Search

Your search keyword '"Nuttall, Jacqui"' showing total 32 results
Start Over Author "Nuttall, Jacqui"
32 results on '"Nuttall, Jacqui"'

1. Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people

Author

Sach, Tracey H., Onoja, Mary, Clarke, Holly, Santer, Miriam, Muller, Ingrid, Becque, Taeko, Stuart, Beth, Hooper, Julie, Steele, Mary, Wilczynska, Sylvia, Ridd, Matthew J., Roberts, Amanda, Ahmed, Amina, Yardley, Lucy, Little, Paul, Greenwell, Kate, Sivyer, Katy, Nuttall, Jacqui, Griffiths, Gareth, Lawton, Sandra, Langan, Sinéad M., Howells, Laura, Leighton, Paul, Williams, Hywel C., and Thomas, Kim S.

Published
2024
Full Text
View/download PDF

2. Nasal sprays and behavioural interventions compared with usual care for acute respiratory illness in primary care: a randomised, controlled, open-label, parallel-group trial

Author

Little, Paul, Vennik, Jane, Rumsby, Kate, Stuart, Beth, Becque, Taeko, Moore, Michael, Francis, Nick, Hay, Alastair D, Verheij, Theo, Bradbury, Katherine, Greenwell, Kate, Dennison, Laura, Holt, Sian, Denison-Day, James, Ainsworth, Ben, Raftery, James, Thomas, Tammy, Butler, Christopher C, Richards-Hall, Samantha, Smith, Deb, Patel, Hazel, Williams, Samantha, Barnett, Jane, Middleton, Karen, Miller, Sascha, Johnson, Sophie, Nuttall, Jacqui, Webley, Fran, Sach, Tracey, Yardley, Lucy, and Geraghty, Adam W A

Published
2024
Full Text
View/download PDF

4. Talking in primary care (TIP): protocol for a cluster-randomised controlled trial in UK primary care to assess clinical and cost-effectiveness of communication skills e-learning for practitioners on patients’ musculoskeletal pain and enablement

Author

Bishop, Felicity L, primary, Cross, Nadia, additional, Dewar-Haggart, Rachel, additional, Teasdale, Emma, additional, Herbert, Amy, additional, Robinson, Michelle E, additional, Ridd, Matthew J, additional, Mallen, Christian, additional, Clarson, Lorna, additional, Bostock, Jennifer, additional, Becque, Taeko, additional, Stuart, Beth, additional, Garfield, Kirsty, additional, Morrison, Leanne, additional, Pollet, Sebastien, additional, Vennik, Jane, additional, Atherton, Helen, additional, Howick, Jeremy, additional, Leydon, Geraldine M, additional, Nuttall, Jacqui, additional, Islam, Nazrul, additional, Lee, Paul H, additional, Little, Paul, additional, and Everitt, Hazel A, additional

Published
2024
Full Text
View/download PDF

6. Cost-effectiveness of Spironolactone for Adult Female Acne (SAFA): economic evaluation alongside a randomised controlled trial

Author

Pyne, Sarah, primary, Sach, Tracey H, additional, Lawrence, Megan, additional, Renz, Susanne, additional, Eminton, Zina, additional, Stuart, Beth, additional, Thomas, Kim S, additional, Francis, Nick, additional, Soulsby, Irene, additional, Thomas, Karen, additional, Permyakova, Natalia V, additional, Ridd, Matthew J, additional, Little, Paul, additional, Muller, Ingrid, additional, Nuttall, Jacqui, additional, Griffiths, Gareth, additional, Layton, Alison M, additional, and Santer, Miriam, additional

Published
2023
Full Text
View/download PDF

7. Factors that influence women’s enrolment and ongoing participation in a partially decentralised randomised controlled dermatology trial: a qualitative interview study with participants in the SAFA (Spironolactone for Adult Female Acne) trial

