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1. Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study

Author

Patel, Vinod, Mazhar, Zia, Saich, Rebecca, Colleypriest, Ben, Tham, Tony C, Iqbal, Tariq, Kaushik, Vishal, Murugesan, Senthil, Singh, Salil, Weaver, Sean, Preston, Cathryn, Butt, Assad, Smith, Melissa, Basude, Dharamveer, Beale, Amanda, Langlands, Sarah, Direkze, Natalie, Parkes, Miles, Torrente, Franco, De La Revella Negro, Juan, MacDonald, Chris Ewen, Evans, Stephen M, Gunasekera, Anton VJ, Thakur, Alka, Elphick, David, Shenoy, Achuth, Nwokolo, Chuka U, Dhar, Anjan, Cole, Andrew T, Agrawal, Anurag, Bridger, Stephen, Doherty, Julie, Cooper, Sheldon C, de Silva, Shanika, Mowat, Craig, Mayhead, Phillip, Lees, Charlie, Jones, Gareth, Ahmad, Tariq, Hart, James W, Kennedy, Nicholas A, Goodhand, James R, Lin, Simeng, Chanchlani, Neil, Nice, Rachel, McDonald, Timothy J, Bewshea, Claire, Al-Nuaimi, Yusur, Richards, Ellen, Haigh, Richard, Greenish, Huw, Heath, Harry, Gaya, Daniel R, Russell, Richard K, Gervais, Lisa, Dunckley, Paul, Mahmood, Tariq, Banim, Paul JR, Sonwalkar, Sunil, Ghosh, Deb, Phillips, Rosemary H, Azaz, Amer, Sebastian, Shaji, Shenderey, Richard, Armstrong, Lawrence, Bell, Claire, Hariraj, Radhakrishnan, Matthews, Helen, Jafferbhoy, Hasnain, Selinger, Christian P, Zamvar, Veena, De Caestecker, John S, Willmott, Anne, Miller, Richard, Babu, Palani Sathish, Tzivinikos, Christos, Bloom, Stuart L, Chung-Faye, Guy, Croft, Nicholas M, Fell, John ME, Harbord, Marcus, Hart, Ailsa, Hope, Ben, Irving, Peter M, Lindsay, James O, Mawdsley, Joel E, McNair, Alistair, Monahan, Kevin J, Murray, Charles D, Orchard, Timothy, Paul, Thankam, Pollok, Richard, Shah, Neil, Bouri, Sonia, Johnson, Matt W, Modi, Anita, Kabiru, Kasamu Dawa, Baburajan, B K, Bhaduri, Bim, Fagbemi, Andrew Adebayo, Levison, Scott, Limdi, Jimmy K, Watts, Gill, Foley, Stephen, Ramadas, Arvind, MacFaul, George, Mansfield, John, Grellier, Leonie, Morris, Mary-Anne, Tremelling, Mark, Hawkey, Chris, Kirkham, Sian, Charlton, Charles PJ, Rodrigues, Astor, Simmons, Alison, Lewis, Stephen J, Snook, Jonathon, Tighe, Mark, Goggin, Patrick M, De Silva, Aminda N, Lal, Simon, Smith, Mark S, Panter, Simon, Cummings, JR Fraser, Dharmisari, Suranga, Carter, Martyn, Watts, David, Mahmood, Zahid, McLain, Bruce, Sen, Sandip, Pigott, Anna J, Hobday, David, Wesley, Emma, Johnston, Richard, Edwards, Cathryn, Beckly, John, Vani, Deven, Ramakrishnan, Subramaniam, Chaudhary, Rakesh, Trudgill, Nigel J, Cooney, Rachel, Bell, Andy, Prasad, Neeraj, Gordon, John N, Brookes, Matthew J, Li, Andy, Gore, Stephen, Hamilton, Benjamin, Thomas, Amanda, Smith, Rebecca, Roberts, Christopher, Bishara, Maria, and Lees, Charlie W

Published
2024
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2. Genome-Wide Methylation Profiling in 229 Patients With Crohn’s Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn’s Disease (TOPPIC)

Author

Arnott, Ian, Cahill, Aiden, Smith, Malcolm, Ahmad, Tariq, Subramanian, Sreedhar, Travis, Simon, Morris, John, Hamlin, John, Dhar, Anjan, Nwokolo, Chuka, Edwards, Cathryn, Creed, Tom, Bloom, Stuart, Yousif, Mohamed, Thomas, Linzi, Campbell, Simon, Lewis, Stephen J., Sebastian, Shaji, Sen, Sandip, Lal, Simon, Hawkey, Chris, Murray, Charles, Cummings, Fraser, Goh, Jason, Lindsay, James O., Arebi, Naila, Potts, Lindsay, McKinley, Aileen J., Thomson, John M., Todd, John A., Collie, Mhairi, Mowat, Ashley, Gaya, Daniel R., Winter, Jack, Naismith, Graham D., Ennis, Holly, Keerie, Catriona, Lewis, Steff, Prescott, Robin J., Lauc, Gordan, Campbell, Harry, McGovern, Dermot P.B., Annese, Vito, Zoldoš, Vlatka, Permberton, Iain K., Wuhrer, Manfred, Kolarich, Daniel, Fernandes, Daryl L., Theorodorou, Evropi, Daniel I. Spencer, Victoria Merrick, Gardner, Richard A., Doran, Ray, Shubhakar, Archana, Boyapati, Ray, Rudan, Igor, Lionetti, Paolo, Akmačić, Irena Trbojević, Krištić, Jasminka, Vuč ković, Frano, Štambuk, Jerko, Novokmet, Mislav, Pučić-Baković, Maja, Gornik, Olga, Andriulli, Angelo, Cantoro, Laura, Sturniolo, Giancarlo, Fiorino, Gionata, Manetti, Natalia, Latiano, Anna, Kohn, Anna, D’Inca`, Renata, Danese, Silvio, Arnott, Ian D., Noble, Colin L., Lees, Charlie W., Shand, Alan G., Ho, Gwo-Tzer, Murphy, Lee, Gibson, Jude, Evenden, Louise, Wrobel, Nicola, Gilchrist, Tamara, Fawkes, Angie, Kammeijer, Guinevere S.M., Clerc, Florent, de Haan, Noortje, Vojta, Aleksandar, Samaržija, Ivana, Markulin, Dora, Klasić, Marija, Dobrinić, Paula, Aulchenko, Yurii, van den Heuve, Tim, Jonkers, Daisy, Pierik, Marieke, Ventham, Nicholas T., Kennedy, Nicholas A., Kalla, Rahul, Adams, Alex T., Noble, Alexandra, Mowat, Craig, Dunlop, Malcolm G., and Satsangi, Jack

