacobsson, Bo
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- 2023
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19. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
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Rahmioglu, Nilufer, Mortlock, Sally, Ghiasi, Marzieh, Møller, Peter L., Stefansdottir, Lilja, Galarneau, Geneviève, Turman, Constance, Danning, Rebecca, Law, Matthew H., Sapkota, Yadav, Christofidou, Paraskevi, Skarp, Sini, Giri, Ayush, Banasik, Karina, Krassowski, Michal, Lepamets, Maarja, Marciniak, Błażej, Nõukas, Margit, Perro, Danielle, Sliz, Eeva, Sobalska-Kwapis, Marta, Thorleifsson, Gudmar, Topbas-Selcuki, Nura F., Vitonis, Allison, Westergaard, David, Arnadottir, Ragnheidur, Burgdorf, Kristoffer S., Campbell, Archie, Cheuk, Cecilia S. K., Clementi, Caterina, Cook, James, De Vivo, Immaculata, DiVasta, Amy, Dorien, O., Donoghue, Jacqueline F., Edwards, Todd, Fontanillas, Pierre, Fung, Jenny N., Geirsson, Reynir T., Girling, Jane E., Harkki, Paivi, Harris, Holly R., Healey, Martin, Heikinheimo, Oskari, Holdsworth-Carson, Sarah, Hostettler, Isabel C., Houlden, Henry, Houshdaran, Sahar, Irwin, Juan C., Jarvelin, Marjo-Riitta, Kamatani, Yoichiro, Kennedy, Stephen H., Kepka, Ewa, Kettunen, Johannes, Kubo, Michiaki, Kulig, Bartosz, Kurra, Venla, Laivuori, Hannele, Laufer, Marc R., Lindgren, Cecilia M., MacGregor, Stuart, Mangino, Massimo, Martin, Nicholas G., Matalliotaki, Charoula, Matalliotakis, Michail, Murray, Alison D., Ndungu, Anne, Nezhat, Camran, Olsen, Catherine M., Opoku-Anane, Jessica, Padmanabhan, Sandosh, Paranjpe, Manish, Peters, Maire, Polak, Grzegorz, Porteous, David J., Rabban, Joseph, Rexrode, Kathyrn M., Romanowicz, Hanna, Saare, Merli, Saavalainen, Liisu, Schork, Andrew J., Sen, Sushmita, Shafrir, Amy L., Siewierska-Górska, Anna, Słomka, Marcin, Smith, Blair H., Smolarz, Beata, Szaflik, Tomasz, Szyłło, Krzysztof, Takahashi, Atsushi, Terry, Kathryn L., Tomassetti, Carla, Treloar, Susan A., Vanhie, Arne, Vincent, Katy, Vo, Kim C., Werring, David J., Zeggini, Eleftheria, Zervou, Maria I., Adachi, Sosuke, Buring, Julie E., Ridker, Paul M., D’Hooghe, Thomas, Goulielmos, George N., Hapangama, Dharani K., Hayward, Caroline, Horne, Andrew W., Low, Siew-Kee, Martikainen, Hannu, Chasman, Daniel I., Rogers, Peter A. W., Saunders, Philippa T., Sirota, Marina, Spector, Tim, Strapagiel, Dominik, Tung, Joyce Y., Whiteman, David C., Giudice, Linda C., Velez-Edwards, Digna R., Uimari, Outi, Kraft, Peter, Salumets, Andres, Nyholt, Dale R., Mägi, Reedik, Stefansson, Kari, Becker, Christian M., Yurttas-Beim, Piraye, Steinthorsdottir, Valgerdur, Nyegaard, Mette, Missmer, Stacey A., Montgomery, Grant W., Morris, Andrew P., and Zondervan, Krina T.
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- 2023
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20. Complex effects of sequence variants on lipid levels and coronary artery disease
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Snaebjarnarson, Audunn S., Helgadottir, Anna, Arnadottir, Gudny A., Ivarsdottir, Erna V., Thorleifsson, Gudmar, Ferkingstad, Egil, Einarsson, Gudmundur, Sveinbjornsson, Gardar, Thorgeirsson, Thorgeir E., Ulfarsson, Magnus O., Halldorsson, Bjarni V., Olafsson, Isleifur, Erikstrup, Christian, Pedersen, Ole B., Nyegaard, Mette, Bruun, Mie T., Ullum, Henrik, Brunak, Søren, Iversen, Kasper Karmark, Christensen, Alex Hoerby, Olesen, Morten S., Ghouse, Jonas, Banasik, Karina, Knowlton, Kirk U., Arnar, David O., Thorgeirsson, Gudmundur, Nadauld, Lincoln, Ostrowski, Sisse Rye, Bundgaard, Henning, Holm, Hilma, Sulem, Patrick, Stefansson, Kari, and Gudbjartsson, Daniel F.
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- 2023
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21. Seminal Plasma-Derived Extracellular-Vesicle Fractions from HIV-Infected Men Exhibit Unique MicroRNA Signatures and Induce a Proinflammatory Response in Cells Isolated from the Female Reproductive Tract
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de Menezes, Erika G Marques, Jang, Karen, George, Ashley F, Nyegaard, Mette, Neidleman, Jason, Inglis, Heather C, Danesh, Ali, Deng, Xutao, Afshari, Amirali, Kim, Young H, Billaud, Jean-Noël, Marson, Kara, Pilcher, Christopher D, Pillai, Satish K, Norris, Philip J, and Roan, Nadia R
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Medical Microbiology ,Biomedical and Clinical Sciences ,Immunology ,Clinical Research ,Biotechnology ,Prevention ,Infectious Diseases ,HIV/AIDS ,Genetics ,Sexually Transmitted Infections ,2.1 Biological and endogenous factors ,Infection ,Good Health and Well Being ,Adult ,Cohort Studies ,Cytokines ,Extracellular Vesicles ,Female ,Genitalia ,Female ,HIV Infections ,HIV-1 ,Humans ,Male ,MicroRNAs ,Semen ,Sexual Behavior ,Transcriptome ,extracellular vesicles ,epithelial cells ,female reproductive tract ,human immunodeficiency virus ,miRNAs ,seminal plasma ,stromal fibroblasts ,transcription ,Biological Sciences ,Agricultural and Veterinary Sciences ,Medical and Health Sciences ,Virology ,Agricultural ,veterinary and food sciences ,Biological sciences ,Biomedical and clinical sciences - Abstract
The continuing spread of HIV/AIDS is predominantly fueled by sexual exposure to HIV-contaminated semen. Seminal plasma (SP), the liquid portion of semen, harbors a variety of factors that may favor HIV transmission by facilitating viral entry into host cells, eliciting the production of proinflammatory cytokines, and enhancing the translocation of HIV across the genital epithelium. One important and abundant class of factors in SP is extracellular vesicles (EVs), which, in general, are important intercellular signal transducers. Although numerous studies have characterized blood plasma-derived EVs from both uninfected and HIV-infected individuals, little is known about the properties of EVs from the semen of HIV-infected individuals. We report here that fractionated SP enriched for EVs from HIV-infected men induces potent transcriptional responses in epithelial and stromal cells that interface with the luminal contents of the female reproductive tract. Semen EV fractions from acutely infected individuals induced a more proinflammatory signature than those from uninfected individuals. This was not associated with any observable differences in the surface phenotypes of the vesicles. However, microRNA (miRNA) expression profiling analysis revealed that EV fractions from infected individuals exhibit a broader and more diverse profile than those from uninfected individuals. Taken together, our data suggest that SP EVs from HIV-infected individuals exhibit unique miRNA signatures and exert potent proinflammatory transcriptional changes in cells of the female reproductive tract, which may facilitate HIV transmission.IMPORTANCE Seminal plasma (SP), the major vehicle for HIV, can modulate HIV transmission risk through a variety of mechanisms. Extracellular vesicles (EVs) are extremely abundant in semen, and because they play a key role in intercellular communication pathways and immune regulation, they may impact the likelihood of HIV transmission. However, little is known about the properties and signaling effects of SP-derived EVs in the context of HIV transmission. Here, we conduct a phenotypic, transcriptomic, and functional characterization of SP and SP-derived EVs from uninfected and HIV-infected men. We find that both SP and its associated EVs elicit potent proinflammatory transcriptional responses in cells that line the genital tract. EVs from HIV-infected men exhibit a more diverse repertoire of miRNAs than EVs from uninfected men. Our findings suggest that EVs from the semen of HIV-infected men may significantly impact the likelihood of HIV transmission through multiple mechanisms.
