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1. Test–retest reliability of putting-related variables in medium-to-high handicap golf players

Author: Xavier García-Massó, Israel Villarrasa-Sapiña, Nuria Ortega-Benavent, Sergio Montalt-García, and José L. Toca-Herrera
Subjects: Reliability, Putting, Performance assessment, Accelerations, Medicine, Science
Abstract: Abstract This manuscript aims to study the reliability of different variables related to performance and acceleration during the golf putt in players with medium-to-high handicaps and to determine the number of attempts necessary to find reliable values for these variables. Eight males and two females [55.67 (13.64) years, 78.4 (11.4) kg, 1.75 (7.95) m] participated in two experimental sessions separated by one week. In these sessions, they performed three blocks of 10 putts trying to stop the golf ball at the center of a dartboard painted 2 m away. The performance was assessed depending on the area of the dartboard where the ball stopped, and the acceleration signals were acquired using the Xsens Dot. The results showed that to evaluate performance, 18 trials were necessary to reach reliable values using the 0–10 scoring system, and 28 trials were necessary for the 0–3 scoring system. Regarding the reliability of the accelerometer-related variables, 7 attempts were necessary to obtain good-to-excellent reliability values for most of the variables. It could be concluded that putting in medium-to-high handicap golf players can be reliably measured using the abovementioned protocol.
Published: 2024
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2. Enhancing Ecological Validity: Virtual Reality Assessment of Executive Functioning in Children and Adolescents with ADHD

Author: Dulce Romero-Ayuso, Antonio del Pino-González, Antonio Torres-Jiménez, Jorge Juan-González, Francisco Javier Celdrán, María Constanza Franchella, Nuria Ortega-López, José Matías Triviño-Juárez, Ana Garach-Gómez, Luisa Arrabal-Fernández, Inmaculada Medina-Martínez, and Pascual González
Subjects: assessment, executive functions, ADHD, virtual reality, activities of daily living, Pediatrics, RJ1-570
Abstract: Background: SmartAction-VR uses virtual reality to simulate daily life tasks and assess cognitive performance based on the multi-errand paradigm. This study explored whether this new task could provide insights into the executive functioning of children and adolescents with ADHD in their everyday activities. Methods: A cross-sectional study was conducted between November 2021 and December 2022. It consisted of one session and was divided into two parts (cognitive tests; and SmartAction-VR). The sample comprised 76 children and adolescents with a median age (IQR) of 13 (11–14) years and an age range of 9–17 years. Of these participants, 60.50% (n = 46) were males. Out of this sample, 40 participants were in the ADHD group and 36 were in the neurotypical group. The following instruments were used: Waisman Activities of Daily Living Scale, Assessment of Sensory Processing and Executive Functioning, Pediatric Simulator Disease Questionnaire, Digit span subtest, Stroop test, NEPSY-II Subtest of Auditory Attention and Cognitive Flexibility, Trail Making Test, Zoo Map Test, and SmartAction-VR. Results: The ADHD group demonstrated lower accuracy (U = 406, p = 0.010), higher values for total errors (U = 292, p = 0.001), more commissions (U = 417, p = 0.003), new actions (U = 470, p = 0.014), and forgetting actions (U = 406, p = 0.010), as well as fewer perseverations compared to the neurotypical group (U = 540.5, p = 0.029). Additionally, participants who forgot more actions were found to have lower independence in daily life (r = −0.281, p = 0.024). Conclusions: The correlations between the results of SmartAction-VR and activities of daily living, as well as cognitive tests, suggest that this new task could be useful for evaluating executive functioning in daily life.
Published: 2024
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3. Cognitive CAMSA: an ecological proposal to integrate cognitive performance into motor competence assessment

Author: Sergio Montalt-García, Isaac Estevan, Jorge Romero-Martínez, Nuria Ortega-Benavent, Israel Villarrasa-Sapiña, Cristina Menescardi, and Xavier García-Massó
Subjects: motor competence, cognitive performance, physical literacy, dual-task, adolescent profiles, Psychology, BF1-990
Abstract: PurposeTo profile the participants using a system of self-organizing maps (SOM) based on their motor and cognitive performance during a dual-task version of the Canadian Agility and Movement Skill Assessment (Cognitive CAMSA).MethodsA total of 169 secondary school students (39.3% girls) volunteered to participate. The original CAMSA, cognitive CAMSA, the Corsi and Digit Span tests were used to assess (a) motor competence, (b) motor competence with cognitive load, and (c) cognitive performance, respectively. SOMs and the k-means clustering algorithm were used to establish the adolescents’ dual-task performance profiles.ResultsIncluding decision making based on verbal and visual cues in the original CAMSA significantly increased the participants’ total scores but also the time required to complete the test, while the skill score remained unchanged. However, not all the participants showed changes in their performance in the same direction during the cognitive CAMSA. Person-centered analyses by SOMs and k-means clustering identified six performance profiles with variations in the cognitive, motor skill, and time scores (H5 = 146.15, H5 = 102.68, and H5 = 108.07, respectively; all p
Published: 2023
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4. Dashboard para el análisis de la rentabilidad de las estrategias de comercialización de café en sociedades de caficultores

Author: Selene Reyes Mendoza, Edna Araceli Romero Flores, Oscar Yahevh Carrera Mora, and Nuria Ortega Petterson
Subjects: dashboard, caficultores, comercialización del café, rentabilidad, Social sciences (General), H1-99
Abstract: El objetivo es determinar el impacto de un dashboard para interpretar la rentabilidad de las estrategias de comercialización de café de caficultores sin conocimientos financieros. Para comprobar la hipótesis, la metodología fue una investigación empírica con enfoque mixto y un diseño transversal a través del estudio de caso, realizando el análisis en cuatro fases; la principal consistió en una solución a priori que detonó el desarrollo de un dashboard basado en web. Este se implementó en una sociedad de solidaridad social de caficultores. Los resultados muestran que la rentabilidad general es del 0.01. Lo anterior evidencia que los caficultores desconocen la rentabilidad de su negocio, como consecuencia de estrategias comerciales que no están siendo atendidas por no saber interpretar los datos financieros. Asimismo, se identifican deficiencias financieras y de conocimiento de los caficultores. Para concluir, esta herramienta influye significativamente en la orientación empresarial a partir del análisis de la rentabilidad del negocio.
Published: 2023
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5. A Classroom-Based Intervention to Promote Physical Literacy in Children: ALPHYL Study Protocol

Author: Isaac Estevan, Xavier García-Massó, Cristina Menescardi, Nuria Ortega-Benavent, Sergio Montalt-García, Jorge Romero-Martínez, Isabel Castillo, Octavio Álvarez, Ana Queralt, and Javier Molina-García
Subjects: physically active learning, childhood, physical activity, health, school, Psychology, BF1-990
Abstract: Physical literacy is crucial for children’s appropriate development and physical, social and mental health. In a school setting, class-based physical activity (PA) interventions are considered to be appropriate programs to foster PA participation and cognitive development. The purpose of this project, named the Active Learning in PHYsical Literacy (ALPHYL) study, was to describe a multicomponent classroom-based physically-active learning randomised control trial (RCT) in primary school children. The main purpose was to promote children’s physical literacy, academic achievement and cognitive function. The ALPHYL study is mainly based on physical literacy, active school models and the Supportive, Active, Autonomous, Fair and Enjoyable principles. The ALPHYL is an 8–10-week RCT to be conducted in six primary schools (12 classes) in Valencia (Spain) and its metropolitan area. Schools will be randomly assigned to the intervention or waiting-list control group. After a 30 h in-person training course for teachers and weekly meetings in the three months of resource preparation, the ALPHYL intervention will be conducted in physical education (PE) and non-PE lessons by teachers. The intervention consists of at least three daily sessions of physically active learning in addition to model-based PE teaching. Its feasibility will be evaluated weekly according to the Reach, Effectiveness, Adoption, Implementation and Maintenance framework. To assess its effectiveness, a pre-test, post-test and retention (8–10 weeks post-intervention) with primary outcomes (i.e., PA level, motor competence, perceived motor competence and PL, motivation, perceived social support, academic achievement and cognitive function), secondary outcomes and covariates will be collected.
Published: 2023
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6. Persistence of SARS-CoV-2 total immunoglobulins in a series of convalescent plasma and blood donors

Author: M. Carmen Martin, Ana Jimenez, Nuria Ortega, Alba Parrado, Isabel Page, M. Isabel Gonzalez, and Lydia Blanco-Peris
Subjects: Medicine, Science
Abstract: Background The vast majority of COVID-19 cases both symptomatic and asymptomatic develop immunity after COVID-19 contagion. Whether lasting differences exist between infection and vaccination boosted immunity is yet to be known. The aim of this study was to determine how long total anti-SARS-CoV2 antibodies due to past infection persist in peripheral blood and whether sex, age or haematological features can influence their lasting. Material and methods A series of 2421 donations either of SARS-CoV-2 convalescent plasma or whole blood from 1107 repeat donors from January 2020 to March 2021 was analysed. An automated chemiluminescence immunoassay for total antibodies recognizing the nucleocapsid protein of SARS-CoV-2 in human serum and plasma was performed. Sex, age, blood group, blood cell counts and percentages and immunoglobulin concentrations were extracted from electronic recordings. Blood donation is allowed after a minimum of one-month post symptom’s relapse. Donors were 69.7% males and their average age was 46. The 250 donors who had later donations after a positive one underwent further analysis. Both qualitative (positivity) and quantitative (rise or decline of optical density regarding consecutive donations) outcomes were evaluated. Results and discussion In 97.6% of donors with follow-up, anti-SARS-CoV-2 protein N total antibodies remained positive at the end of a follow-up period of 12.4 weeks median time (1–46, SD = 9.65) after the first positive determination. The blood group was not related to antibody waning. Lower lymphocyte counts and higher neutrophils would help predict future waning or decay of antibodies. Most recovered donors maintain their total anti-SARS-CoV-2 N protein antibodies for at least 16 weeks (at least one month must have been awaited from infection resolution to blood donation). The 10 individuals that could be followed up longer than 40 weeks (approximately 44 weeks after symptom’s relapse) were all still positive.
Published: 2022

7. Test–Retest Reliability of Task Performance for Golf Swings of Medium- to High-Handicap Players

Author: Israel Villarrasa-Sapiña, Nuria Ortega-Benavent, Gonzalo Monfort-Torres, Jesús Ramon-Llin, and Xavier García-Massó
Subjects: biomechanics, reliability, measurement, methodology, performance, Chemical technology, TP1-1185
Abstract: Background: Golf swing performance in medium- to high-handicap players must be reliably measured to use this variable in both research studies and in applied settings. Nevertheless, there are no studies published on this topic and test–retest evidence is only available for low-handicap players. The aim of this study was to determine the number of attempts necessary to obtain a reliable measurement protocol for swing performance variables in medium- to high-handicap players. Methods: Ten amateur players (55.67 (13.64) years, 78.4 (11.4) kg, 1.75 (7.95) m) took part in a test–retest study in two experimental sessions one week apart. In each one, fifteen swings with a six iron and a driver were evaluated with a 3D Doppler tracking golf radar. Results: The results showed that variables related to side carry could not be reliably measured in medium- to high-handicap players in only fifteen trials (ICC < 0.26, SEM > 12.05 m and MDC > 33.41 m). The rest of the performance variables related to the club and ball trajectories could be reliably measured with a 3D Doppler radar with between seven and ten swings. Conclusions: At least seven swings are recommended for the driver and ten for the six iron to measure golf swing performance.
Published: 2022
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8. La deuda y el cuerpo en el deporte de alto rendimiento

Author: Nuria Ortega
Subjects: deporte, deuda, biopolítica, Communication. Mass media, P87-96
Abstract: Lazzarato (2013) propone el dispositivo de la deuda como mecanismos de control de la subjetividad mediante la culpa y la responsabilidad. La deuda, como nuevo eje en el que se estructura la gobernanza, subordina nuevas relaciones de poder desterritorializadas. Este dispositivo de sujeción se expande y disciplina las prácticas y los valores éticos y morales a nivel global, en tanto que modifica las estructuras de las relaciones de poder generando un nuevo mecanismo de explotación capitalista. Esta ponencia se propone pensar algunos lineamientos en relación a la deuda y al cuerpo, usando como ejemplo el mundo deportivo del alto rendimiento. Allí en donde el cuerpo se muestra en su mayor esplendor, la deuda regula y habilita la intervención constante de lo tecnocientífico para mejorar el rendimiento de los cuerpos atléticos competitivos en busca del record imposible, de una naturaleza que nunca apareció como tal, pero que debe ser restituida.
Published: 2015

9. National observational study about the surgical treatment of anal fistula: Does the kind of hospital modify the results?

Author: Soria, Javier Espinosa, Orejuela, Jordi Seguí, Corral, Natalia Gutiérrez, Agundez, María Carmona, Pérez, David Saavedra, Mejía, Helga Calvaienen, Segura, Marta Barros, Pellino, Gianluca, León, Gerardo Rodríguez, Salido, Andrea Jiménez, Sánchez, Tatiana Gómez, Ortiz, Susana Roldán, Gutiérrez, Luis Eloy Cantero, Pazos, Natalia Suarez, Poch, Lidia Cristóbal, López, Juan Ramón Gómez, Sánchez, Pablo Méndez, Veiga, Pilar Fernández, Rodríguez, Victoria Erene Flores, Valderrama, Oscar Cano, Iribarren, Enrique Moncada, Torrecilla, Nuria Ortega, Acosta, Alberto Carrillo, Illescas, Cristina Plata, Vigil, Jose Luis Diez, Martínez, Estefanía Laviano, Martos, María Beltrán, Zafra, David Ambrona, Farré, Silvia Pérez, Pé rez, David Díaz, Herrera, Ana Belén Gallardo, Viejo, Elena, Jiménez, Juan Ocaña, Núñez, Jordi Núñez, Bonito, Alba Correa, Marcos, Elena Bermejo, Bocanegra, Marta González, Martínez, Alicia Ferrer, Fernández, Irene Mirón, Sánchez-Migallón, Elena González, Solano Palao, María Teresa, Ros, Emilio Peña, Cao, Inés Aldrey, Rodríguez, Carlenny Suero, Maderuelo, Victoria, Amo, Aroa Abascal, Catena, Juan Cintas, La Villa, María del Campo, Ramo, Mahur Esmaili, Benítez, Javier Broeckhuizen, Barles, Ana Navarro, Sánchez, Luis Eduardo Pérez, Sánchez, Ana Soto, Jiménez, Nélida Díaz, González, Ana María Feria, Pina, Estefanía Domenech, Comesaña, Alejandro Ros, Coltell, Zutoia Balciscueta, Santiago, Leticia Pérez, Hernández, Luisa Paola Garzón, de Andrés Gómez, Alejandra, Abellán, Antonio Melero, Muriel, Jorge Sancho, Scheiding, Mónica Millán, Cholewa, Hanna, Iranzo, Marina Alarcón, Pelegri, Ana Fluixá, Miguel, Tamara Fernández, Machón, Natalia Ortega, Hernández, Natalia Alonso, Granero, Álvaro García, Taboada, Tatiana Civeira, Fernández, Yago Rojo, Cuellar, Jose Aurelio Navas, Castillo, Celia, Miguelañez, Isabel Pascual, Barbeitio, Sandra Dios, Díaz, María Luisa Reyes, Cabrera, Ana María García, Solís, Irene María Ramallo, Pérez, Teresa Pérez, Marín, Gabriel, Lillo, Aranzazu Calero, Guillén, Luis Sánchez, Noguera, Julia López, Pérez, Miguel Ángel, Cano-Valderrama, Oscar, Cerdán-Santacruz, Carlos, Fernández Veiga, Pilar, Fernández-Miguel, Tamara, García-Granero, Álvaro, Calderón, Teresa, and Reyes, María L.
Published: 2024
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10. Las infancias sonoras

Author: Nuria Ortega Riba and Nuria Ortega Riba
Published: 2022

11. BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α2B Antagonist

Author: Daniel Meibom, Jutta Meyer, Clemens-Jeremias von Buehler, Karl D. Collins, Stefanie Maassen, Kersten Matthias Gericke, Jörg Hüser, Joachim Mittendorf, Nuria Ortega Hernandez, Jens Schamberger, Jan Stampfuss, Alexander Straub, Afra Torge, Norbert Witowski, and Frank Wunder
Subjects: Drug Discovery, Molecular Medicine
Published: 2023

12. Aplicación de la metodología SIGMIL como modelo integral para el desarrollo estratégico del departamento de ecología municipal

Author: María Yonaina Rodríguez Aguirre, Edna Araceli Romero Flores, Fernando Aguirre Y Hernández, Nuria Ortega Petterson, and Eduardo Mael Sánchez Coronado
Abstract: En la actualidad garantizar un desarrollo continuo en las organizaciones no es trabajo fácil, es por ello que se deben establecer estrategias que permitan proteger la rentabilidad a futuro; en este sentido la metodología Sistema Integral de Gestión y Medición de Indicadores de logro (SIGMIL), es un sistema simple, sencillo y funcional que contribuye en la realización de planes integrales de desarrollo para las empresas de todo tipo, pero sobre todo para aquellas que por razones económicas no pueden pagar un consultor externo; tal es el caso del Departamento de Ecología Parques y Jardines del H. Ayuntamiento de Orizaba, Veracruz, que actualmente tiene a su cargo personal con la responsabilidad de mantener diversas áreas verdes, espacios públicos y educación ambiental; con la correcta aplicación de la metodología es posible estructurar el equipo de trabajo, determinar el plan de acción utilizando herramientas como brainstorming, el análisis y la elección; como resultado al trabajo previo se realizó el cuadro integral de mando, esta herramienta ayuda a medir la evolución del departamento como: los objetivos estratégicos, los resultados, las actividades etc., la contribución principal en el presente trabajo es marcar un antes y un después a partir de la aplicación prospectiva de los proyectos estratégicos con el fin de anticipar los cambios.
Published: 2022

13. DASHBOARD PARA EL ANÁLISIS DE LA RENTABILIDAD DE LAS ESTRATEGIAS DE COMERCIALIZACIÓN DE CAFÉ EN SOCIEDADES DE CAFICULTORES

Author: Mendoza, Selene Reyes, Flores, Edna Araceli Romero, Mora, Oscar Yahevh Carrera, and Petterson, Nuria Ortega
Subjects: comercialización del café, caficultores, dashboard, rentabilidad
Abstract: El objetivo es determinar el impacto de un dashboard para interpretar la rentabilidad de las estrategias de comercialización de café de caficultores sin conocimientos financieros. Para comprobar la hipótesis, la metodología fue una investigación empírica con enfoque mixto y un diseño transversal a través del estudio de caso, realizando el análisis en cuatro fases; la principal consistió en una solución a priori que detonó el desarrollo de un dashboard basado en web. Este se implementó en una sociedad de solidaridad social de caficultores. Los resultados muestran que la rentabilidad general es del 0.01, Lo anterior evidencia que los caficultores desconocen la rentabilidad de su negocio, como consecuencia de estrategias comerciales que no están siendo atendidas por no saber interpretar los datos financieros. Asimismo, se identifican deficiencias financieras y de conocimiento de los caficultores. Para concluir, esta herramienta influye significativamente en la orientación empresarial a partir del análisis de la rentabilidad del negocio., {"references":["Berisha-Namani, M. (2009). The role of information technology in small and medium sized enterprises in Kosova.","Paper presented at the Fulbright Academy 2009 Conference: Small Places Can Change the World.","www.fulbrightacademy.org/file_ depot/0-10000000/20000-30000/ 21647/folder/82430/ BerishaþPaperþITþinþSMEsþinþKos ovo","Besley, S. & Brigham, E. (2008). Fundamentos de administración financiera. México: Cengage Learning.","Block, S., Hirt, G. & Danielsen, B. (2013). Fundamentos de administración financiera. México: McGraw-Hill.","Brealey, R., Myers, S., y Allen, F. (2010). Principios de finanzas corporativas. México:McGraw-Hill.","Cuevas-Vargas, H., y Parga-Montoyab, N. (2022). How ICT usage affect frugal innovation in Mexican small firms. The mediating role of entrepreneurial orientation.","Procedia Computer Science 199 (1), 223-230. https://doi.org/10.1016/j. procs.2022.01.028","De la Hoz Suárez, B.; Ferrer, M. A., y De La Hoz Suárez, A. (2008). Indicadores de rentabilidad: herramientas para la toma decisiones financieras en hoteles de categoría media ubicados en Maracaibo. Revista de Ciencias Sociales, 14 (1), 88-109.","Emery D., Finnerty, J., y Stowe, J. (2004). Fundamentos de administración financiera. México: Pretice Hall.","Eschker, E., Gold, G. y Lane, M.D. (2017). \"Rural entrepreneurs: what are the best indicators of their success?\", Journal of Small Business and Enterprise Development, Vol. 24 No. 2, pp. 278-296. https://doi. org/10.1108/JSBED-07-2016-0112 Esuh Ossai-Igwe, L., y Minai, M.S. (2011).","The conceptual framework of entrepreneur and self 289 management\", International Journal of Business and Social Science, Vol. 2 No. 20, pp. 180-185.","García, O.L. (2011). Administración financiera: Fundamentos y aplicaciones. Colombia: Prensa Moderna Impresores.","Gitman, L., y Zutter, C. (2012). Principios de administración financiera. México: Pearson Educación.","Guajardo, G., y Andrade, N. (2008). Contabilidad financiera. México: McGraw-Hill.","Lutsak, N. (2011). Administración financiera. Ecuador: Editorial de la universidad técnica particular de Loja.","Nica, I; Chirita, N., y Ionescu, S. (2021). Using of KPIs and Dashboard in the analysis of Nike company's performance management. Theoetical and Applied Economic, 23 (1), 61-84.","Nicoleta, C. (2014). The dashboard – conceptual dimensions and evolutions. Economics, Management & Financial Markets, 9 (1), 448-456.","Perdomo, A. (2008). Elementos básicos de administración financiera. México: Cengage Learning.","Robles, C. (2012). Fundamentos de administración financiera. México: Red tercer milenio.","Robles, H. (2011). Los Productores de Café en México: Problemática y Ejercicio del Presupuesto. Mexican Rural Development Research Reports. Recuperado de: https:// www.wilsoncenter.org/sites/ default/files/media/documents/ publication/Hector_Robles_Cafe_ Monografia_14.pdf","Tauringana, V., y Adjapong Afrifa, G. (2013). \"The relative importance of working capital management and its components to SMEs' profitability\", Journal of Small Business and Enterprise Development, Vol. 20 No. 3, pp. 453-469. https://doi. org/10.1108/JSBED-12-2011-0029","Van Horne, J., y Wachowicz, J. (2010). Fundamentos de administración financiera. México: Pearson Educación."]}
Published: 2023
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14. Challenges and Learning Curves in Adopting TaTME and Robotic Surgery for Rectal Cancer: A Cusum Analysis

