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Your search keyword '"Nuetzel, Margit"' showing total 11 results
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11 results on '"Nuetzel, Margit"'

1. Epigenetic alterations affecting hematopoietic regulatory networks as drivers of mixed myeloid/lymphoid leukemia

Author

Mulet-Lazaro, Roger, van Herk, Stanley, Nuetzel, Margit, Sijs-Szabo, Aniko, Díaz, Noelia, Kelly, Katherine, Erpelinck-Verschueren, Claudia, Schwarzfischer-Pfeilschifter, Lucia, Stanewsky, Hanna, Ackermann, Ute, Glatz, Dagmar, Raithel, Johanna, Fischer, Alexander, Pohl, Sandra, Rijneveld, Anita, Vaquerizas, Juan M., Thiede, Christian, Plass, Christoph, Wouters, Bas J., Delwel, Ruud, Rehli, Michael, and Gebhard, Claudia

Published
2024
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2. STAG2 mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia

Author

Fischer, Alexander, Hernández-Rodríguez, Benjamín, Mulet-Lazaro, Roger, Nuetzel, Margit, Hölzl, Fabian, van Herk, Stanley, Kavelaars, François G., Stanewsky, Hanna, Ackermann, Ute, Niang, Amadou H., Diaz, Noelia, Reuschel, Edith, Strieder, Nicholas, Hernández-López, Inmaculada, Valk, Peter J.M., Vaquerizas, Juan M., Rehli, Michael, Delwel, Ruud, and Gebhard, Claudia

Published
2024
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5. Changes in adenoviral chromatin organization precede early gene activation upon infection

Author

Schwartz, Uwe, primary, Komatsu, Tetsuro, additional, Huber, Claudia, additional, Lagadec, Floriane, additional, Baumgartl, Conradin, additional, Silberhorn, Elisabeth, additional, Nuetzel, Margit, additional, Rayne, Fabienne, additional, Basyuk, Eugenia, additional, Bertrand, Edouard, additional, Rehli, Michael, additional, Wodrich, Harald, additional, and Laengst, Gernot, additional

Published
2023
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6. Author Reply to Peer Reviews of Changes in adenoviral chromatin organization precede early gene activation

Author

Schwartz, Uwe, primary, Komatsu, Tetsuro, additional, Huber, Claudia, additional, Lagadec, Floriane, additional, Baumgartl, Conradin, additional, Silberhorn, Elisabeth, additional, Nuetzel, Margit, additional, Rayne, Fabienne, additional, Basyuk, Eugenia, additional, Bertrand, Edouard, additional, Rehli, Michael, additional, Wodrich, Harald, additional, and Längst, Gernot, additional

Published
2023
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7. Adenoviral chromatin organization primes for early gene activation

Author

Schwartz, Uwe, primary, Komatsu, Tetsuro, additional, Huber, Claudia, additional, Lagadec, Floriane, additional, Baumgartl, Conradin, additional, Silberhorn, Elisabeth, additional, Nuetzel, Margit, additional, Rayne, Fabienne, additional, Basyuk, Eugenia, additional, Bertrand, Edouard, additional, Rehli, Michael, additional, Wodrich, Harald, additional, and Laengst, Gernot, additional

Published
2020
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9. STAG2mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia

Author

Fischer, Alexander, Hernández-Rodríguez, Benjamín, Mulet-Lazaro, Roger, Nuetzel, Margit, Hölzl, Fabian, van Herk, Stanley, Kavelaars, François G., Stanewsky, Hanna, Ackermann, Ute, Niang, Amadou H., Diaz, Noelia, Reuschel, Edith, Strieder, Nicholas, Hernández-López, Inmaculada, Valk, Peter J.M., Vaquerizas, Juan M., Rehli, Michael, Delwel, Ruud, and Gebhard, Claudia

Abstract

Cohesin shapes the chromatin architecture, including enhancer-promoter interactions. Its components, especially STAG2, but not its paralog STAG1, are frequently mutated in myeloid malignancies. To elucidate the underlying mechanisms of leukemogenesis, we comprehensively characterized genetic, transcriptional, and chromatin conformational changes in acute myeloid leukemia (AML) patient samples. Specific loci displayed altered cohesin occupancy, gene expression, and local chromatin activation, which were not compensated by the remaining STAG1-cohesin. These changes could be linked to disrupted spatial chromatin looping in cohesin-mutated AMLs. Complementary depletion of STAG2 or STAG1 in primary human hematopoietic progenitors (HSPCs) revealed effects resembling STAG2-mutant AML-specific changes following STAG2 knockdown, not invoked by the depletion of STAG1. STAG2-deficient HSPCs displayed impaired differentiation capacity and maintained HSPC-like gene expression. This work establishes STAG2 as a key regulator of chromatin contacts, gene expression, and differentiation in the hematopoietic system and identifies candidate target genes that may be implicated in human leukemogenesis.

Published
2024
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10. Integrated Analysis of Global DNA Methylation and Transcription Reveals a Leukemia Subtype with Extreme Hypermethylation Associated with Silencing of Regulators of Differentiation

Author

Gebhard, Claudia, primary, Mulet-Lazaro, Roger, additional, Schwarzfischer, Lucia, additional, Glatz, Dagmar, additional, Nuetzel, Margit, additional, Heudobler, Daniel, additional, Pohl, Sandra, additional, Herr, Wolfgang, additional, Ehninger, Gerhard, additional, Erpelinck-Verschueren, Claudia, additional, van Herk, Stanley, additional, Wouters, B.J., additional, Thiede, Christian, additional, Delwel, Ruud, additional, and Rehli, Michael, additional

Published
2018
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11. Profiling of aberrant DNA methylation in acute myeloid leukemia reveals subclasses of CG-rich regions with epigenetic or genetic association

Author

Gebhard, Claudia, primary, Glatz, Dagmar, additional, Schwarzfischer, Lucia, additional, Wimmer, Julia, additional, Stasik, Sebastian, additional, Nuetzel, Margit, additional, Heudobler, Daniel, additional, Andreesen, Reinhard, additional, Ehninger, Gerhard, additional, Thiede, Christian, additional, and Rehli, Michael, additional

Published
2018
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