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644 results on '"Nucifora, Gaetano"'

7. Myocardial Substrate Characterization by CMR T1 Mapping in Patients With NICM and No LGE Undergoing Catheter Ablation of VT

Author

Muser, Daniele, Nucifora, Gaetano, Castro, Simon A., Enriquez, Andres, Chahal, C. Anwar A., Magnani, Silvia, Kumareswaran, Ramanan, Arkles, Jeffrey, Supple, Gregory, Schaller, Robert, Hyman, Matthew, Dixit, Sanjay, Lin, David, Zado, Erica S., Tschabrunn, Cory, Callans, David J., Nazarian, Saman, Frankel, David S., Marchlinski, Francis E., and Santangeli, Pasquale

Published
2021
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9. Clinical Applications of Cardiac Magnetic Resonance Parametric Mapping.

Author

Muser, Daniele, Chahal, Anwar A., Selvanayagam, Joseph B., and Nucifora, Gaetano

Subjects
CARDIAC magnetic resonance imaging, MAGNETIC resonance imaging, MYOCARDIAL injury, CONTRAST media, MAGNETIC resonance
Abstract

Cardiovascular magnetic resonance (CMR) imaging is widely regarded as the gold-standard technique for myocardial tissue characterization, allowing for the detection of structural abnormalities such as myocardial fatty replacement, myocardial edema, myocardial necrosis, and/or fibrosis. Historically, the identification of abnormal myocardial regions relied on variations in tissue signal intensity, often necessitating the use of exogenous contrast agents. However, over the past two decades, innovative parametric mapping techniques have emerged, enabling the direct quantitative assessment of tissue magnetic resonance (MR) properties on a voxel-by-voxel basis. These mapping techniques offer significant advantages by providing comprehensive and precise information that can be translated into color-coded maps, facilitating the identification of subtle or diffuse myocardial abnormalities. As unlikely conventional methods, these techniques do not require a substantial amount of structurally altered tissue to be visually identifiable as an area of abnormal signal intensity, eliminating the reliance on contrast agents. Moreover, these parametric mapping techniques, such as T1, T2, and T2* mapping, have transitioned from being primarily research tools to becoming valuable assets in the clinical diagnosis and risk stratification of various cardiac disorders. In this review, we aim to elucidate the underlying physical principles of CMR parametric mapping, explore its current clinical applications, address potential pitfalls, and outline future directions for research and development in this field. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Risk Stratification of Patients With Apparently Idiopathic Premature Ventricular Contractions: A Multicenter International CMR Registry

Author

Muser, Daniele, Santangeli, Pasquale, Castro, Simon A., Casado Arroyo, Ruben, Maeda, Shingo, Benhayon, Daniel A., Liuba, Ioan, Liang, Jackson J., Sadek, Mouhannad M., Chahal, Anwar, Magnani, Silvia, Pieroni, Maurizio, Santarossa, Elena, Desjardins, Benoit, Dixit, Sanjay, Garcia, Fermin C., Callans, David J., Frankel, David S., Alavi, Abass, Marchlinski, Francis E., Selvanayagam, Joseph B., and Nucifora, Gaetano

Published
2020
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18. 7 Myocardial t1 dispersion in fabry disease: comprehensive evaluation of a novel measurement of cardiovascular disease severity

Author

Orsborne, Chris, primary, Clark, David, additional, Nucifora, Gaetano, additional, Woolfson, Peter, additional, Abidin, Nik, additional, Reid, Anna, additional, Pleva, Luke, additional, Bradley, Joshua, additional, Schmitt, Matthias, additional, Miller, Christopher, additional, Naish, Josephine, additional, and Jovanovic, Ana, additional

Published
2023
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23. Prognostic role of serial quantitative evaluation of 18F-fluorodeoxyglucose uptake by PET/CT in patients with cardiac sarcoidosis presenting with ventricular tachycardia

Author

Muser, Daniele, Santangeli, Pasquale, Castro, Simon A., Liang, Jackson J., Enriquez, Andres, Werner, Thomas J., Nucifora, Gaetano, Magnani, Silvia, Hayashi, Tatsuya, Zado, Erica S., Garcia, Fermin C., Callans, David J., Dixit, Sanjay, Desjardins, Benoit, Marchlinski, Francis E., and Alavi, Abass

Published
2018
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25. Late gadolinium enhancement and the risk of ventricular arrhythmias and sudden death in NYHA class I patients with non‐ischaemic cardiomyopathy

Author

Di Marco, Andrea, primary, Brown, Pamela, additional, Mateus, Gemma, additional, Faga, Valentina, additional, Nucifora, Gaetano, additional, Claver, Eduard, additional, Viedma, Jisela, additional, Galvan, Francisco, additional, Bradley, Joshua, additional, Dallaglio, Paolo D., additional, de Frutos, Fernando, additional, Miller, Christopher A., additional, Comín‐Colet, Josep, additional, Anguera, Ignasi, additional, and Schmitt, Matthias, additional