Author: Pere Planellas, Lídia Cornejo, Anna Pigem, Núria Gómez-Romeu, David Julià-Bergkvist, Nuria Ortega, José Ignacio Rodríguez-Hermosa, and Ramon Farrés
Subjects: Robotics in medicina, Cancer Research, Oncology, Rectum -- Surgery, Rectum -- Cancer -- Treatment, Recte -- Cirurgia, Computer assisted surgery, Robòtica en medicina, Cirurgia assistida per ordinador, rectal cancer, taTME, robotic, learning curves, Recte -- Càncer -- Tractament
Abstract: New techniques are being developed to improve the results of laparoscopic surgery for rectal cancer. This paper analyzes the learning curves for transanal total mesorectal excision (taTME) and robot-assisted surgery in our colorectal surgery department. We analyzed retrospectively data from patients undergoing curative and elective surgery for rectal cancer ≤12 cm from the anal verge. We excluded extended surgeries. We used cumulative sum (CUSUM) curve analysis to identify inflection points. Between 2015 and 2021, 588 patients underwent surgery for rectal cancer at our center: 67 taTME and 79 robot-assisted surgeries. To overcome the operative time learning curve, 14 cases were needed for taTME and 53 for robot-assisted surgery. The morbidity rate started to decrease after the 17th case in taTME and after the 49th case in robot-assisted surgery, but it is much less abrupt in robot-assisted group. During the initial learning phase, the rate of anastomotic leakage was higher in taTME (35.7% vs. 5.7%). Two Urological lesions occurred in taTME but not in robot-assisted surgery. The conversion rate was higher in robot-assisted surgery (1.5% vs. 10.1%). Incorporating new techniques is complex and entails a transition period. In our experience, taTME involved a higher rate of serious complications than robot-assisted surgery during initial learning period but required a shorter learning curve.
Published: 2022
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15. Laparoscopic sigmoidectomy with complete mesocolic excision and extended lymphadenectomy: a video vignette

Author: Pere Planellas, Nuria Ortega, Eloy Maldonado, and Ramon Farrés
Subjects: Gastroenterology
Published: 2022

16. Prognostic significance of the microbiome–adipose tissue axis in rectal cancer: protocol of a prospective observational study

Author: Pere Planellas, Lídia Cornejo, Ramon Farrés, Anna Pigem, Ander Timoteo, Nuria Ortega, Gianluca Pellino, José-Ignacio Rodríguez-Hermosa, Eugeni López-Bonet, José Manuel Fernández-Real, Antoni Codina-Cazador, Institut Català de la Salut, [Planellas P, Farrés R] Colorectal Surgery Unit, Department of General and Digestive Surgery, University Hospital of Girona Dr. Josep Trueta, Girona, Spain. Girona Biomedical Research Institute (IDIBGI), Girona, Spain. Department of Medical Sciences, Faculty of Medicine, University of Girona, Girona, Spain. [Cornejo L] Girona Biomedical Research Institute (IDIBGI), Girona, Spain. [Pigem A, Timoteo A, Ortega N] Colorectal Surgery Unit, Department of General and Digestive Surgery, University Hospital of Girona Dr. Josep Trueta, Girona, Spain. Girona Biomedical Research Institute (IDIBGI), Girona, Spain. [Pellino G] Unitat de Cirurgia de Còlon i Recte, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Planellas, Pere, Cornejo, Lídia, Farrés, Ramon, Pigem, Anna, Timoteo, Ander, Ortega, Nuria, Pellino, Gianluca, Rodríguez-Hermosa, José-Ignacio, López-Bonet, Eugeni, Fernández-Real, José Manuel, and Codina-Cazador, Antoni
Subjects: Rectum -- Cancer, Prognosi, Rectal Neoplasms, Microbiota, Recte - Càncer - Prognosi, General Medicine, Prognosis, Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms::Rectal Neoplasms [DISEASES], neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales::neoplasias del recto [ENFERMEDADES], Prospective Studie, Teixit adipós, Observational Studies as Topic, Adipose Tissue, Humans, Intestins - Microbiologia, Prospective Studies, Recte -- Càncer, Human
Abstract: Colorectal cancer is the second-leading oncological cause of death worldwide1. Despite advances in treatment, there is still a risk of local and distant recurrence, which impacts on long-term outcomes This study was awarded a grant by the ‘Asociación Española de Coloproctolgía’ and ‘Col·legi Oficial de Metges de Girona—Joan Bruguera Grant’ in 2021.
Published: 2022

17. Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study (vol 46, pg 2021, 2022)

Author: Pata, Francesco, Di Martino, Marcello, Podda, Mauro, Di Saverio, Salomone, Ielpo, Benedetto, Pellino, ACIE Appy Study Collaborative Abba Julio, Gianluca., Abdullah, Alshamrani, Abdullah, Alturkistani, Abdulrahman, Alghamdi, Abdulrahman, Almalki, Adam, Orengia, Adnan, Kuvvetli, Adolfo, Pisanu, Adrian, Smith, Adriana Michelle Treviño Figueroa, Aeris Jane Nacion, Ahmad, Alhazmi, Ahmad, Bouhuwaish, Ahmad, Khalid, Ahmed, Alsufyani, Ainhoa Valle Rubio, Akshay, Bavikatte, Kumar, Akshay, Al-Radjid, Jamiri, Alberto de San Ildefonso Pereira, Alberto, Porcu, Alberto, Sartori, Aldo, Rocca, Aleksandar, Sretenovic, Anselmo, Alessandro, Alessandro De Luca, Alexandros, Charalabopoulos, Alexios, Tzivanakis, Alfonso, Bandin, Alfonso, Nájar, Alice, Frontali, Alsulaimani, Faisal, Amaia Martínez Roldan, Amal, Hamid, Ana, André, Ana, Minaya-Bravo, Andre, Das, Andrea, Bondurri, Andrea, Costanzi, Lucchi, Andrea, Andrei, Mihailescu, Police, Andrea, Andres Mendoza Zuchini, Angela, Romano, Iossa, Angelo, Antonella, Chessa, Antonella, Tromba, Antonio, Castaldi, Antonio, Brillantino, Antonio, Ferronetti, Giuliani, Antonio, Antonio Ramos-De la Medina, Antonio, Tarasconi, Arcangelo, Picciariello, Argyrios, Ioannidis, Ari, Leppäniemi, Arshad, Rashid, Ashrarur Rahman Mitul, Asif, Mehraj, Asim, Laharwal, Atif, Iqbal, Athanasios, Liarakos, Athanasios, Marinis, Beatriz de Andrés-Asenjo, Belén, Matías-García, DE SIMONE, Belinda, Ben, Creavin, Ben, Stubbs, Brian, Goh, Branislav, Jovanovic, Bruno, Sensi, Carlo, Gazia, Carlos, Cerdán, Carlos Javier Gómez Díaz, Carlos Petrola Chacón, Carlos, Yánez, Carmelo Lo Faro, Caroline, Reinke, Casandra, Dominguez, Charudutt, Paranjape, Charlotte, Thomas, Chia Chi Fung, DE LUCIA, Chiara, Chiu Hiu Fung Jennifer, Christian, Ovalle-Chao, Claudio, Guerci, Cleo, Kenington, Corina, Gica, Cristina, Folliero, Cristopher, Varela, Daniel, Popowich, Daniele, Delogu, Daniele, Zigiotto, Danilo, Vinci, Dario, D'Antonio, David Alessio Merlini, David, Merlini, David, Moro-Valdezate, Deborah, Keller, Diana Cristiana Nicolaescu, Diego, Sasia, Edgar, Rodas, Dimitrios, Linardoutsos, Domenico, Russello, Pedro Alfonso Nájar-Castañeda, Habil Gregor Stavrou, Edoardo, Rosso, Edoardo, Saladino, Edoardo, Ricciardi, Eduardo, Smith-Singares, Efstratia, Baili, Eleftheria, Douka, Guaitoli, Eleonora, Elisa, Francone, Elisa Maria Vaterlini, Elisa Sefora Pierobon, Emilio, Morales, Emilio Peña Ros, Enrico, Benzoni, Enrico, Erdas, Enrico, Pinotti, Enrique, Colás-Ruiz, Ernesto, Laterza, Esteban, Foianini, Eugenia, Cardamone, Eugenio, Licardie, Fabio, Marino, Fahad, Alsofyani, Fahad, Qahtani, Farhan, Khan, Fatlum, Maraska, Fatmir, Saliu, Fausto, Madrid, Fausto, Rosa, Federico, Luvisetto, Felipe, Alconchel, Felipe, Pareja-Ciuro, Fernanda, Neves, Ferdinando, Agresta, Fernando, Cordera, Fernando, Pardo, Fernando, Mendoza-Moreno, Fernando, Munoz-Flores, Francesca Maria Silvestri, Francesca Paola Tropeano, Francesca, Pecchini, Francesca, Serio, Francesco, Colombo, Francesco Di Marzo, Francesco, Ferrara, Francesco, Lancellotti, Francesco, Litta, Francesco, Martini, Francesco, Roscio, Francisco, Blanco-Antona, Francisco Javier Quezada Barcenas, Francisco, Schlottmann, Gabriel, Herrera-Almario, Gabrielle van Ramshorst, Gallo, Gaetano, Gaetano, Luglio, Georgios, Kampouroglou, Georgios, Papadopoulos, Gerardo, Arredondo, Giacomo, Calini, Giampaolo, Formisano, Galiffa, Giampaolo, Gian Marco Palini, Gianluca, Colucci, Gianluca, Pagano, Gianluca, Vanni, Gianmaria Casoni Pattacini, Gianpiero, Gravante, Giorgio, Lisi, Giovanni, Bellanova, Giovanni De Nobili, Giovanni Sammy Necchi, Sinibaldi, Giovanni, Giulia, Bacchiocchi, Giulia, Bagaglini, Maggi, Giulia, Giuliano, Izzo, Giulio, Argenio, Giuseppe, Brisinda, Giuseppe, Esposito, Giuseppe, Frazzetta, Giuseppe Massimiliano De Luca, Nigri, Giuseppe, Giuseppe, Sica, MARTIN DE MERCADO, Gonzalo, Gustavo Armand Ugon, Gustavo, Martinez-Mier, Gustavo Miguel Machain Vega, Gustavo, Nari, Herald, Nikaj, Ignacio, Neri, Igor Alberdi San Roman, Iliya, Fidoshev, Iñaki, Martínez, Ionut, Negoi, Irene, Ortega, Irune Vicente Rodríguez, Isabel, Cornejo, Ismael, Mora-Guzmán, Issam, Al-Najami, Ivan, Romic, Izaskun, Balciscueta, James, Olivier, Jan, Lammel-Lindemann, Jana, Dziakova, Javier, Salinas, Jelena Pejanovic Jovanovic, Jeryl Anne Silvia Reyes, Joanne, Salas, Jose Antonio Diaz-Elizondo, Jose Gustavo Parreira, Juan, Bellido, Juan, Salamea, Juan Carlos Martín Del Olmo, Juliana María Ordoñez, Sofi, Junaid, Justin, Davies, Kapil, Sahnan, Kebebe, Bekele, Kelvin, Voon, Leandro, Siragusa, Lorenzo, Petagna, Ferrario, Luca, Luca, Giordano, Luca, Nespoli, Luca, Pio, Lucia, Moletta, Luciano, Curella, Lucio, Taglietti, Luigi, Bonavina, Luigi, Conti, Luis Eduardo Pérez-Sánchez, Luis Felipe Cabrera Vargas, Luis, Sánchez-Guillén, Luis, Tallon-Aguilar, Mansoor, Khan, Marcello Giuseppe Spampinato, Marcelo, Viola, Marcelo Viola Malet, Angrisani, Marco, Marco, Calussi, Marco, Catarci, Marco, Giordano, Marco, Materazzo, Marco, Milone, Marco, Pellicciaro, Marco Vito Marino, María Daniela Moreno Villamizar, Lolli, MARIA GIULIA, Bellini, MARIA IRENE, Maria, Lemma, Maria Michela Chiarello, Mario, Montes-Manrique, Mario, Rodriguez-Lopez, Mario, Serradilla-Martín, Mark, Peter, Marta, Paniagua-García-Señoráns, Martin, Rutegård, Martin, Salö, Massimiliano, Silveri, Massimiliano, Veroux, Matteo, Nardi, Matteo, Rottoli, Matti, Tolonen, Mauricio Pedraza Ciro, Mauricio, Zuluaga, Maurizio, Iacobone, Mauro, Montuori, Mazin, Ali, Melody García Domínguez, Menna Maria Paola, Micaela, Piccoli, Michela, Campanelli, Michele De Rosa, Manigrasso, Michele, Maruccia, Michele, Michele, Torre, Michele, Zuolo, Miguel, Pera, Mihiri, Weerasekera, Mikel, Prieto, Min Myat Thway, Mohamed, Shaat, Mohammad, Azfar, Mostafa, Shalaby, Muhammad Asif Raza, Muhammad Umar Younis, Muhammed, Elhadi, Mujahid, Ali, Musab, Althomali, Nadiah Al Amri, Nagendra, Dudi-Venkata, Nahar, Alselaim, Neil, Smart, Nelson, Trelles, Nicolò, Falco, Petrucciani, Niccolo', Nicola, Antonacci, Nicola, Cillara, Nicolae, Gica, Nicolò, Pecorelli, Nicolò, Tamini, Nikolaos, Machairas, Nura, Feituri, Nuria Ortega Torrecilla, Octavio Avila Mercado, Ohood, Alaamer, Oktay, Irkorucu, Omar, Alsherif, Oreste Claudio Buonomo, Orestes, Valles-Guerra, Orestis, Ioannidis, Oscar Isaac Hernández Palmas, Oscar Sanz Guadarrama, Osman, Bozbiyik, Pablo, Rodrigues, Pamela, Milito, Paolo, Panaccio, Panagiotis, Dorovinis, Paola, Prieto, Paolo, Baroffio, Patrizia, Marsanic, Pawel, Ajawin, Peng Soon Koh, Pietro, Anoldo, Piotr, Major, Qasem, Alharthi, Rashid, Lui, Riccardo, Caruso, Richard, Brady, Rishi, Rattan, Rishi, Singhal, Roberta, Angelico, Roberta Maria Isernia, Roberta, Tutino, Roberto, Peltrini, Rodrigo, Tejos, Roosevelt, Fajardo, Rossella, Elia, Salvador, Morales-Conde, Sami, Benli, Sara, Fuentes, Sara Gortázar de Las Casas, Sara Ortiz de Guzmán Aragón, Sara, Vertaldi, Selmy, Awad, Sergio, Gentilli, Sergio Alberto Weckmann Lujan, Serkan, Tayar, Shabab, Althobaiti, DI GIOVANNI, Silvia, Soliman, Ghedan, Sonia, Pérez-Bertólez, Sonja, Chiappetta, Spiros, Delis, Stefano, Scaringi, Süleyman, Çetinkünar, Stylianos, Kykalos, Syed Muhammad Ali, Sylvia, Krivan, Tak Lit Derek Fung, Tarik, Delko, Tatiana Nicolás López, Tercio De Campos, Teresa Calderón Duque, Teresa, Perra, Theodore, Liakakos, Theodoros, Daskalakis, Tijmen, Koëter, Tiku, Zalla, Tomás Elosua González, Tommaso, Campagnaro, Toure Alpha Oumar, Ugo, Grossi, Valentina, Sosa, Valentina, Testa, Valentina, Tomajer, Valeria, Andriola, Valeria, Tonini, Valerio, Celentano, Voglino, Valerio, Venkateswara Rao Katta, Víctor Hugo García Orozco, Victor, Turrado-Rodriguez, Victor, Visag-Castillo, Victoria, Graham, Viktor, Rachkov, Vincenzo, Papagni, Vincenzo, Vigorita, Virginia Jiménez Carneros, Bellato, Vittoria, Wolf, Bechstein, Yuksel, Altinel, and Zutoia, Balciscueta
Subjects: appendicitis, COVID19
Published: 2022

18. Persistence of SARS-CoV-2 total immunoglobulins in a series of convalescent plasma and blood donors

Author: M. Carmen Martin, Ana Jimenez, Nuria Ortega, Alba Parrado, Isabel Page, M. Isabel Gonzalez, and Lydia Blanco-Peris
Subjects: Adult, Aged, 80 and over, Male, Multidisciplinary, SARS-CoV-2, Immunization, Passive, COVID-19, Blood Donors, Adaptive Immunity, Middle Aged, Antibodies, Viral, Antibodies, Neutralizing, Plasma, Immunoglobulin G, Humans, Female, COVID-19 Serotherapy, Aged
Abstract: Background The vast majority of COVID-19 cases both symptomatic and asymptomatic develop immunity after COVID-19 contagion. Whether lasting differences exist between infection and vaccination boosted immunity is yet to be known. The aim of this study was to determine how long total anti-SARS-CoV2 antibodies due to past infection persist in peripheral blood and whether sex, age or haematological features can influence their lasting. Material and methods A series of 2421 donations either of SARS-CoV-2 convalescent plasma or whole blood from 1107 repeat donors from January 2020 to March 2021 was analysed. An automated chemiluminescence immunoassay for total antibodies recognizing the nucleocapsid protein of SARS-CoV-2 in human serum and plasma was performed. Sex, age, blood group, blood cell counts and percentages and immunoglobulin concentrations were extracted from electronic recordings. Blood donation is allowed after a minimum of one-month post symptom’s relapse. Donors were 69.7% males and their average age was 46. The 250 donors who had later donations after a positive one underwent further analysis. Both qualitative (positivity) and quantitative (rise or decline of optical density regarding consecutive donations) outcomes were evaluated. Results and discussion In 97.6% of donors with follow-up, anti-SARS-CoV-2 protein N total antibodies remained positive at the end of a follow-up period of 12.4 weeks median time (1–46, SD = 9.65) after the first positive determination. The blood group was not related to antibody waning. Lower lymphocyte counts and higher neutrophils would help predict future waning or decay of antibodies. Most recovered donors maintain their total anti-SARS-CoV-2 N protein antibodies for at least 16 weeks (at least one month must have been awaited from infection resolution to blood donation). The 10 individuals that could be followed up longer than 40 weeks (approximately 44 weeks after symptom’s relapse) were all still positive.
Published: 2021

19. Long term positivity of SARS-CoV-2 total immunoglobulins in convalescent plasma and blood donors

Author: Ana Jiménez, M Isabel Gonzalez, M Carmen Martin, Alba Parrado, Isabel Page, Lydia Blanco-Peris, and Nuria Ortega
Subjects: biology, medicine.diagnostic_test, business.industry, Lymphocyte, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Herd immunity, Vaccination, medicine.anatomical_structure, Immunity, Ageing, Immunoassay, Immunology, medicine, biology.protein, Antibody, business
Abstract: BackgroundOne of the most questioned issues about SARS-CoV2 immunity is how long does it last. Whether lasting differences exist between infection and vaccination boosted immunity is yet to be known. The answer to this question will determine key issues such as the reliability of individual and herd immunity or the need of sanitary restrictions or periodical revaccination. The aim of this study was to determine how long total anti SARS-CoV2 antibodies due to past infection persist in peripheral blood and whether sex, age or haematological features can influence their lasting.Material and MethodsA total of 2432 donations SARS-CoV-2 from 662 repeat donors from April 2020 to February 2021 were analysed. Donors were 69.7% males and their average age was 46. An automated chemilumiscence immunoassay for total antibodies recognizing N protein of SARS-CoV-2 in human serum and plasma was performed.Results and discussionIn 97.6% donors with follow-up, anti SARS-CoV-2 protein N total antibodies remained positive up to 46 weeks after first positive determination. Blood group was not related to antibody waning. Lower lymphocyte counts and higher neutrophils and as well higher seric IgA would help predict future negativization of antibodies. The vast majority of donors keep their total immunoglobulins anti SARS-CoV-2 positive for longer than 10 months. Ageing might have a protective effect against antibody waning but, given the small number of cases that become negative, more studies, or larger cohorts would be needed to confirm these facts.
Published: 2021

20. SARS-CoV-2 seroprevalence and gender-related haematological features in asymptomatic blood donors

Author: Lydia Blanco-Peris, Isabel Page, Ana Jiménez, Nuria Holgado, María Honrubia Pérez, Nuria Ortega, M Isabel Gonzalez, Alba Parrado, and M Carmen Martin
Subjects: education.field_of_study, medicine.medical_specialty, biology, business.industry, Lymphocyte, Population, Psychological intervention, Neutropenia, medicine.disease, Asymptomatic, medicine.anatomical_structure, Internal medicine, Pandemic, medicine, biology.protein, Seroprevalence, medicine.symptom, Antibody, education, business
Abstract: Background and objectivesCOVID-19 can either cause death or go unnoticed but antibodies will remain protecting us of SARS-CoV-2 reinfection for an uncertain time and to an uncertain extent. Our aim was to describe seroprevalence evolution from summer 2019 to autumn 2020 in Spain and to describe its relationship with age, blood group and haematological parameters.Materials and methodsSera and plasma from historical donation archives excluding convalescent were randomized and a total of 12,313 donations tested by a Chemiluminiscent analysis for anti SARS-CoV-2 N protein total immunoglobulins. Blood donors were 60.9% males, average age 46+/-13. Sex, age, blood group, blood cell counts and percentages and immunoglobulin concentrations were extracted from electronic recordings.ResultsA seroprevalence of 6.7% in blood donors was found by the end of the first wave. No differences by sex, age or blood group were found regarding antibodies. Leukocyte count (p=0.026), haematocrit (pConclusionsSeroprevalence due to asymptomatic cases would resemble that of global population. Sex and age would not affect COVID-19 susceptibility but its severity. Gender differences related to COVID-19 in leukocytes, haemoglobin and haematocrit would be present in asymptomatic individuals. Further studies are needed to confirm these gender differences as they can help better understand the immune response to COVID-19, its pathogenesis and prognosis.
Published: 2021

21. Implant of Self-Expandable Artificial Anal Sphincter in Patients With Fecal Incontinence Improves External Anal Sphincter Contractility

