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Amaç: Tromboelastogram parametrelerindeki değişiklerin standart olarak önerilen AntiFXa aktivitesi ile karşılaştırılarak bu testin enoksaparin tedavisinin monitörizasyonundaki rolünün incelenmesidir. Gereç ve Yöntem: ST segment yükselmesi olmayan miyokard infarktüsü tanısıyla koroner yoğun bakım ünitesine yatırılan 25 hasta çalışmaya alınmıştır. Hastalara yatış anında iki tüp kan alınmış ve 1mg/kg enoksapirinin üçüncü dozu yapıldıktan 4 saat sonra iki tüp kan daha alınmıştır. Hastalara AntiFXa, tromboelastogram, aktive koagülasyon zamanı bakılmıştır. Bulgular: Enoksoparin uygulaması sonrası aktive koagülasyon zamanı değerinde bir miktar artış izlenmekle birlikte bunun anlamlı olmadığı görüldü (p₌0.094). Enoksoparin sonrası tromboelastogram parametrelerinden maksimum amplitüde(MA) azalmış (MA bazal 65.4±11.9 sonra 63.4±7.8), R zamanı artmış (5±1.7 den 8.4±4.6,), K zamanı artmış (1.89±1.06 dan 2.56±1.4), açı azalmıştır. (66.34±5.6 dan 57.9±11.4). AntiFXa artmıştır (0.122±0.06 dan 0.501±0.359). Sonuç: Tromboelastogram parametreleri değerlendirildiğinde tipik artmış bir prokoagülan aktivite olmamakla birlikte kısmen artmış bir fibrinolitik aktivite saptanmıştır.

Bazı yerli ve yabancı Yunus Emre incelemecileri ve yorumcuları onun panteist olduğunu iddia etmişlerdir. Bu görüşte olanlar, Yunus Emre'yi batılı oryantalist bakış açısıyla değerlendirmişlerdir. Ancak Yunus Emre, panteist değildir. O, saf bir İslam imanına sahip olan bir Türk şairidir. Şiirlerinde İslam tasavvufunun vahdet-i vücut felsefesini işlemiştir. İslam dışı bir inanç sistemi olan panteizm ile İslam tasavvufu arasında bazı benzerlikler var gibi görünse de aslında bu iki inanış sistemi tamamen birbirine zıttır. Panteizm, yaratıcı ile yaratılanı birleştirir. Buradan hareketle yaratılanları da tanrılaştırmış olur. Buradan da naturalizme ve materyalizme gidilir. İslam ise Yaratıcı ile yaratılanı ayırır ve yaratılanı tamamen yaratana bağlar, yaratılanı tanrılaştırmaz. Dolayısıyla Yunus Emre'ye panteist demek büyük bir yanılgıdır.

Giriş ve Amaç: Yüksek Lipoprotien (a) [Lp (a)] düzeylerinin artmış koroner arter hastalığı riski ile ilişkili olduğu bilinmektedir. Çalışmamızda ilk kez akut koroner sendrom tanısı ile başvuran hastalarda, serum Lp (a) seviyesi ile klinik prezentasyon arasındaki ilişkiyi araştırmayı planladık. Gereç ve Yöntem: İlk kez akut koroner sendrom tablosu ile başvuran hastalar prospektif olarak çalışmamaıza dahil edildi. Hastalara ait demografik veriler dosya kayıtlarından toplandı. Lp (a) ve diğer lipid parametrelerinin ölçümü başvuru sonrası en az sekiz saatlik açlığı takiben alınan venöz kandan yapıldı. Bulgular: 105 ST segment elevasyonlu miyokard infarktüsü (STEMI), 132 ST segment elevasyonu olmayan miyokard infarktüsü (NSTEMI) hastası olmak üzere toplam 237 hasta çalışmaya dahil edildi. Yaş ve cinsiyet açısından gruplar arasında anlamlı bir fark yoktu. Serum Lp (a) seviyeleri STEMI hastalarında daha yüksek saptansa da iki grup arasında anlamlı bir fark yoktu [10.2 (19.7) mg/dl vs. 8.5 (12.7) mg/dl, p: 0.393]. Lp (a) ≥ 30 mg/dl olup, LDL ≥ 100 mg/dl olanlar, LDL < 100 mg/dl olanlara göre 4.95 kat daha fazla STEMI kliniği ile prezente olmakta idiler (odds oranı:4.95, % 95 güven aralığı:1.31-16.5, p:0.027). Diğer taraftan LDL ≥ 100 mg/dl olup, Lp (a) ≥ 30 mg/dl olanların, Lp (a) < 30 mg/dl olanlara göre 2.45 kat daha fazla STEMI kliniği ile prezente olduklarını saptadık (odds oranı:2.45, % 95 güven aralığı:1.04-5.6, p:0.039). Sonuç: Lp (a) ≥ 30 mg/dl ve LDL ≥ 100 mg/dl olan hastaların akut koroner sendrom klinik prezentasyonlarının STEMI lehine olduğunu saptadık. Bu hasta grubunda daha erken ve etkin yaşam tarzı değişikliklerine ihtiyaç gözükmektedir.