Published
2023
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32. Prognostic impact of late gadolinium enhancement at the right ventricular insertion points in non-ischaemic dilated cardiomyopathy

Author

Claver, Eduard, primary, Di Marco, Andrea, additional, Brown, Pamela Frances, additional, Bradley, Joshua, additional, Nucifora, Gaetano, additional, Ruiz-Majoral, Alejandro, additional, Dallaglio, Paolo Domenico, additional, Rodriguez, Marcos, additional, Comin-Colet, Josep, additional, Anguera, Ignasi, additional, Miller, Christopher A., additional, and Schmitt, Matthias, additional

Published
2022
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33. D A novel internally validated risk prediction model for adverse cardiac outcome in fabry disease

Author

Orsborne, Christopher, primary, Bradley, Joshua, additional, Bonnett, Laura J, additional, Pleva, Luke A, additional, Naish, Josephine H, additional, Clark, David G, additional, Abidin, Nik, additional, Woolfson, Peter, additional, Nucifora, Gaetano, additional, Schmitt, Matthias, additional, Jovanovic, Ana, additional, Miller, Christopher A, additional, and Reid, Anna B, additional

Published
2022
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34. 149 A novel internally validated risk prediction model for adverse cardiac outcome in fabry disease

Author

Orsborne, Christopher, primary, Bradley, Joshua, additional, Bonnett, Laura J, additional, Pleva, Luke A, additional, Naish, Josephine H, additional, Clark, David G, additional, Abidin, Nik, additional, Woolfson, Peter, additional, Nucifora, Gaetano, additional, Schmitt, Matthias, additional, Jovanovic, Ana, additional, Miller, Christopher A, additional, and Reid, Anna, additional

Published
2022
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37. Extracellular volume fraction improves risk-stratification for ventricular arrhythmias and sudden death in non-ischaemic cardiomyopathy.

Author

Marco, Andrea Di, Brown, Pamela F, Bradley, Joshua, Nucifora, Gaetano, Anguera, Ignasi, Miller, Christopher A, and Schmitt, Matthias

Subjects
SUDDEN death, VENTRICULAR ejection fraction, PREDICTIVE tests, MYOCARDIAL ischemia, MAGNETIC resonance imaging, IMPLANTABLE cardioverter-defibrillators, VENTRICULAR tachycardia, VENTRICULAR arrhythmia, CARDIAC arrest, EXTRACELLULAR space, SECONDARY analysis, LONGITUDINAL method, DISEASE risk factors
Abstract

Aims To evaluate whether cardiac magnetic resonance (CMR)-based parametric mapping and strain analysis can improve the risk-stratification for ventricular arrhythmias (VA) and sudden death (SD) in non-ischaemic cardiomyopathy (NICM). Methods and results Secondary analysis of a prospective single-centre-registry (NCT02326324), including 703 consecutive NICM patients, 618 with extracellular volume (ECV) available. The combined primary endpoint included appropriate implantable cardioverter defibrillator therapies, sustained ventricular tachycardia, resuscitated cardiac arrest and SD. During a median follow-up of 21 months, 14 patients (2%) experienced the primary endpoint. Native T1 was not associated with the primary endpoint. Left ventricular global longitudinal strain lost its significant association after adjustment for left ventricular ejection fraction (LVEF). Among patients with ECV available, 11 (2%) reached the primary endpoint. Mean ECV was significantly associated with the primary endpoint and the best cut-off was 30%. ECV ≥ 30% was the strongest independent predictor of the primary endpoint (hazard ratio 14.1, P = 0.01) after adjustment for late gadolinium enhancement (LGE) and LVEF. ECV ≥ 30% discriminated the arrhythmic risk among LGE+ cases and among those with LVEF ≤ 35%. A simple clinical risk-stratification model, based on LGE, LVEF ≤ 35% and ECV ≥ 30%, achieved an excellent predictive ability (Harrell's C 0.82) and reclassified the risk of 32% of the study population as compared to LVEF ≤ 35% alone. Conclusions Comprehensive CMR evaluation in NICM showed that ECV was the only parameter with an independent and strong predictive value for VA/SD, on top of LGE and LVEF. A risk-stratification model based on LGE, LVEF ≤ 35% and ECV ≥ 30% achieved an excellent predictive ability for VA/SD. Clinical Trial Registration UHSM CMR study (NCT02326324) https://clinicaltrials.gov/ct2/show/NCT02326324. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Prognostic impact of late gadolinium enhancement at the right ventricular insertion points in non-ischaemic dilated cardiomyopathy.