Author: Francesco, Litta, Angelo A, Marra, Nuria, Ortega Torrecilla, Raffaele, Orefice, Angelo, Parello, Veronica, De Simone, Paola, Campennì, Marta, Goglia, and Carlo, Ratto
Subjects: Male, Manometry, Anal Canal, Prostheses and Implants, Middle Aged, Prosthesis Design, Severity of Illness Index, Endosonography, Prosthesis Implantation, Treatment Outcome, Muscle Tonus, Humans, Female, Prospective Studies, Safety, Defecation, Fecal Incontinence, Aged, Follow-Up Studies
Abstract: External anal sphincter contractility significantly contributes to control the passage of stool. An artificial anal sphincter placed into the intersphincteric space is a safe and effective procedure to treat fecal incontinence, even if its mechanism of action has not been fully elucidated.The aim of this study was to evaluate external anal sphincter contractility changes after a self-expandable hyexpan prostheses was implanted into the intersphincteric space of the anal canal and clinical outcomes compared.This was a prospective clinical study.The study was conducted at a university teaching hospital.Consecutive patients affected by fecal incontinence for at least 6 months after failure of conservative treatment were included.All of the patients underwent 10-prostheses implantation and were examined preoperatively and postoperatively by endoanal ultrasound and anorectal manometry.Fecal incontinence symptoms were assessed by severity scores. The external anal sphincter muscle tension was calculated using a specific equation.Thirty-nine patients (34 women; median age = 68 y) were included in the study; no morbidity was registered. After a median follow-up period of 14 months, both the median maximum voluntary squeeze pressure and the median inner radius of the external anal sphincter significantly increased. A statistically significant increase of external anal sphincter muscle tension was detected. A decrease of any fecal incontinence symptom and an improvement in severity scores were observed at the last follow-up examination. The external anal sphincter contractility was significantly higher in patients reducing incontinence episodes to solid stool by50% and improving their ability to defer defecation for15 minutes.This was a single-center experience with a relatively small and heterogeneous sample size, patients with a potentially more severe disease because our institution is a referral center, and an absence of quality-of-life evaluation.Artificial anal sphincter implantation improved the external anal sphincter muscle tension; there was a positive correlation between its increase and the clinical outcome. See Video Abstract at http://links.lww.com/DCR/B468.ANTECEDENTES:La contractilidad del esfínter anal externo contribuye significativamente al control del paso de las heces. Un esfínter anal artificial colocado en el espacio interesfinteriano es un procedimiento seguro y eficaz para tratar la incontinencia fecal, incluso si su mecanismo de acción no se ha definido por completo.OBJETIVO:El objetivo de este estudio fue evaluar los cambios en la contractilidad del esfínter anal externo después de la implantación de una prótesis de hyexpan autoexpandible en el espacio interesfinteriano del canal anal y comparar los resultados clínicos.DISEÑO:Estudio clínico prospectivo.ENTORNO CLINICO:El estudio se realizó en un hospital universitario.PACIENTES:Pacientes consecutivos afectados por incontinencia fecal durante al menos 6 meses, tras fracaso de tratamiento conservador.INTERVENCIONES:Todos los pacientes fueron sometidos a la implantación de 10 prótesis, y fueron examinados pre y postoperatoriamente mediante ecografía endoanal y manometría anorrectal.PRINCIPALES MEDIDAS DE VALORACION:Los síntomas de incontinencia fecal se evaluaron mediante puntuaciones de gravedad. La tensión del músculo del esfínter anal externo se calculó mediante una formula específica.RESULTADOS:Treinta y nueve pacientes (34 mujeres; mediana de edad 68 años) fueron incluidos en el estudio; no se registró morbilidad. Después de un período de seguimiento medio de 14 meses, tanto la presión de compresión voluntaria máxima media como el radio interior medio del esfínter anal externo aumentaron significativamente. Se detectó un aumento estadísticamente significativo de la tensión del músculo del esfínter anal externo. En el último examen de seguimiento se observó una disminución de cualquier síntoma de incontinencia fecal y una mejora en las puntuaciones de gravedad. La contractilidad del esfínter anal externo fue significativamente mayor en los pacientes que redujeron los episodios de incontinencia a heces sólidas en más del 50% y mejoraron la capacidad para diferir la defecación durante más de 15 minutos.LIMITACIONES:Experiencia de un solo centro; tamaño de muestra relativamente pequeño y heterogéneo; pacientes con una enfermedad potencialmente más grave porque nuestra institución es un centro de referencia; ausencia de evaluación de la calidad de vida.CONCLUSIONES:La implantación del esfínter anal artificial mejoró la tensión muscular del esfínter anal externo; hubo una correlación positiva entre su aumento y el resultado clínico. Consulte Video Resumen en http://links.lww.com/DCR/B468.
Published: 2021

22. Implant of Self-Expandable Artificial Anal Sphincter in Fecal Incontinent Patients Improves External Anal Sphincter Contractility

Author: Angelo Parello, Paola Campennì, Marta Goglia, Raffaele Orefice, Francesco Litta, Nuria Ortega Torrecilla, Carlo Ratto, Angelo Alessandro Marra, and Veronica De Simone
Subjects: Gynecology, medicine.medical_specialty, business.industry, External anal sphincter, Settore MED/18 - CHIRURGIA GENERALE, Anorectal manometry, Gastroenterology, General Medicine, Anal canal, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, N/A, 030220 oncology & carcinogenesis, Muscle tension, Endoanal ultrasound, medicine, Defecation, Fecal incontinence, 030211 gastroenterology & hepatology, Implant, medicine.symptom, business
Abstract: Background External anal sphincter contractility significantly contributes to control the passage of stool. An artificial anal sphincter placed into the intersphincteric space is a safe and effective procedure to treat fecal incontinence, even if its mechanism of action has not been fully elucidated. Objective The aim of this study was to evaluate external anal sphincter contractility changes after a self-expandable hyexpan prostheses was implanted into the intersphincteric space of the anal canal and clinical outcomes compared. Design This was a prospective clinical study. Settings The study was conducted at a university teaching hospital. Patients Consecutive patients affected by fecal incontinence for at least 6 months after failure of conservative treatment were included. Interventions All of the patients underwent 10-prostheses implantation and were examined preoperatively and postoperatively by endoanal ultrasound and anorectal manometry. Main outcome measures Fecal incontinence symptoms were assessed by severity scores. The external anal sphincter muscle tension was calculated using a specific equation. Results Thirty-nine patients (34 women; median age = 68 y) were included in the study; no morbidity was registered. After a median follow-up period of 14 months, both the median maximum voluntary squeeze pressure and the median inner radius of the external anal sphincter significantly increased. A statistically significant increase of external anal sphincter muscle tension was detected. A decrease of any fecal incontinence symptom and an improvement in severity scores were observed at the last follow-up examination. The external anal sphincter contractility was significantly higher in patients reducing incontinence episodes to solid stool by >50% and improving their ability to defer defecation for >15 minutes. Limitations This was a single-center experience with a relatively small and heterogeneous sample size, patients with a potentially more severe disease because our institution is a referral center, and an absence of quality-of-life evaluation. Conclusions Artificial anal sphincter implantation improved the external anal sphincter muscle tension; there was a positive correlation between its increase and the clinical outcome. See Video Abstract at http://links.lww.com/DCR/B468. Implante de esfnter anal artificial autoexpandible en pacientes con incontinencia fecal mejora la contractilidad del esfnter anal externo ANTECEDENTES:La contractilidad del esfinter anal externo contribuye significativamente al control del paso de las heces. Un esfinter anal artificial colocado en el espacio interesfinteriano es un procedimiento seguro y eficaz para tratar la incontinencia fecal, incluso si su mecanismo de accion no se ha definido por completo.OBJETIVO:El objetivo de este estudio fue evaluar los cambios en la contractilidad del esfinter anal externo despues de la implantacion de una protesis de hyexpan autoexpandible en el espacio interesfinteriano del canal anal y comparar los resultados clinicos.DISENO:Estudio clinico prospectivo.ENTORNO CLINICO:El estudio se realizo en un hospital universitario.PACIENTES:Pacientes consecutivos afectados por incontinencia fecal durante al menos 6 meses, tras fracaso de tratamiento conservador.INTERVENCIONES:Todos los pacientes fueron sometidos a la implantacion de 10 protesis, y fueron examinados pre y postoperatoriamente mediante ecografia endoanal y manometria anorrectal.PRINCIPALES MEDIDAS DE VALORACION:Los sintomas de incontinencia fecal se evaluaron mediante puntuaciones de gravedad. La tension del musculo del esfinter anal externo se calculo mediante una formula especifica.RESULTADOS:Treinta y nueve pacientes (34 mujeres; mediana de edad 68 anos) fueron incluidos en el estudio; no se registro morbilidad. Despues de un periodo de seguimiento medio de 14 meses, tanto la presion de compresion voluntaria maxima media como el radio interior medio del esfinter anal externo aumentaron significativamente. Se detecto un aumento estadisticamente significativo de la tension del musculo del esfinter anal externo. En el ultimo examen de seguimiento se observo una disminucion de cualquier sintoma de incontinencia fecal y una mejora en las puntuaciones de gravedad. La contractilidad del esfinter anal externo fue significativamente mayor en los pacientes que redujeron los episodios de incontinencia a heces solidas en mas del 50% y mejoraron la capacidad para diferir la defecacion durante mas de 15 minutos.LIMITACIONES:Experiencia de un solo centro; tamano de muestra relativamente pequeno y heterogeneo; pacientes con una enfermedad potencialmente mas grave porque nuestra institucion es un centro de referencia; ausencia de evaluacion de la calidad de vida.CONCLUSIONES:La implantacion del esfinter anal artificial mejoro la tension muscular del esfinter anal externo; hubo una correlacion positiva entre su aumento y el resultado clinico. Consulte Video Resumen en http://links.lww.com/DCR/B468.
Published: 2021