Author

Boxall, Cherish, primary, Renz, Susanne, additional, Eminton, Zina, additional, Nuttall, Jacqui, additional, Saji, Alan, additional, Cluff, Charlotte, additional, Wilcox, Christopher, additional, Muller, Ingrid, additional, Layton, Alison, additional, Soulsby, Irene, additional, and Santer, Miriam, additional

Published
2023
Full Text
View/download PDF

8. Effectiveness of spironolactone for women with acne vulgaris (SAFA) in England and Wales: pragmatic, multicentre, phase 3, double blind, randomised controlled trial

Author

Santer, Miriam, primary, Lawrence, Megan, additional, Renz, Susanne, additional, Eminton, Zina, additional, Stuart, Beth, additional, Sach, Tracey H, additional, Pyne, Sarah, additional, Ridd, Matthew J, additional, Francis, Nick, additional, Soulsby, Irene, additional, Thomas, Karen, additional, Permyakova, Natalia, additional, Little, Paul, additional, Muller, Ingrid, additional, Nuttall, Jacqui, additional, Griffiths, Gareth, additional, Thomas, Kim S, additional, and Layton, Alison M, additional

Published
2023
Full Text
View/download PDF

10. Eczema Care Online behavioural interventions to support self-care for children and young people: two independent, pragmatic, randomised controlled trials

Author

Santer, Miriam, primary, Muller, Ingrid, additional, Becque, Taeko, additional, Stuart, Beth, additional, Hooper, Julie, additional, Steele, Mary, additional, Wilczynska, Sylvia, additional, Sach, Tracey H, additional, Ridd, Matthew J, additional, Roberts, Amanda, additional, Ahmed, Amina, additional, Yardley, Lucy, additional, Little, Paul, additional, Greenwell, Kate, additional, Sivyer, Katy, additional, Nuttall, Jacqui, additional, Griffiths, Gareth, additional, Lawton, Sandra, additional, Langan, Sinéad M, additional, Howells, Laura M, additional, Leighton, Paul, additional, Williams, Hywel C, additional, and Thomas, Kim S, additional

Published
2022
Full Text
View/download PDF

12. Eczema Care Online behavioural interventions to support selfcare for children and young people: two independent, pragmatic, randomised controlled trials.

Author

Santer, Miriam, Muller, Ingrid, Becque, Taeko, Stuart, Beth, Hooper, Julie, Steele, Mary, Wilczynska, Sylvia, Sach, Tracey H., Ridd, Matthew J., Roberts, Amanda, Ahmed, Amina, Yardley, Lucy, Little, Paul, Greenwell, Kate, Sivyer, Katy, Nuttall, Jacqui, Griffiths, Gareth, Lawton, Sandra, Langan, Sinéad M., and Howells, Laura M.

Subjects
ATOPIC dermatitis treatment, STATISTICS, CAREGIVERS, CONFIDENCE intervals, ADRENOCORTICAL hormones, SELF-management (Psychology), INTERNET, MEDICAL care, BEHAVIOR therapy, UNCERTAINTY, TREATMENT effectiveness, RANDOMIZED controlled trials, SEVERITY of illness index, QUALITY of life, DESCRIPTIVE statistics, QUESTIONNAIRES, REPEATED measures design, ATOPIC dermatitis, DERMATOLOGIC agents, INTRACLASS correlation, RESEARCH funding, STATISTICAL sampling, DATA analysis software, LOGISTIC regression analysis, PSYCHOLOGICAL adaptation, CUTANEOUS therapeutics, STATISTICAL models, DATA analysis, PARENTS, LONGITUDINAL method, ADULTS, ADOLESCENCE
Published
2022
Full Text
View/download PDF

13. Spironolactone for adult female acne (SAFA): protocol for a double-blind, placebo-controlled, phase III randomised study of spironolactone as systemic therapy for acne in adult women

Author

Renz, Susanne, primary, Chinnery, Fay, additional, Stuart, Beth, additional, Day, Laura, additional, Muller, Ingrid, additional, Soulsby, Irene, additional, Nuttall, Jacqui, additional, Thomas, Karen, additional, Thomas, Kim Suzanne, additional, Sach, Tracey, additional, Stanton, Louise, additional, Ridd, Matthew J, additional, Francis, Nick, additional, Little, Paul, additional, Eminton, Zina, additional, Griffiths, Gareth, additional, Layton, Alison M, additional, and Santer, Miriam, additional

