44 results on '"Nushida, H."'
Search Results
2. Association between a functional polymorphism in the renin-angiotensin system and completed suicide
- Author
-
Hishimoto, A., Shirakawa, O., Nishiguchi, N., Hashimoto, T., Yanagi, M., Nushida, H., Ueno, Y., and Maeda, K.
- Published
- 2006
- Full Text
- View/download PDF
3. Tryptophan hydroxylase immunoreactivity is altered by the genetic variation in postmortem brain samples of both suicide victims and controls
- Author
-
Ono, H, Shirakawa, O, Kitamura, N, Hashimoto, T, Nishiguchi, N, Nishimura, A, Nushida, H, Ueno, Y, and Maeda, K
- Published
- 2002
- Full Text
- View/download PDF
4. Alcohol-induced Membrane Damage This work was supported in part by a Grant-in-Aid for Scientific Research from Japan Society for the Promotion of Science. We thank The British Council and the Daiwa Anglo-Japanese Foundation for funding the collaboration between the UK and Japan. We also thank Dr M. Asano, Dr R. Kudo, Dr T. Fujita, Dr K. Ishii, and Dr K. Ariyoshi (Kobe University) for help and discussion.
- Author
-
Adachi, J, primary, Nushida, H, additional, Ueno, Y, additional, and Preedy, VR, additional
- Published
- 2005
- Full Text
- View/download PDF
5. First Official Disaster Relief Activities of the Japan DMORT Association in Collaboration with Police Department in the 2016 Kumamoto Earthquakes, Japan
- Author
-
Kuboyama, Kazutoshi, primary, Asada, Tsuneo, additional, Kohno, Tokmoko, additional, Akitomi, S, additional, Kubota, C, additional, Kurokawa, Kayoko, additional, Murakami, Noriko, additional, Nagasaki, Yasushi, additional, Nushida, H, additional, Yamazaki, Tatsue, additional, and Yoshinaga, Kazumasa, additional
- Published
- 2017
- Full Text
- View/download PDF
6. Virtuelle Endoskopie des Herzens post mortem – Erste Ergebnisse
- Author
-
Scharf, LB, primary, Nushida, H, additional, Heinemann, A, additional, and Vogel, H, additional
- Published
- 2010
- Full Text
- View/download PDF
7. Differences in characteristics between suicide victims who left notes or not
- Author
-
KUWABARA, H, primary, SHIOIRI, T, additional, NISHIMURA, A, additional, ABE, R, additional, NUSHIDA, H, additional, UENO, Y, additional, AKAZAWA, K, additional, and SOMEYA, T, additional
- Published
- 2006
- Full Text
- View/download PDF
8. 95 - Alcohol-induced Membrane Damage
- Author
-
Adachi, J, Nushida, H, Ueno, Y, and Preedy, V.R.
- Published
- 2004
- Full Text
- View/download PDF
9. Serotonin 2A receptor gene polymorphism is not associated with completed suicide
- Author
-
Ono, H., Shirakawa, O., Nishiguchi, N., Nishimura, A., Nushida, H., Ueno, Y., and Maeda, K.
- Published
- 2001
- Full Text
- View/download PDF
10. An unusual case of suicide by stabbing with a falling weighted dagger
- Author
-
Ueno, Y., Asano, M., Nushida, H., Adachi, J., and Tatsuno, Y.
- Published
- 1999
- Full Text
- View/download PDF
11. Changes in choice of method and lethality between last attempted and completed suicides: how did suicide attempters carry out their desire?
- Author
-
Nishimura, A., Shioiri, T., Nushida, H., Ueno, Y., Ushiyama, I., Tanegashima, A., Someya, T., and Nishi, K.
- Published
- 1999
- Full Text
- View/download PDF
12. Answer to the letter to the editor by J. Finsterer concerning "A case of fatal multi-organ inflammation following COVID-19 vaccination" by H. Nushida et al. (https://doi.org/10.1016/j.legalmed.2023.102244.).
- Author
-
Nushida H, Ito A, Kurata H, and Nishimura A
- Subjects
- Humans, Vaccination, COVID-19 Vaccines adverse effects, COVID-19
- Abstract
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
- Published
- 2023
- Full Text
- View/download PDF
13. A case of fatal multi-organ inflammation following COVID-19 vaccination.
- Author
-
Nushida H, Ito A, Kurata H, Umemoto H, Tokunaga I, Iseki H, and Nishimura A
- Subjects
- Adolescent, Female, Humans, Death, Sudden etiology, Inflammation complications, Vaccination adverse effects, Atrial Fibrillation complications, COVID-19, COVID-19 Vaccines adverse effects, Myocarditis complications
- Abstract
A 14-year-old Japanese girl died unexpectedly 2 days after receiving the third dose of the BNT1262b2 mRNA COVID-19 vaccine. Autopsy findings showed congestive edema of the lungs, T-cell lymphocytic and macrophage infiltration in the lungs, pericardium, and myocardium of the left atria and left ventricle, liver, kidneys, stomach, duodenum, bladder, and diaphragm. Since there was no preceding infection, allergy, or drug toxicity exposure, the patient was diagnosed with post-vaccination pneumonia, myopericarditis, hepatitis, nephritis, gastroenteritis, cystitis, and myositis. Although neither type of inflammation is fatal by itself, arrhythmia is reported to be the most common cause of death in patients with atrial myopericarditis. In the present case, arrhythmia of atrial origin was assumed as the cause of cardiac failure and death. In sudden post-vaccination deaths, aggressive autopsy systemic search and histological examination involving extensive sectioning of the heart, including the atrium, are indispensable., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
14. A case of complete decapitation in suicidal hanging : the mechanism and condition of decapitation.
- Author
-
Ito A, Nushida H, Kurata H, Umemoto H, Iseki H, Tokunaga I, and Nishimura A
- Subjects
- Male, Humans, Suicidal Ideation, Cervical Vertebrae, Skin, Decapitation, Suicide
- Abstract
Complete decapitation due to suicide by hanging is rare. We report the case of a decapitated man who was found in the sea near an estuary. A polyethylene rope was tied to the handrail of the bridge across a strait near the site of the body. The rope was 12 mm in diameter and 19 m in length from the handrail. It ended with a slip knot noose, and skin and mustache-like hair fragments were attached to it. The decapitated head was not found. The deceased weighed 82 kg and was 152 cm long without the head. The autopsy revealed coarse abrasions and intramuscular hemorrhage around the severed edge. The third cervical spine was not fractured. We reviewed the literature and suggested the conditions of body weight, fall height, rope diameter, and number of rolls in cases of decapitation by hanging. We calculated the hanging decapitation index (HDI) as the fall height (m) multiplied by the body weight (kg), divided by the rope diameter (mm), divided by the number of rolls ; and discussed the differences between complete and incomplete decapitation cases. J. Med. Invest. 70 : 290-293, February, 2023.
