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1. Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa

Author

Janivara, Rohini, Chen, Wenlong C., Hazra, Ujani, Baichoo, Shakuntala, Agalliu, Ilir, Kachambwa, Paidamoyo, Simonti, Corrine N., Brown, Lyda M., Tambe, Saanika P., Kim, Michelle S., Harlemon, Maxine, Jalloh, Mohamed, Muzondiwa, Dillon, Naidoo, Daphne, Ajayi, Olabode O., Snyper, Nana Yaa, Niang, Lamine, Diop, Halimatou, Ndoye, Medina, Mensah, James E., Abrahams, Afua O. D., Biritwum, Richard, Adjei, Andrew A., Adebiyi, Akindele O., Shittu, Olayiwola, Ogunbiyi, Olufemi, Adebayo, Sikiru, Nwegbu, Maxwell M., Ajibola, Hafees O., Oluwole, Olabode P., Jamda, Mustapha A., Pentz, Audrey, Haiman, Christopher A., Spies, Petrus V., van der Merwe, André, Cook, Michael B., Chanock, Stephen J., Berndt, Sonja I., Watya, Stephen, Lubwama, Alexander, Muchengeti, Mazvita, Doherty, Sean, Smyth, Natalie, Lounsbury, David, Fortier, Brian, Rohan, Thomas E., Jacobson, Judith S., Neugut, Alfred I., Hsing, Ann W., Gusev, Alexander, Aisuodionoe-Shadrach, Oseremen I., Joffe, Maureen, Adusei, Ben, Gueye, Serigne M., Fernandez, Pedro W., McBride, Jo, Andrews, Caroline, Petersen, Lindsay N., Lachance, Joseph, and Rebbeck, Timothy R.

Published
2024
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2. Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa

Author

Kim, Michelle S., Naidoo, Daphne, Hazra, Ujani, Quiver, Melanie H., Chen, Wenlong C., Simonti, Corinne N., Kachambwa, Paidamoyo, Harlemon, Maxine, Agalliu, Ilir, Baichoo, Shakuntala, Fernandez, Pedro, Hsing, Ann W., Jalloh, Mohamed, Gueye, Serigne M., Niang, Lamine, Diop, Halimatou, Ndoye, Medina, Snyper, Nana Yaa, Adusei, Ben, Mensah, James E., Abrahams, Afua O. D., Biritwum, Richard, Adjei, Andrew A., Adebiyi, Akindele O., Shittu, Olayiwola, Ogunbiyi, Olufemi, Adebayo, Sikiru, Aisuodionoe-Shadrach, Oseremen I., Nwegbu, Maxwell M., Ajibola, Hafees O., Oluwole, Olabode P., Jamda, Mustapha A., Singh, Elvira, Pentz, Audrey, Joffe, Maureen, Darst, Burcu F., Conti, David V., Haiman, Christopher A., Spies, Petrus V., van der Merwe, André, Rohan, Thomas E., Jacobson, Judith, Neugut, Alfred I., McBride, Jo, Andrews, Caroline, Petersen, Lindsay N., Rebbeck, Timothy R., and Lachance, Joseph

Published
2022
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4. Table S4 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa

Author

Harlemon, Maxine, primary, Ajayi, Olabode, primary, Kachambwa, Paidamoyo, primary, Kim, Michelle S., primary, Simonti, Corinne N., primary, Quiver, Melanie H., primary, Petersen, Desiree C., primary, Mittal, Anuradha, primary, Fernandez, Pedro W., primary, Hsing, Ann W., primary, Baichoo, Shakuntala, primary, Agalliu, Ilir, primary, Jalloh, Mohamed, primary, Gueye, Serigne M., primary, Snyper, Nana Yaa F., primary, Adusei, Ben, primary, Mensah, James E., primary, Abrahams, Afua O.D., primary, Adebiyi, Akindele O., primary, Orunmuyi, Akin T., primary, Aisuodionoe-Shadrach, Oseremen I., primary, Nwegbu, Maxwell M., primary, Joffe, Maureen, primary, Chen, Wenlong C., primary, Irusen, Hayley, primary, Neugut, Alfred I., primary, Quintana, Yuri, primary, Seutloali, Moleboheng, primary, Fadipe, Mayowa B., primary, Warren, Christopher, primary, Woehrmann, Marcos H., primary, Zhang, Peng, primary, Ongaco, Chrissie M., primary, Mawhinney, Michelle, primary, McBride, Jo, primary, Andrews, Caroline V., primary, Adams, Marcia, primary, Pugh, Elizabeth, primary, Rebbeck, Timothy R., primary, Petersen, Lindsay N., primary, and Lachance, Joseph, primary