Published
2021
Full Text
View/download PDF

14. Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial

Author

Curzen, Nick, primary, Nicholas, Zoe, additional, Stuart, Beth, additional, Wilding, Sam, additional, Hill, Kayleigh, additional, Shambrook, James, additional, Eminton, Zina, additional, Ball, Darran, additional, Barrett, Camilla, additional, Johnson, Lucy, additional, Nuttall, Jacqui, additional, Fox, Kim, additional, Connolly, Derek, additional, O’Kane, Peter, additional, Hobson, Alex, additional, Chauhan, Anoop, additional, Uren, Neal, additional, Mccann, Gerry, additional, Berry, Colin, additional, Carter, Justin, additional, Roobottom, Carl, additional, Mamas, Mamas, additional, Rajani, Ronak, additional, Ford, Ian, additional, Douglas, Pamela, additional, and Hlatky, Mark, additional

Published
2021
Full Text
View/download PDF

15. Home and Online Management and Evaluation of Blood Pressure (HOME BP) using a digital intervention in poorly controlled hypertension: randomised controlled trial

Author

McManus, Richard J., Little, Paul, Stuart, Beth, Morton, Katherine, Raftery, James, Kelly, Jo, Bradbury, Katherine, Zhang, Jin, Zhu, Shihua, Murray, Elizabeth, May, Carl R., Mair, Frances S., Michie, Susan, Smith, Peter, Band, Rebecca, Ogburn, Emma, Allen, Julie, Rice, Cathy, Nuttall, Jacqui, Williams, Bryan, Yardley, Lucy, HOME BP investigators, Jones, Adam, Hussain, Ajmal, McHardy, Alistair, Harrison, Anna, LaLonde, Anna, Malik, Asim, Hernandez-Diaz, Basilio, Cranfield, Ben, Nicholson, Brian, Anandan, Carl, Neden, Catherine, Bobrow, Cathy, Evans, Chloe, Keast, Christopher, Henderson, Clare, Sutherland, Corrine, Kyte, Craig, Henderson, Dan, Noble, Debbie, Capo-Bianco, Ed, Williams, Edward, Shaw, Elizabeth, Mohri, Fatima, Asal, Gaurav, Dougall, Greig, Bhupal, Hardeep, Luckhurst, Heidi, Dosanjh, Hergeven, Nowell, Hilary, Brown, Jan, Flett, Jennifer, Barber, Julian, Rutter, Heather, Thompson, Julian, Ramanan, Kanjhana, Madronal, Karen, Malone, Karen, Etherington, Katie, Tsoi, Kenney, Knox, Kyle, Amin, Laila, Hirst, Lisa, Allen, Lucy, Skellern, Luke, Flynn, Lynne, McEwan, Lorne, Pugsley, Mark, Frassen, Marloes, Gaw, Matthew, Prendergast, Matthew, Wallard, Matthew, Faisal, Muhammad, Wooding, Nick, Lees, Nienke, Wainman, Paul, Nanda, Nithya, Moore, Patrick, Conley, Paul, Johnson, Paul, Wilson, Penny, Jacobs, Phillip, Whitbred, Pippa, Zamir, Rebecca, Reed, Richard, Tribley, Richard, Woof, Richard, Danson, Ruth, Lawes, Ruth, Gallagher, Sarah, Wadsworth, Sarah, Macanovic, Serge, Cartwright, Simon, Pettitt, Simon, Tucker, Simon, Doggett, Stephen, Sevenoaks, Tamsin, Watson, Tara, Talbot, Tess, Imrie, Ruth, Herbert, Thomas, Crockett, Tony, Wright, Tony, Sharma, Vanshika, Telford, Vicki, Almashta, Zaid, Cheng, Zelda, Ali, Zishan, Grube, Alice, Claxton, Andy, Asante, Barbara, Weare, Becki, McKee, Eleanor, Werrett, Bertha, Barwell, Carmel, Mulvihill, Carole, Sherwood, Caroline, MacDonald, Clare, Tabor, Dadirayi, Denning, Dawn, Roberts, Debbie, Adshead, Diane, Clarke, Gemma, Huntley, Heather, Pinder, Heather, Qasim, Irene, Merrison, Jane, King, Jill, Allison, Julie, Johal, Kam, Terry, Karen, Wood, Karine, Balmford, Kathryn, Barnes, Katie, Post, Katie, Bowden, Kelly-Marie, Edmunds, Kirsty, Whittle, Klaire, Peniket, Lara, Carnegie, Leann, Neale, Linda, Davey, Lisa, Bartlett, Liz, Smith, Louise, Clack, Lucy, Brown, Martina, McKenna, Naomi, Kay, Pam, Jacobs, Polly, Cutts, Rebecca, Pearse, Robert, Atkinson, Ruth, Barter, Sally, Mackie, Sally, Norris, Sam, Cook, Sandra, Elderfield, Sarah, Nzante, Sarah, Cronin, Sharon, Maslen, Sophie, Marchant, Stephanie, Wright, Stephanie, Keene, Sue, Smith, Sue, Cimelli, Suzie, Stone, Tracy, Joyce, Tricia, Le Marechal, Trudie, Kettle, Vicky, Osborne, Victoria, Cubiss, Wendy, Marsden, Wendy, Kowalczyk-Williams, Wioletta, and Bailey, Zoe