BACKGROUND Myocardial bridge (MB) is generally considered as a benign condition, but it may trigger atherosclerosis, especially in the adjacent proximal coronary artery segment. In this study, we aimed to investigate whether the Framingham risk score (FRS) or atherogenic indices are risk factors for coronary atherosclerosis in patients with MB in the left anterior descending coronary artery (LAD). METHODS We performed a retrospective study evaluating 155 patients who have MB in LAD. The patients were evaluated in two groups according to the presence of atherosclerosis (74 patients in atherosclerotic group vs. 81 patients in non-atherosclerotic group). Baseline characteristics, FRS and atherogenic indices were reviewed between groups. Significant independent risk factors for coronary atherosclerosis were investigated by logistic regression analysis. RESULTS Patients in atherosclerotic group were significantly older (58.15 ± 10.04 vs. 50.22 ± 9.27 years, p

In this study, we investigated whether the CHA2DS2-VASc score could be used to estimate the need for hospitalization in the intensive care unit (ICU), the length of stay in the ICU, and mortality in patients with COVID-19. Patients admitted to Merkezefendi State Hospital because of COVID-19 diagnosis confirmed by RNA detection of virus by using polymerase chain reaction between March 24, 2020 and July 6, 2020, were screened retrospectively. The CHA2DS2-VASc and modified CHA2DS2-VASc score of all patients was calculated. Also, we received all patients' complete biochemical markers including D-dimer, Troponin I, and c-reactive protein on admission. We enrolled 1000 patients; 791 were admitted to the general medical service and 209 to the ICU; 82 of these 209 patients died. The ROC curves of the CHA2DS2-VASc and M-CHA2DS2-VASc scores were analyzed. The cut-off values of these scores for predicting mortality were >= 3 (2 or under and 3). The CHA2DS2-VASc and M-CHA2DS2-VASc scores had an area under the curve value of 0.89 on the ROC. The sensitivity and specificity of the CHA2DS2-VASc scores were 81.7% and 83.8%, respectively; the sensitivity and specificity of the M-CHA2DS2-VASc scores were 85.3% and 84.1%, respectively. Multivariate logistic regression analysis showed that CHA2DS2-VASc, Troponin I, D-Dimer, and CRP were independent predictors of mortality in COVID-19 patients. Using a simple and easily available scoring system, CHA2DS2-VASc and M-CHA2DS2-VASc scores can be assessed in patients diagnosed with COVID-19. These scores can predict mortality and the need for ICU hospitalization in these patients.

Despite the lack of supporting data, many clinics perform sheath removal 4-6 hours after femoral percutaneous coronary intervention to reduce the risk of possible access site complications. This study aims to examine the effects of sheath removal immediately after the procedure on access site complications and patient comfort.This prospective study included 349 patients who underwent percutaneous coronary intervention via the femoral site and 6 French guiding catheters. The sheath in the early group was removed immediately after the procedure without checking the activated clotting time levels but after 4 hours in the late group. Access site complications were recorded and patient comfort was evaluated using the Visual Analog Scale.Patients were divided into 2 groups: patients in the early removal group (n=171) and in the late removal group (n= 178). There was no statistically significant difference between the 2 groups in terms of access site complications. Three patients in the early removal group and 4 patients in the late removal group developed a hematoma. Six patients in the early removal group and 10 patients in the late removal group showed ecchymosis.TheVisualAnalogScalescorewas statistically significantly lower intheearly removal group compared with that in the late removal group [2 (1-3) vs. 3 (2-4), P.001].This study shows that immediate sheath removal is safe and more comfortable for patients with percutaneous coronary intervention who received weightadjusted dose of heparin, regardless of the percutaneous coronary intervention levels after the procedure.

Coronary artery perforations are one of the most feared, rare, and catastrophic complication of percutaneous coronary intervention. Despite the remarkable increase in coronary angiography and percutaneous coronary intervention, there is no large database that collects coronary artery perforation for the Turkish population. Our study aimed to report our experience over a 10-year period for clinical and angiographic characteristics, management strategies, and outcomes of coronary artery perforation during the percutaneous coronary intervention at different cardiology departments in Turkey.The study data came from a retrospective analysis of 48 360 percutaneous coronary intervention procedures between January 2010 and June 2020. A total of 110 cases who had coronary artery perforation during the percutaneous coronary intervention were found by angiographic review. Analysis has been performed for the basic clinical, angiographic, procedural characteristics, the management of coronary artery perforation, and outcome of all patients.The coronary artery perforation rate was 0.22%. Out of 110 patients with coronary artery perforation, 66 patients showed indications for percutaneous coronary intervention with acute coronary syndrome and 44 patients with stable angina pectoris. The most common lesion type and perforated artery were type C (34.5%) and left anterior descending (41.8%), respectively. The most observed coronary artery perforation according to Ellis classification was type III (37.2%). Almost 52.7% of patients have a covered stent implanted in the perforated artery. The all-cause mortality rate of coronary artery perforation patients in the hospital was 18.1%.The observed rate of coronary artery perforation in our study is consistent with the studies in this literature. However, the mortality rates related to coronary artery perforation are higher than in other studies in this literature. Especially, the in-hospital mortality rate was higher in type II and type III groups due to perforation and its complications. Nevertheless, percutaneous coronary intervention should be done in selected patients despite catastrophic complications.