Published
2023
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5. Data from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa

Author

Harlemon, Maxine, primary, Ajayi, Olabode, primary, Kachambwa, Paidamoyo, primary, Kim, Michelle S., primary, Simonti, Corinne N., primary, Quiver, Melanie H., primary, Petersen, Desiree C., primary, Mittal, Anuradha, primary, Fernandez, Pedro W., primary, Hsing, Ann W., primary, Baichoo, Shakuntala, primary, Agalliu, Ilir, primary, Jalloh, Mohamed, primary, Gueye, Serigne M., primary, Snyper, Nana Yaa F., primary, Adusei, Ben, primary, Mensah, James E., primary, Abrahams, Afua O.D., primary, Adebiyi, Akindele O., primary, Orunmuyi, Akin T., primary, Aisuodionoe-Shadrach, Oseremen I., primary, Nwegbu, Maxwell M., primary, Joffe, Maureen, primary, Chen, Wenlong C., primary, Irusen, Hayley, primary, Neugut, Alfred I., primary, Quintana, Yuri, primary, Seutloali, Moleboheng, primary, Fadipe, Mayowa B., primary, Warren, Christopher, primary, Woehrmann, Marcos H., primary, Zhang, Peng, primary, Ongaco, Chrissie M., primary, Mawhinney, Michelle, primary, McBride, Jo, primary, Andrews, Caroline V., primary, Adams, Marcia, primary, Pugh, Elizabeth, primary, Rebbeck, Timothy R., primary, Petersen, Lindsay N., primary, and Lachance, Joseph, primary

Published
2023
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6. Figure S1 from A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa

Author

Harlemon, Maxine, primary, Ajayi, Olabode, primary, Kachambwa, Paidamoyo, primary, Kim, Michelle S., primary, Simonti, Corinne N., primary, Quiver, Melanie H., primary, Petersen, Desiree C., primary, Mittal, Anuradha, primary, Fernandez, Pedro W., primary, Hsing, Ann W., primary, Baichoo, Shakuntala, primary, Agalliu, Ilir, primary, Jalloh, Mohamed, primary, Gueye, Serigne M., primary, Snyper, Nana Yaa F., primary, Adusei, Ben, primary, Mensah, James E., primary, Abrahams, Afua O.D., primary, Adebiyi, Akindele O., primary, Orunmuyi, Akin T., primary, Aisuodionoe-Shadrach, Oseremen I., primary, Nwegbu, Maxwell M., primary, Joffe, Maureen, primary, Chen, Wenlong C., primary, Irusen, Hayley, primary, Neugut, Alfred I., primary, Quintana, Yuri, primary, Seutloali, Moleboheng, primary, Fadipe, Mayowa B., primary, Warren, Christopher, primary, Woehrmann, Marcos H., primary, Zhang, Peng, primary, Ongaco, Chrissie M., primary, Mawhinney, Michelle, primary, McBride, Jo, primary, Andrews, Caroline V., primary, Adams, Marcia, primary, Pugh, Elizabeth, primary, Rebbeck, Timothy R., primary, Petersen, Lindsay N., primary, and Lachance, Joseph, primary

Published
2023
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8. Additional file 2 of Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa

Author

Kim, Michelle S., Naidoo, Daphne, Hazra, Ujani, Quiver, Melanie H., Chen, Wenlong C., Simonti, Corinne N., Kachambwa, Paidamoyo, Harlemon, Maxine, Agalliu, Ilir, Baichoo, Shakuntala, Fernandez, Pedro, Hsing, Ann W., Jalloh, Mohamed, Gueye, Serigne M., Niang, Lamine, Diop, Halimatou, Ndoye, Medina, Snyper, Nana Yaa, Adusei, Ben, Mensah, James E., Abrahams, Afua O. D., Biritwum, Richard, Adjei, Andrew A., Adebiyi, Akindele O., Shittu, Olayiwola, Ogunbiyi, Olufemi, Adebayo, Sikiru, Aisuodionoe-Shadrach, Oseremen I., Nwegbu, Maxwell M., Ajibola, Hafees O., Oluwole, Olabode P., Jamda, Mustapha A., Singh, Elvira, Pentz, Audrey, Joffe, Maureen, Darst, Burcu F., Conti, David V., Haiman, Christopher A., Spies, Petrus V., van der Merwe, André, Rohan, Thomas E., Jacobson, Judith, Neugut, Alfred I., McBride, Jo, Andrews, Caroline, Petersen, Lindsay N., Rebbeck, Timothy R., and Lachance, Joseph