Published
2023
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3. Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study

Author

Chanchlani, Neil, primary, Lin, Simeng, additional, Bewshea, Claire, additional, Hamilton, Benjamin, additional, Thomas, Amanda, additional, Smith, Rebecca, additional, Roberts, Christopher, additional, Bishara, Maria, additional, Nice, Rachel, additional, Lees, Charlie W, additional, Sebastian, Shaji, additional, Irving, Peter M, additional, Russell, Richard K, additional, McDonald, Timothy J, additional, Goodhand, James R, additional, Ahmad, Tariq, additional, Kennedy, Nicholas A, additional, Patel, Vinod, additional, Mazhar, Zia, additional, Saich, Rebecca, additional, Colleypriest, Ben, additional, Tham, Tony C, additional, Iqbal, Tariq, additional, Kaushik, Vishal, additional, Murugesan, Senthil, additional, Singh, Salil, additional, Weaver, Sean, additional, Preston, Cathryn, additional, Butt, Assad, additional, Smith, Melissa, additional, Basude, Dharamveer, additional, Beale, Amanda, additional, Langlands, Sarah, additional, Direkze, Natalie, additional, Parkes, Miles, additional, Torrente, Franco, additional, De La Revella Negro, Juan, additional, MacDonald, Chris Ewen, additional, Evans, Stephen M, additional, Gunasekera, Anton VJ, additional, Thakur, Alka, additional, Elphick, David, additional, Shenoy, Achuth, additional, Nwokolo, Chuka U, additional, Dhar, Anjan, additional, Cole, Andrew T, additional, Agrawal, Anurag, additional, Bridger, Stephen, additional, Doherty, Julie, additional, Cooper, Sheldon C, additional, de Silva, Shanika, additional, Mowat, Craig, additional, Mayhead, Phillip, additional, Lees, Charlie, additional, Jones, Gareth, additional, Hart, James W, additional, Chanchlani, Neil, additional, Al-Nuaimi, Yusur, additional, Richards, Ellen, additional, Haigh, Richard, additional, Greenish, Huw, additional, Heath, Harry, additional, Gaya, Daniel R, additional, Gervais, Lisa, additional, Dunckley, Paul, additional, Mahmood, Tariq, additional, Banim, Paul JR, additional, Sonwalkar, Sunil, additional, Ghosh, Deb, additional, Phillips, Rosemary H, additional, Azaz, Amer, additional, Shenderey, Richard, additional, Armstrong, Lawrence, additional, Bell, Claire, additional, Hariraj, Radhakrishnan, additional, Matthews, Helen, additional, Jafferbhoy, Hasnain, additional, Selinger, Christian P, additional, Zamvar, Veena, additional, De Caestecker, John S, additional, Willmott, Anne, additional, Miller, Richard, additional, Babu, Palani Sathish, additional, Tzivinikos, Christos, additional, Bloom, Stuart L, additional, Chung-Faye, Guy, additional, Croft, Nicholas M, additional, Fell, John ME, additional, Harbord, Marcus, additional, Hart, Ailsa, additional, Hope, Ben, additional, Lindsay, James O, additional, Mawdsley, Joel E, additional, McNair, Alistair, additional, Monahan, Kevin J, additional, Murray, Charles D, additional, Orchard, Timothy, additional, Paul, Thankam, additional, Pollok, Richard, additional, Shah, Neil, additional, Bouri, Sonia, additional, Johnson, Matt W, additional, Modi, Anita, additional, Kabiru, Kasamu Dawa, additional, Baburajan, B K, additional, Bhaduri, Bim, additional, Fagbemi, Andrew Adebayo, additional, Levison, Scott, additional, Limdi, Jimmy K, additional, Watts, Gill, additional, Foley, Stephen, additional, Ramadas, Arvind, additional, MacFaul, George, additional, Mansfield, John, additional, Grellier, Leonie, additional, Morris, Mary-Anne, additional, Tremelling, Mark, additional, Hawkey, Chris, additional, Kirkham, Sian, additional, Charlton, Charles PJ, additional, Rodrigues, Astor, additional, Simmons, Alison, additional, Lewis, Stephen J, additional, Snook, Jonathon, additional, Tighe, Mark, additional, Goggin, Patrick M, additional, De Silva, Aminda N, additional, Lal, Simon, additional, Smith, Mark S, additional, Panter, Simon, additional, Cummings, JR Fraser, additional, Dharmisari, Suranga, additional, Carter, Martyn, additional, Watts, David, additional, Mahmood, Zahid, additional, McLain, Bruce, additional, Sen, Sandip, additional, Pigott, Anna J, additional, Hobday, David, additional, Wesley, Emma, additional, Johnston, Richard, additional, Edwards, Cathryn, additional, Beckly, John, additional, Vani, Deven, additional, Ramakrishnan, Subramaniam, additional, Chaudhary, Rakesh, additional, Trudgill, Nigel J, additional, Cooney, Rachel, additional, Bell, Andy, additional, Prasad, Neeraj, additional, Gordon, John N, additional, Brookes, Matthew J, additional, Li, Andy, additional, and Gore, Stephen, additional

Published
2024
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4. Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study