23. Global attitudes in the management of acute appendicitis during COVID-19 pandemic: ACIE Appy Study

Author: Benedetto, Ielpo, Mauro, Podda, Gianluca, Pellino, Pata, Francesco, Gianpiero, Gravante, Salomone Di Saverio, Gallo, Gaetano, Rashid, Lui, Adam, Orengia, Aditya, Chowdary, Aditya, Kulkarni, Adnan, Kuvvetli, Adolfo, Navarro, Adolfo, Pisanu, Adrian, Smith, Adriana Cavero Ibiricu, Aeris Jane, D Nacion, Ahmad, Alsaleh, Ahmad, Alhazmi, Ahmad, Elmabri, Ajaz, Wani, Ahmet, Rencuzogullari, Aingeru Sarriugarte Lasarte, Ainhoa Valle Rubio, Akshay, Bavikatte, Akshay, Kumar, Al-Radjid, Jamiri, Alain Michel Alvarado Padilla, Alban, Cacurri, Alberto de San Ildefonso, Alberto, Porcu, Alberto, Sartori, Aldo, Rocca, Alejandro Paz Yáñez, Alejandro, Becaria, Alejandro, Solís-Peña, Aleksandar, Sretenović, Alex, Urbistondo, Alfonso, Bandin, Alfonso, Najar, Alessandro De Luca, Alex, Boddy, Alexandros, Charalabopoulos, Alexios, Tzivanakis, Alfonso, Amendola, Alfredo Ramirez-Gutierrez de Velasco, Ali Cihat Yildirim, Alice, Frontali, Alpha Oumar Toure, Alvaro, García-Granero, Amaia Martínez Roldan, Amaia Sanz Larrainzar, Amila Sanjiva Ratnayake, Ana María Gonzalez-Ganso, Ana, M Minaya-Bravo, Andre, Das, Andrea, Bondurri, Andrea, Costanzi, Andrea, Lucchi, Andrea, Mazzari, Andrea, Musig, Andrea, Peloso, Andrea, Piano, Andrea, Police, Andrei, Mihailescu, Andrés, Pouy, Angela, Romano, Iossa, Angelo, Anna Carmen Leonetti, Anna, Guariniello, Anna, Isaac, Anna Pia Delli Bovi, Antonella, Chessa, Antonella, Tromba, Antonio Álvarez Martínez, Antonio, Brillantino, Antonio, Caira, Antonio, Castaldi, Antonio, Ferronetti, Antonio, Giuliani, Antonio, Prestera, Antonio Ramos-De la Medina, Antonio, Tarasconi, Antonino, Tornambè, Arcangelo, Picciariello, Argyrios, Ioannidis, Ari, Leppäniemi, Arshad, Khan, Arshad, Rashid, Arteaga Luis Eduardo Pérez-Sánchez, Ashok, Mittal, Ashrarur Rahman Mitul, Asif, Mehraj, Asim, Laharwal, Asnel, Dorismé, Athanasios, Marinis, Atif, Iqbal, Augusto, Moncada, Bartolomeo, Braccio, Basim, Alkhafaji, Beatriz de Andrés Asenjo, Beatriz, Martin-Perez, Belinda Sánchez Pérez, Ben, Creavin, Benedetto, Calì, Beniamino, Pascotto, Benjamin, Stubbs, Benjamin Zavala Retes, Branislav, Jovanovic, Brian Kp Goh, Bruno, Sensi, Carlo, Biddau, Carlo, Gazia, Carlo, Vallicelli, Carlos Alberto Fagundes, Carlos Cerdán Santacruz, Carlos, Chirico, Carlos Javier Gómez, Carlos, Petrola, Carlos Sánchez Rodriguez, Carlos Yánez Benítez, Carmelisa, Dammaro, Carmelo Lo Faro, Caroline, Reinke, Casandra Dominguez Paez, Catalina, Oliva, Charudutt, Paranjape, Charlotte, Thomas, Chi Fung Chia, Chi Kwan Kong, Chiara De Lucia, Christian Ovalle Chao, Claudio, Arcudi, Claudio, Guerci, Clement, Chia, Cristiano, Parise, Cristina, Folliero, Cristopher, Varela, Dalya, M Ferguson, Daniel, Camacho, Daniel, Popowich, Daniel Souza Lima, Daniela, Rega, Daniele, Delogu, Daniele, Zigiotto, Danilo, Vinci, Dario, D'Antonio, Dario, Parini, David Alessio Merlini, David DE Zimmerman, David, Moro-Valdezate, Davide, Pertile, Deborah Maria Giusti, Deborah, S Keller, Delko, Tarik, Denis, Kalivaçi, Dennis, Mazingi, Diana Gabriela Maldonado-Pintado, Diego, Sasia, Dimitrios, Linardoutsos, Dixon, Osilli, Domenico, Murrone, Domenico, Russello, Edgar, Rodas, Edisson Alberto Acuña Roa, Edoardo, Ricciardi, Edoardo, Rosso, Edoardo, Saladino, Eduardo, Flores-Villalba, Eduardo Ruiz Ajs, Eduardo, Smith-Singares, Efstratia, Baili, Efstratios, Kouroumpas, Eirini, Bourmpouteli, Eleftheria, Douka, Elena, Martin-Perez, Eleonora, Guaitoli, Elgun, Samadov, Elisa, Francone, Elisa, Vaterlini, Emilio, Morales, Emilio, Peña, Enhao, Zhao, Eneko Del Pozo Andres, Enrico, Benzoni, Enrico, Erdas, Enrico, Pinotti, Enrique, Colás-Ruiz, Erman, Aytac, Ernesto, Laterza, Ervis, Agastra, Esteban, Foianini, Esteban, Moscoso, Estefania, Laviano, Ester, Marra, Eugenia, Cardamone, Eugenio, Licardie, Eustratia, Mpaili, Eva, Pinna, Evaristo, Varo, Fabian Martín Navarro, Fabio, Marino, Fabio, Medas, Fabio, Romano, Fatlum, Maraska, Fatmir, Saliu, Fausto, Madrid, Fausto, Rosa, Federica, Mastella, Federico, Gheza, Federico, Luvisetto, Felipe, Alconchel, Felipe Monge Vieira, Felipe, Pareja, Ferdinando, Agresta, Fernanda, Luna, Fernando, Bonilla, Fernando, Cordera, Fernando, Burdió, Fernando, Mendoza-Moreno, Fernando Muñoz Flores, Fernando Pardo Aranda, Fiona, Taylor, Flavia, L Ramos, Flavio, Fernandes, Francesca Paola Tropeano, Francesco, Balestra, Francesco, Bianco, Francesco, Ceci, Francesco, Colombo, Francesco Di Marzo, Francesco, Ferrara, Francesco, Lancellotti, Francesco, Lazzarin, Francesco, Litta, Francesco, Martini, Francesco, Pizza, Francesco, Roscio, Francesco, Virdis, Francisco Blanco Antona, Francisco Cervantes Ramírez, Francisco Miguel Fernandez, Francisco Oliver Llinares, Francisco, Quezada, Francisco, Schlottmann, Gabriel, Herrera-Almario, Gabriel, Massaferro, Gabriele, Bislenghi, Gabrielle van Ramshorst, Gaetano, Gallo, Gaetano, Luglio, Georgios, Bointas, Georgios, Kampouroglou, Georgios, Papadopoulos, Gerardo Arredondo Manrique, Giacomo, Calini, Giacomo, Nastri, Giampaolo, Formisano, Giampaolo, Galiffa, Gian Marco Palini, Gianluca, Colucci, Gianluca, Pagano, Gianluca, Vanni, Gianmaria Casoni Pattacini, Gilda De Paola, Giorgio, Lisi, Giovanna, Partida, Giovanni, Bellanova, Giovanni De Nobili, Giovanni Sammy Necchi, Giovanni, Sinibaldi, Giovanni, Tebala, Giulia, Bagaglini, Giuliano, Izzo, Giulio, Argenio, Giuseppe, Brisinda, Giuseppe, Candilio, Giuseppe Di Grezia, Giuseppe, Esposito, Giuseppe, Faillace, Giuseppe, Frazzetta, Giuseppe La Gumina, Giuseppe, Nigri, Giuseppe, Romeo, Gloria Chocarro Amatriaín, Gloria, Ortega, Gonzalo, Martin-Martin, Gregor, A Stavrou, Gunadi, Gustavo Armand Ugon, Gustavo, Machain, Gustavo, Marcucci, Gustavo, Martínez-Mier, Gustavo Miguel Machain, Gustavo, Nari, Haydée, Calvo, Hamada, Fathy, Hamilto, Hazem, Ahmed, Hazem, Faraj, Hector, Nava, Hector Ordas Macias, Herald, Nikaj, Heriberto, Solano, Huma Ahmed Khan, Humberto Sánchez Alarcón, Husam, Ebied, Iacopo, Giani, Ibabe Villalabeitia Ateca, Ignacio, Neri, Igor Alberdi San Roman, Iliya, Fidoshev, Iñaki Martinez Rodriguez, Ionut, Negoi, Irene, Ortega, Irina, Bernescu, Iris Shari Russo, Irune Vincente Rodríguez, Irving, Palomares, Isaac, Baltazar, Isabel Jaén Torrejimeno, Isabel María Cornejo Jurado, Isabella, Reccia, Ishtiyaq, Hussain, Ismael Brito Toledo, Ismael, Mora-Guzmán, Iulia, Dogaru, Ivan, Romic, Izaskun, Balciscueta, J Cleo Kenington, Jackison, Sagolsem, Jae, Y Jang, James, Olivier, Jan, Lammel-Lindemann, Jana, Dziakova, Javier Ismael Roldán Villavicencio, Javier, Salinas, Jelena, Pejanovic, Jose Gustavo Parreira, Jovanovic, Jeny Rincón Pérez, Jeryl, Asreyes, Jesus Antonio Medina Luque, Joanna, Mak, Joanne Salas Rodriguez, Johnn Henry Herrera Kok, Jon, Krook, Jose Antonio Diaz-Elizondo, Jose, Castell, José Eduardo García-Flores, José María Jover Navalón, Jose Mauro Silva Rodrigues, José, Pereira, José Tomas Castell Gómez, Juan Bellido Luque, Juan Carlos Martín Del Olmo, Juan Carlos Salamea, Juan Francisco Coronel Olivier, Juan Luis Blas Laina, Juliana Maria Ordoñez, Julieta, Gutierrez, Julio, Abba, Junaid Ahmad Sofi, Kashaf, Sherafgan, Kapil, Sahnan, Katsuhiko, Yanaga, Kevin, Beatson, Laharwal, Asim, Laura, Alvarez, Leandro, Siragusa, Lee, Farber, Lester, Ong, Liarakos, Athanasios, Lorena, García-Bruña, Luca De Martino, Luca, Ferrario, Luca, Giordano, Luca, Gordini, Luca, Pio, Luca, Ponchietti, Lucia, Moletta, Luciano, Curella, Luciano, Poggi, Lucio, Taglietti, Luigi, Bonavina, Luigi, Conti, Luigi, Goffredi, Luis Angel Garcia Ruiz, Luis, Barrionuevo, Luis Enrique Fregoso, Luis, F Cabrera, Luis, G Rodriguez, Luis, Grande, Luis Gregorio Osoria, Luis Javier Kantun Gonzalez, Luis, Sánchez-Guillén, Luis, Tallon-Aguilar, Luis, Tresierra, Luisa, Giavarini, Mahmoud, Hasabelnabi, Maja, Odovic, Mamoru, Uemura, Mansoor, Khan, Manuel, Artiles-Armas, Mara, David, Marcello Di Martino, Marcello Giuseppe Spampinato, Marcelo A, F Ribeiro, Marcelo, Viola, Marco, Angrisani, Marco, Calussi, Marco, Cannistrà, Marco, Catarci, Marco, Cereda, Marco, Conte, Marco, Giordano, Marco, Pellicciaro, Marco Vito Marino, Maria, E Vaterlini, María, F Jiménez, María Giulia Lolli, Bellini, MARIA IRENE, Maria, Lemma, Maria Michela Chiarello, Maria, Nicola, Mario, Arrigo, Mario Caneda Mejia, Mario Montes Manrique, Mario, Rodriguez-Lopez, Mario, Serradilla-Martín, Mario Zambrano Lara, Marisa, Martínez, Mark, Bagnall, Mark, Peter, Marta Cañón Lara, Marta Jimenez Gomez, Marta, Paniagua-Garcia-Señorans, Marta Perez Gonzalez, Martin, Rutegård, Martin, Salö, Marzia, Franceschilli, Massimiliano, Silveri, Massimiliano, Veroux, Massimo, Pezzulo, Matteo, Nardi, Matteo, Rottoli, Matti, Tolonen, Mauricio Pedraza Ciro, Mauricio, Zuluagua, Maurizio, Cannavò, Maurizio, Cervellera, Maurizio, Iacobone, Mauro, Montuori, Melody García Domínguez, Meltem, Bingol-Kologlu, Mian, Tahir, Michael, Lim, Michael Sj Wilson, Michael, Wilson, Michela, Campanelli, Michele, Bisaccia, Michele De Rosa, Michele, Maruccia, Michele, Paterno, Michele, Pisano, Michele, Torre, Michele, Treviño, Michele, Zuolo, Miguel, A Hernandez Bartolome, Miguel, Farina, Miguel, Pera, Miguel Prieto Calvo, Milagros, Sotelo, Min Myat Thway, Mohamed, Hassan, Mohamed Salah Eldin Hassan, Mohammad, Azfar, Mohammad, Bouhuwaish, Mohammad, Taha, Mohammad, Zaieem, Mohammed, Korkoman, Montserrat, Guraieb, Mostafa, Shalaby, Muhammad Asif Raza, Muhammad Umar Younis, Muhammed, Elhadi, Mujahid Zulfiqar Ali, Nadeem, Quazi, Nagendra, N Dudi-Venkata, Nahar, Alselaim, Natasha, Loria, Nathalie Villan Ramírez, Nay Win Than, Neil, Smart, Nelson, Trelles, Nicanor, Pinto, Niccolò, Allievi, Niccolo, Petrucciani, Nicola, Antonacci, Nicola, Cillara, Nicolae, Gica, Nicolaescu Diana Cristiana, Nicolás, Nicolás, Nicolò, Falco, Nicolò, Pecorelli, Nicolò, Tamini, Nikolaos Andreas Dallas, Nikolaos, Machairas, Noelia, Brito, Nura Ahmed Fieturi, Nuria, Ortega, Octavio, Avilamercado, Oktay, Irkorucu, Omar, Alsherif, Orestes, Valles, Orestis, Ioannidis, Oscar Hernández Palmas, Oscar Isaac Hernandez Palmas, Oscar Sanz Guadarrama, Osman, Bozbiyik, Pablo, Omelanczuk, Pablo, Ottolino, Pablo, Rodrigues, Pablo, Ruiz, Paola, Campenni, Paola, Chiarade, Paola Prieto Olivares, Paolo, Baroffio, Pascal, Wintringer, Pasquale Di Fronzo, Pasquale, Talento, Pasqualino, Favoriti, Patricia, Sendino, Patrizia, Marsanic, Patricia, Mifsut, Paúl, Andrade, Pawel, Ajawin, Valentina, Ferri, Giuseppe Massimiliano de Luca, Sara, Ingallinella, Eva, Pueyo, Francesco, Palmieri, Jesus, Silva, Ken Min Chin, Nicholas, Syn, Brian K, P Goh, Ye Xin Koh, Valeria, Tonini, Ana, Gonzales-Ganso, Vicente, Simó, Maria Victoria Diago, Pedro, Abadía-Barnó, Pedro Alfonso Najar Castañeda, Pedro Omar Sillas Arevalos, Pedro Palazón Bellver, Peng Soon Koh, Petry, Souza, Piotr, Major, Rajandeep Singh Bali, Rakesh Mohan Khattar, Renato Bessa Melo, Reza, Ebrahiminia, Ricardo, Azar, Ricardo López Murga, Riccardo, Caruso, Riccardo, Pirolo, Richard, Brady, Richard Justin Davies, Rishi, Dholakia, Rishi, Rattan, Rishi, Singhal, Robert, Lim, Roberta, Angelico, Roberta Maria Isernia, Roberta, Tutino, Roberto, Faccincani, Roberto, Peltrini, Rocío, Carrera-Ceron, Rodrigo, Tejos, Rohit, Kashyap, Roosevelt, Fajardo, Rosa, Lozito, Royer Madariaga Pareja, Sabrina, Garbarino, Salvador, Morales-Conde, Sami, Benli, Sami, Mansour, Samir, Flores, Samuel Limon Suarez, Santiago Lopez Ben, Sara, Fuentes, Sara, Napetti, Sara Ortiz de Guzmán, Selmy, Awad, Sergio, A Weckmann Luján, Sergio, Gentilli, Sergio, Grimaldi, Sergio Olivares Pizarro, Serkan, Tayar, Shakeeb, Nabi, Shannon, M Chan, Sheikh, Junaid, Sidney, Rojas, Silvana, Monetti, Silvia, García, Silvia, Salvans, Silvia, Tenconi, Simon, Shaw, Simone, Santoni, Sofia Andrea Parra, Sofía, Cárdenas, Sonia, Pérez-Bertólez, Sonja, Chiappetta, Sophie, Dessureault, Spiros, Delis, Stefano Amore Bonapasta, Stefano, Rausei, Stefano, Scaringi, Sundeep, Keswani, Syed Muhammad Ali, Süleyman, Cetinkunar, Tak Lit Derek Fung, Tariq, Rawashdeh, Tatiana Nicolás López, Tercio De Campos, Teresa Calderon Duque, Teresa, Perra, Theodore, Liakakos, Theodoros, Daskalakis, Theodoros, Liakakos, Thomas, Barnes, Tijmen, Koëter, Tiku, Zalla, Tomás, E González, Tomás, Elosua, Tommaso, Campagnaro, Tommy, Brown, Topi, Luoto, Touré Alpha Oumar, Ugo, Giustizieri, Ugo, Grossi, Umberto, Bracale, Uriel, Rivas, Valentina, Sosa, Valentina, Testa, Valeria, Andriola, Valerio, Balassone, Valerio, Celentano, Valerio, Progno, Varun, Raju, Vanessa, Carroni, Venera, Cavallaro, Venkateswara Rao Katta, Veronica De Simone, Vicent Primo Romaguera, Victor Hugo García Orozco, Victor, Luraschi, Victor, Rachkov, Victor, Turrado-L, Victor, Visag-Castillo, Victoria, Dowling, Victoria, Graham, Vincenzo, Papagni, Vincenzo, Vigorita, Vinicius Cordeiro Fonseca, Virginia Jimenez Carneros, Vittoria, Bellato, Walyson, Gonçalves, William, F Powers, William, Grigg, Wolf, O Bechstein, Yu Bing Lim, Yuksel, Altinel, Zoran, Golubović, Zutoia, Balciscueta, Ielpo B., Podda M., Pellino G., Pata F., Caruso R., Gravante G., Di Saverio S., Gallo G., Lui R., Orengia A., Chowdary A., Kulkarni A., Kuvvetli A., Navarro A., Pisanu A., Smith A., Ibiricu A.C., Nacion A.J.D., Alsaleh A., Alhazmi A., Elmabri A., Wani A., Rencuzogullari A., Lasarte A.S., Rubio A.V., Bavikatte A., Kumar A., Jamiri A.-R., Padilla A.M.A., Cacurri A., de San Ildefonso A., Porcu A., Sartori A., Rocca A., Yanez A.P., Becaria A., Solis-Pena A., Sretenovic A., Urbistondo A., Bandin A., Najar A., De Luca A., Boddy A., Charalabopoulos A., Tzivanakis A., Amendola A., de Velasco A.R.-G., Yildirim A.C., Frontali A., Toure A.O., Garcia-Granero A., Roldan A.M., Larrainzar A.S., Ratnayake A.S., Gonzalez-Ganso A.M., Minaya-Bravo A.M., Das A., Bondurri A., Costanzi A., Lucchi A., Mazzari A., Musig A., Peloso A., Piano A., Police A., Mihailescu A., Pouy A., Romano A., Iossa A., Leonetti A.C., Guariniello A., Isaac A., Bovi A.P.D., Chessa A., Tromba A., Martinez A.A., Brillantino A., Caira A., Castaldi A., Ferronetti A., Giuliani A., Prestera A., la Medina A.R.-D., Tarasconi A., Tornambe A., Picciariello A., Ioannidis A., Leppaniemi A., Khan A., Rashid A., Perez-Sanchez A.L.E., Mittal A., Mitul A.R., Mehraj A., Laharwal A., Dorisme A., Marinis A., Iqbal A., Moncada A., Braccio B., Alkhafaji B., de Andres Asenjo B., Martin-Perez B., Perez B.S., Creavin B., Cali B., Pascotto B., Stubbs B., Retes B.Z., Jovanovic B., Goh B.K.P., Sensi B., Biddau C., Gazia C., Vallicelli C., Fagundes C.A., Santacruz C.C., Chirico C., Diaz C.J.G., Petrola C., Rodriguez C.S., Benitez C.Y., Dammaro C., Faro C.L., Reinke C., Paez C.D., Oliva C., Paranjape C., Thomas C., Chia C.F., Kong C.K., De Lucia C., Chao C.O., Arcudi C., Guerci C., Chia C., Parise C., Folliero C., Varela C., Ferguson D.M., Camacho D., Popowich D., Lima D.S., Rega D., Delogu D., Zigiotto D., Vinci D., D'Antonio D., Parini D., Merlini D.A., Zimmerman D.D.E., Moro-Valdezate D., Pertile D., Giusti D.M., Keller D.S., Tarik D., Kalivaci D., Mazingi D., Maldonado-Pintado D.G., Sasia D., Linardoutsos D., Osilli D., Murrone D., Russello D., Rodas E., Roa E.A.A., Ricciardi E., Rosso E., Saladino E., Flores-Villalba E., Ajs E.R., Smith-Singares E., Baili E., Kouroumpas E., Bourmpouteli E., Douka E., Martin-Perez E., Guaitoli E., Samadov E., Francone E., Vaterlini E., Morales E., Pena E., Zhao E., Andres E.D.P., Benzoni E., Erdas E., Pinotti E., Colas-Ruiz E., Aytac E., Laterza E., Agastra E., Foianini E., Moscoso E., Laviano E., Marra E., Cardamone E., Licardie E., Mpaili E., Pinna E., Varo E., Navarro F.M., Marino F., Medas F., Romano F., Maraska F., Saliu F., Madrid F., Rosa F., Mastella F., Gheza F., Luvisetto F., Alconchel F., Vieira F.M., Pareja F., Agresta F., Luna F., Bonilla F., Cordera F., Burdio F., Mendoza-Moreno F., Flores F.M., Aranda F.P., Taylor F., Ramos F.L., Fernandes F., Tropeano F.P., Balestra F., Bianco F., Ceci F., Colombo F., Di Marzo F., Ferrara F., Lancellotti F., Lazzarin F., Litta F., Martini F., Pizza F., Roscio F., Virdis F., Antona F.B., Ramirez F.C., Fernandez F.M., Llinares F.O., Quezada F., Schlottmann F., Herrera-Almario G., Massaferro G., Bislenghi G., van Ramshorst G., Luglio G., Bointas G., Kampouroglou G., Papadopoulos G., Manrique G.A., Calini G., Nastri G., Formisano G., Galiffa G., Palini G.M., Colucci G., Pagano G., Vanni G., Pattacini G.C., De Paola G., Lisi G., Partida G., Bellanova G., De Nobili G., Necchi G.S., Sinibaldi G., Tebala G., Bagaglini G., Izzo G., Argenio G., Brisinda G., Candilio G., Di Grezia G., Esposito G., Faillace G., Frazzetta G., La Gumina G., Nigri G., Romeo G., Amatriain G.C., Ortega G., Martin-Martin G., Stavrou G.A., Gunadi, Ugon G.A., Machain G., Marcucci G., Martinez-Mier G., Machain G.M., Nari G., Calvo H., Fathy H., Hamilto, Ahmed H., Faraj H., Nava H., Macias H.O., Nikaj H., Solano H., Khan H.A., Alarcon H.S., Ebied H., Giani I., Ateca I.V., Neri I., Roman I.A.S., Fidoshev I., Rodriguez I.M., Negoi I., Ortega I., Bernescu I., Russo I.S., Rodriguez I.V., Palomares I., Baltazar I., Torrejimeno I.J., Jurado I.M.C., Reccia I., Hussain I., Toledo I.B., Mora-Guzman I., Dogaru I., Romic I., Balciscueta I., Kenington J.C., Sagolsem J., Jang J.Y., Olivier J., Lammel-Lindemann J., Dziakova J., Villavicencio J.I.R., Salinas J., Parreira J.P.J.G., Jovanovic, Perez J.R., Reyes J.A.S., Luque J.A.M., Mak J., Rodriguez J.S., Kok J.H.H., Krook J., Diaz-Elizondo J.A., Castell J., Garcia-Flores J.E., Navalon J.M.J., Rodrigues J.M.S., Pereira J., Gomez J.T.C., Luque J.B., del Olmo J.C.M., Salamea J.C., Olivier J.F.C., Laina J.L.B., Ordonez J.M., Gutierrez J., Abba J., Sofi J.A., Sherafgan K., Sahnan K., Yanaga K., Beatson K., Asim L., Alvarez L., Siragusa L., Farber L., Ong L., Athanasios L., Garcia-Bruna L., De Martino L., Ferrario L., Giordano L., Gordini L., Pio L., Ponchietti L., Moletta L., Curella L., Poggi L., Taglietti L., Bonavina L., Conti L., Goffredi L., Ruiz L.A.G., Barrionuevo L., Fregoso L.E., Cabrera L.F., Rodriguez L.G., Grande L., Osoria L.G., Gonzalez L.J.K., Sanchez-Guillen L., Tallon-Aguilar L., Tresierra L., Giavarini L., Hasabelnabi M., Odovic M., Uemura M., Khan M., Artiles-Armas M., David M., Di Martino M., Spampinato M.G., Ribeiro M.A.F., Viola M., Angrisani M., Calussi M., Cannistra M., Catarci M., Cereda M., Conte M., Giordano M., Pellicciaro M., Marino M.V., Vaterlini M.E., Jimenez M.F., Lolli M.G., Bellini M.I., Lemma M., Chiarello M.M., Nicola M., Arrigo M., Mejia M.C., Manrique M.M., Rodriguez-Lopez M., Serradilla-Martin M., Lara M.Z., Martinez M., Bagnall M., Peter M., Lara M.C., Gomez M.J., Paniagua-Garcia-Senorans M., Gonzalez M.P., Rutegard M., Salo M., Franceschilli M., Silveri M., Veroux M., Pezzulo M., Nardi M., Rottoli M., Tolonen M., Ciro M.P., Zuluagua M., Cannavo M., Cervellera M., Iacobone M., Montuori M., Dominguez M.G., Bingol-Kologlu M., Tahir M., Lim M., Wilson M.S., Wilson M., Campanelli M., Bisaccia M., De Rosa M., Maruccia M., Paterno M., Pisano M., Torre M., Trevino M., Zuolo M., Hernandez Bartolome M.A., Farina M., Pera M., Calvo M.P., Sotelo M., Thway M.M., Hassan M., Hassan M.S.E., Azfar M., Bouhuwaish M., Taha M., Zaieem M., Korkoman M., Guraieb M., Shalaby M., Raza M.A., Younis M.U., Elhadi M., Ali M.Z., Quazi N., Dudi-Venkata N.N., Alselaim N., Loria N., Ramirez N.V., Than N.W., Smart N., Trelles N., Pinto N., Allievi N., Petrucciani N., Antonacci N., Cillara N., Gica N., Cristiana N.D., Krystek N., Falco N., Pecorelli N., Tamini N., Dallas N.A., Machairas N., Brito N., Fieturi N.A., Ortega N., Mercado O.A., Irkorucu O., Alsherif O., Valles O., Ioannidis O., Palmas O.H., Palmas O.I.H., Guadarrama O.S., Bozbiyik O., Omelanczuk P., Ottolino P., Rodrigues P., Ruiz P., Campenni P., Chiarade P., Olivares P.P., Baroffio P., Panaccio P., Wintringer P., Di Fronzo P., Talento P., Favoriti P., Sendino P., Marsanic P., Mifsut P., Andrade P., Ajawin P., Abadia-Barno P., Castaneda P.A.N., Arevalos P.O.S., Bellver P.P., Koh P.S., Souza P., Major P., Bali R.S., Khattar R.M., Melo R.B., Ebrahiminia R., Azar R., Murga R.L., Pirolo R., Brady R., Davies R.J., Dholakia R., Rattan R., Singhal R., Lim R., Angelico R., Isernia R.M., Tutino R., Faccincani R., Peltrini R., Carrera-Ceron R., Tejos R., Kashyap R., Fajardo R., Lozito R., Pareja R.M., Garbarino S., Morales-Conde S., Benli S., Mansour S., Flores S., Suarez S.L., Ben S.L., Fuentes S., Napetti S., de Guzman S.O., Awad S., Weckmann Lujan S.A., Gentilli S., Grimaldi S., Pizarro S.O., Tayar S., Nabi S., Chan S.M., Junaid S., Rojas S., Monetti S., Garcia S., Salvans S., Tenconi S., Shaw S., Santoni S., Parra S.A., Cardenas S., Perez-Bertolez S., Chiappetta S., Dessureault S., Delis S., Bonapasta S.A., Rausei S., Scaringi S., Keswani S., Ali S.M., Cetinkunar S., Fung T.L.D., Rawashdeh T., Lopez T.N., De Campos T., Duque T.C., Perra T., Liakakos T., Daskalakis T., Barnes T., Koeter T., Zalla T., Gonzalez T.E., Elosua T., Campagnaro T., Brown T., Luoto T., Oumar T.A., Giustizieri U., Grossi U., Bracale U., Rivas U., Sosa V., Testa V., Andriola V., Tonini V., Balassone V., Celentano V., Progno V., Raju V., Carroni V., Cavallaro V., Katta V.R., De Simone V., Romaguera V.P., Orozco V.H.G., Luraschi V., Rachkov V., Turrado-L V., Visag-Castillo V., Dowling V., Graham V., Papagni V., Vigorita V., Fonseca V.C., Carneros V.J., Bellato V., Goncalves W., Powers W.F., Grigg W., Bechstein W.O., Lim Y.B., Altinel Y., Golubovic Z., Balciscueta Z., Ielpo, B., Podda, M., Pellino, G., Pata, F., Caruso, R., Gravante, G., Di Saverio, S., Gallo, G., Lui, R., Orengia, A., Chowdary, A., Kulkarni, A., Kuvvetli, A., Navarro, A., Pisanu, A., Smith, A., Ibiricu, A. C., Nacion, A. J. D., Alsaleh, A., Alhazmi, A., Elmabri, A., Wani, A., Rencuzogullari, A., Lasarte, A. S., Rubio, A. V., Bavikatte, A., Kumar, A., Jamiri, A. -R., Padilla, A. M. A., Cacurri, A., de San Ildefonso, A., Porcu, A., Sartori, A., Rocca, A., Yanez, A. P., Becaria, A., Solis-Pena, A., Sretenovic, A., Urbistondo, A., Bandin, A., Najar, A., De Luca, A., Boddy, A., Charalabopoulos, A., Tzivanakis, A., Amendola, A., de Velasco, A. R. -G., Yildirim, A. C., Frontali, A., Toure, A. O., Garcia-Granero, A., Roldan, A. M., Larrainzar, A. S., Ratnayake, A. S., Gonzalez-Ganso, A. M., Minaya-Bravo, A. M., Das, A., Bondurri, A., Costanzi, A., Lucchi, A., Mazzari, A., Musig, A., Peloso, A., Piano, A., Police, A., Mihailescu, A., Pouy, A., Romano, A., Iossa, A., Leonetti, A. C., Guariniello, A., Isaac, A., Bovi, A. P. D., Chessa, A., Tromba, A., Martinez, A. A., Brillantino, A., Caira, A., Castaldi, A., Ferronetti, A., Giuliani, A., Prestera, A., la Medina, A. R. -D., Tarasconi, A., Tornambe, A., Picciariello, A., Ioannidis, A., Leppaniemi, A., Khan, A., Rashid, A., Perez-Sanchez, A. L. E., Mittal, A., Mitul, A. R., Mehraj, A., Laharwal, A., Dorisme, A., Marinis, A., Iqbal, A., Moncada, A., Braccio, B., Alkhafaji, B., de Andres Asenjo, B., Martin-Perez, B., Perez, B. S., Creavin, B., Cali, B., Pascotto, B., Stubbs, B., Retes, B. Z., Jovanovic, B., Goh, B. K. P., Sensi, B., Biddau, C., Gazia, C., Vallicelli, C., Fagundes, C. A., Santacruz, C. C., Chirico, C., Diaz, C. J. G., Petrola, C., Rodriguez, C. S., Benitez, C. Y., Dammaro, C., Faro, C. L., Reinke, C., Paez, C. D., Oliva, C., Paranjape, C., Thomas, C., Chia, C. F., Kong, C. K., De Lucia, C., Chao, C. O., Arcudi, C., Guerci, C., Chia, C., Parise, C., Folliero, C., Varela, C., Ferguson, D. M., Camacho, D., Popowich, D., Lima, D. S., Rega, D., Delogu, D., Zigiotto, D., Vinci, D., D'Antonio, D., Parini, D., Merlini, D. A., Zimmerman, D. D. E., Moro-Valdezate, D., Pertile, D., Giusti, D. M., Keller, D. S., Tarik, D., Kalivaci, D., Mazingi, D., Maldonado-Pintado, D. G., Sasia, D., Linardoutsos, D., Osilli, D., Murrone, D., Russello, D., Rodas, E., Roa, E. A. A., Ricciardi, E., Rosso, E., Saladino, E., Flores-Villalba, E., Ajs, E. R., Smith-Singares, E., Baili, E., Kouroumpas, E., Bourmpouteli, E., Douka, E., Martin-Perez, E., Guaitoli, E., Samadov, E., Francone, E., Vaterlini, E., Morales, E., Pena, E., Zhao, E., Andres, E. D. P., Benzoni, E., Erdas, E., Pinotti, E., Colas-Ruiz, E., Aytac, E., Laterza, E., Agastra, E., Foianini, E., Moscoso, E., Laviano, E., Marra, E., Cardamone, E., Licardie, E., Mpaili, E., Pinna, E., Varo, E., Navarro, F. M., Marino, F., Medas, F., Romano, F., Maraska, F., Saliu, F., Madrid, F., Rosa, F., Mastella, F., Gheza, F., Luvisetto, F., Alconchel, F., Vieira, F. M., Pareja, F., Agresta, F., Luna, F., Bonilla, F., Cordera, F., Burdio, F., Mendoza-Moreno, F., Flores, F. M., Aranda, F. P., Taylor, F., Ramos, F. L., Fernandes, F., Tropeano, F. P., Balestra, F., Bianco, F., Ceci, F., Colombo, F., Di Marzo, F., Ferrara, F., Lancellotti, F., Lazzarin, F., Litta, F., Martini, F., Pizza, F., Roscio, F., Virdis, F., Antona, F. B., Ramirez, F. C., Fernandez, F. M., Llinares, F. O., Quezada, F., Schlottmann, F., Herrera-Almario, G., Massaferro, G., Bislenghi, G., van Ramshorst, G., Luglio, G., Bointas, G., Kampouroglou, G., Papadopoulos, G., Manrique, G. A., Calini, G., Nastri, G., Formisano, G., Galiffa, G., Palini, G. M., Colucci, G., Pagano, G., Vanni, G., Pattacini, G. C., De Paola, G., Lisi, G., Partida, G., Bellanova, G., De Nobili, G., Necchi, G. S., Sinibaldi, G., Tebala, G., Bagaglini, G., Izzo, G., Argenio, G., Brisinda, G., Candilio, G., Di Grezia, G., Esposito, G., Faillace, G., Frazzetta, G., La Gumina, G., Nigri, G., Romeo, G., Amatriain, G. C., Ortega, G., Martin-Martin, G., Stavrou, G. A., Ugon, G. A., Machain, G., Marcucci, G., Martinez-Mier, G., Machain, G. M., Nari, G., Calvo, H., Fathy, H., Ahmed, H., Faraj, H., Nava, H., Macias, H. O., Nikaj, H., Solano, H., Khan, H. A., Alarcon, H. S., Ebied, H., Giani, I., Ateca, I. V., Neri, I., Roman, I. A. S., Fidoshev, I., Rodriguez, I. M., Negoi, I., Ortega, I., Bernescu, I., Russo, I. S., Rodriguez, I. V., Palomares, I., Baltazar, I., Torrejimeno, I. J., Jurado, I. M. C., Reccia, I., Hussain, I., Toledo, I. B., Mora-Guzman, I., Dogaru, I., Romic, I., Balciscueta, I., Kenington, J. C., Sagolsem, J., Jang, J. Y., Olivier, J., Lammel-Lindemann, J., Dziakova, J., Villavicencio, J. I. R., Salinas, J., Parreira, J. P. J. G., Perez, J. R., Reyes, J. A. S., Luque, J. A. M., Mak, J., Rodriguez, J. S., Kok, J. H. H., Krook, J., Diaz-Elizondo, J. A., Castell, J., Garcia-Flores, J. E., Navalon, J. M. J., Rodrigues, J. M. S., Pereira, J., Gomez, J. T. C., Luque, J. B., del Olmo, J. C. M., Salamea, J. C., Olivier, J. F. C., Laina, J. L. B., Ordonez, J. M., Gutierrez, J., Abba, J., Sofi, J. A., Sherafgan, K., Sahnan, K., Yanaga, K., Beatson, K., Asim, L., Alvarez, L., Siragusa, L., Farber, L., Ong, L., Athanasios, L., Garcia-Bruna, L., De Martino, L., Ferrario, L., Giordano, L., Gordini, L., Pio, L., Ponchietti, L., Moletta, L., Curella, L., Poggi, L., Taglietti, L., Bonavina, L., Conti, L., Goffredi, L., Ruiz, L. A. G., Barrionuevo, L., Fregoso, L. E., Cabrera, L. F., Rodriguez, L. G., Grande, L., Osoria, L. G., Gonzalez, L. J. K., Sanchez-Guillen, L., Tallon-Aguilar, L., Tresierra, L., Giavarini, L., Hasabelnabi, M., Odovic, M., Uemura, M., Khan, M., Artiles-Armas, M., David, M., Di Martino, M., Spampinato, M. G., Ribeiro, M. A. F., Viola, M., Angrisani, M., Calussi, M., Cannistra, M., Catarci, M., Cereda, M., Conte, M., Giordano, M., Pellicciaro, M., Marino, M. V., Vaterlini, M. E., Jimenez, M. F., Lolli, M. G., Bellini, M. I., Lemma, M., Chiarello, M. M., Nicola, M., Arrigo, M., Mejia, M. C., Manrique, M. M., Rodriguez-Lopez, M., Serradilla-Martin, M., Lara, M. Z., Martinez, M., Bagnall, M., Peter, M., Lara, M. C., Gomez, M. J., Paniagua-Garcia-Senorans, M., Gonzalez, M. P., Rutegard, M., Salo, M., Franceschilli, M., Silveri, M., Veroux, M., Pezzulo, M., Nardi, M., Rottoli, M., Tolonen, M., Ciro, M. P., Zuluagua, M., Cannavo, M., Cervellera, M., Iacobone, M., Montuori, M., Dominguez, M. G., Bingol-Kologlu, M., Tahir, M., Lim, M., Wilson, M. S., Wilson, M., Campanelli, M., Bisaccia, M., De Rosa, M., Maruccia, M., Paterno, M., Pisano, M., Torre, M., Trevino, M., Zuolo, M., Hernandez Bartolome, M. A., Farina, M., Pera, M., Calvo, M. P., Sotelo, M., Thway, M. M., Hassan, M., Hassan, M. S. E., Azfar, M., Bouhuwaish, M., Taha, M., Zaieem, M., Korkoman, M., Guraieb, M., Shalaby, M., Raza, M. A., Younis, M. U., Elhadi, M., Ali, M. Z., Quazi, N., Dudi-Venkata, N. N., Alselaim, N., Loria, N., Ramirez, N. V., Than, N. W., Smart, N., Trelles, N., Pinto, N., Allievi, N., Petrucciani, N., Antonacci, N., Cillara, N., Gica, N., Cristiana, N. D., Krystek, N., Falco, N., Pecorelli, N., Tamini, N., Dallas, N. A., Machairas, N., Brito, N., Fieturi, N. A., Ortega, N., Mercado, O. A., Irkorucu, O., Alsherif, O., Valles, O., Ioannidis, O., Palmas, O. H., Palmas, O. I. H., Guadarrama, O. S., Bozbiyik, O., Omelanczuk, P., Ottolino, P., Rodrigues, P., Ruiz, P., Campenni, P., Chiarade, P., Olivares, P. P., Baroffio, P., Panaccio, P., Wintringer, P., Di Fronzo, P., Talento, P., Favoriti, P., Sendino, P., Marsanic, P., Mifsut, P., Andrade, P., Ajawin, P., Abadia-Barno, P., Castaneda, P. A. N., Arevalos, P. O. S., Bellver, P. P., Koh, P. S., Souza, P., Major, P., Bali, R. S., Khattar, R. M., Melo, R. B., Ebrahiminia, R., Azar, R., Murga, R. L., Pirolo, R., Brady, R., Davies, R. J., Dholakia, R., Rattan, R., Singhal, R., Lim, R., Angelico, R., Isernia, R. M., Tutino, R., Faccincani, R., Peltrini, R., Carrera-Ceron, R., Tejos, R., Kashyap, R., Fajardo, R., Lozito, R., Pareja, R. M., Garbarino, S., Morales-Conde, S., Benli, S., Mansour, S., Flores, S., Suarez, S. L., Ben, S. L., Fuentes, S., Napetti, S., de Guzman, S. O., Awad, S., Weckmann Lujan, S. A., Gentilli, S., Grimaldi, S., Pizarro, S. O., Tayar, S., Nabi, S., Chan, S. M., Junaid, S., Rojas, S., Monetti, S., Garcia, S., Salvans, S., Tenconi, S., Shaw, S., Santoni, S., Parra, S. A., Cardenas, S., Perez-Bertolez, S., Chiappetta, S., Dessureault, S., Delis, S., Bonapasta, S. A., Rausei, S., Scaringi, S., Keswani, S., Ali, S. M., Cetinkunar, S., Fung, T. L. D., Rawashdeh, T., Lopez, T. N., De Campos, T., Duque, T. C., Perra, T., Liakakos, T., Daskalakis, T., Barnes, T., Koeter, T., Zalla, T., Gonzalez, T. E., Elosua, T., Campagnaro, T., Brown, T., Luoto, T., Oumar, T. A., Giustizieri, U., Grossi, U., Bracale, U., Rivas, U., Sosa, V., Testa, V., Andriola, V., Tonini, V., Balassone, V., Celentano, V., Progno, V., Raju, V., Carroni, V., Cavallaro, V., Katta, V. R., De Simone, V., Romaguera, V. P., Orozco, V. H. G., Luraschi, V., Rachkov, V., Turrado-L, V., Visag-Castillo, V., Dowling, V., Graham, V., Papagni, V., Vigorita, V., Fonseca, V. C., Carneros, V. J., Bellato, V., Goncalves, W., Powers, W. F., Grigg, W., Bechstein, W. O., Lim, Y. B., Altinel, Y., Golubovic, Z., Balciscueta, Z., Ielpo, B, Podda, M, Pellino, G, Pata, F, Caruso, R, Gravante, G, Di Saverio, S, and Luglio, G
Subjects: medicine.medical_specialty, Anti-Bacterial Agents, Appendectomy, Appendicitis, COVID-19 Testing, Hospital Administration, Humans, Pandemics, Personal Protective Equipment, Practice Patterns, Physicians', Surveys and Questionnaires, Attitude of Health Personnel, COVID-19, Surgeons, Coronavirus disease 2019 (COVID-19), Settore MED/18 - CHIRURGIA GENERALE, COVID-19 pandemic. Acute appendicitis, MEDLINE, Practice Patterns, 030230 surgery, Health administration, 03 medical and health sciences, 0302 clinical medicine, Anti-Bacterial Agent, Pandemic, medicine, Surveys and Questionnaire, Appendiciti, General, Laparoscopy, Personal protective equipment, Physicians', medicine.diagnostic_test, business.industry, General surgery, Original Articles, medicine.disease, Anti-bacterial agents, appendectomy, appendicitis, COVID-19 testing, hospital administration, humans, pandemics, personal protective equipment, practice patterns physicians', surveys and questionnaires, attitude of health personnel, surgeons, appendicitis - COVI-19 - ACIE study - management, Acute appendicitis, Original Article, Surgery, Covid-19, business, Human
Abstract: Background Surgical strategies are being adapted to face the COVID‐19 pandemic. Recommendations on the management of acute appendicitis have been based on expert opinion, but very little evidence is available. This study addressed that dearth with a snapshot of worldwide approaches to appendicitis. Methods The Association of Italian Surgeons in Europe designed an online survey to assess the current attitude of surgeons globally regarding the management of patients with acute appendicitis during the pandemic. Questions were divided into baseline information, hospital organization and screening, personal protective equipment, management and surgical approach, and patient presentation before versus during the pandemic. Results Of 744 answers, 709 (from 66 countries) were complete and were included in the analysis. Most hospitals were treating both patients with and those without COVID. There was variation in screening indications and modality used, with chest X‐ray plus molecular testing (PCR) being the commonest (19·8 per cent). Conservative management of complicated and uncomplicated appendicitis was used by 6·6 and 2·4 per cent respectively before, but 23·7 and 5·3 per cent, during the pandemic (both P, The COVID‐19 pandemic required reorganization of surgical services, affecting patients with common surgical diseases including acute appendicitis. No evidence is available on the topic. This study found global variation in screening policies, use of personal protective equipment and intraoperative directives. There has been increased adoption of non‐operative management and open appendicectomy. Hands off
Published: 2021