Abstract

Objective: The HOME BP (Home and Online Management and Evaluation of Blood Pressure) trial aimed to test a digital intervention for hypertension management in primary care by combining self-monitoring of blood pressure with guided self-management. Design: Unmasked randomised controlled trial with automated ascertainment of primary endpoint. Setting: 76 general practices in the United Kingdom. Participants: 622 people with treated but poorly controlled hypertension (>140/90 mm Hg) and access to the internet. Interventions: Participants were randomised by using a minimisation algorithm to self-monitoring of blood pressure with a digital intervention (305 participants) or usual care (routine hypertension care, with appointments and drug changes made at the discretion of the general practitioner; 317 participants). The digital intervention provided feedback of blood pressure results to patients and professionals with optional lifestyle advice and motivational support. Target blood pressure for hypertension, diabetes, and people aged 80 or older followed UK national guidelines. Main outcome measures: The primary outcome was the difference in systolic blood pressure (mean of second and third readings) after one year, adjusted for baseline blood pressure, blood pressure target, age, and practice, with multiple imputation for missing values. Results: After one year, data were available from 552 participants (88.6%) with imputation for the remaining 70 participants (11.4%). Mean blood pressure dropped from 151.7/86.4 to 138.4/80.2 mm Hg in the intervention group and from 151.6/85.3 to 141.8/79.8 mm Hg in the usual care group, giving a mean difference in systolic blood pressure of −3.4 mm Hg (95% confidence interval −6.1 to −0.8 mm Hg) and a mean difference in diastolic blood pressure of −0.5 mm Hg (−1.9 to 0.9 mm Hg). Results were comparable in the complete case analysis and adverse effects were similar between groups. Within trial costs showed an incremental cost effectiveness ratio of £11 ($15, €12; 95% confidence interval £6 to £29) per mm Hg reduction. Conclusions: The HOME BP digital intervention for the management of hypertension by using self-monitored blood pressure led to better control of systolic blood pressure after one year than usual care, with low incremental costs. Implementation in primary care will require integration into clinical workflows and consideration of people who are digitally excluded. Trial registration: ISRCTN13790648.