Author

Patel, Vinod, Mazhar, Zia, Saich, Rebecca, Colleypriest, Ben, Tham, Tony C, Iqbal, Tariq H, Kaushik, Vishal, Murugesan, Senthil, Singh, Salil, Weaver, Sean, Preston, Cathryn, Butt, Assad, Smith, Melissa, Basude, Dharamveer, Beale, Amanda, Langlands, Sarah, Direkze, Natalie, Parkes, Miles, Torrente, Franco, De La Revella Negro, Juan, MacDonald, Chris Ewen, Evans, Stephen M, Gunasekera, Anton V J, Thakur, Alka, Elphick, David, Shenoy, Achuth, Nwokolo, Chuka U, Dhar, Anjan, Cole, Andrew T, Agrawal, Anurag, Bridger, Stephen, Doherty, Julie, Cooper, Sheldon C, de Silva, Shanika, Mowat, Craig, Mayhead, Phillip, Lees, Charlie, Jones, Gareth, Ahmad, Tariq, Hart, James W, Gaya, Daniel R, Russell, Richard K, Gervais, Lisa, Dunckley, Paul, Mahmood, Tariq, Banim, Paul J R, Sonwalkar, Sunil, Ghosh, Deb, Phillips, Rosemary H, Azaz, Amer, Sebastian, Shaji, Shenderey, Richard, Armstrong, Lawrence, Bell, Claire, Hariraj, Radhakrishnan, Matthews, Helen, Jafferbhoy, Hasnain, Selinger, Christian P, Zamvar, Veena, De Caestecker, John S, Willmott, Anne, Miller, Richard, Babu, Palani Sathish, Tzivinikos, Christos, Bloom, Stuart L, Chung-Faye, Guy, Croft, Nicholas M, Fell, John ME, Harbord, Marcus, Hart, Ailsa, Hope, Ben, Irving, Peter M, Lindsay, James O, Mawdsley, Joel E, McNair, Alistair, Monahan, Kevin J, Murray, Charles D, Orchard, Timothy, Paul, Thankam, Pollok, Richard, Shah, Neil, Bouri, Sonia, Johnson, Matt W, Modi, Anita, Kabiru, Kasamu Dawa, Baburajan, B K, Bhaduri, Bim, Fagbemi, Andrew Adebayo, Levison, Scott, Limdi, Jimmy K, Watts, Gill, Foley, Stephen, Ramadas, Arvind, MacFaul, George, Mansfield, John, Grellier, Leonie, Morris, Mary-Anne, Tremelling, Mark, Hawkey, Chris, Kirkham, Sian, Charlton, Charles PJ, Rodrigues, Astor, Simmons, Alison, Lewis, Stephen J, Snook, Jonathon, Tighe, Mark, Goggin, Patrick M, De Silva, Aminda N, Lal, Simon, Smith, Mark S, Panter, Simon, Cummings, J R Fraser, Dharmisari, Suranga, Carter, Martyn, Watts, David, Mahmood, Zahid, McLain, Bruce, Sen, Sandip, Pigott, Anna J, Hobday, David, Wesley, Emma, Johnston, Richard, Edwards, Cathryn, Beckly, John, Vani, Deven, Ramakrishnan, Subramaniam, Chaudhary, Rakesh, Trudgill, Nigel J, Cooney, Rachel, Bell, Andy, Prasad, Neeraj, Gordon, John N, Brookes, Matthew J, Li, Andy, Gore, Stephen, Kennedy, Nicholas A, Heap, Graham A, Green, Harry D, Hamilton, Benjamin, Bewshea, Claire, Walker, Gareth J, Thomas, Amanda, Nice, Rachel, Perry, Mandy H, Chanchlani, Neil, Heerasing, Neel M, Hendy, Peter, Lin, Simeng, Lees, Charlie W, Hart, Ailsa L, Mansfield, John C, Lindsay, James, McDonald, Timothy J, McGovern, Dermot, and Goodhand, James R

Published
2019
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5. Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial

Author

Mowat, Craig, Arnott, Ian, Cahill, Aiden, Smith, Malcolm, Ahmad, Tariq, Subramanian, Sreedhar, Travis, Simon, Morris, John, Hamlin, John, Dhar, Anjan, Nwokolo, Chuka, Edwards, Cathryn, Creed, Tom, Bloom, Stuart, Yousif, Mohamed, Thomas, Linzi, Campbell, Simon, Lewis, Stephen J, Sebastian, Shaji, Sen, Sandip, Lal, Simon, Hawkey, Chris, Murray, Charles, Cummings, Fraser, Goh, Jason, Lindsay, James O, Arebi, Naila, Potts, Lindsay, McKinley, Aileen J, Thomson, John M, Todd, John A, Collie, Mhairi, Dunlop, Malcolm G, Mowat, Ashley, Gaya, Daniel R, Winter, Jack, Naismith, Graham D, Ennis, Holly, Keerie, Catriona, Lewis, Steff, Prescott, Robin J, Kennedy, Nicholas A, and Satsangi, Jack

Published
2016
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7. Genome-Wide Methylation Profiling in 229 Patients With Crohn’s Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn’s Disease (TOPPIC)