Objectives: SMYRNA-HF study is a prospective multicenter registry study to determine the profiles of patients with heart failure (HF) in Turkey. This study aimed to present the baseline characteristics of preliminary cohort by comparing them according to different HF phenotypes. Methods: The first SMYRNA-HF cohort included outpatients with HF from 9 centers. Patients were classified into three HF phenotypes as HF with reduced ejection fraction (HFrEF), mildly reduced EF (HFmrEF), and preserved EF (HFpEF) as recommended by guidelines. Results: Overall, 298 patients were included in this preliminary analysis that 57% of the patients were classified as having HFrEF, 33.3% as having HFpEF, and 9.7% as having HFmrEF. Female gender was more common in HFpEF (p = 0.003). Age, frequency of diabetes mellitus, use of angiotensin-converting enzyme inhibitors/angiotensin receptor blocker, use of beta-blocker, use of daily loop diuretic, heart rate, blood urea nitrogen levels, lipid profiles, hemoglobin, white blood cell, platelet levels were similar among three HF phenotypes. Body mass index (BMI) (p < 0.001), frequency of hypertension (HT) (p < 0.001), and atrial fibrillation (AF) (p = 0.015) were higher in HFpEF. Ischemic etiology (p < 0.001) was less frequent in HFpEF. Use of mineralocorticoid receptor antagonist was higher in HFrEF (p < 0.001). Conclusions: Our study presented the baseline characteristics of outpatients with HF in Turkey. There were significant differences among HF phenotypes in terms of gender, BMI, frequency of HT, AF, and ischemic etiology. Treatment implementations seem to follow the guidelines. Although the rates are low, new treatment approaches recommended in the most recent guidelines seem to enter clinical practice.

Background Some of the drugs used for the treatment of coronavirus disease (COVID‐19) can increase the risk of corrected QT (QTc) interval prolongation, which may trigger arrhythmia or even death. Due to the low sensitivity of the reverse transcriptase‐polymerase chain reaction (RT‐PCR) test, chest computed tomography (CT) imaging is being used for COVID‐19 diagnostic correlation and to evaluate whether there is pneumonic involvement in the lung. Objective In this study, we aimed to investigate the correlation between lung changes on CT and QTc interval changes on ECG in non‐ICU patients with COVID‐19 who have a positive PCR test when using drugs that can prolong the QTc interval. Methods This was a single‐centre retrospective cohort study of hospitalized non‐ICU patients. The study included 344 patients (56.1% men) with a mean age of 46.34 ± 17.68 years. The patients were divided into four groups according to their chest CT results: those having typical, atypical, indeterminate, or no pneumonic involvement. The mean QTc intervals and heart rates calculated from electrocardiograms (ECG) during admission to the hospital and after the treatment were compared. Results No significant differences were found between the groups’ age, gender, and body mass index (BMI). In addition, no significant differences were found between the groups’ mean QTc interval values at admission (P:.127) or after the treatment (P:.205). The groups’ heart rate values were also similar, with no significant differences in the mean heart rate on admission (P:.648) and post‐treatment (P:.229) ECGs. Conclusion This study has demonstrated findings of COVID‐19 infection based on chest CT does not correlate with QT interval prolongation in non‐ICU COVID‐19 patients. There is a need for additional larger studies investigating the effect of chest CT findings on QT interval prolongation and bradycardia in COVID‐19 patients.

Objective: In this study, we aimed to investigate the effect of hypertension (HT) and antihypertensive treatment on prognosis, which is one of the cardiovascular risk factors affecting the prognosis of COVID-19. Methods: We included 117 patients diagnosed with COVID-19 by nasopharyngeal polymerase chain reaction (PCR). The patients were divided into a hypertensive group and a control group. Biochemical, complete blood count and imaging data of the patients were recorded. Mortality of patients with and without HT was evaluated. The effect of antihypertensive therapy on mortality was evaluated. Results: In thorax CT, ground glass opacity and pneumonic consolidation were found statistically significantly higher in the hypertensive group (p

