Search

Your search keyword '"Nurmi, Tarja"' showing total 274 results
Start Over Author "Nurmi, Tarja"
274 results on '"Nurmi, Tarja"'

6. Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies

Author

Wu, Jason H Y, Marklund, Matti, Imamura, Fumiaki, Tintle, Nathan, Ardisson Korat, Andres V, de Goede, Janette, Zhou, Xia, Yang, Wei-Sin, de Oliveira Otto, Marcia C, Kröger, Janine, Qureshi, Waqas, Virtanen, Jyrki K, Bassett, Julie K, Frazier-Wood, Alexis C, Lankinen, Maria, Murphy, Rachel A, Rajaobelina, Kalina, Del Gobbo, Liana C, Forouhi, Nita G, Luben, Robert, Khaw, Kay-Tee, Wareham, Nick, Kalsbeek, Anya, Veenstra, Jenna, Luo, Juhua, Hu, Frank B, Lin, Hung-Ju, Siscovick, David S, Boeing, Heiner, Chen, Tzu-An, Steffen, Brian, Steffen, Lyn M, Hodge, Allison, Eriksdottir, Gudny, Smith, Albert V, Gudnason, Vilmunder, Harris, Tamara B, Brouwer, Ingeborg A, Berr, Claudine, Helmer, Catherine, Samieri, Cecilia, Laakso, Markku, Tsai, Michael Y, Giles, Graham G, Nurmi, Tarja, Wagenknecht, Lynne, Schulze, Matthias B, Lemaitre, Rozenn N, Chien, Kuo-Liong, Soedamah-Muthu, Sabita S, Geleijnse, Johanna M, Sun, Qi, Harris, William S, Lind, Lars, Ärnlöv, Johan, Riserus, Ulf, Micha, Renata, and Mozaffarian, Dariush

Published
2017
Full Text
View/download PDF

19. Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial : a randomized controlled trial

Author

Virtanen, Jyrki K., Nurmi, Tarja, Aro, Antti, Bertone-Johnson, Elizabeth R., Hyppönen, Elina, Kröger, Heikki, Lamberg-Allardt, Christel, Manson, JoAnn E., Mursu, Jaakko, Mäntyselkä, Pekka, Suominen, Sakari, Uusitupa, Matti, Voutilainen, Ari, Tuomainen, Tomi-Pekka, Hantunen, Sari, Virtanen, Jyrki K., Nurmi, Tarja, Aro, Antti, Bertone-Johnson, Elizabeth R., Hyppönen, Elina, Kröger, Heikki, Lamberg-Allardt, Christel, Manson, JoAnn E., Mursu, Jaakko, Mäntyselkä, Pekka, Suominen, Sakari, Uusitupa, Matti, Voutilainen, Ari, Tuomainen, Tomi-Pekka, and Hantunen, Sari