Abstract

Additional file 2: Table S2. Ability of PRS to distinguish between case and control status using a shared set of variants for both continental datasets.

Published
2022
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9. Additional file 4 of Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa

Author

Kim, Michelle S., Naidoo, Daphne, Hazra, Ujani, Quiver, Melanie H., Chen, Wenlong C., Simonti, Corinne N., Kachambwa, Paidamoyo, Harlemon, Maxine, Agalliu, Ilir, Baichoo, Shakuntala, Fernandez, Pedro, Hsing, Ann W., Jalloh, Mohamed, Gueye, Serigne M., Niang, Lamine, Diop, Halimatou, Ndoye, Medina, Snyper, Nana Yaa, Adusei, Ben, Mensah, James E., Abrahams, Afua O. D., Biritwum, Richard, Adjei, Andrew A., Adebiyi, Akindele O., Shittu, Olayiwola, Ogunbiyi, Olufemi, Adebayo, Sikiru, Aisuodionoe-Shadrach, Oseremen I., Nwegbu, Maxwell M., Ajibola, Hafees O., Oluwole, Olabode P., Jamda, Mustapha A., Singh, Elvira, Pentz, Audrey, Joffe, Maureen, Darst, Burcu F., Conti, David V., Haiman, Christopher A., Spies, Petrus V., van der Merwe, André, Rohan, Thomas E., Jacobson, Judith, Neugut, Alfred I., McBride, Jo, Andrews, Caroline, Petersen, Lindsay N., Rebbeck, Timothy R., and Lachance, Joseph

Abstract

Additional file 4. Peer review history.

Published
2022
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10. Additional file 3 of Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa

Author

Kim, Michelle S., Naidoo, Daphne, Hazra, Ujani, Quiver, Melanie H., Chen, Wenlong C., Simonti, Corinne N., Kachambwa, Paidamoyo, Harlemon, Maxine, Agalliu, Ilir, Baichoo, Shakuntala, Fernandez, Pedro, Hsing, Ann W., Jalloh, Mohamed, Gueye, Serigne M., Niang, Lamine, Diop, Halimatou, Ndoye, Medina, Snyper, Nana Yaa, Adusei, Ben, Mensah, James E., Abrahams, Afua O. D., Biritwum, Richard, Adjei, Andrew A., Adebiyi, Akindele O., Shittu, Olayiwola, Ogunbiyi, Olufemi, Adebayo, Sikiru, Aisuodionoe-Shadrach, Oseremen I., Nwegbu, Maxwell M., Ajibola, Hafees O., Oluwole, Olabode P., Jamda, Mustapha A., Singh, Elvira, Pentz, Audrey, Joffe, Maureen, Darst, Burcu F., Conti, David V., Haiman, Christopher A., Spies, Petrus V., van der Merwe, André, Rohan, Thomas E., Jacobson, Judith, Neugut, Alfred I., McBride, Jo, Andrews, Caroline, Petersen, Lindsay N., Rebbeck, Timothy R., and Lachance, Joseph

Abstract

Additional file 3: Table S3. Ability of PRS to distinguish between aggressive and non-aggressive forms of CaP using the optimal set of variants for European and African datasets.