Objective: The D-SPIRIT registry is designed to investigate the safety and effectiveness of dabigatran etexilate in patients with atrial fibrillation in routine clinical practice. Methods: D-SPIRIT is the first national, multicenter, prospective, observational, postmarketing registry that investigates the usage of dabigatran in real life. A total of 326 noveloral anticoagulant-eligible patients with atrial fibrillation who have been taking dabigatran etexilate therapy for stroke prevention at least 6 months from 9 different centers were enrolled into the registry. Patients were followed up for 2 years to evaluate the effectiveness and safety of the treatment. All adverse clinical events including bleeding, thromboembolic events, stroke, systemic embolism, transient ischemic attack, myocardial infarction, and all-cause death were recorded. Results: The mean age was 71.1 +/- 9.6 years, and 57.4% of the study participants were female. The mean CHA(2)DS(2)-VASc (congestive heart failure, hypertension, age >= 75 years, diabetes mellitus, stroke or transient ischemic attack [TIA], vascular disease, age 65-74 years, sex category) score was 3.4 +/- 1.6. The cumulative adverse clinical events rate was 6.30% per year. The rate for embolic events including TIA, ischemic stroke, and peripheral embolism was 1.26% per year. The rate for major bleeding was 2.20% per year, and the mortality rate was 0.94% per year. Conclusion: This registry obtained an important overview of the current safety and effectiveness of the dabigatran etexilate in Turkey. Our results indicate similar rates of thromboembolic and bleeding events with pivotal phase 3 trial and other real-life registries. However, rate of undertreatment usage of dabigatran etexilate in real life was found to be considerable., Ege University, Research and Application Center of Drug Development and Pharmacokinetics, The study was sponsored by Ege University, Research and Application Center of Drug Development and Pharmacokinetics

Background Hydroxychloroquine (HCQ) and azithromycin (AZM) are widely used in off‐label treatment of novel coronavirus disease (COVID‐19). However, cardiac safety of these drugs is still controversial in COVID‐19. Therefore, we aimed to evaluate association of HCQ or HCQ + AZM treatment regimens, corrected QT (QTc) interval and malignant ventricular arrhythmias in hospitalized patients. Methods This is a single‐center, retrospective and observational study. All data were extracted from the electronic medical records. The initial and post‐treatment mean QTc intervals were calculated and compared in patients with HCQ alone or HCQ + AZM therapy. Associated factors with QTc prolongation, the incidence of ventricular arrhythmia during treatment and in‐hospital mortality because of ventricular arrhythmias were evaluated. Results Our cohort comprised 101 hospitalized COVID‐19 patients (mean age of 49.60 ± 18 years, 54.4% men). HCQ + AZM combination therapy group (n = 56) was more likely to have comorbidities. After 5‐days treatment, 19 (18.8%) patients had QTc prolongation, and significant increase in the QTc interval was observed in both two groups (P

Aim: The prevalence of atrial fibrillation (AF) in patients with myocardial infarction (MI) ranges widely and has been reported to be as high as 21%. However, the demographic, clinical, and angiographic characteristics of AF patients with de novo MI is unclear. The aim of this study was to investigate the prevalence of patients presenting with de novo MI with AF. Methods: The study was performed as a sub-study of the MINOCA-TR (Myocardial Infarction with Non-obstructive Coronary Arteries in Turkish Population) Registry, a multicenter, cross-sectional, observational, all-comer registry. MI patients without a known history of stable coronary artery disease and/or prior coronary revascularization were enrolled in the study. Patients were divided into AF and Non-AF groups according to their presenting cardiac rhythm. Results: A total of 1793 patients were screened and 1626 were included in the study. Mean age was 61.5 (12.5) years. 70.7% of patients were men. Prevalence of AF was 3.1% (51 patients). AF patients were older [73.4 (9.4) vs. 61.0 (12.4) years, p

Amaç: Çalışmamızda, nonvalvüler atriyal fibrilasyon tedavisinde kullanılan Dabigatranın trombosit indeksleri üzerindeki etkisini araştırmayı amaçladık. Materyal ve Metod: Çalışmamıza ocak 2018 ve aralık 2019 tarihleri arasında kardiyoloji polikliniğine başvurup, non valvüler atriyal fibrilasyon tanısı ile endikasyon dahilinde dabigatran tedavisi başlanmış 69 hasta dahil edilmiştir. Hastaların dosyaları taranarak dabigatran başlanmadan önceki ve tedavi altında 6 ay sonraki laboratuar parametreleri değerlendirmeye alındı. Bulgular: Çalışmaya 69 hasta dahil edilidi. Yaş ortalaması 69 ± 9 olup, hastaların %62.3’si kadın, %37.7’si erkek idi. Hastaların %87’sinde hipertansiyon, %26.1’inde diabetes mellitus, %17.4’ünde dislipidemi mevcuttu. 6 aylık dabigatran kullanımı sonrasında, başta MPV olmak üzere, platalet sayısı ve diğer trombosit indekslerinde anlamlı bir değişiklik saptanmadı. Sonuç: 6 aylık bir tedavi periyodunda dabigatranın MPV başta olmak üzere, trombosit sayısı ve diğer platelet indeksleri üzerinde anlamlı bir değişikliğe yol açmadığını gözlemledik. Çalışma verilerimiz ışığında Dabigatran’ın AF’de inme ve tromboembolinin önlenmesinde, platelet indeksleri üzerine olan etkisinin bir anlam ifade etmediği görülmektedir.