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- 2020
22. Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits
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Zhou, Hang, Sealock, Julia M, Sanchez-Roige, Sandra, Clarke, Toni-Kim, Levey, Daniel F, Cheng, Zhongshan, Li, Boyang, Polimanti, Renato, Kember, Rachel L, Smith, Rachel Vickers, Thygesen, Johan H, Morgan, Marsha Y, Atkinson, Stephen R, Thursz, Mark R, Nyegaard, Mette, Mattheisen, Manuel, Børglum, Anders D, Johnson, Emma C, Justice, Amy C, Palmer, Abraham A, McQuillin, Andrew, Davis, Lea K, Edenberg, Howard J, Agrawal, Arpana, Kranzler, Henry R, and Gelernter, Joel
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Biological Psychology ,Psychology ,Genetics ,Alcoholism ,Alcohol Use and Health ,Substance Misuse ,Brain Disorders ,Human Genome ,Aetiology ,2.1 Biological and endogenous factors ,Cardiovascular ,Mental health ,Good Health and Well Being ,Alcohol Drinking ,Alcoholism ,Datasets as Topic ,Female ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Male ,Multifactorial Inheritance ,Neurosciences ,Cognitive Sciences ,Neurology & Neurosurgery ,Biological psychology - Abstract
Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. Although genome-wide association studies have identified PAU risk genes, the genetic architecture of this trait is not fully understood. We conducted a proxy-phenotype meta-analysis of PAU, combining alcohol use disorder and problematic drinking, in 435,563 European-ancestry individuals. We identified 29 independent risk variants, 19 of them novel. PAU was genetically correlated with 138 phenotypes, including substance use and psychiatric traits. Phenome-wide polygenic risk score analysis in an independent biobank sample (BioVU, n = 67,589) confirmed the genetic correlations between PAU and substance use and psychiatric disorders. Genetic heritability of PAU was enriched in brain and in conserved and regulatory genomic regions. Mendelian randomization suggested causal effects on liability to PAU of substance use, psychiatric status, risk-taking behavior and cognitive performance. In summary, this large PAU meta-analysis identified novel risk loci and revealed genetic relationships with numerous other traits.
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- 2020
23. Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling.
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George, Ashley F, Jang, Karen S, Nyegaard, Mette, Neidleman, Jason, Spitzer, Trimble L, Xie, Guorui, Chen, Joseph C, Herzig, Eytan, Laustsen, Anders, Marques de Menezes, Erika G, Houshdaran, Sahar, Pilcher, Christopher D, Norris, Philip J, Jakobsen, Martin R, Greene, Warner C, Giudice, Linda C, and Roan, Nadia R
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Contraception/Reproduction ,Clinical Research ,2.1 Biological and endogenous factors ,Aetiology ,Reproductive health and childbirth ,Cross-Sectional Studies ,Decidua ,Endometriosis ,Endometrium ,Female ,Fibroblasts ,Humans ,Interleukin-11 ,Polycystic Ovary Syndrome ,Semen ,reproduction ,semen ,endometrium ,stromal fibroblast ,decidualization ,RNAseq ,interleukin-II ,extracellular vesicles ,CRISPR ,Cas-9 ,CRISPR/Cas-9 ,interleukin-11 ,Medical and Health Sciences ,Studies in Human Society ,Obstetrics & Reproductive Medicine - Abstract
Study questionDo seminal plasma (SP) and its constituents affect the decidualization capacity and transcriptome of human primary endometrial stromal fibroblasts (eSFs)?Summary answerSP promotes decidualization of eSFs from women with and without inflammatory disorders (polycystic ovary syndrome (PCOS), endometriosis) in a manner that is not mediated through semen amyloids and that is associated with a potent transcriptional response, including the induction of interleukin (IL)-11, a cytokine important for SP-induced decidualization.What is known alreadyClinical studies have suggested that SP can promote implantation, and studies in vitro have demonstrated that SP can promote decidualization, a steroid hormone-driven program of eSF differentiation that is essential for embryo implantation and that is compromised in women with the inflammatory disorders PCOS and endometriosis.Study design, size, durationThis is a cross-sectional study involving samples treated with vehicle alone versus treatment with SP or SP constituents. SP was tested for the ability to promote decidualization in vitro in eSFs from women with or without PCOS or endometriosis (n = 9). The role of semen amyloids and fractionated SP in mediating this effect and in eliciting transcriptional changes in eSFs was then studied. Finally, the role of IL-11, a cytokine with a key role in implantation and decidualization, was assessed as a mediator of the SP-facilitated decidualization.Participants/materials, setting, methodseSFs and endometrial epithelial cells (eECs) were isolated from endometrial biopsies from women of reproductive age undergoing benign gynecologic procedures and maintained in vitro. Assays were conducted to assess whether the treatment of eSFs with SP or SP constituents affects the rate and extent of decidualization in women with and without inflammatory disorders. To characterize the response of the endometrium to SP and SP constituents, RNA was isolated from treated eSFs or eECs and analyzed by RNA sequencing (RNAseq). Secreted factors in conditioned media from treated cells were analyzed by Luminex and ELISA. The role of IL-11 in SP-induced decidualization was assessed through Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas-9-mediated knockout experiments in primary eSFs.Main results and the role of chanceSP promoted decidualization both in the absence and presence of steroid hormones (P
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- 2020
24. Endometriosis is associated with pregnancy loss: a nationwide historical cohort study
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Boje, Amalie Dyhrberg, Egerup, Pia, Westergaard, David, Bertelsen, Marie-Louise Mathilde Friis, Nyegaard, Mette, Hartwell, Dorthe, Lidegaard, Øjvind, and Nielsen, Henriette Svarre
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- 2023
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25. Second-Line Myocardial Perfusion Imaging to Detect Obstructive Stenosis: Head-to-Head Comparison of CMR and PET
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Rasmussen, Laust Dupont, Winther, Simon, Eftekhari, Ashkan, Karim, Salma Raghad, Westra, Jelmer, Isaksen, Christin, Brix, Lau, Ejlersen, June Anita, Murphy, Theodore, Milidonis, Xenios, Nyegaard, Mette, Benovoy, Mitchel, Johansen, Jane Kirk, Søndergaard, Hanne Maare, Hammid, Osama, Mortensen, Jesper, Knudsen, Lars Lyhne, Gormsen, Lars Christian, Christiansen, Evald Høj, Chiribiri, Amedeo, Petersen, Steffen E., and Böttcher, Morten
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- 2023
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26. Cell-free fetal DNA for genetic evaluation in Copenhagen Pregnancy Loss Study (COPL): a prospective cohort study
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Nielsen, Henriette Svarre, Hartwig, Tanja Schlaikjær, Freiesleben, Nina la Cour, Jørgensen, Finn Stener Jørgensen, Ambye, Louise, Bliddal, Sofie, Søndergaard, Therese Juhlin, Ostrowski, Sisse Rye, Sørensen, Erik, Larsen, Margit Anita Hørup, Herregård, Markus J., Hoffmann, Eva, Gruhn, Jenny, Chan, Andy Chi Ho, Kolte, Astrid Marie, Westergaard, David, þorsteinsdóttir, Unnur, Stefánsson, Kári, Jónsson, Hákon, Magnússon, Ólafur þ., Steinthorsdottir, Valgerdur, Schmidt, Lone, Kristiansen, Karsten, Kamstrup, Pia Rørbæk, Nyegaard, Mette, Krog, Maria Christine, Løkkegaard, Ellen Christine Leth, Bredkjær, Helle Ejdrup, Wilken-Jensen, Charlotte, Schlaikjær Hartwig, Tanja, Gruhn, Jennifer R, Petersen, Jesper Friis, Wrønding, Tine, Amato, Letizia, Chi-Ho Chan, Andrew, Ji, Boyang, Bro-Jørgensen, Maiken Hemme, Werge, Lene, Petersen, Mette Marie Babiel Schmidt, Brinkmann, Clara, Ribberholt, Julie Boesgaard, Dunø, Morten, Bache, Iben, Herrgård, Markus J, Jørgensen, Finn Stener, and Hoffmann, Eva R