Author

Claver, Eduard, Marco, Andrea Di, Brown, Pamela Frances, Bradley, Joshua, Nucifora, Gaetano, Ruiz-Majoral, Alejandro, Dallaglio, Paolo Domenico, Rodriguez, Marcos, Comin-Colet, Josep, Anguera, Ignasi, Miller, Christopher A, and Schmitt, Matthias

Subjects
EXPERIMENTAL design, RESEARCH, MAGNETIC resonance angiography, RIGHT heart ventricle, RETROSPECTIVE studies, CHEMICAL elements, COMPARATIVE studies, DILATED cardiomyopathy, DESCRIPTIVE statistics, RESEARCH bias, LONGITUDINAL method
Abstract

Aims To evaluate the baseline characteristics and the prognostic implications associated with late gadolinium enhancement limited to the right ventricular insertion points (IP-LGE) or present at both the right ventricular insertion points and the left ventricle (IP&LV-LGE) in non-ischaemic dilated cardiomyopathy (DCM). Methods and results This is a retrospective observational multicentre cohort study including 1165 consecutive patients with DCM evaluated by cardiac magnetic resonance. The primary endpoint included appropriate defibrillator therapies, sustained ventricular tachycardia, resuscitated cardiac arrest, or sudden death. The secondary outcome encompassed heart failure hospitalizations, heart transplant, left ventricular assist device implantation, and end-stage heart failure death. IP-LGE was found in 72 patients (6%), who had clinical characteristics closer to LGE− than to LGE+ patients. During follow-up (median 36 months), none of the IP-LGE patients experienced the primary endpoint. The cumulative incidence of the primary endpoint was similar between IP-LGE and LGE− patients (P = 1), while IP-LGE had significantly lower cumulative incidence when compared with LGE+ patients (P < 0.001). When compared with IP-LGE patients, the cumulative incidence of the secondary endpoint was similar in LGE− cases (P = 0.86) but tended to be higher in LGE+ patients (P = 0.06). Both clinical characteristics and outcomes were similar between IP&LV-LGE patients and the rest of LGE+ cases. Conclusions In a large cohort of DCM patients, IP-LGE was associated with similar outcome when compared with LGE− patients and with significant lower risk of ventricular arrhythmias and sudden death when compared with LGE+ cases. Patients with IP&LV-LGE had clinical characteristics and outcomes similar to the rest of LGE+ cases. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Acute and Chronic Cardiopulmonary Effects of High Dose Interleukin-2 Therapy: An Observational Magnetic Resonance Imaging Study

Author

Lagan, Jakub, primary, Naish, Josephine H., additional, Fortune, Christien, additional, Campbell, Christopher, additional, Chow, Shien, additional, Pillai, Manon, additional, Bradley, Joshua, additional, Francis, Lenin, additional, Clark, David, additional, Macnab, Anita, additional, Nucifora, Gaetano, additional, Dobson, Rebecca, additional, Schelbert, Erik B., additional, Schmitt, Matthias, additional, Hawkins, Robert, additional, and Miller, Christopher A., additional

Published
2022
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41. Global longitudinal strain by CMR improves prognostic stratification in acute myocarditis presenting with normal LVEF

Author

Porcari, Aldostefano, primary, Merlo, Marco, additional, Baggio, Chiara, additional, Gagno, Giulia, additional, Cittar, Marco, additional, Barbati, Giulia, additional, Paldino, Alessia, additional, Castrichini, Matteo, additional, Vitrella, Giancarlo, additional, Pagnan, Lorenzo, additional, Cannatà, Antonio, additional, Andreis, Alessandro, additional, Cecere, Annagrazia, additional, Cipriani, Alberto, additional, Raafs, Anne, additional, Bromage, Daniel I., additional, Rosmini, Stefania, additional, Scott, Paul, additional, Sado, Daniel, additional, Di Bella, Gianluca, additional, Nucifora, Gaetano, additional, Marra, Martina Perazzolo, additional, Heymans, Stephane, additional, Imazio, Massimo, additional, and Sinagra, Gianfranco, additional

Published
2022
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43. CE-544-03 INCIDENCE AND PREDICTORS OF ACQUIRED LV DYSFUNCTION IN PATIENTS WITH ASYMPTOMATIC FREQUENT PREMATURE VENTRICULAR COMPLEXES: A LONGITUDINAL CMR STUDY

Author

Magnani, Silvia, primary, Muser, Daniele, additional, Nucifora, Gaetano, additional, Enriquez, Andres, additional, Castro, Simon A., additional, Liuba, Ioan, additional, Dechyapirom Bode, Weeranun, additional, Arkles, Jeffrey, additional, Zado, Erica S., additional, Schaller, Robert D., additional, Deo, Rajat, additional, Garcia, Fermin C., additional, Frankel, David S., additional, Callans, David J., additional, Ricardo Arceluz, Martín, additional, Lin, David, additional, Tschabrunn, Cory M., additional, Marchlinski, Francis E., additional, and Santangeli, Pasquale, additional