24. Easy Access to Phosphine-Borane Building Blocks

Author: Koop Lammertsma, J. Chris Slootweg, Martin Lutz, G. Bas de Jong, Nuria Ortega, Synthetic Organic Chemistry (HIMS, FNWI), Chemistry and Pharmaceutical Sciences, and AIMMS
Subjects: 2019-20 coronavirus outbreak, synthesis, primary phosphine, Solid-state, Borane, 010402 general chemistry, 01 natural sciences, Catalysis, Inorganic Chemistry, chemistry.chemical_compound, crystal structures, Deprotonation, Moiety, phosphanediide, Protecting group, Alkyl, chemistry.chemical_classification, Full Paper, 010405 organic chemistry, Organic Chemistry, General Chemistry, Full Papers, Combinatorial chemistry, 0104 chemical sciences, chemistry, phosphine borane, SDG 6 - Clean Water and Sanitation, Phosphine
Abstract: In this paper, we highlight the synthesis of a variety of primary phosphine‐boranes (RPH2⋅BH3) from the corresponding dichlorophosphines, simply by using Li[BH4] as reductant and provider of the BH3 protecting group. The method offers facile access not only to alkyl‐ and arylphosphine‐boranes, but also to aminophosphine‐boranes (R2NPH2⋅BH3) that are convenient building blocks but without the protecting BH3 moiety thermally labile and notoriously difficult to handle. The borane‐protected primary phosphines can be doubly deprotonated using n‐butyllithium to provide soluble phosphanediides Li2[RP⋅BH3] of which the phenyl‐derivative Li2[PhP⋅BH3] was structurally characterized in the solid state., A range of differently substituted primary phosphine‐boranes (RPH2⋅BH3) are now accessible that as unprotected phosphines difficult to handle or even unstable. In particular, the synthesis of the aminophosphane‐boranes (R2NPH2⋅BH3) offers new opportunities to use as versatile building blocks in the syntheses of organophosphorus compounds.
Published: 2020

25. Linfadenectomía lateral pélvica en neoplasia de recto inferior

Author: Nuria Ortega Torrecilla, Núria Gómez Romeu, and Ramón Farrés Coll
Subjects: General Materials Science
Abstract: Presentamos el caso clínico de una mujer de 53 años sin alergias medicamentosas y con único antecedente de hipertensión arterial que consultó al servicio de digestivo por 4 meses de rectorragias asociada a tumefacción a nivel anal. Se derivó a la consulta de cirugía colorrectal por sospecha de posible neoplasia rectal. A la inspección anal y tacto rectal se palpaba una lesión indurada e inmóvil a 2 cm de margen anal (MA) estenosante y polipoidea que se exteriorizaba a través del ano.
Published: 2020

26. Smartphone augmented information for museums with BLE localization

Author: Fernando Seco, Antonio Jiménez, and Nuria Ortega Sánchez
Subjects: Localización, Fuerza de señal recibida, Physics, computer.internet_protocol, Context (language use), Persona, BLE beacons, Low energy, Estimación Bayesiana, Signal strength, Localization, Bayes estimation, computer, Humanities, Balizas BLE, Bluetooth Low Energy
Abstract: [Resumen] Presentamos el diseño y desarrollo de una solución para el guiado contextualizado durante visitas a museos. Para ello se han distribuido por el entorno balizas de tipo Bluetooth Low Energy (BLE), de las cuales el smartphone lee las medidas de potencia recibida (RSS), junto con información de los sensores de acelerómetro y magnetómetro. Con la información sensorial y la del contexto, previamente almacenada en la nube, la app estima la ubicación de la persona en el recinto del museo con sus diferentes salas, y es capaz de calcular la distancia y la orientación de la persona respecto a los cuadros de interés. La precisión en la capacidad para medir estos parámetros es analizada utilizando diferentes métodos de trilateración usando filtros de Kalman extendidos (EKF) con integración débil y acoplada. Los resultados de localización obtenidos nos permiten tener suficiente precisión como para poder guiar al usuario en búsqueda de un cuadro o ruta de cuadros recomendada, o también para dar la información del cuadro más cercano en la dirección de visualización de usuario. El potencial uso e impacto de este enfoque se puede extender a otras aplicaciones en sectores industriales o robóticos que requieran asistencia o guiado en la búsqueda de objetos [Abstract] We present the design and development of a solution for a contextualized guidance during visits to museums. Several Bluetooth Low Energy (BLE) beacons have been distributed around the environment, from which the smartphone reads the Received Signal Strenght (RSS), together with information from the accelerometer and magnetometer sensors. We use the RSS data and the context information previously stored in the cloud, to estimate the smartphone's localization or pose of the person in the museum. The location is used to calculate the distance and orientation of the person with respect to the pictures of interest. The accuracy in the ability to measure these parameters is analyzed using different trilateration methods using extended Kalman filters (EKF) with loose and tightcoupled integration. The localization performance obtained allow us to have enough precision to be able to guide the user in search of a recommended picture, or also to give the information of the nearest frame in the user's viewing direction. The potential use and impact of this approach can be extended to other applications in industrial or robotic sectors that require instruments to search objects of interest. Ministerio de Economía y Competitividad; TIN2015-71564-C4-2-R Ministerio de Economía, Industria y Competitividad; TEC2015-71426-REDT
Published: 2020

27. Cost analysis of the management of brain metastases in patients with advanced ALK+ NSCLC: alectinib versus crizotinib

Author: Nuria Ortega-Joaquín, M. Lázaro, Dolores Isla, Rocío Gordo, Bartomeu Massuti, Itziar Oyagüez, and Lucía Ruiz de Alda
Subjects: Pulmonary and Respiratory Medicine, Alectinib, Oncology, medicine.medical_specialty, economic evaluation, Short Communication, costs, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, alectinib, In patient, 030212 general & internal medicine, metastasis CNS, Lung cancer, Average cost, ALK NSCLC, crizotinib, Crizotinib, business.industry, Incidence (epidemiology), medicine.disease, 030220 oncology & carcinogenesis, Cost analysis, business, medicine.drug, Brain metastasis
Abstract: Aim: To estimate management cost of NSCLC ALK+ patients with and without brain metastasis (BM), and to compare annual costs in patients treated with alectinib or crizotinib. Methods: Management cost/year (€ 2018) in patients with and without BM was estimated with disaggregated resource consumption provided by local oncologists, including medical visits, hospitalizations, diagnostic/laboratory tests, imaging techniques and surgical procedures. The comparison of costs/year with alectinib and crizotinib, considered the cumulative 12-month incidence of BM in ALEX trial (9.4 and 41.4%, respectively). Results: Management cost was €6173.42/patient-year without BM and €21,637.50/patient-year with BM. With alectinib, average cost/patient was lower than crizotinib (€4948.51/patient-year) Conclusion: Prevention of BM with alectinib may result in reductions of cost/year in the management of advanced ALK+ NSCLC.
Published: 2020

28. Postherpetic Pseudohernia

Author: Anna Curell, Nuria Ortega, Gian Pier Protti, Jose María Balibrea, and Manuel López-Cano
Subjects: General Engineering
Published: 2019

29. Las infancias sonoras

Author: Nuria Ortega Riba and Nuria Ortega Riba
Abstract: Premio Adonáis 2021 por «la naturalidad con la que actualiza la tradición, la vuelta de tuerca expresiva que aplica al lenguaje coloquial y la mirada de asombro sobre el mundo y la memoria», rasgos que, a juicio del jurado, la hacen digna de este galardón. Como se podrá advertir, la de Nuria Riba es poesía que se desenvuelve en un universo muy concreto, el de su familia y el de sus nostalgias, inseguridades y experiencias cotidianas de vida, desgranadas desde el recuerdo, su aliado principal, En él se suceden diversos acontecimientos minúsculos, pero decisivos, audibles, para quien, como la autora, indaga en la realidad a partir de sus propios vínculos emocionales, basados preferentemente en un «antes» y comprendidos en un «ahora». A la vez, es poesía con un afán enorme por nombrar: las mismas palabras son capaces de darle sentido a sus pálpitos interiores y configuran, desde su insuficiencia, el único modo posible de iluminar la existencia. Escrita desde una enternecedora e ingenua sencillez, el presente libro es una invitación a lo inesperado, a lo sorpresivo, a lo ocurrente y a todo aquello que nos devuelve a nuestro estado de primigenia inocencia y candidez.
Published: 2022