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- 2023
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27. Association between socioeconomic position and coronary artery calcium score in patients with symptoms suggestive of obstructive coronary artery disease
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Nissen, Louise, Winding, Trine Nøhr, Schmidt, Samuel Emil, Hasan Shafi, Bilal, Bossano Prescott, Eva Irene, Nyegaard, Mette, Winther, Simon, and Bøttcher, Morten
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- 2023
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28. Identification of common genetic risk variants for autism spectrum disorder
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Grove, Jakob, Ripke, Stephan, Als, Thomas D, Mattheisen, Manuel, Walters, Raymond K, Won, Hyejung, Pallesen, Jonatan, Agerbo, Esben, Andreassen, Ole A, Anney, Richard, Awashti, Swapnil, Belliveau, Rich, Bettella, Francesco, Buxbaum, Joseph D, Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Cerrato, Felecia, Chambert, Kimberly, Christensen, Jane H, Churchhouse, Claire, Dellenvall, Karin, Demontis, Ditte, De Rubeis, Silvia, Devlin, Bernie, Djurovic, Srdjan, Dumont, Ashley L, Goldstein, Jacqueline I, Hansen, Christine S, Hauberg, Mads Engel, Hollegaard, Mads V, Hope, Sigrun, Howrigan, Daniel P, Huang, Hailiang, Hultman, Christina M, Klei, Lambertus, Maller, Julian, Martin, Joanna, Martin, Alicia R, Moran, Jennifer L, Nyegaard, Mette, Nærland, Terje, Palmer, Duncan S, Palotie, Aarno, Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, dPoterba, Timothy, Poulsen, Jesper Buchhave, Pourcain, Beate St, Qvist, Per, Rehnström, Karola, Reichenberg, Abraham, Reichert, Jennifer, Robinson, Elise B, Roeder, Kathryn, Roussos, Panos, Saemundsen, Evald, Sandin, Sven, Satterstrom, F Kyle, Davey Smith, George, Stefansson, Hreinn, Steinberg, Stacy, Stevens, Christine R, Sullivan, Patrick F, Turley, Patrick, Walters, G Bragi, Xu, Xinyi, Stefansson, Kari, Geschwind, Daniel H, Nordentoft, Merete, Hougaard, David M, Werge, Thomas, Mors, Ole, Mortensen, Preben Bo, Neale, Benjamin M, Daly, Mark J, and Børglum, Anders D
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Intellectual and Developmental Disabilities (IDD) ,Human Genome ,Pediatric ,Brain Disorders ,Autism ,Biotechnology ,Genetics ,Mental Health ,Prevention ,2.3 Psychological ,social and economic factors ,Aetiology ,2.1 Biological and endogenous factors ,Mental health ,Adolescent ,Autism Spectrum Disorder ,Case-Control Studies ,Child ,Child ,Preschool ,Denmark ,Female ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Male ,Multifactorial Inheritance ,Phenotype ,Polymorphism ,Single Nucleotide ,Risk Factors ,Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium ,BUPGEN ,Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium ,23andMe Research Team ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology - Abstract
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no individual variants have been robustly associated with ASD. With a marked sample-size increase from a unique Danish population resource, we report a genome-wide association meta-analysis of 18,381 individuals with ASD and 27,969 controls that identified five genome-wide-significant loci. Leveraging GWAS results from three phenotypes with significantly overlapping genetic architectures (schizophrenia, major depression, and educational attainment), we identified seven additional loci shared with other traits at equally strict significance levels. Dissecting the polygenic architecture, we found both quantitative and qualitative polygenic heterogeneity across ASD subtypes. These results highlight biological insights, particularly relating to neuronal function and corticogenesis, and establish that GWAS performed at scale will be much more productive in the near term in ASD.
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- 2019
29. Author Correction: Genetic effects on the timing of parturition and links to fetal birth weight
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Solé-Navais, Pol, Flatley, Christopher, Steinthorsdottir, Valgerdur, Vaudel, Marc, Juodakis, Julius, Chen, Jing, Laisk, Triin, LaBella, Abigail L., Westergaard, David, Bacelis, Jonas, Brumpton, Ben, Skotte, Line, Borges, Maria C., Helgeland, Øyvind, Mahajan, Anubha, Wielscher, Matthias, Lin, Frederick, Briggs, Catherine, Wang, Carol A., Moen, Gunn-Helen, Beaumont, Robin N., Bradfield, Jonathan P., Abraham, Abin, Thorleifsson, Gudmar, Gabrielsen, Maiken E., Ostrowski, Sisse R., Modzelewska, Dominika, Nohr, Ellen A., Hypponen, Elina, Srivastava, Amit, Talbot, Octavious, Allard, Catherine, Williams, Scott M., Menon, Ramkumar, Shields, Beverley M., Sveinbjornsson, Gardar, Xu, Huan, Melbye, Mads, Lowe, Jr, William, Bouchard, Luigi, Oken, Emily, Pedersen, Ole B., Gudbjartsson, Daniel F., Erikstrup, Christian, Sørensen, Erik, Lie, Rolv T., Teramo, Kari, Hallman, Mikko, Juliusdottir, Thorhildur, Hakonarson, Hakon, Ullum, Henrik, Hattersley, Andrew T., Sletner, Line, Merialdi, Mario, Rifas-Shiman, Sheryl L., Steingrimsdottir, Thora, Scholtens, Denise, Power, Christine, West, Jane, Nyegaard, Mette, Capra, John A., Skogholt, Anne H., Magnus, Per, Andreassen, Ole A., Thorsteinsdottir, Unnur, Grant, Struan F. A., Qvigstad, Elisabeth, Pennell, Craig E., Hivert, Marie-France, Hayes, Geoffrey M., Jarvelin, Marjo-Riitta, McCarthy, Mark I., Lawlor, Deborah A., Nielsen, Henriette S., Mägi, Reedik, Rokas, Antonis, Hveem, Kristian, Stefansson, Kari, Feenstra, Bjarke, Njolstad, Pål, Muglia, Louis J., Freathy, Rachel M., Johansson, Stefan, Zhang, Ge, and Jacobsson, Bo
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- 2023
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30. Calmodulin variants in schizophrenia patients display gain-of-function or loss-of-function effects
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Jensen, Helene Halkjær, primary, Brohus, Malene, additional, Hussey, John W., additional, Busuioc, Ana-Octavia, additional, Iversen, Emil Drivsholm, additional, Darki, Faezeh, additional, Nikolova, Gabriela Dobromirova, additional, Baisgaard, Amalie Elton, additional, Rohde, Palle Duun, additional, Holm, Ida Elisabeth Gad, additional, McQuillin, Andrew, additional, Moos, Torben, additional, Dick, Ivy E., additional, Overgaard, Michael Toft, additional, and Nyegaard, Mette, additional
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- 2024
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31. Pregnancy loss in women with endocrine disorders - a nationwide registry-based cohort study of 366,548 Danish women
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Egerup, Pia, primary, Bliddal, Sofie, additional, Westergaard, David, additional, Glintborg, Dorte, additional, Bonnema, Steen J., additional, Feldt-Rasmussen, Ulla, additional, Nyegaard, Mette, additional, Mortensen, Laust Hvas, additional, and Svarre, Nielsen Henriette, additional
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- 2024
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32. Calmodulin, sudden death, and the Folbigg case: genes in court
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Schwartz, Peter J, primary, Crotti, Lia, additional, Nyegaard, Mette, additional, and Overgaard, Michael Toft, additional
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- 2024
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33. Idiopathic early ovarian aging: is there a relation with premenopausal accelerated biological aging in young women with diminished response to ART?
