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• COVID-19 vaccination prevents infection and hospitalizations in pregnant patients. • COVID- 19 vaccine is protective against neonatal COVID-19 I.C.U. admissions. • Canada showed significant decrease in neonatal ICU admissions after vaccination of mothers. • There is a significant decrease in preterm births when patients were vaccinated in the third trimester. • There was a significant decrease noted in COVID-19 infection after receiving the vaccination in all locations except England. To evaluate the safety and efficacy of COVID-19 vaccines in pregnant women performing an updated meta-analysis. We searched PubMed, Cochrane Central, and SCOPUS from inception to March 2022. Outcomes of interest were incidence of adverse maternal, fetal and neonatal consequences pertaining to safety of the vaccines. Secondarily, we analyzed the number of SARS-CoV-2 infections, hospitalization for COVID-19, and admission to the I.C.U. for COVID-19 assessing the effectiveness of vaccines. Results were pooled using a random effects model. Ten observational studies (n=326,499) analyzing pregnant women were included. Our results suggest that COVID-19 vaccination prevents infection (OR: 0.56, 95% CI: 0.47, 0.67; P = <0.00001) and related hospitalizations (OR: 0.50, 95% CI: 0.31, 0.82; P = 0.006) effectively. It was also observed that vaccination does not change adverse outcomes in pregnancy, namely preeclampsia or eclampsia, stroke (four weeks of delivery), meconium-stained amniotic fluid, spontaneous vaginal delivery, operative vaginal delivery, cesarean delivery, postpartum hemorrhage, and blood transfusions. Furthermore, the vaccine was observed to be protective against neonatal COVID-19 I.C.U. admissions (OR: 0.85; 95% CI: 0.81, 0.90; P = <0.00001). Our pooled analysis suggests that the COVID-19 vaccination in pregnant women prevents infection effectively and has no adverse outcomes. Future large-scale trials in a randomized fashion are needed to confirm our results. [ABSTRACT FROM AUTHOR]

Objective: To assess knowledge among pregnant women regarding neonatal danger signs and to evaluate their healthcare seeking behaviour., Methods: The cross-sectional study was conducted at Civil Hospital, Karachi, from February to April 2018, and comprised pregnant females presenting to the hospital. They were interviewed through a structured questionnaire. Participants' knowledge regarding 12 neonatal danger signs was assessed. Those who could identify 3 or more such signs were considered to have a good knowledge. Data was analysed using SPSS 23., Results: There were 468 subjects with a mean age of 25.17±5.18 years. Of the total, 416(88.9%) women were aged 18-35 years. Overall, 72(15%) subjects had good knowledge, while 366(78%) could identify at least one danger sign. Also, 318(82%) participants preferred visiting a hospital / clinic to seek healthcare., Conclusions: There was a severe lack of knowledge among pregnant women regarding neonatal danger signs. However, most participants realised the necessity of taking their neonate to a hospital / clinic for proper healthcare.