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11. Burden of delirium on mortality and healthcare resource utilization in geriatric patients hospitalized for inflammatory bowel disease.

Author

Aldiabat, Mohammad, Aleyadeh, Wesam, Rana, Tabeer, Ta'ani, Omar Al, Alahmad, Majd, Ayoub, Malek, Jaber, Fouad, Obeidat, Adham, Numan, Laith, Manvar, Amar, and Alhuneafat, Laith

Abstract

Delirium is prevalent in elderly patients, linked to elevated mortality rates, heightened healthcare resource use, and caregiver burden. Inflammatory bowel disease (IBD) poses various delirium risk factors, yet the impact on geriatric IBD patient outcomes remains unexplored. Using 2016–2019 National Inpatient Sample data, we identified ≥65-year-old patients admitted for IBD (Crohn's, ulcerative colitis) management stratified by delirium presence as a secondary diagnosis. The study aimed to assess delirium's impact on geriatric IBD patient outcomes. Among 67,534 elderly IBD admissions, 0.7% (470) developed delirium. The delirium group had a 4.8-fold increase in in-hospital mortality risk (odds ratio 4.80, P < 0.001, 95% confidence interval [CI] 1.94–11.8). IBD patients with delirium experienced prolonged length of stay (adjusted mean difference 5.15 days, 95% CI 3.24–7.06, P < 0.001) and increased care costs (adjusted mean difference $48,328, 95% CI $26,485–$70,171, P < 0.001) compared to those without delirium. Elderly IBD patients with delirium face higher mortality risk, prolonged hospitalization, and increased healthcare costs. Clinicians should recognize delirium's detrimental effects in this vulnerable group and adhere to preventive protocols for improved care. [ABSTRACT FROM AUTHOR]

Published
2024
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12. The Hospital Frailty Risk Score as a Useful Inpatient Prognostic tool for Clostridioides difficile infections: A Nationwide Assessment

Author

Kilani, Yassine, primary, Alsakarneh, Saqr, additional, Aldiabat, Mohammad, additional, Puelo, Priscila Castro, additional, Mosquera, Daniel Alejandro Gonzalez, additional, Guatam, Misha, additional, Jaber, Fouad, additional, Sohail, Amir H., additional, Madi, Mahmoud Y., additional, Numan, Laith, additional, and Clarkston, Wendell K., additional

Published
2024
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14. Gastrointestinal Variant of Lemierre's Syndrome: A Systematic Review and Comprehensive Analysis of 36 Case Reports

Author

Jaber, Fouad, primary, Alsakarneh, Saqr, additional, Alsharaeh, Tala, additional, Salahat, Ahmed-Jordan, additional, Elfert, Khaled, additional, Beran, Azizullah, additional, Gangwani, Manesh Kumar, additional, Abboud, Yazan, additional, Al-sayyed, Leen, additional, Madi, Mahmoud Y., additional, Jaber, Mohammad, additional, Dahiya, Dushyant Singh, additional, Numan, Laith, additional, and Duong, Nikki, additional

Published
2023
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16. S458 A Comprehensive Analysis of Reported Adverse Events With Boston Scientific WallFlex Esophageal Stents: An FDA MAUDE Database Study

Author

Jaber, Fouad, primary, Alsakarneh, Saqr, additional, Beran, Azizullah, additional, Numan, Laith, additional, Jaber, Mohammad, additional, Abdelfattah, Thaer, additional, Musa, Rasheed, additional, Abdu, Manasik, additional, Abdalla, Abubaker, additional, Ahmed, Mohamed, additional, Igbinedion, Samuel, additional, and Bazarbashi, Ahmad Najdat, additional

Published
2023
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19. A Percutaneous Endoscopic Colostomy Tube to the Rescue

Author

Numan, Laith, primary, Brotherton, Tim, additional, Baliss, Michelle, additional, Ghosh, Soumojit, additional, Lamm, Vladimir, additional, Klos, Coen, additional, Sayuk, Gregory, additional, Presti, Michael, additional, and Elwing, Jill, additional

Published
2023
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20. S1329 A Systematic Time-Trend Analysis of the Global Incidence, Prevalence, and Mortality of Primary Liver Cancer From 1990 to 2019 Using the Global Burden of Diseases Study 2019