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Christensen, Mette W., Keefe, David L., Wang, Fang, Hansen, Christine S., Chamani, Isaac J., Sommer, Carolyn, Nyegaard, Mette, Rohde, Palle D., Nielsen, Anders L., Bybjerg-Grauholm, Jonas, Kesmodel, Ulrik S., Knudsen, Ulla B., Kirkegaard, Kirstine, and Ingerslev, Hans Jakob
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- 2021
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34. Polygenic risk scores in coronary artery disease
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Christiansen, Morten Krogh, Nyegaard, Mette, and Jensen, Henrik Kjærulf
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- 2023
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35. Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry.
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Sapkota, Yadav, Vivo, Immaculata De, Steinthorsdottir, Valgerdur, Fassbender, Amelie, Bowdler, Lisa, Buring, Julie E, Edwards, Todd L, Jones, Sarah, O, Dorien, Peterse, Daniëlle, Rexrode, Kathryn M, Ridker, Paul M, Schork, Andrew J, Thorleifsson, Gudmar, Wallace, Leanne M, iPSYCH-SSI-Broad Group, Kraft, Peter, Morris, Andrew P, Nyholt, Dale R, Edwards, Digna R Velez, Nyegaard, Mette, D'Hooghe, Thomas, Chasman, Daniel I, Stefansson, Kari, Missmer, Stacey A, and Montgomery, Grant W
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iPSYCH-SSI-Broad Group ,Humans ,Endometriosis ,Genetic Predisposition to Disease ,Case-Control Studies ,Chromosome Mapping ,Polymorphism ,Single Nucleotide ,European Continental Ancestry Group ,Female ,Meta-Analysis as Topic ,Genetic Variation ,Genome-Wide Association Study ,Exome ,Biomarkers ,Whole Exome Sequencing ,Genetics ,Human Genome ,Clinical Research ,2.1 Biological and endogenous factors - Abstract
Genome-wide association (GWA) studies have identified 19 independent common risk loci for endometriosis. Most of the GWA variants are non-coding and the genes responsible for the association signals have not been identified. Herein, we aimed to assess the potential role of protein-modifying variants in endometriosis using exome-array genotyping in 7164 cases and 21005 controls, and a replication set of 1840 cases and 129016 controls of European ancestry. Results in the discovery sample identified significant evidence for association with coding variants in single-variant (rs1801232-CUBN) and gene-level (CIITA and PARP4) meta-analyses, but these did not survive replication. In the combined analysis, there was genome-wide significant evidence for rs13394619 (P = 2.3 × 10-9) in GREB1 at 2p25.1 - a locus previously identified in a GWA meta-analysis of European and Japanese samples. Despite sufficient power, our results did not identify any protein-modifying variants (MAF > 0.01) with moderate or large effect sizes in endometriosis, although these variants may exist in non-European populations or in high-risk families. The results suggest continued discovery efforts should focus on genotyping large numbers of surgically-confirmed endometriosis cases and controls, and/or sequencing high-risk families to identify novel rare variants to provide greater insights into the molecular pathogenesis of the disease.
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- 2017
36. Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.
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Sapkota, Yadav, Steinthorsdottir, Valgerdur, Morris, Andrew P, Fassbender, Amelie, Rahmioglu, Nilufer, De Vivo, Immaculata, Buring, Julie E, Zhang, Futao, Edwards, Todd L, Jones, Sarah, O, Dorien, Peterse, Daniëlle, Rexrode, Kathryn M, Ridker, Paul M, Schork, Andrew J, MacGregor, Stuart, Martin, Nicholas G, Becker, Christian M, Adachi, Sosuke, Yoshihara, Kosuke, Enomoto, Takayuki, Takahashi, Atsushi, Kamatani, Yoichiro, Matsuda, Koichi, Kubo, Michiaki, Thorleifsson, Gudmar, Geirsson, Reynir T, Thorsteinsdottir, Unnur, Wallace, Leanne M, iPSYCH-SSI-Broad Group, Yang, Jian, Velez Edwards, Digna R, Nyegaard, Mette, Low, Siew-Kee, Zondervan, Krina T, Missmer, Stacey A, D'Hooghe, Thomas, Montgomery, Grant W, Chasman, Daniel I, Stefansson, Kari, Tung, Joyce Y, and Nyholt, Dale R
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iPSYCH-SSI-Broad Group ,Humans ,Endometriosis ,Genetic Predisposition to Disease ,Gonadal Steroid Hormones ,Estrogen Receptor alpha ,Genotype ,Polymorphism ,Single Nucleotide ,Adult ,Aged ,Middle Aged ,Female ,Metabolic Networks and Pathways ,Genome-Wide Association Study ,Genetic Loci ,Genetics ,Pain Research ,Human Genome ,Contraception/Reproduction ,Clinical Research ,Prevention ,2.1 Biological and endogenous factors ,1.1 Normal biological development and functioning - Abstract
Endometriosis is a heritable hormone-dependent gynecological disorder, associated with severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely unknown. Here we perform a meta-analysis of 11 genome-wide association case-control data sets, totalling 17,045 endometriosis cases and 191,596 controls. In addition to replicating previously reported loci, we identify five novel loci significantly associated with endometriosis risk (P
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- 2017
37. Homozygosity for a stop-gain variant in CCDC201causes primary ovarian insufficiency
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Oddsson, Asmundur, Steinthorsdottir, Valgerdur, Oskarsson, Gudjon R., Styrkarsdottir, Unnur, Moore, Kristjan H. S., Isberg, Salvor, Halldorsson, Gisli H., Sveinbjornsson, Gardar, Westergaard, David, Nielsen, Henriette Svarre, Fridriksdottir, Run, Jensson, Brynjar O., Arnadottir, Gudny A., Jonsson, Hakon, Sturluson, Arni, Snaebjarnarson, Audunn S., Andreassen, Ole A., Walters, G. Bragi, Nyegaard, Mette, Erikstrup, Christian, Steingrimsdottir, Thora, Lie, Rolv T., Melsted, Pall, Jonsdottir, Ingileif, Halldorsson, Bjarni V., Thorleifsson, Gudmar, Saemundsdottir, Jona, Magnusson, Olafur Th., Banasik, Karina, Sorensen, Erik, Masson, Gisli, Pedersen, Ole Birger, Tryggvadottir, Laufey, Haavik, Jan, Ostrowski, Sisse Rye, Stefansson, Hreinn, Holm, Hilma, Rafnar, Thorunn, Gudbjartsson, Daniel F., Sulem, Patrick, and Stefansson, Kari
- Abstract
Age at menopause (AOM) has a substantial impact on fertility and disease risk. While many loci with variants that associate with AOM have been identified through genome-wide association studies (GWAS) under an additive model, other genetic models are rarely considered1. Here through GWAS meta-analysis under the recessive model of 174,329 postmenopausal women from Iceland, Denmark, the United Kingdom (UK; UK Biobank) and Norway, we study low-frequency variants with a large effect on AOM. We discovered that women homozygous for the stop-gain variant rs117316434(A) in CCDC201(p.(Arg162Ter), minor allele frequency ~1%) reached menopause 9 years earlier than other women (P= 1.3 × 10−15). The genotype is present in one in 10,000 northern European women and leads to primary ovarian insufficiency in close to half of them. Consequently, homozygotes have fewer children, and the age at last childbirth is 5 years earlier (P= 3.8 × 10−5). The CCDC201gene was only found in humans in 2022 and is highly expressed in oocytes. Homozygosity for CCDC201loss-of-function has a substantial impact on female reproductive health, and homozygotes would benefit from reproductive counseling and treatment for symptoms of early menopause.
