1. Association between iron deficiency anemia and severe maternal morbidity: A retrospective cohort study.
- Author
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Nyarko SH, Greenberg LT, Saade GR, Phibbs CS, Buzas JS, Lorch SA, Rogowski J, Passarella M, and Boghossian NS
- Subjects
- Humans, Female, Retrospective Studies, Pregnancy, Adult, Young Adult, Risk Factors, Pregnancy Complications, Hematologic epidemiology, Postpartum Period, Morbidity, United States epidemiology, Anemia, Iron-Deficiency epidemiology, Blood Transfusion statistics & numerical data
- Abstract
Purpose: We examined the association between iron deficiency anemia (IDA) and severe maternal morbidity (SMM) during delivery and up to 1-year postpartum., Methods: In a retrospective cohort study across 3 states, we computed adjusted relative risks (aRR) for SMM comparing individuals with IDA versus those without, using modified Poisson regression models., Results: Among 2459,106 individuals, 10.3 % (n = 252,240) had IDA. Individuals with IDA experienced higher rates of blood transfusion and non-transfusion SMM (329 and 122 per 10,000 deliveries, respectively) than those without IDA (33 and 46 per 10,000 deliveries, respectively). The risk of blood transfusion (aRR: 8.2; 95 % CI 7.9-8.5) and non-transfusion SMM (aRR: 1.9; 95 % CI: 1.8-2.0) were higher among individuals with IDA. The attributable risk per 10,000 deliveries due to IDA for blood transfusion and non-transfusion SMM during delivery were 29.5 (95 % CI: 28.9-30.0) and 5.7 (95 % CI: 5.3-6.2), respectively. Within 1-year postpartum, the relative risk of non-transfusion SMM (aRR:1.3; 95 % CI: 1.2-1.3) was 30 % higher among individuals with IDA., Conclusion: IDA is associated with increased SMM risk. Addressing IDA in pregnant individuals may reduce SMM rates., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Nansi Boghossian reports financial support was provided by National Institute on Minority Health and Health Disparities. Samuel Nyarko reports financial support was provided by National Institute on Minority Health and Health Disparities. Lucy Greenberg reports financial support was provided by National Institute on Minority Health and Health Disparities. Molly Passarella reports financial support was provided by National Institute on Minority Health and Health Disparities. Scott Lorch reports financial support was provided by National Institute on Minority Health and Health Disparities. Ciaran Phibbs reports financial support was provided by National Institute on Minority Health and Health Disparities. George Saade reports financial support was provided by National Institute on Minority Health and Health Disparities. Jeff Buzas reports financial support was provided by National Institute on Minority Health and Health Disparities. None If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
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