- Published
- 2023
- Full Text
- View/download PDF
15. Fatal pneumoperitoneum following endoscopic retrograde cholangiopancreatography confirmed by post-mortem computed tomography.
- Author
-
Schröder AS, Heinemann A, Nushida H, and Sperhake JP
- Subjects
- Aged, 80 and over, Duodenum injuries, Duodenum pathology, Fatal Outcome, Female, Humans, Intestinal Perforation complications, Intestinal Perforation pathology, Multidetector Computed Tomography, Respiratory Insufficiency etiology, Cholangiopancreatography, Endoscopic Retrograde adverse effects, Pneumoperitoneum diagnostic imaging, Pneumoperitoneum etiology
- Published
- 2015
- Full Text
- View/download PDF
16. Assisted suicide and killing of a household pet: pre-autopsy post-mortem imaging of a victim and a dog.
- Author
-
Hasegawa I, Gehl A, Nushida H, and Püschel K
- Subjects
- Abdominal Neoplasms diagnostic imaging, Aged, Animals, Autopsy, Cause of Death, Dogs, Fatal Outcome, Female, Forensic Ballistics, Forensic Pathology methods, Head Injuries, Penetrating diagnostic imaging, Humans, Male, Middle Aged, Spouses, Thoracic Injuries pathology, Tomography, X-Ray Computed, Wounds, Gunshot diagnostic imaging, Abdominal Neoplasms pathology, Head Injuries, Penetrating pathology, Suicide, Assisted, Suicide, Attempted, Wounds, Gunshot pathology
- Published
- 2014
- Full Text
- View/download PDF
17. Determining falling patterns by estimation of horizontal distance and height.
- Author
-
Yanagida Y, Maeda M, Nushida H, Asano M, and Ueno Y
- Subjects
- Female, Forensic Medicine, Humans, Imaging, Three-Dimensional, Male, Models, Biological, Video Recording, Young Adult, Accidental Falls, Biophysical Phenomena
- Abstract
Whether by accident or foul play virtually thousands of fall-related fatalities occur each year. While a number of past studies addressed the relationship between falls, injury, and death, only a small fraction sought to establish an objective index geared specifically towards determining the cause of a particular fall. The primary objective in the present study was to determine the range of attainable horizontal distances in various forms of active and passive falling patterns. The secondary objective involved the capturing of physical motions at the point of impact via 3D motion analyses in order to identify the defining physical characteristics of a particular form of fall. The introduction of live test subjects to these series of experiments added the advent of fear and other psychological factors to the study which are crucial in simulating real-life cases. To corroborate this point, five subjects (three male and two female) expressed their wishes to withdraw from the study, attributing their decision to feeling an inherent danger and fear of the physical aspects of the present study. The ten subjects were made to fall from a height of 3.65 m under 13 conditions of various natures. Footage of the subjects falling was captured on two high-speed video cameras which markedly improved the calculation of 3D coordinates along the subjects' flight path. After extensive calculations, we were successful in determining the maximum attainable horizontal distances in passive falling patterns. Additionally, we found that force applied to the abdominal area results in shorter horizontal distances in comparison to falls where force is directly applied to the posterior side of the body.
- Published
- 2011
- Full Text
- View/download PDF
18. [Resident training program of coroner's office and trauma quality assurance in Los Angeles County, California, USA].
- Author
-
Nushida H
- Subjects
- Cause of Death, Humans, Los Angeles, Quality Assurance, Health Care, Coroners and Medical Examiners education, Internship and Residency
- Abstract
The author attended a practical training program at the Los Angeles County Coroner's Office for 2 weeks in June 2008. The systems of investigating the cause of death in the USA are not unified because every state has its own laws and systems, with Los Angeles County having a mixed system of Coroner and Medical Examiner. This report is presented to introduce the training course for medical residents at the Institute of LA. To begin, a tour through the office was provided. All residents then underwent a mask-fit-test in order to prevent infections. A conference to present cases for the day was held each morning, as well as lectures once or twice per week. The whole staff instructed the trainees with care, not only in the Institute but also at the death scene and the court. Additionally, the author also attended the LAC + USC Medical Center Combined Trauma Death Review Committee as an observer. This committee is very important for trauma quality assurance. The report of the coroner's autopsy is handed to the committee and the chairperson, a coroner, assesses the results of the emergency medical treatment. This greatly improves the quality of emergency medicine and reduces the number of preventable deaths.
- Published
- 2010
19. Influence on the suicide rate two years after a devastating disaster: a report from the 1995 Great Hanshin-Awaji Earthquake.
- Author
-
Nishio A, Akazawa K, Shibuya F, Abe R, Nushida H, Ueno Y, Nishimura A, and Shioiri T
- Subjects
- Adult, Age Factors, Aged, Female, Humans, Japan, Male, Middle Aged, Regression Analysis, Risk, Sex Factors, Young Adult, Earthquakes, Suicide statistics & numerical data
- Abstract
Aims: The relationship between suicide and disaster is an important problem but it's not clear. We conducted this study to determine whether a natural disaster affects suicide rates., Methods: We collected data on suicides during the 84 months before and the 60 months after the earthquake and compared the suicide rate in Kobe to that in Japan as a whole. We also examined what groups were significantly affected., Results: Compared with Japan as a whole, the suicide rates in Kobe significantly decreased in the 2 years after the earthquake., Conclusions: An influence on suicide rate after the disaster clearly appeared in middle-aged men.