30. Surgeons' fear of getting infected by COVID19: A global survey

Author: An, Yongbo, primary, Bellato, Vittoria, additional, Konishi, Tsuyoshi, additional, Pellino, Gianluca, additional, Sensi, Bruno, additional, Siragusa, Leandro, additional, Franceschilli, Marzia, additional, Sica, Giuseppe S, additional, Kefleyesus, A, additional, Hoofwijk, A G M, additional, Eldaly, Abdullah Sami, additional, Gonzalez, Abel, additional, Jawad, Adraoui, additional, Jooma, Ahmad, additional, Hafez, Ahmed Mousa, additional, Rubio, Ainhoa Valle, additional, Landaluce-Olavarria, Aitor, additional, Wu, Aiwen, additional, Nagatsu, Akihisa, additional, Inoue, Akira, additional, Kanamoto, Akira, additional, Ouchi, Akira, additional, El-Hussuna, Alaa, additional, Vazquez-Melero, Alba, additional, Wolthuis, Albert M, additional, Peral, Alberto M, additional, Lozano, Alejandra Cruz, additional, Efremov, Aleksandr, additional, Ryasantsev, Aleksandr V, additional, Di Giorgio, Alessandra, additional, Parente, Alessandro, additional, Tamburrini, Alessandro, additional, Alò, Alessio, additional, Forero-Torres, Alexander, additional, Vahrmeijer, Alexander L, additional, Varabei, Alexander, additional, Hinojosa, Siles, additional, Balkan, Ali Zeynel Abidin, additional, Frontali, Alice, additional, Oleg, Alikin, additional, Soler-Silva, Álvaro, additional, Makni, Amin, additional, André, Ana, additional, Cabrera, Ana María García, additional, Fernández, Ana María Gonzalez, additional, Minaya-Bravo, Ana M, additional, Rodríguez-Sánchez, Ana, additional, Musina, Ana-Maria, additional, Pangeni, Anang, additional, Zolotko, Anastasia, additional, Tonoyan, Andranik, additional, Balla, Andrea, additional, Belli, Andrea, additional, Cavallaro, Andrea, additional, Chierici, Andrea, additional, Divizia, Andrea, additional, Bucci, Andrea Fares, additional, Salido, Andrea Jiménez, additional, Morini, Andrea, additional, Muratore, Andrea, additional, Vignali, Andrea, additional, Chitul, Andrei, additional, Sebastian, Diaconescu Andrei, additional, Pcolkins, Andrejs, additional, Shchegolev, Andrey, additional, Hollenbeck, Andrew, additional, Wisneski, Andrew, additional, Iossa, Angelo, additional, D'Amore, Anna, additional, Hunter, Anndrew, additional, Hesketh, Anthony J, additional, La Brocca, Andrea, additional, Spinelli, Antonino, additional, Caires, Antonio, additional, D'Alessandro, Antonio, additional, Correo, Antonio Francisco Sanchís López, additional, Macrì, Antonio, additional, Navarro-Sánchez, Antonio, additional, Pronk, Apollo, additional, Akunc, Aram, additional, Mehri, Arash, additional, Pelta, Arie, additional, Papadopoulos, Aristeidis, additional, Kechagias, Aristotelis, additional, Rashid, Arshad, additional, Ramazanov, Artur, additional, Chandio, Ashfaq, additional, Kohyama, Atsushi, additional, Nishimura, Atsushi, additional, Ohkawa, Atsushi, additional, Dulskas, Audrius, additional, Jamal, Aun, additional, Mariani, Aurora, additional, Unal, Ayse Gizem, additional, Karagoz, Ayse, additional, Ozkan, Bahar Busra, additional, Salih, Barham, additional, Gülcü, Baris, additional, Pessia, Beatrice, additional, Martin-Perez, Beatriz, additional, Ielpo, Benedetto, additional, Tulelli, Berenice, additional, Yang, Bin, additional, Mhamed, Boumadani, additional, Murphy, Brenda, additional, Pirozzi, Brunella Maria, additional, Langenhoff, Bs, additional, Belevi, Bulent, additional, Güney, Burak, additional, Ng, Caecilia, additional, Rueda, Camilo, additional, Roxburgh, Campbell S, additional, Feo, Carlo V, additional, Ferrari, Carlo, additional, Gazia, Carlo, additional, Pratesi, Carlo, additional, Ratto, Carlo, additional, Santacruz, Carlos Cerdán, additional, Arroyave, Carlos Rodolfo Martinez, additional, Macias, Carlos, additional, Fernandez, Carlota Garcia, additional, Fernandez, Carmen Cagigas, additional, Curtis-Martinez, Carolina, additional, Fortmann, Caroline, additional, Kim, Caroline, additional, Galeano, Catalina Uribe, additional, Barroso, Catarina, additional, Baldi, Caterina, additional, Foppa, Caterina, additional, Formisano, Cesare, additional, Li, Changzai, additional, Ding, Chao, additional, Wang, Chenyu, additional, Iacusso, Chiara, additional, Yang, Chongwei, additional, Pizzera, Christian, additional, Skias, Christoph, additional, Chouliras, Christos, additional, Liakos, Christos, additional, Matsuda, Chu, additional, Wu, Chun-yi, additional, Ozaslan, Cihangir, additional, Tanda, Cinzia, additional, Tommaso, Cipolat Mis, additional, Dagorno, Claire, additional, Ramos, Claudia Patricia Arellano, additional, Arcudi, Claudio, additional, Coco, Claudio, additional, Morales, Cleotilde Mateo, additional, Ali, Mujahid Zulfiqar, additional, Lozano, Coral Cózar, additional, Sala, Corrado, additional, Leo, Cosimo Alex, additional, Scarpa, Cosimo Riccardo, additional, Ferro, Cristian Varela, additional, Fernandez, Cristina Mosquera, additional, Morales-Garcia, D, additional, Nakano, Daisuke, additional, Cristian, Daniel, additional, Hechtl, Daniel, additional, Cánovas, Daniel Triguero, additional, Calabrese, Daniela, additional, Rega, Daniela, additional, Ferraro, Daniele, additional, Morezzi, Daniele, additional, Sommacale, Daniele, additional, Brogden, Danielle, additional, Miskovic, Danilo, additional, Merlini, David, additional, Pertile, Davide, additional, Coniglio, Denise, additional, Zhu, Dexiang, additional, Wu, Dianwen, additional, Coletta, Diego, additional, Rubio, Diego Ramos, additional, Sasia, Diego, additional, Fillipov, Dmitry, additional, Russiello, Domenico, additional, Dardanov, Dragomir, additional, Consten, E C J, additional, Smolskas, Edgaras, additional, Muttillo, Edoardo Maria, additional, Jones, Edward, additional, Sunami, Eiji, additional, Etienne, El-Helou, additional, Chalkiadaki, Elena, additional, Giacomelli, Elena, additional, Karbovnichaya, Elena, additional, Ruiz-Úcar, Elena, additional, Guaitoli, Eleonora, additional, Samadov, Elgun, additional, Jovine, Elio, additional, Treppiedi, Elio, additional, Vaterlini, Elisa Maria, additional, Zambaiti, Elisa, additional, Moggia, Elisabetta, additional, Coetzee, Elmi, additional, Chisari, Emanuele, additional, D'Errico, Emanuele, additional, Ciofic, Emilia, additional, Peña, Emilio, additional, Kurt, Emine, additional, Balık, Emre, additional, Gunay, Emre, additional, Sivrikoz, Emre, additional, Andolfi, Enrico, additional, Araimo, Enrico, additional, Lucci, Enrico, additional, Opocher, Enrico, additional, Pinotti, Enrico, additional, Rubino, Enrico, additional, Reyhan, Enver, additional, Mazzotta, Erica, additional, Navarro, Ernesto Barzola, additional, El-Helou, Etienne, additional, Licardie-Bolaños, Eugenio, additional, Porto, Eva Iglesias, additional, Contreras, Evelyn, additional, Boerma, Evert-Jan, additional, Cianchi, Fabio, additional, Marino, Fabio, additional, Uggeri, Fabio, additional, Han, Fanghai, additional, Calculli, Federica, additional, Falaschi, Federica, additional, Ghignone, Federico, additional, Perrone, Federico, additional, Borghi, Felice, additional, García, Felipe, additional, Agresta, Ferdinando, additional, Cananzi, Ferdinando Carlo Maria, additional, Mendoza-Moreno, Fernando, additional, Cengiz, Fevzi, additional, Almeida, Filipe Macedo, additional, Baracchi, Filippo, additional, Carannante, Filippo, additional, La Torre, Filippo, additional, Fernandes, Flavio, additional, Friedmacher, Florian, additional, Grama, Florin, additional, Carissimi, Francesca, additional, Pecchini, Francesca, additional, Bianco, Francesco, additional, Colombo, Francesco, additional, Ferrara, Francesco, additional, Litta, Francesco, additional, Carrano, Francesco Maria, additional, Martignoni, Francesco, additional, Tasselli, Francesco Menegon, additional, Milone, Francesco, additional, Pata, Francesco, additional, Sammartino, Francesco, additional, Zambianchi, Francesco, additional, Barragan, Francisco, additional, Herrero, Francisco, additional, Schlottmann, Francisco, additional, Den Boer, Frank C, additional, Pfeffer, Frank, additional, Fujita, Fumihiko, additional, Navarra, G, additional, Herrera-Almario, Gabriel, additional, Pozzo, Gabriele, additional, Capolupo, Gabriella Teresa, additional, Van Ramshorst, Gabrielle H, additional, Liscia, Gadiel, additional, Gallo, Gaetano, additional, Asawa, Ganesh, additional, Wang, Gaoxiang, additional, Raiyani, Gaurang, additional, Beets, Geerard, additional, Naval, Gemma Sugrañes, additional, Jin, Genfeng, additional, Chang, George J, additional, Saakian, George, additional, Kahane, Gerardo, additional, Borroni, Giacomo, additional, Lo Secco, Giacomo, additional, Baiocchi, Gian Luca, additional, Baronio, Gianluca, additional, Pagano, Gianluca, additional, Pattacini, Gianmaria Casoni, additional, Lisi, Giorgio, additional, Milito, Giovanni, additional, Sinibaldi, Giovanni, additional, Serrao, Giuditta, additional, Bagaglini, Giulia, additional, Sarro, Giuliano, additional, Brisinda, Giuseppe, additional, Candilio, Giuseppe, additional, Mangiameli, Giuseppe, additional, Giuliani, Giuseppe, additional, Martin-Martin, Gonzalo Pablo, additional, Bodzin, Gordon, additional, Leon, Graat, additional, Mackay, Graham, additional, Vasil, Granila, additional, Palmisano, Graziano, additional, Giovanna, Grella Maria, additional, Fernández, Guadalupe Campos, additional, Steingel, Guillermo Berrones, additional, Zhang, Guoyun, additional, Choi, Gyu Seog, additional, Chen, Haipeng, additional, Hirose, Hajime, additional, Kayano, Hajime, additional, Ulgur, Hanife Seyda, additional, Impellizzeri, Harmony, additional, Ariola, Hasani, additional, Liu, Heli, additional, Medina, Heriberto, additional, Miyauchi, Hideaki, additional, Takahashi, Hidekazu, additional, Hayashi, Hideki, additional, Ishikawa, Hideki, additional, Ishida, Hideyuki, additional, De Vries, Hilbert, additional, Ulman, Hilmican, additional, Kon, Hirofumi, additional, Ota, Hirofumi, additional, Akamatsu, Hiroki, additional, Tamagawa, Hiroshi, additional, Shoji, Hirotaka, additional, Egi, Hiroyuki, additional, Matsubara, Hisahiro, additional, Miki, Hisanori, additional, Elfeki, Hossam, additional, Lin, Hung-Hsin, additional, Giani, Iacopo, additional, Caravaca-García, Iban, additional, Takemasa, Ichiro, additional, Angriman, Imerio, additional, Negoi, Ionut, additional, Volkova, Irina, additional, Russo, Iris, additional, Kronberger, Irmgard E, additional, Shageev, Iskander, additional, Aydin, Ishak, additional, Mora Guzmán, Ismael, additional, Novak, Ivana, additional, Giuliano, Izzo, additional, Rachmuth, Jacob, additional, Ngu, James Chi-Yong, additional, Glasbey, James, additional, Stoot, Jan, additional, Žatecky, Jan, additional, Melenhorst, Jarno, additional, Van Der Wal, J B C, additional, Leijtens, Jeroen, additional, Bogach, Jessica, additional, Elliott, Jessie, additional, De Wilt, J H W, additional, Han, Jiagang, additional, Cui, Jian, additional, Liu, Jiaqi, additional, Khan, Jim, additional, Wirawan, Jimmy Panji, additional, Zhang, Jinji, additional, Manyari, Joel Davis Osorio, additional, Doerner, Johannes, additional, Bock, Jonathan, additional, Konsten, Joop, additional, Castro, Jorge Mario, additional, Grobas, Jorge Pérez, additional, Pereira, José, additional, Juloski, Jovan, additional, Laina, Juan Luis Blas, additional, Solórzano, Juan José, additional, López, Juan Ramón Gómez, additional, Li, Jun, additional, Watanabe, Jun, additional, Kwak, Jung-Myun, additional, Hasegawa, Junichi, additional, Hiro, Junichiro, additional, Sergey, K, additional, Zhang, Kai, additional, Nagahori, Kaoru, additional, Martinez, Karla, additional, Tokuhara, Katsuji, additional, Danno, Katsuki, additional, Uehara, Kay, additional, Yoshimatsu, Kazuhiko, additional, Ehara, Kazuhisa, additional, Ueda, Kazuki, additional, Suda, Kazuyoshi, additional, Yamamoto, Kazuyuki, additional, Ishimaru, Kei, additional, Kimura, Kei, additional, Hirata, Keiji, additional, Deen, Kemal, additional, Imaizumi, Ken, additional, Yamada, Jenji, additional, Tanakura, Kenta, additional, Rida, Khaled, additional, Sugimoto, Kiichi, additional, Kotaro, Kitani, additional, Shi, Kiwisure, additional, Okabayashi, Koji, additional, Hida, Koya, additional, Kataoka, Kozo, additional, Hongo, Kumiko, additional, Xia, Kunkun, additional, Tseng, Larissa, additional, Reime, Lars, additional, Lorenzon, Laura, additional, Ruano, Laura Muiños, additional, Zhou, Lei, additional, De Nes, Lindsey, additional, Brandariz, Lorena, additional, Morini, Lorenzo, additional, Petagna, Lorenzo, additional, Ripamonti, Lorenzo, additional, Martinez, Lourdes Hernandez, additional, Pio, Luca, additional, Sacco, Luca, additional, Carvalho, Lucia, additional, Zorcolo, Luigi, additional, Pérez-Sánchez, Luis Eduardo, additional, Esparza, Luis Humberto Reyes, additional, Aguilar, Luis Tallon, additional, Garner, Madeleine, additional, Sugimoto, Maki, additional, Nagashima, Makoto, additional, Shiozawa, Manabu, additional, Simone, Manfredelli, additional, Ferrer-Marquez, Manuel, additional, Carvalho, Marcia, additional, Alifano, Marco, additional, Arganini, Marco, additional, Calussi, Marco, additional, Catarci, Marco, additional, Allaix, Marco Ettore, additional, Forlin, Marco, additional, Milone, Marco, additional, Paci, Marco, additional, Fodor, Margot, additional, Antipova, Maria, additional, Martos, Maria Beltran, additional, Giuffrida, Maria Carmela, additional, Tabernilla, María Diez, additional, Quirós, María José Alcaide, additional, Lemma, Maria, additional, Correo, Maria Luisa Reyes Diaz, additional, Małowiecka, Maria, additional, Bellomo, Maria Paola, additional, Fernandez, Maria Ramos, additional, Socias, María, additional, Rizk, Mariam, additional, Aurora, Mariani, additional, Antolinez, Mariano Alvarez, additional, Ninkovic, Marijana, additional, Giuffrida, Mario, additional, De Roos, Marnix A J, additional, Lara, Marta Cañón, additional, Agustin, Marta Climent, additional, Cuadrado, Marta, additional, Pascual, Marta, additional, Lemmerer, Martina, additional, Carlos, R, additional, Okamoto, Masa, additional, Miyo, Masaaki, additional, Inomata, Masafumi, additional, Ikenaga, Masakazu, additional, Tsujie, Masaki, additional, Yasuno, Masamichi, additional, Kotake, Masanori, additional, Sato, Masanori, additional, Yasui, Masayoshi, additional, Lavazza, Matteo, additional, Rottoli, Matteo, additional, Zuin, Matteo, additional, Zuluaga, Mauricio, additional, Cervellera, Maurizio, additional, Cesari, Maurizio, additional, Zizzo, Maurizio, additional, Garino, Mauro, additional, Ghirardi, Mauro, additional, Montuori, Mauro, additional, Podda, Mauro, additional, Santarelli, Mauro, additional, Koc, Mehmet Ali, additional, Baini, Melissa, additional, Campanelli, Michela, additional, Manigrasso, Michele, additional, Zuolo, Michele, additional, Cunha, Miguel F, additional, Misca, Mihaela, additional, Slavchev, Mihail, additional, Danilov, Mikhail, additional, Shigaev, Mikhail, additional, Martens, Milou, additional, Kobayashi, Minako, additional, Ren, Mingyang, additional, Ishizuka, Mitsuru, additional, Hassan, Mohammed Mustafa, additional, Siblini, Mohamad, additional, Sahloul, Mohamed, additional, Keramati, Mohammad Reza, additional, Karunakaran, Monish, additional, Markel, Moritz, additional, Majeed, Mudassar, additional, Younis, Muhammad Umar, additional, Akin, Muhammed Ikbal, additional, Laraibe, Munazza, additional, Derebey, Murat, additional, Kendirci, Murat, additional, Fukunaga, Mutsumi, additional, Matsubara, Nagahide, additional, Ordaz, Narce Eunice Cruz, additional, Samalavicius, Narimantas Evaldas, additional, Keeratibharat, Nattawut, additional, Angelis, Nicola, additional, Gica, Nicolae, additional, Mariani, Nicoló Maria, additional, Ramino, Nicolò, additional, Falco, Nicolò, additional, Smart, Neil, additional, De Korte, Niels, additional, Kok, Niels F M, additional, Jamieson, Nigel B, additional, Aberyasev, Nikolay, additional, Bruklich, Nikolay, additional, Ichikawa, Nobuki, additional, Miyoshi, Norikatsu, additional, De Palma, Norma, additional, Figueiredo, Nuno, additional, Torrecilla, Nuria Ortega, additional, Dybov, Oleg G, additional, Yudin, Oleg, additional, Crepin, Ollende, additional, Gomez, Oscar, additional, Sert, Ozlem Zeliha, additional, Lominchar, Pablo Lozano, additional, Menéndez, Pablo, additional, De Nardi, Paola, additional, Tejedor, Patricia, additional, Jordan, Patrick, additional, Tan, Patrick, additional, Marsanic, Patrizia, additional, Natalya, Pechnikova, additional, Baños, Pedro Parra, additional, Rebasa, Pere, additional, Neary, Peter M, additional, Tanis, Pieter, additional, Giustacchini, Piero, additional, Anoldo, Pietro, additional, Concejo, Pilar, additional, Cao, Pin, additional, Chandrasinghe, Pramodh, additional, Abeyratne, Prasad, additional, Wang, Quan, additional, Klicks, R J, additional, Riquelme, Rafael Ferrer, additional, De Luca, Raffaele, additional, Galli, Raffaele, additional, Gianesini, Raffaele, additional, Moorjani, Rajesh Gianchandani, additional, Deshpande, Rajkiran K, additional, Gorter, Ramon, additional, Ledesma, Raquel Leon, additional, Ruslan, Rategov, additional, Chhabra, Raunaq, additional, Talreja-Pelaez, Reena, additional, Suzuki, Rei, additional, Balestri, Riccardo, additional, Rosati, Riccardo, additional, Kiblawi, Rim, additional, Martins, Rita, additional, Angelico, Roberta, additional, Tutino, Roberta, additional, Persiani, Roberto, additional, Pollastri, Roberto, additional, López, Rocío González, additional, Perez, Rodrigo Oliva, additional, Hompes, Roel, additional, Lukanin, Roman, additional, Roser Termes Serra, R, additional, Brunaccino, Rossella, additional, Nakanishi, Ryota, additional, Stefan, Samuel, additional, Hernández, Sandra Paola Sánchez, additional, Di Carlo, Sara, additional, Ingallinella, Sara, additional, Domoto, Satoru, additional, Ikeda, Satoshi, additional, Mikalauskas, Saulius, additional, Kim, Seon Hahn, additional, Mantova, Serena, additional, Barbuta, Severius, additional, Li, Shaotang, additional, Yamaguchi, Shigeki, additional, Yamagishi, Shigeru, additional, Homma, Shigenori, additional, Tsujinaka, Shingo, additional, Yoshioka, Shinichi, additional, Mori, Shinichiro, additional, Tewari, Shirish, additional, Rayman, Shlomi, additional, Horiuchi, Sho, additional, Matoba, Shuichiro, additional, Morita, Shunji, additional, Yaman, Sibel, additional, Vigna, Silvia, additional, Testa, Silvio, additional, Ng, Simon, additional, Deidda, Simona, additional, Cicconi, Simone, additional, Di Maria, Simone, additional, Sibio, Simone, additional, Ersoz, Siyar, additional, Pejkova, Sofija, additional, Altarifi, Soliman, additional, He, Songbing, additional, Malakorn, Songphol, additional, Meindert, Sosef, additional, Sumikawa, Sosuke, additional, Parmar, Stavan, additional, Uranitsch, Stefan, additional, D'ugo, Stefano, additional, Giuliani, Stefano, additional, Breukink, Stéphanie, additional, Lee, Suk-Hwan, additional, Hata, Taishi, additional, Ishikawa, Takahisa, additional, Akiyoshi, Takashi, additional, Azuma, Takashi, additional, Kobatake, Takaya, additional, Fukuzaki, Takayuki, additional, Aiyama, Takeshi, additional, Yamada, Takeshi, additional, Garmanova, Tatiana, additional, Gómez-Sánchez, Tatiana, additional, Yamaguchi, Tatsuro, additional, Flores, Teresa De Jesús, additional, Usub, Teruyuki, additional, Tsuruma, Tetsuhiro, additional, Shimizu, Tetsuichiro, additional, Hristov, Tihomir Georgiev, additional, Van Loon, Ting, additional, Funakoshi, Tohru, additional, Manzia, Tommaso Maria, additional, Kiyomatsu, Tomomichi, additional, Katayama, Tomonari, additional, Kazuhito, Uemura, additional, Elmore, Ugo, additional, Grossi, Ugo, additional, Truchalev, Vadim A, additional, Rodríguez, Valentina Sosa, additional, Testa, Valentina, additional, Tonini, Valeria, additional, Celentano, Valerio, additional, Bettencourt, Vanessa, additional, Mammadov, Vasif, additional, Leyva, Verónica Alejandra Galue, additional, Mariscal, Veronica Georgina Ortega, additional, Seid, Victor Edmond, additional, Klemann, Victor, additional, Turrado-Rodriguez, Víctor, additional, Papagni, Vincenzo, additional, Vento, Vincenzo, additional, Frering, Vincent, additional, Vigorita, Vincenzo, additional, Petrove, Vitaliva V, additional, Lyadov, Vladimir, additional, Fu, Wei, additional, Mi, Wei, additional, Jeong, Woon Kyung, additional, Leclercq, Wouter K G, additional, De Sousa, Xavier, additional, Zhao, Xing, additional, Li, Xinxiang, additional, Wang, Xinxin, additional, Yang, Xuanhua, additional, Zhang, Xuelei, additional, Dong, Yan, additional, Erushevich, Yana, additional, Takii, Yasumasa, additional, Sumi, Yasuo, additional, Loli, Yeray Trujillo, additional, Yifat, Yosef Lishtzinsky, additional, Shimada, Yoshifumi, additional, Nabeya, Yoshihiro, additional, Ide, Yoshihito, additional, Wu, Yuan, additional, Tsukada, Yuichiro, additional, Miyamoto, Yuji, additional, Toiyama, Yuji, additional, Fujie, Yujiro, additional, Kaneko, Yuka, additional, Mokutani, Yukako, additional, Fujii, Yuki, additional, Kanemitsu, Yukihide, additional, Medkova, Yulia, additional, Chen, Yulong, additional, Ruiz, Yurema Gonzalez, additional, Kinugasa, Yusuke, additional, Sow, Zacaria, additional, Razzaq, Zeeshan, additional, Wang, Zejun, additional, Liu, Zheng, additional, Han, Zhenguo, additional, Tai, Zhihui, additional, Lai, Zhiyong, additional, Ng, Zi Qin, additional, and Dambrauskas, Zilvinas, additional
Published: 2020
Full Text: View/download PDF