Author

Jaber, Fouad, primary, Alsakarneh, Saqr, additional, Mittal, Anika, additional, Alzghoul, Hamza, additional, Aldiabat, Mohammad, additional, Ahmed, Mohamed, additional, Beran, Azizullah, additional, Duong, Nikki, additional, Jaber, Mohammad, additional, Numan, Laith, additional, Abdallah, Mohamed, additional, Almeqdadi, Mohammad, additional, Mohan, Babu, additional, Abdel-Jalil, Ala, additional, and Ghoz, Hassan, additional

Published
2023
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21. S361 Increasing Incidence of Colorectal Cancer in Younger Adults: A Population-Based Time-Trend Analysis Using the Global Burden of Diseases Database, 1990-2019

Author

Alsakarneh, Saqr, primary, Jaber, Fouad, additional, Hassan, Noor, additional, Aldiabat, Mohammad, additional, Numan, Laith, additional, Abdelfattah, Thaer, additional, Beran, Azizullah, additional, Abdallah, Mohamed, additional, Clarkston, Wendell, additional, Bilal, Mohammad, additional, and Shaukat, Aasma, additional

Published
2023
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22. S1331 Gastrointestinal Variant of Lemierre's Syndrome: A Comprehensive Review and Analysis of 36 Case Reports

Author

Jaber, Fouad, primary, Alsakarneh, Saqr, additional, Alsharaeh, Tala, additional, Beran, Azizullah, additional, Campbell, John, additional, Jaber, Mohammad, additional, Salahat, Ahmed-Jordan, additional, Wilson, Natalie, additional, Abboud, Yazan, additional, Almeqdadi, Mohammad, additional, Numan, Laith, additional, Duong, Nikki, additional, Ghoz, Hassan, additional, Helzberg, John, additional, and Clarkston, Wendell, additional

Published
2023
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27. The National Burden of Colorectal Cancer in the United States from 1990 to 2019.

Author

Alsakarneh, Saqr, Jaber, Fouad, Beran, Azizullah, Aldiabat, Mohammad, Abboud, Yazan, Hassan, Noor, Abdallah, Mohamed, Abdelfattah, Thaer, Numan, Laith, Clarkston, Wendell, Bilal, Mohammad, and Shaukat, Aasma

Subjects
HEALTH policy, CANCER patient psychology, TIME, AGE distribution, DISEASE incidence, POPULATION geography, COLORECTAL cancer, SEX distribution, DISEASE prevalence, ECONOMIC aspects of diseases, HEALTH equity, HEALTH care rationing, DISEASE risk factors
Abstract

Simple Summary: Colorectal cancer (CRC) is a significant global health concern, ranking as the second leading cause of cancer-related deaths. Despite an overall decline in CRC rates in the United States, there is a concerning rise in early-onset cases (diagnosed before age 50). This study, utilizing comprehensive data from the Global Burden of Disease 2019, delves into the state-specific trends in CRC incidence, prevalence, and mortality over three decades (1990–2019). Notably, the research reveals varying patterns across geographic regions, gender, and age groups. Understanding these nuanced trends is crucial for targeted resource allocation and policy decisions to effectively combat CRC, a disease with an increasing impact on younger adults in the United States. CRC accounts for approximately a tenth of all cancer cases and deaths in the US. Due to large differences in demographics among the different states, we aim to determine trends in the CRC epidemiology and across different states, age groups, and genders. CRC rates, age-adjusted to the standard US population, were obtained from the GBD 2019 database. Time trends were estimated as annual percentage change (APC). A pairwise comparison was conducted between age- and gender-specific trends using the tests of parallelism and coincidence. Age-specific trends were also assessed in two age subgroups: younger adults aged 15–49 years and older adults aged 50–74 years. We also analyzed the prevalence, incidence, mortality, and DALYs in the US between 1990 and 2019. A total of 5.53 million patients were diagnosed with CRC in the US between 1990 and 2019. Overall, CRC incidence rates have significantly increased in younger adults (11.1 per 100,000 persons) and decreased in older adults (136.8 per 100,000 persons) (AAPC = 1.2 vs. −0.6; AAPC difference = 1.8, p < 0.001). Age-specific trends were neither identical (p < 0.001) nor parallel (p < 0.001), suggesting that CRC incidence rates are different and increasing at a greater rate in younger adults compared to older adults. However, for both men and women (49.4 and 35.2 per 100,000 persons), incidence rates have decreased over the past three decades at the same rate (AAPC = −0.5 vs. −0.5; AAPC difference = 0, p = 0.1). Geographically, the southern states had the highest mortality rates with Mississippi having the highest rate of 20.1 cases per 100,000 population in 2019. Massachusetts, New York, and the District of Colombia had the greatest decreases in mortality over the study period (−42.1%, −41.4%, and −40.9%). Decreased mortality was found in all states except Mississippi, where the mortality of CRC increased over the study period (+1.5%). This research provides crucial insights for policymakers to tailor resource allocation, emphasizing the dynamic nature of CRC burden across states and age groups, ultimately informing targeted strategies for prevention and intervention. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Comparison of viscous budesonide and fluticasone in the treatment of patients with eosinophilic esophagitis: a systematic review and meta-analysis.

