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283 results on '"Nurchi, A M"'

19. Multipurpose Iron-Chelating Ligands Inspired by Bioavailable Molecules.

Author

Cini, Elena, Crisponi, Guido, Fantasia, Alessandra, Cappai, Rosita, Siciliano, Sofia, Florio, Giuseppe Di, Nurchi, Valeria M., and Corsini, Maddalena

Subjects
STABILITY constants, MOLECULES, LIGANDS (Biochemistry), IRON, SOIL remediation, CHELATING agents, CHELATION
Abstract

Because of their capacity to bind metals, metal chelators are primarily employed for therapeutic purposes, but they can also find applications as colorimetric reagents and cleaning solutions as well as in soil remediation, electroplating, waste treatment, and so on. For instance, iron-chelation therapy, which is used to treat iron-overload disorders, involves removing excess iron from the blood through the use of particular molecules, like deferoxamine, that have the ability to chelate the metal. The creation of bioinspired and biodegradable chelating agents is a crucial objective that draws inspiration from natural products. In this context, starting from bioavailable molecules such as maltol and pyrogallol, new molecules have been synthetized and characterized by potentiometry, infrared spectroscopy and cyclic voltammetry. Finally, the ability of these to bind iron has been investigated, and the stability constants of ferric complexes are measured using spectrophotometry. These compounds offer intriguing scaffolds for an innovative class of versatile, multipurpose chelating agents. [ABSTRACT FROM AUTHOR]

Published
2024
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21. A new bis-3-hydroxy-4-pyrone as a potential therapeutic iron chelating agent. Effect of connecting and side chains on the complex structures and metal ion selectivity

Author

Nurchi, Valeria M., Crisponi, Guido, Arca, Massimiliano, Crespo-Alonso, Miriam, Lachowicz, Joanna I., Mansoori, Delara, Toso, Leonardo, Pichiri, Giuseppina, Amelia Santos, M., Marques, Sergio M., Niclós-Gutiérrez, Juan, González-Pérez, Josefa M., Domínguez-Martín, Alicia, Choquesillo-Lazarte, Duane, Szewczuk, Zbigniew, Antonietta Zoroddu, M., and Peana, Massimiliano

Published
2014
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31. The meaning of aluminium exposure on human health and aluminium-related diseases

Author

Crisponi Guido, Fanni Daniela, Gerosa Clara, Nemolato Sonia, Nurchi Valeria M., Crespo-Alonso Miriam, Lachowicz Joanna I., and Faa Gavino

Subjects
aluminium, aluminium overload, aluminium-related disease, bone pathology, brain pathology, Biology (General), QH301-705.5
Abstract

The aim of this review is to attempt to answer extremely important questions related to aluminium-related diseases. Starting from an overview on the main sources of aluminium exposure in everyday life, the principal aspects of aluminium metabolism in humans have been taken into consideration in an attempt to enlighten the main metabolic pathways utilised by trivalent metal ions in different organs. The second part of this review is focused on the available evidence concerning the pathogenetic consequences of aluminium overload in human health, with particular attention to its putative role in bone and neurodegenerative human diseases.

Published
2013
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32. Gadolinium in Medical Imaging—Usefulness, Toxic Reactions and Possible Countermeasures : A Review

Author

Blomqvist, Lennart, Nordberg, Gunnar, Nurchi, Valeria M., Aaseth, Jan O., Blomqvist, Lennart, Nordberg, Gunnar, Nurchi, Valeria M., and Aaseth, Jan O.

Abstract

Gadolinium (Gd) is one of the rare-earth elements. The properties of its trivalent cation (Gd3+) make it suitable to serve as the central ion in chelates administered intravenously to patients as a contrast agent in magnetic resonance imaging. Such Gd-chelates have been used for more than thirty years. During the past decades, knowledge has increased about potential harmful effects of Gd-chelates in patients with severe renal dysfunction. In such patients, there is a risk for a potentially disabling and lethal disease, nephrogenic systemic fibrosis. Restricting the use of Gd-chelates in persons with severely impaired renal function has decreased the occurrence of this toxic effect in the last decade. There has also been an increasing awareness of Gd-retention in the body, even in patients without renal dysfunction. The cumulative number of doses given, and the chemical structure of the chelate given, are factors of importance for retention in tissues. This review describes the chemical properties of Gd and its medically used chelates, as well as its toxicity and potential side effects related to injection of Gd-chelates.

Published
2022
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34. Arsenic toxicity: Molecular targets and therapeutic agents

Author

Nurchi, Valeria M., Nurchi, Valeria M., Buha-Đorđević, Aleksandra, Crisponi, Guido, Alexander, Jan, Bjørklund, Geir, Aaseth, Jan, Nurchi, Valeria M., Nurchi, Valeria M., Buha-Đorđević, Aleksandra, Crisponi, Guido, Alexander, Jan, Bjørklund, Geir, and Aaseth, Jan

Abstract

High arsenic (As) levels in food and drinking water, or under some occupational conditions, can precipitate chronic toxicity and in some cases cancer. Millions of people are exposed to unacceptable amounts of As through drinking water and food. Highly exposed individuals may develop acute, subacute, or chronic signs of poisoning, characterized by skin lesions, cardiovascular symptoms, and in some cases, multi-organ failure. Inorganic arsenite(III) and organic arsenicals with the general formula R-As2+ are bound tightly to thiol groups, particularly to vicinal dithiols such as dihydrolipoic acid (DHLA), which together with some seleno-enzymes constitute vulnerable targets for the toxic action of As. In addition, R-As2+-compounds have even higher affinity to selenol groups, e.g., in thioredoxin reductase that also possesses a thiol group vicinal to the selenol. Inhibition of this and other ROS scavenging seleno-enzymes explain the oxidative stress associated with arsenic poisoning. The development of chelating agents, such as the dithiols BAL (dimercaptopropanol), DMPS (dimercapto-propanesulfonate) and DMSA (dimercaptosuccinic acid), took advantage of the fact that As had high affinity towards vicinal dithiols. Primary prevention by reducing exposure of the millions of people exposed to unacceptable As levels should be the prioritized strategy. However, in acute and subacute and even some cases with chronic As poisonings chelation treatment with therapeutic dithiols, in particular DMPS appears promising as regards alleviation of symptoms. In acute cases, initial treatment with BAL combined with DMPS should be considered.

Published
2020

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