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19 results on '"Numaga, Takuro"'

2. Selective and Direct Inhibition of TRPC3 Channels Underlies Biological Activities of a Pyrazole Compound

Author

Kiyonaka, Shigeki, Kato, Kenta, Nishida, Motohiro, Mio, Kazuhiro, Numaga, Takuro, Sawaguchi, Yuichi, Yoshida, Takashi, Wakamori, Minoru, Mori, Emiko, Numata, Tomohiro, Ishii, Masakazu, Takemoto, Hiroki, Ojida, Akio, Watanabe, Kenta, Uemura, Aya, Kurose, Hitoshi, Morii, Takashi, Kobayashi, Tsutomu, Sato, Yoji, Sato, Chikara, Hamachi, Itaru, Mori, Yasuo, and Birnbaumer, Lutz

Published
2009
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11. Ca2+ influx and protein scaffolding via TRPC3 sustain PKC beta and ERK activation in B cells

Author

90422980, 60228715, 80212265, Numaga, Takuro, Nishida, Motohiro, Kiyonaka, Shigeki, Kato, Kenta, Katano, Masahiro, Mori, Emiko, Kurosaki, Tomohiro, Inoue, Ryuji, Hikida, Masaki, Putney Jr., James W., Mori, Yasuo, 90422980, 60228715, 80212265, Numaga, Takuro, Nishida, Motohiro, Kiyonaka, Shigeki, Kato, Kenta, Katano, Masahiro, Mori, Emiko, Kurosaki, Tomohiro, Inoue, Ryuji, Hikida, Masaki, Putney Jr., James W., and Mori, Yasuo

Published
2010

12. A Pathogenic C Terminus-truncated Polycystin-2 Mutant Enhances Receptor-activated Ca2+ Entry via Association with TRPC3 and TRPC7

Author

90422980, 80212265, Miyagi, Kyoko, Kiyonaka, Shigeki, Yamada, Kazunori, Miki, Takafumi, Mori, Emiko, Kato, Kenta, Numata, Tomohiro, Sawaguchi, Yuichi, Numaga, Takuro, Kimura, Toru, Kanai, Yoshikatsu, Kawano, Mitsuhiro, Wakamori, Minoru, Nomura, Hideki, Koni, Ichiro, Yamagishi, Masakazu, Mori, Yasuo, 90422980, 80212265, Miyagi, Kyoko, Kiyonaka, Shigeki, Yamada, Kazunori, Miki, Takafumi, Mori, Emiko, Kato, Kenta, Numata, Tomohiro, Sawaguchi, Yuichi, Numaga, Takuro, Kimura, Toru, Kanai, Yoshikatsu, Kawano, Mitsuhiro, Wakamori, Minoru, Nomura, Hideki, Koni, Ichiro, Yamagishi, Masakazu, and Mori, Yasuo

Published
2009

13. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

Author

90422980, 90222348, 90202259, 80212265, Kiyonaka, Shigeki, Kato, Kenta, Nishida, Motohiro, Mio, Kazuhiro, Numaga, Takuro, Sawaguchi, Yuichi, Yoshida, Takashi, Wakamori, Minoru, Mori, Emiko, Numata, Tomohiro, Ishii, Masakazu, Takemoto, Hiroki, Ojida, Akio, Watanabe, Kenta, Uemura, Aya, Kurose, Hitoshi, Morii, Takashi, Kobayashi, Tsutomu, Sato, Yoji, Sato, Chikara, Hamachi, Itaru, Mori, Yasuo, 90422980, 90222348, 90202259, 80212265, Kiyonaka, Shigeki, Kato, Kenta, Nishida, Motohiro, Mio, Kazuhiro, Numaga, Takuro, Sawaguchi, Yuichi, Yoshida, Takashi, Wakamori, Minoru, Mori, Emiko, Numata, Tomohiro, Ishii, Masakazu, Takemoto, Hiroki, Ojida, Akio, Watanabe, Kenta, Uemura, Aya, Kurose, Hitoshi, Morii, Takashi, Kobayashi, Tsutomu, Sato, Yoji, Sato, Chikara, Hamachi, Itaru, and Mori, Yasuo

Published
2009

14. A pyrazole compound selectively inhibits receptor activated TRPC3 channel

Author

Kato, Kenta, Kiyonaka, Shigeki, Nishida, Motohiro, Ishii, Masakazu, Mori, Emiko, Numaga, Takuro, Yoshida, Takashi, Miki, Takafumi, Kobayashi, Tsutomu, Morii, Takashi, Hamachi, Itaru, Wakamori, Minoru, Mori, Yasuo, Kato, Kenta, Kiyonaka, Shigeki, Nishida, Motohiro, Ishii, Masakazu, Mori, Emiko, Numaga, Takuro, Yoshida, Takashi, Miki, Takafumi, Kobayashi, Tsutomu, Morii, Takashi, Hamachi, Itaru, Wakamori, Minoru, and Mori, Yasuo