- Published
- 2009
- Full Text
- View/download PDF
20. Lipid hydroperoxides in human plasma after ethanol consumption.
- Author
-
Asano M, Nushida H, Adachi J, Nagasaki Y, Nakagawa K, Kuse A, and Ueno Y
- Subjects
- Adult, Aldehyde Dehydrogenase genetics, Aldehyde Dehydrogenase, Mitochondrial, Central Nervous System Depressants blood, Cholesterol analogs & derivatives, Cholesterol blood, Ethanol blood, Female, Forensic Toxicology, Genotype, Humans, Male, Alcohol Drinking blood, Lipid Peroxides blood
- Abstract
Oxidative stress contributes to the pathogenesis of alcoholic liver disease. The purpose of this study is to estimate the amount of oxidative stress that is present when healthy humans consume moderate amounts of ethanol. Blood was collected from healthy volunteers before, 1 h, and 3 h after drinking 400 ml of Japanese rice wine at the rate of 100 ml per 5 min. The aldehyde dehydrogenase 2 genotype and the concentrations of blood ethanol, total lipid hydroperoxides (LOOH), and cholesterol hydroperoxides were determined. The plasma LOOH was found to have significantly increased 1h after drinking. Cholesterol hydroperoxides were not detected in plasma, either before or after drinking. There was no relationship between the LOOH and the ethanol concentration. We showed that one-shot of moderate ethanol consumption temporarily increases the plasma LOOH in healthy volunteers but excessive plasma LOOH compounds were eliminated within a short time.
- Published
- 2009
- Full Text
- View/download PDF
21. Suicide by a circular saw.
- Author
-
Asano M, Nushida H, Nagasaki Y, and Ueno Y
- Subjects
- Adult, Carotid Artery Injuries etiology, Carotid Artery Injuries pathology, Cervical Vertebrae injuries, Cervical Vertebrae pathology, Depression psychology, Female, Forensic Pathology, Humans, Jugular Veins pathology, Neck Injuries etiology, Wounds, Penetrating etiology, Neck Injuries pathology, Suicide, Wounds, Penetrating pathology
- Abstract
The case of a suicide of a 32-year-old female using an electric circular saw is herein described. The decedent was suffering from depression and was found dead in her room. Beside her right hand was lying a circular saw, which was not running. The autopsy revealed a large gaping wound measuring 15.5 cm in length on the right side of her neck. The right external carotid artery, the right internal jugular vein, and the right internal carotid artery were cut and the injury reached to the cervical vertebra. Therefore, the cause of death was exsanguination. An individual who commits suicide with an electric saw, such as a chain saw, band saw, and circular saw is rare; in particular females rarely select this method as the means of suicide. However, we herein report the case of a female patient with a psychiatric disease who successfully committed suicide with a circular saw.
- Published
- 2008
- Full Text
- View/download PDF
22. Rupture of a jejunal artery aneurysm.
- Author
-
Asano M, Nushida H, Nagasaki Y, Tatsuno Y, and Ueno Y
- Subjects
- Abdominal Pain etiology, Aged, Contrast Media, Fatal Outcome, Forensic Pathology, Humans, Jejunum pathology, Male, Multiple Organ Failure etiology, Shock etiology, Violence, Aneurysm, Ruptured pathology, Jejunum blood supply, Mesenteric Artery, Superior injuries, Mesenteric Artery, Superior pathology
- Abstract
Aneurysm of the superior mesenteric artery or its branches is rare. We herein present a case of a ruptured aneurysm of the jejunal artery, a branch of the superior mesenteric artery, and we also review 19 cases of jejunal artery aneurysm reported in the English literature. A 66-year-old male who had received a fist blow to the face presented in the emergency ward of his local hospital. His physical examination was unremarkable and he went back home after treatment of his facial wound. Two hours later he again visited the hospital, this time for severe abdominal pain, and he was hospitalized for suspicion of an intraperitoneal hemorrhage. Selective arteriography of the superior mesenteric artery revealed a ruptured aneurysm in the first branch of the jejunal artery. An emergency laparotomy was performed, but the patient died 29h after the injury. Because there was no evidence of any trauma to the abdomen, we concluded that the cause of death was exsanguination due to a ruptured aneurysm, and was not directly related to the earlier trauma. This case is considered to be of medico-legal interest regarding whether the rupture resulted from a natural disease or was due to an assault.
- Published
- 2008
- Full Text
- View/download PDF
23. Association of alpha2A-adrenergic receptor gene polymorphism with susceptibility to suicide in Japanese females.
- Author
-
Fukutake M, Hishimoto A, Nishiguchi N, Nushida H, Ueno Y, Shirakawa O, and Maeda K
- Subjects
- Adult, Alleles, Amino Acid Substitution, Case-Control Studies, Female, Gene Frequency, Genotype, Haplotypes, Humans, Japan epidemiology, Middle Aged, Polymorphism, Single Nucleotide, Reverse Transcriptase Polymerase Chain Reaction, Sex Characteristics, Polymorphism, Genetic genetics, Receptors, Adrenergic, alpha-2 genetics, Suicide statistics & numerical data
- Abstract
Objectives: It has been suggested that noradrenergic system abnormalities are involved in suicide. Postmortem brain studies have shown that molecular and functional alterations in alpha2A-adrenergic receptor-induced signal transduction are associated with suicide and depression. Recently, a single nucleotide polymorphism (SNP) within a coding region of the alpha2A-adrenergic receptor gene (ADRA2A), which results in an Asn-to-Lys change at amino acid 251 (N251K), has been implicated in susceptibility to suicide in Caucasians. The aim of our study is to determine whether genetic variants of the ADRA2A gene are also associated with suicide in a Japanese population., Methods: Three SNPs, C-1291G, N251K and rs3750625C/A, and one insertion/deletion polymorphism in the ADRA2A gene were genotyped in 184 completed suicides and 221 control subjects with the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method., Results: Neither variation of the N251K SNP nor the insertion/deletion polymorphism was found in our Japanese samples. The C-1291G SNP in the promoter region was found to be significantly associated with suicide in females (P=0.043 and 0.013 for genotypic and allelic comparisons, respectively). One of the common haplotypes, CC of C-1291G and rs3750625C/A, was also associated with suicide in females (P=0.015). These associations were also significant in the female violent suicide victims (P=0.009 and 0.009 for allelic and CC haplotypic comparisons, respectively). Although the significance was nominal, it was maintained even after correction for multiple comparisons. By contrast, neither of these two SNPs showed any association with violent and/or non-violent suicide in males., Conclusion: Our results raise the possibility that promoter genetic variation in the ADRA2A gene is associated with either suicide or violent suicide in females.
- Published
- 2008
- Full Text
- View/download PDF
24. Association of RGS2 gene polymorphisms with suicide and increased RGS2 immunoreactivity in the postmortem brain of suicide victims.
