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28 results on '"Nusrat, Sanober"'

2. PROMISE: a real-world clinical-genomic database to address knowledge gaps in prostate cancer

Author

Koshkin, Vadim S., Patel, Vaibhav G., Ali, Alicia, Bilen, Mehmet A., Ravindranathan, Deepak, Park, Joseph J., Kellezi, Olesia, Cieslik, Marcin, Shaya, Justin, Cabal, Angelo, Brown, Landon, Labriola, Matthew, Graham, Laura S., Pritchard, Colin, Tripathi, Abhishek, Nusrat, Sanober, Barata, Pedro, Jang, Albert, Chen, Shuang R., Garje, Rohan, Acharya, Luna, Hwang, Clara, Pilling, Amanda, Oh, William, Jun, Tomi, Natesan, Divya, Nguyen, Chris, Kilari, Deepak, Pierro, Michael, Thapa, Bicky, Cackowski, Frank, Mack, Alleda, Heath, Elisabeth, Marshall, Catherine H., Tagawa, Scott T., Halabi, Susan, Schweizer, Michael T., Armstrong, Andrew, Dorff, Tanya, Alva, Ajjai, and McKay, Rana

Published
2022
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3. Thrombotic Microangiopathy After Hematopoietic Stem Cell and Solid Organ Transplantation: A Review for Intensive Care Physicians.

Author

Nusrat, Sanober, Davis, Hugh, MacDougall, Kira, George, James N., Nakamura, Ryotaro, and Borogovac, Azra

Subjects
*HEMATOPOIETIC stem cells, *INTENSIVE care units, *PRIMARY health care, *THROMBOTIC microangiopathies, *RITUXIMAB, *TRANSPLANTATION of organs, tissues, etc.
Abstract

Intensive care physicians may assume the primary care of patients with transplant-associated thrombotic microangiopathy (TA-TMA), an uncommon but potentially critical complication of hematopoietic stem cell transplants (HSCTs) and solid organ transplants. TA-TMA can have a dramatic presentation with multiple organ dysfunction syndrome (MODS) associated with high morbidity and mortality. The typical presenting clinical features are hemolytic anemia, thrombocytopenia, refractory hypertension, proteinuria and worsening renal failure. Intestinal involvement, with abdominal pain, nausea and vomiting, gastrointestinal bleeding, and ascites are also common. Cardiopulmonary involvement may develop from various causes including pulmonary arteriolar hypertension, pleural and pericardial effusions, and diffuse alveolar hemorrhage. Due to other often concurrent complications after HSCT, early diagnosis and effective management of TA-TMA may be challenging. Close collaboration between ICU and transplant physicians, along with other relevant specialists, is needed to best manage these patients. There are currently no approved therapies for the treatment of TA-TMA. Plasma exchange and rituximab are not recommended unless circulating factor H (CFH) antibodies or thrombotic thrombocytopenic purpura (TTP; ADAMTS activity < 10%) are diagnosed or highly suspected. The role of the complement pathway activation in the pathophysiology of TA-TMA has led to the successful use of targeted complement inhibitors, such as eculizumab. However, the relatively larger studies using eculizumab have been mostly conducted in the pediatric population with limited data on the adult population. This review is focused on the role of intensive care physicians to emphasize the clinical approach to patients with suspected TA-TMA and to discuss diagnosis and treatment strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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11. PROMISE: a real-world clinical-genomic database to address knowledge gaps in prostate cancer

Author

Koshkin, Vadim S., primary, Patel, Vaibhav G., additional, Ali, Alicia, additional, Bilen, Mehmet A., additional, Ravindranathan, Deepak, additional, Park, Joseph J., additional, Kellezi, Olesia, additional, Cieslik, Marcin, additional, Shaya, Justin, additional, Cabal, Angelo, additional, Brown, Landon, additional, Labriola, Matthew, additional, Graham, Laura S., additional, Pritchard, Colin, additional, Tripathi, Abhishek, additional, Nusrat, Sanober, additional, Barata, Pedro, additional, Jang, Albert, additional, Chen, Shuang R., additional, Garje, Rohan, additional, Acharya, Luna, additional, Hwang, Clara, additional, Pilling, Amanda, additional, Oh, William, additional, Jun, Tomi, additional, Natesan, Divya, additional, Nguyen, Chris, additional, Kilari, Deepak, additional, Pierro, Michael, additional, Thapa, Bicky, additional, Cackowski, Frank, additional, Mack, Alleda, additional, Heath, Elisabeth, additional, Marshall, Catherine H., additional, Tagawa, Scott T., additional, Halabi, Susan, additional, Schweizer, Michael T., additional, Armstrong, Andrew, additional, Dorff, Tanya, additional, Alva, Ajjai, additional, and McKay, Rana, additional

