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3. Genome Sequence of the Chestnut Blight Fungus Cryphonectria parasitica EP155: A Fundamental Resource for an Archetypical Invasive Plant Pathogen.

Author

Crouch, Jo Anne, Dawe, Angus, Aerts, Andrea, Barry, Kerrie, Churchill, Alice CL, Grimwood, Jane, Hillman, Bradley I, Milgroom, Michael G, Pangilinan, Jasmyn, Smith, Myron, Salamov, Asaf, Schmutz, Jeremy, Yadav, Jagjit S, Grigoriev, Igor V, and Nuss, Donald L

Subjects
Ascomycota, Fagaceae, Plant Diseases, North America, Fungal Viruses, chestnut blight, forest pathology, mycology, mycoviruses, transposable elements, vegetative incompatibility, Plant Biology & Botany, Microbiology, Plant Biology, Crop and Pasture Production
Abstract

Cryphonectria parasitica is the causal agent of chestnut blight, a fungal disease that almost entirely eliminated mature American chestnut from North America over a 50-year period. Here, we formally report the genome of C. parasitica EP155 using a Sanger shotgun sequencing approach. After finishing and integration with simple-sequence repeat markers, the assembly was 43.8 Mb in 26 scaffolds (L50 = 5; N50 = 4.0Mb). Eight chromosomes are predicted: five scaffolds have two telomeres and six scaffolds have one telomere sequence. In total, 11,609 gene models were predicted, of which 85% show similarities to other proteins. This genome resource has already increased the utility of a fundamental plant pathogen experimental system through new understanding of the fungal vegetative incompatibility system, with significant implications for enhancing mycovirus-based biological control.

Published
2020

7. Multicenter study of pectus excavatum, final report: complications, static/exercise pulmonary function, and anatomic outcomes.

Author

Kelly, Robert E, Mellins, Robert B, Shamberger, Robert C, Mitchell, Karen K, Lawson, M Louise, Oldham, Keith T, Azizkhan, Richard G, Hebra, Andre V, Nuss, Donald, Goretsky, Michael J, Sharp, Ronald J, Holcomb, George W, Shim, Walton KT, Megison, Stephen M, Moss, R Lawrence, Fecteau, Annie H, Colombani, Paul M, Cooper, Dan, Bagley, Traci, Quinn, Amy, Moskowitz, Alan B, and Paulson, James F

Subjects
Humans, Funnel Chest, Postoperative Complications, Tomography, X-Ray Computed, Exercise Test, Respiratory Function Tests, Treatment Outcome, Orthopedic Procedures, Follow-Up Studies, Prospective Studies, Body Image, Psychological Tests, Adolescent, Child, Female, Male, CO(2) production, FEV(1), FVC, HR, O(2) consumption, V(CO(2)), V(O(2)), VE, WR, forced expiratory volume in 1 second, forced vital capacity, heart rate, ventilation, work rate, Tomography, X-Ray Computed, Surgery, Clinical Sciences
Abstract

BackgroundA multicenter study of pectus excavatum was described previously. This report presents our final results.Study designPatients treated surgically at 11 centers were followed prospectively. Each underwent a preoperative evaluation with CT scan, pulmonary function tests, and body image survey. Data were collected about associated conditions, complications, and perioperative pain. One year after treatment, patients underwent repeat chest CT scan, pulmonary function tests, and body image survey. A subset of 50 underwent exercise pulmonary function testing.ResultsOf 327 patients, 284 underwent Nuss procedure and 43 underwent open procedure without mortality. Of 182 patients with complete follow-up (56%), 18% had late complications, similarly distributed, including substernal bar displacement in 7% and wound infection in 2%. Mean initial CT scan index of 4.4 improved to 3.0 post operation (severe >3.2, normal = 2.5). Computed tomography index improved at the deepest point (xiphoid) and also upper and middle sternum. Pulmonary function tests improved (forced vital capacity from 88% to 93%, forced expiratory volume in 1 second from 87% to 90%, and total lung capacity from 94% to 100% of predicted (p < 0.001 for each). VO2 max during peak exercise increased by 10.1% (p = 0.015) and O2 pulse by 19% (p = 0.007) in 20 subjects who completed both pre- and postoperative exercise tests.ConclusionsThere is significant improvement in lung function at rest and in VO2 max and O2 pulse after surgical correction of pectus excavatum, with CT index >3.2. Operative correction significantly reduces CT index and markedly improves the shape of the entire chest, and can be performed safely in a variety of centers.

Published
2013

20. Pectus Excavatum

Author

Kelly, Robert E., Nuss, Donald, Parikh, Dakshesh H., editor, Crabbe, David C. G., editor, Auldist, Alexander W., editor, and Rothenberg, Steven S., editor

Published
2009
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32. Increasing Severity of Pectus Excavatum is Associated with Reduced Pulmonary Function

Author

Lawson, M. Louise, Mellins, Robert B., Paulson, James F., Shamberger, Robert C., Oldham, Keith, Azizkhan, Richard G., Hebra, Andre V., Nuss, Donald, Goretsky, Michael J., Sharp, Ronald J., Holcomb, George W., III, Shim, Walton K.T., Megison, Stephen M., Moss, R. Lawrence, Fecteau, Annie H., Colombani, Paul M., Moskowitz, Alan B., Hill, Joshua, and Kelly, Robert E., Jr.

Published
2011
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