- Author
-
Cui H, Nishiguchi N, Ivleva E, Yanagi M, Fukutake M, Nushida H, Ueno Y, Kitamura N, Maeda K, and Shirakawa O
- Subjects
- Adult, Aged, Case-Control Studies, Chi-Square Distribution, DNA Mutational Analysis, Female, Gene Frequency, Genotype, Humans, Japan epidemiology, Ketanserin pharmacokinetics, Male, Middle Aged, Postmortem Changes, Protein Binding drug effects, Serotonin Antagonists pharmacokinetics, Brain metabolism, Polymorphism, Genetic genetics, RGS Proteins genetics, RGS Proteins metabolism, Suicide statistics & numerical data
- Abstract
Regulators of G-protein signaling are a family of proteins that negatively regulate the intracellular signaling of G protein-coupled receptors, such as the serotonin receptor. Recent studies have suggested that one of these proteins, the regulator of G-protein signaling 2 (RGS2), plays an important part in anxiety and/or aggressive behavior. To explore the involvement of the RGS2 gene in the vulnerability to suicide, we screened Japanese suicide victims for sequence variations in the RGS2 gene and carried out an association study of RGS2 gene polymorphisms with suicide victims. In the eight identified polymorphisms that were identified by mutation screening, we genotyped four common single-nucleotide polymorphisms (SNPs) in the RGS2 gene, and found significant differences in the distribution of the SNP3 (C+2971G, rs4606) genotypes and alleles of the SNP2 (C-395G, rs2746072) and the SNP3 between completed suicides and the controls. The distribution of the haplotype was also significantly different between the two groups (global p<0.0001). Furthermore, RGS2 immunoreactivity significantly increased in the amygdala and the prefrontal cortex (Brodmann area 9 (BA9)) of the postmortem brain of the suicide subjects. These findings suggest that RGS2 is genetically involved in the biological susceptibility to suicide in the Japanese population.
- Published
- 2008
- Full Text
- View/download PDF
25. Adipocere formation via hydrogenation of linoleic acid in a victim kept under dry concealment.
- Author
-
Nushida H, Adachi J, Takeuchi A, Asano M, and Ueno Y
- Subjects
- Aged, Case-Control Studies, Chromatography, Gas, Fatty Acids, Unsaturated chemistry, Female, Forensic Pathology, Humans, Hydrogenation, Male, Stearic Acids chemistry, Environment, Controlled, Linoleic Acid chemistry, Postmortem Changes
- Abstract
Adipocere formation is well known as a later post-mortem change. We experienced a female victim who had been sealed up in a clothes box for approximately 4 years. We collected several subcutaneous fats as well as visceral fats from the victim to investigate adipocere formation. Fresh subcutaneous fats of one female and five male victims who suddenly died were used as the control. These samples were homogenized and the lipids were extracted with chloroform and methanol followed by injection into gas chromatography-mass spectrometry and gas chromatography. We detected a hydroxy fatty acid in the fat of the case, but not in the controls. Using standard synthetic hydroxy fatty acid, the lipid extract component was identified as 10-hydroxyoctadecanoic acid (10-OH 18:0) and this concentration was quantified. Consequently we confirmed that adipocere was formed much slowly in dry concealment. In addition, the fatty acid composition was compared with the control. Most of the linoleic acid (18:2) disappeared and a peak developed instead. Using standard synthetic fatty acid, this peak was identified as cis-12-octadecenoic acid (cis-12-18:1). This suggests that linoleic acid is hydrogenated to cis-12-octadecenoic acid in the process of adipocere formation.
- Published
- 2008
- Full Text
- View/download PDF
26. Lack of association between endoplasmic reticulum stress response genes and suicidal victims.
- Author
-
Sakurai K, Nishiguchi N, Shirakawa O, Nushida H, Ueno Y, Maeda K, and Hayashi Y
- Subjects
- Adult, Bipolar Disorder genetics, Bipolar Disorder metabolism, DNA-Binding Proteins genetics, DNA-Binding Proteins metabolism, Endoplasmic Reticulum metabolism, Endoplasmic Reticulum Chaperone BiP, Female, Heat-Shock Proteins genetics, Heat-Shock Proteins metabolism, Humans, Male, Middle Aged, Molecular Chaperones genetics, Molecular Chaperones metabolism, Nuclear Proteins genetics, Nuclear Proteins metabolism, Point Mutation, Polymorphism, Single Nucleotide, Regulatory Factor X Transcription Factors, Stress, Psychological metabolism, Transcription Factors, X-Box Binding Protein 1, Endoplasmic Reticulum genetics, Stress, Psychological genetics, Suicide
- Abstract
As lithium has been shown to have a protective effect against suicidal behavior, genes on which mood stabilizers act may be involved in biological susceptibility to suicide. A recent study showed that endoplasmic reticulum (ER) stress response was impaired in the bipolar disorders and the impairment was ameliorated by a mood stabilizer, valproate. We hypothesized that an alteration of ER stress response is involved in the biological susceptibility to suicide through genetic polymorphisms, and examined the association of polymorphisms of X-box binding protein 1 (XBP1) and heat shock 70-kDa protein 5 (HSPA5) genes with suicide. We found no significant difference in the distribution of these polymorphisms between the suicide victims and the controls. These results suggest that the polymorphisms examined in this study are not involved in the susceptibility to suicide of the Japanese.
- Published
- 2007
27. Analysis of phosphatidylcholine oxidation products in human plasma using quadrupole time-of-flight mass spectrometry.
- Author
-
Adachi J, Asano M, Yoshioka N, Nushida H, and Ueno Y
- Subjects
- Adult, Chromatography, High Pressure Liquid, Humans, Male, Middle Aged, Oxidation-Reduction, Spectrometry, Mass, Electrospray Ionization, Blood Chemical Analysis, Phosphatidylcholines blood, Plasma metabolism, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
- Abstract
We report here an application of the previous method for the analysis of phosphatidylcholine (PC) and lysophosphatidylcholine (lysoPC) oxidation products in human plasma using quadrupole time of flight (Q-TOF) mass spectrometry with electrospray ionization. We separated these products using an HPLC C8 column with a gradient of methanol and 10 mM aqueous ammonium acetate. Monohydroperoxides, epoxyhydroxy derivatives, oxo derivatives, and trihydroxides of palmitoyl-linoleoyl (C16:0/C18:2) PC and stearoyl-linoleoyl (C18:0/C18:2) PC were detected mainly as MH+ and [M+Na]+ ions in the plasma of alcoholic patients. Using standard synthetic PC-OH (C16:0/C18:2-OH), the lipid extract component was identified as (C16:0/C18:2-OH) PC based on the product ions of ESI-MS-MS. Using standard synthetic PCOOH (C16:0/C18:2-OOH) as a reference, the PCOOH concentration in plasma was quantified. Two oxidatively modified lysoPCs were also detected. This is the first report showing the presence of epoxyhydroxy derivatives, monohydroperoxides, oxo derivatives, and trihydroxides of (C16:0/C18:2) PC and (C18:0/C18:2) PC, and PC-OH (C16:0/C18:0-OH) in human plasma.