Published
2022
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13. Prevalence and Determinants of Masked Hypertension in Nigeria: The REMAH Study

Author

Odili, Augustine N, primary, Danladi, Benjamin, additional, Chori, Babangida S, additional, Oshaju, Henry, additional, Nwakile, Peter C, additional, Okoye, Innocent C, additional, Abdullahi, Umar, additional, Nwegbu, Maxwell M, additional, Zawaya, Kefas, additional, Essien, Ime, additional, Sada, Kabiru, additional, Ogedengbe, John O, additional, Aje, Akinyemi, additional, and Isiguzo, Godsent C, additional

Published
2020
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14. Urinary sodium excretion and its association with blood pressure in Nigeria: A nationwide population survey

Author

Odili, Augustine N., primary, Chori, Babangida S., additional, Danladi, Benjamin, additional, Nwakile, Peter C., additional, Okoye, Innocent C., additional, Abdullahi, Umar, additional, Zawaya, Kefas, additional, Essien, Ime, additional, Sada, Kabiru, additional, Nwegbu, Maxwell M., additional, Ogedengbe, John O., additional, Aje, Akinyemi, additional, and Isiguzo, Godsent C., additional

Published
2020
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15. A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa

Author

Harlemon, Maxine, primary, Ajayi, Olabode, additional, Kachambwa, Paidamoyo, additional, Kim, Michelle S., additional, Simonti, Corinne N., additional, Quiver, Melanie H., additional, Petersen, Desiree C., additional, Mittal, Anuradha, additional, Fernandez, Pedro W., additional, Hsing, Ann W., additional, Baichoo, Shakuntala, additional, Agalliu, Ilir, additional, Jalloh, Mohamed, additional, Gueye, Serigne M., additional, Snyper, Nana Yaa F., additional, Adusei, Ben, additional, Mensah, James E., additional, Abrahams, Afua O.D., additional, Adebiyi, Akindele O., additional, Orunmuyi, Akin T., additional, Aisuodionoe-Shadrach, Oseremen I., additional, Nwegbu, Maxwell M., additional, Joffe, Maureen, additional, Chen, Wenlong C., additional, Irusen, Hayley, additional, Neugut, Alfred I., additional, Quintana, Yuri, additional, Seutloali, Moleboheng, additional, Fadipe, Mayowa B., additional, Warren, Christopher, additional, Woehrmann, Marcos H., additional, Zhang, Peng, additional, Ongaco, Chrissie M., additional, Mawhinney, Michelle, additional, McBride, Jo, additional, Andrews, Caroline V., additional, Adams, Marcia, additional, Pugh, Elizabeth, additional, Rebbeck, Timothy R., additional, Petersen, Lindsay N., additional, and Lachance, Joseph, additional

Published
2020
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17. A custom genotyping array reveals population-level heterogeneity for the genetic risks of prostate cancer and other cancers in Africa

Author

Harlemon, Maxine, primary, Ajayi, Olabode, additional, Kachambwa, Paidamoyo, additional, Kim, Michelle S., additional, Simonti, Corinne N., additional, Quiver, Melanie H., additional, Petersen, Desiree C., additional, Mittal, Anuradha, additional, Fernandez, Pedro, additional, Hsing, Ann W., additional, Baichoo, Shakuntala, additional, Agalliu, Ilir, additional, Jalloh, Mohamed, additional, Gueye, Serigne M., additional, Snyper, Nana Yaa, additional, Adusei, Ben, additional, Mensah, James E., additional, Abrahams, Afua O.D., additional, Adebiyi, Akindele O., additional, Orunmuyi, Akin, additional, Aisuodionoe-Shadrach, Oseremen I., additional, Nwegbu, Maxwell M., additional, Joffe, Maureen, additional, Chen, Wenlong C., additional, Irusen, Hayley, additional, Neugut, Alfred I., additional, Quintana, Yuri, additional, Seutloali, Moleboheng, additional, Fadipe, Mayowa, additional, Warren, Christopher, additional, Woehrmann, Marcos H., additional, Zhang, Peng, additional, Ongaco, Chrissie, additional, Mawhinney, Michelle, additional, McBride, Jo, additional, Andrews, Caroline, additional, Adams, Marcia, additional, Pugh, Elizabeth, additional, Rebbeck, Timothy R., additional, Petersen, Lindsay, additional, and Lachance, Joseph, additional

Published
2019
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18. Prevalence and Determinants of Masked Hypertension in Nigeria: The REMAH Study.