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- 2024
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38. Blood donation and migraine relief:A national population cohort study in Denmark
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Davidsson, Olafur B., Rostgaard, Klaus, Chalmer, Mona A., Kogelman, Lisette J.A., Aagaard, Bitten, Brodersen, Thorsten, Bruun, Mie Topholm, Mikkelsen, Christina, Mikkelsen, Susan, Nyegaard, Mette, Pedersen, Ole Birger, Ullum, Henrik, Sørensen, Erik, Ostrowski, Sisse Rye, Erikstrup, Christian, Hansen, Thomas Folkmann, Hjalgrim, Henrik, Davidsson, Olafur B., Rostgaard, Klaus, Chalmer, Mona A., Kogelman, Lisette J.A., Aagaard, Bitten, Brodersen, Thorsten, Bruun, Mie Topholm, Mikkelsen, Christina, Mikkelsen, Susan, Nyegaard, Mette, Pedersen, Ole Birger, Ullum, Henrik, Sørensen, Erik, Ostrowski, Sisse Rye, Erikstrup, Christian, Hansen, Thomas Folkmann, and Hjalgrim, Henrik
- Abstract
Introduction Migraine is a prevalent neurological headache disorder. Due to challenges associated with finding effective treatment, many individuals with migraine feel compelled to explore alternative treatment strategies, such as blood donation, hypothesized to provide migraine relief. Methods Through logistic, Poisson, and Cox regression methods, we examined the links between migraine and blood donation activities in two population cohorts: Danish blood donors in the Scandinavian Donations and Transfusions Database (SCANDAT-DK, N >1 million) and the Danish Blood Donor Study (N ~ 100,000). Results SCANDAT-DK analyses showed no link between migraine and the propensity to become a blood donor among males (odds ratio [OR]Males = 0.95 [95% Confidence Interval: 0.86–1.04], and a reduced propensity among females ORFemales = 0.88 [0.83–0.93]). The incidence of migraine was not reduced upon blood donation (standardized incidence ratio [SIR]Males = 0.94 [0.83–1.06]; SIRFemales = 1.04 [0.99–1.10]). Donors with migraine demonstrated longer intervals between donations (hazard ratio [HR]Males = 0.87 [0.85–0.91], HRFemales = 0.80 [0.78–0.82]), and an increased risk of donor lapse (ORMales = 1.23 [1.14–1.32]; ORFemales = 1.28 [1.22–1.33]). Results were corroborated in DBDS using self-reported migraine. Genetic predisposition to migraine associated with longer intervals in females (HRFemales = 0.98 [0.97–0.99]), but not in males. Discussion Our findings do not support the hypothesis that blood donation serves as a viable treatment strategy among migraine patients. Future prospective investigations may help to elucidate the underlying biological mechanisms by which blood donation may influence migraine pathology., Introduction: Migraine is a prevalent neurological headache disorder. Due to challenges associated with finding effective treatment, many individuals with migraine feel compelled to explore alternative treatment strategies, such as blood donation, hypothesized to provide migraine relief. Methods: Through logistic, Poisson, and Cox regression methods, we examined the links between migraine and blood donation activities in two population cohorts: Danish blood donors in the Scandinavian Donations and Transfusions Database (SCANDAT-DK, N >1 million) and the Danish Blood Donor Study (N ~ 100,000). Results: SCANDAT-DK analyses showed no link between migraine and the propensity to become a blood donor among males (odds ratio [OR]Males = 0.95 [95% Confidence Interval: 0.86–1.04], and a reduced propensity among females ORFemales = 0.88 [0.83–0.93]). The incidence of migraine was not reduced upon blood donation (standardized incidence ratio [SIR]Males = 0.94 [0.83–1.06]; SIRFemales = 1.04 [0.99–1.10]). Donors with migraine demonstrated longer intervals between donations (hazard ratio [HR]Males = 0.87 [0.85–0.91], HRFemales = 0.80 [0.78–0.82]), and an increased risk of donor lapse (ORMales = 1.23 [1.14–1.32]; ORFemales = 1.28 [1.22–1.33]). Results were corroborated in DBDS using self-reported migraine. Genetic predisposition to migraine associated with longer intervals in females (HRFemales = 0.98 [0.97–0.99]), but not in males. Discussion: Our findings do not support the hypothesis that blood donation serves as a viable treatment strategy among migraine patients. Future prospective investigations may help to elucidate the underlying biological mechanisms by which blood donation may influence migraine pathology.
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- 2024
39. Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer’s disease
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Monti, Giulia, Kjolby, Mads, Jensen, Anne Mette G., Allen, Mariet, Reiche, Juliane, Møller, Peter L., Comaposada-Baró, Raquel, Zolkowski, Bartlomiej E., Vieira, Cármen, Jørgensen, Margarita Melnikova, Holm, Ida E., Valdmanis, Paul N., Wellner, Niels, Vægter, Christian B., Lincoln, Sarah J., Nykjær, Anders, Ertekin-Taner, Nilüfer, Young, Jessica E., Nyegaard, Mette, and Andersen, Olav M.