Published
2021

18. Home and Online Management and Evaluation of Blood Pressure (HOME BP) using a digital intervention in poorly controlled hypertension: randomised controlled trial

Author

McManus, Richard J, Little, Paul, Stuart, Beth, Morton, Katherine, Raftery, James, Kelly, Jo, Bradbury, Katherine, Zhang, Jin, Zhu, Shihua, Murray, Elizabeth, May, Carl R, Mair, Frances S, Michie, Susan, Smith, Peter, Band, Rebecca, Ogburn, Emma, Allen, Julie, Rice, Cathy, Nuttall, Jacqui, Williams, Bryan, Yardley, Lucy, Jones, Adam, Hussain, Ajmal, McHardy, Alistair, Harrison, Anna, LaLonde, Anna, Malik, Asim, Hernandez-Diaz, Basilio, Cranfield, Ben, Nicholson, Brian, Anandan, Carl, Neden, Catherine, Bobrow, Cathy, Evans, Chloe, Keast, Christopher, Henderson, Clare, Sutherland, Corrine, Kyte, Craig, Henderson, Dan, Noble, Debbie, Capo-Bianco, Ed, Williams, Edward, Shaw, Elizabeth, Mohri, Fatima, Asal, Gaurav, Dougall, Greig, Bhupal, Hardeep, Luckhurst, Heidi, Dosanjh, Hergeven, Nowell, Hilary, Brown, Jan, Flett, Jennifer, Barber, Julian, Rutter, Heather, Thompson, Julian, Ramanan, Kanjhana, Madronal, Karen, Malone, Karen, Etherington, Katie, Tsoi, Kenney, Knox, Kyle, Amin, Laila, Hirst, Lisa, Allen, Lucy, Skellern, Luke, Flynn, Lynne, McEwan, Lorne, Pugsley, Mark, Frassen, Marloes, Gaw, Matthew, Prendergast, Matthew, Wallard, Matthew, Faisal, Muhammad, Wooding, Nick, Lees, Nienke, Wainman, Paul, Nanda, Nithya, Moore, Patrick, Conley, Paul, Johnson, Paul, Wilson, Penny, Jacobs, Phillip, Whitbred, Pippa, Zamir, Rebecca, Reed, Richard, Tribley, Richard, Woof, Richard, Danson, Ruth, Lawes, Ruth, Gallagher, Sarah, Wadsworth, Sarah, Macanovic, Serge, Cartwright, Simon, Pettitt, Simon, Tucker, Simon, Doggett, Stephen, Sevenoaks, Tamsin, Watson, Tara, Talbot, Tess, Imrie, Ruth, Herbert, Thomas, Crockett, Tony, Wright, Tony, Sharma, Vanshika, Telford, Vicki, Almashta, Zaid, Cheng, Zelda, Ali, Zishan, Grube, Alice, Claxton, Andy, Asante, Barbara, Weare, Becki, McKee, Eleanor, Werrett, Bertha, Barwell, Carmel, Mulvihill, Carole, Sherwood, Caroline, MacDonald, Clare, Tabor, Dadirayi, Denning, Dawn, Roberts, Debbie, Adshead, Diane, Clarke, Gemma, Huntley, Heather, Pinder, Heather, Qasim, Irene, Merrison, Jane, King, Jill, Allison, Julie, Johal, Kam, Terry, Karen, Wood, Karine, Balmford, Kathryn, Barnes, Katie, Post, Katie, Bowden, Kelly-Marie, Edmunds, Kirsty, Whittle, Klaire, Peniket, Lara, Carnegie, Leann, Neale, Linda, Davey, Lisa, Bartlett, Liz, Smith, Louise, Clack, Lucy, Brown, Martina, McKenna, Naomi, Kay, Pam, Jacobs, Polly, Cutts, Rebecca, Pearse, Robert, Atkinson, Ruth, Barter, Sally, Mackie, Sally, Norris, Sam, Cook, Sandra, Elderfield, Sarah, Nzante, Sarah, Cronin, Sharon, Maslen, Sophie, Marchant, Stephanie, Wright, Stephanie, Keene, Sue, Smith, Sue, Cimelli, Suzie, Stone, Tracy, Joyce, Tricia, Le Marechal, Trudie, Kettle, Vicky, Osborne, Victoria, Cubiss, Wendy, Marsden, Wendy, Kowalczyk-Williams, Wioletta, and Bailey, Zoe