Osmanlı Devleti’nin son yıllarında ve Türkiye Cumhuriyeti Devleti’nin ilk dönemlerinde Türk aile ve eğitim kurumlarında önemli sorunlar vardır. Türk aile ve eğitim kurumları bozulmaya başlamış, kendisini yenileyememiştir. Yabancı eğitim kurumlarına eğilim artmıştır. Bu yüzden Türk çocukları yabancı eğitim kurumlarında kendi kültürlerinden ve millî kimliklerinden uzaklaşmaya başlamıştır. Amerika’nın Türkiye üzerinde bazı emperyalist emelleri vardır. Bu emellerine ulaşabilmek için eğitim kurumunu alet olarak kullanmıştır. Bu bağlamda ülkemizde açtığı Müslümanlıklarından uzaklaştırmaya çalışmıştır. Müfide Ferit Tek, “Pervaneler” adlı romanında Batılı misyoner okullarının Türk çocuklarını kendi kimliklerinden uzaklaştırması üzerinde durmuştur, In the last years of the Ottoman Empireand in the first periods of the Republic of Turkey, there are important problems in the Turkish family and educational institutions. Turkish family and educational institutions have started to deteriorate and have not renewed itself. Thetrend towards foreign education institutions has increased. Therefore, Turkish children have begun to move away from their own culture and national identity in foreign education institutions. America has some imperialist ambitions over Turkey. America used the education institution as a tool to achieve these goals. In this context, America tried to remove Turkish children from Turkishness and Islamism with missionary schools he opened in our country. Müfide Ferit Tek, in her novel “Pervaneler”, focused on there moval of Turkish children from their identity by Western missionary schools

Objective: In this study, we aimed to investigate the association of fragmented QRS (f-QRS) with in-hospital death in patients with severe novel coronavirus disease 2019 (COVID-19). Methods: This was a retrospective and observational study. A total of 201 consecutive patients with severe COVID-19 were enrolled. Demographic data, laboratory parameters, medications, electrocardiographic (ECG) findings, and clinical outcomes were recorded. Patients with and without f-QRS were compared, and predictors of all-cause in-hospital mortality were analyzed. Results: A total of 135 patients without f-QRS (mean age of 64 years, 43% women) and 66 patients with f-QRS (mean age of 66 years, 39% women) were included. C-reactive protein (CRP), D-dimer, troponin I, ferritin levels, and CRP to albumin ratio were significantly higher in patients with f-QRS. The need for invasive mechanical ventilation (63.6% vs. 41.5%, p=0.003) and all-cause in-hospital mortality [54.5% vs. 28.9%, log rank p=0.001, relative risk 1.88, 95% confidence interval (CI) 1.16-4.78] were significantly higher in patients with f-QRS. A number value of f-QRS leads ≥2 yields sensitivity and specificity (85.3% and 86.7%, respectively) for predicting in-hospital all-cause mortality. Multivariable analysis showed that f-QRS (odds ratio: 1.041, 95% Cl: 1.021-1.192, p=0.040) were independently associated with in-hospital death. Conclusion: This study revealed that the presence of f-QRS in ECG is associated with higher in-hospital all-cause mortality in patients with severe COVID-19. f-QRS is an easily applicable simple indicator to predict the risk of death in these patients.

Background: The study was planned to assess potential differences in hypertension prevalance and hypertension related demographic properties in a urban area with relatively higher income and cultural population compared to national average. Methods: Field work was done by educated personel at Karşıyaka Municipality Building by one by one interviewing poll, blood pressure measurement, rhythm and body composition analysis in February 2014. Hypertension was defined as average systolic blood pressure ≥140 mmHg or average diastolic blood pressure ≥90 mmHg. Results: Out of total 1417 (627 males and 790 females) people enrolled, 780 people hypertensive(prevalence 55%). Hypertension prevalence in middle age group( age 35-65) was 46%, in geriatric age group(age>65) %79. 216 out of 780 hypertensive (27.7%) people were not aware of their disease. Ratio of people under antihypertensive treatment was 69.4% and ratio of people under control was 34.7%, whereas control rate was 50.1% in 541 patients who were aware of their diseases.Conclusions: Hypertension prevalances in our study were similar to PatenT2 trial prevalances, which were 46 % for middle age group and 78% for geriatric age group. Compared to PatenT 2 data, rate of hypertension awareness (54.7% vs 72.3%) and rate of being under treatment (47.5% vs 69.4%) were higher. Rate of controlled hypertension was a little big higher (28.7 % vs 34.7% )in our group, whereas control rates in aware and treated groups were similar (53.9 % and 50.1 %) in both study. Keywords: Hypertension, Prevalance, Awareness, Treatment