Published
2021
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15. A Rare Presentation of Neutrophilic Eccrine Hidradenitis in the Management of Acute Myeloid Leukaemia: A Case Report

Author

Sai Sridhar Boddupalli, Syed Talal, Nusrat Sanober, Jennifer Holter, Shannie Frisbie, Susanna Varkey Ulahannan, Midhun Malla, and Adam S. Asch

Subjects
Cancer Research, medicine.medical_specialty, Oncology, business.industry, Neutrophilic eccrine hidradenitis, medicine, Presentation (obstetrics), Myeloid leukaemia, medicine.disease, business, Dermatology
Published
2018

24. Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review

Author

Nusrat, Sanober, Gulick, Elsie, Levinthal, David, and Bielefeldt, Klaus

Subjects
Article Subject
Abstract

Constipation and fecal incontinence are common in patients with neuromuscular diseases. Despite their high prevalence and potential impact on overall quality of life, few studies have addressed anorectal dysfunction in patients with multiple sclerosis (MS). The goal of this paper is to define the prevalence, pathophysiology, impact, and potential treatment of constipation and incontinence in MS patients. Methods. The PubMed database was searched for English language publications between January 1973 and December 2011. Articles were reviewed to assess the definition of the study population, duration, type and severity of MS, sex distribution, prevalence, impact, results of physiologic testing, and treatments. Results. The reported prevalence of constipation and fecal incontinence ranged around 40%. Anorectal dysfunction significantly affected patients with nearly 1 in 6 patients limiting social activities or even quitting work due to symptoms. Caregivers listed toileting as a common and significant burden. The only randomized controlled trial showed a marginal improvement of constipation with abdominal massage. All other reports lacked control interventions and only demonstrated improvement in individuals with milder symptoms. Conclusion. Anorectal dysfunction is a common manifestation in MS that significantly affects quality of life. Therapies are at best moderately effective and often cumbersome, highlighting the need for simple and more helpful interventions.

Published
2012
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26. Reflux and sex

Author

Nusrat, Salman, primary, Nusrat, Sanober, additional, and Bielefeldt, Klaus, additional

Published
2012
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28. Reflux and sex: what drives testing, what drives treatment?

Author

Nusrat S, Nusrat S, and Bielefeldt K

Subjects
Barrett Esophagus epidemiology, Esophageal pH Monitoring statistics & numerical data, Esophagitis, Peptic epidemiology, Female, Fundoplication statistics & numerical data, Gastroesophageal Reflux epidemiology, Hospitalization statistics & numerical data, Humans, Male, Sex Distribution, Sex Factors, United States epidemiology, Esophagoscopy statistics & numerical data, Gastroesophageal Reflux diagnosis, Gastroesophageal Reflux surgery
Abstract

Gastroesophageal reflux (GER) affects ∼10-20% of American adults. Although symptoms are equally common in men and women, we hypothesized that sex influences diagnostic and therapeutic approaches in patients with GER. PubMed database between 1997 and October 2011 was searched for English language studies describing symptoms, consultative visits, endoscopic findings, use and results of ambulatory pH study, and surgical therapy for GER. Using data from Nationwide Inpatient Sample, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality, we determined the sex distribution for admissions and reflux surgery between 1997 and 2008. Studies on symptoms or consultative visits did not show sex-specific differences. Even though women are less likely to have esophagitis or Barrett's esophagus, endoscopic studies enrolled as many women as men, and women were more likely to undergo ambulatory pH studies with a female predominance in studies from the US. Surgical GER treatment is more commonly performed in men. However, studies from the US showed an equal sex distribution, with Nationwide Inpatient Sample data demonstrating an increase in women who accounted for 63% of the annual fundoplications in 2008. Despite less common or severe mucosal disease, women are more likely to undergo invasive diagnostic testing. In the US, women are also more likely to undergo antireflux surgery. These results suggest that healthcare-seeking behavior and socioeconomic factors rather than the biology of disease influence the clinical approaches to reflux disease.

Published
2012
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