Subjects
Male, medicine.medical_specialty, General Practice, Psychological intervention, Blood Pressure, law.invention, Randomized controlled trial, law, Diabetes mellitus, Clinical endpoint, Humans, Medicine, Antihypertensive Agents, Aged, business.industry, Research, Self-Management, General Medicine, Blood Pressure Monitoring, Ambulatory, Middle Aged, medicine.disease, Telemedicine, United Kingdom, Confidence interval, Mean blood pressure, Blood pressure, Hypertension, Physical therapy, Female, Physical and Mental Health, business, Incremental cost-effectiveness ratio
Abstract

Objective The HOME BP (Home and Online Management and Evaluation of Blood Pressure) trial aimed to test a digital intervention for hypertension management in primary care by combining self-monitoring of blood pressure with guided self-management. Design Unmasked randomised controlled trial with automated ascertainment of primary endpoint. Setting 76 general practices in the United Kingdom. Participants 622 people with treated but poorly controlled hypertension (>140/90 mm Hg) and access to the internet. Interventions Participants were randomised by using a minimisation algorithm to self-monitoring of blood pressure with a digital intervention (305 participants) or usual care (routine hypertension care, with appointments and drug changes made at the discretion of the general practitioner; 317 participants). The digital intervention provided feedback of blood pressure results to patients and professionals with optional lifestyle advice and motivational support. Target blood pressure for hypertension, diabetes, and people aged 80 or older followed UK national guidelines. Main outcome measures The primary outcome was the difference in systolic blood pressure (mean of second and third readings) after one year, adjusted for baseline blood pressure, blood pressure target, age, and practice, with multiple imputation for missing values. Results After one year, data were available from 552 participants (88.6%) with imputation for the remaining 70 participants (11.4%). Mean blood pressure dropped from 151.7/86.4 to 138.4/80.2 mm Hg in the intervention group and from 151.6/85.3 to 141.8/79.8 mm Hg in the usual care group, giving a mean difference in systolic blood pressure of −3.4 mm Hg (95% confidence interval −6.1 to −0.8 mm Hg) and a mean difference in diastolic blood pressure of −0.5 mm Hg (−1.9 to 0.9 mm Hg). Results were comparable in the complete case analysis and adverse effects were similar between groups. Within trial costs showed an incremental cost effectiveness ratio of £11 ($15, €12; 95% confidence interval £6 to £29) per mm Hg reduction. Conclusions The HOME BP digital intervention for the management of hypertension by using self-monitored blood pressure led to better control of systolic blood pressure after one year than usual care, with low incremental costs. Implementation in primary care will require integration into clinical workflows and consideration of people who are digitally excluded. Trial registration ISRCTN13790648 .

Published
2020

19. Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers

Author

Muller, Ingrid, primary, Stuart, Beth, additional, Sach, Tracey, additional, Hooper, Julie, additional, Wilczynska, Sylvia, additional, Steele, Mary, additional, Greenwell, Kate, additional, Sivyer, Katy, additional, Yardley, Lucy, additional, Williams, Hywel C, additional, Chalmers, Joanne R, additional, Leighton, Paul, additional, Howells, Laura M, additional, Ridd, Matthew J, additional, Lawton, Sandra, additional, Griffiths, Gareth, additional, Nuttall, Jacqui, additional, Langan, Sinead M, additional, Roberts, Amanda, additional, Ahmed, Amina, additional, Kirk, Hayden, additional, Becque, Taeko, additional, Little, Paul, additional, Thomas, Kim S, additional, and Santer, Miriam, additional

Published
2021
Full Text
View/download PDF

20. Home and Online Management and Evaluation of Blood Pressure (HOME BP) using a digital intervention in poorly controlled hypertension: randomised controlled trial