- Published
- 2006
28. No evidence of an association between tyrosine hydroxylase gene polymorphisms and suicide victims.
- Author
-
Hattori H, Shirakawa O, Nishiguchi N, Nushida H, Ueno Y, and Maeda K
- Subjects
- Adult, Aged, Alleles, Female, Humans, Male, Middle Aged, Polymorphism, Genetic, Suicide, Tyrosine 3-Monooxygenase genetics
- Abstract
Functional alternations of noradrenergic and dopaminergic neurotransmission have been implicated in suicidal behavior. A tetranucleotide repeat polymorphism in the first intron of the tyrosine hydroxylase (TH) gene, encoding a rate-limiting enzyme for the synthesis of catecholamines, is reported to have the potential to control expression of the gene and to be associated with suicidal behavior in patients with adjustment disorders. To test the hypothesis that TH gene polymorphisms are involved in suicide through an alteration of TH function, this tetranucleotide repeat polymorphism and the other two SNPs that cause a change in amino acid sequence were examined in suicide victims who completed suicide and control subjects. No significant differences in genotype distribution or allele frequencies were found between the two groups in the three polymorphisms. These findings suggest that these functional polymorphisms are not involved in a biological susceptibility to suicide.
- Published
- 2006
29. Lack of an association between 5-HT receptor gene polymorphisms and suicide victims.
- Author
-
Okamura K, Shirakawa O, Nishiguchi N, Ono H, Nushida H, Ueno Y, and Maeda K
- Subjects
- Alleles, DNA genetics, Female, Gene Frequency, Genotype, Haplotypes, Humans, Japan epidemiology, Male, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction, Polymorphism, Genetic genetics, Receptors, Serotonin genetics, Suicide statistics & numerical data
- Abstract
An association between serotonergic dysfunction in the brain and suicidal behavior has previously been suggested. The high affinity of some antipsychotic and antidepressant drugs to serotonin 6 (5-HT6) receptors, and the predominant localization of 5-HT6 receptors in some limbic regions, suggest that 5-HT6 receptors play a role in the pathogenesis of suicide. The objective of the present study was to examine the association between suicide victims and two polymorphisms of the 5-HT6 receptor gene: a biallelic polymorphism (267C/T) in exon 1 and a trinucleotide repeat polymorphism ([GCC](2/3)) in the 5'-upstream region of the gene. The two polymorphisms were genotyped in 163 suicide victims and 166 controls, and the distribution of genotype and allele frequencies between the two groups were compared. Haplotype frequencies of these two polymorphisms were estimated from genotypic data by the maximum-likelihood method. In both polymorphisms, there were no significant differences in genotype or allele frequencies between the suicide victims and the controls. Moreover, there were no significant differences in the haplotype distributions of these polymorphisms between the two groups. These findings suggest that it is unlikely that the 5-HT6 receptor gene is involved in the susceptibility to suicide.
- Published
- 2005
- Full Text
- View/download PDF
30. Incidence of note-leaving remains constant despite increasing suicide rates.
- Author
-
Shioiri T, Nishimura A, Akazawa K, Abe R, Nushida H, Ueno Y, Kojika-Maruyama M, and Someya T
- Subjects
- Communication, Female, Humans, Japan epidemiology, Male, Suicide statistics & numerical data, Suicide psychology
- Abstract
Suicide notes (SN) are potentially valuable sources of information about the psychological states of the suicidal person. It was hypothesized that there was a significant relation between suicide rate and note-leaving rate and that the incidence of note-leaving was increased during prolonged economic recession. During 21 years (1981-2001) in Kobe, of a total of 18 558 violent deaths, 5161 were due to suicide (27.8%), with 3417 male cases (66.2%) and 1754 female cases (33.8%). For each year the annual suicide rates and note-leaving rates were calculated, and this represents the percentage of committed suicides in which SN were left, among all suicide victims. In spite of the prolonged economic slump, the note-leaving rate remained almost constant (23.4-36.2%). Pearson's correlation coefficient showed no significant correlation between suicide rate and note-leaving rates (r = 0.27, P = 0.23). The finding that the incidence of note-leaving remains constant despite increasing suicide rates may suggest that the reasons for suicide do not affect note-leaving. There are cross-cultural, ethnic, and racial variations in suicidal behaviors. Although this finding may be specific in Japan, further studies of SN are needed to help clarify the suicidal states of mind.
- Published
- 2005
- Full Text
- View/download PDF
31. Association of 14-3-3 epsilon gene haplotype with completed suicide in Japanese.
- Author
-
Yanagi M, Shirakawa O, Kitamura N, Okamura K, Sakurai K, Nishiguchi N, Hashimoto T, Nushida H, Ueno Y, Kanbe D, Kawamura M, Araki K, Nawa H, and Maeda K
- Subjects
- Adult, Aged, Female, Gene Expression Profiling, Genotype, Humans, Japan, Male, Middle Aged, Oligonucleotide Array Sequence Analysis, 14-3-3 Proteins genetics, Genetic Predisposition to Disease, Haplotypes genetics, Polymorphism, Single Nucleotide genetics, Suicide
- Abstract
Genetic factors have been suggested to be involved in suicide. Although some genetic factors, such as serotonergic transduction, have been associated with suicide, the results are inconsistent. There is a possibility that various signaling anomalies are involved in the biological vulnerability to suicide. We carried out a genome-wide gene-expression study in the brains of suicide victims using DNA microarrays;14-3-3 epsilon, which is related to neurogenesis, was one of the genes upregulated in the brains of suicide victims in the microarray analysis. This was confirmed by Western blot analysis. To examine the possibility of the involvement of 14-3-3 epsilon in the pathogenesis of suicide, we investigated the association of the 14-3-3 epsilon gene and completed suicide. We used three high-frequency SNPs (rs1532976, rs3752826, and rs9393) and found a significant association of two alleles (rs1532976 and rs3752826) with completed suicide (p < 0.05). Moreover, the distribution of haplotype revealed a more significant difference between completed suicide and controls (p=0.0005). This finding suggests that 14-3-3 epsilon is a potential suicide susceptibility gene and implies that dysregulation of neurogenesis may be involved in suicide.