WOS: 000433285000010, PubMed ID: 28968197, Once-daily dosing of non-vitamin K antagonist oral anticoagulants (NOACs) may increase patient adherence to treatment but may also be associated with a higher risk of bleeding. In this study, we investigated the adherence to once-or twice-daily dosing of NOACs and the risk of bleeding in nonvalvular atrial fibrillation (NVAF) patients. This multicenter cross-sectional study, conducted between 1 September 2015 and 28 February 2016, included 2214 patients receiving NOACs for at least 3 months, due to NVAF. Patients receiving once-daily or twice-daily NOAC doses were 1: 1 propensity score matched for baseline demographic characteristics and the presence of other diseases. The medication adherence was assessed by the 8-item Morisky Medication Adherence Scale. Risk factors were investigated in relation to minor and major bleeding. The mean age of patients was 71 +/- 10 years, and 53% of the patients were women. The medication adherence was lower in patients receiving twice-daily NOAC doses compared to once-daily-dose group (47% versus 53%, p = 0.001), and there was no difference between the groups in terms of minor (15% versus 16%, p = 0.292) and major bleeding (3% versus 3%, p = 0.796). Independent risk factors for bleeding were non-adherence to medication (OR: 1.62, 95% CI: 1.23-2.14, p = 0.001), presence of 3 or more other diseases (OR: 10.3, 95% CI: 5.3-20.3, p < 0.001), and HAS-BLED (Hypertension, Abnormal renal and liver function, Stroke, Bleeding, Labile INR, Elderly, Drugs or alcohol) score (OR: 4.84, 95% CI: 4.04-5.8, p < 0.001). In summary, the once-daily dose of NOACs was associated with increased patient adherence to medication, while it was not associated with bleeding complications.

CETIN, NURULLAH/0000-0002-4158-5469 WOS: 000345117900002 PubMed: 25000542 Objective Hypertension has been reported to affect both the left and the right ventricular functions, but its effect on the coronary sinus has not been investigated. The aim of this study was to investigate the effect of systemic hypertension on the cardiac venous system by evaluating the coronary sinus strain (CSS). Methods One-hundred and twelve hypertensive patients without diabetes and 44 healthy individuals (the control group) were evaluated consecutively at the outpatient clinic and enrolled in the study. CSS was evaluated by echocardiography in all the participants before blood pressure evaluations. Twenty-four-hour ambulatory blood pressure monitoring enabled the study population to be divided into two groups: 52 patients with dipper pattern hypertension and 60 with nondipper pattern hypertension. Results Nondipper pattern patients had significantly lower values of CSS compared with the participants in the control group (140.8 +/- 54.2 and 193.9 +/- 48.1, P < 0.001). Similarly, dipper pattern patients had significantly lower values of CSS values compared with the controls (164 +/- 68.4 and 193.9 +/- 48.1, P = 0.036). On comparing the three groups, the CSS values showed a progressive decrease from normal individuals to dipper and nondipper hypertension patients. Correlation analysis indicated a positive correlation between the aortic strain and the CSS (r = 0.247, P = 0.002). There was a weak correlation between left ventricular mass and CSS (r = -164, P = 0.041). Conclusion Our study suggests that systemic hypertension may affect the cardiac venous system as well as the arterial system, which has been reported in many papers. The effect on the venous system may be more pronounced in nondipper pattern hypertension. Blood Press Monit 19: 320-326 (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

This study evaluated the early postoperative benefits of laparoscopic sleeve gastrectomy (LSG) on the left ventricular (LV) function and left atrial (LA) structural, mechanical, and electrical functions in severely obese patients.Thirty-two patients with severe obesity who were consecutively scheduled for LSG and 30 healthy controls were included in the study. LV global longitudinal strain (LGS), peak atrial longitudinal strain (PALS), and strain rates (S-Sr, E-Sr, and A-Sr) of the lateral and septal LA walls, and intra- and interatrial dyssynchrony periods for all subjects were evaluated using strain echocardiography. The measurements were repeated in patients 1 month after surgery.LGS of the LV was significantly depressed in the patient group compared with the control group (p 0.001). LA peak septal and lateral wall strain values were significantly lower in patients than in controls (both p values0.001). LA intra- and interatrial dyssynchrony periods were longer in patients than in controls (p = 0.012 and p = 0.004, respectively). LGS significantly improved after LSG (p 0.001). Significant reductions were noted in the LA antero-posterior diameter (p 0.001), LA volume index (LAVI, p = 0.001), and in the mitral velocity to the early diastolic velocity of the mitral annulus ratio (E/e' ratio, p = 0.046). The PALS of the septal and lateral LA walls significantly increased (p = 0.001 and p 0.001, respectively). S-Sr, E-Sr, and A-Sr values of the septal LA wall (p = 0.049, p 0.001, and p = 0.001, respectively) and the lateral LA wall (p = 0.009, p = 0.007, and p = 0.002, respectively) significantly improved postoperatively. Intra- and interatrial dyssynchrony significantly decreased (p = 0.001 and p 0.001, respectively). Weight loss positively correlated with changes in LGS (R = 0.39, p = 0.039), LAVI (R = 0.39, p = 0.034), intra-atrial dyssynchrony (R = 0.45, p = 0.021), interatrial dyssynchrony (R = 0.42, p = 0.038), septal LA wall peak strain (R = 0.44, p = 0.027), lateral LA wall peak strain (R = 0.46, p = 0.017), septal LA wall A-Sr (R = 0.43, p = 0.028), and lateral LA wall A-Sr (R = 0.46, p = 0.019). The comparison of postoperative findings of the patients with controls revealed that the LA diameter, both LA volume and volume index (LAVI), E/e' ratio, S-Sr and E-Sr of both lateral and septal LA walls, intra- and interatrial LA dyssynchrony of the patient group became similar to the control group (all p value0.05). Postoperative A-Sr values of both LA walls (both p value0.001) were higher in patients than controls.The benefits of LSG on LV and LA function may be observed even in the early postoperative phase. The resulting weight loss correlates with LV and LA reverse remodeling in severely obese patients.