Author

Ventham, Nicholas T., primary, Kennedy, Nicholas A., additional, Kalla, Rahul, additional, Adams, Alex T., additional, Noble, Alexandra, additional, Ennis, Holly, additional, Mowat, Craig, additional, Dunlop, Malcolm G., additional, Satsangi, Jack, additional, Arnott, Ian, additional, Cahill, Aiden, additional, Smith, Malcolm, additional, Ahmad, Tariq, additional, Subramanian, Sreedhar, additional, Travis, Simon, additional, Morris, John, additional, Hamlin, John, additional, Dhar, Anjan, additional, Nwokolo, Chuka, additional, Edwards, Cathryn, additional, Creed, Tom, additional, Bloom, Stuart, additional, Yousif, Mohamed, additional, Thomas, Linzi, additional, Campbell, Simon, additional, Lewis, Stephen J., additional, Sebastian, Shaji, additional, Sen, Sandip, additional, Lal, Simon, additional, Hawkey, Chris, additional, Murray, Charles, additional, Cummings, Fraser, additional, Goh, Jason, additional, Lindsay, James O., additional, Arebi, Naila, additional, Potts, Lindsay, additional, McKinley, Aileen J., additional, Thomson, John M., additional, Todd, John A., additional, Collie, Mhairi, additional, Mowat, Ashley, additional, Gaya, Daniel R., additional, Winter, Jack, additional, Naismith, Graham D., additional, Keerie, Catriona, additional, Lewis, Steff, additional, Prescott, Robin J., additional, Lauc, Gordan, additional, Campbell, Harry, additional, McGovern, Dermot P.B., additional, Annese, Vito, additional, Zoldoš, Vlatka, additional, Permberton, Iain K., additional, Wuhrer, Manfred, additional, Kolarich, Daniel, additional, Fernandes, Daryl L., additional, Theorodorou, Evropi, additional, Daniel I. Spencer, Victoria Merrick, additional, Gardner, Richard A., additional, Doran, Ray, additional, Shubhakar, Archana, additional, Boyapati, Ray, additional, Rudan, Igor, additional, Lionetti, Paolo, additional, Akmačić, Irena Trbojević, additional, Krištić, Jasminka, additional, Vuč ković, Frano, additional, Štambuk, Jerko, additional, Novokmet, Mislav, additional, Pučić-Baković, Maja, additional, Gornik, Olga, additional, Andriulli, Angelo, additional, Cantoro, Laura, additional, Sturniolo, Giancarlo, additional, Fiorino, Gionata, additional, Manetti, Natalia, additional, Latiano, Anna, additional, Kohn, Anna, additional, D’Inca`, Renata, additional, Danese, Silvio, additional, Arnott, Ian D., additional, Noble, Colin L., additional, Lees, Charlie W., additional, Shand, Alan G., additional, Ho, Gwo-Tzer, additional, Murphy, Lee, additional, Gibson, Jude, additional, Evenden, Louise, additional, Wrobel, Nicola, additional, Gilchrist, Tamara, additional, Fawkes, Angie, additional, Kammeijer, Guinevere S.M., additional, Clerc, Florent, additional, de Haan, Noortje, additional, Vojta, Aleksandar, additional, Samaržija, Ivana, additional, Markulin, Dora, additional, Klasić, Marija, additional, Dobrinić, Paula, additional, Aulchenko, Yurii, additional, van den Heuve, Tim, additional, Jonkers, Daisy, additional, and Pierik, Marieke, additional

Published
2023
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13. A phase II study of laquinimod in Crohnʼs disease

Author

DʼHaens, Geert, Sandborn, William J, Colombel, Jean Frederic, Rutgeerts, Paul, Brown, Kurt, Barkay, Hadas, Sakov, Anat, Haviv, Asi, Feagan, Brian G, Baert, Filip, Dupas, Jean-Louis, Bouhnik, Yoram, Bonaz, Bruno, Hebuterne, Xavier, Allez, Matthieu, Israeli, Eran, Fraser, Gerald, Segol, Ori, Fishman, Sigal, Lahat, Adi, Melzer, Ehud, Pallone, Francesco, Campieri, Massimo, Gasbarrini, Antonio, Kohn, Anna, Vecchi, Maurizo, Ponsioen, Cyriel, Van der Woude, Janneke, Rydzewska, Grazyna, Mach, Tomasz, Paradowski, Leszek, Wright, John Philip, Watermeyer, Gillian Ann, Pettengell, Keith Edward, Mahomed, Adam Dawood, Prins, Maarten Jeroen, Aboo, Nazimuddin, Diaz, Julian Panes, Taxonera, Carlos, Gisbert, Javier, Hinojosa, Joaquin, Garcia, Fernand Gomollon, Sanchez, Valle Garcia, Parkes, Miles, Probert, Chris, Leiper, Keith, Nwokolo, Chuka, Mayberry, John, and Bloom, Stuart

Published
2015
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14. Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn’s disease: long-term outcomes for 11 928 patients in the UK inflammatory bowel disease bioresource

Author

Stournaras, Evangelos, Qian, Wendi, Pappas, Apostolos, Hong, You Yi, Shawky, Rasha, UK IBD BioResource Investigators, Raine, Tim, Parkes, Miles, UK IBD Bioresource Investigators, Ahmad, Tariq, Kennedy, Nick, Irving, Peter, Prescott, Natalie, Lees, Charlie, Mansfield, John, Lamb, Chris, Satsangi, Jack, Simmons, Alison, Hart, Alisa, Subramanian, Sreedhar, Probert, Chris, Shenderey, Richard, Gunasekera, Anton, Kok, Klaartje Bel, Javaid, Babur, Sinha, Leena, Singh, Salil, Preston, Cathryn, Jarvis, Mark, Penn, Ruth, Dhar, Anjan, Shenoy, Achuth, Phillis, Kath, Oglesby, Arabis, Tilbury, Jude, Scott, Glyn, Collum, Joseph, Carter, Martyn, Barbour, Jamie, Gordon, John, Ramage, John, Sivagi, Ganesh, Roberts, Phil, Bose, Monica, Sebastian, Shaji, Wilkins, Joy, Banim, Paul, Kent, Alexana, Verma, Ajay, Warren, Dawn, Wiles, Alan, Johnson, Matthew, Koss, Konrad, Oza, Chirag, Elamin, Khalid, Woods, Annette, Baburajan, Bijay, MacDonald, Chris, Theron, Byron, Tremelling, Mark, Shmueli, Udi, Bevan, Roisin, Limdi, Jimmy, Nair, Prakash, Vani, Deven, Lewis, Stephen, Baker-Moffat, Michelle, Moran, Gordon, McLaughlin, Simon, Silva, Aminda De, Beckly, John, Cole, Anew, Murray, Charles, Lobo, Alan, Smith, Melissa, Mathew, Sanju, Saunders, John, Steed, Helen, Brookes, Matthew, Loehry, Juliette, Rahman, Monira, Butterworth, Jeff, Muddu, Ajay, Clark, Katie, Selinger, Christian, Ramadas, Arvind, McLaughlin, John, Pollok, Richard, Rees, Colin, Panter, Simon, Hobday, David, Foley, Stephen, Patel, Vinod, Wesley, Emma, Gavin, Daniel, Edwards, Cathryn, Bloom, Stuart, Nwokolo, Chuka, DeCaestecker, John, Hanna, Mina, Davies, Albert, Hancock, Laura, Cummings, Fraser, Ramakrishnan, Subramaniam, Tindall, Theresa, Landy, Jonathan, Appleby, Richard, Sharpstone, Dan, Li, Andy, Keld, Richard, Mear, Lin, Philips, Anne, Willia, Horace, Ben Warner, Laura Hancock, Durai, Dharmaraj, Brinkworth, Elaine, Mahmood, Zahid, Cooney, Rachel, Stournaras, Evangelos [0000-0002-9885-0673], Parkes, Miles [0000-0002-6467-0631], and Apollo - University of Cambridge Repository