- Published
- 2005
- Full Text
- View/download PDF
32. Association between catechol-O-methyltransferase functional polymorphism and male suicide completers.
- Author
-
Ono H, Shirakawa O, Nushida H, Ueno Y, and Maeda K
- Subjects
- Adult, Aged, Chi-Square Distribution, Female, Gene Frequency, Genotype, Humans, Male, Methionine genetics, Middle Aged, Molecular Sequence Data, Valine genetics, Catechol O-Methyltransferase genetics, Polymorphism, Genetic, Sex Characteristics, Suicide
- Abstract
Suicide has been suggested to involve catecholaminergic dysfunction and to be related to genetics. Catechol-O-methyltransferase (COMT) 158Val/Met polymorphism (GenBank Accession No. Z26491) is a polymorphism of the gene encoding COMT, a major enzyme in catecholamine inactivation. The COMT 158Val/Met polymorphism affects COMT activity, that is, the alleles encoding Val and Met are associated with relatively high and relatively low COMT activity, respectively. In this study, we hypothesized that the COMT 158Val/Met polymorphism is associated with suicide. The study population consisted of 163 suicide completers (112 males and 51 females). We found that the genotype distribution of the COMT 158Val/Met polymorphism was significantly different between male suicide completers and male controls (p=0.036), while the frequency of the Val/Val genotype, a high-activity COMT genotype, was significantly less in male suicide completers than in male controls (OR: 0.52; 95% CL: 0.31-0.89; p=0.016). However, this was not the case in females. Our results suggest that the Val/Val genotype is a protective factor against suicide in males., (Copyright 2004 Nature Publishing Group)
- Published
- 2004
- Full Text
- View/download PDF
33. Determination of phosphatidylcholine monohydroperoxides using quadrupole time-of-flight mass spectrometry.
- Author
-
Adachi J, Yoshioka N, Funae R, Nushida H, Asano M, and Ueno Y
- Subjects
- Chromatography, High Pressure Liquid, Hydrogen Peroxide chemistry, Luminescence, Phosphatidylcholines chemistry, Hydrogen Peroxide analysis, Phosphatidylcholines analysis, Spectrometry, Mass, Electrospray Ionization methods
- Abstract
An improved technique for the analysis of phosphatidylcholine (PC) monohydroperoxides was developed using quadrupole time-of-flight (Q-TOF) mass spectrometry with electrospray ionization. Separation was obtained using an HPLC C8 column with a gradient of methanol and 10 mM aqueous ammonium acetate. Monohydroperoxides of palmitoyl-linoleoyl (C16:0/C18:2) PC, stearoyl-linoleoyl (C18:0/C18:2) PC, and oleoyl-linoleoyl (C18:1/C18:2) PC were detected mainly as MH(+) and [M+Na](+) ions in the heart of the intact rat. Using standard synthetic PCOOH (C16:0/C18:2-OOH), the lipid extract component was identified as (C16:0/C18:2-OOH) PC based on the product ions of ESI-MS-MS and, the PCOOH concentration was quantitated using HPLC with chemiluminescence detection. Two epoxyhydroxy derivatives of the three PCs mentioned above were also detected. This is the first report to show the presence of monohydroperoxides and epoxyhydroxy-derivatives of (C16:0/C18:2)PC, (C18:0/C18:2)PC, and (C18:1/C18:2) PC in the rat heart.
- Published
- 2004
- Full Text
- View/download PDF
34. Economic slump and suicide method: preliminary study in Kobe.
- Author
-
Abe R, Shioiri T, Nishimura A, Nushida H, Ueno Y, Kojima M, Kitamura H, Akazawa K, and Someya T
- Subjects
- Adolescent, Adult, Aged, Cross-Sectional Studies, Female, Humans, Japan epidemiology, Male, Middle Aged, Statistics as Topic, Suicide psychology, Unemployment psychology, Unemployment statistics & numerical data, Suicide Prevention, Cause of Death, Economics statistics & numerical data, Suicide statistics & numerical data
- Abstract
During the recent half decade, Japan's suicide rate at approximately 25 deaths per 100 000 people has been one of the highest rates in the world. From the perspective of suicide prevention by restricting access to suicidal means, the aim of the present study was to examine what kind of suicidal method increased during prolonged economic slump. During 21 years (1981-2001), for all suicide victims (5161 cases) the gender, age, and suicide methods were investigated. The yearly full unemployment rate was also used as a representative socioeconomic factor during the same periods in Japan using government statistics, and the relationship between methods of suicide and full unemployment rate was investigated. Pearson's correlation suggested that there was a significant correlation only for hanging rate (r = 0.736, P < 0.001), but not for the percentages of other methods of suicide. This finding that unemployed persons may have a susceptibility towards certain suicide methods could help in the prevention of suicides. Mental health in Japan should be given more attention, especially for the working population, and social programs offering help should be considered widely.
- Published
- 2004
- Full Text
- View/download PDF
35. Sexual asphyxia by hanging--a case report and a review of the literature.
- Author
-
Ueno Y, Asano M, Nushida H, Nakagawa K, Adachi J, and Nagasaki Y
- Subjects
- Adult, Autopsy, Fatal Outcome, Humans, Male, Paraphilic Disorders psychology, Accidents, Asphyxia etiology, Paraphilic Disorders complications
- Abstract
A case of sexual asphyxial death by hanging is presented. A 35-year-old male, found dead lying on his face in a bed of a truck cab, had hanged himself from a window frame using a leather belt. He was completely naked. There were pornographic and sadomasochistic magazines beneath his face, opened to pages depicted nude photographs of a woman. Autopsy findings revealed a ligature mark on the neck and petechial hemorrhages in the conjunctivae, but there were no hemorrhages in the neck muscles or fractures of the hyoid bone or the thyroid cartilage. The alcohol levels in the blood and urine were 0.78 and 0.45 mg/ml, respectively. The circumstances suggested that his death was accidental, and due to asphyxia by hanging performed to enhance sexual gratification during masturbation. Sexual asphyxia is reviewed and discussed.