Author

Odili, Augustine N, Danladi, Benjamin, Chori, Babangida S, Oshaju, Henry, Nwakile, Peter C, Okoye, Innocent C, Abdullahi, Umar, Nwegbu, Maxwell M, Zawaya, Kefas, Essien, Ime, Sada, Kabiru, Ogedengbe, John O, Aje, Akinyemi, and Isiguzo, Godsent C

Subjects
BLOOD pressure, SPHYGMOMANOMETERS, BLOOD sugar, AMBULATORY blood pressure monitoring, HYPERTENSION, ODDS ratio, CONFIDENCE intervals
Abstract

Background Estimating the burden of hypertension in Nigeria hitherto relied on clinic blood pressure (BP) measurement alone. This excludes individuals with masked hypertension (MH), i.e. normotensive clinic but hypertensive out-of-clinic BP. Methods In a nationally representative sample of adult Nigerians, we obtained clinic BP using auscultatory method and out-of-clinic BP by self-measured home BP with semi-automated oscillometric device. Clinic BP was average of 5 consecutive measurements and home BP was average of 3 days duplicate morning and evening readings. MH was clinic BP <140 mm Hg systolic and 90 mm Hg diastolic and home BP ≥135 mm Hg systolic and/or 85 mm Hg diastolic. Results Among 933 participants, the prevalence of sustained hypertension, MH, and white-coat hypertension was 28.3%, 7.9%, and 11.9%, respectively. Among subjects whose clinic BP were in the normotensive range (n = 558), the prevalence of MH was 13%; 12% among untreated and 27% among treated individuals. The mutually adjusted odds ratios of having MH among all participants with normotensive clinic BP were 1.33 (95% confidence interval, 1.10–1.60) for a 10-year higher age, 1.59 (1.09–2.40) for a 10 mm Hg increment in systolic clinic BP, and 1.16 (1.08–1.28) for a 10 mg/dl higher random blood glucose. The corresponding estimates in the untreated population were 1.24 (1.03–1.51), 1.56 (1.04–2.44), and 1.16 (1.08–1.29), respectively. Conclusions MH is common in Nigeria and increasing age, clinic systolic BP, and random blood glucose are the risk factors. [ABSTRACT FROM AUTHOR]

Published
2021
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19. Office and Home Blood Pressures as Determinants of Electrocardiographic Left Ventricular Hypertrophy Among Black Nigerians Compared With White Flemish

Author

Odili, Augustine N, primary, Thijs, Lutgarde, additional, Yang, Wen-Yi, additional, Ogedengbe, John O, additional, Nwegbu, Maxwell M, additional, Jacobs, Lotte, additional, Wei, Fang-Fei, additional, Feng, Ying-Mei, additional, Zhang, Zhen-Yu, additional, Kuznetsova, Tatiana, additional, Nawrot, Tim S, additional, and Staessen, Jan A, additional

Published
2017
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20. Preliminary Evaluation of a Point-of-Care Testing Device (SickleSCAN™) in Screening for Sickle Cell Disease

Author

Nwegbu, Maxwell M., primary, Isa, Hezekiah A., additional, Nwankwo, Biyaya B., additional, Okeke, Chinedu C., additional, Edet-Offong, Uduak J., additional, Akinola, Norah O., additional, Adekile, Adekunle D., additional, Aneke, John C., additional, Okocha, Emmanuel C., additional, Ulasi, Thomas, additional, Abjah, Usman, additional, Ugwu, Ngozi I., additional, Okolo, Angela A., additional, Madu, Anazoeze, additional, Emodi, Ifeoma, additional, Girei, Ahmed, additional, Balogun, Taiwo M., additional, Diaku-Akinwumi, Ijeoma N., additional, Ohiaeri, Chinatu, additional, Brown, Biobele J., additional, Olaniyi, John A., additional, Hassan, Abdulaziz, additional, Awwalu, Sani, additional, Okoh, Dorothy A., additional, and Nnodu, Obiageli E., additional

Published
2017
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21. Prevalence and Determinants of Masked Hypertension Among Black Nigerians Compared With a Reference Population

Author

Odili, Augustine N., primary, Thijs, Lutgarde, additional, Hara, Azusa, additional, Wei, Fang-Fei, additional, Ogedengbe, John O., additional, Nwegbu, Maxwell M., additional, Aparicio, Lucas S., additional, Asayama, Kei, additional, Niiranen, Teemu J., additional, Boggia, José, additional, Luzardo, Leonella, additional, Jacobs, Lotte, additional, Stergiou, George S., additional, Johansson, Jouni K., additional, Ohkubo, Takayoshi, additional, Jula, Antti M., additional, Imai, Yutaka, additional, O’Brien, Eoin, additional, and Staessen, Jan A., additional

Published
2016
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24. The post-Ebola virus disease scourge in Nigeria: Individual levels of preparedness among physicians in the Federal Capital Territory Abuja.