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- 2021
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40. Therapeutic endometrial scratching and implantation after in vitro fertilization: a multicenter randomized controlled trial
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Olesen, Mia Steengaard, Hauge, Benedicte, Ohrt, Lisbeth, Olesen, Tine Nørregaard, Roskær, Janne, Bæk, Vibeke, Elbæk, Helle Olesen, Nøhr, Bugge, Nyegaard, Mette, Overgaard, Michael Toft, Humaidan, Peter, Forman, Axel, and Agerholm, Inge
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- 2019
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41. Familial analysis reveals rare risk variants for migraine in regulatory regions
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Techlo, Tanya Ramdal, Rasmussen, Andreas Høiberg, Møller, Peter L., Bøttcher, Morten, Winther, Simon, Davidsson, Olafur B., Olofsson, Isa A., Chalmer, Mona Ameri, Kogelman, Lisette J. A., Nyegaard, Mette, Olesen, Jes, and Hansen, Thomas Folkmann
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- 2020
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42. SMIM1 absence is associated with reduced energy expenditure and excess weight
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Banasik, Karina, Bay, Jakob, Boldsen, Jens Kjærgaard, Brodersen, Thorsten, Brunak, Søren, Burgdorf, Kristoffer, Chalmer, Mona Ameri, Didriksen, Maria, Dinh, Khoa Manh, Dowsett, Joseph, Erikstrup, Christian, Feenstra, Bjarke, Geller, Frank, Gudbjartsson, Daniel, Hansen, Thomas Folkmann, Hindhede, Lotte, Hjalgrim, Henrik, Jacobsen, Rikke Louise, Jemec, Gregor, Jensen, Bitten Aagaard, Kaspersen, Katrine, Kjerulff, Bertram Dalskov, Kogelman, Lisette, Hørup Larsen, Margit Anita, Louloudis, Ioannis, Lundgaard, Agnete, Susan, Mikkelsen, Christina, Nissen, Ioanna, Nyegaard, Mette, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Henriksen, Alexander Pil, Rohde, Palle Duun, Rostgaard, Klaus, Schwinn, Michael, Stefansson, Kari, Stefánsson, Hreinn, Sørensen, Erik, þorsteinsdóttir, Unnur, Thørner, Lise Wegner, Bruun, Mie Topholm, Ullum, Henrik, Werge, Thomas, Westergaard, David, Chen, Ji, Spracklen, Cassandra N., Marenne, Gaëlle, Varshney, Arushi, Corbin, Laura J., Luan, Jian’an, Willems, Sara M., Wu, Ying, Zhang, Xiaoshuai, Horikoshi, Momoko, Boutin, Thibaud S., Mägi, Reedik, Waage, Johannes, Li-Gao, Ruifang, Katie Chan, Kei Hang, Yao, Jie, Anasanti, Mila D., Chu, Audrey Y., Claringbould, Annique, Heikkinen, Jani, Hong, Jaeyoung, Hottenga, Jouke-Jan, Huo, Shaofeng, Kaakinen, Marika A., Louie, Tin, März, Winfried, Moreno-Macias, Hortensia, Ndungu, Anne, Nelson, Sarah C., Nolte, Ilja M., North, Kari E., Raulerson, Chelsea K., Ray, Debashree, Rohde, Rebecca, Rybin, Denis, Schurmann, Claudia, Sim, Xueling, Southam, Loz, Stewart, Isobel D., Wang, Carol A., Wang, Yujie, Wu, Peitao, Zhang, Weihua, Ahluwalia, Tarunveer S., Appel, Emil V.R., Bielak, Lawrence F., Brody, Jennifer A., Burtt, Noël P., Cabrera, Claudia P., Cade, Brian E., Chai, Jin Fang, Chai, Xiaoran, Chang, Li-Ching, Chen, Chien-Hsiun, Chen, Brian H., Chitrala, Kumaraswamy Naidu, Chiu, Yen-Feng, de Haan, Hugoline G., Delgado, Graciela E., Demirkan, Ayse, Duan, Qing, Engmann, Jorgen, Fatumo, Segun A., Gayán, Javier, Giulianini, Franco, Gong, Jung Ho, Gustafsson, Stefan, Hai, Yang, Hartwig, Fernando P., He, Jing, Heianza, Yoriko, Huang, Tao, Huerta-Chagoya, Alicia, Hwang, Mi Yeong, Jensen, Richard A., Kawaguchi, Takahisa, Kentistou, Katherine A., Kim, Young Jin, Kleber, Marcus E., Kooner, Ishminder K., Lai, Shuiqing, Lange, Leslie A., Langefeld, Carl D., Lauzon, Marie, Li, Man, Ligthart, Symen, Liu, Jun, Loh, Marie, Long, Jirong, Lyssenko, Valeriya, Mangino, Massimo, Marzi, Carola, Montasser, May E., Nag, Abhishek, Nakatochi, Masahiro, Noce, Damia, Noordam, Raymond, Pistis, Giorgio, Preuss, Michael, Raffield, Laura, Rasmussen-Torvik, Laura J., Rich, Stephen S., Robertson, Neil R., Rueedi, Rico, Ryan, Kathleen, Sanna, Serena, Saxena, Richa, Schraut, Katharina E., Sennblad, Bengt, Setoh, Kazuya, Smith, Albert V., Southam, Lorraine, Sparsø, Thomas, Strawbridge, Rona J., Takeuchi, Fumihiko, Tan, Jingyi, Trompet, Stella, van den Akker, Erik, van der Most, Peter J., Verweij, Niek, Vogel, Mandy, Wang, Heming, Wang, Chaolong, Wang, Nan, Warren, Helen R., Wen, Wanqing, Wilsgaard, Tom, Wong, Andrew, Wood, Andrew R., Xie, Tian, Zafarmand, Mohammad Hadi, Zhao, Jing-Hua, Zhao, Wei, Amin, Najaf, Arzumanyan, Zorayr, Astrup, Arne, Bakker, Stephan J.L., Baldassarre, Damiano, Beekman, Marian, Bergman, Richard N., Bertoni, Alain, Blüher, Matthias, Bonnycastle, Lori L., Bornstein, Stefan R., Bowden, Donald W., Cai, Qiuyin, Campbell, Archie, Campbell, Harry, Chang, Yi Cheng, de Geus, Eco J.C., Dehghan, Abbas, Du, Shufa, Eiriksdottir, Gudny, Farmaki, Aliki Eleni, Frånberg, Mattias, Fuchsberger, Christian, Gao, Yutang, Gjesing, Anette P., Goel, Anuj, Han, Sohee, Hartman, Catharina A., Herder, Christian, Hicks, Andrew A., Hsieh, Chang-Hsun, Hsueh, Willa A., Ichihara, Sahoko, Igase, Michiya, Ikram, M. Arfan, Johnson, W. Craig, Jørgensen, Marit E., Joshi, Peter K., Kalyani, Rita