- Published
- 2003
- Full Text
- View/download PDF
36. Fatty acid profile in skeletal muscle of the rat in response to acute (2.5 hours) and prolonged (6 weeks) ethanol-dosage.
- Author
-
Adachi J, Kudo R, Nushida H, Ueno Y, Koll M, and Preedy VR
- Subjects
- Aldehyde Dehydrogenase antagonists & inhibitors, Animals, Cyanamide administration & dosage, Cyanamide pharmacology, Dose-Response Relationship, Drug, Drug Administration Schedule, Ethanol administration & dosage, Male, Muscle Fibers, Skeletal drug effects, Muscle Fibers, Skeletal metabolism, Rats, Rats, Wistar, Sodium Chloride administration & dosage, Time Factors, Ethanol pharmacology, Fatty Acids metabolism, Muscle, Skeletal drug effects, Muscle, Skeletal metabolism
- Abstract
We tested the hypothesis that phospholipids are altered in skeletal muscles of rats exposed to ethanol for either acute (2.5 hours) or prolonged (6 weeks) periods. In acute studies, rats were dosed with saline (0.15 mmol/l; controls) or ethanol (75 mmol/kg body weight; treated). There were four groups: (A) saline (control); (B) cyanamide (an aldehyde dehydrogenase inhibitor); (C) ethanol; and (D) cyanamide + ethanol. In prolonged studies, two groups of rats were fed liquid diets containing 35% of total dietary energy as either glucose [group (E)] or ethanol [group (F)]. At the end of the treatments, membrane phospholipids were measured in soleus (Type I fibre-predominant) and plantaris (Type II fibre-predominant) muscle. In acute studies, ethanol alone [(A) vs. (C)] and cyanamide + ethanol [(A) vs. (D)] significantly increased 18 : 2 in plantaris (p < 0.05), whereas in soleus none of the treatments had any effect on the phospholipids. In prolonged studies [(E) vs. (F)], there were decreases in 16 : 0 (p < 0.05) and 18 : 1 (p < 0.01) and increases in 18 : 2 (p < 0.001) in plantaris. In soleus, decreases in 18 : 1 (p < 0.05) and increases in 18 : 2 (p < 0.01) occurred. In conclusion, alterations in the proportions of 16 : 0, 18 : 1 and 18 : 2 provide evidence of an altered membrane domain which may contribute to the pathogenesis of alcohol-induced muscle disease. Changes due to prolonged exposure are more profound than those in acute exposure and the preferential effects in Type II plantaris may reflect the greater susceptibility of this muscle to alcohol.
- Published
- 2003
- Full Text
- View/download PDF
37. Accidental hanging by a sweater: an unusual case.
- Author
-
Nurhantari Y, Asano M, Nushida H, Nagasaki Y, Kudo R, Nakagawa K, Adachi J, and Ueno Y
- Subjects
- Aged, Alcoholic Intoxication complications, Asphyxia complications, Autopsy, Clothing, Humans, Male, Motorcycles, Neck pathology, Accidents, Alcoholic Intoxication pathology, Asphyxia pathology
- Abstract
An accidental atypical hanging with the collar of a sweater is reported. A 67-year-old man was found dead in the sitting position with the collar of his sweater hanging off the brake handle of a motorcycle. Autopsy findings revealed a ligature mark on the surface of the neck; hemorrhages in the sternohyoid muscles; submucosal hemorrhages in the left greater horn of the hyoid bone; a large degree of submucosal petechial hemorrhages in the larynx, oral mucosa, and palpebral conjunctivae; and dark-red liquid blood with little clotting in the heart cavities. The alcohol levels in the blood and urine were 2.84 mg/ml and 3.52 mg/ml, respectively. It was concluded that the man had died from hanging by the sweater, and it was speculated that when he became inebriated, he might have lost consciousness and then fell with the collar of his sweater hanging from the brake handle of the motorcycle.
- Published
- 2002
- Full Text
- View/download PDF
38. Lack of an association between 5-HT1A receptor gene structural polymorphisms and suicide victims.
- Author
-
Nishiguchi N, Shirakawa O, Ono H, Nishimura A, Nushida H, Ueno Y, and Maeda K
- Subjects
- Female, Genotype, Humans, Male, Middle Aged, Receptors, Serotonin, 5-HT1, Risk Factors, Polymorphism, Genetic, Receptors, Serotonin genetics, Suicide
- Abstract
A serotonergic dysfunction in the brain has been reported to be involved in suicidal behavior independently of the presence of a specific psychiatric disorder. Serotonin 1A (5-HT1A) receptors are known to be located on serotonergic nerve terminals and to be involved in the presynaptic regulation of serotonin release. Genetic factors partly explain the risks for suicide, and a suicide completion group is thought to be more uniform than a suicide attempt group. To explore the hypothesis that the 5-HT1A receptor-induced serotonergic dysfunction is implicated genetically in suicide, we focused on the structural polymorphisms, Pro16Leu and Gly272Asp, of the 5-HT1A receptor gene, and examined the association between suicide victims who completed suicide and these two polymorphisms. In both polymorphisms, we found no significant difference in genotype distribution or allele frequencies between suicide victims and controls. These findings suggest that neither of these two polymorphisms is associated with suicide victims and it is unlikely that the 5-HT1A receptor gene is implicated in the susceptibility to suicide., (Copyright 2002 Wiley-Liss, Inc.)
- Published
- 2002
- Full Text
- View/download PDF
39. No evidence of an association between a functional monoamine oxidase a gene polymorphism and completed suicides.
- Author
-
Ono H, Shirakawa O, Nishiguchi N, Nishimura A, Nushida H, Ueno Y, and Maeda K
- Subjects
- Adult, Aged, Alleles, DNA genetics, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Minisatellite Repeats genetics, Polymorphism, Genetic, Monoamine Oxidase genetics, Suicide
- Abstract
Monoamine oxidase A (MAOA) has been implicated in the control of aggression and/or impulsivity in humans and been involved in suicide. This gene has a functional polymorphism in which there is a variable number tandem repeat (VNTR) in the upstream region (MAOA-uVNTR). We hypothesized that MAOA dysfunction due to this polymorphism was associated with suicide genetically through the disinhibition of aggression and/or impulsivity. We performed an association study between completed suicides and the MAOA-uVNTR polymorphism. No significant difference in genotype distribution or allele frequencies was found between completed suicides and comparison groups either in males or females. These results show no evidence of an association between the MAOA-uVNTR polymorphism and completed suicides and suggest that MAOA is not involved in the susceptibility to suicide., (Copyright 2002 Wiley-Liss, Inc.)