Kliniğimize akut koroner sendrom tanısı ile yatırılan 56 yaşında kadın hastaya erken koroner girişim yapıldı. İşlem çevresi dönemde asetilsalisilik asit, klopidogrel ve heparini içeren antikoagülan ve antitrombotik tedavi veril- di. İzlemin erken döneminde şiddetli sırt ağrısı ve ardından hızlı ilerleme gösteren parapleji gelişti. Basıya neden olan spinal epidural hematom tanısı konduktan sonra hızlı bir şekilde ameliyata alındı ve dekompresyon yapıldı. Erken tanı ve erken cerrahi müdahale ile hasta hızlı bir şekilde sekelsiz olarak olarak iyileşti. Femoral bölgeden girişim ya- pılan hastalarda uzun süre aynı pozisyonda yatmaya bağlı gelişen sırt ağrıları girişimsel kardiyologların sık karşılaştı- ğı bir durumdur. Spontan spinal epidural hematom’un kli- nik başlangıcı da benzer şikayetler şeklindedir. Bu sebeple kardiyologların bu konuda dikkatli olmaları gerekir. Sunulan hastada olduğu gibi erken tanı ve erken müdahale oldukça iyi sonuçlar almamızı sağlayabilir., A 56-year-old female patient hospitalized with diagnosis of acute coronary syndrome underwent early cor- onary intervention. Anticoagulant and antithrombotic treat- ment was administered, including acetylsalicylic acid, clopi- dogrel, and heparin in periprocedural period. Severe back pain and rapidly progressing paraplegia developed in early period of follow-up. the patient underwent surgery immedi- ately after diagnosis of spontaneous spinal epidural hema- toma (SSEH) causing pressure, and decompression was performed. the patient rapidly improved without recurrence through early diagnosis and early surgical intervention. A common problem encountered by interventional cardiolo- gists is back pain in patients who have undergone interven- tions in the femoral region and have lain in the same posi- tion for an extended period. Clinical onset of SSEH includes similar complaints, a fact of which cardiologists should be aware. Early diagnosis and early intervention may provide a good outcome, as is reported in the present case.

The Turkish novelist Hüzeyme Yeşim Koçak, had written a novel called Sarılmak (2011) and has won the 2011 professional writers union which called İLESAM and Akçağ publishing house award for best novel of the year. This novel includes an overview of the major cultural, political, social and religious events and trends in Turkey in the 1970s. Hüzeyme Yeşim Koçak’ın, Sarılmak ( Ankara 2011) adlı romanı, bireysel ve evrensel yapılardan oluşan iki paralel unsur üzerine kurgulanmış. Yüzey yapıda beş kişilik bir ailenin, evin hanımının hastalığından kaynaklanan sıkıntılı, dramatik ve trajik hayatı, derin yapıda ise 1970’li yıllar Türkiye’sinin siyasi, kültürel ve toplumsal değişim sancılarının değişik toplumsal kesitlerin gündelik yaşantılarındaki ve bakış açılarındaki tezada dayalı olarak sergilenmesi vardır.

There is no literature which deals with historicaltopics during the Servet-i Fünun period. Because writerswho had gathered around "Servet-i Fünun" journal wereopposite religious and historical topics. in addition theywere joined Realism movement. But when the Servet-iFünun period was over, they started to mention historicaltopics

İstiklal Savaşından sonra yeni doğan Türkiye Cumhuriyetinin millî marşını seçmek için ülke çapında bir yarışma düzenlenmişti. Yarışmaya toplam 724 şiir katıldı. İstiklal Marşı, “bağımsızlık marşı” demektir ve Türk millî marşıdır. Bu marş Mehmet Akif Ersoy tarafından yazıldı ve 12 Mart 1921’de Türkiye Büyük Millet Meclisi tarafından resmen kabul edildi, born Turkish Republic after the Turkish war of independence. A total of 724 poems were submitted to this event. The original Turkish National Anthem the 10-verse poem (Istiklal Marsi in Turkish, meaning the´Independence March’), was written by Mehmet Akif Ersoy and officially adopted on March 12, 1921 by the Turkish Grand National Assembly