Author

McManus, Richard J, primary, Little, Paul, additional, Stuart, Beth, additional, Morton, Katherine, additional, Raftery, James, additional, Kelly, Jo, additional, Bradbury, Katherine, additional, Zhang, Jin, additional, Zhu, Shihua, additional, Murray, Elizabeth, additional, May, Carl R, additional, Mair, Frances S, additional, Michie, Susan, additional, Smith, Peter, additional, Band, Rebecca, additional, Ogburn, Emma, additional, Allen, Julie, additional, Rice, Cathy, additional, Nuttall, Jacqui, additional, Williams, Bryan, additional, and Yardley, Lucy, additional

Published
2021
Full Text
View/download PDF

21. P013: MENOS4 trial: Nurses can be trained to effectively deliver CBT for menopausal hot flushes in women with breast cancer to reduce hot flush bother and improve quality of life

Author

Fenlon, Deborah, primary, Nuttall, Jacqui, additional, Day, Laura, additional, Maishman, Tom, additional, Griffiths, Gareth, additional, Turner, Lesley, additional, May, Carl, additional, Raftery, James, additional, Ellis, Mary, additional, Fields, Jo, additional, and Hunter, Myra, additional

Published
2020
Full Text
View/download PDF

22. Treatment of acute cough/lower respiratory tract infection by antibiotic class and associated outcomes: a 13 European country observational study in primary care

Author

Butler, Christopher C., Hood, Kerenza, Kelly, Mark J., Goossens, Herman, Verheij, Theo, Little, Paul, Melbye, Hasse, Torres, Antoni, Mölstad, Sigvard, Godycki-Cwirko, Maciek, Almirall, Jordi, Blasi, Francesco, Schaberg, Tom, Edwards, Peter, Rautakorpi, Ulla-Maija, Hupkova, Helena, Wood, Joseph, Nuttall, Jacqui, and Coenen, Samuel

Published
2010
Full Text
View/download PDF

27. Probiotics for Antibiotic-Associated Diarrhoea (PAAD): a prospective observational study of antibiotic-associated diarrhoea (including Clostridium difficile-associated diarrhoea) in care homes

Author

Hood, Kerenza, primary, Nuttall, Jacqui, additional, Gillespie, David, additional, Shepherd, Victoria, additional, Wood, Fiona, additional, Duncan, Donna, additional, Stanton, Helen, additional, Espinasse, Aude, additional, Wootton, Mandy, additional, Acharjya, Aruna, additional, Allen, Stephen, additional, Bayer, Antony, additional, Carter, Ben, additional, Cohen, David, additional, Francis, Nick, additional, Howe, Robin, additional, Mantzourani, Efi, additional, Thomas-Jones, Emma, additional, Toghill, Alun, additional, and Butler, Christopher C, additional

Published
2014
Full Text
View/download PDF

28. Treatment of acute cough/lower respiratory tract infection by antibiotic class and associated outcomes: a 13 European country observational study in primary care

Author

Butler, Christopher C, Kelly, Mark J, Goossens, Herman, Verheij, Theo, Little, Paul, Melbye, Hasse, Torres, Antoni, Mölstad, Sigvard, Godycki-Cwirko, Maciek, Almirall, Jordi, Blasi, Francesco, Schaberg, Tom, Edwards, Peter, Rautakorpi, Ulla-Maija, Hupkova, Helena, Wood, Joseph, Nuttall, Jacqui, Coenen, Samuel, Butler, Christopher C, Kelly, Mark J, Goossens, Herman, Verheij, Theo, Little, Paul, Melbye, Hasse, Torres, Antoni, Mölstad, Sigvard, Godycki-Cwirko, Maciek, Almirall, Jordi, Blasi, Francesco, Schaberg, Tom, Edwards, Peter, Rautakorpi, Ulla-Maija, Hupkova, Helena, Wood, Joseph, Nuttall, Jacqui, and Coenen, Samuel