31. Impact of asymptomatic COVID-19 patients in global surgical practice during the COVID-19 pandemic

Author: Bellato, V, primary, Konishi, T, additional, Pellino, G, additional, An, Y, additional, Piciocchi, A, additional, Sensi, B, additional, Siragusa, L, additional, Khanna, K, additional, Pirozzi, B M, additional, Franceschilli, M, additional, Campanelli, M, additional, Efetov, S, additional, Sica, G S, additional, Kefleyesus, A, additional, Hoofwijk, A G M, additional, Eldaly, Abdullah Sami, additional, Gonzalez, Abel, additional, Jawad, Adraoui, additional, Jooma, Ahmad, additional, Hafez, Ahmed Mousa, additional, Rubio, Ainhoa Valle, additional, Landaluce-Olavarria, Aitor, additional, Wu, Aiwen, additional, Nagatsu, Akihisa, additional, Inoue, Akira, additional, Kanamoto, Akira, additional, Ouchi, Akira, additional, El-Hussuna, Alaa, additional, Vazquez-Melero, Alba, additional, Wolthuis, Albert M, additional, Peral, Alberto M, additional, Lozano, Alejandra Cruz, additional, Efremov, Aleksandr, additional, Ryasantsev, Aleksandr V, additional, Di Giorgio, Alessandra, additional, Parente, Alessandro, additional, Tamburrini, Alessandro, additional, Alò, Alessio, additional, Forero-Torres, Alexander, additional, Vahrmeijer, Alexander L, additional, Varabei, Alexander, additional, Hinojosa, Siles, additional, Balkan, Ali Zeynel Abidin, additional, Frontali, Alice, additional, Oleg, Alikin, additional, Soler-Silva, Álvaro, additional, Makni, Amin, additional, André, Ana, additional, Cabrera, Ana María García, additional, Fernández, Ana María Gonzalez, additional, Minaya-Bravo, Ana M, additional, Rodríguez-Sánchez, Ana, additional, Musina, Ana-Maria, additional, Pangeni, Anang, additional, Zolotko, Anastasia, additional, Tonoyan, Andranik, additional, Balla, Andrea, additional, Belli, Andrea, additional, Cavallaro, Andrea, additional, Chierici, Andrea, additional, Divizia, Andrea, additional, Bucci, Andrea Fares, additional, Salido, Andrea Jiménez, additional, Morini, Andrea, additional, Muratore, Andrea, additional, Vignali, Andrea, additional, Chitul, Andrei, additional, Sebastian, Diaconescu Andrei, additional, Pcolkins, Andrejs, additional, Shchegolev, Andrey, additional, Hollenbeck, Andrew, additional, Wisneski, Andrew, additional, Iossa, Angelo, additional, D'Amore, Anna, additional, Hunter, Anndrew, additional, Hesketh, Anthony J, additional, La Brocca, Andrea, additional, Spinelli, Antonino, additional, Caires, Antonio, additional, D'Alessandro, Antonio, additional, Correo, Antonio Francisco Sanchís López, additional, Macrì, Antonio, additional, Navarro-Sánchez, Antonio, additional, Pronk, Apollo, additional, Akunc, Aram, additional, Mehri, Arash, additional, Pelta, Arie, additional, Papadopoulos, Aristeidis, additional, Kechagias, Aristotelis, additional, Rashid, Arshad, additional, Ramazanov, Artur, additional, Chandio, Ashfaq, additional, Kohyama, Atsushi, additional, Nishimura, Atsushi, additional, Ohkawa, Atsushi, additional, Dulskas, Audrius, additional, Jamal, Aun, additional, Mariani, Aurora, additional, Unal, Ayse Gizem, additional, Karagoz, Ayse, additional, Ozkan, Bahar Busra, additional, Salih, Barham, additional, Gülcü, Baris, additional, Pessia, Beatrice, additional, Martin-Perez, Beatriz, additional, Ielpo, Benedetto, additional, Tulelli, Berenice, additional, Yang, Bin, additional, Mhamed, Boumadani, additional, Murphy, Brenda, additional, Pirozzi, Brunella Maria, additional, Sensi, Bruno, additional, Langenhoff, Bs, additional, Belevi, Bulent, additional, Güney, Burak, additional, Ng, Caecilia, additional, Rueda, Camilo, additional, Roxburgh, Campbell S, additional, Feo, Carlo V, additional, Ferrari, Carlo, additional, Gazia, Carlo, additional, Pratesi, Carlo, additional, Ratto, Carlo, additional, Santacruz, Carlos Cerdán, additional, Arroyave, Carlos Rodolfo Martinez, additional, Macias, Carlos, additional, Fernandez, Carlota Garcia, additional, Fernandez, Carmen Cagigas, additional, Curtis-Martinez, Carolina, additional, Fortmann, Caroline, additional, Kim, Caroline, additional, Galeano, Catalina Uribe, additional, Barroso, Catarina, additional, Baldi, Caterina, additional, Foppa, Caterina, additional, Formisano, Cesare, additional, Li, Changzai, additional, Ding, Chao, additional, Wang, Chenyu, additional, Iacusso, Chiara, additional, Yang, Chongwei, additional, Pizzera, Christian, additional, Skias, Christoph, additional, Chouliras, Christos, additional, Liakos, Christos, additional, Matsuda, Chu, additional, Wu, Chun-yi, additional, Ozaslan, Cihangir, additional, Tanda, Cinzia, additional, Tommaso, Cipolat Mis, additional, Dagorno, Claire, additional, Ramos, Claudia Patricia Arellano, additional, Arcudi, Claudio, additional, Coco, Claudio, additional, Morales, Cleotilde Mateo, additional, Ali, Mujahid Zulfiqar, additional, Lozano, Coral Cózar, additional, Sala, Corrado, additional, Leo, Cosimo Alex, additional, Scarpa, Cosimo Riccardo, additional, Ferro, Cristian Varela, additional, Fernandez, Cristina Mosquera, additional, Morales-Garcia, D, additional, Nakano, Daisuke, additional, Cristian, Daniel, additional, Hechtl, Daniel, additional, Cánovas, Daniel Triguero, additional, Calabrese, Daniela, additional, Rega, Daniela, additional, Ferraro, Daniele, additional, Morezzi, Daniele, additional, Sommacale, Daniele, additional, Brogden, Danielle, additional, Miskovic, Danilo, additional, Merlini, David, additional, Pertile, Davide, additional, Coniglio, Denise, additional, Zhu, Dexiang, additional, Wu, Dianwen, additional, Coletta, Diego, additional, Rubio, Diego Ramos, additional, Sasia, Diego, additional, Fillipov, Dmitry, additional, Russiello, Domenico, additional, Dardanov, Dragomir, additional, Consten, E C J, additional, Smolskas, Edgaras, additional, Muttillo, Edoardo Maria, additional, Jones, Edward, additional, Sunami, Eiji, additional, Etienne, El-Helou, additional, Chalkiadaki, Elena, additional, Giacomelli, Elena, additional, Karbovnichaya, Elena, additional, Ruiz-Úcar, Elena, additional, Guaitoli, Eleonora, additional, Samadov, Elgun, additional, Jovine, Elio, additional, Treppiedi, Elio, additional, Vaterlini, Elisa Maria, additional, Zambaiti, Elisa, additional, Moggia, Elisabetta, additional, Coetzee, Elmi, additional, Chisari, Emanuele, additional, D'Errico, Emanuele, additional, Ciofic, Emilia, additional, Peña, Emilio, additional, Kurt, Emine, additional, Balık, Emre, additional, Gunay, Emre, additional, Sivrikoz, Emre, additional, Andolfi, Enrico, additional, Araimo, Enrico, additional, Lucci, Enrico, additional, Opocher, Enrico, additional, Pinotti, Enrico, additional, Rubino, Enrico, additional, Reyhan, Enver, additional, Mazzotta, Erica, additional, Navarro, Ernesto Barzola, additional, El-Helou, Etienne, additional, Licardie-Bolaños, Eugenio, additional, Porto, Eva Iglesias, additional, Contreras, Evelyn, additional, Boerma, Evert-Jan, additional, Cianchi, Fabio, additional, Marino, Fabio, additional, Uggeri, Fabio, additional, Han, Fanghai, additional, Calculli, Federica, additional, Falaschi, Federica, additional, Ghignone, Federico, additional, Perrone, Federico, additional, Borghi, Felice, additional, García, Felipe, additional, Agresta, Ferdinando, additional, Cananzi, Ferdinando Carlo Maria, additional, Mendoza-Moreno, Fernando, additional, Cengiz, Fevzi, additional, Almeida, Filipe Macedo, additional, Baracchi, Filippo, additional, Carannante, Filippo, additional, La Torre, Filippo, additional, Fernandes, Flavio, additional, Friedmacher, Florian, additional, Grama, Florin, additional, Carissimi, Francesca, additional, Pecchini, Francesca, additional, Bianco, Francesco, additional, Colombo, Francesco, additional, Ferrara, Francesco, additional, Litta, Francesco, additional, Carrano, Francesco Maria, additional, Martignoni, Francesco, additional, Tasselli, Francesco Menegon, additional, Milone, Francesco, additional, Pata, Francesco, additional, Sammartino, Francesco, additional, Zambianchi, Francesco, additional, Barragan, Francisco, additional, Herrero, Francisco, additional, Schlottmann, Francisco, additional, Den Boer, Frank C, additional, Pfeffer, Frank, additional, Fujita, Fumihiko, additional, Navarra, G, additional, Herrera-Almario, Gabriel, additional, Pozzo, Gabriele, additional, Capolupo, Gabriella Teresa, additional, Van Ramshorst, Gabrielle H, additional, Liscia, Gadiel, additional, Gallo, Gaetano, additional, Asawa, Ganesh, additional, Wang, Gaoxiang, additional, Raiyani, Gaurang, additional, Beets, Geerard, additional, Naval, Gemma Sugrañes, additional, Jin, Genfeng, additional, Chang, George J, additional, Saakian, George, additional, Kahane, Gerardo, additional, Borroni, Giacomo, additional, Lo Secco, Giacomo, additional, Baiocchi, Gian Luca, additional, Baronio, Gianluca, additional, Pagano, Gianluca, additional, Pattacini, Gianmaria Casoni, additional, Lisi, Giorgio, additional, Milito, Giovanni, additional, Sinibaldi, Giovanni, additional, Serrao, Giuditta, additional, Bagaglini, Giulia, additional, Sarro, Giuliano, additional, Brisinda, Giuseppe, additional, Candilio, Giuseppe, additional, Mangiameli, Giuseppe, additional, Giuliani, Giuseppe, additional, Martin-Martin, Gonzalo Pablo, additional, Bodzin, Gordon, additional, Leon, Graat, additional, Mackay, Graham, additional, Vasil, Granila, additional, Palmisano, Graziano, additional, Giovanna, Grella Maria, additional, Fernández, Guadalupe Campos, additional, Steingel, Guillermo Berrones, additional, Zhang, Guoyun, additional, Choi, Gyu Seog, additional, Chen, Haipeng, additional, Hirose, Hajime, additional, Kayano, Hajime, additional, Ulgur, Hanife Seyda, additional, Impellizzeri, Harmony, additional, Ariola, Hasani, additional, Liu, Heli, additional, Medina, Heriberto, additional, Miyauchi, Hideaki, additional, Takahashi, Hidekazu, additional, Hayashi, Hideki, additional, Ishikawa, Hideki, additional, Ishida, Hideyuki, additional, De Vries, Hilbert, additional, Ulman, Hilmican, additional, Kon, Hirofumi, additional, Ota, Hirofumi, additional, Akamatsu, Hiroki, additional, Tamagawa, Hiroshi, additional, Shoji, Hirotaka, additional, Egi, Hiroyuki, additional, Matsubara, Hisahiro, additional, Miki, Hisanori, additional, Elfeki, Hossam, additional, Lin, Hung-Hsin, additional, Giani, Iacopo, additional, Caravaca-García, Iban, additional, Takemasa, Ichiro, additional, Angriman, Imerio, additional, Negoi, Ionut, additional, Volkova, Irina, additional, Russo, Iris, additional, Kronberger, Irmgard E, additional, Shageev, Iskander, additional, Aydin, Ishak, additional, Mora Guzmán, Ismael, additional, Novak, Ivana, additional, Giuliano, Izzo, additional, Rachmuth, Jacob, additional, Ngu, James Chi-Yong, additional, Glasbey, James, additional, Stoot, Jan, additional, Žatecky, Jan, additional, Melenhorst, Jarno, additional, Van Der Wal, J B C, additional, Leijtens, Jeroen, additional, Bogach, Jessica, additional, Elliott, Jessie, additional, De Wilt, J H W, additional, Han, Jiagang, additional, Cui, Jian, additional, Liu, Jiaqi, additional, Khan, Jim, additional, Wirawan, Jimmy Panji, additional, Zhang, Jinji, additional, Manyari, Joel Davis Osorio, additional, Doerner, Johannes, additional, Bock, Jonathan, additional, Konsten, Joop, additional, Castro, Jorge Mario, additional, Grobas, Jorge Pérez, additional, Pereira, José, additional, Juloski, Jovan, additional, Laina, Juan Luis Blas, additional, Solórzano, Juan José, additional, López, Juan Ramón Gómez, additional, Li, Jun, additional, Watanabe, Jun, additional, Kwak, Jung-Myun, additional, Hasegawa, Junichi, additional, Hiro, Junichiro, additional, Sergey, K, additional, Zhang, Kai, additional, Nagahori, Kaoru, additional, Martinez, Karla, additional, Tokuhara, Katsuji, additional, Danno, Katsuki, additional, Uehara, Kay, additional, Yoshimatsu, Kazuhiko, additional, Ehara, Kazuhisa, additional, Ueda, Kazuki, additional, Suda, Kazuyoshi, additional, Yamamoto, Kazuyuki, additional, Ishimaru, Kei, additional, Kimura, Kei, additional, Hirata, Keiji, additional, Deen, Kemal, additional, Imaizumi, Ken, additional, Yamada, Jenji, additional, Tanakura, Kenta, additional, Rida, Khaled, additional, Sugimoto, Kiichi, additional, Kotaro, Kitani, additional, Shi, Kiwisure, additional, Okabayashi, Koji, additional, Hida, Koya, additional, Kataoka, Kozo, additional, Hongo, Kumiko, additional, Xia, Kunkun, additional, Tseng, Larissa, additional, Reime, Lars, additional, Lorenzon, Laura, additional, Ruano, Laura Muiños, additional, Siragusa, Leandro, additional, Zhou, Lei, additional, De Nes, Lindsey, additional, Brandariz, Lorena, additional, Morini, Lorenzo, additional, Petagna, Lorenzo, additional, Ripamonti, Lorenzo, additional, Martinez, Lourdes Hernandez, additional, Pio, Luca, additional, Sacco, Luca, additional, Carvalho, Lucia, additional, Zorcolo, Luigi, additional, Pérez-Sánchez, Luis Eduardo, additional, Esparza, Luis Humberto Reyes, additional, Aguilar, Luis Tallon, additional, Garner, Madeleine, additional, Sugimoto, Maki, additional, Nagashima, Makoto, additional, Shiozawa, Manabu, additional, Simone, Manfredelli, additional, Ferrer-Marquez, Manuel, additional, Carvalho, Marcia, additional, Alifano, Marco, additional, Arganini, Marco, additional, Calussi, Marco, additional, Catarci, Marco, additional, Allaix, Marco Ettore, additional, Forlin, Marco, additional, Milone, Marco, additional, Paci, Marco, additional, Franceschilli, Marzia, additional, Fodor, Margot, additional, Antipova, Maria, additional, Martos, Maria Beltran, additional, Giuffrida, Maria Carmela, additional, Tabernilla, María Diez, additional, Quirós, María José Alcaide, additional, Lemma, Maria, additional, Correo, Maria Luisa Reyes Diaz, additional, Małowiecka, Maria, additional, Bellomo, Maria Paola, additional, Fernandez, Maria Ramos, additional, Socias, María, additional, Rizk, Mariam, additional, Aurora, Mariani, additional, Antolinez, Mariano Alvarez, additional, Ninkovic, Marijana, additional, Giuffrida, Mario, additional, De Roos, Marnix A J, additional, Lara, Marta Cañón, additional, Agustin, Marta Climent, additional, Cuadrado, Marta, additional, Pascual, Marta, additional, Lemmerer, Martina, additional, Carlos, R, additional, Okamoto, Masa, additional, Miyo, Masaaki, additional, Inomata, Masafumi, additional, Ikenaga, Masakazu, additional, Tsujie, Masaki, additional, Yasuno, Masamichi, additional, Kotake, Masanori, additional, Sato, Masanori, additional, Yasui, Masayoshi, additional, Lavazza, Matteo, additional, Rottoli, Matteo, additional, Zuin, Matteo, additional, Zuluaga, Mauricio, additional, Cervellera, Maurizio, additional, Cesari, Maurizio, additional, Zizzo, Maurizio, additional, Garino, Mauro, additional, Ghirardi, Mauro, additional, Montuori, Mauro, additional, Podda, Mauro, additional, Santarelli, Mauro, additional, Koc, Mehmet Ali, additional, Baini, Melissa, additional, Campanelli, Michela, additional, Manigrasso, Michele, additional, Zuolo, Michele, additional, Cunha, Miguel F, additional, Misca, Mihaela, additional, Slavchev, Mihail, additional, Danilov, Mikhail, additional, Shigaev, Mikhail, additional, Martens, Milou, additional, Kobayashi, Minako, additional, Ren, Mingyang, additional, Ishizuka, Mitsuru, additional, Hassan, Mohammed Mustafa, additional, Siblini, Mohamad, additional, Sahloul, Mohamed, additional, Keramati, Mohammad Reza, additional, Karunakaran, Monish, additional, Markel, Moritz, additional, Majeed, Mudassar, additional, Younis, Muhammad Umar, additional, Akin, Muhammed Ikbal, additional, Laraibe, Munazza, additional, Derebey, Murat, additional, Kendirci, Murat, additional, Fukunaga, Mutsumi, additional, Matsubara, Nagahide, additional, Ordaz, Narce Eunice Cruz, additional, Samalavicius, Narimantas Evaldas, additional, Keeratibharat, Nattawut, additional, Angelis, Nicola, additional, Gica, Nicolae, additional, Mariani, Nicoló Maria, additional, Ramino, Nicolò, additional, Falco, Nicolò, additional, Smart, Neil, additional, De Korte, Niels, additional, Kok, Niels F M, additional, Jamieson, Nigel B, additional, Aberyasev, Nikolay, additional, Bruklich, Nikolay, additional, Ichikawa, Nobuki, additional, Miyoshi, Norikatsu, additional, De Palma, Norma, additional, Figueiredo, Nuno, additional, Torrecilla, Nuria Ortega, additional, Dybov, Oleg G, additional, Yudin, Oleg, additional, Crepin, Ollende, additional, Gomez, Oscar, additional, Sert, Ozlem Zeliha, additional, Lominchar, Pablo Lozano, additional, Menéndez, Pablo, additional, De Nardi, Paola, additional, Tejedor, Patricia, additional, Jordan, Patrick, additional, Tan, Patrick, additional, Marsanic, Patrizia, additional, Natalya, Pechnikova, additional, Baños, Pedro Parra, additional, Rebasa, Pere, additional, Neary, Peter M, additional, Tanis, Pieter, additional, Giustacchini, Piero, additional, Anoldo, Pietro, additional, Concejo, Pilar, additional, Cao, Pin, additional, Chandrasinghe, Pramodh, additional, Abeyratne, Prasad, additional, Wang, Quan, additional, Klicks, R J, additional, Riquelme, Rafael Ferrer, additional, De Luca, Raffaele, additional, Galli, Raffaele, additional, Gianesini, Raffaele, additional, Moorjani, Rajesh Gianchandani, additional, Deshpande, Rajkiran K, additional, Gorter, Ramon, additional, Ledesma, Raquel Leon, additional, Ruslan, Rategov, additional, Chhabra, Raunaq, additional, Talreja-Pelaez, Reena, additional, Suzuki, Rei, additional, Balestri, Riccardo, additional, Rosati, Riccardo, additional, Kiblawi, Rim, additional, Martins, Rita, additional, Angelico, Roberta, additional, Tutino, Roberta, additional, Persiani, Roberto, additional, Pollastri, Roberto, additional, López, Rocío González, additional, Perez, Rodrigo Oliva, additional, Hompes, Roel, additional, Lukanin, Roman, additional, Roser Termes Serra, R, additional, Brunaccino, Rossella, additional, Nakanishi, Ryota, additional, Stefan, Samuel, additional, Hernández, Sandra Paola Sánchez, additional, Di Carlo, Sara, additional, Ingallinella, Sara, additional, Domoto, Satoru, additional, Ikeda, Satoshi, additional, Mikalauskas, Saulius, additional, Kim, Seon Hahn, additional, Mantova, Serena, additional, Barbuta, Severius, additional, Li, Shaotang, additional, Yamaguchi, Shigeki, additional, Yamagishi, Shigeru, additional, Homma, Shigenori, additional, Tsujinaka, Shingo, additional, Yoshioka, Shinichi, additional, Mori, Shinichiro, additional, Tewari, Shirish, additional, Rayman, Shlomi, additional, Horiuchi, Sho, additional, Matoba, Shuichiro, additional, Morita, Shunji, additional, Yaman, Sibel, additional, Vigna, Silvia, additional, Testa, Silvio, additional, Ng, Simon, additional, Deidda, Simona, additional, Cicconi, Simone, additional, Di Maria, Simone, additional, Sibio, Simone, additional, Ersoz, Siyar, additional, Pejkova, Sofija, additional, Altarifi, Soliman, additional, He, Songbing, additional, Malakorn, Songphol, additional, Meindert, Sosef, additional, Sumikawa, Sosuke, additional, Parmar, Stavan, additional, Uranitsch, Stefan, additional, D'ugo, Stefano, additional, Giuliani, Stefano, additional, Breukink, Stéphanie, additional, Lee, Suk-Hwan, additional, Hata, Taishi, additional, Ishikawa, Takahisa, additional, Akiyoshi, Takashi, additional, Azuma, Takashi, additional, Kobatake, Takaya, additional, Fukuzaki, Takayuki, additional, Aiyama, Takeshi, additional, Yamada, Takeshi, additional, Garmanova, Tatiana, additional, Gómez-Sánchez, Tatiana, additional, Yamaguchi, Tatsuro, additional, Flores, Teresa De Jesús, additional, Usub, Teruyuki, additional, Tsuruma, Tetsuhiro, additional, Shimizu, Tetsuichiro, additional, Hristov, Tihomir Georgiev, additional, Van Loon, Ting, additional, Funakoshi, Tohru, additional, Manzia, Tommaso Maria, additional, Kiyomatsu, Tomomichi, additional, Katayama, Tomonari, additional, Kazuhito, Uemura, additional, Elmore, Ugo, additional, Grossi, Ugo, additional, Truchalev, Vadim A, additional, Rodríguez, Valentina Sosa, additional, Testa, Valentina, additional, Tonini, Valeria, additional, Celentano, Valerio, additional, Bettencourt, Vanessa, additional, Mammadov, Vasif, additional, Leyva, Verónica Alejandra Galue, additional, Mariscal, Veronica Georgina Ortega, additional, Seid, Victor Edmond, additional, Klemann, Victor, additional, Turrado-Rodriguez, Víctor, additional, Papagni, Vincenzo, additional, Vento, Vincenzo, additional, Frering, Vincent, additional, Vigorita, Vincenzo, additional, Petrove, Vitaliva V, additional, Lyadov, Vladimir, additional, Fu, Wei, additional, Mi, Wei, additional, Jeong, Woon Kyung, additional, Leclercq, Wouter K G, additional, De Sousa, Xavier, additional, Zhao, Xing, additional, Li, Xinxiang, additional, Wang, Xinxin, additional, Yang, Xuanhua, additional, Zhang, Xuelei, additional, Dong, Yan, additional, Erushevich, Yana, additional, Takii, Yasumasa, additional, Sumi, Yasuo, additional, Loli, Yeray Trujillo, additional, Yifat, Yosef Lishtzinsky, additional, Shimada, Yoshifumi, additional, Nabeya, Yoshihiro, additional, Ide, Yoshihito, additional, Wu, Yuan, additional, Tsukada, Yuichiro, additional, Miyamoto, Yuji, additional, Toiyama, Yuji, additional, Fujie, Yujiro, additional, Kaneko, Yuka, additional, Mokutani, Yukako, additional, Fujii, Yuki, additional, Kanemitsu, Yukihide, additional, Medkova, Yulia, additional, Chen, Yulong, additional, Ruiz, Yurema Gonzalez, additional, Kinugasa, Yusuke, additional, Sow, Zacaria, additional, Razzaq, Zeeshan, additional, Wang, Zejun, additional, Liu, Zheng, additional, Han, Zhenguo, additional, Tai, Zhihui, additional, Lai, Zhiyong, additional, Ng, Zi Qin, additional, and Dambrauskas, Zilvinas, additional
Published: 2020
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32. DTA0100, dual topoisomerase II and microtubule inhibitor, evades paclitaxel resistance in P-glycoprotein overexpressing cancer cells