Abstract

BACKGROUND: Vitamin D insufficiency is associated with risk of cardiovascular diseases (CVD) and cancer in observational studies, but evidence for benefits with vitamin D supplementation is limited. OBJECTIVES: To investigate the effects of vitamin D3 supplementation on CVD and cancer incidence. DESIGN: The study was a 5-year randomized placebo-controlled trial among 2495 male participants ≥ 60 years and post-menopausal female participants ≥ 65 years from a general Finnish population who were free of prior CVD or cancer. The study had three arms: placebo, 1600 IU/day or 3200 IU/day vitamin D3. Follow-up was by annual study questionnaires and national registry data. A representative sub-cohort of 551 participants had more detailed in-person investigations. The primary endpoints were incident major CVD and invasive cancer. Secondary endpoints included the individual components of the primary CVD endpoint (myocardial infarction, stroke, and CVD mortality), site-specific cancers and cancer death. RESULTS: During the follow-up, there were 41 (4.9%), 42 (5.0%) and 36 (4.3%) major CVD events in the placebo, 1600 IU/d (vs. placebo: hazard ratio (HR), 0.97;95% CI, 0.63,1.49; P = 0.89), and 3200 IU/d (HR, 0.84;95% CI, 0.54,1.31; P = 0.44) arms, respectively. Invasive cancer was diagnosed in 41 (4.9%), 48 (5.8%) and 40 (4.8%) participants in the placebo, 1600 IU/d (HR, 1.14;95% CI, 0.75,1.72; P = 0.55), and 3200 IU/d (HR, 0.95;95% CI, 0.61,1.47; P = 0.81) arms, respectively. There were no significant differences in the secondary endpoints or total mortality. In the sub-cohort, the mean (standard deviation) baseline serum 25-hydroxyvitamin D concentration was 75 (18) nmol/L. After 12 months, the concentrations were 73 (18) nmol/L, 100 (21) nmol/L and 120 (22) nmol/L in the placebo, 1600 IU/d and 3200 IU/d arms, respectively. CONCLUSIONS: Vitamin D3 supplementation did not lower the incidence of major CVD events or invasive cancer among older adults, possibly due to sufficient v, CC BY 4.0Virtanen, Jyrki K.(corresponding author)Published: 04 January 2022This study was supported by funding from the Academy of Finland (#137826), University of Eastern Finland, Juho Vainio Foundation, Medicinska Understödsföreningen Liv och Hälsa, Finnish Foundation for Cardiovascular Research, Finnish Diabetes Research Foundation, and Finnish Cultural Foundation.

Published
2022
Full Text
View/download PDF

21. Elevated Circulating LDL Phenol Levels in Men Who Consumed Virgin Rather Than Refined Olive Oil Are Associated with Less Oxidation of Plasma LDL ,

Author

de la Torre-Carbot, Karina, Chávez-Servín, Jorge L., Jaúregui, Olga, Castellote, Ana I., Lamuela-Raventós, Rosa M., Nurmi, Tarja, Poulsen, Henrik E., Gaddi, Antonio V., Kaikkonen, Jari, Zunft, Hans-Franz, Kiesewetter, Holger, Fitó, Montserrat, Covas, María-Isabel, and López-Sabater, M. Carmen

Published
2010
Full Text
View/download PDF

30. The Dietary Polyphenol Metabolite Enterolactone Activates Estrogen Signaling in Reproductive and Non-Reproductive Tissues and Regulates the Expression of Circadian Genes in Mice

Author

Damdimopoulou, Pauliina, primary, Nurmi, Tarja, additional, Salminen, Anu, additional, Yli-Heikkila, Maria, additional, Damdimopoulos, Anastasios E, additional, Poutanen, Matti, additional, van der Saag, Paul, additional, Strauss, Leena, additional, and Makela, Sari, additional

Published
2011
Full Text
View/download PDF

31. Rye bread in the diet of pigs enhances the formation of enterolactone and increases its levels in plasma, urine and feces

Author

Knudsen, Knud Erik Bach, Serena, Anja, Kjaer, Anna Kirstin Bjornback, Tetens, Inge, Heinonen, Satu-Maarit, Nurmi, Tarja, and Adlercreutz, Herman

Subjects
Metabolism -- Research, Nutrition -- Research, Rye, Swine -- Food and nutrition, Food/cooking/nutrition
Abstract