Subjects
azathioprine, tolerance, crohn's disease, 6-mercaptopurine, Inflammatory bowel disease, ulcerative colitis
Abstract

Objective: Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date, we assessed the long-term effectiveness of thiopurines in ulcerative colitis (UC) and Crohn’s disease (CD), including their impact on need for surgery. Design: Outcomes were assessed in 11 928 patients (4968 UC, 6960 CD) in the UK IBD BioResource initiated on thiopurine monotherapy with the intention of maintaining medically induced remission. Effectiveness was assessed retrospectively using patient-level data and a definition that required avoidance of escalation to biological therapy or surgery while on thiopurines. Analyses included overall effectiveness, time-to-event analysis for treatment escalation and comparison of surgery rates in patients tolerant or intolerant of thiopurines. Results: Using 68 132 patient-years of exposure, thiopurine monotherapy appeared effective for the duration of treatment in 2617/4968 (52.7%) patients with UC compared with 2378/6960 (34.2%) patients with CD (p

Published
2020
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23. HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn’s Disease

Author

Sazonovs, Aleksejs, primary, Kennedy, Nicholas A., additional, Moutsianas, Loukas, additional, Heap, Graham A., additional, Rice, Daniel L., additional, Reppell, Mark, additional, Bewshea, Claire M., additional, Chanchlani, Neil, additional, Walker, Gareth J., additional, Perry, Mandy H., additional, McDonald, Timothy J., additional, Lees, Charlie W., additional, Cummings, J.R. Fraser, additional, Parkes, Miles, additional, Mansfield, John C., additional, Irving, Peter M., additional, Barrett, Jeffrey C., additional, McGovern, Dermot, additional, Goodhand, James R., additional, Anderson, Carl A., additional, Ahmad, Tariq, additional, Patel, Vinod, additional, Mazhar, Zia, additional, Saich, Rebecca, additional, Colleypriest, Ben, additional, Tham, Tony C, additional, Iqbal, Tariq H, additional, Kaushik, Vishal, additional, Murugesan, Senthil, additional, Singh, Salil, additional, Weaver, Sean, additional, Preston, Cathryn, additional, Butt, Assad, additional, Smith, Melissa, additional, Basude, Dharamveer, additional, Beale, Amanda, additional, Langlands, Sarah, additional, Direkze, Natalie, additional, Torrente, Franco, additional, De La Revella Negro, Juan, additional, Ewen MacDonald, Chris, additional, Evans, Stephen M, additional, Gunasekera, Anton V J, additional, Thakur, Alka, additional, Elphick, David, additional, Shenoy, Achuth, additional, Nwokolo, Chuka U, additional, Dhar, Anjan, additional, Cole, Andrew T, additional, Agrawal, Anurag, additional, Bridger, Stephen, additional, Doherty, Julie, additional, Cooper, Sheldon C, additional, de Silva, Shanika, additional, Mowat, Craig, additional, Mayhead, Phillip, additional, Lees, Charlie, additional, Jones, Gareth, additional, Hart, James W, additional, Gaya, Daniel R, additional, Russell, Richard K, additional, Gervais, Lisa, additional, Dunckley, Paul, additional, Mahmood, Tariq, additional, Banim, Paul J R, additional, Sonwalkar, Sunil, additional, Ghosh, Deb, additional, Phillips, Rosemary H, additional, Azaz, Amer, additional, Sebastian, Shaji, additional, Shenderey, Richard, additional, Armstrong, Lawrence, additional, Bell, Claire, additional, Hariraj, Radhakrishnan, additional, Matthews, Helen, additional, Jafferbhoy, Hasnain, additional, Selinger, Christian P, additional, Zamvar, Veena, additional, De Caestecker, John S, additional, Willmott, Anne, additional, Miller, Richard, additional, Sathish Babu, Palani, additional, Tzivinikos, Christos, additional, Bloom, Stuart L, additional, Chung-Faye, Guy, additional, Croft, Nicholas M, additional, Fell, John ME, additional, Harbord, Marcus, additional, Hart, Ailsa, additional, Hope, Ben, additional, Irving, Peter M, additional, Lindsay, James O, additional, Mawdsley, Joel E, additional, McNair, Alistair, additional, Monahan, Kevin J, additional, Murray, Charles D, additional, Orchard, Timothy, additional, Paul, Thankam, additional, Pollok, Richard, additional, Shah, Neil, additional, Bouri, Sonia, additional, Johnson, Matt W, additional, Modi, Anita, additional, Dawa Kabiru, Kasamu, additional, Baburajan, B K, additional, Bhaduri, Bim, additional, Adebayo Fagbemi, Andrew, additional, Levison, Scott, additional, Limdi, Jimmy K, additional, Watts, Gill, additional, Foley, Stephen, additional, Ramadas, Arvind, additional, MacFaul, George, additional, Mansfield, John, additional, Grellier, Leonie, additional, Morris, Mary-Anne, additional, Tremelling, Mark, additional, Hawkey, Chris, additional, Kirkham, Sian, additional, Charlton, Charles PJ, additional, Rodrigues, Astor, additional, Simmons, Alison, additional, Lewis, Stephen J, additional, Snook, Jonathon, additional, Tighe, Mark, additional, Goggin, Patrick M, additional, De Silva, Aminda N, additional, Lal, Simon, additional, Smith, Mark S, additional, Panter, Simon, additional, Cummings, Fraser, additional, Dharmisari, Suranga, additional, Carter, Martyn, additional, Watts, David, additional, Mahmood, Zahid, additional, McLain, Bruce, additional, Sen, Sandip, additional, Pigott, Anna J, additional, Hobday, David, additional, Wesley, Emma, additional, Johnston, Richard, additional, Edwards, Cathryn, additional, Beckly, John, additional, Vani, Deven, additional, Ramakrishnan, Subramaniam, additional, Chaudhary, Rakesh, additional, Trudgill, Nigel J, additional, Cooney, Rachel, additional, Bell, Andy, additional, Prasad, Neeraj, additional, Gordon, John N, additional, Brookes, Matthew J, additional, Li, Andy, additional, and Gore, Stephen, additional