Author

Numan, Laith, Kalot, Mohamad A., Brotherton, Tim, Tarakji, Ahmad, and Hamdeh, Shadi

Subjects
*EOSINOPHILIC esophagitis, *FLUTICASONE, *BUDESONIDE, *STEROID drugs, *RANDOMIZED controlled trials
Abstract

Background: Steroids are an important pharmacologic treatment in patients with eosinophilic esophagitis (EoE). Fluticasone and budesonide are the 2 main steroid medications used in EOE treatment, but current United States (US) guidelines do not recommend one agent over the other. In this study, we conducted a meta-analysis to compare important patient outcomes when both agents are used. Methods: A comprehensive search of MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus was performed from each database's inception to March 29th, 2023. Two independent reviewers systematically identified trials that compared the effect of budesonide vs. fluticasone in the management of EoE. A meta-analysis was performed using a fixed-effects model. The primary outcome was the histologic response (defined as an eosinophil count <15 per high-power field) which reflects the response to treatment. Results: Three studies met our inclusion criteria and were included in the analysis, with a total of 272 patients. All studies were carried out in the US and 1 was a randomized controlled trial. Our meta-analysis showed no statistically significant difference with the use of budesonide compared to fluticasone in achieving a histologic response (odds ratio 1.29, 95% confidence interval 0.77-2.14; P=0.34; I2=0%). Conclusion: Our systematic review and meta-analysis indicated no difference between budesonide and fluticasone in achieving a histologic response in patients with EoE. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Endoscopy for the diagnosis and treatment of gastrointestinal bleeding caused by malignancy

Author

Abu‐Sbeih, Hamzah, primary, Szafron, David, additional, Elkafrawy, Ahmed A., additional, Garcia‐Rodriguez, Victor, additional, Ma, Weijie, additional, Xu, Ann, additional, Khurana, Shruti, additional, Numan, Laith, additional, Chen, Ellie, additional, Goldstein, Ryan, additional, Tsen, Adrianne, additional, Peng, Yuanzun, additional, Blum, Mariela, additional, Kopetz, Edmund S, additional, Ikoma, Naruhiko, additional, Shatila, Malek, additional, Qiao, Wei, additional, Raju, Gottumukkala S., additional, Ross, William A, additional, Ge, Phillip S, additional, Coronel, Emmanuel, additional, and Wang, Yinghong, additional

Published
2022
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42. THIRTY DAY READMISSION FOR ERCP AFTER LIVER TRANSPLANTATION: A NATIONAL ANALYSIS

Author

Baliss, Michelle S., primary, Nguyen, Christopher, additional, Burton, Samuel, additional, Ghosh, Soumojit, additional, Numan, Laith, additional, Ahmed, Zarir, additional, Bilal, Mohammad, additional, Umar, Shifa, additional, Dang, Alexander, additional, Chrusciel, Timothy, additional, Taylor, Jason, additional, and Cheesman Rocca, Antonio R., additional

Published
2022
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