Abstract

Acute cough/lower respiratory tract infection (LRTI) is one of the commonest reasons for consulting and antibiotic prescribing. There are theoretical reasons why treatment with particular antibiotic classes may aid recovery more than others, but empirical, pragmatic evidence is lacking. We investigated whether treatment with a particular antibiotic class (amoxicillin) was more strongly associated with symptom score resolution and time to patients reporting recovery than each of eight other antibiotic classes or no antibiotic treatment for acute cough/LRTI. Clinicians recorded history, examination findings, symptom severity and antibiotic treatment for 3402 patients in a 13 country prospective observational study of adults presenting in 14 primary care research networks with acute cough/LRTI. 2714 patients completed a symptom score daily for up to 28 days and recorded the day on which they felt recovered. A three-level autoregressive moving average model (1,1) model investigated logged daily symptom scores to analyse symptom resolution. A two-level survival model analysed time to reported recovery. Clinical presentation was controlled for using clinician-recorded symptoms, sputum colour, temperature, age, co-morbidities, smoking status and duration of illness prior to consultation. Compared with amoxicillin, no antibiotic class (and no antibiotic treatment) was associated with clinically relevant improved symptom resolution (all coefficients in the range -0.02 to 0.01 and all P values greater than 0.12). No antibiotic class (and no antibiotic treatment) was associated with faster time to recovery than amoxicillin. Treatment by antibiotic class was not associated with symptom resolution or time to recovery in adults presenting to primary care with acute cough/LRTI.

Published
2010
Full Text
View/download PDF

31. Are Patient Views about Antibiotics Related to Clinician Perceptions, Management and Outcome? A Multi-Country Study in Outpatients with Acute Cough.

Author

Coenen, Samuel, Francis, Nick, Kelly, Mark, Hood, Kerenza, Nuttall, Jacqui, Little, Paul, Verheij, Theo J. M., Melbye, Hasse, Goossens, Herman, and Butler, Christopher C.

Subjects
ANTIBIOTICS, HEALTH outcome assessment, DISEASE management, OUTPATIENT medical care, COUGH, PATIENT satisfaction, DRUG prescribing, DRUG efficacy, PATIENTS
Abstract

Background: Outpatients with acute cough who expect, hope for or ask for antibiotics may be more unwell, benefit more from antibiotic treatment, and be more satisfied with care when they are prescribed antibiotics. Clinicians may not accurately identify those patients. Objective: To explore whether patient views (expecting, hoping for or asking for antibiotics) are associated with illness presentation and resolution, whether patient views are accurately perceived by clinicians, and the association of all these factors with antibiotic prescribing and patient satisfaction with care. Methods: Prospective observational study of 3402 adult patients with acute cough presenting in 14 primary care networks. Correlations and associations tested with multilevel logistic regression and McNemar ‘s tests, and Cohen’s Kappa, positive agreement (PA) and negative agreement (NA) calculated as appropriate. Results: 1,213 (45.1%) patients expected, 1,093 (40.6%) hoped for, and 275 (10.2%) asked for antibiotics. Clinicians perceived 840 (31.3%) as wanting to be prescribed antibiotics (McNemar’s test, p<0.05). Their perception agreed modestly with the three patient views (Kappa’s = 0.29, 0.32 and 0.21, PA’s = 0.56, 0.56 and 0.33, NA’s = 0.72, 0.75 and 0.82, respectively). 1,464 (54.4%) patients were prescribed antibiotics. Illness presentation and resolution were similar for patients regardless their views. These associations were not modified by antibiotic treatment. Patient expectation and hope (OR:2.08, 95% CI:[1.48,2.93] and 2.48 [1.73,3.55], respectively), and clinician perception (12.18 [8.31,17.84]) were associated with antibiotic prescribing. 2,354 (92.6%) patients were satisfied. Only those hoping for antibiotics were less satisfied when antibiotics were not prescribed (0.39 [0.17,0.90]). Conclusion: Patient views about antibiotic treatment were not useful for identifying those who will benefit from antibiotics. Clinician perceptions did not match with patient views, but particularly influenced antibiotic prescribing. Patients were generally satisfied with care, but those hoping for but not prescribed antibiotics were less satisfied. Clinicians need to more effectively elicit and address patient views about antibiotics. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results