Published
2008

15. A pyrazole compound selectively inhibits receptor activated TRPC3 channel

Author

90422980, 90222348, 90202259, 80212265, Kato, Kenta, Kiyonaka, Shigeki, Nishida, Motohiro, Ishii, Masakazu, Mori, Emiko, Numaga, Takuro, Yoshida, Takashi, Miki, Takafumi, Kobayashi, Tsutomu, Morii, Takashi, Hamachi, Itaru, Wakamori, Minoru, Mori, Yasuo, 90422980, 90222348, 90202259, 80212265, Kato, Kenta, Kiyonaka, Shigeki, Nishida, Motohiro, Ishii, Masakazu, Mori, Emiko, Numaga, Takuro, Yoshida, Takashi, Miki, Takafumi, Kobayashi, Tsutomu, Morii, Takashi, Hamachi, Itaru, Wakamori, Minoru, and Mori, Yasuo

Published
2008

18. Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum.

Author

Baba, Yoshihiro, Hayashi, Kenji, Fujii, Yoko, Mizushima, Akiko, Watarai, Hiroshi, Wakamori, Minoru, Numaga, Takuro, Mori, Yasuo, Iino, Masamitsu, Hikida, Masaki, and Kurosaki, Tomohiro

Subjects
CELL membranes, CALCIUM channels, ENDOPLASMIC reticulum, ION channels, BIOLOGICAL membranes, ORGANELLES
Abstract

Depletion of intracellular calcium (Ca2+) stores induces store-operated Ca2+ (SOC) entry across the plasma membrane (PM). STIM1, a putative Ca2+ sensor in the endoplasmic reticulum (ER), has been recently shown to be necessary for SOC channel activation. Here we show that STIM1 dynamically moves in tubulovesicular shape on the ER and its subcompartment in resting living cells, whereas, upon Ca2+ store depletion, it is rapidly redistributed into discrete puncta that are located underneath, but not inserted into the PM. Normal constitutive movement of STIM1 is mediated through the coiled-coil and Ser/Thr-rich C-terminal domains in the cytoplasmic region of STIM1, whereas subsequent inducible puncta formation further requires the sterile α motif domain protruding into the ER lumen. Each of these three domains (coiled-coil, Ser/Thr-rich, and sterile α motif) was essential for activating SOC channels. Hence, our findings based on structure-function experiments suggest that constitutive dynamic movement of STIM1 in the ER and its subcompartment is obligatory for subsequent depletion-dependent redistribution of STIM1 into puncta underneath the PM and activation of SOC channels. [ABSTRACT FROM AUTHOR]

Published
2006
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19. Ca2+ influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells.

Author

Numaga, Takuro, Nishida, Motohiro, Kiyonaka, Shigeki, Kato, Kenta, Katano, Masahiro, Mori, Emiko, Kurosaki, Tomohiro, Inoue, Ryuji, Hikida, Masaki, Putney Jr., James W., and Mori, Yasuo

Subjects
*PHOSPHOLIPASE C, *INOSITOL, *DIGLYCERIDES, *ENDOPLASMIC reticulum, *PROTEIN kinases, *CELL membranes
Abstract

Ca2+ signaling mediated by phospholipase C that produces inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] and diacylglycerol (DAG) controls lymphocyte activation. In contrast to store-operated Ca2+ entry activated by Ins(1,4,5)P3-induced Ca2+ release from endoplasmic reticulum, the importance of DAG-activated Ca2+ entry remains elusive. Here, we describe the physiological role of DAG-activated Ca2+ entry channels in B-cell receptor (BCR) signaling. In avian DT40 B cells, deficiency of transient receptor potential TRPC3 at the plasma membrane (PM) impaired DAG-activated cation currents and, upon BCR stimulation, the sustained translocation to the PM of protein kinase Cβ (PKCβ) that activated extracellular signal-regulated kinase (ERK). Notably, TRPC3 showed direct association with PKCβ that maintained localization of PKCβ at the PM. Thus, TRPC3 functions as both a Ca2+-permeable channel and a protein scaffold at the PM for downstream PKCβ activation in B cells. [ABSTRACT FROM AUTHOR]

Published
2010
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