Published
2022
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44. PO-714-08 DIFFUSE INTERSTITIAL FIBROSIS DETECTED BY CMR-T1 MAPPING TO IDENTIFY IRREVERSIBILITY OF LV CARDIOMYOPATHY IN PATIENTS WITH FREQUENT PREMATURE VENTRICULAR COMPLEXES

Author

Muser, Daniele, primary, Magnani, Silvia, additional, Nucifora, Gaetano, additional, Enriquez, Andres, additional, Liuba, Ioan, additional, Chahal, Anwar A., additional, Arceluz, Martín Ricardo, additional, Castro, Simon A., additional, Bode, Weeranun Dechyapirom, additional, Arkles, Jeffrey, additional, Lin, David, additional, Tschabrunn, Cory M., additional, Zado, Erica S., additional, Schaller, Robert D., additional, Deo, Rajat, additional, Garcia, Fermin C., additional, Frankel, David S., additional, Callans, David J., additional, Marchlinski, Francis E., additional, and Santangeli, Pasquale, additional

Published
2022
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45. PO-715-06 RINGLIKE LEFT VENTRICULAR CARDIOMYOPATHY: A DISTINCT FAMILIAL FORM OF ARRHYTHMOGENIC CARDIOMYOPATHY

Author

Muser, Daniele, primary, Nucifora, Gaetano, additional, Casella, Michela, additional, Tritto, Massimo, additional, Magnani, Silvia, additional, Compagnucci, Paolo, additional, Zagari, Domenico, additional, Enriquez, Andres, additional, Liuba, Ioan, additional, Chahal, Anwar A., additional, Arceluz, Martín Ricardo, additional, Castro, Simon A., additional, Bode, Weeranun Dechyapirom, additional, Arkles, Jeffrey, additional, Lin, David, additional, Tschabrunn, Cory M., additional, Zado, Erica S., additional, Schaller, Robert D., additional, Deo, Rajat, additional, Garcia, Fermin C., additional, Frankel, David S., additional, Russo, Antonio Dello, additional, Callans, David J., additional, Pieroni, Maurizio, additional, Marchlinski, Francis E., additional, and Santangeli, Pasquale, additional

Published
2022
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46. The Diagnostic and Prognostic Utility of Contemporary Cardiac Magnetic Resonance in Suspected Acute Myocarditis

Author

Lagan, Jakub, primary, Fortune, Christien, additional, Hutchings, David, additional, Bradley, Joshua, additional, Naish, Josephine H., additional, Timoney, Richard, additional, Prescott, Daniel, additional, Bain, Hamish D. C., additional, Bangi, Tasneem, additional, McIntosh, Jerome, additional, Egdell, Robin, additional, Irwin, R. Bruce, additional, Clark, David, additional, Schelbert, Erik B., additional, Nucifora, Gaetano, additional, Schmitt, Matthias, additional, and Miller, Christopher A., additional

Published
2022
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47. 73 Prevalence and prognostic significance of ischaemic late gadolinium enhancement pattern in non-ischaemic dilated cardiomyopathy

Author

De Angelis, Giulia, primary, De Luca, Antonio, additional, Merlo, Marco, additional, Nucifora, Gaetano, additional, Rossi, Maddalena, additional, Stolfo, Davide, additional, De Bellis, Annamaria, additional, Barbati, Giulia, additional, Santangeli, Pasquale, additional, Mase, Marco, additional, Pagnan, Lorenzo, additional, Muser, Daniele, additional, and Sinagra, Gianfranco, additional

Published
2021
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48. 100 Global longitudinal strain by CMR improves prognostic stratification in acute myocarditis presenting with normal LVEF

Author

Porcari, Aldostefano, primary, Merlo, Marco, additional, Baggio, Chiara, additional, Gagno, Giulia, additional, Cittar, Marco, additional, Barbati, Giulia, additional, Paldino, Alessia, additional, Castrichini, Matteo, additional, Vitrella, Giancarlo, additional, Pagnan, Lorenzo, additional, Cannata, Antonio, additional, Andreis, Alessandro, additional, Cecere, Annagrazia, additional, Cipriani, Alberto, additional, Raafs, Anne, additional, Bromage, Daniel I, additional, Rosmini, Stefania, additional, Scott, Paul, additional, Sado, Daniel, additional, Di Bella, Gianluca, additional, Nucifora, Gaetano, additional, Marra, Martina Perazzolo, additional, Heymans, Stephane, additional, Imazio, Massimo, additional, and Sinagra, Gianfranco, additional

Published
2021
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