R., Kandeel, Fouad R., Katsuya, Tomohiro, Khor, Chiea Chuen, Kiess, Wieland, Kolcic, Ivana, Kuulasmaa, Teemu, Kuusisto, Johanna, Läll, Kristi, Lam, Kelvin, Lawlor, Deborah A., Lee, Nanette R., Lemaitre, Rozenn N., Li, Honglan, Lin, Shih-Yi, Lindström, Jaana, Linneberg, Allan, Liu, Jianjun, Lorenzo, Carlos, Matsubara, Tatsuaki, Matsuda, Fumihiko, Mingrone, Geltrude, Mooijaart, Simon, Moon, Sanghoon, Nabika, Toru, Nadkarni, Girish N., Nadler, Jerry L., Nelis, Mari, Neville, Matt J., Norris, Jill M., Ohyagi, Yasumasa, Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Qi, Qibin, Raven, Dennis, Reilly, Dermot F., Reiner, Alex, Rivideneira, Fernando, Roll, Kathryn, Rudan, Igor, Sabanayagam, Charumathi, Sandow, Kevin, Sattar, Naveed, Schürmann, Annette, Shi, Jinxiu, Stringham, Heather M., Taylor, Kent D., Teslovich, Tanya M., Thuesen, Betina, Timmers, Paul R.H.J., Tremoli, Elena, Tsai, Michael Y., Uitterlinden, Andre, van Dam, Rob M., van Heemst, Diana, van Hylckama Vlieg, Astrid, Van Vliet-Ostaptchouk, Jana V., Vangipurapu, Jagadish, Vestergaard, Henrik, Wang, Tao, Willems van Dijk, Ko, Zemunik, Tatijana, Abecasis, Goncalo R., Adair, Linda S., Aguilar-Salinas, Carlos Alberto, Alarcón-Riquelme, Marta E., An, Ping, Aviles-Santa, Larissa, Becker, Diane M., Beilin, Lawrence J., Bergmann, Sven, Bisgaard, Hans, Black, Corri, Boehnke, Michael, Boerwinkle, Eric, Böhm, Bernhard O., Bønnelykke, Klaus, Boomsma, D.I., Bottinger, Erwin P., Buchanan, Thomas A., Canouil, Mickaël, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Ida Chen, Yii-Der, Cheng, Ching-Yu, Collins, Francis S., Correa, Adolfo, Cucca, Francesco, Janaka de Silva, H., Dedoussis, George, Elmståhl, Sölve, Evans, Michele K., Ferrannini, Ele, Ferrucci, Luigi, Florez, Jose C., Franks, Paul W., Frayling, Timothy M., Froguel, Philippe, Gigante, Bruna, Goodarzi, Mark O., Gordon-Larsen, Penny, Grallert, Harald, Grarup, Niels, Grimsgaard, Sameline, Groop, Leif, Gudnason, Vilmundur, Guo, Xiuqing, Hamsten, Anders, Hansen, Torben, Hayward, Caroline, Heckbert, Susan R., Horta, Bernardo L., Huang, Wei, Ingelsson, Erik, James, Pankow S., Jarvelin, Marjo-Ritta, Jonas, Jost B., Jukema, J. Wouter, Kaleebu, Pontiano, Kaplan, Robert, Kardia, Sharon L.R., Kato, Norihiro, Keinanen-Kiukaanniemi, Sirkka M., Kim, Bong-Jo, Kivimaki, Mika, Koistinen, Heikki A., Kooner, Jaspal S., Körner, Antje, Kovacs, Peter, Kuh, Diana, Kumari, Meena, Kutalik, Zoltan, Laakso, Markku, Lakka, Timo A., Launer, Lenore J., Leander, Karin, Li, Huaixing, Lin, Xu, Lind, Lars, Lindgren, Cecilia, Liu, Simin, Loos, Ruth J.F., Magnusson, Patrik K.E., Mahajan, Anubha, Metspalu, Andres, Mook-Kanamori, Dennis O., Mori, Trevor A., Munroe, Patricia B., Njølstad, Inger, O'Connell, Jeffrey R., Oldehinkel, Albertine J., Ong, Ken K., Padmanabhan, Sandosh, Palmer, Colin N.A., Palmer, Nicholette D., Pedersen, Oluf, Pennell, Craig E., Porteous, David J., Pramstaller, Peter P., Province, Michael A., Psaty, Bruce M., Qi, Lu, Raffel, Leslie J., Rauramaa, Rainer, Redline, Susan, Ridker, Paul M., Rosendaal, Frits R., Saaristo, Timo E., Sandhu, Manjinder, Saramies, Jouko, Schneiderman, Neil, Schwarz, Peter, Scott, Laura J., Selvin, Elizabeth, Sever, Peter, Shu, Xiao-Ou, Slagboom, P. Eline, Small, Kerrin S., Smith, Blair H., Snieder, Harold, Sofer, Tamar, Sørensen, Thorkild I.A., Spector, Tim D., Stanton, Alice, Steves, Claire J., Stumvoll, Michael, Sun, Liang, Tabara, Yasuharu, Tai, E. Shyong, Timpson, Nicholas J., Tönjes, Anke, Tuomilehto, Jaakko, Tusie, Teresa, Uusitupa, Matti, van der Harst, Pim, van Duijn, Cornelia, Vitart, Veronique, Vollenweider, Peter, Vrijkotte, Tanja G.M., Wagenknecht, Lynne E., Walker, Mark, Wang, Ya X., Wareham, Nick J., Watanabe, Richard M., Watkins, Hugh, Wei, Wen B., Wickremasinghe, Ananda R., Willemsen, Gonneke, Wilson, James F., Wong, Tien-Yin, Wu, Jer-Yuarn, Xiang, Anny H., Yanek, Lisa R., Yengo, Loïc, Yokota, Mitsuhiro, Zeggini, Eleftheria, Zheng, Wei, Zonderman, Alan B., Rotter, Jerome I., Gloyn, Anna L., McCarthy, Mark I., Dupuis, Josée, Meigs, James B., Scott, Robert A., Prokopenko, Inga, Leong, Aaron, Liu, Ching-Ti, Parker, Stephen C.J., Mohlke, Karen L., Langenberg, Claudia, Wheeler, Eleanor, Morris, Andrew P., Barroso, Inês, Stefanucci, Luca, Moslemi, Camous, Tomé, Ana R., Virtue, Samuel, Bidault, Guillaume, Gleadall, Nicholas S., Watson, Laura P.E., Kwa, Jing E., Burden, Frances, Farrow, Samantha, Võsa, Urmo, Burling, Keith, Walker, Lindsay, Ord, John, Barker, Peter, Warner, James, Frary, Amy, Renhstrom, Karola, Ashford, Sofie E., Piper, Jo, Biggs, Gail, Erber, Wendy N., Hoffman, Gary J., Schoenmakers, Nadia, Rieneck, Klaus, Dziegiel, Morten H., Azzu, Vian, Vacca, Michele, Aparicio, Hugo Javier, Hui, Qin, Cho, Kelly, Sun, Yan V., Wilson, Peter W., Bayraktar, Omer A., Vidal-Puig, Antonio, Ostrowski, Sisse R., Astle, William J., Olsson, Martin L., Storry, Jill R., Pedersen, Ole B., Ouwehand, Willem H., Chatterjee, Krishna, Vuckovic, Dragana, and Frontini, Mattia
- Published
- 2024
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43. Blood donation and migraine relief: A national population cohort study in Denmark.