Objective Evaluation of the long-term effects of continuous positive airway presure (CPAP) on mean heart rate and left ventricular systolic and diastolic parameters in obstructive sleep apnea syndrome (OSAS) using conventional and tissue Doppler techniques. Methods This prospective cohort study is designed to evaluate the long-term effects of CPAP treatments in normotensive OSAS patients. Initially 40 patients aged from eighteen to fifty five with documented OSAS syndrome were evaluated within one month of CPAP treatment. All had high self-reported compliance with treatment. From the latter, 21 patients with uninterrupted CPAP therapy (for at least 5 years, 5 hours per day) were included in the study and further evaluated with treatment. The left ventricular systolic function was assessed on apical four- chamber view using modified Simpson method and diastolic function was evaluated with classic transmitral pulsed and tissue Doppler techniques. Paired t test and Wilcoxon signed rank test had been used to compare the clinical and echocardiography data before and after treatment period. Results A comparison of values assessed after one month and after 5 years of CPAP therapy, revealed a significant increase in the acceleration time(AT) Em/Am ratio and ejection time (ET) (AT: p=0.04; Em/Am ratio p=0.03 ET: p=0.04) while a significant decrease was observed on deceleration time (DT), isovolumetric relaxation time (IRT), myocardial performance index (MPI), mitral regurgitation (MR) and 24 hour mean heart rate (HR) in all subjects (DT: p=0.02; IVRT: p=0,04; MPI: p=0,01; MR: p≤0.001; HR: p=0.004). Conclusion We observed a significant improvement in the left ventricular systolic and diastolic function and a significant decrease of 24-hour heart rate and mitral regurgitation with unchanged ejection fraction of the left ventricle with long-term CPAP treatment similar to short-term treatment studies. The long-term maintenance of the beneficial effect of CPAP throughout the 5 year long-term treatment can be one of the pathophysiologic mechanisms that may explain the decrease of cardiovascular mortality observed with long-term CPAP therapy in OSAS patients.

Objective: Evaluation of the long-term effects of continuous positive airway presure (CPAP) on mean heart rate and left ventricular systolic and diastolic parameters in obstructive sleep apnea syndrome (OSAS) using conventional and tissue Doppler techniques. Methods: This prospective cohort study is designed to evaluate the long-term effects of CPAP treatments in normotensive OSAS patients. Initially 40 patients aged from eighteen to fifty five with documented OSAS syndrome were evaluated within one month of CPAP treatment. All had high self-reported compliance with treatment. From the latter, 21 patients with uninterrupted CPAP therapy (for at least 5 years, 5 hours per day) were included in the study and further evaluated with treatment. The left ventricular systolic function was assessed on apical four- cham- ber view using modified Simpson method and diastolic function was evaluated with classic transmitral pulsed and tissue Doppler techniques. Paired t test and Wilcoxon signed rank test had been used to compare the clinical and echocardiography data before and after treatment period. Results: A comparison of values assessed after one month and after 5 years of CPAP therapy, revealed a significant increase in the acceleration time(AT) Em/Am ratio and ejection time (ET) (AT: p=0.04; Em/Am ratio p=0.03 ET: p=0.04) while a significant decrease was observed on decel- eration time (DT), isovolumetric relaxation time (IRT), myocardial performance index (MPI), mitral regurgitation (MR) and 24 hour mean heart rate (HR) in all subjects (DT: p=0.02; IVRT: p=0,04; MPI: p=0,01; MR: p≤0.001; HR: p=0.004). Conclusion: We observed a significant improvement in the left ventricular systolic and diastolic function and a significant decrease of 24-hour heart rate and mitral regurgitation with unchanged ejection fraction of the left ventricle with long-term CPAP treatment similar to short-term treatment studies. The long-term maintenance of the beneficial effect of CPAP throughout the 5 year long-term treatment can be one of the pathophysiologic mechanisms that may explain the decrease of cardiovascular mortality observed with long-term CPAP therapy in OSAS patients.

29th Turkish Cardiology Congress of the Turkish-Society-of-Cardiology (TSC) with International Participation -- OCT 26-29, 2013 -- Antalya, TURKEY WOS: 000329858400203 … Turkish Soc Cardiol

29th Turkish Cardiology Congress of the Turkish-Society-of-Cardiology (TSC) with International Participation -- OCT 26-29, 2013 -- Antalya, TURKEY WOS: 000329858400209 … Turkish Soc Cardiol

Yeni Osmanlı Târîh-i Edebiyyâtı adlı eser, Köprülü-zâde Mehmet Fuat ve Şehabeddin Süleyman tarafından ortaklaşa hazırlanmıştır. Bu eser, pek çok bakımdan bilimsel bir edebiyat tarihi örneğidir, The literature history, called Yeni Osmanlı Târîh-i Edebiyyâtı is arranged jointly by Köprülü-zâde Mehmet Fuat and Şehabeddin Süleyman. This work is a scientific research example, from the many viewpoints of literature history

Ali Ekrem Bolayır ’ın Türk edebiyatı tarihi ile ilgili Tarih-i Edebiyyât-ı Osmâniyye (1910) adlı eseri, ciddi bir edebiyat tarihçiliği yöntemine sahip değildir. Belli bir yöntemi olmayan bir ders kitabı niteliğindedir, This study argues that ‘Ottoman Literature History, by Ali Ekrem Bolayır , has several methodological problems and it is insufficient as a work of science. However, it can be considered as a textbook for those who study the history of otoman literature

Sahabeddin Suleyman (1885-1919), a member of Fecr-i Ati generation, composed many works in the field of aesthetics, pedagogics and history of literature along with story, play, prose, poetry and anthology. In this study, Sahabeddin Suleyman’s History of Ottoman Literature (1328) is explored within the context of literary-historical approach.