- Published
- 2002
- Full Text
- View/download PDF
40. No evidence of an association between 5HT1B receptor gene polymorphism and suicide victims in a Japanese population.
- Author
-
Nishiguchi N, Shirakawa O, Ono H, Nishimura A, Nushida H, Ueno Y, and Maeda K
- Subjects
- Adult, Aged, Alleles, DNA genetics, Female, Gene Frequency, Genotype, Humans, Japan, Male, Middle Aged, Polymorphism, Genetic, Receptor, Serotonin, 5-HT1B, Receptors, Serotonin genetics, Suicide
- Abstract
Serotonergic systems have been reported to mediate the control of aggression and/or impulsivity in humans and to be involved in suicidal behavior. Neurochemical studies showing serotonergic dysfunction in suicide appear to support the functional alteration of serotonergic systems due to gene polymorphisms. Knock-out mice of the 5HT1B receptor gene have been reported to result in increased aggression. We hypothesized that the 5HT1B receptor-mediated serotonergic dysfunction was implicated in suicide through disinhibition of aggression and/or impulsivity. To explore this hypothesis, we examined the association between suicide victims who completed suicide and the 5HT1B receptor gene G861C polymorphism. No significant differences in genotype distribution and allele frequencies were found between suicide victims and controls. Though there is the possibility of failing to detect small effects, these results show no evidence of an association between the 5HT1B receptor gene G861C polymorphism and suicide victims in a Japanese population and indicate that it is unlikely that the 5HT1B receptor is implicated in the susceptibility to suicide., (Copyright 2001 Wiley-Liss, Inc.)
- Published
- 2001
- Full Text
- View/download PDF
41. Tryptophan hydroxylase gene polymorphisms are not associated with suicide.
- Author
-
Ono H, Shirakawa O, Nishiguchi N, Nishimura A, Nushida H, Ueno Y, and Maeda K
- Subjects
- Adult, Alleles, DNA genetics, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Suicide psychology, Tryptophan Hydroxylase genetics
- Abstract
Several lines of evidence suggest a serotonergic dysfunction involved in the biological susceptibility of suicide. Abnormalities of serotonergic markers such as 5-hydroxyindoleacetic acid and prolactin response to fenfluramine have been demonstrated in suicide subjects. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin biosynthesis, is one of the most important regulating factors in the serotonergic system. Recently, polymorphisms of the TPH gene have been identified and some of these polymorphisms have been suggested to be associated with suicide, but the results are still inconsistent. We examined whether the -6526A/G polymorphism in the promoter region and the 218A/C polymorphism in intron 7 of the TPH gene were associated with suicide using 132 Japanese suicide victims. No significant difference in genotype distribution and allele frequencies of these polymorphisms was found between the suicide victims and the controls. We concluded neither the -6526A/G polymorphism nor the 218A/C polymorphism of the TPH gene is likely to have a major effect on the susceptibility of suicide. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:861-863, 2000., (Copyright 2000 Wiley-Liss, Inc.)
- Published
- 2000
- Full Text
- View/download PDF
42. [An autopsy case of pulmonary thromboembolism associated with chlorine gas poisoning].
- Author
-
Asano M, Nushida H, Ueno Y, Yata K, Adachi J, and Tatsuno Y
- Subjects
- Accidents, Occupational, Acute Disease, Adult, Autopsy, Death, Sudden pathology, Gases, Humans, Inhalation Exposure, Male, Pulmonary Embolism pathology, Chlorine poisoning, Death, Sudden etiology, Pulmonary Embolism etiology
- Abstract
We report a rare case of sudden death of a patient with acute pulmonary thromboembolism associated with chlorine gas poisoning. A 21-year-old man in a water-filtration plant accidentally inhaled highly concentrated chlorine gas. He was immediately brought to a hospital after exposure. On admission, the patient had clouding of consciousness, dyspnea, and deep cyanosis. Arterial blood gas values indicated severe hypoxemia; PaO2 was 35.9 mmHg and PaCO2 was 42.4 mmHg. The clinical course was uneventful and he was satisfactorily recovering. However, ten days after admission he became sick and markedly cyanotic. He lost consciousness and then he went into cardiopulmonary arrest. Despite efforts at resuscitation, he died. An autopsy revealed bilateral pulmonary thromboembolism, although he apparently did not have any risk factor for embolism. The toxicity of chlorine gas may be related to the pulmonary thromboembolism, but the mechanisms leading to his death are unclear.
- Published
- 1999
43. The Kobe earthquake and reduced suicide rate in Japanese males.
- Author
-
Shioiri T, Nishimura A, Nushida H, Tatsuno Y, and Tang SW
- Subjects
- Adolescent, Adult, Cause of Death, Coroners and Medical Examiners statistics & numerical data, Female, Humans, Japan epidemiology, Life Change Events, Male, Mortality, Sex Factors, Suicide trends, Disasters, Suicide statistics & numerical data
- Published
- 1999
- Full Text
- View/download PDF
44. [An autopsy case of sudden death due to Chagas' disease].
- Author
-
Nishimura A, Ueno Y, Fujiwara S, Nushida H, and Tatsuno Y
- Subjects
- Adult, Animals, Chagas Cardiomyopathy parasitology, Chagas Cardiomyopathy pathology, Death, Sudden, Cardiac pathology, Humans, Male, Myocarditis pathology, Trypanosoma cruzi isolation & purification, Chagas Cardiomyopathy complications, Death, Sudden, Cardiac etiology
- Abstract
An autopsy case of sudden death of a 41-year-old male Brazilian with Chagas' disease in reported. In his life time, right handle branch block and ventricular premature contractions were marked in electrocardiogram. Autopsy revealed striking dilatation of both cardiac ventricles. Histopathologically, extensive myocardial fibrosis due to chronic interstitial myocarditis was observed. On myocardial tissue preparation performed Giemsa's stain, leishmania foci of Trypanosoma crusi were detected around the myocardial fibrosis.
- Published
- 1997
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.