To obtain new insight into the quantitative and qualitative metabolism of rye and wheat lignans, we performed three series of experiments with catheterized pigs. Two diets with similar levels of dietary fiber and macronutrients but with contrasting levels of plant lignans (isolariciresinol, lariciresinol, matairesinol, pinoresinol, secoisolariciresinol and syringaresinol) were prepared from rye (high in lignans) and wheat (low in lignans) soft and crisp breads. In two series of experiments we quantified the uptake from the gut of enterolactone in four pigs fitted with catheters in the portal vein and mesenteric artery and with an ultrasonic flow probe attached to the portal vein to monitor the blood flow. In a third study with six pigs, we quantified the bioavailability of the plant lignans that can be converted to enterolactone (lariciresinol, matairesinol, pinoresinol, secoisolariciresinol and syringaresinol) and the concentration in the peripheral blood. Plant and mammalian lignans in diets and stool were analyzed by isotope dilution gas chromatography--mass spectrometry and enterolactone in plasma and urine determined by time-resolved fluoroimmunoassay. There was a significantly higher formation of enterolactone in pigs fed the rye diet, and higher fecal and urinary excretion and circulating levels of mammalian lignans than in pigs fed the wheat diet. The conversion of mammalian lignan precursors to enterolactone was 48% with the wheat diet and 60% with the rye diet. Mammalian lignans are absorbed by passive diffusion from the large intestine and a substantial fraction of the absorbed mammalian lignans undergoes enterohepatic circulation, resulting in low diurnal variation in plasma levels of enterolactone. KEY WORDS: * catheterized pigs * enterolactone * lignans * metabolism

Published
2003

40. Process-induced changes on bioactive compounds in whole grain rye

Author

Liukkonen, Kirsi-Helena, Katina, Kati, Wilhelmsson, Annika, Myllymaki, Olavi, Lampi, Anna-Maija, Kariluoto, Susanna, Piironen, Vieno, Heinonen, Satu-Maarit, Nurmi, Tarja, Adlercreutz, Herman, Peltoketo, Anna, Pihlava, Juha-Matti, Hietaniemi, Veil, and Poutanen, Kaisa

Published
2003

45. Competition Culture in Europe:2013 - 2016

Author

Menteth, Walter, Kristo, Saimir, Isopp, Anne, Turkusic Juric, Elsa, Vasileva, Aneta, Okamura, Osamu, Nurmi, Tarja, Heilmeyer, Florian, Phokaides, Petros, Magliozzi, Zaira, Scanlon, Emmett, Limani, Vjollca, Zibarte, Ieva, Leitanaite, Ruta, Jansen, Cilly, van 't Klooster, Indira, Skajaa, Joakim, Trammer, Hubert, van 't Klooster, Indira, Jansen, Cilly, and de Jager, Margot

Subjects
Europe, case study, competitions, architecture, design contests, design, competition programming, survey, Building and Construction, Architecture and Interior Design
Abstract

Conditions in architectural design around the world call for new solutions in which younger generations are engaged and how social challenges can be physically implemented. Sustainability, energy, climate resilience, water safety, mobility, population, vacancy levels health, food, refugees and terrorism need to be addressed. The built environment can be the consequence of a well considered process, baseed on ambitious collaborative concepts. Competitions, or more specifically design contests, could offer new solutions.

Published
2017

50. Omega-6 fatty acid biomarkers and incident type 2 diabetes : pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies

Author

Wu, Jason H. Y., Marklund, Matti, Imamura, Fumiaki, Tintle, Nathan, Korat, Andres V. Ardisson, de Goede, Janette, Zhou, Xia, Yang, Wei-Sin, Otto, Marcia C. de Oliveira, Kroger, Janine, Qureshi, Waqas, Virtanen, Jyrki K., Bassett, Julie K., Frazier-Wood, Alexis C., Lankinen, Maria, Murphy, Rachel A., Rajaobelina, Kalina, Del Gobbo, Liana C., Forouhi, Nita G., Luben, Robert, Khaw, Kay-Tee, Wareham, Nick, Kalsbeek, Anya, Veenstra, Jenna, Luo, Juhua, Hu, Frank B., Lin, Hung-Ju, Siscovick, David S., Boeing, Heiner, Chen, Tzu-An, Steffen, Brian, Steffen, Lyn M., Hodge, Allison, Eriksdottir, Gudny, Smith, Albert V., Gudnason, Vilmunder, Harris, Tamara B., Brouwer, Ingeborg A., Berr, Claudine, Helmer, Catherine, Samieri, Cecilia, Laakso, Markku, Tsai, Michael Y., Giles, Graham G., Nurmi, Tarja, Wagenknecht, Lynne, Schulze, Matthias B., Lemaitre, Rozenn N., Chien, Kuo-Liong, Soedamah-Muthu, Sabita S., Geleijnse, Johanna M., Sun, Qi, Harris, William S., Lind, Lars, Arnlov, Johan, Risérus, Ulf, Micha, Renata, Mozaffarian, Dariush, Wu, Jason H. Y., Marklund, Matti, Imamura, Fumiaki, Tintle, Nathan, Korat, Andres V. Ardisson, de Goede, Janette, Zhou, Xia, Yang, Wei-Sin, Otto, Marcia C. de Oliveira, Kroger, Janine, Qureshi, Waqas, Virtanen, Jyrki K., Bassett, Julie K., Frazier-Wood, Alexis C., Lankinen, Maria, Murphy, Rachel A., Rajaobelina, Kalina, Del Gobbo, Liana C., Forouhi, Nita G., Luben, Robert, Khaw, Kay-Tee, Wareham, Nick, Kalsbeek, Anya, Veenstra, Jenna, Luo, Juhua, Hu, Frank B., Lin, Hung-Ju, Siscovick, David S., Boeing, Heiner, Chen, Tzu-An, Steffen, Brian, Steffen, Lyn M., Hodge, Allison, Eriksdottir, Gudny, Smith, Albert V., Gudnason, Vilmunder, Harris, Tamara B., Brouwer, Ingeborg A., Berr, Claudine, Helmer, Catherine, Samieri, Cecilia, Laakso, Markku, Tsai, Michael Y., Giles, Graham G., Nurmi, Tarja, Wagenknecht, Lynne, Schulze, Matthias B., Lemaitre, Rozenn N., Chien, Kuo-Liong, Soedamah-Muthu, Sabita S., Geleijnse, Johanna M., Sun, Qi, Harris, William S., Lind, Lars, Arnlov, Johan, Risérus, Ulf, Micha, Renata, and Mozaffarian, Dariush

Abstract

Background The metabolic effects of omega-6 polyunsaturated fatty acids (PUFAs) remain contentious, and little evidence is available regarding their potential role in primary prevention of type 2 diabetes. We aimed to assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabetes. Methods We did a pooled analysis of new, harmonised, individual-level analyses for the biomarkers linoleic acid and its metabolite arachidonic acid and incident type 2 diabetes. We analysed data from 20 prospective cohort studies from ten countries (Iceland, the Netherlands, the USA, Taiwan, the UK, Germany, Finland, Australia, Sweden, and France), with biomarkers sampled between 1970 and 2010. Participants included in the analyses were aged 18 years or older and had data available for linoleic acid and arachidonic acid biomarkers at baseline. We excluded participants with type 2 diabetes at baseline. The main outcome was the association between omega-6 PUFA biomarkers and incident type 2 diabetes. We assessed the relative risk of type 2 diabetes prospectively for each cohort and lipid compartment separately using a prespecified analytic plan for exposures, covariates, effect modifiers, and analysis, and the findings were then pooled using inverse-variance weighted meta-analysis. Findings Participants were 39 740 adults, aged (range of cohort means) 49-76 years with a BMI (range of cohort means) of 23.3-28.4 kg/m(2), who did not have type 2 diabetes at baseline. During a follow-up of 366 073 person-years, we identified 4347 cases of incident type 2 diabetes. In multivariable-adjusted pooled analyses, higher proportions of linoleic acid biomarkers as percentages of total fatty acid were associated with a lower risk of type 2 diabetes overall (risk ratio [RR] per interquintile range 0.65, 95% CI 0.60-0.72, p<0.0001; I-2=53.9%, p(heterogeneity) = 0.002). The associations between linoleic acid biomarkers and type 2 diabetes were generally similar in d

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results