Author

Alli, Adewale L., Nwegbu, Maxwell M., Ibekwe, Perpetua U., and Ibekwe, Titus S.

Subjects
*EBOLA virus disease, *VIRUS diseases, *PROTECTIVE clothing, *HEALTH of physicians
Abstract

Background: Ebola virus disease (EVD) is a viral hemorrhagic illness with great propensity for spread across international borders. The latest outbreak in the West African region, which involved Nigeria, was the worst among previously documented 25 outbreaks since discovery in 1976. The Nigerian response toward attaining Ebola free status was phenomenal and a case study for most nations. However, the persistence of EVD in West Africa is still a risk to recurrence, hence, the need to assess the level of consciousness of Nigerian physicians towards this. Methodology: A cross-sectional study utilizing the instrument of a pretested semi-structured questionnaire was conducted among physicians practicing within the federal capital city of Nigeria. General knowledge, treatment, prevention, and reporting of EVD were assessed and appropriate statistical analyses done using SPSS 20. Results: Of the 101 respondents, 45% and 87% showed excellent level (>80% score) of "general knowledge" and "reporting" on EVD, respectively. However, only 51% respondents had good (60-80%) knowledge on EVD treatment. Three percent correctly identified the "EVD helpline" phone-numbers for reporting suspected cases. Furthermore, 43.6% admitted the availability of personal protective equipment (PPE) in their hospitals while 35.6% had witnessed a demonstration of the use. The distribution of the PPEs appeared skewed -74.4% (teaching-hospitals), 16% (private-hospitals), and the primary health care centers (9.6%). Conclusion: A majority of the physicians showed good level of preparedness as it relates to general knowledge on EVD, knowledge on good clinical practice, use of protocols and standard precautions and PPE. The identification of deficits in knowledge on treatment of EVD and flow path for the notification of suspected cases requires urgent redress given the risk of re-occurrence in the country. [ABSTRACT FROM AUTHOR]

Published
2016
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25. The sensitivity and specificity of Lassa virus IgM by ELISA as screening tool at early phase of Lassa fever infection.

Author

Ibekwe, Titus S., Nwegbu, Maxwell M., Asogun, Daniel, Adomeh, Donatus I., and Okokhere, Peter O.

Subjects
*LASSA fever, *LASSA fever virus, *IMMUNOGLOBULIN M, *ENZYME-linked immunosorbent assay, *REVERSE transcriptase polymerase chain reaction, *SEROLOGY, *THERAPEUTICS
Abstract

Background: Early diagnosis, prompt treatment, and disease containment are vital measures in the management of Lassa fever (LF), a lethal and contagious arenaviral hemorrhagic disease prevalent in West Africa. Lassa Virus (LAV)-specific Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) test, the gold standard for diagnosis, is unavailable in most centers. Serologic detection of LAV IgM is a more accessible tool and this work was to investigate its adequacy as an early marker for LF. Patients and Methods: A prospective case-control study conducted July 2007-March 2011 in a tertiary referral health center in Nigeria. Blood samples for test and control were evaluated for Lassa specific antigens and IgM using RT-PCR (primers S36+ and LVS 339) and indirect ELISA (Lassa Nucleo-protein (NP)-Antigen) respectively. RT-PCR outcome was used as standard to test for the sensitivity and specificity of IgM. Results: Of the 37 confirmed cases of LF infection by RT-PCR, 21 (57%) were IgM positive. Amongst the 35 confirmed negative cases (control group), eight were IgM positive. The diagnostic sensitivity and specificity of the IgM assay were 57% and 77% respectively. The negative and positive predictive values of the IgM serological assay were 63% and 72%, respectively, while the efficiency of the test was 67%. Conclusion: The specificity and sensitivity of IgM as a screening tool for early detection of LF appear weak and, hence, the need for a reliable LF "rapid screening kit" since RT-PCR is unavailable in most centers. In the interim, "high clinical index of suspicion," irrespective of IgM status, requires urgent referral to confirmatory centers. [ABSTRACT FROM AUTHOR]

Published
2012
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