Author: Miguel X. Fernandes, Jelena Dinić, Jasna Bankovic, Natasa Kovacevic-Grujicic, José M. Padrón, Carla Ríos-Luci, Víctor S. Martín, Nuria Ortega, Ana Podolski-Renić, and Milica Pešić
Subjects: 0301 basic medicine, Paclitaxel, Pharmaceutical Science, Apoptosis, P-glycoprotein, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Tubulin, Microtubule, Cell Line, Tumor, Neoplasms, medicine, Humans, Topoisomerase II Inhibitors, Colchicine, ATP Binding Cassette Transporter, Subfamily B, Member 1, Microtubule nucleation, biology, Topoisomerase, Cell Cycle Checkpoints, Antineoplastic Agents, Phytogenic, Molecular biology, Tubulin Modulators, 3. Good health, Vinblastine, Multi-drug resistance, Microtubule targeting agents, 030104 developmental biology, Acrylates, chemistry, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, biology.protein, β-tubulin, Caprylates, medicine.drug
Abstract: The efficacy of microtubule targeting agents in cancer treatment has been compromised by the development of drug resistance that may involve both, P-glycoprotein overexpression and the changes in β-tubulin isoforms' expression. The anti-Topoisomerase II activity of methyl 4-((E)-2-(methoxycarbonyl)vinyloxy)oct-2-ynoate (DTA0100) was recently reported. Herein, we further evaluated this propargylic enol ether derivative and found that it exerts inhibitory effect on tubulin polymerization by binding to colchicine binding site. DTA0100 mitotic arrest properties were investigated in two multi-drug resistant cancer cell lines with P-glycoprotein overexpression (colorectal carcinoma and glioblastoma). The sensitivity of multi-drug resistant cancer cell lines to DTA0100 was not significantly changed in contrast to microtubule targeting agents such as paclitaxel, vinblastine and colchicine. DTA0100 clearly induced microtubule depolymerization, leading to disturbance of cell cycle kinetics and subsequent apoptosis. The fine-tuning in β-tubulin isoforms expression observed in multi-drug resistant cancer cells may influence the efficacy of DTA0100. Importantly, DTA0100 blocked the P-glycoprotein function in both multi-drug resistant cancer cell lines without inducing the increase in P-glycoprotein expression. Therefore, DTA0100 acting as dual inhibitor of Topoisomerase II and microtubule formation could be considered as multi-potent anticancer agent. Besides, it is able to overcome the problem of drug resistance that emerges in the therapeutic approaches with either Topoisomerase II or microtubule targeting agents. This is the peer reviewed version of the following article: Podolski-Renić A, Banković J, Dinić J, Ríos-Luci C, Fernandes MX, Ortega N, Kovačević-Grujičić N, Martín VS, Padrón JM, Pešić M. DTA0100, dual topoisomerase II and microtubule inhibitor, evades paclitaxel resistance in P-glycoprotein overexpressing cancer cells. Eur. J. Pharm. Sci. 2017;105:159-168. [http://dx.doi.org/10.1016/j.ejps.2017.05.011] Related to: [https://ibiss-r.rcub.bg.ac.rs/handle/123456789/2762]
Published: 2017

33. A Cyclometalated Ruthenium-NHC Precatalyst for the Asymmetric Hydrogenation of (Hetero)arenes and Its Activation Pathway

Author: Nuria Ortega, Robert Wolf, Slawomir Kock, Danny Schlüns, Markus Plois, Bernhard Beiring, Daniel Paul, Johannes Neugebauer, and Frank Glorius
Subjects: Activation pathway, 010405 organic chemistry, Stereochemistry, Ligand, Organic Chemistry, Asymmetric hydrogenation, chemistry.chemical_element, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Ruthenium, Catalysis, Inorganic Chemistry, chemistry.chemical_compound, Deprotonation, chemistry, Reactivity (chemistry), Physical and Theoretical Chemistry, Carbene
Abstract: This study describes the structural investigation of a highly versatile ruthenium-NHC (N-heterocyclic carbene) catalyst complex, which has been established for the asymmetric hydrogenation of various aromatic compounds. A complex containing an unusual doubly deprotonated NHC ligand was isolated and identified as the precatalyst to this complex. When its subsequent reactivity was monitored, two additional precatalysts, featuring partially hydrogenated naphthyl substituents, were characterized spectroscopically. Ligand hydrogenation appears to be a key activation process en route to the active catalyst.
Published: 2016

34. Life-threating upper gastrointestinal bleeding due to a primary aorto-jejunal fistula

Author: Miriam Boqué, Juan Echeverri, Anna Gené, José María Balibrea, Nivardo Rodriguez, Manel Armengol, Elena Fernández de Sevilla, Silvia Valverde, and Nuria Ortega
Subjects: medicine.medical_specialty, Fistula, Aorto-enteric fistula, PTFE, polytetrafluoroethylene, Case Report, Ileum, Computed tomography, Abdominal aneurysm, EGD, esophagogastroduodenoscopy, Esophagogastroduodenoscopy, digestive system, Jejunum, Medicine, AEF, aorto-enteric fistula, Upper gastrointestinal bleeding, Jejunal fistula, medicine.diagnostic_test, business.industry, digestive, oral, and skin physiology, medicine.disease, CT, computed tomography, Surgery, medicine.anatomical_structure, cardiovascular system, business
Abstract: Highlights • Primary aorto-enteric fistula is an uncommon life-threating condition. • Primary aorto-enteric fistula is usually caused by an untreated abdominal aortic aneurysm. • The treatment of choice for aorto-enteric fistula is emergent surgery. • High clinical suspicion is essential to make a correct diagnosis of aorto-enteric fistula., Introduction Primary aorto-enteric fistula (AEF) is an uncommon life-threating condition. Only 4% of them involve the jejunum or ileum and its mortality ranges from 33 to 85%. Presentation of case A 54-year-old female was admitted to the Emergency Department with syncope and hematemesis. The esophagogastroduodenoscopy found a pulsatile vessel in the second portion of the duodenum. A computed tomography scan showed an AEF with an infrarenal aortic aneurysm and iliac artery thrombosis. During surgery, an infrarenal aortic aneurysm complicated with an aorto-jejunal fistula was found. An axilo-bifemoral bypass, open repair of the aneurysm and segmental small bowel resection with primary suture of the jejunal defect were performed. Discussion Depending on previous aortic grafting, AEF can be classified as primary or secondary. Primary AEF is usually caused by an untreated abdominal aortic aneurysm, commonly presenting an infectious etiology. The main clinical sign is a “herald” hemorrhage. The EGD is considered as the first step in diagnosing AEF. The treatment of choice for AEF is emergent surgery. Use of broad-spectrum antibiotics is mandatory in the postoperative period to avoid fistula recurrence. Conclusion AEF is a rare entity with a high mortality. High clinical suspicion is essential to make a correct diagnosis, which is crucial for the prognosis of these patients, such is the case of our patient. If hemodynamic stability is achieved, it allows to employ surgical strategies in which extra-abdominal bypass is performed before fistula is treated.
Published: 2015

35. Asymmetrische Hydrierung disubstituierter Furane

Author: Frank Glorius, Nuria Ortega, and Jędrzej Wysocki
Subjects: General Medicine
Abstract: Eine enantioselektive Hydrierung disubstituierter Furane in Gegenwart eines chiralen Rutheniumkatalysators mit N-heterocyclischem Carbenliganden uberfuhrt Furane in wertvolle enantiomerenangereicherte, disubstituierte Tetrahydrofurane.
Published: 2014

36. Ruthenium-NHC-katalysierte asymmetrische Hydrierung von Indolizinen: Zugang zu Indolizidin-Alkaloiden

Author: Dan-Tam D. Tang, Frank Glorius, Dongbing Zhao, Slawomir Urban, and Nuria Ortega
Subjects: Chemistry, General Medicine
Published: 2013

37. N-Formylation of Amines by Methanol Activation

Author: Nuria Ortega, Frank Glorius, and Christian Richter
Subjects: Primary (chemistry), Chemistry, Organic Chemistry, Biochemistry, Catalysis, Formylation, chemistry.chemical_compound, Homogeneous, Organic chemistry, Dehydrogenation, Methanol, Physical and Theoretical Chemistry, Formamides, Carbene
Abstract: The homogeneous catalyzed dehydrogenation of methanol in a synthetically valuable cross-coupling reaction was achieved. By the use of a simple ruthenium-N-heterocyclic carbene complex, MeOH and primary or secondary amines can be converted into formamides.
Published: 2013

38. Highly asymmetric synthesis of (+)-corsifuran A. Elucidation of the electronic requirements in the Ruthenium–NHC catalyzed hydrogenation of benzofurans

Author: Bernhard Beiring, Slawomir Urban, Frank Glorius, and Nuria Ortega
Subjects: Reaction conditions, 010405 organic chemistry, Organic Chemistry, Asymmetric hydrogenation, Enantioselective synthesis, Noyori asymmetric hydrogenation, chemistry.chemical_element, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Catalysis, Ruthenium, chemistry.chemical_compound, chemistry, Drug Discovery, Organic chemistry, Benzofuran
Abstract: A short and efficient synthesis of ent-corsifuran A by a highly asymmetric hydrogenation of a benzofuran precursor is reported. In addition, the electronic influence of the substituents on the asymmetric hydrogenation of benzofurans is provided. Whereas the hydrogenation of electron-deficient benzofurans was achieved under very mild conditions, the presence of electron-donating groups in the benzofuran required harsher reaction conditions for achieving full conversion to the 2,3-dihydrobenzofuran.
Published: 2012

39. Ruthenium-NHC-katalysierte hoch asymmetrische Hydrierung von Benzofuranen

Author: Nuria Ortega, Bernhard Beiring, Frank Glorius, and Slawomir Urban
Subjects: Chemistry, General Medicine
Published: 2012

40. Lead Generation: Methods and Strategies, Volume 68. Edited by Jörg Holenz. Raimund Mannhold, Hugo Kubinyi and Gerd Folkers (Series Editors)

Author: Robert Webster and Nuria Ortega Hernandez
Subjects: Pharmacology, Psychoanalysis, Philosophy, Organic Chemistry, Drug Discovery, Molecular Medicine, Environmental ethics, General Pharmacology, Toxicology and Pharmaceutics, Biochemistry, Volume (compression)
Published: 2017

41. Ligandengesteuerte hoch regioselektive und asymmetrische Hydrierung von Chinoxalinen, katalysiert durch Ruthenium-Komplexe von N-heterocyclischen Carbenen

Author: Nuria Ortega, Slawomir Urban, and Frank Glorius
Subjects: Chemistry, General Medicine
Published: 2011

42. Research Journals on Design: I+D Diseño and the definition of a Latin model

Author: Nuria Ortega and Sebastián Garrido
Subjects: General Arts and Humanities, Modeling and Simulation, General Engineering
Published: 2010

43. Estabilidad de las concentraciones de factor de crecimiento similar a la insulina tipo 1, gastrina y androstendiona en suero

Author: Yolanda Alba Macias, María Luisa Granada Ybern, Jaume Barallat Martínez de Osaba, Nuria Ortega Castillo, Cristian Morales Indiano, and María Doladé Botias
Subjects: Biochemistry (medical), Clinical Biochemistry
Abstract: Resumen Objetivo Evaluar y comparar la estabilidad de las concentraciones de IGF-1 ( insulin-like growth factor ‘factor de crecimiento similar a la insulina, tipo 1’), gastrina y androstendiona en 2 tipos de suero: uno alicuotado en un tubo secundario tras una centrifugacion y otro directamente en un tubo primario con gel separador. Material y metodos Las muestras de sangre se obtuvieron de 11 voluntarios sanos (8 mujeres, 3 varones). Los tubos se centrifugaron durante 20 min y se almacenaron a 4–8 °C. Las muestras se procesaron en el analizador Immulite 2000 Siemens en 8 tiempos, comprendidos entre los 90 min y los 10 dias. Los limites de estabilidad se establecieron por medio de la utilizacion de las directrices de la Sociedad Espanola de Quimica Clinica (SEQC) sobre muestras biologicas. Resultados Las concentraciones de IGF-1 y androstendiona permanecieron estables en los 2 tipos de suero durante los 10 dias estudiados. La gastrina mostro un descenso progresivo en los valores obtenidos. Permanecio estable solamente 8 h en el suero alicuotado y 48 h en el tubo primario. En ningun parametro se observaron diferencias en las concentraciones basales obtenidas entre los 2 tipos de muestra. Conclusiones La conservacion de muestras tanto en suero alicuotado como en tubo primario con gel separador a 4 °C es adecuada para el IGF-1 y la androstendiona hasta los 10 dias. La gastrina es estable hasta 8 h en suero alicuotado y hasta 48 h en tubo primario con gel separador. Los tubos primarios con gel separador parecen adecuados para la conservacion habitual de las 3 determinaciones.
Published: 2009

44. Lead Generation: Methods and Strategies, Volume 68. Edited by Jörg Holenz. Raimund Mannhold, Hugo Kubinyi and Gerd Folkers (Series Editors)

Author: Webster, Robert, primary and Hernandez, Nuria Ortega, additional
Published: 2017
Full Text: View/download PDF

45. Fluorescence Resonance Energy Transfer (FRET) and Proximity Ligation Assays Reveal Functionally Relevant Homo- and Heteromeric Complexes among Hyaluronan Synthases HAS1, HAS2, and HAS3*

Author: Nuria Ortega Vico, Antti Hassinen, Raija Tammi, Paraskevi Heldin, Ashik Jawahar Deen, Aino Ruusala, Genevieve Bart, Sakari Kellokumpu, Marukku I. Tammi, François M. Pujol, and Anthony Squire
Subjects: endocrine system, Medizin, Glycobiology and Extracellular Matrices, Proximity ligation assay, Biology, Hyaluronan Synthase 2, Biochemistry, chemistry.chemical_compound, Mice, Hyaluronic acid, Chlorocebus aethiops, Fluorescence Resonance Energy Transfer, Homomeric, Animals, Humans, Binding site, Glucuronosyltransferase, Hyaluronic Acid, Protein Structure, Quaternary, Molecular Biology, HAS1, Cell Biology, Peptide Fragments, Protein Structure, Tertiary, Isoenzymes, Hyaluronan synthase, Förster resonance energy transfer, chemistry, COS Cells, biology.protein, Protein Multimerization, Hyaluronan Synthases
Abstract: In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space. It has been shown that HAS2 immunoprecipitates contain functional HAS2 homomers and also heteromers with HAS3 (Karousou, E., Kamiryo, M., Skandalis, S. S., Ruusala, A., Asteriou, T., Passi, A., Yamashita, H., Hellman, U., Heldin, C. H., and Heldin, P. (2010) The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination. J. Biol. Chem. 285, 23647-23654). Here we have systematically screened in live cells, potential interactions among the HAS isoenzymes using fluorescence resonance energy transfer (FRET) and flow cytometric quantification. We show that all HAS isoenzymes form homomeric and also heteromeric complexes with each other. The same complexes were detected both in Golgi apparatus and plasma membrane by using FRET microscopy and the acceptor photobleaching method. Proximity ligation assays with HAS antibodies confirmed the presence of HAS1-HAS2, HAS2-HAS2, and HAS2-HAS3 complexes between endogenously expressed HASs. C-terminal deletions revealed that the enzymes interact mainly via uncharacterized N-terminal 86-amino acid domain(s), but additional binding site(s) probably exist in their C-terminal parts. Of all the homomeric complexes HAS1 had the lowest and HAS3 the highest synthetic activity. Interestingly, HAS1 transfection reduced the synthesis of hyaluronan obtained by HAS2 and HAS3, suggesting functional cooperation between the isoenzymes. These data indicate a general tendency of HAS isoenzymes to form both homomeric and heteromeric complexes with potentially important functional consequences on hyaluronan synthesis.
Published: 2015

46. ChemInform Abstract: Asymmetric Hydrogenation of Disubstituted Furans

Author: Nuria Ortega, Frank Glorius, and Jędrzej Wysocki
Subjects: chemistry.chemical_compound, chemistry, Stereochemistry, Furan, Asymmetric hydrogenation, General Medicine, Sequence (medicine)
Abstract: Both 2,5- and 2,4-disubstituted furan substrates can be hydrogenated successfully in the presence of a chiral Ru-complex following the 3-step sequence shown.
Published: 2015

47. ¿La percepción de competencia y alfabetización motriz median la relación entre la competencia motriz y la práctica de actividad física?

Author: Benavent, Nuria Ortega, Menescardi, Cristina, Oyarzún, Jaime Cárcamo, and Estevan, Isaac
Abstract: La percepción de competencia (PCM) y alfabetización motriz (PAM), junto con la competencia motriz real (CMR) son factores relevantes en el mantenimiento de estilos de vida activos en adolescentes. El objetivo principal de este estudio ha sido analizar el rol mediador de la PCM y PAM en la relación entre la CMR y la actividad física (AF). En este estudio han participado voluntariamente 222 estudiantes (112 chicas; 50.5%) de 12 a 14 años. Mediante la realización de modelos de ecuaciones estructurales, se ha analizado la relación entre la CMR y la AF y la influencia mediadora de la PCM y la PAM en dicha relación. El primer modelo considerando la PCM (CFI = .97; RMSEA = .08; SRMR = .04) y el segundo modelo con la PAM (CFI = .99; RMSEA = .05; SRMR = .03) muestran un ajuste satisfactorio. Por ello, no sólo es importante fomentar la CMR, sino que se han de desarrollar factores psicosociales y emocionales como la PCM y la PAM para promover la práctica de AF entre adolescentes.
Published: 2024
Full Text: View/download PDF

48. ChemInform Abstract: β-Hydroxy-γ-lactones as Nucleophiles in the Nicholas Reaction for the Synthesis of Oxepene Rings. Enantioselective Formal Synthesis of (-)-Isolaurepinnacin (I) and (+)-Rogioloxepane A (II)

Author: Julio Rodríguez-López, Tomás Martín, Víctor S. Martín, and Nuria Ortega
Subjects: Formal synthesis, Ring-closing metathesis, Nucleophile, Stereochemistry, Chemistry, Intermolecular force, Enantioselective synthesis, Nicholas reaction, General Medicine, Isolaurepinnacin
Abstract: The key steps consist of an intermolecular Nicholas reaction with a β-hydroxy-γ-lactone as a nucleophile and a ring closing metathesis reaction.
Published: 2014

49. ChemInform Abstract: Ruthenium-NHC-Catalyzed Asymmetric Hydrogenation of Indolizines: Access to Indolizidine Alkaloids

Author: Dan-Tam D. Tang, Nuria Ortega, Dongbing Zhao, Frank Glorius, and Slawomir Urban
Subjects: Indolizidines, Melanophryniscus stelzneri, biology, Stereochemistry, fungi, Asymmetric hydrogenation, food and beverages, Indolizidine, General Medicine, biology.organism_classification, chemistry.chemical_compound, Swainsonine, Castanospermine, chemistry, Glycoside hydrolase, Monomorium
Abstract: Indolizidine alkaloids constitute a very important class of natural products. These metabolites derived from lysine can be isolated from diverse sources, like fungi, bacteria, higher plants, invertebrates, and vertebrates. Their core structure is characterized by fused sixand five-membered rings, with a bridgehead nitrogen atom, and is found in 25–30% of all naturally occurring alkaloids. The most important types of indolizidines are plant-derived polyhydroxylated indolizidines, like swainsonine and castanospermine, which are glycosidase inhibitors with activity against HIV, as well as alkylindolizidines, like monomorine (3), which is isolated from ants (Monomorium pharaonis) and from the skin of amphibians (Melanophryniscus stelzneri), and is believed to serve in their defense against predators (Scheme 1).
Published: 2014

50. β-Hydroxy-γ-lactones as nucleophiles in the Nicholas reaction for the synthesis of oxepene rings. Enantioselective formal synthesis of (-)-isolaurepinnacin and (+)-rogioloxepane A

Author: Víctor S. Martín, Nuria Ortega, Julio Rodríguez-López, Tomás Martín, Ministerio de Economía y Competitividad (España), and European Commission
Subjects: Olefin fiber, 010405 organic chemistry, Chemistry, Stereochemistry, Intermolecular force, Metals and Alloys, Enantioselective synthesis, Nicholas reaction, Stereoisomerism, General Chemistry, 010402 general chemistry, Metathesis, 01 natural sciences, Isolaurepinnacin, Catalysis, 3. Good health, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Lactones, Formal synthesis, Nucleophile, Oxepins, Materials Chemistry, Ceramics and Composites
Abstract: The enantioselective formal synthesis of (-)-isolaurepinnacin and (+)-rogioloxepane A has been achieved. The key steps are an intermolecular Nicholas reaction with a β-hydroxy-γ-lactone as the nucleophile, to form branched linear ethers, and an olefin ring-closing metathesis to obtain the oxepene core. This journal is © the Partner Organisations 2014., We thank the Spanish MINECO, cofinanced by the European Regional Development Fund (ERDF) (CTQ2011-28417-C02-01 and CTQ2011-22653) and the IMBRAIN project (FP7-REGPOT-2012-CT2012-31637-IMBRAIN), funded under the 7th Framework Programme (CAPACITIES) for financial support.
Published: 2014

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