Published
2020
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29. Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study

Author

Kennedy, Nicholas A, primary, Heap, Graham A, additional, Green, Harry D, additional, Hamilton, Benjamin, additional, Bewshea, Claire, additional, Walker, Gareth J, additional, Thomas, Amanda, additional, Nice, Rachel, additional, Perry, Mandy H, additional, Bouri, Sonia, additional, Chanchlani, Neil, additional, Heerasing, Neel M, additional, Hendy, Peter, additional, Lin, Simeng, additional, Gaya, Daniel R, additional, Cummings, J R Fraser, additional, Selinger, Christian P, additional, Lees, Charlie W, additional, Hart, Ailsa L, additional, Parkes, Miles, additional, Sebastian, Shaji, additional, Mansfield, John C, additional, Irving, Peter M, additional, Lindsay, James, additional, Russell, Richard K, additional, McDonald, Timothy J, additional, McGovern, Dermot, additional, Goodhand, James R, additional, Ahmad, Tariq, additional, Patel, Vinod, additional, Mazhar, Zia, additional, Saich, Rebecca, additional, Colleypriest, Ben, additional, Tham, Tony C, additional, Iqbal, Tariq H, additional, Kaushik, Vishal, additional, Murugesan, Senthil, additional, Singh, Salil, additional, Weaver, Sean, additional, Preston, Cathryn, additional, Butt, Assad, additional, Smith, Melissa, additional, Basude, Dharamveer, additional, Beale, Amanda, additional, Langlands, Sarah, additional, Direkze, Natalie, additional, Torrente, Franco, additional, De La Revella Negro, Juan, additional, MacDonald, Chris Ewen, additional, Evans, Stephen M, additional, Gunasekera, Anton V J, additional, Thakur, Alka, additional, Elphick, David, additional, Shenoy, Achuth, additional, Nwokolo, Chuka U, additional, Dhar, Anjan, additional, Cole, Andrew T, additional, Agrawal, Anurag, additional, Bridger, Stephen, additional, Doherty, Julie, additional, Cooper, Sheldon C, additional, de Silva, Shanika, additional, Mowat, Craig, additional, Mayhead, Phillip, additional, Lees, Charlie, additional, Jones, Gareth, additional, Hart, James W, additional, Gervais, Lisa, additional, Dunckley, Paul, additional, Mahmood, Tariq, additional, Banim, Paul J R, additional, Sonwalkar, Sunil, additional, Ghosh, Deb, additional, Phillips, Rosemary H, additional, Azaz, Amer, additional, Shenderey, Richard, additional, Armstrong, Lawrence, additional, Bell, Claire, additional, Hariraj, Radhakrishnan, additional, Matthews, Helen, additional, Jafferbhoy, Hasnain, additional, Zamvar, Veena, additional, De Caestecker, John S, additional, Willmott, Anne, additional, Miller, Richard, additional, Babu, Palani Sathish, additional, Tzivinikos, Christos, additional, Bloom, Stuart L, additional, Chung-Faye, Guy, additional, Croft, Nicholas M, additional, Fell, John ME, additional, Harbord, Marcus, additional, Hart, Ailsa, additional, Hope, Ben, additional, Lindsay, James O, additional, Mawdsley, Joel E, additional, McNair, Alistair, additional, Monahan, Kevin J, additional, Murray, Charles D, additional, Orchard, Timothy, additional, Paul, Thankam, additional, Pollok, Richard, additional, Shah, Neil, additional, Johnson, Matt W, additional, Modi, Anita, additional, Kabiru, Kasamu Dawa, additional, Baburajan, B K, additional, Bhaduri, Bim, additional, Fagbemi, Andrew Adebayo, additional, Levison, Scott, additional, Limdi, Jimmy K, additional, Watts, Gill, additional, Foley, Stephen, additional, Ramadas, Arvind, additional, MacFaul, George, additional, Mansfield, John, additional, Grellier, Leonie, additional, Morris, Mary-Anne, additional, Tremelling, Mark, additional, Hawkey, Chris, additional, Kirkham, Sian, additional, Charlton, Charles PJ, additional, Rodrigues, Astor, additional, Simmons, Alison, additional, Lewis, Stephen J, additional, Snook, Jonathon, additional, Tighe, Mark, additional, Goggin, Patrick M, additional, De Silva, Aminda N, additional, Lal, Simon, additional, Smith, Mark S, additional, Panter, Simon, additional, Dharmisari, Suranga, additional, Carter, Martyn, additional, Watts, David, additional, Mahmood, Zahid, additional, McLain, Bruce, additional, Sen, Sandip, additional, Pigott, Anna J, additional, Hobday, David, additional, Wesley, Emma, additional, Johnston, Richard, additional, Edwards, Cathryn, additional, Beckly, John, additional, Vani, Deven, additional, Ramakrishnan, Subramaniam, additional, Chaudhary, Rakesh, additional, Trudgill, Nigel J, additional, Cooney, Rachel, additional, Bell, Andy, additional, Prasad, Neeraj, additional, Gordon, John N, additional, Brookes, Matthew J, additional, Li, Andy, additional, and Gore, Stephen, additional

Published
2019
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30. Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus