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Davidsson, Olafur B., Rostgaard, Klaus, Chalmer, Mona A., Kogelman, Lisette J. A., Aagaard, Bitten, Brodersen, Thorsten, Bruun, Mie Topholm, Mikkelsen, Christina, Mikkelsen, Susan, Nyegaard, Mette, Pedersen, Ole Birger, Ullum, Henrik, Sørensen, Erik, Ostrowski, Sisse Rye, Erikstrup, Christian, Hansen, Thomas Folkmann, and Hjalgrim, Henrik
- Subjects
MIGRAINE ,COHORT analysis ,BLOOD donors ,ODDS ratio ,NEUROLOGICAL disorders - Abstract
Introduction: Migraine is a prevalent neurological headache disorder. Due to challenges associated with finding effective treatment, many individuals with migraine feel compelled to explore alternative treatment strategies, such as blood donation, hypothesized to provide migraine relief. Methods: Through logistic, Poisson, and Cox regression methods, we examined the links between migraine and blood donation activities in two population cohorts: Danish blood donors in the Scandinavian Donations and Transfusions Database (SCANDAT‐DK, N >1 million) and the Danish Blood Donor Study (N ~ 100,000). Results: SCANDAT‐DK analyses showed no link between migraine and the propensity to become a blood donor among males (odds ratio [OR]Males = 0.95 [95% Confidence Interval: 0.86–1.04], and a reduced propensity among females ORFemales = 0.88 [0.83–0.93]). The incidence of migraine was not reduced upon blood donation (standardized incidence ratio [SIR]Males = 0.94 [0.83–1.06]; SIRFemales = 1.04 [0.99–1.10]). Donors with migraine demonstrated longer intervals between donations (hazard ratio [HR]Males = 0.87 [0.85–0.91], HRFemales = 0.80 [0.78–0.82]), and an increased risk of donor lapse (ORMales = 1.23 [1.14–1.32]; ORFemales = 1.28 [1.22–1.33]). Results were corroborated in DBDS using self‐reported migraine. Genetic predisposition to migraine associated with longer intervals in females (HRFemales = 0.98 [0.97–0.99]), but not in males. Discussion: Our findings do not support the hypothesis that blood donation serves as a viable treatment strategy among migraine patients. Future prospective investigations may help to elucidate the underlying biological mechanisms by which blood donation may influence migraine pathology. [ABSTRACT FROM AUTHOR]
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- 2024
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44. Genetic Underpinnings of Social Trust: Insights from 33,882 Danish Blood Donors
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Banasik, Karina, primary, Sequeros, Celia Burgos, additional, Hansen, Thomas, additional, Westergaard, David, additional, Louloudis, Ioannis, additional, Kalamajski, Sebastian, additional, Röder, Timo, additional, Rohde, Palle Duun, additional, Schwinn, Michael, additional, Clemmensen, Line Harder, additional, Didriksen, Maria, additional, Nyegaard, Mette, additional, Hjalgrim, Henrik, additional, Nielsen, Kaspar, additional, Bruun, Mie Topholm, additional, Ostrowski, Sisse, additional, Erikstrup, Christian, additional, Mikkelsen, Susan, additional, Sørensen, Erik, additional, Pedersen, Ole, additional, Brunak, Søren, additional, and Giordano, Giuseppe, additional
- Published
- 2023
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45. Combining Polygenic and Proteomic Risk Scores With Clinical Risk Factors to Improve Performance for Diagnosing Absence of Coronary Artery Disease in Patients With De Novo Chest Pain
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Møller, Peter Loof, primary, Rohde, Palle Duun, additional, Dahl, Jonathan Nørtoft, additional, Rasmussen, Laust Dupont, additional, Schmidt, Samuel Emil, additional, Nissen, Louise, additional, McGilligan, Victoria, additional, Bentzon, Jacob F., additional, Gudbjartsson, Daniel F., additional, Stefansson, Kari, additional, Holm, Hilma, additional, Winther, Simon, additional, Bøttcher, Morten, additional, and Nyegaard, Mette, additional
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- 2023
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46. Biomarkers for Identification of High-Risk Coronary Artery Plaques in Patients with Suspected Coronary Artery Disease
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Pedersen, Gitte, primary, Dahl, Jonathan Nørtoft, additional, Rasmussen, Laust Dupont, additional, Blavnsfeldt, Anne-Birgitte Garm, additional, Bøttcher, Sidsel Hauge, additional, Bøttcher, Matias Hauge, additional, Nyegaard, Mette, additional, Nissen, Louise, additional, and Winther, Simon, additional
- Published
- 2023
- Full Text
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47. Genome-wide association study implicates CHRNA2 in cannabis use disorder
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Demontis, Ditte, Rajagopal, Veera Manikandan, Thorgeirsson, Thorgeir E., Als, Thomas D., Grove, Jakob, Leppälä, Kalle, Gudbjartsson, Daniel F., Pallesen, Jonatan, Hjorthøj, Carsten, Reginsson, Gunnar W., Tyrfingsson, Thorarinn, Runarsdottir, Valgerdur, Qvist, Per, Christensen, Jane Hvarregaard, Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Huckins, Laura M., Stahl, Eli A., Timmermann, Allan, Agerbo, Esben, Hougaard, David M., Werge, Thomas, Mors, Ole, Mortensen, Preben Bo, Nordentoft, Merete, Daly, Mark J., Stefansson, Hreinn, Stefansson, Kari, Nyegaard, Mette, and Børglum, Anders D.
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- 2019
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48. Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice
- Author
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Rajkumar, Anto P., Qvist, Per, Donskov, Julie G., Lazarus, Ross, Pallesen, Jonatan, Nava, Nicoletta, Winther, Gudrun, Liebenberg, Nico, Cour, Sanne H. la, Paternoster, Veerle, Fryland, Tue, Palmfeldt, Johan, Fejgin, Kim, Mørk, Arne, Nyegaard, Mette, Pakkenberg, Bente, Didriksen, Michael, Nyengaard, Jens R., Wegener, Gregers, Mors, Ole, Christensen, Jane H., and Børglum, Anders D.
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- 2020
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49. Calmodulin mutations affecting Gly114 impair binding to the NaV1.5 IQ-domain
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Brohus, Malene, primary, Busuioc, Ana-Octavia, additional, Wimmer, Reinhard, additional, Nyegaard, Mette, additional, and Overgaard, Michael Toft, additional
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- 2023
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50. Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry
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Crotti, Lia, primary, Spazzolini, Carla, additional, Nyegaard, Mette, additional, Overgaard, Michael T, additional, Kotta, Maria-Christina, additional, Dagradi, Federica, additional, Sala, Luca, additional, Aiba, Takeshi, additional, Ayers, Mark D, additional, Baban, Anwar, additional, Barc, Julien, additional, Beach, Cheyenne M, additional, Behr, Elijah R, additional, Bos, J Martijn, additional, Cerrone, Marina, additional, Covi, Peter, additional, Cuneo, Bettina, additional, Denjoy, Isabelle, additional, Donner, Birgit, additional, Elbert, Adrienne, additional, Eliasson, Håkan, additional, Etheridge, Susan P, additional, Fukuyama, Megumi, additional, Girolami, Francesca, additional, Hamilton, Robert, additional, Horie, Minoru, additional, Iascone, Maria, additional, Jaimez, Juan Jiménez, additional, Jensen, Henrik Kjærulf, additional, Kannankeril, Prince J, additional, Kaski, Juan P, additional, Makita, Naomasa, additional, Muñoz-Esparza, Carmen, additional, Odland, Hans H, additional, Ohno, Seiko, additional, Papagiannis, John, additional, Porretta, Alessandra Pia, additional, Prandstetter, Christopher, additional, Probst, Vincent, additional, Robyns, Tomas, additional, Rosenthal, Eric, additional, Rosés-Noguer, Ferran, additional, Sekarski, Nicole, additional, Singh, Anoop, additional, Spentzou, Georgia, additional, Stute, Fridrike, additional, Tfelt-Hansen, Jacob, additional, Till, Jan, additional, Tobert, Kathryn E, additional, Vinocur, Jeffrey M, additional, Webster, Gregory, additional, Wilde, Arthur A M, additional, Wolf, Cordula M, additional, Ackerman, Michael J, additional, and Schwartz, Peter J, additional
- Published
- 2023
- Full Text
- View/download PDF
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