Author

Palles, Claire, Chegwidden, Laura, Li, Xinzhong, Findlay, John M., Farnham, Garry, Castro Giner, Francesc, Peppelenbosch, Maikel P., Kovac, Michal, Adams, Claire L., Prenen, Hans, Briggs, Sarah, Harrison, Rebecca, Sanders, Scott, MacDonald, David, Haigh, Chris, Tucker, Art, Love, Sharon, Nanji, Manoj, deCaestecker, John, Ferry, David, Rathbone, Barrie, Hapeshi, Julie, Barr, Hugh, Moayyedi, Paul, Watson, Peter, Zietek, Barbara, Maroo, Neera, Gay, Laura, Underwood, Tim, Boulter, Lisa, McMurtry, Hugh, Monk, David, Patel, Praful, Ragunath, Krish, Al Dulaimi, David, Murray, Iain, Koss, Konrad, Veitch, Andrew, Trudgill, Nigel, Nwokolo, Chuka, Rembacken, Bjorn, Atherfold, Paul, Green, Elaine, Ang, Yeng, Kuipers, Ernst J., Chow, Wu, Paterson, Stuart, Kadri, Sudarshan, Beales, Ian, Grimley, Charles, Mullins, Paul, Beckett, Conrad, Farrant, Mark, Dixon, Andrew, Kelly, Sean, Johnson, Matthew, Wajed, Shahjehan, Dhar, Anjan, Sawyer, Elinor, Roylance, Rebecca, Onstad, Lynn, Gammon, Marilie D., Corley, Douglas A., Shaheen, Nicholas J., Bird, Nigel C., Hardie, Laura J., Reid, Brian J., Ye, Weimin, Liu, Geoffrey, Romero, Yvonne, Bernstein, Leslie, Wu, Anna H., Casson, Alan G., Fitzgerald, Rebecca, Whiteman, David C., Risch, Harvey A., Levine, David M., Vaughan, Tom L., Verhaar, Auke P., van den Brande, Jan, Toxopeus, Eelke L., Spaander, Manon C., Wijnhoven, Bas P.L., van der Laan, Luc J.W., Krishnadath, Kausilia, Wijmenga, Cisca, Trynka, Gosia, McManus, Ross, Reynolds, John V., O’Sullivan, Jacintha, MacMathuna, Padraic, McGarrigle, Sarah A., Kelleher, Dermot, Vermeire, Severine, Cleynen, Isabelle, Bisschops, Raf, Tomlinson, Ian, and Jankowski, Janusz

Subjects
Risk, Esophageal Neoplasms, LD, linkage disequilibrium, ASE, allele-specific expression, eQTL, expression quantitative trait locus, Polymorphism, Single Nucleotide, Barrett Esophagus, Intestinal Metaplasia, Full Report: Basic and Translational—Alimentary Tract, BE, Barrett’s esophagus, Humans, Genetic Predisposition to Disease, EAC, esophageal adenocarcinoma, EAC, GWAS, genome-wide association study, Original Research, Cancer, BEACON, Barrett's and Esophageal Adenocarcinoma Consortium, Gastroenterology, PC, principal component, SNP, single nucleotide polymorphism, A300, CI, confidence interval, OR, odds ratio, Growth Differentiation Factors, Susceptibility, Bone Morphogenetic Proteins, TCGA, The Cancer Genome Atlas, Human medicine, T-Box Domain Proteins, Genome-Wide Association Study
Abstract

Background & Aims\ud Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q23, where the closest protein-coding gene is FOXF1. Subsequently, the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) identified risk loci for BE and esophageal adenocarcinoma near CRTC1 and BARX1, and within 100 kb of FOXP1. We aimed to identify further SNPs that increased BE risk and to validate previously reported associations.\ud \ud Methods\ud We performed a genome-wide association study (GWAS) to identify variants associated with BE and further analyzed promising variants identified by BEACON by genotyping 10,158 patients with BE and 21,062 controls.\ud \ud Results\ud We identified 2 SNPs not previously associated with BE: rs3072 (2p24.1; odds ratio [OR] = 1.14; 95% CI: 1.09–1.18; P = 1.8 × 10−11) and rs2701108 (12q24.21; OR = 0.90; 95% CI: 0.86–0.93; P = 7.5 × 10−9). The closest protein-coding genes were respectively GDF7 (rs3072), which encodes a ligand in the bone morphogenetic protein pathway, and TBX5 (rs2701108), which encodes a transcription factor that regulates esophageal and cardiac development. Our data also supported in BE cases 3 risk SNPs identified by BEACON (rs2687201, rs11789015, and rs10423674). Meta-analysis of all data identified another SNP associated with BE and esophageal adenocarcinoma: rs3784262, within ALDH1A2 (OR = 0.90; 95% CI: 0.87–0.93; P = 3.72 × 10−9).\ud \ud Conclusions\ud We identified 2 loci associated with risk of BE and provided data to support a further locus. The genes we found to be associated with risk for BE encode transcription factors involved in thoracic, diaphragmatic, and esophageal development or proteins involved in the inflammatory response.

Published
2015
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31. An assessment of candidate genes to assist prognosis in gastric cancer

Author

McFarlane, Michael, Brettschneider, Julia, Gelsthorpe, Adrian, James, Sean, Snead, David, Gopalakrishnan, Kishore, Mehenna, Hisham, Jankowski, Janusz, Arasaradnam, Ramesh, Nwokolo, Chuka, McFarlane, Michael, Brettschneider, Julia, Gelsthorpe, Adrian, James, Sean, Snead, David, Gopalakrishnan, Kishore, Mehenna, Hisham, Jankowski, Janusz, Arasaradnam, Ramesh, and Nwokolo, Chuka

Abstract

Gastric cancer (GC) is the fourth commonest cancer worldwide, with the second highest mortality rate. Its poor mortality is linked to delayed presentation. There is a drive towards non-invasive biomarker screening and monitoring of many different types of cancer, although with limited success so far. We aimed to determine if any genes from a 32-gene panel could be used to determine GC prognosis. We carried out a retrospective study on the expression of 32 genes, selected for their proven or potential links to GC, on historic formalin fixed paraffin-embedded (FFPE) GC specimens from our unit. Gene expression was measured using quantitative nuclease protection assays (qNPA) technology. Following statistical analysis of the results, immunohistochemical staining for eight genes, both discriminating and non-discriminating, was conducted in seven age and sex matched non-metastatic: metastatic GC pairings. The stained samples were reviewed by two blinded consultant histopathologists. Multivariate Cox analysis of the gene expression data revealed metastatic status, age, sex and five genes appeared to influence GC survival. Genes negatively influencing survival included and (relative risks 2.20, 3.73 and 7.53 respectively). Genes conveying survival benefit included and (relative risks 0.10 and 0.24 respectively). Immunohistochemical staining of seven age and sex matched non-metastatic: metastatic pairs revealed no association between gene expression and protein expression. Our study found several genes whose expression may affect GC prognosis. However, immunohistochemical analysis revealed no association between gene expression and protein expression. It remains to be determined whether gene expression or protein expression are reliable means of assessing GC prognosis.

Published
2018

35. Variation in gas and volatile compound emissions from human urine as it ages, measured by an electronic nose

Author

Esfahani, Siavash, Sagar, Nidhi M., Kyrou, Ioannis, Mozdiak, Ella, O'Connell, Nicola, Nwokolo, Chuka, Bardhan, Karna D., Arasaradnam, Ramesh P., Covington, James A., Esfahani, Siavash, Sagar, Nidhi M., Kyrou, Ioannis, Mozdiak, Ella, O'Connell, Nicola, Nwokolo, Chuka, Bardhan, Karna D., Arasaradnam, Ramesh P., and Covington, James A.

Abstract

The medical profession is becoming ever more interested in the use of gas-phase biomarkers for disease identification and monitoring. This is due in part to its rapid analysis time and low test cost, which makes it attractive for many different clinical arenas. One technology that is showing promise for analyzing these gas-phase biomarkers is the electronic nose-an instrument designed to replicate the biological olfactory system. Of the possible biological media available to "sniff", urine is becoming ever more important as it is easy to collect and to store for batch testing. However, this raises the question of sample storage shelf-life, even at -80 °C. Here we investigated the effect of storage time (years) on stability and reproducibility of total gas/vapour emissions from urine samples. Urine samples from 87 patients with Type 2 Diabetes Mellitus were collected over a four-year period and stored at -80 °C. These samples were then analyzed using FAIMS (field-asymmetric ion mobility spectrometry-a type of electronic nose). It was discovered that gas emissions (concentration and diversity) reduced over time. However, there was less variation in the initial nine months of storage with greater uniformity and stability of concentrations together with tighter clustering of the total number of chemicals released. This suggests that nine months could be considered a general guide to a sample shelf-life.

Published
2016

43. Sa1264 A Randomised, Double-Blind, Placebo-Controlled, Parallel Group, Multi-Centred Pilot Study to Assess the Symptomatic Treatment of Ulcerative Colitis With Cannabidiol

Author

Irving, Peter M., primary, Iqbal, Tariq, additional, Nwokolo, Chuka, additional, Subramanian, Sreedhar, additional, Bloom, Stuart L., additional, Prasad, Neeraj, additional, Hart, Ailsa, additional, Murray, Charles, additional, Lindsay, James O., additional, Taylor, Adam, additional, Barron, Rachel, additional, and Wright, Stephen, additional

Published
2015
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45. Differentiating Coeliac Disease from Irritable Bowel Syndrome by Urinary Volatile Organic Compound Analysis – A Pilot Study

Author

Arasaradnam, Ramesh P., primary, Westenbrink, Eric, additional, McFarlane, Michael J., additional, Harbord, Ruth, additional, Chambers, Samantha, additional, O’Connell, Nicola, additional, Bailey, Catherine, additional, Nwokolo, Chuka U., additional, Bardhan, Karna D., additional, Savage, Richard, additional, and Covington, James A., additional

Published
2014
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46. Detection of Colorectal Cancer (CRC) by Urinary Volatile Organic Compound Analysis

Author

Arasaradnam, Ramesh P., primary, McFarlane, Michael J., additional, Ryan-Fisher, Courtenay, additional, Westenbrink, Erik, additional, Hodges, Paula, additional, Thomas, Matthew G., additional, Chambers, Samantha, additional, O'Connell, Nicola, additional, Bailey, Catherine, additional, Harmston, Christopher, additional, Nwokolo, Chuka U., additional, Bardhan, Karna D., additional, and Covington, James A., additional

Published
2014
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48. Tu1255 Detection of Urinary Volatile Organic Compounds in Patients With Inflammatory Bowel Disease and Controls by an Electronic Nose -A Transatlantic Study

Author

Covington, James, primary, Harbord, Ruth, additional, Westenbrink, Eric W., additional, Bailey, Catherine, additional, O'connell, Nicola, additional, Dhaliwal, Amritpal, additional, Nwokolo, Chuka, additional, Foley, Anne, additional, Marya, Neil B., additional, Baptista, Veronica, additional, Dev Bardhan, Karna, additional, Cave, David R., additional, and Arasaradnam, Ramesh, additional

Published
2014
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49. Su1453 Distinguishing Coeliac Disease (CD) From Irritable Bowel Syndrome (IBS) by Urine Volatile Organic Compound Analysis. A Pilot Study

Author

Covington, James, primary, Harbord, Ruth, additional, Westenbrink, Eric W., additional, Chambers, Samantha, additional, McFarlane, Michael, additional, Dhaliwal, Amritpal, additional, Oconnell, Nicola C., additional, Bailey, Catherine, additional, Nwokolo, Chuka, additional, Bardhan, Karna Dev, additional, and Arasaradnam, Ramesh, additional

Published
2014
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50. Nigeria decides

Author

Nwokolo, Chuka and Annor, Ekua A.

Subjects
General interest, Government, Business, international
Abstract

It was refreshing to read New Africans report on Nigerian elections (NA, February 2015). Nigerians in the Diaspora receive their political news from many sources including an extensive network in [...]

Published
2015

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